9 results on '"Bohleber, Laura M."'
Search Results
2. Differential Alterations in Resting State Functional Connectivity Associated with Depressive Symptoms and Early Life Adversity
- Author
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Fadel, Eleonora; https://orcid.org/0000-0002-7450-7854, Boeker, Heinz; https://orcid.org/0000-0001-8996-919X, Gaertner, Matti, Richter, Andre; https://orcid.org/0000-0002-5386-0165, Kleim, Birgit; https://orcid.org/0000-0001-9114-2917, Seifritz, Erich, Grimm, Simone, Wade-Bohleber, Laura M; https://orcid.org/0000-0001-8219-8943, Fadel, Eleonora; https://orcid.org/0000-0002-7450-7854, Boeker, Heinz; https://orcid.org/0000-0001-8996-919X, Gaertner, Matti, Richter, Andre; https://orcid.org/0000-0002-5386-0165, Kleim, Birgit; https://orcid.org/0000-0001-9114-2917, Seifritz, Erich, Grimm, Simone, and Wade-Bohleber, Laura M; https://orcid.org/0000-0001-8219-8943
- Abstract
Depression and early life adversity (ELA) are associated with aberrant resting state functional connectivity (FC) of the default mode (DMN), salience (SN), and central executive networks (CEN). However, the specific and differential associations of depression and ELA with FC of these networks remain unclear. Applying a dimensional approach, here we analyzed associations of FC between major nodes of the DMN, SN, and CEN with severity of depressive symptoms and ELA defined as childhood abuse and neglect in a sample of 83 healthy and depressed subjects. Depressive symptoms were linked to increased FC within the SN and decreased FC of the SN with the DMN and CEN. Childhood abuse was associated with increased FC within the SN, whereas childhood neglect was associated with decreased FC within the SN and increased FC between the SN and the DMN. Our study thus provides evidence for differential associations of depressive symptoms and ELA with resting state FC and contributes to a clarification of previously contradictory findings. Specific FC abnormalities may underlie specific cognitive and emotional impairments. Future research should link specific clinical symptoms resulting from ELA to FC patterns thereby characterizing depression subtypes with specific neurobiological signatures.
- Published
- 2021
3. One look is worth a thousand words : new picture stimuli of interpersonal situations
- Author
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Fuchs, Simon, Bohleber, Laura M, Ernst, Jutta, Soguel-Dit-Piquard, Jasmine, Boeker, Heinz, Richter, Andre, Fuchs, Simon, Bohleber, Laura M, Ernst, Jutta, Soguel-Dit-Piquard, Jasmine, Boeker, Heinz, and Richter, Andre
- Abstract
This paper introduces a picture system that can be used in functional imaging experiments exploring interpersonal relations. This is important for psychotherapy research to understand the neural basis of psychological treatment effects. Pictures have many advantages for the design of functional imaging experiments, but no picture system illustrating interpersonal behavior patterns is, to date, available. We therefore developed, on the basis of a validated card-sorting test, the Interpersonal Relations Picture System. In summary, 43 pictures with 2 or more stick figures in different social situations and 9 control pictures were composed. To test the relation between each picture and the appropriate description, two successive online surveys, including 1058 and 675 individuals respectively, were conducted. Using two question types, the grade expressiveness of each picture was assessed. In total, 24 pictures and 6 control pictures met our criteria for sufficient strength and consistency with the appropriate description. Both measures are correlated with each other in all pictures illustrating interpersonal behavior, but not in the control pictures. Relations to other stimulus types and the applicability of the new picture system in functional neuroimaging methods are discussed. It is concluded that the new system will be helpful in studying the profound effect of relational change in psychotherapy.
- Published
- 2020
4. Depression is associated with hyperconnectivity of an introspective socio-affective network during the recall of formative relationship episodes
- Author
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Wade-Bohleber, Laura M; https://orcid.org/0000-0001-8219-8943, Boeker, H, Grimm, S, Gärtner, M, Ernst, J, Recher, D A, Buergi, N, Seifritz, E, Richter, A, Wade-Bohleber, Laura M; https://orcid.org/0000-0001-8219-8943, Boeker, H, Grimm, S, Gärtner, M, Ernst, J, Recher, D A, Buergi, N, Seifritz, E, and Richter, A
- Abstract
BACKGROUND: Depression and the experience of early adversity are associated with impairments in interpersonal and social cognitive functioning. The neural mechanisms involved in these impairments remain insufficiently understood. METHODS: In a sample of 48 depressed and 50 healthy participants, we explored seed-to-voxel functional connectivity (FC) during the recall of formative relationship episodes using functional magnetic resonance imaging. RESULTS: While depressive symptoms were associated with increased FC of brain regions that form an introspective socio-affective network, such as the precuneus, bilateral anterior insula, dorsal anterior cingulate cortex, left amygdala, and medial prefrontal cortex, early adversity linked to decreased FC of brain regions mediating emotion processing such as the bilateral anterior insula and increased FC of the bilateral parahippocampal gyrus. LIMITATIONS: We report both results that are corrected for the number of seeds tested in FC analyses using strict Bonferroni adjustments and unadjusted results as part of an exploratory analysis. DISCUSSION: Our findings suggest that depression and early adversity are associated with differential FC patterns in the brain during the recall of formative relationship episodes. Hyperconnectivity of an introspective socio-affective network associated with depressive symptoms may link to enhanced self-focus and emotional reactivity. Patterns of neural activation associated with early adversity may underpin numbed affective states or enhanced affective memory regulation. Overall, these findings inform about the neural underpinnings of a reflective ability that is predictive of the adaptation to depression and to early adversity and relevant for psychotherapy outcomes.
- Published
- 2020
5. Associations of Social and Psychological Resources with Different Facets of Chronic Stress: A Study with Employed and Unemployed Adolescents
- Author
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Wade-Bohleber, Laura M; https://orcid.org/0000-0001-8219-8943, Duss, Carmen, Crameri, Aureliano, von Wyl, Agnes, Wade-Bohleber, Laura M; https://orcid.org/0000-0001-8219-8943, Duss, Carmen, Crameri, Aureliano, and von Wyl, Agnes
- Abstract
Adolescents navigate many psychosocial changes. A critical transition in adolescence is the one from school to work life. Both taking the first steps in work life and the failure to achieve this transition and being unemployed can engender elevated levels of stress during adolescence. Stress, especially when experienced chronically, is an important risk factor for mental health problems. Social and psychological resources may mitigate the experience of chronic stress. This study explored associations of social and family support, self-esteem, and self-efficacy with different dimensions of chronic stress in a sample of 1405 employed and unemployed adolescents (M(age) = 17.84, SD = 1.63, range: 14.05–26.12) in Switzerland. Unemployed adolescents showed higher stress levels overall. Higher levels of social and psychological resources were generally linked to lower stress levels. Social support and self-esteem predicted stress levels most consistently and strongly. On several stress dimensions, the association between higher self-esteem and lower stress levels was more pronounced in employed youth whereas the association between higher social support and lower stress levels was stronger in unemployed youth. Our findings provide insights on the differential associations of social and psychological resources with various facets of chronic stress in the context of employment and unemployment during adolescence.
- Published
- 2020
6. Associations of Social and Psychological Resources with Different Facets of Chronic Stress: A Study with Employed and Unemployed Adolescents
- Author
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Wade-Bohleber, Laura M., primary, Duss, Carmen, additional, Crameri, Aureliano, additional, and von Wyl, Agnes, additional
- Published
- 2020
- Full Text
- View/download PDF
7. One look is worth a thousand words: New picture stimuli of interpersonal situations
- Author
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Fuchs, Simon, primary, Bohleber, Laura M., additional, Ernst, Jutta, additional, Soguel-dit-Piquard, Jasmine, additional, Boeker, Heinz, additional, and Richter, Andre, additional
- Published
- 2017
- Full Text
- View/download PDF
8. One look is worth a thousand words: New picture stimuli of interpersonal situations.
- Author
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Fuchs, Simon, Bohleber, Laura M., Ernst, Jutta, Soguel-dit-Piquard, Jasmine, Boeker, Heinz, and Richter, Andre
- Subjects
- *
INTERPERSONAL relations , *FUNCTIONAL magnetic resonance imaging , *COGNITIVE neuroscience , *BRAIN imaging , *SOCIAL psychology - Abstract
This paper introduces a picture system that can be used in functional imaging experiments exploring interpersonal relations. This is important for psychotherapy research to understand the neural basis of psychological treatment effects. Pictures have many advantages for the design of functional imaging experiments, but no picture system illustrating interpersonal behavior patterns is, to date, available. We therefore developed, on the basis of a validated card-sorting test, the Interpersonal Relations Picture System. In summary, 43 pictures with 2 or more stick figures in different social situations and 9 control pictures were composed. To test the relation between each picture and the appropriate description, two successive online surveys, including 1058 and 675 individuals respectively, were conducted. Using two question types, the grade expressiveness of each picture was assessed. In total, 24 pictures and 6 control pictures met our criteria for sufficient strength and consistency with the appropriate description. Both measures are correlated with each other in all pictures illustrating interpersonal behavior, but not in the control pictures. Relations to other stimulus types and the applicability of the new picture system in functional neuroimaging methods are discussed. It is concluded that the new system will be helpful in studying the profound effect of relational change in psychotherapy. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
9. Associations of Social and Psychological Resources with Different Facets of Chronic Stress: A Study with Employed and Unemployed Adolescents
- Author
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Carmen Duss, Agnes von Wyl, Aureliano Crameri, Laura Maria Wade-Bohleber, University of Zurich, and Wade-Bohleber, Laura M
- Subjects
Employment ,Male ,unemployment ,Adolescent ,Health, Toxicology and Mutagenesis ,Family support ,media_common.quotation_subject ,lcsh:Medicine ,Context (language use) ,610 Medicine & health ,Article ,psychological resources ,03 medical and health sciences ,Social support ,0302 clinical medicine ,Stress (linguistics) ,2307 Health, Toxicology and Mutagenesis ,Psychological resource ,Humans ,Chronic stress ,030212 general & internal medicine ,media_common ,chronic stress ,155: Differentielle Psychologie und Entwicklungspsychologie ,Environmental and Occupational Health ,lcsh:R ,Public Health, Environmental and Occupational Health ,Social Support ,305: Soziale Gruppen ,2739 Public Health, Environmental and Occupational Health ,Mental health ,Self Concept ,social resources ,Health ,10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics ,2310 Pollution ,Unemployment ,Female ,adolescence ,Public Health ,Social resource ,Psychology ,Psychosocial ,030217 neurology & neurosurgery ,Stress, Psychological ,Switzerland ,Clinical psychology - Abstract
Adolescents navigate many psychosocial changes. A critical transition in adolescence is the one from school to work life. Both taking the first steps in work life and the failure to achieve this transition and being unemployed can engender elevated levels of stress during adolescence. Stress, especially when experienced chronically, is an important risk factor for mental health problems. Social and psychological resources may mitigate the experience of chronic stress. This study explored associations of social and family support, self-esteem, and self-efficacy with different dimensions of chronic stress in a sample of 1405 employed and unemployed adolescents (M(age) = 17.84, SD = 1.63, range: 14.05&ndash, 26.12) in Switzerland. Unemployed adolescents showed higher stress levels overall. Higher levels of social and psychological resources were generally linked to lower stress levels. Social support and self-esteem predicted stress levels most consistently and strongly. On several stress dimensions, the association between higher self-esteem and lower stress levels was more pronounced in employed youth whereas the association between higher social support and lower stress levels was stronger in unemployed youth. Our findings provide insights on the differential associations of social and psychological resources with various facets of chronic stress in the context of employment and unemployment during adolescence.
- Published
- 2020
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