12 results on '"Bogomolov, Valery V."'
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2. Coordination of International Risk-Reduction Investigations by the Multilateral Human Research Panel for Exploration
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Charles, John B and Bogomolov, Valery V
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Aerospace Medicine ,Man/System Technology And Life Support - Abstract
Effective use of the unique capabilities of the International Space Station (ISS) for risk reduction on future deep space missions involves preliminary work in analog environments to identify and evaluate the most promising techniques, interventions and treatments. This entails a consolidated multinational approach to biomedical research both on ISS and in ground analogs. The Multilateral Human Research Panel for Exploration (MHRPE) was chartered by the five ISS partners to recommend the best combination of partner investigations on ISS for risk reduction in the relatively short time available for ISS utilization. MHRPE will also make recommendations to funding agencies for appropriate preparatory analog work. In 2011, NASA's Human Research Program (HRP) and the Institute of Biomedical Problems (IBMP) of the Russian Academy of Science, acting for MHRPE, developed a joint US-Russian biomedical program for the 2015 one-year ISS mission (1YM) of American and Russian crewmembers. This was to evaluate the possibilities for multilateral research on ISS. An overlapping list of 16 HRP, 9 IBMP, 3 Japanese, 3 European and 1 Canadian investigations were selected to address risk-reduction goals in 7 categories: Functional Performance, Behavioral Health, Visual Impairment, Metabolism, Physical Capacity, Microbial and Human Factors. MHRPE intends to build on this bilateral foundation to recommend more fully-integrated multilateral investigations on future ISS missions commencing after the 1YM. MHRPE has also endorsed an on-going program of coordinated research on 6-month, one-year and 6-week missions ISS expeditions that is now under consideration by ISS managers. Preparatory work for these missions will require coordinated and collaborative campaigns especially in the psychological and psychosocial areas using analog isolation facilities in Houston, Köln and Moscow, and possibly elsewhere. The multilateral Human Analogs research working group (HANA) is the focal point of those planning discussions, with MHRPE coordinating between the national programs and then supporting implementation on ISS. Experience gained during preparations for the 1YM has identified improvements in both American and Russian processes to enable well-integrated investigations on all subsequent ISS expeditions. Among those is that the greatest efficiency is to be gained with investigations that are fully integrated from their conception, with co-principal investigators, a consolidated proposal and integrated plans for crewmember time and other flight-related resources. Analog investigations preceding future ISS expeditions will employ these lessons in efficiency to evaluate the techniques and tools to be validated aboard ISS. In this way, the resources and capabilities of ISS can be applied most efficiently to solving the problems facing astronauts of all nations in missions deep into the solar system.
- Published
- 2015
3. Cardiac and Vascular Responses to Thigh Cuffs and Respiratory Maneuvers on Crewmembers of the International Space Station
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Hamilton, Douglas, Sargsyan, Ashot E, Garcia, Kathleen, Ebert, Douglas, Whitson, Peggy A, Feiveson, Alan, Alferova, Irina V, Dulchavsky, Scott A, Matveev, Vladimir P, Bogomolov, Valery V, and Duncan, J. Michael
- Subjects
Aerospace Medicine - Abstract
The transition to microgravity eliminates the hydrostatic gradients in the vascular system. The resulting fluid redistribution commonly manifests as facial edema, engorgement of the external neck veins, and a decrease in leg diameter. This experiment examined the responses to modified Valsalva and Mueller maneuvers measured by cardiac and vascular ultrasound (ECHO) in a baseline steady state and during preload reduction introduced with thigh occlusion cuffs used as a counter-measure device (Braslet cuffs) measured by cardiac and vascular ultrasound examinations. Methods: Nine International Space Station crewmember subjects (Expeditions 16 - 20) were examined in 15 experiment sessions 101 +/- 46.days after launch (mean +/- SD; 33 - 185). Twenty Seven cardiac and vascular parameters were obtained with/without respiratory maneuvers before and after tightening of the Braslet cuffs. Results: Non-physicians performed diagnostic-quality cardiac and vascular ultrasound examinations using remote guidance. Three of 27 combinations of maneuvers and Braslet or Braslet alone were identified as being significant changed when compared to baseline. Eleven of 81 differences between combinations of Mueller, Valsalva or baseline were significant and related to cardiac preload reduction or increase in lower extremity venous volume. Conclusions: Acute application of Braslet occlusion cuffs causes lower extremity fluid sequestration and exerts commensurate measurable effects on cardiac performance in microgravity. Ultrasound techniques to measure the hemodynamic effects of thigh cuffs in combination with respiratory maneuvers may serve as an invaluable tool in determining the volume status of the cardiac patient at the 'microgravity bedside'.
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- 2011
4. Validation of On-Orbit Methodology for the Assessment of Cardiac Function and Changes in the Circulating Volume Using Ultrasound and Braslet-M Occlusion Cuffs
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Hamilton, Douglas, Sargsyan, Ashot E, Ebert, Douglas, Duncan, Michael, Bogomolov, Valery V, Alferova, Irina V, Matveev, Vladimir P, and Dulchavsky, Scott A
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Aerospace Medicine - Abstract
The objective of this joint U.S. - Russian project was the development and validation of an in-flight methodology to assess a number of cardiac and vascular parameters associated with circulating volume and its manipulation in long-duration space flight. Responses to modified Valsalva and Mueller maneuvers were measured by cardiac and vascular ultrasound (US) before, during, and after temporary volume reduction by means of Braslet-M thigh occlusion cuffs (Russia). Materials and Methods: The study protocol was conducted in 14 sessions on 9 ISS crewmembers, with an average exposure to microgravity of 122 days. Baseline cardiovascular measurements were taken by echocardiography in multiple modes (including tissue Doppler of both ventricles) and femoral and jugular vein imaging on the International Space Station (ISS). The Braslet devices were then applied and measurements were repeated after >10 minutes. The cuffs were then released and the hemodynamic recovery process was monitored. Modified Valsalva and Mueller maneuvers were used throughout the protocol. All US data were acquired by the HDI-5000 ultrasound system aboard the ISS (ATL/Philips, USA) during remotely guided sessions. The study protocol, including the use of Braslet-M for this purpose, was approved by the ISS Human Research Multilateral Review Board (HRMRB). Results: The effects of fluid sequestration on a number of echocardiographic and vascular parameters were readily detectable by in-flight US, as were responses to respiratory maneuvers. The overall volume status assessment methodology appears to be valid and practical, with a decrease in left heart lateral E (tissue Doppler) as one of the most reliable measures. Increase in the femoral vein cross-sectional areas was consistently observed with Braslet application. Other significant differences and trends within the extensive cardiovascular data were also observed. (Decreased - RV and LV preload indices, Cardiac Output, LV E all maneuvers, LV Stroke Volume). Conclusions: This Study: 1) Addressed specific aspects of operational space medicine and space physiology, including assessment of circulating volume disturbances 2) Expanded the applications of diagnostic ultrasound imaging and Doppler techniques in microgravity. 3) Used respiratory maneuvers against the background of acute circulating volume manipulations which appear to enhance our ability to noninvasively detect volume-dependency in a number of cardiac and vascular parameters. 4) Determined that Tei index is not clinically changed therefore contractility not altered in the face of reduced preload. 5) Determined that increased Femoral Vein Area indicating blood being sequestered in lower extremities correlates with reduced preload and cardiac output. 6) That Braslet may be the only feasible means of acutely treating high pressure pulmonary edema in reduced gravity environments.
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- 2010
5. Right Ventricular Tissue Doppler in Space Flight
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Garcia, Kathleen M, Hamilton, Douglas R, Sargsyan, Ashot E, Ebert, Douglas, Martin, David S, Barratt, Michael R, Bogomolov, Valery V, Dulchavsky, Scott A, and Duncan, J. Michael
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Aerospace Medicine - Abstract
The presentation slides review normal physiology of the right ventricle in space, general physiology of the right ventricle; difficulties in imaging the heart in space, imaging methods, tissue Doppler spectrum, right ventricle tissue Doppler, and Rt Tei Index.
- Published
- 2010
6. Cardiac and vascular responses to thigh cuffs and respiratory maneuvers on crewmembers of the International Space Station
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Hamilton, Douglas R., primary, Sargsyan, Ashot E., additional, Garcia, Kathleen, additional, Ebert, Douglas J., additional, Whitson, Peggy A., additional, Feiveson, Alan H., additional, Alferova, Irina V., additional, Dulchavsky, Scott A., additional, Matveev, Vladimir P., additional, Bogomolov, Valery V., additional, and Duncan, J. Michael, additional
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- 2012
- Full Text
- View/download PDF
7. Giant Hepatic Hemangioma and Cross-Fused Ectopic Kidney in a Spaceflight Participant
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Jennings, Richard T., primary, Garriott, Owen K., additional, Bogomolov, Valery V., additional, Pochuev, Vladimir I., additional, Morgun, Valery V., additional, and Garriott, Richard A., additional
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- 2010
- Full Text
- View/download PDF
8. The ISS Flight of Richard Garriott: a Template for Medicine and Science Investigation on Future Spaceflight Participant Missions
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Jennings, Richard T., primary, Garriott, Owen K., additional, Bogomolov, Valery V., additional, Pochuev, Vladimir I., additional, Morgun, Valery V., additional, and Garriott, Richard A., additional
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- 2010
- Full Text
- View/download PDF
9. Main results of medical support to the crews of the International Space Station
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Grigoriev, Anatoly G., primary, Bogomolov, Valery V., additional, Goncharov, Igor B., additional, Alferova, Irina V., additional, Katuntsev, Vladimir P., additional, and Osipov, Yuri Yu., additional
- Published
- 2006
- Full Text
- View/download PDF
10. International Space Station Medical Standards and Certification for Space Flight Participants.
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Bogomolov, Valery V., Castrucci, Filippo, Comtois, Jean-Marc, Damann, Volker, Davis, Jeffrey R., Duncan, J. Michael, Johnston, Smith L., Gray, Gary W., Grigoriev, Anatoly I., Koike, Yu, Kuklinski, Paul, Matveyev, Vladimir P., Morgun, Valery V., Pochuev, Vladimir I., Sargsyan, Ashot E., Shimada, Kazuhito, Straube, Ulrich, Tachibana, Shoichi, Voronkov, Yuri V., and Williams, Richard S.
- Abstract
Introduction: The medical community of the International Space Station (ISS) has developed joint medical standards and evaluation requirements for Space Flight Participants ("space tourists") which are used by the ISS medical certification board to determine medical eligibility of individuals other than professional astronauts (cosmonauts) for short-duration space flight to the ISS. These individuals are generally fare-paying passengers without operational responsibilities. Material and Context: By means of this publication, the medical standards and evaluation requirements for the ISS Space Flight Participants are offered to the aerospace medicine and commercial spaceflight communities for reference purposes. It is emphasized that the criteria applied to the ISS spaceflight participant candidates are substantially less stringent than those for professional astronauts and/or crewmembers of visiting and long-duration missions to the ISS. Conclusions: These medical standards are released by the government space agencies to facilitate the development of robust medical screening and medical risk assessment approaches in the context of the evolving commercial human space-flight industry. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
11. Medical qualification of a commercial spaceflight participant: not your average astronaut.
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Jennings RT, Murphy DM, Ware DL, Aunon SM, Moon RE, Bogomolov VV, Morgun VV, Voronkov YI, Fife CE, Boyars MC, and Ernst RD
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- Cysts diagnosis, Exercise Test, Humans, Kidney Diseases diagnosis, Lung Diseases, Interstitial diagnosis, Male, Middle Aged, Monitoring, Ambulatory, Pleurodesis, Pneumothorax diagnosis, Pneumothorax therapy, Pulmonary Atelectasis diagnosis, Pulmonary Disease, Chronic Obstructive diagnosis, Pulmonary Emphysema diagnosis, Respiratory Function Tests, Thoracic Surgery, Video-Assisted, Ventricular Premature Complexes diagnosis, Aerospace Medicine standards, Physical Examination, Space Flight standards
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Background: Candidates for commercial spaceflight may be older than the typical astronaut and more likely to have medical problems that place them at risk during flight. Since the effects of microgravity on many medical conditions are unknown, physicians have little guidance when evaluating and certifying commercial spaceflight participants. This dynamic new era in space exploration may provide important data for evaluating medical conditions, creating appropriate medical standards, and optimizing treatment alternatives for long-duration spaceflight., Case: A 57-yr-old spaceflight participant for an ISS mission presented with medical conditions that included moderately severe bullous emphysema, previous spontaneous pneumothorax with talc pleurodesis, a lung parenchymal mass, and ventricular and atrial ectopy. The medical evaluation required for certification was extensive and included medical studies and monitoring conducted in analogue spaceflight environments including altitude chambers, high altitude mixed-gas simulation, zero-G aircraft, and high-G centrifuge. To prevent recurrence of pneumothorax, we performed video-assisted thoracoscopic pleurodesis, and to assess lung masses, several percutaneous or direct biopsies. The candidate's 10-d mission was without incident., Conclusion: Non-career astronauts applying for commercial suborbital and orbital spaceflight will, at least in the near future, challenge aerospace physicians with unknowns regarding safety during training and flight, and highlight important ethical and risk-assessment problems. The information obtained from this new group of space travelers will provide important data for the evaluation and in-flight treatment of medical problems that space programs have not yet addressed systematically, and may improve the medical preparedness of exploration-class missions.
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- 2006
12. In-flight medical incidents in the NASA-Mir program.
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Gontcharov IB, Kovachevich IV, Pool SL, Navinkov OL, Barratt MR, Bogomolov VV, and House N
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- Aerospace Medicine organization & administration, History, 20th Century, Humans, International Cooperation, Life Support Systems, Program Evaluation, Russia, Space Flight organization & administration, United States, United States National Aeronautics and Space Administration, Aerospace Medicine history, Astronauts, Environmental Monitoring, First Aid, Space Flight history
- Abstract
This paper summarizes medical experience during the six NASA-Mir flights from March 14, 1995, to June 4, 1998. There were 7 U.S. astronauts who were part of 6 Mir space crews and worked jointly with 12 Russian cosmonauts. Advances in space medicine have created a safer environment; however, experience shows that crewmembers experience traumatic injuries and illnesses of diverse etiologies during spaceflight. During these joint flights both Russian and U.S. medical kits were available to crewmembers who could access either medical kit as appropriate. The Russian medical team had primary responsibility for monitoring and care of all crewmembers and analyzing medical results. When medical incidents occurred, the appropriate Russian or U.S. medical team determined the plan for diagnosis and treatment. Each team kept the other informed regarding medical situations during the flights and strictly observed the principles of medical confidentiality. A summary of medical incidents by programmatic element is described as experienced by the crewmembers and the ground support medical teams. The most frequent medical cases were small traumatic injuries to the skin and mucous membranes and fluctuations in the cardiovascular system, manifesting primarily in the form of cardiac dysrhythmias. The ability to use both the Russian medical aids and the U.S. medical kit significantly increased the effectiveness and reliability of therapeutic and prophylactic care. The degree of medical care and cooperation established precedents for integrating these systems for the medical support of expeditions on the International Space Station.
- Published
- 2005
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