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7. Poster Discussions

Author

López, J., Jiménez, M., Peláez, J., Arce, M. A., Asensio, M. J., Arnalich, F., Hernanz, A., Zweigner, J., Gramm, H. -J., Lamping, N., Kopf, A., Asmus, A., Schumann, R. R., Zimmermann, J., Meinhold, H., Beier, W., Wegscheider, K., Murphy, M., Catania, A., Cutuli, M., Garofalo, L., Valenza, F., Lipton, J. M., Berger, D., Boelke, E., Hiki, N., Lissner, R., Arnold, A., Hausmann, F., Seidelmann, M., Beger, H. G., Berger, D., Braunmueller, H. D., Bōlke, E., Schmidt, U., Ott, S., Seidelmann, H., Bohuon, C., Raymond, J., Assicot, M., Moulin, F., Bergeret, M., Lebon, P., Gendrei, D., Lantéri-Minet, M., Scoazec, J. Y., Dosquet, C., Beyne, P., Voitot, H., Mencia-Huerta, J. M., Lettéron, P., Lebrec, D., Lehmann, C. H., Egerer, K., Georgiew, A., Weber, M., Kox, W. J., Brunkhorst, F. M., Forycki, Z. F., Beier, W., Wagner, J., Orfanos, S. E., Armaganidis, A., Bardouniotou, H., Mavrommati, I., Catravas, J. D., Economidou, J., and Roussos, Ch.

Published
1996
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8. Réflexions sur le Dosage de la Catéchol O Méthyl Transférase et de la Monoamine Oxydase dans les Neuroblastomes

Author

Bohuon, C., La Brosse, E. H., Assicot, M., Amar-Costesec, A., Allfrey, V. G., editor, Allgöwer, M., editor, Bauer, K. H., editor, Berenblum, I., editor, Bergel, F., editor, Bernard, J., editor, Bernhard, W., editor, Blokhin, N. N., editor, Bock, H. E., editor, Bucalossi, P., editor, Chaklin, A. V., editor, Chorazy, M., editor, Cunningham, G. J., editor, Dameshek, W., editor, Dargent, M., editor, Delia Porta, G., editor, Denoix, P., editor, Dulbecco, R., editor, Eagle, H., editor, Eker, R., editor, Grabar, P., editor, Hamperl, H., editor, Harris, R. J. C., editor, Hecker, E., editor, Herbeuval, R., editor, Hueper, W. C., editor, Isliker, H., editor, Karnojsky, D. A., editor, Kieler, J., editor, Klein, G., editor, Koss, L. G., editor, Martz, G., editor, Mathé, G., editor, Mühlbock, O., editor, Pack, G. T., editor, Potter, V. R., editor, Sachs, L., editor, Saxén, E. A., editor, Szybalski, W., editor, Tagnon, H., editor, Taylor, R. M., editor, Tissières, A., editor, Uehlinger, E., editor, Yoshida, T., editor, Zilber, L. A., editor, Rentchnick, P., editor, and Bohuon, C., editor

Published
1966
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14. Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations

Author

Michel P. Glauser, Corradin Sb, Assicot M, Gallati H, Bohuon C, de Werra I, J. D. Baumgartner, René Chioléro, Jaccard C, D. Heumann, and Bertrand Yersin

Subjects
Adult, Calcitonin, Male, inorganic chemicals, Calcitonin Gene-Related Peptide, Shock, Cardiogenic, Critical Care and Intensive Care Medicine, Receptors, Tumor Necrosis Factor, Procalcitonin, Microbiology, Cohort Studies, Diagnosis, Differential, Predictive Value of Tests, Intensive care, Pneumonia, Bacterial, medicine, Humans, Protein Precursors, Nitrites, Aged, Aged, 80 and over, Nitrates, Interleukin-6, Tumor Necrosis Factor-alpha, Septic shock, business.industry, Cardiogenic shock, Bacterial pneumonia, Interleukin, Middle Aged, medicine.disease, Shock, Septic, Shock (circulatory), Immunology, Cytokines, Female, Tumor necrosis factor alpha, medicine.symptom, business, Biomarkers
Abstract

To determine and compare the respective concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, soluble TNF receptors, nitrite/nitrate (NO2-/NO3-), and procalcitonin in the plasma of patients with septic shock, cardiogenic shock, and bacterial pneumonia without shock; and to assess the predictive value of these mediators in defining patients with septic shock.Cohort study, comparing normal volunteers (controls) and patients with septic shock, cardiogenic shock, and bacterial pneumonia.A collaborative study among an intensive care unit, an emergency room, and three research laboratories.Mediators were measured at various times in 15 patients with septic shock (during the shock phase and during the recovery phase), in seven patients with cardiogenic shock during the shock phase, and in seven patients with severe bacterial pneumonia on day 1 of admission.Blood samples were collected at various times during the course of the disease.TNF-alpha values were highest in the acute phase of septic shock (53 to 131 pg/mL during septic shock), while patients with bacterial pneumonia had intermediate concentrations (32 pg/mL). TNF-alpha concentrations were normal in patients with cardiogenic shock. IL-6 concentrations were highest in patients with acute septic shock (85 to 385 pg/mL). However, in contrast to TNF-alpha concentrations, IL-6 concentrations were normal in patients with bacterial pneumonia and increased in patients with cardiogenic shock (78 pg/mL). Soluble TNF receptors were increased in all three groups vs. controls, with the highest increase in patients with septic shock. NO2-/NO3- concentrations were highest (72 to 140 mM) in patients with septic shock, and were40 mM in the other groups of patients. Procalcitonin concentrations were only markedly increased in patients with septic shock (72 to 135 ng/mL, compared with approximately 1 ng/mL in the three other groups). The best predictive value for septic shock was found to be the measurements of NO2-/NO3- and procalcitonin concentrations.These observations showed that increase of proinflammatory cytokines was a consequence of inflammation, not of shock. In this study comparing various shock and infectious states, measurements of NO2-/NO3- concentration and procalcitonin concentration represented the most suitable tests for defining patients with septic shock.

Published
1997
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15. Conclusion

Author

Bohuon, C., Allfrey, V. G., editor, Allgöwer, M., editor, Bauer, K. H., editor, Berenblum, I., editor, Bergel, F., editor, Bernard, J., editor, Bernhard, W., editor, Blokhin, N. N., editor, Bock, H. E., editor, Bucalossi, P., editor, Chaklin, A. V., editor, Chorazy, M., editor, Cunningham, G. J., editor, Dameshek, W., editor, Dargent, M., editor, Delia Porta, G., editor, Denoix, P., editor, Dulbecco, R., editor, Eagle, H., editor, Eker, R., editor, Grabar, P., editor, Hamperl, H., editor, Harris, R. J. C., editor, Hecker, E., editor, Herbeuval, R., editor, Hueper, W. C., editor, Isliker, H., editor, Karnojsky, D. A., editor, Kieler, J., editor, Klein, G., editor, Koss, L. G., editor, Martz, G., editor, Mathé, G., editor, Mühlbock, O., editor, Pack, G. T., editor, Potter, V. R., editor, Sachs, L., editor, Saxén, E. A., editor, Szybalski, W., editor, Tagnon, H., editor, Taylor, R. M., editor, Tissières, A., editor, Uehlinger, E., editor, Yoshida, T., editor, Zilber, L. A., editor, Rentchnick, P., editor, and Bohuon, C., editor

Published
1966
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24. [Stomach adenocarcinomas: comparison between CA 19-9 and carcinoembryonic antigen for the diagnosis of recurrences after surgical treatment]

Author

Ychou M, Tuszinski T, Jean-Pierre PIGNON, Jm, Bidart, Bellet D, Bohuon C, and Rougier P

Subjects
Adult, Male, Adenocarcinoma, Middle Aged, Carcinoembryonic Antigen, Stomach Neoplasms, Humans, Antigens, Tumor-Associated, Carbohydrate, Female, Prospective Studies, Neoplasm Metastasis, Neoplasm Recurrence, Local, Aged, Follow-Up Studies
Abstract

The aim of this study was to compare carcinoembryonic antigen (CEA) and CA19-9 for the detection of local recurrences and distant metastases after complete resection of gastric carcinoma. At least one postoperative measurement of CEA and CA19-9 was performed in 54 patients. Among these, 32 had recurrence (59%) with a median follow-up of 618 days. Significantly higher sensitivity was observed for CA19-9 in comparison with CEA (68.8% vs 38.2% respectively), but specificity was slightly lower (81.8% vs 95.6% respectively). Increased CEA plasma level never preceded the diagnosis of recurrence while increasing CA19-9 preceded diagnosis in 13 patients (40.6%) from 1 to 22 months (median = 4.5 months). Increasing the normal range of CA19-9 to 80 UI/mL (2.5 x N) raises the specificity to 100% with acceptable sensitivity (53.1%). This study shows that CA19-9, compare with CEA, allows diagnosis of recurrence more often and earlier in the follow-up of resected gastric cancer.

Published
1992

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