40 results on '"Bohlender JE"'
Search Results
2. Prävalidierung der ersten deutschen Version des Vocal Fatigue Index (VFIdt.)
- Author
-
Stappenbeck, LE, Bohlender, JE, and Brockmann-Bauser, M
- Subjects
ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Hintergrund Pathologische Stimmermüdung (vocal fatigue) ist ein im klinischen Alltag bei Patienten mit Stimmstörungen (Dysphonien) häufig beschriebenes Phänomen. Dabei weisen die Betroffenen oft eine verminderte stimmliche Belastbarkeit auf, welche lange als bloßes Symptom[zum vollständigen Text gelangen Sie über die oben angegebene URL], 34. Wissenschaftliche Jahrestagung der Deutschen Gesellschaft für Phoniatrie und Pädaudiologie (DGPP), Dreiländertagung D-A-CH
- Published
- 2017
- Full Text
- View/download PDF
3. Unmittelbare Effekte des Lip Trills auf akustische und subjektive stimmdiagnostische Parameter
- Author
-
Balandat, B, Brockmann-Bauser, M, and Bohlender, JE
- Subjects
ddc: 610 ,610 Medical sciences ,Medicine - Abstract
[zum vollständigen Text gelangen Sie über die oben angegebene URL], 34. Wissenschaftliche Jahrestagung der Deutschen Gesellschaft für Phoniatrie und Pädaudiologie (DGPP), Dreiländertagung D-A-CH
- Published
- 2017
- Full Text
- View/download PDF
4. Die Reliabilität der ersten deutschen Version des Dysphagia Handicap Index (DHI)
- Author
-
Brockmann-Bauser, M, Jud, S, Vith, U, and Bohlender, JE
- Subjects
ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Einleitung Die schluckbezogene Lebensqualität von Patienten mit Schluckstörungen (Dysphagie) ist subjektiv unterschiedlich stark eingeschränkt. Somit ist die standardisierte Erhebung von Beschwerden aus Patientensicht ein wesentliches Kriterium zur Planung und Evaluation einer Behandlung.[zum vollständigen Text gelangen Sie über die oben angegebene URL], 33. Wissenschaftliche Jahrestagung der Deutschen Gesellschaft für Phoniatrie und Pädaudiologie (DGPP)
- Published
- 2016
- Full Text
- View/download PDF
5. Die Balanced Scorecard (BSC) als Instrument zur Umsetzung von eLearning in einer phoniatrisch-pädaudologischen Klinik
- Author
-
Pinsker, K, Bohlender, JE, Fix, T, Straub, S, and Gross, M
- Subjects
ddc: 610 - Abstract
Die eLearning-Wissensvermittlung im Fach Phoniatrie und Pädaudiologie an der Charité-Universitätsmedizin Berlin steht im Kontext mit der neuen Studienordnung und dem neuen Curriculum für den Regelstudiengang Medizin und zielt ab auf eine solide Grundlage für weitere Modernisierung und Qualitätsoptimierung der Lehre. Der neuen Lehr- und Lernkultur folgend, soll der Regelstudiengang Medizin ein möglichst praxisnahes und lernorientiertes Ausbildungsprofil erhalten. Die Steigerung der Effizienz und Qualität der Lehre soll durch die Nutzung elektronischer Lehr- und Lerntechnologien erhöht werden. Zur erfolgreichen Realisierung ist eLearning als strategisch-integrativer Prozess im Fakultätskonzept der Charité verankert. Die Balanced Scorecard (BSC) wurde als geeignetes Instrument zur Umsetzung der eLearning-Strategie identifiziert, um Strukturen zu schaffen, eLearning langfristig in der universitären Lehre zu etablieren, ferner die Nachhaltigkeit zu optimieren und eLearning in dem Gesamtkonzept der medizinischen Ausbildung zu verankern. Die Balanced Scorecard stellt eine Fortführung und Konkretisierung finanzwirtschaftlicher Kennzahlensysteme dar. Sie verbindet strategisches Management mit traditionellen Kennzahlen indem sie gleichzeitig und balanciert die vier Dimensionen Mitarbeiter, Prozesse/Produkte, Kunden/Markt und Finanzen einbezieht und auf Ursachen-Wirkungsketten basiert. Erste Ergebnisse zeigen, dass die BSC in der Lage ist, die Umsetzung der Unternehmenskonzepte auch für nachgeordnete Strukturen transparenter darzustellen und die Steuerung der Prozesse anhand von Messgrößen zu vereinfachen. Es wird davon ausgegangen, dass die Umsetzung der BSC an der Fakultät einen maßgeblichen Beitrag zum Transfer des eLearning in die Lehre und zur Nachhaltigkeit leistet.
- Published
- 2007
6. Gemeinsame Grundlagen von Tast- und Hörsinn - erste klinische Ergebnisse
- Author
-
Bohlender, JE, Frenzel, H, Rosenfeld, J, Lewin, G, and Gross, M
- Subjects
ddc: 610 - Abstract
Die durch Myosinproteine gesteuerten sensorischen Haarzellen des Innenohres entsprechen nach neuesten Erkenntnissen der Myosinaktivität in den mechanosensorischen Ganglienzellen, die die normale Adaptionsleistung der sensorischen Transduktion in Hautrezeptoren ("Tastsinn") betreffen. Es wird angenommen, dass sich bei bestimmten Hörstörungen auch Auffälligkeiten im Bereich des Tastsinns nachweisen lassen. Um die sensorische Qualität "tasten" zu überprüfen und Normwerte zu erheben, wurden zunächst hörgesunde und sehende Probanden (n=34) mit hörgesunden blinden Probanden (n=38) verglichen. Die Überprüfung der taktilen Wahrnehmung und die Bestimmung der Wahrnehmungsschwelle erfolgten mit dem Tactile acuity cube. Weiterhin wurde in der Gruppe der hörgesunden und sehenden Probanden die Auflösungsschwelle von Vibrationen detektiert. Die beiden Gruppen wurden anschließend im Hinblick auf die Wahrnehmungsschwelle: a.) kleiner Finger der dominanten Hand, b.) Zeigefinger der dominanten Hand untersucht. Weiterhin wurde in der Gruppe der sehbehinderten Probanden der dominante Finger, der zum Lesen der Brailleschrift verwendet wurde, mit dem anderen Zeigefinger verglichen. Die Ergebnisse zeigen in der Gruppe der hörgesunden und sehenden Probanden eine hochsignifikante Korrelation im Bereich der taktilen Wahrnehmungsschwelle mit dem Tactile acutiy cube im Vergleich zur erhobenen Vibrationsdetektionsschwelle. Der sensorische Vergleich der beiden Gruppen mit dem Tactile acuity cube zeigt keine signifikanten Unterschiede im Bereich der untersuchten Eigenschaften.
- Published
- 2007
7. Bamboo Nodes als Erstmanifestation eines systemischen Lupus erythematodes
- Author
-
Seipelt, M, Herzberg, C, Bohlender, JE, and Gross, M
- Subjects
ddc: 610 - Abstract
In der Literatur sind Bamboo Nodes, meist symmetrisch vorhandene bindegewebige Verdickungen der Stimmlippen im mittleren Drittel, als eine von vielen klinischen Manifestationsformen unterschiedlichster Autoimmunerkrankungen beschrieben. Wir berichten über eine 22-jährige Patientin, die mit der Verdachtsdiagnose eines REINKE-Ödems in unsere Sprechstunde überwiesen wurde. Die Eigenanamnese war im wesentlichen leer, auf gezielte Nachfrage räumte die Patientin Schmerzen in den distalen Interphalangealgelenken der Finger, insbesondere nach längerer manueller Arbeit, ein. In der klinischen Untersuchung zeigten sich symmetrische Veränderungen der Stimmlippen im mittleren Drittel im Sinne von Bamboo Nodes, für REINKE-Ödeme boten sich keinerlei Hinweise. Dem somit aufgekommenen Anfangsverdacht auf eine Autoimmunkrankheit folgend veranlassten wir eine weiterführende rheumatologische Diagnostik, in deren Ergebnis ein systemischer Lupus erythematodes gesichert wurde, der einer immunmodulatorischen Glukokortikoid- und Hydroxychloroquintherapie bedurfte und woraufhin ein Regime regelmäßiger labor- und funktionsdiagnostischer Kontrollen z.B. der Nierenfunktion zur Prophylaxe einer Niereninsuffizienz begonnen wurde.
- Published
- 2007
8. Mitochondriale Mutationen in einer Kohorte von 6500 Kindern mit permanenter Hörstörung
- Author
-
Spormann-Lagodzinski, M, Kain, S, Kreutz, R, Bohlender, JE, König, O, and Gross, M
- Subjects
ddc: 610 ,otorhinolaryngologic diseases - Abstract
The ototoxic effects of aminoglycoside antibiotics are well known. A mitochondrial mutation (A1555G) is responsible for a maternally inherited hypersensitivity to aminoglycosides causing an antibiotic-induced ototoxicity with non-syndromic hearing loss.The present study reports on the moleculargenetic findings of the deafness-associated mitochondrial A1555G mutation from a German population of 178 children and their relatives in a cohort of 6500 children collected by the German Registry for Hearing Loss in Children (DZH). The diagnosis is made by including anamnestic factors for non-syndromic hearing loss, hearing impaired mother or further female relatives with non-syndromic hearing impairment. Exclusion criteria were e.g. dysmorphism, prenatal rubella or cytomegaly or treatment with other ototoxic drugs.From our data, aminoglycoside induced hearing loss due to A1555G mutation does not seem to be an important risk factor for communication related hearing impairment in our cohort. The mitochondrial polymorphism A1555G was not found in any of the studied individuals neither in patients nor in the controll-group. The A1555G polymorphism seems to be not very common in Caucasian individuals. Because of the low likelihood for hearing loss due to inherited aminoglycoside hypersensitivity a general routine screening for a mitochondrial A15555G mutation does not need to be recommended.
- Published
- 2005
9. An unusual case of idiopathic arterial calcification with a combined hearing loss
- Author
-
Bohlender, JE, Niehues, SM, Spormann-Lagodzinski, ME, König, O, and Gross, M
- Subjects
ddc: 610 ,otorhinolaryngologic diseases ,sense organs - Abstract
Idiopathic infantile arterial calcification (IIAC; OMIM 208000) is a rare congenital, fatal disesase. It is phenotypically characterized by periarticular calcification and calcification of the internal elastic lamina of muscular arteries and myointimal proliferation. Systemic lowering of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) activity and inorganic pyrophosphate levels is related to IIAC. We report the case of a 5 year old boy with IIAC syndrome born to consanguineous parents. Homozygosity for a mutation at the ENNP1 locus resulting in the amino acid change R774C was recently described .In addition to the the phenotypically characteristics features of IIAC we found ear-lobe calcifications and a bilateral combined hearing loss.Impedance audiometry was normal. Stapedius reflex was absent in both ears. No otoacoustic emissions (DPOAEs, TEOAEs) were detected. A combined bilateral hearing loss in pure tone audiometry was reflected by the results of the auditory brain stem responses (ABRs). In addition to the hearing impairment a computed tomography of the temporal bone showed abnormalities including calcified and abnormal middle ear ossicles with missing articulations and an inner ear malformation with dehiscence of the right anterior semicircular canal. According to the literature the presence of hearing loss and the temporal bone malformation has not previously been documented in IIAC.
- Published
- 2005
10. Kartierung eines neuen Genlocus auf Chromosom 13q34-qter bei autosomal dominanter nicht-syndromaler Hörstörung
- Author
-
Bohlender, JE, Bönsch, D, Deufel, T, Lamprecht-Dinnesen, A, and Gross, M
- Subjects
ddc: 610 - Abstract
Bei einer großen Familie (MS-DFN 0001) mit nicht-syndromaler Hörstörung und autosomal-dominantem Erbgang wurde eine genetische Kopplungsanalyse durchgeführt. Dabei wurden alle bisher für diese Erkrankung bekannten autosomal dominanten Loci (DFNA 1-44) ausgeschlossen. Den höchsten 2-Punkt - Lod score erreichte dabei der Indexmarker D13S285 mit einem ermittelten Wert von 2.96. In der Folge wurde die kritische Region für den neuen Locus DFNA33 auf ein 6-cM großes Intervall auf Chromosom 13q34-qter eingegrenzt, sie enthält eine Reihe von plausiblen Kandidatengenen: SOX1, TFDP1und ATP4B. Letzteres Gen zeigt Verwandtschaft mit ATP2b2, ein analoges Gen der Maus bei einer murinen Hörstörung (dfw), und wird derzeit mit Vorrang untersucht.
- Published
- 2003
11. Melatonin als Alternative zur Sedierung bei Durchführung einer Hirnstammaudiometrie
- Author
-
Schmidt, CM, Bohlender, JE, Deuster, D, Matulat, P, Knief, A, Otto, H, Lamprecht-Dinnesen, A, and Gross, M
- Subjects
ddc: 610 - Abstract
Die Hirnstammaudiometrie als eines der wichtigsten Untersuchungsverfahren in der Pädaudiologie gelingt insbesondere bei Säuglingen und Kleinkindern oft nur in Sedierung oder Vollnarkose. In der Kinderneurologie wird schon seit einigen Jahren Melatonin zur Schlafinduktion vor EEG- Untersuchungen eingesetzt. Melatonin als Hormon, das den Schlaf- Wach- Rhytmus reguliert, induziert einen natürlichen Schlaf ohne die Risiken einer Sedation. Nebenwirkungen sind nicht bekannt. Wir haben bei 30 Kindern von Februar bis Mai 2003 BERA- Untersuchungen im Schlaf bei vorheriger Melatoningabe durchgeführt. Bei 28 von 30 Kindern gelang eine Klick- BERA- Untersuchung, bei 23 eine anschließende Notched- Noise- BERA. Das untersuchte Kollektiv umfasste Hörstörungen von Normal- bis Resthörigkeit. Die Gabe von Melatonin erscheint uns als gute Alternative zur Sedation oder Vollnarkose mit hoher Erfolgsquote. Das Verfahren hat eine hohe Akzeptanz bei den Elten der betroffenen Kinder und beschleunigt im klinischen Alltag die Diagnosestellung der kindlichen Schwerhörigkeit.
- Published
- 2003
12. Melatonin als Alternative zur Sedierung bei Durchführung einer Hirnstammaudiometrie
- Author
-
Schmidt, CM, primary, Bohlender, JE, additional, Knief, A, additional, and Dinnesen, AG, additional
- Published
- 2004
- Full Text
- View/download PDF
13. [Gastric vs. supragastric belching, singultus, aerophagia, and differential diagnoses : An interdisciplinary perspective for otorhinolaryngologists].
- Author
-
Runggaldier D, Adam R, Ermanni C, Colotto-Vith U, van Beek MEF, Posovszky C, Righini Grunder F, Pohl D, and Bohlender JE
- Subjects
- Humans, Diagnosis, Differential, Patient Care Team, Eructation therapy, Eructation diagnosis, Eructation physiopathology, Eructation etiology, Aerophagy diagnosis, Aerophagy therapy
- Abstract
Belching is the act of expelling air from the stomach or esophagus into the pharynx. Although the process is regarded as physiological, excessive belching might be associated with a significant burden for affected patients in the sense of a belching disorder. Diagnosis of a belching disorder is often challenging, and its differentiation from other conditions such as rumination syndrome, singultus, or aerophagia can be difficult. Treatment of these disorders also represents a challenge for otorhinolaryngologists. Hence, the aim of this review is to provide an interdisciplinary overview of these clinical syndromes and provide practical guidance for their diagnosis and treatment., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
14. Validity and Reliability of the German Vocal Fatigue Index in Adults With Voice Disorders.
- Author
-
Stappenbeck LE, Bartel S, Bohlender JE, and Brockmann-Bauser M
- Subjects
- Humans, Middle Aged, Male, Female, Reproducibility of Results, Adult, Prospective Studies, Aged, Germany, Surveys and Questionnaires standards, Severity of Illness Index, Language, Voice Quality, Voice Disorders diagnosis, Voice Disorders physiopathology
- Abstract
Purpose: Vocal fatigue-related symptoms, frequent in patients with voice disorders, are reliably quantifiable with the Vocal Fatigue Index (VFI) in several languages. The main aim of this work was to investigate the content and construct validity of the German Vocal Fatigue Index (VFI-D) by comparison with the German Voice Handicap Index 9 international (VHI9i) and the Vocal Tract Discomfort Scale (VTD). Moreover, the scale and retest reliability were investigated., Method: In a prospective cohort study at two tertiary care hospitals, 93 adults with all types of voice complaints filled out the VFI-D, the VHI-9i, and the VTD. Eighty-one adults ( M
age = 53.5 years, SD = 15.7) completed them one time, and additional 12 patients ( Mage = 53.8 years, SD = 15.6) did a test-retest, completed them twice at an interval of 1 week. The validity was assessed by Spearman's rho and Mokken scaling and the reliability by a factor analysis and a two-tailed t test., Results: Mokken scaling has proven the VFI-D as one-dimensional questionnaire (one cluster, r = .95). All VFI-D items could be assigned to one of three factors according to principal component and principal axis factor analysis. Although Factor 1 related best to the VHI9i (∅ rs = .76) and Factor 2 to the VTD (∅ rs = .74), Factor 3 correlated moderately with the VHI9i ( rs = .34) and weakly with the VTD ( rs = .25). Results from the first and second VFI-D completion agreed strongly ( t = -1.78, p = .10)., Conclusions: In this study, the content and construct validity of the VFI-D were confirmed. Also, both scale reliability with identical factors as those in the original study and retest reliability were verified. The VHI9i and VTD were highly indicative of VFI-D Factors 1 and 2, respectively. No correlation between Factor 3 and the other questionnaires was determined. Future research should evaluate which characteristics are specific to vocal fatigue versus general voice disorder-related symptoms.- Published
- 2024
- Full Text
- View/download PDF
15. [Help, I can't burp! A brief overview and case discussion of retrograde cricopharyngeal dysfunction].
- Author
-
Runggaldier D, Colotto-Vith U, Pohl D, and Bohlender JE
- Subjects
- Humans, Cricoid Cartilage surgery, Manometry, Pharyngeal Muscles, Deglutition Disorders diagnosis, Deglutition Disorders etiology, Deglutition Disorders therapy
- Abstract
In this short communication, we discuss the recently described syndrome of retrograde cricopharyngeal dysfunction (R-CPD) with its first description in 2019 by the laryngologist Dr. Bastian. Diagnosis is generally based on typical clinical symptoms, e.g., the inability to belch, a bloated abdomen and retrosternal gurgling noises. We also describe high-resolution esophageal manometry as a new tool to further secure the diagnosis of R‑CPD, as well as therapeutic options such as botulinum toxin injections in the cricopharyngeal muscle or cricopharyngeal myotomy and the published data thereon., (© 2023. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
16. Consensus for voice quality assessment in clinical practice: guidelines of the European Laryngological Society and Union of the European Phoniatricians.
- Author
-
Lechien JR, Geneid A, Bohlender JE, Cantarella G, Avellaneda JC, Desuter G, Sjogren EV, Finck C, Hans S, Hess M, Oguz H, Remacle MJ, Schneider-Stickler B, Tedla M, Schindler A, Vilaseca I, Zabrodsky M, Dikkers FG, and Crevier-Buchman L
- Subjects
- Humans, Voice Quality, Treatment Outcome, Voice, Otolaryngology, Laryngeal Diseases
- Abstract
Introduction: To update the European guidelines for the assessment of voice quality (VQ) in clinical practice., Methods: Nineteen laryngologists-phoniatricians of the European Laryngological Society (ELS) and the Union of the European Phoniatricians (UEP) participated to a modified Delphi process to propose statements about subjective and objective VQ assessments. Two anonymized voting rounds determined a consensus statement to be acceptable when 80% of experts agreed with a rating of at least 3/4. The statements with ≥ 3/4 score by 60-80% of experts were improved and resubmitted to voting until they were validated or rejected., Results: Of the 90 initial statements, 51 were validated after two voting rounds. A multidimensional set of minimal VQ evaluations was proposed and included: baseline VQ anamnesis (e.g., allergy, medical and surgical history, medication, addiction, singing practice, job, and posture), videolaryngostroboscopy (mucosal wave symmetry, amplitude, morphology, and movements), patient-reported VQ assessment (30- or 10-voice handicap index), perception (Grade, Roughness, Breathiness, Asthenia, and Strain), aerodynamics (maximum phonation time), acoustics (Mean F0, Jitter, Shimmer, and noise-to-harmonic ratio), and clinical instruments associated with voice comorbidities (reflux symptom score, reflux sign assessment, eating-assessment tool-10, and dysphagia handicap index). For perception, aerodynamics and acoustics, experts provided guidelines for the methods of measurement. Some additional VQ evaluations are proposed for voice professionals or patients with some laryngeal diseases., Conclusion: The ELS-UEP consensus for VQ assessment provides clinical statements for the baseline and pre- to post-treatment evaluations of VQ and to improve collaborative research by adopting common and validated VQ evaluation approach., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2023
- Full Text
- View/download PDF
17. [Patient-reported outcome measures for assessing health-related quality of life in patients with voice and swallowing disorders].
- Author
-
Bohlender JE
- Subjects
- Humans, Quality of Life, Deglutition, Surveys and Questionnaires, Patient Reported Outcome Measures, Deglutition Disorders diagnosis, Deglutition Disorders therapy, Voice, Voice Disorders diagnosis, Voice Disorders therapy
- Abstract
Standardized and validated patient surveys in the form of questionnaires are becoming increasingly important in otorhinolaryngology. Subjective symptoms and functional limitations but also health-related quality of life are assessed with so-called patient-reported outcome measures (PROMs). Besides patient history and objective findings, these questionnaires can be applied as another important source for ensuring the quality of patient-centered care. In German-speaking countries there are now several PROMs that specifically ask for the patient perspective on voice and swallowing disorders. For patients with voice disorders the following questionnaires based on the Voice Handicap Index (VHI), which are also used internationally, are mainly applied: VHI-30, VHI-12i, and VHI-9i. In the field of oropharyngeal dysphagia, the German versions of the Eating Assessment Tool-10 (EAT-10), des Sydney Swallow Questionnaire SSQ‑G, the Swallowing Quality of Life Questionnaire (SWAL-QoL), and the MD Anderson Dysphagia Inventory (MDADI) are currently mostly used., (© 2023. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
18. [Current possibilities and challenges in the treatment of laryngopharyngeal reflux].
- Author
-
Runggaldier D, van Schie B, Marti S, and Bohlender JE
- Subjects
- Humans, Proton Pump Inhibitors therapeutic use, Pharynx, Hoarseness, Laryngopharyngeal Reflux, Larynx
- Abstract
Laryngopharyngeal reflux (LPR) is characterized by backflow of gastric or gastroduodenal content and gases into the upper aerodigestive tract, which can damage the mucus membranes of the larynx and pharynx. It is associated with a variety of symptoms such as retrosternal burning and acid regurgitation, or other unspecific symptoms such as hoarseness, globus sensation, chronic cough, or mucus hypersecretion. Due to the lack of data and the heterogeneity of studies, diagnosis of LPR is problematic and challenging, as recently discussed. Moreover, the different therapeutic approaches are also discussed controversially in the face of the poor evidence base, and include pharmacologic and conservative dietary measures. Hence, in the following review, the available options for treatment of LPR are critically discussed and summarized for daily clinical use., (© 2023. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
19. [Transcultural German translation of the reflux symptom score-12 questionnaire].
- Author
-
Bruhn J, Brockmann-Bauser M, Swing T, Bohlender JE, and Runggaldier D
- Subjects
- Humans, Reproducibility of Results, Quality of Life, Surveys and Questionnaires, Laryngopharyngeal Reflux diagnosis, Esophagitis, Peptic
- Abstract
In addition to clinical and instrumental methods as well as medical history, questionnaires are well-established tools in the diagnosis of laryngopharyngeal reflux (LPR). Recently, the reflux symptom score (RSS) as well as the short version of it, the RSS-12, which are self-administered patient-reported outcome questionnaires, have been published as an alternative to the well-established reflux symptom index (RSI). The RSS-12 assesses severity and frequency of LPR symptoms as well as the impact on quality of life and has been shown to have high reliability and validity. However, so far, only French, English, and Portuguese versions of the RSS-12 have been published. Hence, the aim of this study was to prepare a transcultural German translation of the RSS-12 (G-RSS-12) to provide a new clinical and scientific tool for the diagnosis of LPR in German-speaking regions., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
20. [Prolonged ulcerative laryngitis].
- Author
-
Reetz S, Brockmann-Bauser M, and Bohlender JE
- Subjects
- Hoarseness, Humans, Laryngoscopy, Vocal Cords, Dysphonia diagnosis, Dysphonia etiology, Laryngitis diagnosis
- Abstract
Background: Prolonged ulcerative laryngitis is a rare, benign inflammatory alteration of the larynx that persists for months. The laryngoscopic findings suggest a malignant process and can therefore be a challenge for the treating ear, nose and throat (ENT) physician., Objectives: Presentation of the current database to provide an overview of the etiology, progress and treatment for everyday clinical practice., Methods: Three case studies from the Department of Phoniatrics and Speech Pathology of the ENT Department, University Hospital Zurich, Switzerland, are presented. Analysis and discussion of the current literature base and of case reports in the English literature., Results: The etiology and predisposing factors for this disease are unclear. Previous respiratory infection with cough and dysphonia seems to be the most common cause. Biopsies should be avoided., Conclusions: The typical laryngoscopic findings show corresponding circumscribed lancet-shaped ulcerations in the middle third of the vocal fold. The course of the disease appears to be self-limiting and without permanent structural consequences. Therefore, good patient education and close laryngoscopic follow-up should be performed., (© 2021. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
21. [The German Sydney Swallow Questionnaire : Reliability and validity in patients with oropharyngeal dysphagia].
- Author
-
Bohlender JE, Frick S, Colotto U, Hotzenköcherle S, and Brockmann-Bauser M
- Subjects
- Adult, Female, Humans, Male, Quality of Life, Reproducibility of Results, Surveys and Questionnaires, Deglutition Disorders diagnosis, Head and Neck Neoplasms
- Abstract
Background: The Sydney Swallow Questionnaire (SSQ) is a self-report inventory assessing subjective symptoms of oropharyngeal dysphagia with strong content, construct, discriminant, and predictive validity and test-retest reliability in a range of patient populations., Objective: The main aim of this work was to assess the validity and reliability of the German version of the SSQ (SSQ-G)., Materials and Methods: In a cross-validation study, 48 adult German-speaking patients (12 women, 36 men) with neurogenic (n = 16), structural (n = 16), and functional (n = 16) oropharyngeal dysphagia were assessed with the SSQ‑G and the MD Anderson Dysphagia Inventory (MDADI). Cronbach's α was applied to assess the reliability. Criteria and construct validity were investigated using the Spearman correlation coefficient., Results: With Cronbach's α = 0.94, the internal consistency of the SSQ‑G was excellent. The SSQ‑G questions 1 and 17 showed a moderately significant and highly significant correlation coefficient of -0.43 and -0.45, respectively, with MDADI question 1 (p < 0.5, p < 0.001). Between questions 8, 11, and 12 of the SSQ‑G and questions 7, 13, and 10 of the MDADI, coefficients of -0.48 to -0.55 showed a moderate to strong highly significant correlation (p < 0.001). Thus, the reliability and criterion and construct validity were statistically confirmed., Conclusion: The German version of the SSQ (SSQ-G) allows a reliable and valid assessment of functional swallowing difficulties. In combination with questionnaires on symptom-specific quality of life, such as the MDADI, a more differentiated clinical analysis of swallowing problems is thus possible., (© 2021. The Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
22. [Current possibilities and challenges in the diagnosis of laryngopharyngeal reflux].
- Author
-
Runggaldier D, Hente J, Brockmann-Bauser M, Pohl D, and Bohlender JE
- Subjects
- Esophageal pH Monitoring, Humans, Pepsin A, Saliva, Laryngopharyngeal Reflux diagnosis
- Abstract
Laryngopharyngeal reflux (LPR) is defined as backflow of gastral or gastroduodenal content into the upper aerodigestive tract and characterized by a variety of unspecific symptoms such as chronic cough, globus sensation, or mucus hypersecretion. Due to the lack of a gold standard and the heterogeneity of studies, the diagnosis of LPR is still problematic and challenging. However, in patients with characteristic symptoms and endoscopic findings, with an increased reflux symptom index, a pathologic reflux finding score (RFS), pathologic 24 h esophageal or oropharyngeal pH monitoring, and without any other underlying condition, the diagnosis of LPR is probable. In the following review, we critically discuss the abovementioned methods as well as more recent tools such as measurements of pepsin concentrations in the saliva for diagnosis of LPR., (© 2021. The Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
23. [Office-based phonosurgery].
- Author
-
Bohlender JE
- Subjects
- Ambulatory Surgical Procedures, Humans, Laryngoscopy, Laryngeal Diseases surgery, Laryngoplasty, Larynx surgery, Laser Therapy
- Abstract
Significant and new impulses regarding the treatment concept for outpatient phonosurgery on unsedated patients are currently coming from various Anglo-American authors. These "office-based procedures" have been propagated as an alternative to many conventional surgical interventions under anesthesia. The main reason for this remarkable development is the use of new endoscopic techniques in combination with photoangiolytic laser (KTP and blue laser), which allow safe and efficient phonosurgical procedures. Patient acceptance is high since outpatient procedures are considered to have a lower surgical risk. Despite the widespread euphoria, there is a lack of studies evaluating the medical decision criteria and safety management of office-based laryngeal surgery., (© 2021. The Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
24. Fundamental Frequency and Intensity Effects on Cepstral Measures in Vowels from Connected Speech of Speakers with Voice Disorders.
- Author
-
Sampaio MC, Bohlender JE, and Brockmann-Bauser M
- Subjects
- Adult, Brazil, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Retrospective Studies, Speech Acoustics, Speech Production Measurement, Voice Quality, Dysphonia diagnosis, Dysphonia therapy, Speech
- Abstract
Objective: Cepstral peak prominence (CPP) and smoothed CPP (CPPS) have been described as reliable parameters to detect overall dysphonia in standardized connected speech samples. Recent studies indicate that vocal intensity (sound pressure level, SPL) and fundamental frequency (f
o ) changes may influence cepstral measurement results in healthy speakers. The main aim of the present work was to investigate the effects of prosody related SPL and fo variations on cepstral measures in speech of adults with voice disorders., Study Design: Retrospective cross-sectional study., Methods: Recordings of CAPE-V sentences from 27 voice disordered Brazilian Portuguese speakers (19 women, eight men) with a mean age of 45 years (SD = 13) were investigated. Five /a/ vowels were manually extracted from stressed syllables in different positions. Voice fo (Hz), SPL (dBA), CPP (dB), and CPPS (dB) were computed using PRAAT. Statistical analysis included Linear Mixed Models with ANCOVA and Bonferroni post hoc tests., Results: Voice SPL as single factor and combined with fo had a highly significant effect (P ≤ 0.001), while fo alone had no significant impact on both CPP and CPPS (P ≥ 0.77). Voice fo , SPL, CPP, and CPPS of the first vowel were all significantly lower than of the last vowel (P ≤ 0.03)., Conclusion: In vowel samples from connected speech of adults with voice disorders, we observed better CPP and CPPS in higher voice SPL alone and combined with higher fo . Further, the vowel position influenced the present results. A larger clinical study should confirm how prosody related SPL and fo and vowel position effects could be controlled for in connected speech samples., (Copyright © 2019 The Voice Foundation. Published by Elsevier Inc. All rights reserved.)- Published
- 2021
- Full Text
- View/download PDF
25. Effects of Vocal Intensity and Fundamental Frequency on Cepstral Peak Prominence in Patients with Voice Disorders and Vocally Healthy Controls.
- Author
-
Brockmann-Bauser M, Van Stan JH, Carvalho Sampaio M, Bohlender JE, Hillman RE, and Mehta DD
- Subjects
- Adult, Case-Control Studies, Female, Humans, Retrospective Studies, Speech Acoustics, Voice Quality, Dysphonia diagnosis, Voice Disorders diagnosis
- Abstract
Objective: Cepstrum-based voice measures, such as smoothed cepstral peak prominence (CPPS), are influenced by voice sound pressure level (SPL) in vocally healthy adults. Since it is unclear if similar effects hold in voice disordered adults and how these interact with natural fundamental frequency (f
o ) changes, this study examines voice SPL and fo effects on CPPS in women with vocal hyperfunction and vocally healthy controls., Study Design: Retrospective matched case-control study., Methods: Fifty-eight women with vocal hyperfunction were individually matched with 58 vocally healthy women for occupation and approximate age. The patient group comprised women exhibiting phonotraumatic vocal hyperfunction associated with vocal fold nodules (n = 39) or polyps (n = 5), and nonphonotraumatic vocal hyperfunction associated with primary muscle tension dysphonia (n = 14). All participants sustained the vowel /a/ at soft, comfortable, and loud loudness conditions. Voice SPL, fo , and CPPS (dB) were computed from acoustic voice recordings using Praat. The effects of loudness condition, measured voice SPL, and fo on CPPS were assessed with linear mixed models. Pairwise correlations among voice SPL, fo , and CPPS were assessed using multiple regression analysis., Results: Increasing voice SPL correlated significantly (P < 0.001) with higher CPPS in both patient (r2 = 0.53) and normative groups (r2 = 0.45). fo had statistically significant effects on CPPS (P < 0.001), but with a weak relation for the patient (r2 = 0.02) and control groups (r2 = 0.05)., Conclusions: In women with and without voice disorder, CPPS is highly affected by the individual's voice SPL in vowel phonation. Future studies could investigate how these effects should be controlled for to improve the diagnostic value of acoustic-based cepstral measures., (Copyright © 2019 The Voice Foundation. Published by Elsevier Inc. All rights reserved.)- Published
- 2021
- Full Text
- View/download PDF
26. Assessment of Surgical Complications With Respect to the Surgical Indication: Proposal for a Novel Index.
- Author
-
Morand GB, Anderegg N, Kleinjung T, Bohlender JE, Veraguth D, Broglie MA, Holzmann D, Huber AM, Röösli C, and Soyka MB
- Abstract
Introduction: The Clavien-Dindo classification is a broadly accepted surgical complications classification system, grading complications by the extent of therapy necessary to resolve them. A drawback of the method is that it does not consider why the patient was operated on primarily. Methods: We designed a novel index based on Clavien-Dindo but with respect to the surgical indication. We surveyed an international panel of otolaryngologists who filled out a questionnaire with 32 real case-inspired scenarios. Each case was graded for the surgical complication, surgical indication, and a subjective rating whether the complication was acceptable or not. Results: Seventy-seven otolaryngologists responded to the survey. Mean subjective rating and surgical complication grading for each scenario showed an inverse correlation ( r
2 = 0.147, p = 0.044). When grading the surgical complication with respect to the surgical indication, the correlation with the subjective rating increased dramatically ( r2 = 0.307, p = 0.0022). Conclusion: We describe a novel index grading surgical complications with respect to the surgical indication. In our survey, most respondents judged a complication as acceptable or not according to its grade but kept in mind the surgical indication. This subjective judgment could be quantified with our novel index., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Morand, Anderegg, Kleinjung, Bohlender, Veraguth, Broglie, Holzmann, Huber, Röösli and Soyka.)- Published
- 2021
- Full Text
- View/download PDF
27. Immediate Lip Trill Effects on the Standard Diagnostic Measures Voice Range Profile, Jitter, Maximum Phonation Time, and Dysphonia Severity Index.
- Author
-
Brockmann-Bauser M, Balandat B, and Bohlender JE
- Subjects
- Female, Humans, Lip, Phonation, Voice Quality, Voice Training, Dysphonia diagnosis, Singing
- Abstract
Objectives: Semi-occluded vocal tract exercises are widely applied to improve vocal performance in speakers, singers, and voice patients. This study investigates immediate lip trill effects on standard voice assessment measures including voice range profiles, jitter, maximum phonation time, and Dysphonia Severity Index in vocally healthy women., Study Design: Experimental study., Setting: Otolaryngology clinic within tertiary hospital., Subjects and Methods: Twenty-five vocally healthy women between 19 and 58 years (mean 38.4) were assessed before and after 3 minutes of standardized lip trill training combined with defined voice fundamental frequency and intensity modulations. Main outcome measures were fundamental frequency (F
0 ) during counting (F0 counting), the singing voice range profile parameters minimum, maximum and range of F0 and voice sound pressure level (voice SPL), jitter (%), maximum phonation time (MPT), and the Dysphonia Severity Index (DSI). Wilcoxon signed rank test was applied to determine significant changes after exercise., Results: After exercise the singing F0 and SPL range significantly increased from 549 (SD 217) to 612 (238) Hz and 45.1 (10.1) to 47.3 (9.8) dBA, resepctively (P<0.05). Maximum voice SPL significantly increased from 90.9 (10.3) to 94 (9.7) dBA (P<0.05). Mean F0 during counting showed a highly significant increase from 198 (SD 25.6) to 209 Hz (SD 25.4, P<0.01). No significant changes were found for all other parameters., Conclusions: In vocally healthy women, lip trill training immediately facilitates increases in mean F0 during counting, and singing F0 and SPL range. Future studies should investigate, if changes to these parameters indicate immediate responsiveness to voice exercise also in voice patients, and if these findings transfer to long-term effects through prolonged training., (Copyright © 2019 The Voice Foundation. Published by Elsevier Inc. All rights reserved.)- Published
- 2020
- Full Text
- View/download PDF
28. Effects of Fundamental Frequency, Vocal Intensity, Sample Duration, and Vowel Context in Cepstral and Spectral Measures of Dysphonic Voices.
- Author
-
Sampaio M, Vaz Masson ML, de Paula Soares MF, Bohlender JE, and Brockmann-Bauser M
- Subjects
- Brazil, Humans, Phonation, Retrospective Studies, Speech Production Measurement, Speech Acoustics, Voice Quality
- Abstract
Purpose Smoothed cepstral peak prominence (CPPS) and harmonics-to-noise ratio (HNR) are acoustic measures related to the periodicity, harmonicity, and noise components of an acoustic signal. To date, there is little evidence about the advantages of CPPS over HNR in voice diagnostics. Recent studies indicate that voice fundamental frequency (F0) and intensity (sound pressure level [SPL]), sample duration (DUR), vowel context (speech vs. sustained phonation), and syllable stress (SS) may influence CPPS and HNR results. The scope of this work was to investigate the effects of voice F0 and SPL, DUR, SS, and token on CPPS and HNR in dysphonic voices. Method In this retrospective study, 27 Brazilian Portuguese speakers with voice disorders were investigated. Recordings of sustained vowels (SVs) /a:/ and manually extracted vowels (EVs) /a/ from Consensus Auditory-Perceptual Evaluation of Voice sentences were acoustically analyzed with the Praat program. Results There was a highly significant effect of F0, SPL, and DUR on both CPPS and HNR ( p < .001), whereas SS and vowel context significantly affected CPPS only ( p < .05). Higher SPL, F0, and lower DUR were related to higher CPPS and HNR. SVs moderately-to-highly correlated with EVs for CPPS, whereas HNR had few and moderate correlations. In addition, CPPS and HNR highly correlated in SVs and seven EVs ( p < .05). Conclusion Speaking prosodic variations of F0, SPL, and DUR influenced both CPPS and HNR measures and led to acoustic differences between sustained and excised vowels, especially in CPPS. Vowel context, prosodic factors, and token type should be controlled for in clinical acoustic voice assessment.
- Published
- 2020
- Full Text
- View/download PDF
29. Cervical Spine Disability in Correlation with Subjective Voice Handicap in Patients With Voice Disorders: A Retrospective Analysis.
- Author
-
Langenfeld A, Bohlender JE, Swanenburg J, and Brockmann-Bauser M
- Subjects
- Activities of Daily Living, Adult, Aged, Aged, 80 and over, Cervical Vertebrae, Disability Evaluation, Dysphonia diagnosis, Dysphonia physiopathology, Female, Humans, Male, Middle Aged, Neck Pain diagnosis, Neck Pain physiopathology, Retrospective Studies, Young Adult, Dysphonia etiology, Neck Muscles physiopathology, Neck Pain complications, Voice Quality
- Abstract
Objective: Neck muscle dysfunction has been considered as risk factor or consequence of voice disorders. This study investigates the correlation between neck and voice-related subjective symptoms in patients with voice disorders., Study Design: Retrospective case-control study., Methods: 100 adult patients (59 female and 41 male) over 18 years with a mean age of 50.01 years (SD 16, range 24-87), of which 68 were under 60 years, were included. 50 patients had organic voice pathologies and 50 functional dysphonia. Outcome measures were the Voice Handicap Index 9 international (VHI-9i) and the Neck Disability Index (NDI-G). Spearman rank order coefficient was applied to determine the correlation between overall and single item VHI and NDI results. Subanalyses were done for functional vs. organic disorder, gender and age ± 60 years., Results: Mean overall VHI-9i (13.93, SD = 7.81, range = 0-31) and mean NDI-G (6.07, SD = 7.71, range = 0-43) showed a significant mild correlation (r
s = 0.220, P = 0.02). Split into subgroups the relation was stronger in patients with organic pathologies (rs = 0.297, P = 0.03), but not significant in functional disorders (r = 0.148, P = 0.30). There was a moderate relation in men (rs = 0.317, P = 0.04). Single item correlation was highest between VHI-9i item P4 (physiological) and NDI-G item reading (cognitive functioning) (rs = 0.480, P = 0.002)., Conclusion: Specifically patients with organic voice disorders showed increased voice symptoms with the presence of neck dysfunction. This indicates a risk for a functional imbalance of the muscles surrounding the larynx, which in extreme cases may hinder functional voice rehabilitation even after phonosurgery. Therefore, neck dysfunction should be considered in voice diagnostics., (Copyright © 2018 The Voice Foundation. Published by Elsevier Inc. All rights reserved.)- Published
- 2020
- Full Text
- View/download PDF
30. [Pretesting of the German Vocal Fatigue Index (VFI-D)-transcultural translation and cross validation].
- Author
-
Stappenbeck LE, Bohlender JE, and Brockmann-Bauser M
- Subjects
- Humans, Reproducibility of Results, Severity of Illness Index, Surveys and Questionnaires, Dysphonia complications, Dysphonia diagnosis, Voice Disorders etiology, Voice Quality
- Abstract
Background: In clinical routine, vocal fatigue is a common symptom in patients with dysphonia., Objective: The aim of this study was to conduct a transcultural translation of the Vocal Fatigue Index (VFI), a standardized subjective questionnaire. Furthermore, pretesting and prevalidation were performed in 20 subjects, with comparison to the Voice Handicap Index (VHI‑9i) and the Vocal Tract Discomfort Scale (VTD)., Materials and Methods: The translation, content review, and pretest of the German Vocal Fatigue Index (VFI-D) was divided into four sections: 1. transcultural translation, 2. expert voting on comprehensibility, 3. test of comprehensibility through cognitive interviews in 15 participants, 4. pretest of the VFI‑D with cross validation compared to VHI‑9i and VTD in 20 subjects. This process corresponds to current standards for transcultural translation and adaptation of questionnaires., Results: According to expert voting and cognitive testing, the VFI‑D is correct and comprehensible (intercoder reliability κ = 0.66). The factor analysis revealed three distinguishable parts: VFI‑D part 1 correlates strongly with VHI‑9i and VTD, VFI‑D part 2 with VTD only (rho ≈ 0.800 each), and VFI‑D part 3 correlates only weakly with VHI‑9i and VTD (rho ≈ 0.585). Thus, convergence and divergence validity are proven., Conclusion: The first German version of the VFI‑D might be a base for further research on symptoms, causes, and treatment options in vocal fatigue. Particularly patients in voice-intensive professions may benefit.
- Published
- 2020
- Full Text
- View/download PDF
31. Do Standard Instrumental Acoustic, Perceptual, and Subjective Voice Outcomes Indicate Therapy Success in Patients With Functional Dysphonia?
- Author
-
Reetz S, Bohlender JE, and Brockmann-Bauser M
- Subjects
- Adult, Aged, Dysphonia diagnosis, Dysphonia physiopathology, Female, Humans, Judgment, Male, Middle Aged, Predictive Value of Tests, Recovery of Function, Reproducibility of Results, Retrospective Studies, Severity of Illness Index, Treatment Outcome, Young Adult, Acoustics, Disability Evaluation, Dysphonia therapy, Speech Acoustics, Speech Perception, Speech Production Measurement, Surveys and Questionnaires, Voice Quality, Voice Training
- Abstract
Objectives: The validity and sensitivity to change of instrumental acoustic measurements in patients with functional dysphonia have been controversially discussed. This work examines combined voice therapy effects on standard acoustic measurements, and if these agree with perceptual and subjective voice outcomes., Study Design: Retrospective study., Methods: Thirty-nine patients (26 women, 13 men) aged 20-70 years (mean: 46.3, standard deviation 12.8) with functional dysphonia were investigated before and after combined voice therapy. Instrumental parameters included mean and range of speaking fundamental frequency (f
o ) and intensity (SPL (dBA)); maximum SPL and mean fo of calling voice; minimum, maximum, range of singing voice fo and SPL, jitter (%), and the Dysphonia Severity Index. Voice Handicap Index-9 international was used for subjective and Grading-Roughness-Breathiness-Asthenia-Strain scale for perceptual assessment. Differences were investigated by Wilcoxon signed ranks test and coherences by Spearman rank correlation coefficient., Results: After treatment, the speaking voice fo range (7-8.13 semitones) and SPL range (12.9-14.85 dB(A)) were significantly larger (P < 0.05). Both parameters were highly correlated (P < 0.001). Subjective symptoms were significantly reduced from a mean Voice Handicap Index-9 international of 15.6-8.6, and all perceptual Grading-Roughness-Breathiness-Asthenia-Strain scale parameters were significantly improved (G: 1.05-0.51) after therapy (P < 0.05). These findings were not associated with any acoustic parameter (P > 0.05)., Conclusions: Significantly improved subjective and perceptual findings verify positive combined voice therapy effects in patients with functional dysphonia. The larger fo and SPL speaking voice range after treatment indicate an altered voice technique. These instrumental measures may be clinical indicators of therapy success and transfer effects., (Copyright © 2019 The Voice Foundation. Published by Elsevier Inc. All rights reserved.)- Published
- 2019
- Full Text
- View/download PDF
32. Acoustic Perturbation Measures Improve with Increasing Vocal Intensity in Individuals With and Without Voice Disorders.
- Author
-
Brockmann-Bauser M, Bohlender JE, and Mehta DD
- Subjects
- Adolescent, Adult, Age Factors, Dysphonia etiology, Dysphonia physiopathology, Female, Humans, Linear Models, Middle Aged, Occupations, Predictive Value of Tests, Reproducibility of Results, Retrospective Studies, Risk Factors, Young Adult, Acoustics, Dysphonia diagnosis, Phonation, Speech Acoustics, Speech Production Measurement methods, Vocal Cords physiopathology, Voice Quality
- Abstract
Objective: In vocally healthy children and adults, speaking voice loudness differences can significantly confound acoustic perturbation measurements. This study examines the effects of voice sound pressure level (SPL) on jitter, shimmer, and harmonics-to-noise ratio (HNR) in adults with voice disorders and a control group with normal vocal status., Study Design: This is a matched case-control study., Methods: We assessed 58 adult female voice patients matched according to approximate age and occupation with 58 vocally healthy women. Diagnoses included vocal fold nodules (n = 39, 67.2%), polyps (n = 5, 8.6%), and muscle tension dysphonia (n = 14, 24.1%). All participants sustained the vowel /a/ at soft, comfortable, and loud phonation levels. Acoustic voice SPL, jitter, shimmer, and HNR were computed using Praat. The effects of loudness condition, voice SPL, pathology, differential diagnosis, age, and professional voice use level on acoustic perturbation measures were assessed using linear mixed models and Wilcoxon signed rank tests., Results: In both patient and normative control groups, increasing voice SPL correlated significantly (P < 0.001) with decreased jitter and shimmer, and increased HNR. Voice pathology and differential diagnosis were not linked to systematically higher jitter and shimmer. HNR levels, however, were statistically higher in the patient group than in the control group at comfortable phonation levels. Professional voice use level had a significant effect (P < 0.05) on jitter, shimmer, and HNR., Conclusions: The clinical value of acoustic jitter, shimmer, and HNR may be limited if speaking voice SPL and professional voice use level effects are not controlled for. Future studies are warranted to investigate whether perturbation measures are useful clinical outcome metrics when controlling for these effects., (Copyright © 2018 The Voice Foundation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
33. Reliable acoustic measurements in children between 5;0 and 9;11 years: Gender, age, height and weight effects on fundamental frequency, jitter and shimmer in phonations without and with controlled voice SPL.
- Author
-
Brockmann-Bauser M, Beyer D, and Bohlender JE
- Subjects
- Age Factors, Body Weight, Child, Child, Preschool, Cohort Studies, Cross-Sectional Studies, Female, Humans, Male, Sex Factors, Phonation physiology, Speech Acoustics, Voice Quality physiology
- Abstract
Background: Current pediatric voice assessment guidelines include instrumental measurements of fundamental frequency (F0) and the perturbation indices jitter and shimmer. In children below 10 years, gender, age, height and weight effects on these parameters have been inconsistently characterized. Recent research in healthy children showed, that differences in habitual speaking voice intensity (voice SPL) under the usual assessment procedure significantly affect jitter and shimmer. These effects were reduced in phonations with controlled voice SPL >80dBA. Reliable measurement methods and description of physiologic influencing factors are essential to identify pathologic voices., Objective: This cross-sectional single cohort study investigates in children between 5;0 and 9;11 years how gender, age, height and weight affect voice F0, jitter and shimmer in phonations at individually "medium" voice intensity (modeling the usual clinical practice) and with controlled voice SPL >80dBA., Subjects and Methods: 68 vocally healthy children (39 f/29 m) aged 5;0-9;11 years provided 3 prolonged phonations of/a/at individually "medium" and controlled voice intensity at ">80dBA" (visual feedback, 10cm distance). F0 (Hz), jitter (%), shimmer (%) and voice SPL (dBA) were determined with PRAAT. Gender, age, height and weight effects without and with controlled voice SPL were assessed by descriptive statistics, Analysis of Variance and Linear Mixed Models., Results: F0 (Hz), jitter (%), shimmer (%) and voice SPL (dBA) were significantly different in medium voice compared to >80dBA (p<0.01). In medium phonations girls had a higher F0 than boys (girls: 276.7(50.7), boys: 261.5(33.7)), but with >80dBA this difference was only minimal (girls: 328.9(52.2), boys 327.9(51.2)). Mean jitter (0.27(0.10)) and shimmer (4.34(1.68)) were smaller and showed less spread (jitter: 0.5(0.26); shimmer: 9.47(3.47)) with >80dBA. Gender, age, height and weight had no significant effects on F0, jitter, shimmer and voice SPL in both phonation types (p-range=0.42-0.99)., Conclusions: Neither without nor with controlled voice SPL there were systematic gender, age, height or weight effects on voice F0, jitter and shimmer. Gender related F0 discrepancies were equalized in phonations with >80dBA. In children below 10 years gender related acoustic voice differences may be mainly linked to behavior, which should be considered in future works regarding physiologic voice development., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
34. Clinical relevance of speaking voice intensity effects on acoustic jitter and shimmer in children between 5;0 and 9;11 years.
- Author
-
Brockmann-Bauser M, Beyer D, and Bohlender JE
- Subjects
- Child, Child, Preschool, Cohort Studies, Cross-Sectional Studies, Female, Humans, Male, Phonation, Speech Acoustics, Voice Disorders diagnosis, Voice Quality
- Abstract
Background: Current voice assessment recommendations for dysphonic children comprise instrumental acoustic measurements of the perturbation parameters jitter and shimmer. In healthy adults and children changes in speaking voice sound pressure level (voice SPL) have significant confounding effects on both parameters. In adults these effects were considerably reduced in phonations with controlled voice SPL >80dBA (10cm distance). However, it is unclear if these findings apply to children and if children are able to control for their own voice intensity., Objective: This cross-sectional single cohort study investigates voice SPL effects on jitter and shimmer in children between 5;0 and 9;11 years phonating at individually "medium" (modeling "comfortable" loudness of the usual clinical protocol), "soft" and "loud" voice and a prescribed intensity level of ">80dBA" (10cm distance, with visual control). Further both their ability to phonate at a prescribed voice intensity level and the effect on SPL related confounding effects were studied., Subjects and Methods: A total of 68 healthy children (39 f/29m) aged 5;0 to 9;11 years were included. All phonated the vowel/a/for 5s, three times at four defined voice intensity levels (soft/medium/loud/>80dBA) each. Jitter (%), shimmer (%) and voice SPL (dBA) were determined using PRAAT. Voice intensity level effects were assessed by descriptive statistics, Analysis of Variance (ANOVA) and Linear Mixed Models (LMM)., Results: There were significant differences for jitter and shimmer between all voice tasks (p<.01). Jitter and shimmer were lowest and showed the smallest spread in controlled phonations ">80dBA". 19 children below 7;0 years could not perform the voice tasks and were excluded from the study., Conclusions: This practical study demonstrated a significant effect of voice loudness and task on jitter and shimmer in children. Since the observed confounding effects were large compared to treatment effects, jitter and shimmer may not be meaningful without adequate control of voice SPL. In phonations at ">80dBA" (10cm distance) voice SPL related effects were considerably reduced. However, this assessment protocol was suitable only for children above 7;0 years. Application of this task to future studies of dysphonic children may yield clinically valuable information., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
35. Secondary voice prosthesis insertion in patients without direct access to the upper esophagus.
- Author
-
Meerwein C, Laske R, Castiglioni K, Bohlender JE, and Huber GF
- Subjects
- Aged, Equipment Design, Esophagus, Humans, Male, Larynx, Artificial, Prosthesis Implantation instrumentation, Prosthesis Implantation methods
- Published
- 2014
- Full Text
- View/download PDF
36. Feeding dystonia in McLeod syndrome.
- Author
-
Gantenbein AR, Damon-Perrière N, Bohlender JE, Chauveau M, Latxague C, Miranda M, Jung HH, and Tison F
- Subjects
- Aged, Humans, Male, Middle Aged, Nervous System Diseases genetics, Neuroacanthocytosis genetics, Dystonia etiology, Feeding Behavior physiology, Nervous System Diseases complications, Neuroacanthocytosis complications
- Abstract
Background: The X-linked McLeod syndrome belongs to the group of neuroacanthocytosis syndromes and has a Huntington-disease-like phenotype with a choreatic movement disorder, cognitive alterations, and psychiatric symptoms. Another neuroacanthocytosis syndrome, the autosomal recessive chorea-acanthocytosis, has a similar presentation, but distinct clinical features, believed to be characteristic, such as tongue protrusion dystonia, feeding dystonia, and rubber-man-like appearance., Methods: This work comprised a case series of 3 patients with McLeod syndrome., Results: The 3 patients with McLeod syndrome developed severe feeding dystonia and tongue protrusion as well as rubber-man-like appearance in 1 patient during the course of the disease., Conclusion: These observations indicate that there is an extended phenotypic overlap between McLeod syndrome and chorea-acanthocytosis., (Copyright © 2011 Movement Disorder Society.)
- Published
- 2011
- Full Text
- View/download PDF
37. [The use of melatonin as an alternative to sedation in children undergoing brainstem audiometry].
- Author
-
Schmidt CM, Bohlender JE, Deuster D, Knief A, Matulat P, and Dinnesen AG
- Subjects
- Adolescent, Adult, Awareness drug effects, Awareness physiology, Brain Stem drug effects, Child, Child, Preschool, Dose-Response Relationship, Drug, Evoked Potentials, Auditory, Brain Stem drug effects, Evoked Potentials, Auditory, Brain Stem physiology, Female, Humans, Male, Premedication, Reaction Time drug effects, Reaction Time physiology, Sleep drug effects, Sleep physiology, Audiometry, Evoked Response methods, Brain Stem physiopathology, Hypnotics and Sedatives administration & dosage, Melatonin administration & dosage
- Abstract
Background: Though one of the most important investigations in paediatric audiology, brainstem evoked response audiometry (BERA) often necessitates sedation or general anaesthetics, especially in newborn and infants. In paediatric neurology, melatonin has been successfully used for some years to induce sleep prior to EEG investigations. Melatonin as a hormone regulating the circadian rhythm induces natural sleep without the risks of sedation. Side effects are not known., Methods: Click-induced BERA was first performed in 10 adults with normal hearing with and without previous melatonin administration, and click thresholds and latencies of evoked potentials were compared. 50 children then underwent BERA in melatonin-induced sleep., Results: Click thresholds in adults were mostly identical (r = 0,88), while the mean latencies of evoked potentials seemed to be minimally prolonged (r from 0,82 to 0,95). Click-induced BERA was successful in 45 of the 50 children, and notched-noise BERA in at least 2 frequencies in 38 of 43 children., Conclusions: Offering a high success rate with no side effects, melatonin-induced sleep seems to be a good alternative to sedation. This method is widely accepted by parents and permits earlier diagnosis of hearing impairment in the routine clinical setting.
- Published
- 2004
- Full Text
- View/download PDF
38. Thin section arrays for I-FISH analysis of chromosome-specific imbalances in squamous cell carcinomas of the head and neck.
- Author
-
Ott CE, Skroch E, Steinhart H, Verdorfer I, Pahl S, Iro H, Gebhart E, and Bohlender JE
- Subjects
- Aged, Cell Nucleus metabolism, Chromosome Aberrations, Female, Humans, Male, Middle Aged, Carcinoma, Squamous Cell genetics, Chromosomes ultrastructure, Head and Neck Neoplasms genetics, In Situ Hybridization, Fluorescence methods
- Abstract
Thin section arrays of 20 head and neck squamous cell carcinomas were studied by I-FISH for gains (including amplification) and losses of specific genomic segments. These arrays allow the examination not only of a number of tumor sections but also of the surrounding margins and of inconspicuous control tissue in one experiment. All tumor sections examined significantly differed from the inconspicuous control tissues by containing more or less extensive cell populations with aberrant signal constitutions. In no case, however, did the aberrant population constitute the whole area of the section. Gains of signals were strikingly more frequent than were losses. All tumors showed significant gains of the segments examined, the highest differences between tumor and control sections were found for the segments 9q34 and 8q24, followed by 5p15.3 and 11q13. Amplifications were most frequently found of 11q13: 8 of the 20 tumors showed amplifications in more than 20% of the nuclei, while no nucleus with more than four signals was found in any of the control tissues (control: 0%). Amplifications of the target sequences on chromosomes 8 (14 tumors) and 9 (8 tumors) were observed in low but significant percentages of nuclei, no significant cell population was detected with an amplification of 5p15.3. Fourteen tumors exhibited a significant loss of 13q14, and only 8 tumors a significant loss at any other site. In the tumor margin sections, in most cases, the margins apparently were also affected by the one or the other of the genomic changes of the pertinent primary tumor. Nevertheless, there were, in some cases, also large differences depending on the way of analysis, but also on the specific signal constitution considered. Tumor stages T3 and T4 tended to have higher frequency of nuclei with gains of 5p15.3, 8q24, and 11q13 as compared to T2 tumors and less gains of 9q34 and loss of 13q14. With the exception of 8q24 and 13q14 alterations there was also a trend to higher percentages of aberrant nuclei in the margin of T3-4 tumors vs. T2 tumors.
- Published
- 2002
- Full Text
- View/download PDF
39. Genetic imbalances in preinvasive tissue of hypopharynx provide evidence for cytogenetic heterogeneity.
- Author
-
Steinhart H, Bohlender JE, Constantinidis J, Urbschat S, Fischer U, Iro H, Pahl S, and Meese E
- Subjects
- Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 12, Chromosomes, Human, Pair 3, Chromosomes, Human, Pair 6, DNA, Neoplasm isolation & purification, Head and Neck Neoplasms genetics, Head and Neck Neoplasms pathology, Humans, Neoplasm Invasiveness genetics, Carcinoma, Squamous Cell genetics, Carcinoma, Squamous Cell pathology, Chromosome Pairing, Gene Amplification, Hypopharyngeal Neoplasms genetics, Hypopharyngeal Neoplasms pathology
- Abstract
Multiple chromosomal aberrations have been reported in head and neck squamous cell carcinoma (HNSCC). But less information is available on specific patterns of chromosomal amplifications which distinguish different areas of head and neck tumors. To elucidate genetic mechanisms causing the aggressive growth and high proliferation of hypopharyngeal squamous cell carcinoma (SCC), we performed reverse chromosome painting (RCP) on a total of eight hypopharyngeal SCC including invasive carcinoma and preinvasive tissue. Five hypopharyngeal invasive carcinomas showed amplifications on chromosome 3q. Furthermore, we detected gains on chromosomes 11q and 6p. Compared to the histologically classified preinvasive tissues, we found amplified alterations on chromosome 6p, 11q and 12q, but none of them showed gains on chromosome 3q. This observed heterogeneity in hypopharyngeal SCC might reflect a specific role of chromosome 3q as a late event in the highly invasive capacity of these SCC.
- Published
- 2001
- Full Text
- View/download PDF
40. Clinical relevance of distortion product emissions by means of receiver operating characteristic (ROC) analysis.
- Author
-
Steinhart HU, Bohlender JE, Benttzien S, and Hoppe U
- Subjects
- Adult, Auditory Threshold physiology, Female, Hair Cells, Auditory, Outer physiopathology, Hearing Loss, Sensorineural physiopathology, Humans, Male, Middle Aged, Reproducibility of Results, Otoacoustic Emissions, Spontaneous physiology, ROC Curve
- Abstract
The clinical use of distortion product otoacoustic emissions (DPOAE) stems from the observation that the outer hair cells are the most vulnerable part of the cochlea, and damage to these cells is associated with hearing loss and loss of DPOAE. The purpose of this study is to evaluate the applicability of DPOAE in predicting hearing thresholds under clinical conditions. DPOAE measurements (L1 = L2 = 70 dB SPL. f2/f1 = 1.20) of 219 hearing-impaired and normal hearing ears were analyzed. Recordings were acquired for DPOAE at 2 f1-f2 varying from 635 to 4052 Hz. The detectability of DPOAE in hearing-impaired subjects exhibited a strong hearing threshold dependence. Receiver operating characteristic (ROC) analysis yielded the highest sensitivity and specificity for threshold levels of about 30 dB at low frequencies and for threshold levels of about 60 dB at high frequencies. In addition, the separability of groups with different hearing status was more reliable at high frequencies as compared to low frequencies. The DPOAE provide an objective assessment of cochlear function. However, prognosis of hearing thresholds on the basis of DPOAE measurements depends strongly on the test frequency and is associated with large errors. Hence, the clinical use of DPOAE in predicting hearing thresholds is limited.
- Published
- 2001
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.