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1. Efficacy of probiotic treatment as post-exposure prophylaxis for COVID-19: A double-blind, Placebo-Controlled Randomized trial

Author

Wischmeyer, Paul E., Tang, Helen, Ren, Yi, Bohannon, Lauren, Jiang, Danting, Bergens, Matthew, Ramirez, Zeni E., Andermann, Tessa M., Messina, Julia A., Sung, Julia A., Jensen, David, Jung, Sin-Ho, Artica, Alexandra, Britt, Anne, Bush, Amy, Johnson, Ernaya, Lew, Meagan V., Winthrop, Hilary, Pamanes, Claudia, Racioppi, Alessandro, Zhao, Aaron T., Wan, Zihan, Surana, Neeraj K., and Sung, Anthony D.

Published
2024
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2. High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients

Author

Nguyen, Chi L., Markey, Kate A., Miltiadous, Oriana, Dai, Anqi, Waters, Nicholas, Sadeghi, Keimya, Fei, Teng, Shouval, Roni, Taylor, Bradford P., Liao, Chen, Slingerland, John B., Slingerland, Ann E., Clurman, Annelie G., Maloy, Molly A., Bohannon, Lauren, Giardina, Paul A., Brereton, Daniel G., Armijo, Gabriel K., Fontana, Emily, Gradissimo, Ana, Gyurkocza, Boglarka, Sung, Anthony D., Chao, Nelson J., Devlin, Sean M., Taur, Ying, Giralt, Sergio A., Perales, Miguel-Angel, Xavier, Joao B., Pamer, Eric G., Peled, Jonathan U., Gomes, Antonio L.C., and van den Brink, Marcel R.M.

Published
2023
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3. Preconditioning Frailty Phenotype Influences Survival and Relapse for Older Allogeneic Transplantation Recipients

Author

Sung, Anthony D., Koll, Thuy, Gier, Shannon H., Racioppi, Alessandro, White, Griffin, Lew, Meagan, Free, Marcia, Agarwal, Priyal, Bohannon, Lauren M., Johnson, Ernaya J., Selvan, Bharathi, Babushok, Daria V., Frey, Noelle V., Gill, Saar I., Hexner, Elizabeth O., Martin, MaryEllen, Perl, Alexander E., Pratz, Keith W., Luger, Selina M., Chao, Nelson J., Fisher, Alfred L., Stadtmauer, Edward A., Porter, David L., Loren, Alison W., Bhatt, Vijaya R., Gimotty, Phyllis A., and McCurdy, Shannon R.

Published
2024
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5. Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study

Author

Khan, Niloufer, Lindner, Sarah, Gomes, Antonio L.C., Devlin, Sean M., Shah, Gunjan L., Sung, Anthony D., Sauter, Craig S., Landau, Heather J., Dahi, Parastoo B., Perales, Miguel-Angel, Chung, David J., Lesokhin, Alexander M., Dai, Anqi, Clurman, Annelie, Slingerland, John B., Slingerland, Ann E., Brereton, Daniel G., Giardina, Paul A., Maloy, Molly, Armijo, Gabriel K., Rondon-Clavo, Carlos, Fontana, Emily, Bohannon, Lauren, Ramalingam, Sendhilnathan, Bush, Amy T., Lew, Meagan V., Messina, Julia A., Littmann, Eric, Taur, Ying, Jenq, Robert R., Chao, Nelson J., Giralt, Sergio, Markey, Kate A., Pamer, Eric G., van den Brink, Marcel R.M., and Peled, Jonathan U.

Published
2021
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6. Clinical and Neuroimaging Correlates of Post-Transplant Delirium

Author

Smith, Patrick, Thompson, Jillian C., Perea, Elena, Wasserman, Brian, Bohannon, Lauren, Racioppi, Alessandro, Choi, Taewoong, Gasparetto, Cristina, Horwitz, Mitchell E., Long, Gwynn, Lopez, Richard, Rizzieri, David A., Sarantopoulos, Stefanie, Sullivan, Keith M., Chao, Nelson J., and Sung, Anthony D.

Published
2020
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8. Financial Toxicity and Quality of Life in Patients Undergoing Stem-Cell Transplant Evaluation: A Single-Center Analysis

Author

Hussaini, S.M. Qasim, primary, Ren, Yi, additional, Racioppi, Alessandro, additional, Lew, Meagan V., additional, Bohannon, Lauren, additional, Johnson, Ernaya, additional, Li, Yan, additional, Thompson, Jillian C., additional, Henshall, Bethany, additional, Darby, Maurisa, additional, Choi, Taewoong, additional, Lopez, Richard D., additional, Sarantopoulos, Stefanie, additional, Gasparetto, Cristina, additional, Long, Gwynn D., additional, Horwitz, Mitchell E., additional, Chao, Nelson J., additional, Zafar, S. Yousuf, additional, and Sung, Anthony D., additional

Published
2023
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9. The gut microbiota is associated with immune cell dynamics in humans

Author

Schluter, Jonas, Peled, Jonathan U., Taylor, Bradford P., Markey, Kate A., Smith, Melody, Taur, Ying, Niehus, Rene, Staffas, Anna, Dai, Anqi, Fontana, Emily, Amoretti, Luigi A., Wright, Roberta J., Morjaria, Sejal, Fenelus, Maly, Pessin, Melissa S., Chao, Nelson J., Lew, Meagan, Bohannon, Lauren, Bush, Amy, Sung, Anthony D., Hohl, Tobias M., Perales, Miguel-Angel, van den Brink, Marcel R. M., and Xavier, Joao B.

Published
2020
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10. Financial Toxicity and Quality of Life in Patients Undergoing Stem-Cell Transplant Evaluation: A Single-Center Analysis.

Author

Hussaini, S.M. Qasim, Ren, Yi, Racioppi, Alessandro, Lew, Meagan V., Bohannon, Lauren, Johnson, Ernaya, Li, Yan, Thompson, Jillian C., Henshall, Bethany, Darby, Maurisa, Choi, Taewoong, Lopez, Richard D., Sarantopoulos, Stefanie, Gasparetto, Cristina, Long, Gwynn D., Horwitz, Mitchell E., Chao, Nelson J., Zafar, S. Yousuf, and Sung, Anthony D.

Subjects
HEMATOPOIETIC stem cell transplantation, HEALTH impact assessment, ACADEMIC medical centers, RESEARCH funding, QUESTIONNAIRES, LOGISTIC regression analysis, PILOT projects, MULTIVARIATE analysis, DESCRIPTIVE statistics, CHI-squared test, FINANCIAL stress, LONGITUDINAL method, KAPLAN-Meier estimator, QUALITY of life, ANALYSIS of variance, COMPARATIVE studies, DATA analysis software, OVERALL survival
Abstract

PURPOSE: We investigated the prevalence of financial toxicity in a population undergoing hematopoietic cell transplantation (HCT) evaluation and measured its impact on post-transplant clinical and health-related quality-of-life outcomes. MATERIALS AND METHODS: This was a prospective study in patients undergoing evaluation for allogeneic HCT between January 1, 2018, and September 23, 2020, at a large academic medical center. Financial health was measured via a baseline survey and the comprehensive score for financial toxicity-functional assessment of chronic illness therapy (COST-FACIT) survey. The cohort was divided into three groups: none (grade 0), mild (grade 1), and moderate-high financial toxicity (grades 2-3). Health-related quality of life outcomes were measured at multiple time points. Multivariate logistic regression analysis evaluated factors associated with financial toxicity. Kaplan-Meier curves and log-rank tests was used to evaluate overall survival (OS) and nonrelapse survival. RESULTS: Of 245 patients evaluated for transplant, 176 (71.8%) completed both questionnaires (median age was 57 years, 63.1% were male, 72.2% were White, and 39.2% had myelodysplastic syndrome, 38.1% leukemia, and 13.6% lymphoma). At initial evaluation, 83 (47.2%) patients reported no financial toxicity, 51 (29.0%) with mild, and 42 (23.9%) with moderate-high financial toxicity. Patients with financial toxicity reported significant cost-cutting behaviors, including reduced spending on food or clothing, using their savings, or not filling a prescription because of costs (P <.0001). Quality of life was lower in patients with moderate-high financial toxicity at 6 months (P =.0007) and 1 year (P =.0075) after transplant. Older age (>62; odds ratio [OR], 0.33 [95% CI, 0.13 to 0.79]; P =.04) and income ≥$60,000 in US dollars (USD) (OR, 0.17 [95% CI, 0.08 to 0.38]; P <.0001) were associated with lower odds of financial toxicity. No association was noted between financial toxicity and selection for transplant, OS, or nonrelapse mortality. CONCLUSION: Financial toxicity was highly correlated with patient-reported changes in compensatory behavior, with notable impact on patient quality of life after transplant. Prospective cohort study demonstrates a major impact of #FinancialToxicity in driving cost-cutting behaviors and worse quality of life in patients undergoing bone marrow transplant [ABSTRACT FROM AUTHOR]

Published
2024
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11. Geriatric Assessment Reveals Actionable Impairments in Hematopoietic Stem Cell Transplantation Candidates Age 18 to 80 Years

Author

Lew, Meagan V., Ren, Yi, Lowder, Yen P., Siamakpour-Reihani, Sharareh, Ramalingam, Sendhilnathan, Romero, Kristi M., Thompson, Jillian C., Bohannon, Lauren M., McIntyre, Jackie, Tang, Helen, Van Opstal, Jolien, Johnson, Ernaya, Cohen, Harvey Jay, Bartlett, David B., Pastva, Amy M., Morey, Miriam, Hall, Katherine S., Smith, Patrick, Peters, Katherine B., Somers, Tamara J., Kelleher, Sarah, Smith, Sophia K., Wischmeyer, Paul E., Lin, Pao-Hwa, Wood, William A., Thorpe, Glynnis, Minor, Kerry, Wiggins, Kristi, Hennig, Therese, Helms, Tanya, Welch, Renee, Matthews, Brittany, Liu, JoAnn, Burleson, Jill, Aberant, Thomas, Engemann, Ashley K., Henshall, Bethany, Darby, Maurisa, Proch, Christina, Dellascio, Michelle, Pittman, Alyssa, Suminguit, Jacob, Choi, Taewoong, Gasparetto, Cristina, Long, Gwynn D., Lopez, Richard D., Sarantopoulos, Stefanie, Horwitz, Mitchell E., Chao, Nelson J., and Sung, Anthony D.

Published
2022
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12. Home-Based Hematopoietic Cell Transplantation in the United States

Author

Sung, Anthony D., Giri, Vinay K., Tang, Helen, Nichols, Krista Rowe, Lew, Meagan V., Bohannon, Lauren, Ren, Yi, Jung, Sin-Ho, Dalton, Tara, Bush, Amy, Van Opstal, Jolien, Artica, Alexandra, Messina, Julia, Shelby, Rebecca, Frith, Jennifer, Lassiter, Martha, Burleson, Jill, Leonard, Kari, Potter, Ashley S., Choi, Taewoong, Gasparetto, Cristina J., Horwitz, Mitchell E., Long, Gwynn D., Lopez, Richard D., Sarantopoulos, Stefanie, and Chao, Nelson J.

Published
2022
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14. Decreased Mortality in 1-Year Survivors of Umbilical Cord Blood Transplant vs. Matched Related or Matched Unrelated Donor Transplant in Patients with Hematologic Malignancies

Author

Bohannon, Lauren, Tang, Helen, Page, Kristin, Ren, Yi, Jung, Sin-Ho, Artica, Alexandra, Britt, Anne, Islam, Prioty, Siamakpour-Reihani, Sharareh, Giri, Vinay, Lew, Meagan, Kelly, Matthew, Choi, Taewoong, Gasparetto, Cristina, Long, Gwynn, Lopez, Richard, Rizzieri, David, Sarantopoulos, Stefanie, Chao, Nelson, Horwitz, Mitchell, and Sung, Anthony

Published
2021
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15. Chlorhexidine Gluconate Bathing Reduces the Incidence of Bloodstream Infections in Adults Undergoing Inpatient Hematopoietic Cell Transplantation

Author

Giri, Vinay K., Kegerreis, Kristin G., Ren, Yi, Bohannon, Lauren M., Lobaugh-Jin, Erica, Messina, Julia A., Matthews, Anita, Mowery, Yvonne M., Sito, Elizabeth, Lassiter, Martha, Saullo, Jennifer L., Jung, Sin-Ho, Ma, Li, Greenberg, Morris, Andermann, Tessa M., van den Brink, Marcel R.M., Peled, Jonathan U., Gomes, Antonio L.C., Choi, Taewoong, Gasparetto, Cristina J., Horwitz, Mitchell E., Long, Gwynn D., Lopez, Richard D., Rizzieri, David A., Sarantopoulos, Stefanie, Chao, Nelson J., Allen, Deborah H., and Sung, Anthony D.

Published
2021
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16. Assessing the Feasibility of a Novel mHealth App in Hematopoietic Stem Cell Transplant Patients

Author

Racioppi, Alessandro, Dalton, Tara, Ramalingam, Sendhilnathan, Romero, Kristi, Ren, Yi, Bohannon, Lauren, Arellano, Consuelo, Jonassaint, Jude, Miller, Hilary, Barak, Ian, Fish, Laura J., Choi, Taewoong, Gasparetto, Cristina, Long, Gwynn D., Lopez, Richard D., Rizzieri, David A., Sarantopoulos, Stefanie, Horwitz, Mitchell E., Chao, Nelson J., Shah, Nirmish R., and Sung, Anthony D.

Published
2021
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17. A pilot study to assess the feasibility of a remotely monitored high-intensity interval training program prior to allogeneic hematopoietic stem cell transplantation.

Author

Artese, Ashley L., Winthrop, Hilary M., Bohannon, Lauren, Lew, Meagan V., Johnson, Ernaya, MacDonald, Grace, Ren, Yi, Pastva, Amy M., Hall, Katherine S., Wischmeyer, Paul E., Macleod, David, Molinger, Jeroen, Barth, Stratton, Jung, Sin-Ho, Cohen, Harvey Jay, Bartlett, David B., and Sung, Anthony D.

Subjects
HEMATOPOIETIC stem cell transplantation, HIGH-intensity interval training, PHYSICAL fitness, PHYSICAL mobility, CARDIOPULMONARY fitness, PILOT projects
Abstract

Introduction: Although allogeneic hematopoietic stem cell transplantation (HCT) can be a curative therapy for hematologic disorders, it is associated with treatment-related complications and losses in cardiorespiratory fitness and physical function. High-intensity interval training (HIIT) may be a practical way to rapidly improve cardiorespiratory fitness and physical function in the weeks prior to HCT. The primary aim of this study was to assess the feasibility of implementing a pre-HCT home-based HIIT intervention. The secondary aim was to evaluate pre to post changes in cardiorespiratory fitness and physical function following the intervention. Methods: This was a single-arm pilot study with patients who were scheduled to undergo allogeneic HCT within six months. Patients were instructed to complete three 30-minute home-based HIIT sessions/week between the time of study enrollment and sign-off for HCT. Sessions consisted of a 5-minute warm-up, 10 high and low intervals performed for one minute each, and a 5-minute cool-down. Prescribed target heart rates (HR) for the high- and low-intensity intervals were 80–90% and 50–60% of HR reserve, respectively. Heart rates during HIIT were captured via an Apple Watch and were remotely monitored. Feasibility was assessed via retention, session adherence, and adherence to prescribed interval number and intensities. Paired t-tests were used to compare changes in fitness (VO2peak) and physical function [Short Physical Performance Battery (SPPB), 30-second sit to stand, and six-minute walk test (6MWT)] between baseline and sign-off. Pearson correlations were used to determine the relationship between intervention length and changes in cardiorespiratory fitness or functional measures. Results: Thirteen patients (58.8±11.6 years) participated in the study, and nine (69.2%) recorded their training sessions throughout the study. Median session adherence for those nine participants was 100% (IQR: 87–107). Adherence to intervals was 92% and participants met or exceeded prescribed high-intensity HR on 68.8±34.8% of intervals. VO2peak improved from baseline to sign-off (14.6±3.1 mL/kg/min to 17.9±3.3 mL/kg/min; p<0.001). 30-second sit to stand and SPPB chair stand scores significantly improved in adherent participants. Improvements in 30-second sit to stand (13.8±1.5 to 18.3±3.3 seconds) and 6MWT (514.4±43.2 to 564.6±19.3) exceeded minimal clinically important improvements established in other chronic disease populations, representing the minimum improvement considered meaningful to patients. Conclusions: Findings demonstrate that implementing a pre-HCT home-based remotely monitored HIIT program is feasible and may provide benefits to cardiorespiratory fitness and physical function. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Efficacy of Probiotic Treatment as Post-Exposure Prophylaxis for COVID-19: A Double-Blind, Placebo Controlled Randomized Trial

Author

Wischmeyer, Paul E., primary, Tang, Helen, additional, Ren, Yi, additional, Bohannon, Lauren, additional, Ramirez, Zeni E., additional, Andermann, Tessa M., additional, Messina, Julia A., additional, Sung, Julia A., additional, Jensen, David, additional, Jung, Sin-Ho, additional, Artica, Alexandra, additional, Britt, Anne, additional, Bush, Amy, additional, Johnson, Ernaya, additional, Lew, Meagan V., additional, Miller, Hilary M., additional, Pamanes, Claudia E., additional, Racioppi, Alessandro, additional, Zhao, Aaron T., additional, Surana, Neeraj K., additional, and Sung, Anthony D., additional

Published
2022
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19. Daily Lactobacillus Probiotic versus Placebo in COVID-19-Exposed Household Contacts (PROTECT-EHC): A Randomized Clinical Trial

Author

Wischmeyer, Paul E., primary, Tang, Helen, additional, Ren, Yi, additional, Bohannon, Lauren, additional, Ramirez, Zeni E., additional, Andermann, Tessa M., additional, Messina, Julia A., additional, Sung, Julia A., additional, Jensen, David, additional, Jung, Sin-Ho, additional, Artica, Alexandra, additional, Britt, Anne, additional, Bush, Amy, additional, Johnson, Ernaya, additional, Lew, Meagan V., additional, Miller, Hilary M., additional, Pamanes, Claudia E., additional, Racioppi, Alessandro, additional, Zhao, Aaron T., additional, Surana, Neeraj K., additional, and Sung, Anthony D., additional

Published
2022
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20. Cognitive impairment in candidates for allogeneic hematopoietic stem cell transplantation

Author

Smith, Patrick J., primary, Lew, Meagan, additional, Lowder, Yen, additional, Romero, Kristi, additional, Thompson, Jillian C., additional, Bohannon, Lauren, additional, Pittman, Alyssa, additional, Artica, Alexandra, additional, Ramalingam, Sendhilnathan, additional, Choi, Taewoong, additional, Gasparetto, Cristina, additional, Horwitz, Mitchell, additional, Long, Gwynn, additional, Lopez, Richard, additional, Rizzieri, David, additional, Sarantopoulos, Stefanie, additional, Sullivan, Keith, additional, Chao, Nelson, additional, and Sung, Anthony D., additional

Published
2021
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21. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites

Author

Guo, Hao, primary, Chou, Wei-Chun, additional, Lai, Yunjia, additional, Liang, Kaixin, additional, Tam, Jason, additional, Brickey, W. June, additional, Chen, Liang, additional, Montgomery, Nathan D., additional, Li, Xin, additional, Bohannon, Lauren M., additional, Sung, Anthony D., additional, Chao, Nelson J., additional, Peled, Jonathan U., additional, Gomes, Antonio L.C., additional, van den Brink, Marcel R.M., additional, French, Matthew J., additional, Macintyre, Andrew N., additional, Sempowski, Gregory D., additional, Tan, Xianming, additional, Sartor, R. Balfour, additional, Lu, Kun, additional, and Ting, Jenny P.Y., additional

Published
2021
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23. Fried’s Frailty Phenotype Predicts Overall Survival for Older Hematopoietic Cell Transplantation Recipients

Author

Sung, Anthony, primary, Koll, Thuy, additional, Gier, Shannon H., additional, Lew, Meagan, additional, Free, Marcia M, additional, Bohannon, Lauren, additional, Racioppi, Alessandro, additional, Babushok, Daria V., additional, Frey, Noelle V., additional, Gill, Saar I., additional, Hexner, Elizabeth O., additional, Martin, Mary Ellen, additional, Perl, Alexander E., additional, Pratz, Keith W., additional, Luger, Selina M., additional, Stadtmauer, Edward A., additional, Porter, David L., additional, Loren, Alison W., additional, Bhatt, Vijaya Raj, additional, Gimotty, Phyllis, additional, and McCurdy, Shannon R., additional

Published
2021
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24. A Phase 1 Study of the Safety and Feasibility of Improving Cardiorespiratory Fitness through a Remotely Monitored, Mobile Health Supported High Intensity Interval Training Program (REMM-HIIT)

Author

Sung, Anthony D., primary, Miller, Hilary M., additional, Romero, Kristi, additional, MacDonald, Grace, additional, Bohannon, Lauren, additional, Molinger, Jeroen, additional, Ren, Yi, additional, Bush, Amy, additional, Lew, Meagan, additional, Cohen, Harvey J, additional, Pastva, Amy, additional, Jung, Sin-Ho, additional, Shah, Nirmish R, additional, Smith, Patrick J, additional, Wischmeyer, Paul E, additional, Wood, William A, additional, Alyea, Edwin, additional, Choi, Taewoong, additional, Gasparetto, Cristina, additional, Horwitz, Mitchell E., additional, Long, Gwynn D, additional, Lopez, Richard D, additional, Rizzieri, David A, additional, Sarantopoulos, Stefanie, additional, Sullivan, Keith M, additional, Chao, Nelson J., additional, and Bartlett, David B, additional

Published
2021
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26. Female Gender Is Associated with Improved Long-Term Survival Following Allogeneic Hematopoietic Stem Cell Transplant

Author

Islam, Prioty, primary, Jin, Haesu, additional, Cao, Felicia, additional, Bohannon, Lauren M., additional, Ren, Yi, additional, Chao, Nelson J., additional, Choi, Taewoong, additional, Gasparetto, Cristina, additional, Horwitz, Mitchell E., additional, Long, Gwynn D., additional, Lopez, Richard D., additional, Rizzieri, David A, additional, Sarantopoulos, Stefanie, additional, and Sung, Anthony D., additional

Published
2020
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27. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites

Author

Guo, Hao, primary, Chou, Wei-Chun, additional, Lai, Yunjia, additional, Liang, Kaixin, additional, Tam, Jason W., additional, Brickey, W. June, additional, Chen, Liang, additional, Montgomery, Nathan D., additional, Li, Xin, additional, Bohannon, Lauren M., additional, Sung, Anthony D., additional, Chao, Nelson J., additional, Peled, Jonathan U., additional, Gomes, Antonio L. C., additional, van den Brink, Marcel R. M., additional, French, Matthew J., additional, Macintyre, Andrew N., additional, Sempowski, Gregory D., additional, Tan, Xianming, additional, Sartor, R. Balfour, additional, Lu, Kun, additional, and Ting, Jenny P. Y., additional

Published
2020
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28. The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD

Author

Markey, Kate A., primary, Schluter, Jonas, primary, Gomes, Antonio L. C., primary, Littmann, Eric R., primary, Pickard, Amanda J., primary, Taylor, Bradford P., primary, Giardina, Paul A., primary, Weber, Daniela, primary, Dai, Anqi, primary, Docampo, Melissa D., primary, Armijo, Gabriel K., primary, Slingerland, Ann E., primary, Slingerland, John B., primary, Nichols, Katherine B., primary, Brereton, Daniel G., primary, Clurman, Annelie G., primary, Ramos, Ruben J., primary, Rao, Arka, primary, Bush, Amy, primary, Bohannon, Lauren, primary, Covington, Megan, primary, Lew, Meagan V., primary, Rizzieri, David A., primary, Chao, Nelson, primary, Maloy, Molly, primary, Cho, Christina, primary, Politikos, Ioannis, primary, Giralt, Sergio, primary, Taur, Ying, primary, Pamer, Eric G., primary, Holler, Ernst, primary, Perales, Miguel-Angel, primary, Ponce, Doris M., primary, Devlin, Sean M., primary, Xavier, Joao, primary, Sung, Anthony D., primary, Peled, Jonathan U., primary, Cross, Justin R., primary, and van den Brink, Marcel R. M., primary

Published
2020
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30. Microtransplantation in older patients with AML : A pilot study of safety, efficacy and immunologic effects

Author

Sung, Anthony D., primary, Jauhari, Shekeab, additional, Siamakpour‐Reihani, Sharareh, additional, Rao, Arati V., additional, Staats, Janet, additional, Chan, Cliburn, additional, Meyer, Everett, additional, Gadi, Vijayakrishna K., additional, Nixon, Andrew B., additional, Lyu, Jing, additional, Xie, Jichun, additional, Bohannon, Lauren, additional, Li, Zhiguo, additional, Hourigan, Christopher S., additional, Dillon, Laura W., additional, Wong, Hong Yuen, additional, Shelby, Rebecca, additional, Diehl, Louis, additional, Castro, Carlos, additional, LeBlanc, Thomas, additional, Brander, Danielle, additional, Erba, Harry, additional, Galal, Ahmed, additional, Stefanovic, Alexandra, additional, Chao, Nelson, additional, and Rizzieri, David A., additional

Published
2020
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31. Clinical and Neuroimaging Predictors of Post-Transplant Delirium

Author

Smith, Patrick J., primary, Perea, Elena, additional, Thompson, Jillian, additional, Wasserman, Brian, additional, Bohannon, Lauren, additional, Choi, Taewoong, additional, Gasparetto, Cristina, additional, Horwitz, Mitchell E., additional, Long, Gwynn D., additional, Lopez, Richard, additional, Rizzieri, David A., additional, Sarantopoulos, Stefanie, additional, Chao, Nelson J., additional, and Sung, Anthony D., additional

Published
2020
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32. Phase II Trial of Pasireotide to Prevent GI Toxicity and Acute Gvhd in Allogeneic HSCT

Author

Ramalingam, Sendhilnathan, primary, Siamakpour-Reihani, Sharareh, additional, Bohannon, Lauren, additional, Ren, Yi, additional, Sibley, Alexander, additional, Nixon, Andrew, additional, Lyu, Jing, additional, Xie, Jichun, additional, Choi, Taewoong, additional, Gasparetto, Cristina, additional, Horwitz, Mitchell E., additional, Long, Gwynn D., additional, Lopez, Richard, additional, Rizzieri, David A., additional, Sarantopoulos, Stefanie, additional, Chao, Nelson J., additional, and Sung, Anthony D., additional

Published
2020
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33. Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation

Author

Peled, Jonathan U., primary, Gomes, Antonio L.C., additional, Devlin, Sean M., additional, Littmann, Eric R., additional, Taur, Ying, additional, Sung, Anthony D., additional, Weber, Daniela, additional, Hashimoto, Daigo, additional, Slingerland, Ann E., additional, Slingerland, John B., additional, Maloy, Molly, additional, Clurman, Annelie G., additional, Stein-Thoeringer, Christoph K., additional, Markey, Kate A., additional, Docampo, Melissa D., additional, Burgos da Silva, Marina, additional, Khan, Niloufer, additional, Gessner, André, additional, Messina, Julia A., additional, Romero, Kristi, additional, Lew, Meagan V., additional, Bush, Amy, additional, Bohannon, Lauren, additional, Brereton, Daniel G., additional, Fontana, Emily, additional, Amoretti, Luigi A., additional, Wright, Roberta J., additional, Armijo, Gabriel K., additional, Shono, Yusuke, additional, Sanchez-Escamilla, Míriam, additional, Castillo Flores, Nerea, additional, Alarcon Tomas, Ana, additional, Lin, Richard J., additional, Yáñez San Segundo, Lucrecia, additional, Shah, Gunjan L., additional, Cho, Christina, additional, Scordo, Michael, additional, Politikos, Ioannis, additional, Hayasaka, Kasumi, additional, Hasegawa, Yuta, additional, Gyurkocza, Boglarka, additional, Ponce, Doris M., additional, Barker, Juliet N., additional, Perales, Miguel-Angel, additional, Giralt, Sergio A., additional, Jenq, Robert R., additional, Teshima, Takanori, additional, Chao, Nelson J., additional, Holler, Ernst, additional, Xavier, Joao B., additional, Pamer, Eric G., additional, and van den Brink, Marcel R.M., additional

Published
2020
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34. The gut microbiota influences how circulating immune cells in humans change from one day to the next

Author

Schluter, Jonas, Peled, Jonathan U., Taylor, Bradford P., Smith, Melody, Markey, Kate A., Taur, Ying, Niehus, Rene, Staffas, Anna, Dai, Anqi, Fontana, Emily, Amoretti, Luigi A., Wright, Roberta J., Morjaria, Sejal, Fenelus, Maly, Pessin, Melissa S., Chao, Nelson J., Lew, Meagan, Bohannon, Lauren, Bush, Amy, Sung, Anthony D., Hohl, Tobias M., Perales, Miguel-Angel, van den Brink, Marcel R.M., and Xavier, Joao B.

Subjects
bacteria, biochemical phenomena, metabolism, and nutrition
Abstract

The gut microbiota influences the development and homeostasis of the mammalian immune system 1–3 , can alter immune cell compositions in mice 4–7 , and is associated with responses to immunotherapy that rely on the activity of peripheral immune cells 8–12 . Still, our understanding of how the microbiota modulates circulatory immune cells remains limited, particularly in humans where a lack of manipulative experiments makes inference challenging. Here we overcome this challenge by studying hundreds of hospitalized—and closely monitored—bone marrow transplantation patients as they recover from chemotherapy-induced immune ablation. This aggressive treatment causes large shifts in both circulatory immune cell and microbiota populations, allowing the relationships between the two to be studied simultaneously over time with unprecedented resolution. We analyzed daily changes in white blood cell counts from 2,235 patients, and 10,680 longitudinal fecal microbiota samples to identify bacterial genera consistently associated with those changes. Bayesian inference and validation across different patient cohorts revealed consistent associations between intestinal bacteria and peripheral immune cell dynamics in the context of immunomodulatory medications, clinical metadata and homeostatic feedbacks between peripheral immune cells. The quantification of validated microbiota associations enabled us to contrast the potency of fermentatively active, obligate anaerobic bacteria with that of medications with known immunomodulatory mechanism, and this way estimate the microbiota potential to alter peripheral immune cell dynamics directly in patients. Our analysis establishes and quantifies the link between the intestinal microbiota and immune cell dynamics in humans, with implications for microbiota-driven modulation of immunity and immunotherapies that rely on circulatory immune cells.

Published
2019
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35. Daily Chlorhexidine Gluconate Bathing Reduces the Rate of Bloodstream Infections in Adults Undergoing Inpatient Hematopoietic Stem Cell Transplantation

Author

Giri, Vinay K., primary, Kegerreis, Kristin G., additional, Ren, Yi, additional, Bohannon, Lauren M., additional, Lobaugh-Jin, Erica, additional, Messina, Julia A., additional, Matthews, Anita, additional, Allen, Deborah H., additional, Mowery, Yvonne M., additional, Saullo, Jennifer L., additional, Jung, Sin-Ho, additional, Choi, Taewoong, additional, Gasparetto, Cristina, additional, Horwitz, Mitchell E., additional, Long, Gwynn D., additional, Lopez, Richard D., additional, Rizzieri, David A., additional, Sarantopoulos, Stefanie, additional, Chao, Nelson J., additional, and Sung, Anthony D., additional

Published
2019
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36. Geriatric Assessment Identifies Impairments in Younger Candidates for Allogeneic Hematopoietic Stem Cell Transplantation

Author

Lew, Meagan V., primary, Ren, Yi, additional, Lowder, Yen P., additional, Romero, Kristi M., additional, Thompson, Jillian C., additional, Bohannon, Lauren M., additional, Cohen, Harvey, additional, Bartlett, David A., additional, Pastva, Amy M., additional, Morey, Miriam, additional, Hall, Katherine, additional, Smith, Patrick, additional, Peters, Katherine B., additional, Somers, Tamara, additional, Kelleher, Sarah, additional, Smith, Sophia, additional, Wischmeyer, Paul, additional, Lin, Pao-Hwa, additional, Thorpe, Glynnis, additional, Minor, Kerry, additional, Adler, Allison, additional, Wiggins, Kristi, additional, Hennig, Therese, additional, Helms, Tanya, additional, Welch, Renee, additional, Hicks, Whitney, additional, Eren, Margaret, additional, Porter, Rebecca, additional, Matthews, Brittany, additional, Liu, JoAnn, additional, Burleson, Jill, additional, Andrew, Whitney, additional, Aberant, Thomas, additional, Engemann, Ashley K., additional, Henshall, Bethany, additional, Darby, Maurisa, additional, Valea, Renea, additional, Proch, Christina, additional, Dellascio, Michelle, additional, Pittman, Alyssa, additional, Choi, Taewoong, additional, Gasparetto, Cristina, additional, Long, Gwynn D., additional, Lopez, Richard D., additional, Rizzieri, David A., additional, Sarantopoulos, Stefanie, additional, Horwitz, Mitchell E., additional, Chao, Nelson J., additional, and Sung, Anthony D., additional

Published
2019
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37. Decreased Mortality after the First Year of Allogeneic Hematopoietic Stem Cell Transplant in Recipients of Umbilical Cord Blood Vs. Matched Related or Matched Unrelated Donors

Author

Bohannon, Lauren M., primary, Page, Kristin M., additional, Ren, Yi, additional, Jung, Sin-Ho, additional, Giri, Vinay K., additional, Lew, Meagan V., additional, Kelly, Matthew, additional, Choi, Taewoong, additional, Gasparetto, Cristina, additional, Long, Gwynn D., additional, Lopez, Richard D., additional, Rizzieri, David A., additional, Sarantopoulos, Stefanie, additional, Chao, Nelson J., additional, Horwitz, Mitchell E., additional, and Sung, Anthony D., additional

Published
2019
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38. An association between the gut microbiota and immune cell dynamics in humans

Author

Schluter, Jonas, primary, Peled, Jonathan U., additional, Taylor, Bradford P., additional, Smith, Melody, additional, Markey, Kate A., additional, Taur, Ying, additional, Niehus, Rene, additional, Staffas, Anna, additional, Dai, Anqi, additional, Fontana, Emily, additional, Amoretti, Luigi A., additional, Wright, Roberta J., additional, Morjaria, Sejal, additional, Fenelus, Maly, additional, Pessin, Melissa S., additional, Chao, Nelson J., additional, Lew, Meagan, additional, Bohannon, Lauren, additional, Bush, Amy, additional, Sung, Anthony D., additional, Hohl, Tobias M., additional, Perales, Miguel-Angel, additional, van den Brink, Marcel R.M., additional, and Xavier, Joao B., additional

Published
2019
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40. 539 - A Phase 1 Study of the Safety and Feasibility of Improving Cardiorespiratory Fitness through a Remotely Monitored, Mobile Health Supported High Intensity Interval Training Program (REMM-HIIT)

Author

Sung, Anthony D., Miller, Hilary M., Romero, Kristi, MacDonald, Grace, Bohannon, Lauren, Molinger, Jeroen, Ren, Yi, Bush, Amy, Lew, Meagan, Cohen, Harvey J, Pastva, Amy, Jung, Sin-Ho, Shah, Nirmish R, Smith, Patrick J, Wischmeyer, Paul E, Wood, William A, Alyea, Edwin, Choi, Taewoong, Gasparetto, Cristina, Horwitz, Mitchell E., Long, Gwynn D, Lopez, Richard D, Rizzieri, David A, Sarantopoulos, Stefanie, Sullivan, Keith M, Chao, Nelson J., and Bartlett, David B

Published
2021
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41. 106 - Assessing the Feasibility of a Novel mHealth App in Hematopoietic Stem Cell Transplant Patients

Author

Racioppi, Alessandro, Dalton, Tara, Ramalingam, Sendhilnathan, Romero, Kristi, Ren, Yi, Bohannon, Lauren, Arellano, Consuelo, Jonassaint, Jude, Miller, Hilary M., Barak, Ian, Fish, Laura J., Choi, Taewoong, Gasparetto, Cristina, Long, Gwynn D, Lopez, Richard D, Rizzieri, David A, Sarantopoulos, Stefanie, Horwitz, Mitchell E., Chao, Nelson J., Shah, Nirmish R, and Sung, Anthony

Published
2021
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42. 56 - Fried’s Frailty Phenotype Predicts Overall Survival for Older Hematopoietic Cell Transplantation Recipients

Author

Sung, Anthony, Koll, Thuy, Gier, Shannon H., Lew, Meagan, Free, Marcia M, Bohannon, Lauren, Racioppi, Alessandro, Babushok, Daria V., Frey, Noelle V., Gill, Saar I., Hexner, Elizabeth O., Martin, Mary Ellen, Perl, Alexander E., Pratz, Keith W., Luger, Selina M., Stadtmauer, Edward A., Porter, David L., Loren, Alison W., Bhatt, Vijaya Raj, Gimotty, Phyllis, and McCurdy, Shannon R.

Published
2021
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44. Patient Reported Financial Toxicity in Acute Leukemia

Author

Knight, Thomas G., primary, Robinson, Myra, additional, Grunwald, Michael R., additional, Bohannon, Lauren M., additional, Blackwell, Erin, additional, Ai, Jing, additional, Ragon, Brittany, additional, Davis, Rhonda, additional, Shiflett, Cindy, additional, Ruston, Erica, additional, Trivedi, Jigar, additional, Arnall, Justin, additional, Avalos, Belinda Rene, additional, Symanowski, James T, additional, Copelan, Edward A., additional, and Gerber, Jonathan M., additional

Published
2018
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45. Hypomethylating agent (HMA) treatment as a bridge to allogeneic hematopoietic cell transplantation (HCT) for relapsed/refractory acute myeloid leukemia (RR-AML).

Author

Grunwald, Michael Richard, primary, Boselli, Danielle, additional, Bohannon, Lauren M., additional, Zimmerman, Michael Keith Alister, additional, Ai, Jing, additional, Knight, Thomas Gregory, additional, Ragon, Brittany K., additional, Plesca, Dragos, additional, Trivedi, Jigar S., additional, Avalos, Belinda Rene, additional, Copelan, Edward Alan, additional, Symanowski, James Thomas, additional, and Gerber, Jonathan Michael, additional

Published
2018
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47. AcDVP16 Induction Therapy for Acute Myeloid Leukemia

Author

Grunwald, Michael Richard, Ellenburg, Amy M., Zimmerman, Michael Keith Allister, Ai, Jing, Knight, Thomas G., Bohannon, Lauren M., Boselli, Danielle, Trivedi, Jigar, Croom, Margaret A., Anderson, William E., Symanowski, James T, Copelan, Edward A, Plesca, Dragos, and Gerber, Jonathan M.

Abstract

Introduction:The “7+3” regimen, consisting of infusional cytarabine and an anthracycline, has been the mainstay of induction therapy for acute myeloid leukemia (AML) for four decades. With this treatment, complete remission (CR) is achieved in 50-75% of patients (Fernandez 2009). An alternative induction regimen, AcDVP16, is based on the principle of timed sequential therapy (Burke 1977), whereby initial chemotherapy serves to align any residual leukemia cells in S-phase. A subsequent pulse of chemotherapy is then administered for maximum cell kill. AcDVP16 consists of 45 mg/m2/day of daunorubicin and 667 mg/m2/day of infusional cytarabine administered on days 1-3, followed by 400 mg/m2/day of etoposide on days 8-10. As configured, AcDVP16 is an anthracycline-sparing regimen that also obviates the need for a day 14 bone marrow examination. Moreover, with myriad anthracycline and cytarabine dosing options, there is arguably no standard 7+3 regimen currently in use. While AcDVP16 offers the advantage of simplicity, little data exists on outcomes with this regimen. The purpose of the present study is to assess the efficacy and safety of AcDVP16 in adult patients with AML.

Published
2017
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48. Frontline Azacitidine As a Bridge to Allogeneic Transplantation in Acute Myeloid Leukemia

Author

Grunwald, Michael Richard, Zimmerman, Michael Keith Allister, Boselli, Danielle, Bohannon, Lauren M., Robinson, Myra M, Peters, Daniel T., Ai, Jing, Knight, Thomas G., Trivedi, Jigar, Plesca, Dragos, Symanowski, James T, Copelan, Edward A, and Gerber, Jonathan M.

Abstract

Introduction:Treatment with the hypomethylating agent (HMA) azacitidine (AZA) has become a standard treatment option for older acute myeloid leukemia (AML) patients thought unfit for standard induction chemotherapy with infusional cytarabine and an anthracycline. AZA is generally well-tolerated, and carefully selected AML patients who achieve complete remission (CR) with frontline HMA therapy may subsequently improve to become suitable candidates for reduced intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (HCT) (Lübbert 2009). However, there are very limited data available regarding the use of AZA as a bridge to HCT in AML. The purpose of this study was to evaluate remission status and survival outcomes in patients treated with upfront AZA who undergo HCT.

Published
2017
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