201 results on '"Bogner, G"'
Search Results
2. Untersuchungsgang, Normalbefunde und Fehlerquellen in der gynäkologischen Dopplersonographie
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Bogner, G., Steiner, Horst, editor, and Schneider, Karl-Theo M., editor
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- 2018
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3. Diagnostischer Einsatz bei Adnextumoren
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Bogner, G., Steiner, Horst, editor, and Schneider, Karl-Theo M., editor
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- 2018
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4. Olaparib plus bevacizumab first-line maintenance in ovarian cancer: final overall survival results from the PAOLA-1/ENGOT-ov25 trial
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Ray-Coquard, I, Leary, A, Pignata, S, Cropet, C, González-Martin, A, Marth, C, Nagao, S, Vergote, I, Colombo, N, Mäenpää, J, Selle, F, Sehouli, J, Lorusso, D, Alia, E, Bogner, G, Yoshida, H, Lefeuvre-Plesse, C, Buderath, P, Mosconi, A, Lortholary, A, Burges, A, Medioni, J, El-Balat, A, Rodrigues, M, Park-Simon, T, Dubot, C, Denschlag, D, You, B, Pujade-Lauraine, E, Harter, P, Alia, E M Guerra, Mosconi, A M, Park-Simon, T-W, Ray-Coquard, I, Leary, A, Pignata, S, Cropet, C, González-Martin, A, Marth, C, Nagao, S, Vergote, I, Colombo, N, Mäenpää, J, Selle, F, Sehouli, J, Lorusso, D, Alia, E, Bogner, G, Yoshida, H, Lefeuvre-Plesse, C, Buderath, P, Mosconi, A, Lortholary, A, Burges, A, Medioni, J, El-Balat, A, Rodrigues, M, Park-Simon, T, Dubot, C, Denschlag, D, You, B, Pujade-Lauraine, E, Harter, P, Alia, E M Guerra, Mosconi, A M, and Park-Simon, T-W
- Abstract
Background: In the PAOLA-1/ENGOT-ov25 primary analysis, maintenance olaparib plus bevacizumab demonstrated a significant progression-free survival (PFS) benefit in newly diagnosed advanced ovarian cancer patients in clinical response after first-line platinum-based chemotherapy plus bevacizumab, irrespective of surgical status. Prespecified, exploratory analyses by molecular biomarker status showed substantial benefit in patients with a BRCA1/BRCA2 mutation (BRCAm) or homologous recombination deficiency (HRD; BRCAm and/or genomic instability). We report the prespecified final overall survival (OS) analysis, including analyses by HRD status. Patients and methods: Patients were randomized 2 : 1 to olaparib (300 mg twice daily; up to 24 months) plus bevacizumab (15 mg/kg every 3 weeks; 15 months total) or placebo plus bevacizumab. Analysis of OS, a key secondary endpoint in hierarchical testing, was planned for ∼60% maturity or 3 years after the primary analysis. Results: After median follow-up of 61.7 and 61.9 months in the olaparib and placebo arms, respectively, median OS was 56.5 versus 51.6 months in the intention-to-treat population [hazard ratio (HR) 0.92, 95% confidence interval (CI) 0.76-1.12; P = 0.4118]. Subsequent poly(ADP-ribose) polymerase inhibitor therapy was received by 105 (19.6%) olaparib patients versus 123 (45.7%) placebo patients. In the HRD-positive population, OS was longer with olaparib plus bevacizumab (HR 0.62, 95% CI 0.45-0.85; 5-year OS rate, 65.5% versus 48.4%); at 5 years, updated PFS also showed a higher proportion of olaparib plus bevacizumab patients without relapse (HR 0.41, 95% CI 0.32-0.54; 5-year PFS rate, 46.1% versus 19.2%). Myelodysplastic syndrome, acute myeloid leukemia, aplastic anemia, and new primary malignancy incidence remained low and balanced between arms. Conclusions: Olaparib plus bevacizumab provided clinically meaningful OS improvement for first-line patients with HRD-positive ovarian cancer. These prespecified expl
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- 2023
5. Long-term significance of urinary neopterin in ovarian cancer: a study by the Austrian Association for Gynecologic Oncology (AGO)
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Volgger, B.M., Windbichler, G.H., Zeimet, A.G., Graf, A.H., Bogner, G., Angleitner-Boubenizek, L., Rohde, M., Denison, U., Sliutz, G., Fuith, L.C., Fuchs, D., and Marth, C.
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- 2016
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6. Diagnostischer Einsatz bei Adnextumoren
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Bogner, G., Steiner, Horst, editor, and Schneider, Karl-Theo M., editor
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- 2012
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7. Untersuchungsgang, Normalbefunde und Fehlerquellen in der gynäkologischen Dopplersonographie
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Bogner, G., Steiner, Horst, editor, and Schneider, Karl-Theo M., editor
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- 2012
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8. 176O Final overall survival (OS) results from the phase III PAOLA-1/ENGOT-ov25 trial evaluating maintenance olaparib (ola) plus bevacizumab (bev) in patients (pts) with newly diagnosed advanced ovarian cancer (AOC)
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Nagao, S., primary, Harter, P., additional, Leary, A., additional, Cropet, C., additional, Pignata, S., additional, Fujiwara, K., additional, Gonzalez Martin, A.J., additional, Bogner, G., additional, Vergote, I., additional, Colombo, N., additional, Maenpaa, J., additional, Selle, F., additional, Schmalfeldt, B., additional, Scambia, G., additional, Guerra Alia, E.M., additional, Lefeuvre-Plesse, C., additional, Belau, A., additional, Lortholary, A., additional, Gropp-Meier, M., additional, Pujade-Lauraine, E., additional, and Ray-Coquard, I., additional
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- 2022
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9. Diagnostischer einsatz bei anderen gynäkologischen erkrankungen
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Bogner, G., Gruber, R., Steiner, Horst, editor, and Schneider, Karl-Theo M., editor
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- 2008
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10. Untersuchungsgang, Normalbefunde und Fehlerquellen in der gynäkologischen Dopplersonographie
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Bogner, G., Steiner, Horst, editor, and Schneider, Karl-Theo M., editor
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- 2008
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11. Untersuchungsgang, Normalbefunde und Fehlerquellen in der gynäkologischen Dopplersonographie
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Bogner, G., primary
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- 2017
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12. Diagnostischer Einsatz bei anderen gynäkologischen Erkrankungen
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Bogner, G., primary and Gruber, R., additional
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- 2017
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13. LBA29 Final overall survival (OS) results from the phase III PAOLA-1/ENGOT-ov25 trial evaluating maintenance olaparib (ola) plus bevacizumab (bev) in patients (pts) with newly diagnosed advanced ovarian cancer (AOC)
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Ray-Coquard, I.L., primary, Leary, A., additional, Pignata, S., additional, Cropet, C., additional, Martin, A.J. Gonzalez, additional, Bogner, G., additional, Yoshida, H., additional, Vergote, I.B., additional, Colombo, N., additional, Maenpaa, J., additional, Selle, F., additional, Schmalfeldt, B., additional, Scambia, G., additional, Alia, E.M. Guerra, additional, Lefeuvre-Plesse, C., additional, Belau, A., additional, Lortholary, A., additional, Gropp-Meier, M., additional, Pujade-Lauraine, E., additional, and Harter, P., additional
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- 2022
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14. Lumineszenzdioden
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Oberschmid, R., Bogner, G., Voges, Edgar, editor, and Petermann, Klaus, editor
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- 2002
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15. Efficacy of maintenance olaparib plus bevacizumab according to clinical risk in patients with newly diagnosed, advanced ovarian cancer in the phase III PAOLA-1/ENGOT-ov25 trial
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Harter, P, Mouret-Reynier, M, Pignata, S, Cropet, C, Gonzalez-Martin, A, Bogner, G, Fujiwara, K, Vergote, I, Colombo, N, Nottrup, T, Floquet, A, El-Balat, A, Scambia, G, Guerra Alia, E, Fabbro, M, Schmalfeldt, B, Hardy-Bessard, A, Runnebaum, I, Pujade-Lauraine, E, Ray-Coquard, I, Mouret-Reynier, MA, Nottrup, TJ, Guerra Alia, EM, Hardy-Bessard, A-C, Harter, P, Mouret-Reynier, M, Pignata, S, Cropet, C, Gonzalez-Martin, A, Bogner, G, Fujiwara, K, Vergote, I, Colombo, N, Nottrup, T, Floquet, A, El-Balat, A, Scambia, G, Guerra Alia, E, Fabbro, M, Schmalfeldt, B, Hardy-Bessard, A, Runnebaum, I, Pujade-Lauraine, E, Ray-Coquard, I, Mouret-Reynier, MA, Nottrup, TJ, Guerra Alia, EM, and Hardy-Bessard, A-C
- Abstract
Objectives: Adding maintenance olaparib to bevacizumab provided a significant progression-free survival (PFS) benefit in patients with newly diagnosed, advanced ovarian cancer in the randomized, double-blind PAOLA-1/ENGOT-ov25 trial (NCT02477644). We analyzed PFS by clinical risk and biomarker status. Methods: Patients received olaparib 300 mg twice daily for up to 24 months plus bevacizumab 15 mg/kg every 3 weeks for up to 15 months in total, or placebo plus bevacizumab. This post hoc exploratory analysis evaluated PFS in patients classified as higher risk (stage III with upfront surgery and residual disease or neoadjuvant chemotherapy; stage IV) or lower risk (stage III with upfront surgery and no residual disease), and by biomarker status. Results: Of 806 randomized patients, 74% were higher risk and 26% were lower risk. After a median 22.9 months of follow-up, PFS favored olaparib plus bevacizumab versus placebo plus bevacizumab in higher-risk patients (hazard ratio [HR] 0.60; 95% confidence interval [CI] 0.49–0.74) and lower-risk patients (0.46; 0.30–0.72). Olaparib plus bevacizumab provided a substantial PFS benefit versus bevacizumab alone in the homologous recombination deficiency (HRD)-positive subgroup (higher risk: HR 0.39; 95% CI 0.28–0.54 and lower risk: 0.15; 0.07–0.30), with 24-month PFS rates in lower-risk patients of 90% versus 43%, respectively (Kaplan–Meier estimates). Conclusions: In PAOLA-1, maintenance olaparib plus bevacizumab provided a substantial PFS benefit in HRD-positive patients with a reduction of risk of progression or death of 61% in the higher-risk group and of 85% in the lower-risk group compared with bevacizumab alone.
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- 2022
16. Diagnostischer Einsatz bei anderen Entitäten
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Bogner, G., Gruber, R., Steiner, H., editor, and Schneider, K. T. M., editor
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- 2000
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17. Blutversorgung, Physiologie und Neoangiogenese des inneren weiblichen Genitales
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Gruber, R., Bogner, G., Steiner, H., Schaffer, H. K., Staudach, A., Steiner, H., editor, and Schneider, K. T. M., editor
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- 2000
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18. Untersuchungsgang und Normalbefunde in der gynäkologischen Dopplersonographie
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Bogner, G., Steiner, H., editor, and Schneider, K. T. M., editor
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- 2000
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19. Fehlerquellen und Reproduzierbarkeit
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Gruber, R., Bogner, G., Steiner, H., editor, and Schneider, K. T. M., editor
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- 2000
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20. Influence of so far neglected psychosomatic factors, BMI and smoking on pregnancy-induced hypertension (PIH)
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Rauchfuss, M., Fischer, T., Bogner, G., and Maier, B.
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- 2012
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21. European Progress in Cryopower Transmission
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Bogner, G. and Timmerhaus, K. D., editor
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- 1995
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22. 739P Efficacy and safety of maintenance olaparib and bevacizumab (bev) in ovarian cancer (OC) patients (pts) aged ≥65 years (y) from the PAOLA-1/ENGOT-ov25 first-line trial
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Sabatier, Renaud, Vicier, Cécile, Garnier, Séverine, Guille, Arnaud, Carbuccia, Nadine, Isambert, Nicolas, Dalenc, Florence, Robert, Marie, Levy, Christelle, Pakradouni, Jihane, Adelaïde, José, Chaffanet, Max, Sfumato, Patrick, Mamessier, Emilie, Bertucci, François, Goncalves, Anthony, Mezni, Essia, Evans, Catherine Karine, Chinot, Olivier, Loschi, Alain, Arnaud, Sylvie, Mellinas, Marie, Bay, Jacques-Olivier, Bouleuc, Carole, Firmin, Nelly, Gandemer, Virginie, Magne, Nicolas, Orbach, Daniel, Penel, Nicolas, Rodrigues, Manuel, Thiery-Vuillemin, Antoine, Wislez, Marie, L’allemain, Gilles, Robert, Jacques, Colombo, Nicoletta, Dubot, Coraline, Lorusso, Domenica, Caceres, M. Valeria, Hasegawa, Kosei, Shapira-Frommer, Ronnie, Tewari, Krishnansu, Salman, Pamela, Hoyos Usta, Edwin, Yañez, Eduardo, Gümüş, Mahmut, Olivera Hurtado de Mendoza, Mivael, Samouëlian, Vanessa, Castonguay, Vincent, Arkhipov, Alexander, Toker, Sarper, Li, Kan, Keefe, Stephen, Monk, Bradley, Oaknin, Ana, Tinker, Anna, Gilbert, Lucy, Mathews, Cara, Brown, Jubilee, Barretina-Ginesta, Maria-Pilar, Moreno, Victor, Gravina, Adriano, Abdeddaim, Cyril, Banerjee, Susana, Guo, Wei, Danaee, Hadi, Im, Ellie, de Nonneville, Alexandre, Zemmour, Christophe, Frank, Sophie, Joly, Florence, Ray-Coquard, Isabelle, Costaz, Hèlène, Classe, Jean-Marc, Floquet, Anne, de La Motte Rouge, Thibault, Colombo, Pierre-Emmanuel, Sauterey, Baptiste, Leblanc, Eric, Pomel, Christophe, Marchal, Frédéric, Barranger, Emmanuel, Savoye, Aude-Marie, Guillemet, Cécile, Petit, Thierry, Pautier, Patricia, Rouzier, Roman, Gladieff, Laurence, Simon, Gaëtane, Courtinard, Coralie, Rousset-Rouviere, Sandrine, Rochigneux, Philippe, Chrétien, Anne-Sophie, Fattori, Stéphane, Gorvel, Laurent, Provansal, Magali, Lambaudie, Eric, Olive, Daniel, Martin, Johan, Guérin, Mathilde, Monneur, Audrey, Tassy, Louis, Tarpin, Carole, Extra, Jean-Marc, Viret, Frédéric, Pierga, Jean-Yves, Curé, Hervé, Abulnaja, Rakan, Bidard, François-Clément, Mari, Roxane, Narducci, Fabrice, Cappiello, Maria-Antonietta, Rousseau, Fréderique, Blache, Guillaume, Birnbaum, Daniel, Cropet, C., Montegut, C., Frindte, J., Cinieri, S., Guerra-Alia, E.M., Bogner, G., Yoshida, H., Vergote, I., Hietanen, S., Largillier, R., Canzler, U., Gratet, A., Marmé, F., Pujade-Lauraine, E., Favier, L., Ray-Coquard, I.L., Department of Medical Oncology, Institut Paoli-Calmettes, 232 Boulevard Sainte Marguerite, 13009 Marseille, France., Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
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Oncology ,medicine.medical_specialty ,Bevacizumab ,business.industry ,First line ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Hematology ,medicine.disease ,Olaparib ,chemistry.chemical_compound ,chemistry ,Internal medicine ,Medicine ,business ,Ovarian cancer ,medicine.drug - Abstract
International audience; 5548 Background: Ovarian cancer is the leading cause of death by gynecological cancer. Complete surgery remains one of the main prognostic factors. Laparoscopic exploration is mandatory to assess surgical resectability at diagnosis or after neoadjuvant chemotherapy. However, there is no clinical or biological marker that can correctly predict resectability and may be able to avoid a second laparoscopic exploration for initially unresectable diseases. Our aim was to assess circulating tumor DNA (ctDNA) value as a predictive non-invasive marker of evolution towards resectability for patients with epithelial ovarian cancer receiving first-line chemotherapy. Methods: We explored in this work one of the secondary objectives of the CIDOC study (NCT03302884). CIDOC is a multicenter prospective study aiming to explore ctDNA value as early marker of disease relapse after first-line treatment for epithelial ovarian cancer. Patients with mucinous histology or early stages not requiring chemotherapy are excluded. Plasma samples are collected at diagnosis, during neoadjuvant chemotherapy, and during follow-up. After DNA extraction, panel-based next generation sequencing is performed on both tumor samples and germline DNA, and somatic mutations of interest are selected for ctDNA monitoring. ctDNA analyses are conducted using droplet digital PCR (BioRad QX200) by measuring the variant allele fraction (VAF) of previously identified mutations. Results: This intermediary analysis has included 47 patients diagnosed between March 2017 and December 2019. Median age was 69 years old (48 – 84). Most of the patients had advanced disease (89.4% stage FIGO III or IV), serous histology (94.8%), and high grade tumor (92.3%). Most of the patients underwent complete interval cytoreductive surgery (76.3% vs 17.4% complete upfront surgery). Most of the tumors had TP53 mutations (85.1%), following by alterations involving DNA repair genes (38.3%). Median cell-free DNA concentration at baseline was 0.38 ng/µL (0 – 12.8). ctDNA was identified in 92.1% of patients at baseline with a median VAF of 1.84% (0 – 42.52%). ctDNA VAF was correlated to the peritoneal dissemination ( p= 0.039) assessed with the peritoneal cancer index. ctDNA clearance after preoperative chemotherapy tended to be correlated to achievement of complete interval surgery for patients receiving neoadjuvant chemotherapy ( p= 0.108). Conclusions: ctDNA may be a promising non-invasive marker to assess peritoneal cancer spreading and to predict surgical resectability after neoadjuvant chemotherapy. If confirmed in larger populations, this may enable to avoid additional surgical explorations for patients who remain ctDNA positive after chemotherapy. Clinical trial information: NCT03302884.
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- 2021
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23. 951 Primary imiquimod treatment versus surgery for vulvar intraepithelial neoplasia – PITVIN study. A randomized clinical trial
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Trutnovsky, G, primary, Reich, O, additional, Joura, E, additional, Ciresa-König, A, additional, Widschwendter, A, additional, Schauer, C, additional, Bogner, G, additional, Jan, Z, additional, Holter, M, additional, and Tamussino, K, additional
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- 2021
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24. Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries
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Ahmad T., Bouwman R. A., Grigoras I., Aldecoa C., Hofer C., Hoeft A., Holt P., Buhre W., Pearse R. M., Clavien P. -A., Demartines N., Grocott M., Haddow J., Moreno R., Pritchard N., Rhodes A., Wilson M., Ahmed T., Halliwell R., Shulman M., Myles P., Schmid W., Hiesmayr M., Wouters P., De Hert S., Lobo S., Beattie S., Wijeysundera D., Fang X., Rasmussen L., Futier E., Biais M., Venara A., Slim K., Sander M., Koulenti D., Arvaniti K., Chan M., Kulkarni A., Chandra S., Tantri A., Geddoa E., Abbas M., Della Rocca G., Sivasakthi D., Mansor M., Luna P., Bouwman A., Beavis V., Campbell D., Short T., Osinaike T., Matos R., Kirov M., Protsenko D., Biccard B., Chew M., Hubner M., Ditai J., Szakmany T., Fleisher L., Ferguson M., MacMahon M., Cherian R., Currow H., Kanathiban K., Gillespie D., Pathmanathan E., Phillips K., Reynolds J., Rowley J., Douglas J., Kerridge R., Garg S., Bennett M., Jain M., Alcock D., Terblanche N., Cotter R., Leslie K., Stewart M., Zingerle N., Clyde A., Hambidge O., Rehak A., Cotterell S., Huynh W. B. Q., McCulloch T., Ben-Menachem E., Egan T., Cope J., Fellinger P., Markus P., Haselberger S., Holaubek C., Lichtenegger P., Scherz F., Hoffer F., Cakova V., Eichwalder A., Fischbach N., Klug R., Schneider E., Vesely M., Wickenhauser R., Gernot K., Leitgeb M., Lang F., Toro N., Bauer M., Laengle F., Haberl C., Mayrhofer T., Trybus C., Buerkle C., Forstner K., Germann R., Rinoesl H., Schindler E., Trampitsch E., Bogner G., Dankl D., Duenser M., Fritsch G., Gradwohl I. -M., Hartmann A., Hoelzenbein T., Jaeger T., Landauer F., Lindl G., Lux M., Steindl J., Stundner O., Szabo C., Bidgoli J., Verdoodt H., Forget P., Kahn D., Lois F., Momeni M., Pregardien C., Pospiech A., Steyaert A., Veevaete L., De Kegel D., De Jongh K., Foubert L., Smitz C., Vercauteren M., Poelaert J., Van Mossevelde V., Abeloos J., Bouchez S., Coppens M., De Baerdemaeker L., Deblaere I., De Bruyne A., Fonck K., Heyse B., Jacobs T., Lapage K., Moerman A., Neckebroek M., Parashchanka A., Roels N., Van Den Eynde N., Vandenheuvel M., Van Limmen J., Vanluchene A., Vanpeteghem C., Wyffels P., Huygens C., Vandenbempt P., Van De Velde M., Dylst D., Janssen B., Schreurs E., Aleixo F. B., Candido K., Batista H. D., Guimaraes M., Guizeline J., Hoffmann J., Lobo F. R. M., Nascimento V., Nishiyama K., Pazetto L., Souza D., Rodrigues R. S., Dos Santos A. M. V., Jardim J., Sa Malbouisson L. M., Silva J., Do Nascimento P., Baio T. H., De Castro G. I. P., Oliveira H. R. W., Amendola C. P., Cardoso G., Ortega D., Brotto A. F., De Oliveira M. C., Rea-Neto A., Dias F., Travi M. E., Zerman L., Azambuja P., Knibel M. F., Martins A., Almeida W., Neto C. N., Tardelli M. A., Caser E., MacHado M., Aguzzoli C., Baldisserotto S., Tabajara F. B., Bettega F., Rodrigues L. H. C., De Gasperi J., Faina L., Nolasco M. F., Da Costa Fischer B. F., De Campos Ferreira M. F., Hartmann C., Kliemann M., Ribeiro G. L. H., Fraga J. M., Netto T. M., Pozza L. V., Wendling P. R., Azevedo C., Garcia J., Lopes M., Maia B., Maselli P., Melo R., Mendes W., Neves M., Ney J., Piras C., Applewhaite C., Carr A., Chow L., Duttchen K., Foglia J., Greene M., Hinther A., Houston K., McCormick T. J., Mikhayel J., Montasser S., Ragan A., Suen A., Woolsey A., Yu H. C., Funk D., Stephen D., Regina D., Heather D., Faisal D., Pridham J., Rowe B., Sampson S., Thiessen B., Zbitnew G., Bernard A., George R., Jones P., Moor R., Siddiqui N., Wolfer A., Tran D., Winch D., Dobson G., Montasser O., Hall R., Baghirzada L., Curley G., Dai S. Y., Hare G., Lee E., Shastri U., Tsui A., Yagnik A., Alvares D., Choi S., Dwyer H., Flores K., McCartney C., Somascanthan P., Carroll J., Pazmino-Canizares J., Ami N., Chan V., Perlas A., Argue R., Huang Y., Lavis K., Mayson K., Cao Y., Gao H., Hu T., Lv J., Yang J., Yang Y., Zhong Y., Zhou J., Zou X., He M., Li X., Luo D., Wang H., Yu T., Chen L., Wang L., Cai Y., Cao Z., Li Y., Lian J., Sun H., Wang S., Wang Z., Wang K., Zhu Y., Du X., Fan H., Fu Y., Huang L., Hwan H., Luo H., Qu P. -S., Tao F., Wang G., Zhang Y., Zhang X., Chen C., Wang W., Liu Z., Fan L., Tang J., Chen Y., Han Y., Huang C., Liang G., Shen J., Wang J., Yang Q., Zhen J., Zhou H., Chen J., Chen Z., Meng B., Ye H., Bi Y., Cao J., Guo F., Lin H., Liu Y., Lv M., Shi P., Song X., Sun C., Sun Y., Wang Y., Zhang M., Chen R., Hou J., Leng Y., Meng Q. -T., Qian L., Shen Z. -Y., Xia Z. -Y., Xue R., Zhao B., Zhou X. -J., Chen Q., Guo H., Guo Y., Qi Y., Wei J., Zhang W., Zheng L., Bao Q., Fei Y., Hu N., Hu X., Lei M., Lv X., Miao F., Ouyang L., Shen C., Wang D., Wu C., Xu L., Yuan J., Zhang L., Zhang H., Zhao J., Zhao C., Zhao L., Zheng T., Zhou D., Zhou C., Lu K., Zhao T., He C., Chen H., Chen S., Cheng B., He J., Jin L., Li C., Li H., Pan Y., Shi Y., Wen X. H., Wu S., Xie G., Zhang K., Lu X., Chen F., Liang Q., Lin X., Ling Y., Liu G., Tao J., Yang L., Cheng Z., Dai H., Feng Y., Hou B., Gong H., Hua C., Huang H., Huang J., Jiang Z., Li M., Lin J., Liu M., Liu W., Luo F., Ma L., Min J., Shi X., Song Z., Wan X., Xiong Y., Yang S., Zhang Q., Zhao W., Zhu X., Bai Y., Dai Q., Geng W., Han K., He X., Ji B., Jia D., Jin S., Li Q., Liang D., Luo S., Lwang L., Mo Y., Qi X., Qian M., Qin J., Ren Y., Xie J., Yan Y., Yao Y., Zhuang X., Ai Y., Du F., He L., Li Z., Li L., Meng S., Yuan Y., Zhang E., Zhang J., Zhao S., Ji Z., Pei L., Dong B., Li J., Miao Z., Mu H., Qin C., Su L., Wen Z., Xie K., Yu Y., Yuan F., Xiao W., Zhu Z., Fu K., Hu R., Huang S., Liang Y., Yu S., Guo Z., Jing Y., Tang N., Wu J., Yuan D., Zhang R., Zhao X., Bai H. -P., Liu C. -X., Liu F. -F., Ren W., Wang X. -L., Xu G. -J., Li B., Ou Y., Tang Y., Yao S., Zhang S., Kong C. -C., Liu B., Wang T., Lu B., Xia Y., Cai F., Chen P., Hu S., Xu Q., Hu L., Jing L., Liu Q., Dan Z., Qiu X., Ren Q., Tong Y., Wen Y., Wu Q., Xia J., Xiong X., Xu S., Yang T., Yin N., Zeng Q., Zhang B., Zheng K., Cang J., Fan Y., Fu S., Ge X., Guo B., Huang W., Jiang L., Jiang X., Shan Q., Wang F., Christiansen I. 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K., Wilson, A., Commey, T., Foot, H., Glover, L., Gupta, A., Lancaster, N., Levin, J., Mackenzie, F., Mestanza, C., Nofal, E., Pout, L., Varden, R., Wild, J., Jones, S., Moreton, S., Pulletz, M., Davies, C., Martin, M., Thomas, S., Burns, K., Mcarthur, C., Patel, P., Lau, G., Rich, N., Davis, F., Lyons, R., Port, B., Prout, R., Smith, C., Adelaja, Y., Bennett, V., Bidd, H., Dumitrescu, A., Fox, J., Keen, A., Mguni, N., Ong, C., Adams, G., Boshier, P., Brown, R., Butryn, I., Chatterjee, J., Freethy, A., Lockwood, G., Tsakok, M., Tsiligiannis, S., Peat, W., Stephenson, L., Bradburn, M., Pick, S., Cunha, P., Olagbaiye, O., Tayeh, S., Packianathaswamy, B., Abernethy, C., Balasubramaniam, M., Bennett, R., Bolton, D., Martinson, V., Bell, S., Heather, B., Kushakovsky, V., Alcock, L., Alexander, H., Anderson, C., Baker, P., Brookes, M., Cawthorn, L., Cirstea, E., Clarkson, R., Colling, K., Coulter, I., Das, S., Haigh, K., Hamdan, A., Hugill, K., Kottam, L., Lisseter, E., Mawdsley, M., Mcgivern, J., Padala, K., Phelps, V., Kumar, V. R., Stewart, K., Towse, K., Tregonning, J., Vahedi, A., Walker, A., Baines, D., Bilolikar, A., Chande, S., Copley, E., Dunk, N., Kulkarni, R., Kumar, P., Metodiev, Y., Ncomanzi, D., Raithatha, B., Raymode, P., Szafranski, J., Twohey, L., Watt, P., Weatherall, L., Weatherill, J., Whitman, Z., Wighton, E., Abayasinghe, C., Chan, A., Darwish, S., Gill, J., Glasgow, E., Hadfield, D., Harris, C., Hopkins, P., Kochhar, A., Kunst, G., Mellis, C., Pool, A., Riozzi, P., Selman, A., Smith, E. -J., Vele, L., Gercek, Y., Guy, K., Holden, D., Watson, N., Whysall, K., Andreou, P., Hales, D., Thompson, J., Bowrey, S., Mcdonald, S., Gilmore, J., Hills, V., Kelly, C., Kelly, S., Lloyd, G., Abbott, T., Gall, L., Torrance, H., Vivian, M., Berntsen, E., Nolan, T., Turner, A., Vohra, A., Brown, A., Clark, R., Coughlan, E., Daniel, C., Patvardhan, C., Pearson, R., Predeep, S., Saad, H., Shanmugam, M., Varley, S., Wylie, K., Cooper, L., Makowski, A., Misztal, B., Moldovan, E., Pegg, C., Donovan, A., Foot, J., Large, S., Claxton, A., Netke, B., Armstrong, R., Calderwood, C., Kwok, A., Mohr, O., Oyeniyi, P., Patnaik, L., Post, B., Ali, S., Arshad, H., Baker, G., Brenner, L., Brincat, M., Brunswicker, A., Cox, H., Cozar, O. I., Cheong, E., Durst, A., Fengas, L., Flatt, J., Glister, G., Narwani, V., Photi, E., Rankin, A., Rosbergen, M., Beaton, C., Horn, R., Hunt, J., Rousseau, G., Stancombe, L., Absar, M., Allsop, J., Drinkwater, Z., Hodgkiss, T., Smith, K., Alexander-Sefre, F., Campey, L., Dudgeon, L., Hall, K., Hitchcock, R., James, L., Winstone, U., Ahmad, N., Bauchmuller, K., Harrison, J., Jeffery, H., Miller, D., Pinder, A., Pothuneedi, S., Rosser, J., Sanghera, S., Swift, D., Walker, R., Bester, D., Cavanagh, S., Cripps, H., Daniel, H., Lynch, J., Pyke, S., Scholefield, J., Whitworth, H., Bottrill, F., Ramalingam, G., Webb, S., Akerman, N., Antill, P., Bourner, L., Buckley, S., Castle, G., Charles, R., Eggleston, C., Foster, R., Gill, S., Lindley, K., Lklouk, M., Lowery, T., Martin, O., Milne, D., O'Connor, P., Ratcliffe, A., Rose, A., Smith, A., Varma, S., Ward, J., Barcraft-Barnes, H., Camsooksai, J., Colvin, C., Reschreiter, H., Tbaily, L., Venner, N., Hamilton, C., Kelly, L., Toth-Tarsoly, P., Dodsworth, K., Foord, D., Gordon, P., Hawes, E., Lamb, N., Mouland, J., Nightingale, J., Rose, S., Schrieber, J., Al 'Amri, K., Aladin, H., Arshad, M. A., Barraclough, J., Bentley, C., Bergin, C., Carrera, R., Clarkson, A., Collins, M., Denham, S., Griffiths, E., Ip, P., Jeyanthan, S., Joory, K., Kaur, S., Marriott, P., Mitchell, N., Nagaiah, S., Nilsson, A., Parekh, N., Pope, M., Seager, J., Serag, H., Tameem, A., Thomas, A., Thunder, J., Torrance, A., Vohra, R., Whitehouse, A., Wong, T., Blunt, M., Wong, K., Giles, J., Reed, I., Weller, D., Bell, G., Birch, J., Damant, R., Maiden, J., Mewies, C., Prince, C., Radford, J., Reynolds, T., Balain, B., Banerjee, R., Barnett, A., Burston, B., Edwards, J., Evans, C., Ford, D., Gallacher, P., Hill, S., Jaffray, D., Karlakki, S., Kennedy, J., Kiely, N., Lewthwaite, S., Marquis, C., Ockendon, M., Phillips, S., Pickard, S., Richardson, J., Roach, R., Smith, T., Spencer-Jones, R., Steele, N., Steen, J., Van Liefland, M., White, S., Faulds, M., Harris, M., Nicol, S., Pearson, S. A., Chukkambotla, S., Andrew, A., Attrill, E., Campbell, G., Datson, A., Fouracres, A., Graterol, J., Graves, L., Hong, B., Ishimaru, A., Karthikeyan, A., King, H., Lawson, T., Lee, G., Lyons, S., Hall, A. M., Mathoulin, S., Mcintyre, E., Mclaughlin, D., Mulcahy, K., Paddle, J., Robbins, J., Sung, W., Tayo, A., Trembath, L., Venugopal, S., Wigmore, G., Boereboom, C., Downes, C., Humphries, R., Melbourne, S., Tou, S., Ullah, S., Batchelor, N., Boxall, L., Broomby, R., Deen, T., Hellewell, A., Helliwell, L., Hutchings, M., Hutchins, D., Keenan, S., Mackie, D., Potter, A., Smith, F., Stone, L., Thorpe, K., Wassall, R., Woodgate, A., Baillie, S., Campbell, T., James, S., King, C., De Araujo, D. M., Martin, D., Morkane, C., Neely, J., Rajendram, R., Burton, M., James, K., Keevil, E., Minik, O., Morgan, J., Musgrave, A., Rajanna, H., Roberts, T., Adamson, M., Jumbe, S., Kendall, J., Muthuswamy, M. B., Cruikshanks, A., Wrench, I., Zeidan, L., Ardern, D., Harris, B., Hellstrom, J., Martin, J., Thomas, R., Varsani, N., Brown, C. W., Docherty, P., Gillies, M., Mcgregor, E., Usher, H., Craig, J., Bodger, P., Creary, T., Everingham, K., Fowler, A., Hewson, R., Ijuo, E., Januszewska, M., Jones, T., Kantsedikas, I., Lahiri, S., Mclean, A. L., Niebrzegowska, E., Phull, M., Wickboldt, N., Baldwin, J., Doyle, D., Mcmullan, S., Oladapo, M., Owen, T., Williams, A., Gregory, P., Husain, T., Kirk-Bayley, J., Mathers, E., Montague, L., Harper, M., Jack, J., Ridley, C., Avis, J., Cook, T., Dali-Kemmery, L., Kerslake, I., Lambourne, V., Pearson, A., Boyd, C., Callaghan, M., Lawson, C., Mccrossan, R., Nesbitt, V., O'Connor, L., Sinclair, R., Farid, N., Morgese, C., Bhatia, K., Karmarkar, S., Ahmed, J., Branagan, G., Hutton, M., Swain, A., Brookes, J., Cornell, J., Dolan, R., Hulme, J., Van Vuuren, A. J., Jowitt, T., Kalashetty, G., Lloyd, F., Kiran, Patel, Sherwood, N., Brown, L., Chandler, B., Deighton, K., Emma, T., Haunch, K., Cheeseman, M., Dent, K., Gray, C., Hood, M., Jones, D., Juj, J., Rao, R., Walker, T., Al Anizi, M., Cheah, C., Cheing, Y., Coutinho, F., Gondo, P., Hadebe, B., Hove, M. O., Khader, A., Krishnachetty, B., Rhodes, K., Sokhi, J., Baker, K. -A., Bertram, W., Looseley, A., Mouton, R., Hanna, G., Arnold, G., Arya, S., Balfoussia, D., Baxter, L., Harris, J., Jones, C., Knaggs, A., Markar, S., Perera, A., Scott, A., Shida, A., Sirha, R., Wright, S., Frost, V., Andrews, E., Arrandale, L., Barrett, S., Cifra, E., Cooper, M., Dragnea, D., Elna, C., Maclean, J., Meier, S., Milliken, D., Munns, C., Ratanshi, N., Ramessur, S., Salvana, A., Watson, A., Ali, H., Critchley, R., Endersby, S., Hicks, C., Liddle, A., Pass, M., Ritchie, C., Thomas, C., Too, L., Welsh, S., Gill, T., Johnson, J., Reed, J., Davis, E., Papadopoullos, S., Attwood, C., Biffen, A., Boulton, K., Gray, S., Hay, D., Mills, S., Montgomery, J., Riddell, R., Simpson, J., Bhardwaj, N., Paul, E., Uwubamwen, N., Alexander, M., Arrich, J., Arumugam, S., Blackwood, D., Boggiano, V., Lam, Y., Chatterjee, D., Chhabra, A., Christian, R., Costelloe, H., Matthewman, M. C., Dalton, E., Darko, J., Davari, M., Dave, T., Deacon, M., Deepak, S., Edmond, H., Ellis, J., El-Sayed, A., Eneje, P., English, R., Ewe, R., Foers, W., Franklin, J., Gallego, L., Garrett, E., Goldberg, O., Goss, H., Greaves, R., Harris, R., Hennings, C., Jones, E., Kamali, N., Kokkinos, N., Lewis, C., Lignos, L., Malgapo, E. V., Malik, R., Milne, A., Mulligan, J. -P., Nicklin, P., Palipane, N., Parsons, T., Piper, R., Prakash, R., Ramesh, B., Rasip, S., Reading, J., Rela, M., Reyes, A., Stephens, R., Rooms, M., Shah, K., Simons, H., Solanki, S., Spowart, E., Stevens, A., Waggett, H., Yassaee, A., Kennedy, A., Scott, S., Somanath, S., Berg, A., Hernandez, M., Nanda, R., Tank, G., Wilson, N., Wilson, D., Al-Soudaine, Y., Baldwin, M., Cornish, J., Davies, Z., Davies, L., Edwards, M., Frewer, N., Gallard, S., Glasbey, J., Harries, R., Hopkins, L., Kim, T., Koompirochana, V., Lawson, S., Lewis, M., Makzal, Z., Scourfield, S., Ahmad, Y., Bates, S., Blackwell, C., Bryant, H., Collins, H., Coulter, S., Cruickshank, R., Daniel, S., Daubeny, T., Golder, K., Hawkins, L., Helen, B., Hinxman, H., Levett, D., Salmon, K., Seaward, L., Ben, L., Tyrell, B., Wadams, B., Walsgrove, J., Dickson, J., Constantin, K., Karen, M., O'Brien, P., O'Donohoe, L., Payne, H., Sundayi, S., Walker, E., Brooke, J., Cardy, J., Humphreys, S., Kessack, L., Kubitzek, C., Kumar, S., Cotterill, D., Hodzovic, E., Hosdurga, G., Miles, E., Saunders, G., Campbell, M., Chan, P., Jemmett, K., Raj, A., Naik, A., Oshowo, A., Ramamoorthy, R., Shah, N., Sylvan, A., Blyth, K., Burtenshaw, A., Freeman, D., Johnson, E., Lo, P., Martin, T., Plunkett, E., Wollaston, J., Allison, J., Carroll, C., Craw, N., Craw, S., Pitt-Kerby, T., Rowland-Axe, R., Spurdle, K., Mcdonald, A., Simon, D., Sinha, V., Banner-Goodspeed, V., Boone, M., Campbell, K., Lu, F., Scannell, J., Sobol, J., Balajonda, N., Clemmons, K., Conde, C., Elgasim, M., Funk, B., Hopkins, T., Olaleye, O., Omer, O., Pender, M., Porto, A., Waweru, P., Yeh, E., Bodansky, D., Evans, A., Kleopoulos, S., Maril, R., Mathney, E., Sanchez, A., Tinuoye, E., Bateman, B., Eng, K., Jiang, N., Ladha, K., Needleman, J., Chen, L. -L., Lane, R., Robinowitz, D., Ghushe, N., Irshad, M., O'Connor, J., Patel, S., Takemoto, S., Wallace, A., Mazzeffi, M., Rock, P., Wallace, K., Chua, P., Mattera, M., Sharar, R., Thilen, S., Treggiari, M., Morgan, A., Sofjan, I., Subramaniam, K., Avidan, M., Maybrier, H., Muench, M., and Wildes, T.
- Subjects
operative ,Male ,Pediatrics ,GLOBAL HEALTH ,Cohort Studies ,0302 clinical medicine ,Postoperative Complications ,030202 anesthesiology ,surgical procedures, operative, mortality ,Health care ,statistics and numerical data ,030212 general & internal medicine ,Hospital Mortality ,Prospective Studies ,Prospective cohort study ,Aged, 80 and over ,HIGH-RISK SURGERY ,COMPLICATIONS ,OUTCOMES ,Incidence (epidemiology) ,Middle Aged ,PATIENT MORTALITY ,Female ,SURGICAL MORTALITY ,Cohort study ,Adult ,medicine.medical_specialty ,methods ,03 medical and health sciences ,Anesthesiology ,medicine ,QUALITY ,Humans ,Elective surgery ,postoperative care, statistics and numerical data ,Aged ,Quality of Health Care ,Postoperative Care ,business.industry ,Postoperative complication ,mortality ,CANCER-SURGERY ,surgical procedures ,Anesthesiology and Pain Medicine ,Logistic Models ,VOLUME ,postoperative care, methods ,Human medicine ,Complication ,business - Abstract
Background.The incidence and impact of postoperative complications are poorly described. Failure-to-rescue, the rate of death following complications, is an important quality measure for perioperative care but has not been investigated across multiple health care systems.Methods.We analysed data collected during the International Surgical Outcomes Study, an international 7-day cohort study of adults undergoing elective inpatient surgery. Hospitals were ranked by quintiles according to surgical procedural volume (Q1 lowest to Q5 highest). For each quintile we assessed in-hospital complications rates, mortality, and failure-to-rescue. We repeated this analysis ranking hospitals by risk-adjusted complication rates (Q1 lowest to Q5 highest).Results.A total of 44 814 patients from 474 hospitals in 27 low-, middle-, and high-income countries were available for analysis. Of these, 7508 (17%) developed one or more postoperative complication, with 207 deaths in hospital (0.5%), giving an overall failure-to-rescue rate of 2.8%. When hospitals were ranked in quintiles by procedural volume, we identified a three-fold variation in mortality (Q1: 0.6% vs Q5: 0.2%) and a two-fold variation in failure-to-rescue (Q1: 3.6% vs Q5: 1.7%). Ranking hospitals in quintiles by risk-adjusted complication rate further confirmed the presence of important variations in failure-to-rescue, indicating differences between hospitals in the risk of death among patients after they develop complications.Conclusions.Comparison of failure-to-rescue rates across health care systems suggests the presence of preventable postoperative deaths. Using such metrics, developing nations could benefit from a data-driven approach to quality improvement, which has proved effective in high-income countries.
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- 2017
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25. Patient satisfaction with childbirth after external cephalic version
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Bogner, G, Hammer, B E, Schausberger, C, Fischer, T, Reisenberger, K, and Jacobs, V
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- 2014
26. Trebananib or placebo plus carboplatin and paclitaxel as first-line treatment for advanced ovarian cancer (TRINOVA-3/ENGOT-ov2/GOG-3001): a randomised, double-blind, phase 3 trial
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Vergote, I. Scambia, G. O'Malley, D.M. Van Calster, B. Park, S.-Y. del Campo, J.M. Meier, W. Bamias, A. Colombo, N. Wenham, R.M. Covens, A. Marth, C. Raza Mirza, M. Kroep, J.R. Ma, H. Pickett, C.A. Monk, B.J. Park, S.Y. Song, Y.S. Makarova, Y. Trinidad, J. Ngan, H.Y.S. Aravantinos, G. Nam, J.-H. Gorbunova, V. Krikunova, L. Bae, D.-S. Arija, J.A.A. Mirza, M.R. Zamagni, C. Papandreou, C. Raspagliesi, F. Lisyanskaya, A. Benzaquen, A.O. Tognon, G. Ortega, E. Herraez, A.C. Buscema, J. Green, A. Burger, R. Sakaeva, D. Sanchez, A.R. Ghamande, S. King, L. Petru, E. Peen, U. Takeuchi, S. Ushijima, K. Martin, A.G. Kamelle, S. Carney, M. Forget, F. Bentley, J. Sehouli, J. Zola, P. Kato, H. Fadeeva, N. Gotovkin, E. Vladimirov, V. Marin, M.R. Alia, E.G. Shahin, M. Bhoola, S. Tewari, K. Anderson, D. Honhon, B. Pelgrims, J.G. Oza, A. Jimenez, J.G.-D. Hansen, V. Benjamin, I. Renard, V. Van den Bulck, H. Haenle, C. Koumakis, G. Yokota, H. Popov, V. Bradley, W. Wenham, R. Reid, R. McNamara, D. Friedman, R. Barlin, J. Spirtos, N. Chapman, J. Sevelda, P. Huizing, M. Lamot, C. Goffin, F. Hondt, L.D. Covens, A. Spadafora, S. Rautenberg, B. Reimer, T. Möbus, V. Hilpert, F. Gropp-Meier, M. Savarese, A. Pignata, S. Verderame, F. Mizuno, M. Takano, H. Ottevanger, P. Velasco, A.P. Palacio-Vazquez, I. Law, A. McIntyre, K. Teneriello, M. Fields, A. Lentz, S. Street, D. Schwartz, B. Mannel, R. Lim, P. Pulaski, H. Janni, W. Zorr, A. Karck, U. Cheng, A.C.K. Sorio, R. Gridelli, C. Aoki, D. Oishi, T. Hirashima, Y. Boere, I. Ferrer, E.F. Braly, P. Wilks, S. Lee, C. Schilder, J. Veljovich, D. Secord, A. Davis, K. Rojas-Espaillat, L. Lele, S. DePasquale, S. Squatrito, R. Schauer, C. Dirix, L. Vuylsteke, P. Joosens, E. Provencher, D. Lueck, H.-J. Hein, A. Burges, A. Canzler, U. Park-Simon, T.-W. Griesinger, F. Gadducci, A. Alabiso, O. Okamoto, A. Sawasaki, T. Saito, T. Ibañez, A.H. Calomeni, C. Spillman, M. Choksi, J. Taylor, N. Muller, C. Moore, D. DiSilvestro, P. Cunningham, M. Rose, P. Oppelt, P. Verhoeven, D. Graas, M.-P. Ghatage, P. Tonkin, K. Kurzeder, C. Schnappauf, B. Müller, V. Schmalzrie, H. Kalofonos, H. Bruzzone, M. Kroep, J. Diaz, C.C. Garcia, J.M. Polo, S.H. Garrison, M. Rocconi, R. Andrews, S. Bristow, R. McHale, M. Basil, J. Houck III, W. Bell, M. Cosin, J. Modesitt, S. Kendrick, J. Wade III, J. Wong, C. Evans, A. Buekers, T. Vanderkwaak, T. Ferriss, J. Darus, C. DAndre, S. Higgins, R. Monk, B. Bakkum-Gamez, J. DeMars, L. Van Le, L. Puls, L. Trehan, S. LaPolla, J. Michelson, E.D. Merchant, J. Peterson, C. Reid, G. Seago, D. Zweizig, S. Gajewski, W. Panwalkar, A. Leikermoser, R. Bogner, G. Debruyne, P. D'hondt, R. Berteloot, P. Kerger, J. Biagi, J. Castonguay, V. Welch, S. Muhic, A. Heubner, M. Grischke, E.-M. Rack, B. Fleisch, M. Lordick, F. Pectasides, D. Ho, W.M. Selvaggi, L. Vasquez, F.M. Villanueva, W.O.B. Alavez, A.M. Kessels, L. Bertran, A.S. Fernandez, C.M. Fabregat, M.B. Del Prete, S. Elkas, J. Cecchi, G. Kumar, P. Huh, W. Messing, M. Karimi, M. Kelley, A. Edraki, B. Mutch, D. Leiserowitz, G. Anderson, J. Lentz, S. Chambers, S. Morris, R. Waggoner, S. Gordon, A. Method, M. Johnson, P. Lord, R. Drake, J. Sivarajan, K. Midathada, M. Rice, K. Wadsworth, T. Pavelka, J. Edwards, R. Miller, D.S. Ford, P.L. Hurteau, J. Bender, D. Schimp, V. Creasman, W. Lerner, R. Chamberlain, D. Kueck, A. McDonald, J. Malad, S. Robinson-Bennett, B. Davidson, S. Krivak, T. Lestingi, T. Arango, H. Berard, P. Finkelstein, K. Gaur, R. Krasner, C. Ueland, F. Talmage, L. Yamada, S. Sutton, G. Potkul, R. Prasad-Hayes, M. Osborne, J. Celano, P. Thigpen, J. Sharma, S. Schilder, R. Tammela, J. Kemeny, M. Brown, A. Eisenhauer, E. Williams, J. Rowland, K. Nahum, K. Burke, J. Dar, Z. Fleming, N. Gibb, R. Guirguis, A. Herzog, T. John, V. Kumar, S. Kamat, A. Kassar, M. Leitao, M. Levine, L. Mendez, L. Patel, D. Berry, E. Warshal, D. Wolf, J. Zarwan, C. Collins, Y. Spitzer, G. Miller, B. Einstein, M. TRINOVA-3/ENGOT-ov2/GOG-3001 investigators
- Abstract
Background: Angiopoietin 1 and 2 regulate angiogenesis and vascular remodelling by interacting with the tyrosine kinase receptor Tie2, and inhibition of angiogenesis has shown promise in the treatment of ovarian cancer. We aimed to assess whether trebananib, a peptibody that inhibits binding of angiopoietin 1 and 2 to Tie2, improved progression-free survival when added to carboplatin and paclitaxel as first-line therapy in advanced epithelial ovarian, primary fallopian tube, or peritoneal cancer in a phase 3 clinical trial. Methods: TRINOVA-3, a multicentre, multinational, phase 3, double-blind study, was done at 206 investigational sites (hospitals and cancer centres)in 14 countries. Eligible patients were aged 18 years or older with biopsy-confirmed International Federation of Gynecology and Obstetrics (FIGO)stage III to IV epithelial ovarian, primary peritoneal, or fallopian tube cancers, and an ECOG performance status of 0 or 1. Eligible patients were randomly assigned (2:1)using a permuted block method (block size of six patients)to receive six cycles of paclitaxel (175 mg/m2)and carboplatin (area under the serum concentration-time curve 5 or 6)every 3 weeks, plus weekly intravenous trebananib 15 mg/kg or placebo. Maintenance therapy with trebananib or placebo continued for up to 18 additional months. The primary endpoint was progression-free survival, as assessed by the investigators, in the intention-to-treat population. Safety analyses included patients who received at least one dose of study treatment. This trial is registered with ClinicalTrials.gov, number NCT01493505, and is complete. Findings: Between Jan 30, 2012, and Feb 25, 2014, 1164 patients were screened and 1015 eligible patients were randomly allocated to treatment (678 to trebananib and 337 to placebo). After a median follow-up of 27·4 months (IQR 17·7–34·2), 626 patients had progression-free survival events (405 [60%]of 678 in the trebananib group and 221 [66%]of 337 in the placebo group). Median progression-free survival did not differ between the trebananib group (15·9 months [15·0–17·6])and the placebo group (15·0 months [12·6–16·1])groups (hazard ratio 0·93 [95% CI 0·79–1·09]; p=0·36). 512 (76%)of 675 patients in the trebananib group and 237 (71%)of 336 in the placebo group had grade 3 or worse treatment-emergent adverse events; of which the most common events were neutropenia (trebananib 238 [35%]vs placebo 126 [38%])anaemia (76 [11%]vs 40 [12%]), and leucopenia (81 [12%]vs 35 [10%]). 269 (40%)patients in the trebananib group and 104 (31%)in the placebo group had serious adverse events. Two fatal adverse events in the trebananib group were considered related to trebananib, paclitaxel, and carboplatin (lung infection and neutropenic colitis); two were considered to be related to paclitaxel and carboplatin (general physical health deterioration and platelet count decreased). No treatment-related fatal adverse events occurred in the placebo group. Interpretation: Trebananib plus carboplatin and paclitaxel did not improve progression-free survival as first-line treatment for advanced ovarian cancer. The combination of trebananib plus carboplatin and paclitaxel did not produce new safety signals. These results show that trebananib in combination with carboplatin and paclitaxel is minimally effective in this patient population. Funding: Amgen. © 2019 Elsevier Ltd
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- 2019
27. First trimester three-dimensional ultrasound volumetry of the gestational sac
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Steinen, H., Gregg, A. R., Bogner, G., Graf, A. H., Weiner, C. P., and Staudach, A.
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- 1994
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28. External cephalic version and reducing the incidence of term breech presentation
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Impey, L, Murphy, D, Griffiths, M, Bray, E, Penna, L, Aggarwal, A, Akaba, G, Barrett, J, Bogner, G, Danielian, P, De Hundt, M, Diyaf, A, El-Sayed, Y, Fernando, R, Gillham, J, Hemelaar, J, Hinshaw, H, Kumar, B, Leung, T, McGregor, E, Paterson-Brown, S, Robinson, S, Say, R, Sentilhes, L, Sheridan, M, Sung, H, Vlemmix, F, Weiniger, C, Gupta, M, Sarkar, P, Owen, P, and Thomson, A
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- 2018
29. P39 ITIC2 trial – topical imiquimod versus conization to treat cervical intraepithelial neoplasia: randomised controlled, non-inferiority trial
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Polterauer, S, primary, Reich, O, additional, Widschwendter, A, additional, Ganhoer-Schimboeck, J, additional, Bogner, G, additional, Berger, R, additional, Horvat, R, additional, Gleiss, A, additional, Fraunschiel, M, additional, Aberle, S, additional, Reinthaller, A, additional, Grimm, C, additional, and Austria, AGO, additional
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- 2019
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30. Phase III PAOLA-1/ENGOT-ov25 trial: olaparib plus bevacizumab as maintenance therapy in patients with newly diagnosed, advanced ovarian cancer treated with platinum-based chemotherapy plus bevacizumab
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Harter, P, primary, Mouret-Reynier, MA, additional, Pignata, S, additional, Cropet, C, additional, González-Martin, A, additional, Bogner, G, additional, Fujiwara, K, additional, Vergote, I, additional, Colombo, N, additional, Mäenpää, J, additional, Floquet, A, additional, El-Balat, A, additional, Lorusso, D, additional, Guerra Alia, EM, additional, Fabbro, M, additional, Schmalfeldt, B, additional, Hardy Blessard, AC, additional, Runnebaum, I, additional, Pujade-Lauraine, E, additional, and Ray-Coquard, I, additional
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- 2019
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31. EP15.24: Regular lung development in a singleton pregnancy with bilateral renal agenesis
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Huber‐Katamay, J., primary, Gruber, R., additional, Bogner, G., additional, Brandner, J., additional, Fischer, T., additional, and Fazelnia, C., additional
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- 2019
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32. Geburtsassoziierte Komplikationen bei Niedrig-Risiko-Schwangerschaften
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Hinterreitner, F, additional and Bogner, G, additional
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- 2019
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33. Normale Lungenentwicklung einer Einlingsgravidität trotz bilateraler Nierenagenesie
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Huber-Katamay, J, additional, Gruber, R, additional, Bogner, G, additional, Brandner, J, additional, Fischer, T, additional, and Fazelnia, C, additional
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- 2019
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34. In-hospital clinical outcomes after upper gastrointestinal surgery: Data from an international observational study
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Anesthesiology, ACS - Diabetes & metabolism, ACS - Microcirculation, ACS - Amsterdam Cardiovascular Sciences, APH - Quality of Care, ACS - Heart failure & arrhythmias, and International Surgical Outcomes Study (ISOS) group
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Male ,IMPACT ,Cancer ,Complication rate ,Mortality ,Oesophagectomy ,Postoperative care ,Upper gastrointestinal surgery ,SURGICAL COMPLICATIONS ,0302 clinical medicine ,Postoperative Complications ,Risk Factors ,Outcome Assessment, Health Care ,030212 general & internal medicine ,Hospital Mortality ,Prospective Studies ,ESOPHAGOGASTRIC CANCER ,Prospective cohort study ,Digestive System Surgical Procedures ,RISK ,Perioperative medicine ,General Medicine ,Middle Aged ,Oncology ,Length of Stay/statistics & numerical data ,Elective Surgical Procedures ,MORTALITY FOLLOWING ESOPHAGECTOMY ,030220 oncology & carcinogenesis ,Female ,Elective Surgical Procedure ,Cohort study ,medicine.medical_specialty ,ENHANCED RECOVERY ,PERIOPERATIVE MEDICINE ,Postoperative Complications/mortality ,NO ,03 medical and health sciences ,Outcome Assessment (Health Care) ,MORBIDITY ,medicine ,Humans ,Digestive System Surgical Procedures/mortality ,business.industry ,LONG-TERM SURVIVAL ,Odds ratio ,Length of Stay ,CARE ,medicine.disease ,Confidence interval ,Surgery ,Human medicine ,Complication ,business - Abstract
Aims: Previous research suggests that patients undergoing upper gastrointestinal surgery are at high risk of poor postoperative outcomes. The aim of our study was to describe patient outcomes after elective upper gastrointestinal surgery at a global level.Methods: Prospective analysis of data collected during an international seven-day cohort study of 474 hospitals in 27 countries. Patients undergoing elective upper gastrointestinal. surgery were recruited. Outcome measures were in-hospital complications and mortality at 30-days. Results are presented as n(%) and odds ratios with 95% confidence intervals.Results: 2139 patients were included, of whom 498 (23.2%) developed one or more postoperative complications, with 30 deaths (1.4%). Patients with complications had longer median hospital stay 11 (6-18) days vs. 5 (2-10) days. Infectious complications were most frequent, affecting 368 (17.2%) patients. 328 (15.3%) patients were admitted to critical care postoperatively, of whom 161 (49.1%) developed a complication with 14 deaths (4.3%). In a multivariable logistic regression model we identified age (OR 1.02 [1.01-1.03]), American Society of Anesthesiologists physical status III (OR 2.12 [1.44-3.16]) and IV (OR 3.23 [1.72-6.09]), surgery for cancer (OR 1.63 [1.27-2.11]), open procedure (OR 1.40 [1.10-1.78]), intermediate surgery (OR 1.75 [1.12-2.81]) and major surgery (OR 2.65 [1.72-4.23]) as independent risk factors for postoperative complications. Patients undergoing major surgery for upper gastrointestinal cancer experienced twice the rate of complications compared to those undergoing other procedures (224/578 patients [38.8%] versus 274/1561 patients [17.6%]).Conclusions: Complications and death are common after upper gastrointestinal surgery. Patients undergoing major surgery for cancer are at greatest risk. (C) 2017 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
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- 2017
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35. External Cephalic Version and Reducing the Incidence of Term Breech Presentation
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Impey, L. W. M., Murphy, D. J., Griffiths, M., Bray, Eaton, Penna, L. K., Aggarwal, A., Akaba, G., Barrett, J. F. R., Bogner, G., Danielian, P. J., de Hundt, M., Diyaf, A., El-Sayed, Y., Fernando, R., Gillham, J. C., Hemelaar, J., Hinshaw, H. K. S., Kumar, B., Leung, T. Y., McGregor, E. G., Paterson-Brown, S., Robinson, S., Say, R. E., Sentilhes, L., Sheridan, M., Sung, H. P., Vlemmix, F., Weiniger, C. F., Gupta, M., Sarkar, P., Owen, P., Thomson, A. J., ARD - Amsterdam Reproduction and Development, and Obstetrics and Gynaecology
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36. Reviews of Large Superconducting Machines
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Bogner, G., Foner, Simon, editor, and Schwartz, Brian B., editor
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37. Large-Scale Applications of Superconductivity
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Bogner, G., Schwartz, Brian B., editor, and Foner, Simon, editor
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38. Transmission of Electrical Energy by Superconducting Cables
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Bogner, G., Foner, Simon, editor, and Schwartz, Brian B., editor
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- 1974
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39. Programs on Large Scale Applications of Superconductivity in the Federal Republic of Germany
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Bogner, G., Foner, Simon, editor, and Schwartz, Brian B., editor
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- 1974
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40. Present and Future Application of Nonmetallic Materials in Cryogenic Technology: Summary of the Panel Discussion
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Bogner, G., Hartwig, Günther, editor, and Evans, David, editor
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41. Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries
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Carolyn, Panckhurst, Jonathan, Sara, Rachel, Stapelberg, Francoi, Campbell, Doug, Cherrett, Veronica, Ganter, Donna Louise, Mccann, Lloyd, Gilmour, Fiona, Lumsden, Rachelle, Moores, Mark, Olliff, Sue, Sardareva, Elitza, Tai, Joyce, Wikner, Matthew, Wong, Christopher, Chaddock, Mark, Czepanski, Carolyn, Mckendry, Patrick, Polakovic, Daniel, Polakovich, Daniel, Robert, Axe, Belda, Margarita Tormo, Norton, Tracy, Alherz, Fadhel, Barneto, Lisa, Ramirez, Alberto, Sayeed, Ahmed, Smith, Nicola, Bennett, Cambell, Mcquoid, Shane, Jansen, Tracy-Lee, Nico, Zin, Scott, John, Freschini, David, Freschini, Angela, Hopkins, Brian, Manson, Lara, Stoltz, Deon, Bates, Alexander, Davis, Simon, Freeman, Victoria, Mcgaughran, Lynette, Williams, Maya, Sharma, Swarna Baskar, Burrows, Tom, Byrne, Kelly, English, Duane, Johnson, Robert, Manikkam, Brendon, Naidoo, Shaun, Rumball, Margot, Whittle, Nicola, Franks, Romilla, Gibson-Lapsley, Hannah, Salter, Ryan, Walsh, Dean, Cooper, Richard, Perry, Katherine, 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Clementina Oana, Jemna, Ramona, Mihaescu, Florentina, Petre, Raluca, Tudor, Cristina, Ursache, Elena, Kulikov, Alexander, Lubnin, Andrey, Grigoryev, Evgeny, Pugachev, Stanislav, Protsenko, Deni, Tolmasov, Alexander, Hussain, Ayyaz, Ilyina, Yana, Kirov, Mikhail, Roshchina, Anna, Iurin, Aleksandr, Chazova, Elena, Dunay, Artem, Karelov, Alexey, Khvedelidze, Irina, Voldaeva, Olga, Belskiy, Vladislav, Dzhamullaev, Parvin, Grishkowez, Elena, Kretov, Vladimir, Levin, Valeriy, Molkov, Aleksandr, Puzanov, Sergey, Samoilenko, Aleksandr, Tchekulaev, Aleksandr, Tulupova, Valentina, Utkin, Ivan, Allorto, Nikki Leigh, Bishop, David Gray, Builu, Pierre Monji, Cairns, Carel, Dasrath, Ashish, De Wet, Jacque, Den Hoedt, Marielle, Grey, Ben, Hayes, Morgan Philip, Kã¼sel, Belinda Senta, Shangase, Nomcebo, Wise, Robert, Cacala, Sharon, Farina, Zane, Govindasamy, Vishendran, Kruse, Carl-Heinz, Lee, Carolyn, Marais, Leonard, Naidoo, Thinagrin Dhasarthun, Rajah, Chantal, Rodseth, Reitze Nil, Ryan, Lisa, Von 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T., Loots, Emil, Madansein, Rajhmum, Madaree, Anil, Madiba, Thandinkosi E., Manzini, Vukani T., Mbuyisa, Mbali, Moodley, Rajan, Msomi, Mduduzi, Mukama, Innocent, Naidoo, Desigan, Naidoo, Rubeshan, Naidu, Tesuven K., Ntloko, Sindiswa, Padayachee, Eneshia, Padayachee, Lucelle, Phaff, Martijn, Pillay, Bala, Pillay, Desigan, Pillay, Lutchmee, Ramnarain, Anupa, Ramphal, Suren R., Ryan, Paul, Saloojee, Ahmed, Sebitloane, Motshedisi, Sigcu, Noluyolo, Taylor, Jenna L., Torborg, Alexandra, Visser, Linda, Anderson, Philip, Conradie, Alae, De Swardt, Mathew, De Villiers, Martin, Eikman, Johan, Liebenberg, Riaan, Mouton, Johan, Paton, Abbey, Van Der Merwe, Louwrence, Wilscott-Davids, Candice, Barrett, Wendy Joan, Bester, Marlet, De Beer, Johan, Geldenhuys, Jacque, Gouws, Hanni, Potgieter, Jan-Hendrik, Strydom, Magdel, Wilberforceturton, Edwin, Chetty, Rubendraj R., Chirkut, Subash, Cronje, Larissa, De Vasconcellos, Kim, Dube, Nokukhanya Z., Gama, N. 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Denham, Samuel, Griffiths, Ewen, Peter, Ip, Jeyanthan, Somasundaram, Joory, Kavita, Kaur, Satwant, Marriott, Paul, Mitchell, Natalie, Nagaiah, Sukumar, Nilsson, Annette, Parekh, Nilesh, Pope, Martin, Seager, Joseph, Serag, Hosam, Tameem, Alifia, Thomas, Anna, Thunder, Joanne, Torrance, Andrew, Vohra, Ravinder, Whitehouse, Arlo, Wong, Tony, Blunt, Mark, Wong, Kate, Giles, Julian, Reed, Isabelle, Weller, Debbie, Bell, Gillian, Birch, Julie, Damant, Rose, Maiden, Jane, Mewies, Clare, Prince, Claire, Radford, Jane, Reynolds, Tim, Balain, Birender, Banerjee, Robin, Barnett, Andrew, Burston, Ben, Davies, Kirsty, Edwards, Jayne, Evans, Chri, Ford, David, Gallacher, Pete, Hill, Simon, Jaffray, David, Karlakki, Sudheer, Kelly, Cormac, Kennedy, Julia, Kiely, Nigel, Lewthwaite, Simon, Marquis, Chri, Ockendon, Matthew, Phillips, Stephen, Pickard, Simon, Richardson, Jame, Roach, Richard, Smith, Tony, Spencer-Jones, Richard, Steele, Niall, Steen, Julie, Van Liefland, Marck, White, Steve, Faulds, Matthew, Harris, Meredyth, Kelly, Carrie, Nicol, Scott, Pearson, Sally Anne, Chukkambotla, Srikanth, Andrew, Alyson, Attrill, Elizabeth, Campbell, Graham, Datson, Amanda, Fouracres, Anna, Graterol, Juan, Graves, Lynne, Hong, Bosun, Ishimaru, Alexander, Karthikeyan, Arvind, King, Helen, Lawson, Tom, Lee, Gregory, Lyons, Saoirse, Hall, Andrew Macalister, Mathoulin, Sophie, Mcintyre, Eilidh, Mclaughlin, Danny, Mulcahy, Kathleen, Paddle, Jonathan, Ratcliffe, Anna, Robbins, Jame, Sung, Weilin, Tayo, Adeoluwa, Trembath, Lisa, Venugopal, Suneetha, Walker, Robert, Wigmore, Geoffrey, Boereboom, Catherine, Downes, Charlotte, Humphries, Ryan, Melbourne, Susan, Smith, Coral, Tou, Samson, Ullah, Shafa, Batchelor, Nick, Boxall, Leigh, Broomby, Rupert, Deen, Tariq, Hellewell, Alistair, Helliwell, Laurence, Hutchings, Melanie, Hutchins, David, Keenan, Samantha, Mackie, Donna, Potter, Alison, Smith, France, Stone, Lucy, Thorpe, Kevin, Wassall, Richard, Woodgate, Andrew, Baillie, Shelley, Campbell, Tara, James, Sarah, King, Chri, De Araujo, Daniela Marque, Martin, Danial, Morkane, Clare, Neely, Julia, Rajendram, Rajkumar, Burton, Megan, James, Kathryn, Keevil, Edward, Minik, Orsolya, Morgan, Jenna, Musgrave, Anna, Rajanna, Harish, Roberts, Tracey, Szakmany, Tama, Adamson, Michael, Jumbe, Sandra, Kendall, Jennie, Muthuswamy, Mohan Babu, Anderson, Charlotte, Cruikshanks, Andrew, Wrench, Ian, Zeidan, Lisa, Ardern, Diane, Harris, Benjamin, Hellstrom, Johanna, Martin, Jane, Thomas, Richard, Varsani, Nimu, Brown, Caroline Wrey, Docherty, Philip, Gillies, Michael, Mcgregor, Euan, Usher, Helen, Craig, Jayne, Smith, Andrew, Ahmad, Tahania, Bodger, Phoebe, Creary, Thai, Everingham, Kirsty, Fowler, Alexander, Hewson, Russell, Ijuo, Eke, Januszewska, Marta, Jones, Timothy, Kantsedikas, Ilya, Lahiri, Sumitra, Mclean, Aaron Lawson, Niebrzegowska, Edyta, Phull, Mandeep-Kaur, Wang, Difei, Wickboldt, Nadine, Baldwin, Jacqueline, Doyle, Donna, Mcmullan, Sean, Oladapo, Michelle, Owen, Thoma, Williams, Alexandra, Daniel, Hull, Gregory, Peter, Husain, Tauqeer, Kirk-Bayley, Justin, Mathers, Edward, Montague, Laura, Harper, Mark, White, Stuart, Jack, Jame, Ridley, Carrie, Avis, Joanne, Cook, Tim, Dali-Kemmery, Lola, Kerslake, Ian, Lambourne, Victoria, Pearson, Annabel, Boyd, Christine, Callaghan, Mark, Lawson, Cathy, Mccrossan, Roopa, Nesbitt, Vanessa, O'Connor, Laura, Scott, Julia, Sinclair, Rhona, Farid, Nahla, Morgese, Ciro, Bhatia, Kailash, Karmarkar, Swati, Ahmed, Jamil, Branagan, Graham, Hutton, Monica, Swain, Andrew, Brookes, Jamie, Cornell, Jonathan, Dolan, Rachael, Hulme, Jonathan, Van Vuuren, Amanda Jansen, Jowitt, Tom, Kalashetty, Gunasheela, Lloyd, Fran, Patel, Kiran, Sherwood, Nichola, Brown, Lynne, Chandler, Ben, Deighton, Kerry, Emma, Temlett, Haunch, Kirsty, Cheeseman, Michelle, Dent, Kathy, Garg, Sanjeev, Gray, Carol, Hood, Marion, Jones, Dawn, Juj, Joanne, Rao, Roshan, Walker, Tara, Al Anizi, Mashel, Cheah, Clarissa, Cheing, Yushio, Coutinho, Francisco, Gondo, Prisca, Hadebe, Bernard, Hove, Mazvangu Onie, Khader, Ahamed, Krishnachetty, Bobby, Rhodes, Karen, Sokhi, Jagdish, Baker, Katie-Anne, Bertram, Wendy, Looseley, Alex, Mouton, Ronelle, Hanna, George, Arnold, Glenn, Arya, Shobhit, Balfoussia, Danai, Baxter, Linden, Harris, Jame, Jones, Craig, Knaggs, Alison, Markar, Sheraz, Perera, Anisha, Scott, Alasdair, Shida, Asako, Sirha, Ravneet, Wright, Sally, Frost, Victoria, Gray, Catherine, Andrews, Emma, Arrandale, Lindsay, Barrett, Stephen, Cifra, Elna, Cooper, Mariese, Dragnea, Drago, Elna, Cifra, Maclean, Jennifer, Meier, Sonja, Milliken, Donald, Munns, Christopher, Ratanshi, Nadir, Ramessur, Suneil, Salvana, Abegail, Watson, Anthony, Hani, Ali, Campbell, Gill, Critchley, Rebecca, Endersby, Simon, Hicks, Catherine, Liddle, Alison, Pass, Marc, Ritchie, Charlotte, Thomas, Charlotte, Too, Lingxi, Welsh, Sarah, Gill, Talvinder, Johnson, Joanne, Reed, Joanne, Davis, Edward, Papadopoullos, Sam, Attwood, Clare, Biffen, Andrew, Boulton, Kerenza, Gray, Sophie, Hay, David, Mills, Sarah, Montgomery, Jane, Riddell, Rory, Simpson, Jame, Bhardwaj, Neeraj, Paul, Elaine, Uwubamwen, Nosakhare, Alexander, Maini, Arrich, Jame, Arumugam, Swarna, Blackwood, Dougla, Boggiano, Victoria, Brown, Robyn, Chan, Yik Lam, Chatterjee, Devnandan, Chhabra, Ashok, Christian, Rachel, Costelloe, Hannah, Matthewman, Madeline Coxwell, Dalton, Emma, Darko, Julia, Davari, Maria, Dave, Tejal, Deacon, Matthew, Deepak, Shantal, Edmond, Holly, Ellis, Jessica, El-Sayed, Ahmed, Eneje, Philip, English, Rose, Ewe, Renee, Foers, William, Franklin, John, Gallego, Laura, Garrett, Emily, Goldberg, Olivia, Goss, Harry, Greaves, Rosanna, Harris, Rudy, Hennings, Charle, Jones, Eleanor, Kamali, Nelson, Kokkinos, Naomi, Lewis, Cary, Lignos, Leda, Malgapo, Evaleen Victoria, Malik, Rizwana, Milne, Andrew, Mulligan, John-Patrick, Nicklin, Philippa, Palipane, Natasha, Parsons, Thoma, Piper, Rebecca, Prakash, Rohan, Ramesh, Byron, Rasip, Sarah, Reading, Jacob, Rela, Mariam, Reyes, Anna, Robert, Stephen, Rooms, Martin, Shah, Karishma, Simons, Henry, Solanki, Shalil, Spowart, Emma, Stevens, Amy, Thomas, Christopher, Waggett, Helena, Yassaee, Arrash, Kennedy, Anthony, Scott, Sara, Somanath, Sameer, Berg, Andrew, Miguel, Hernandez, Nanda, Rajesh, Tank, Ghanshyambhai, Wilson, Natalie, Wilson, Debbie, Al-Soudaine, Yassr, Baldwin, Matthew, Cornish, Julie, Davies, Zoe, Davies, Leigh, Edwards, Marc, Frewer, Natasha, Gallard, Sian, Glasbey, Jame, Harries, Rhiannon, Hopkins, Luke, Kim, Taeyang, Koompirochana, Vilavan, Lawson, Simon, Lewis, Megan, Makzal, Zaid, Scourfield, Sarah, Ahmad, Yousra, Bates, Sarah, Blackwell, Clare, Bryant, Helen, Collins, Hannah, Coulter, Suzanne, Cruickshank, Ro, Daniel, Sonya, Daubeny, Thoma, Edwards, Mark, Golder, Kim, Hawkins, Lesley, Helen, Bryant, Hinxman, Honor, Levett, Denny, Salmon, Karen, Seaward, Leanne, Skinner, Ben, Tyrell, Bryony, Wadams, Beverley, Walsgrove, Joseph, Dickson, Jane, Constantin, Kathryn, Karen, Markwell, O'Brien, Peter, O'Donohoe, Lynn, Payne, Hannah, Sundayi, Saul, Walker, Elaine, Brooke, Jenny, Cardy, Jon, Humphreys, Sally, Kessack, Laura, Kubitzek, Christiane, Kumar, Suha, Cotterill, Donna, Hodzovic, Emil, Hosdurga, Gurunath, Miles, Edward, Saunders, Glenn, Campbell, Marta, Chan, Peter, Jemmett, Kim, Raj, Ashok, Naik, Aditi, Oshowo, Ayo, Ramamoorthy, Rajarajan, Shah, Nimesh, Sylvan, Axel, Blyth, Katharine, Burtenshaw, Andrew, Freeman, David, Johnson, Emily, Philip, Lo, Martin, Terry, Plunkett, Emma, Wollaston, Julie, Allison, Joanna, Carroll, Christine, Craw, Nichola, Craw, Sarah, Pitt-Kerby, Tressy, Rowland-Axe, Rebecca, Spurdle, Katie, Mcdonald, Andrew, Simon, Davie, Sinha, Vivek, Smith, Thoma, Banner-Goodspeed, Valerie, Boone, Myle, Campbell, Kathleen, Fengxin, Lu, Scannell, Joseph, Sobol, Julia, Balajonda, Naraida, Clemmons, Karen, Conde, Carlo, Elgasim, Magdi, Funk, Bonita, Hall, Roger, Hopkins, Thoma, Olaleye, Omowunmi, Omer, Omer, Pender, Michelle, Porto, Angelo, Stevens, Alice, Waweru, Peter, Yeh, Erlinda, Bodansky, Daniella, Evans, Adam, Kleopoulos, Steven, Maril, Robert, Mathney, Edward, Sanchez, Angela, Tinuoye, Elizabeth, Bateman, Brian, Eng, Kristen, Jiang, Ning, Ladha, Karim, Needleman, Joseph, Chen, Lee-Lynn, Lane, Rondall, Robinowitz, David, Ghushe, Neil, Irshad, Mariam, O'Connor, John, Patel, Samir, Myles, Paul, Hiesmayr, Michael, Fang, Xiangming, Slim, Karem, Sander, Michael, Koulenti, Despoina, Chan, Mathew, Abbas, Muntadhar, Sivasakthi, Datin, Osinaike, Tunde, Matos, Ricardo, Grigoras, Ioana, Hubner, Martyn, Other departments, The International Surgical Outcomes Study, Group, Beretta, L, Landoni, G, and Zangrillo, A
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Critical Care/utilization ,Postoperative Complications/epidemiology ,Male ,cohort studies, critical care/utilisation, operative/mortality, postoperative care/methods, postoperative care/statistics and numerical data, surgery, surgical procedures ,Global Health ,law.invention ,surgery ,Postoperative Complications ,0302 clinical medicine ,Correction Notice ,cohort studies ,Anesthesiology ,030202 anesthesiology ,law ,cohort studiescritical care/utilisationoperative/mortalitypostoperative care/methodspostoperative care/statistics and numerical datasurgerysurgical procedures ,80 and over ,Hospital Mortality ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Aged, 80 and over ,International Surgical Outcomes Study group ,Elective Surgical Procedures/mortality ,HCC NEF ,Middle Aged ,Elective Surgical Procedures/adverse effects ,Intensive care unit ,surgical procedure ,3. Good health ,Treatment Outcome ,Length of Stay/statistics & numerical data ,operative/mortality ,Elective Surgical Procedures ,Female ,Elective Surgical Procedure ,Life Sciences & Biomedicine ,Cohort study ,Adult ,medicine.medical_specialty ,Adolescent ,Critical Care ,critical care/utilisation ,postoperative care/methods ,postoperative care/statistics and numerical data ,surgical procedures ,Aged ,Humans ,Length of Stay ,Poverty ,Socioeconomic Factors ,Young Adult ,Anesthesiology and Pain Medicine ,NO ,Clinical Practice ,03 medical and health sciences ,Intensive care ,Journal Article ,medicine ,postoperative care/method ,Elective surgery ,Science & Technology ,business.industry ,Postoperative complication ,030208 emergency & critical care medicine ,1103 Clinical Sciences ,Surgery ,Global Health/statistics & numerical data ,Emergency medicine ,business ,cohort studie - Abstract
Background:As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. Methods:We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. Results:A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44814 patients with a median hospital stay of 4 (range 2–7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. Conclusions:Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. Study registration:ISRCTN51817007
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- 2016
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42. Postpartal endomyometritis in a case of unknown tertian malaria
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Lechner, A., Bogner, G., and Hasenöhrl, G.
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- 1997
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43. Placental HPV infection – a potential risk factor for HELLP syndrome?
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Fazelnia, C, additional, Zellinger, B, additional, Gharehbaghi, D, additional, Kronberger, C, additional, Klein, B, additional, Bogner, G, additional, Hillerer, K, additional, Wertaschnigg, D, additional, and Fischer, T, additional
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- 2017
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44. Primäres diffus großzelliges B-Zell-Lymphom der Zervix in der Schwangerschaft – ein Fallbericht
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Gouy, C, primary, Fazelnia, C, additional, Wolfrum-Ristau, P, additional, Koch, H, additional, Mlineritsch, B, additional, Schönlieb, C, additional, Kronberger, C, additional, Bogner, G, additional, and Fischer, T, additional
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- 2016
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45. Zur Symptomatik der Coxarthrose
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Tilscher, H., Bogner, G., and Landsiedl, F.
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- 1976
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46. Energietransport durch tiefgekühlte Kabel
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Bogner, G. and Schmidt, F.
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- 1970
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47. Welchen Einfluss hat die Lage des II. Zwillings auf das perinatale Outcome?
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Bogner, G, primary, Wallner, V, additional, Resenberger, K, additional, and Fischer, T, additional
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- 2015
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48. Breech delivery of the second twin in all fours position of the mother
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Bogner, G, primary, Fazelnia, C, additional, Strobl, M, additional, Fischer, T, additional, and Jacobs, V, additional
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- 2015
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49. Effect of corticosteroid therapy in HELLP syndrome
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Gharehbaghi, D, primary, Fischer, T, additional, and Bogner, G, additional
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- 2015
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50. Intraoperative Strahlentherapie IORT bei Rezidiv eines Zervixkarzinoms nach prim./adjuvanter Radiotherapie
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Bogner, G, primary, Kaiser, J, additional, Kametriser, G, additional, Fischer, T, additional, and Sedlmayer, F, additional
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- 2015
- Full Text
- View/download PDF
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