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40 results on '"Bogar, K."'

1. Quantification of locked mode instability triggered by a change in confinement

Author

Peterka, M., Seidl, J., Markovic, T., Loarte, A., Logan, N. C., Park, J. -K., Cahyna, P., Havlicek, J., Imrisek, M., Kripner, L., Panek, R., Sos, M., Bilkova, P., Bogar, K., Bohm, P., Casolari, A., Gribov, Y., Grover, O., Hacek, P., Hron, M., Kovarik, K., Tomes, M., Tskhakaya, D., Varju, J., Vondracek, P., Weinzettl, V., and Team, the COMPASS

Subjects
Physics - Plasma Physics
Abstract

This work presents the first analysis of the disruptive locked mode (LM) triggered by the dynamics of a confinement change. It shows that, under certain conditions, the LM threshold during the transient is significantly lower than expected from steady states. We investigate the sensitivity to a controlled $n = 1$ error field (EF) activated prior to the L-H transition in the COMPASS tokamak, at $q_{95} \approx 3$, $\beta_N \approx 1$, and using EF coils on the high-field side of the vessel. A threshold for EF penetration subsequent to the L-H transition is identified, which shows no significant trend with density or applied torque, and is an apparent consequence of the reduced intrinsic rotation of the 2/1 mode during this transient phase. This finding challenges the assumption made in theoretical and empirical works that natural mode rotation can be predicted by global plasma parameters and urges against using any parametric EF penetration scaling derived from steady-state experiments to define the error field correction strategy in the entire discharge. Furthermore, even at EFs below the identified penetration threshold, disruptive locking of sawtooth-seeded 2/1 tearing modes is observed after about 30% of L-H transitions without external torque., Comment: 15 pages, 13 figures, submitted to Nuclear Fusion

Published
2024

2. Preliminary design of the COMPASS upgrade tokamak

Author

Vondracek, P., Panek, R., Hron, M., Havlicek, J., Weinzettl, V., Todd, T., Tskhakaya, D., Cunningham, G., Hacek, P., Hromadka, J., Junek, P., Krbec, J., Patel, N., Sestak, D., Varju, J., Adamek, J., Balazsova, M., Balner, V., Barton, P., Bielecki, J., Bilkova, P., Błocki, J., Bocian, D., Bogar, K., Bogar, O., Boocz, P., Borodkina, I., Brooks, A., Bohm, P., Burant, J., Casolari, A., Cavalier, J., Chappuis, P., Dejarnac, R., Dimitrova, M., Dudak, M., Duran, I., Ellis, R., Entler, S., Fang, J., Farnik, M., Ficker, O., Fridrich, D., Fukova, S., Gerardin, J., Hanak, I., Havranek, A., Herrmann, A., Horacek, J., Hronova, O., Imrisek, M., Isernia, N., Jaulmes, F., Jerab, M., Kindl, V., Komm, M., Kovarik, K., Kral, M., Kripner, L., Macusova, E., Majer, T., Markovic, T., Matveeva, E., Mikszuta-Michalik, K., Mohelnik, M., Mysiura, I., Naydenkova, D., Nemec, I., Ortwein, R., Patocka, K., Peterka, M., Podolnik, A., Prochazka, F., Prevratil, J., Reboun, J., Scalera, V., Scholz, M., Svoboda, J., Swierblewski, J., Sos, M., Tadros, M., Titus, P., Tomes, M., Torres, A., Tracz, G., Turjanica, P., Varavin, M., Veselovsky, V., Villone, F., Wąchal, P., Yanovskiy, V., Zadvitskiy, G., Zajac, J., Zak, A., Zaloga, D., Zelda, J., and Zhang, H.

Published
2021
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3. Diagnostic weight functions in constants-of-motion phase-space

Author

Rud, M., Moseev, D., Jaulmes, F., Bogar, K., Eriksson, Jacob, Järleblad, H., Nocente, M., Prechel, G., Reman, B. C. G., Schmidt, B. S., Snicker, A., Stagner, L., Valentini, A., Salewski, M., Rud, M., Moseev, D., Jaulmes, F., Bogar, K., Eriksson, Jacob, Järleblad, H., Nocente, M., Prechel, G., Reman, B. C. G., Schmidt, B. S., Snicker, A., Stagner, L., Valentini, A., and Salewski, M.

Abstract

The fast-ion phase-space distribution function in axisymmetric tokamak plasmas is completely described by the three constants of motion: energy, magnetic moment and toroidal canonical angular momentum. In this work, the observable regions of constants-of-motion phase-space, given a diagnostic setup, are identified and explained using projected velocities of the fast ions along the diagnostic lines-of-sight as a proxy for several fast-ion diagnostics, such as fast-ion D alpha spectroscopy, collective Thomson scattering, neutron emission spectroscopy and gamma-ray spectroscopy. The observable region in constants-of-motion space is given by a position condition and a velocity condition, and the diagnostic sensitivity is given by a gyro-orbit and a drift-orbit weighting. As a practical example, 3D orbit weight functions quantifying the diagnostic sensitivity to each point in phase-space are computed and investigated for the future COMPASS-Upgrade and MAST-Upgrade tokamaks.

Published
2024
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4. Orbit tomography in constants-of-motion phase-space

Author

Rud, M., Moseev, D., Jaulmes, F., Bogar, K., Dong, Y., Hansen, P. C., Eriksson, J., Järleblad, H., Nocente, M., Prechel, G., Reman, B. C.G., Schmidt, B., Snicker, A., Stagner, L., Valentini, A., Salewski, M., Rud, M., Moseev, D., Jaulmes, F., Bogar, K., Dong, Y., Hansen, P. C., Eriksson, J., Järleblad, H., Nocente, M., Prechel, G., Reman, B. C.G., Schmidt, B., Snicker, A., Stagner, L., Valentini, A., and Salewski, M.

Abstract

Tomographic reconstructions of a 3D fast-ion constants-of-motion phase-space distribution function are computed by inverting synthetic signals based on projected velocities of the fast ions along the diagnostic lines of sight. A spectrum of projected velocities is a key element of the spectrum formation in fast-ion D-alpha spectroscopy, collective Thomson scattering, and gamma-ray and neutron emission spectroscopy, and it can hence serve as a proxy for any of these. The fast-ion distribution functions are parameterised by three constants of motion, the kinetic energy, the magnetic moment and the toroidal canonical angular momentum. The reconstructions are computed using both zeroth-order and first-order Tikhonov regularisation expressed in terms of Bayesian inference to allow uncertainty quantification. In addition to this, a discontinuity appears to be present in the solution across the trapped-passing boundary surface in the three-dimensional phase space due to a singularity in the Jacobian of the transformation from position and velocity space to phase space. A method to allow for this apparent discontinuity while simultaneously penalising large gradients in the solution is demonstrated. Finally, we use our new methods to optimise the diagnostic performance of a set of six fans of sightlines by finding where the detectors contribute most complementary diagnostic information for the future COMPASS-Upgrade tokamak.

Published
2024

7. Determination of the background neutral density from passive Balmer alpha CX emission at the ASDEX Upgrade tokamak

Author

Van Vuuren, A, Bogar, K, Cruz-Zabala, D, Cavedon, M, Cano-Megias, P, Kappatou, A, Dux, R, Schneider, P, Viezzer, E, Nishizawa, T, Garcia-Munoz, M, Van Vuuren A. J., Bogar K., Cruz-Zabala D. J., Cavedon M., Cano-Megias P., Kappatou A., Dux R., Schneider P. A., Viezzer E., Nishizawa T., Garcia-Munoz M., Van Vuuren, A, Bogar, K, Cruz-Zabala, D, Cavedon, M, Cano-Megias, P, Kappatou, A, Dux, R, Schneider, P, Viezzer, E, Nishizawa, T, Garcia-Munoz, M, Van Vuuren A. J., Bogar K., Cruz-Zabala D. J., Cavedon M., Cano-Megias P., Kappatou A., Dux R., Schneider P. A., Viezzer E., Nishizawa T., and Garcia-Munoz M.

Published
2021

8. Experimental study of ELM induced fast-ion transport using passive FIDA spectroscopy at the ASDEX Upgrade tokamak

Author

Jansen Van Vuuren, A, Geiger, B, Schneider, P, Bogar, K, Poloskei, P, Cathey, A, Hoelzl, M, Jacobsen, A, Cavedon, M, Dux, R, Jansen Van Vuuren A., Geiger B., Schneider P. A., Bogar K., Poloskei P. Z., Cathey A., Hoelzl M., Jacobsen A. S., Cavedon M., Dux R., Jansen Van Vuuren, A, Geiger, B, Schneider, P, Bogar, K, Poloskei, P, Cathey, A, Hoelzl, M, Jacobsen, A, Cavedon, M, Dux, R, Jansen Van Vuuren A., Geiger B., Schneider P. A., Bogar K., Poloskei P. Z., Cathey A., Hoelzl M., Jacobsen A. S., Cavedon M., and Dux R.

Abstract

Measurements using a recently installed edge fast-ion D-alpha (FIDA) diagnostic at the ASDEX Upgrade tokamak show a clear effect of edge localised modes (ELMs) on the passive FIDA signals. While a reduction in the passive FIDA emission is observed in the scrape-off layer (SOL) region, measurements close to the last closed flux surface show an increase in signals shortly after ELMs, followed by a decrease. The decrease provides a clear sign of fast-ion losses in the SOL, while the increase can be explained by an enhanced neutral density during ELMs inside the plasma. In addition, small ELMs are observed, which barely change the neutral density and plasma position but still cause significant changes in the passive FIDA signals. A comparison of the measurements with forward modelling shows that 60% to 80% of the fast ions are lost by ELMs outside the last closed flux surface. In addition, a 20% decrease of the fast-ion density in a range up to 4 cm within the last closed flux surface can be inferred. This range agrees well with the latest modelling results of ELMs using the non-linear MHD code JOREK and shows that less than 0.3% of all fast ions are lost by ELMs.

Published
2021

9. Determination of the background neutral density from passive Balmer alpha CX emission at the ASDEX Upgrade tokamak

Author

Van Vuuren, A. J., Bogar, K., Cruz Zabala, Diego José, Cavedon, M., Cano Megías, Pilar, Kappatou, A., Dux, R., Schneider, P. A., Viezzer, Eleonora, Nishizawa, T., García Muñoz, Manuel, ASDEX Upgrade Team, Max Planck Institute for Plasma Physics, Max Planck Society, Van Vuuren, A, Bogar, K, Cruz-Zabala, D, Cavedon, M, Cano-Megias, P, Kappatou, A, Dux, R, Schneider, P, Viezzer, E, Nishizawa, T, Garcia-Munoz, M, Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Universidad de Sevilla. Departamento de Ingeniería Energética, and EUROfusion Consortium

Subjects
Plasma
Abstract

EUROfusion Consortium 633053

Published
2021

10. Numerical modelling for beam duct heat loads calculations and application to the new 1 MW neutral beam injector in the COMPASS tokamak.

Author

Jaulmes, F, Zadvitskiy, G, Bogar, K, Mysiura, I, Varju, J, Jeřáb, M, Komm, M, and Imrisek, M

Subjects
NEUTRAL beams, HEATING load, TOKAMAKS, FAST ions, INJECTORS, BEAM steering, MICROWAVE plasmas
Abstract

We introduce detailed numerical modelling of the fast neutral particles inside the duct of a new neutral beam injector (NBI) recently installed at the COMPASS tokamak (major radius R 0 = 0.56 m , vessel midplane minor radius a = 0.23 m , toroidal field B t = 0.9â€"2.1  T ). This new NBI system is able to deliver 1 M W power to the plasma at nominal injection energy of 80 k e V . Collisions with the background neutrals inside the beam duct give birth to fast ions according to the density of the gas and tabulated cross-sections. The ion trajectories are then computed in the complete 3D magnetic field, showing the importance of the stray magnetic field and the magnitude of the field within the gap in between toroidal coils.During the experimental campaign dedicated to the new 1 MW NBI, the beam duct heating was measured by a row of thermocouples located on the top-half of the beam duct. The fast ions collisions with the duct wall cause a local temperature increase with a characteristic pattern. In COMPASS, the location of the fast ions power deposition measured experimentally is in qualitative agreement with modelling of ion losses when following them after the re-ionization process. We trace back the details of the orbits corresponding to deposition at the hot-spot inside the beam duct. Quantitative comparison between the experiment and the simulation shows that a larger than expected amount of neutral gas was inside the duct and this study will guide the design of the future NBI duct in COMPASS Upgrade. [ABSTRACT FROM AUTHOR]

Published
2022
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11. Dependence on plasma shape and plasma fueling for small edge-localized mode regimes in TCV and ASDEX Upgrade

Author

Labit, B, Eich, T, Harrer, G, Wolfrum, E, Bernert, M, Dunne, M, Frassinetti, L, Hennequin, P, Maurizio, R, Merle, A, Meyer, H, Saarelma, S, Sheikh, U, Adamek, J, Agostini, M, Aguiam, D, Akers, R, Albanese, R, Albert, C, Alessi, E, Ambrosino, R, Andr be, Y, Angioni, C, Apruzzese, G, Aradi, M, Arnichand, H, Auriemma, F, Avdeeva, G, Ayllon-Guerola, J, Bagnato, F, Bandaru, V, Barnes, M, Barrera-Orte, L, Bettini, P, Bilato, R, Biletskyi, O, Bilkova, P, Bin, W, Blanchard, P, Blanken, T, Bobkov, V, Bock, A, Boeyaert, D, Bogar, K, Bogar, O, Bohm, P, Bolzonella, T, Bombarda, F, Boncagni, L, Bouquey, F, Bowman, C, Brezinsek, S, Brida, D, Brunetti, D, Bucalossi, J, Buchanan, J, Buermans, J, Bufferand, H, Buller, S, Buratti, P, Burckhart, A, Calabr, G, Calacci, L, Camenen, Y, Cannas, B, Cano Megias, P, Carnevale, D, Carpanese, F, Carr, M, Carralero, D, Carraro, L, Casolari, A, Cathey, A, Causa, F, Cavedon, M, Cecconello, M, Ceccuzzi, S, Cerovsky, J, Chapman, S, Chmielewski, P, Choi, D, Cianfarani, C, Ciraolo, G, Coda, S, Coelho, R, Colas, L, Colette, D, Cordaro, L, Cordella, F, Costea, S, Coster, D, Cruz Zabala, D, Cseh, G, Czarnecka, A, Cziegler, I, D'Arcangelo, O, Dal Molin, A, David, P, De Carolis, G, De Oliveira, H, Decker, J, Dejarnac, R, Delogu, R, Den Harder, N, Dimitrova, M, Dolizy, F, Dominguez-Palacios Duran, J, Douai, D, Drenik, A, Dreval, M, Dudson, B, Dunai, D, Duval, B, Dux, R, Elmore, S, Embreus, O, Erds, B, Fable, E, Faitsch, M, Fanni, A, Farnik, M, Faust, I, Faustin, J, Fedorczak, N, Felici, F, Feng, S, Feng, X, Ferreira, J, Ferr, G, Fevrier, O, Ficker, O, Figini, L, Figueiredo, A, Fil, A, Fontana, M, Francesco, M, Fuchs, C, Futatani, S, Gabellieri, L, Gadariya, D, Gahle, D, Galassi, D, Galazka, K, Galdon-Quiroga, J, Galeani, S, Gallart, D, Gallo, A, Galperti, C, Garavaglia, S, Garcia, J, Garcia-Lopez, J, Garcia-Mu oz, M, Garzotti, L, Gath, J, Geiger, B, Giacomelli, L, Giannone, L, Gibson, S, Gil, L, Giovannozzi, E, Giruzzi, G, Gobbin, M, Gonzalez-Martin, J, Goodman, T, Gorini, G, Gospodarczyk, M, Granucci, G, Grekov, D, Grenfell, G, Griener, M, Groth, M, Grover, O, Gruca, M, Gude, A, Guimarais, L, Gyergyek, T, Hacek, P, Hakola, A, Ham, C, Happel, T, Harrison, J, Havranek, A, Hawke, J, Henderson, S, Hesslow, L, Hitzler, F, Hnat, B, Hobirk, J, Hoelzl, M, Hogeweij, D, Hopf, C, Hoppe, M, Horacek, J, Hron, M, Huang, Z, Iantchenko, A, Iglesias, D, Igochine, V, Innocente, P, Ionita-Schrittwieser, C, Isliker, H, Ivanova-Stanik, I, Jacobsen, A, Jakubowski, M, Janky, F, Jardin, A, Jaulmes, F, Jensen, T, Jonsson, T, Kallenbach, A, Kappatou, A, Karpushov, A, Kasilov, S, Kazakov, Y, Kazantzidis, P, Keeling, D, Kelemen, M, Kendl, A, Kernbichler, W, Kirk, A, Kocsis, G, Komm, M, Kong, M, Korovin, V, Koubiti, M, Kovacic, J, Krawczyk, N, Krieger, K, Kripner, L, Krivska, A, Kudlacek, O, Kulyk, Y, Kurki-Suonio, T, Kwiatkowski, R, Laggner, F, Laguardia, L, Lahtinen, A, Lang, P, Likonen, J, Lipschultz, B, Liu, F, Lombroni, R, Lorenzini, R, Loschiavo, V, Lunt, T, Macusova, E, Madsen, J, Maggiora, R, Maljaars, B, Manas, P, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Marchenko, V, Marchetto, C, Mariani, A, Marini, C, Markovic, T, Marrelli, L, Martin, P, Martin Solis, J, Martitsch, A, Mastrostefano, S, Matos, F, Matthews, G, Mayoral, M, Mazon, D, Mazzotta, C, Mc Carthy, P, Mcclements, K, Mcdermott, R, Mcmillan, B, Meineri, C, Menkovski, V, Meshcheriakov, D, Messmer, M, Micheletti, D, Milanesio, D, Militello, F, Miron, I, Mlynar, J, Moiseenko, V, Molina Cabrera, P, Morales, J, Moret, J, Moro, A, Moulton, D, Nabais, F, Naulin, V, Naydenkova, D, Nem, R, Nespoli, F, Newton, S, Nielsen, A, Nielsen, S, Nikolaeva, V, Nocente, M, Nowak, S, Oberkofler, M, Ochoukov, R, Ollus, P, Olsen, J, Omotani, J, Ongena, J, Orain, F, Orsitto, F, Paccagnella, R, Palha, A, Panaccione, L, Panek, R, Panjan, M, Papp, G, Paradela Perez, I, Parra, F, Passeri, M, Pau, A, Pautasso, G, Pavlichenko, R, Perek, A, Pericoli Radolfini, V, Pesamosca, F, Peterka, M, Petrzilka, V, Piergotti, V, Pigatto, L, Piovesan, P, Piron, C, Piron, L, Plyusnin, V, Pokol, G, Poli, E, Poloskei, P, Popov, T, Popovic, Z, Por, G, Porte, L, Pucella, G, Puiatti, M, Putterich, T, Rabinski, M, Juul Rasmussen, J, Rasmussen, J, Ratta, G, Ratynskaia, S, Ravensbergen, T, Refy, D, Reich, M, Reimerdes, H, Reimold, F, Reiser, D, Reux, C, Reznik, S, Ricci, D, Rispoli, N, Rivero-Rodriguez, J, Rocchi, G, Rodriguez-Ramos, M, Romano, A, Rosato, J, Rubinacci, G, Rubino, G, Ryan, D, Salewski, M, Salmi, A, Samaddar, D, Sanchis-Sanchez, L, Santos, J, Sarkimaki, K, Sassano, M, Sauter, O, Scannell, R, Scheffer, M, Schneider, B, Schneider, P, Schrittwieser, R, Schubert, M, Seidl, J, Seliunin, E, Sharapov, S, Sheeba, R, Sias, G, Sieglin, B, Silva, C, Sipila, S, Smith, S, Snicker, A, Solano, E, Hansen, S, Soria-Hoyo, C, Sorokovoy, E, Sozzi, C, Sperduti, A, Spizzo, G, Spolaore, M, Stejner, M, Stipani, L, Stober, J, Strand, P, Sun, H, Suttrop, W, Sytnykov, D, Szepesi, T, Tal, B, Tala, T, Tardini, G, Tardocchi, M, Teplukhina, A, Terranova, D, Testa, D, Theiler, C, Thoren, E, Thornton, A, Tilia, B, Tolias, P, Tomes, M, Toscano-Jimenez, M, Tsironis, C, Tsui, C, Tudisco, O, Urban, J, Valisa, M, Vallar, M, Vallejos Olivares, P, Valovic, M, Van Vugt, D, Vanovac, B, Varje, J, Varju, J, Varoutis, S, Vartanian, S, Vasilovici, O, Vega, J, Verdoolaege, G, Verhaegh, K, Vermare, L, Vianello, N, Vicente, J, Viezzer, E, Villone, F, Voitsekhovitch, I, Voltolina, D, Vondracek, P, Vu, N, Walkden, N, Wauters, T, Weiland, M, Weinzettl, V, Wensing, M, Wiesen, S, Wiesenberger, M, Wilkie, G, Willensdorfer, M, Wischmeier, M, Wu, K, Xiang, L, Zagorski, R, Zaloga, D, Zanca, P, Zaplotnik, R, Zebrowski, J, Zhang, W, Zisis, A, Zoletnik, S, Zuin, M, Labit B., Eich T., Harrer G. F., Wolfrum E., Bernert M., Dunne M. G., Frassinetti L., Hennequin P., Maurizio R., Merle A., Meyer H., Saarelma S., Sheikh U., Adamek J., Agostini M., Aguiam D., Akers R., Albanese R., Albert C., Alessi E., Ambrosino R., Andr be Y., Angioni C., Apruzzese G., Aradi M., Arnichand H., Auriemma F., Avdeeva G., Ayllon-Guerola J. M., Bagnato F., Bandaru V. K., Barnes M., Barrera-Orte L., Bettini P., Bilato R., Biletskyi O., Bilkova P., Bin W., Blanchard P., Blanken T., Bobkov V., Bock A., Boeyaert D., Bogar K., Bogar O., Bohm P., Bolzonella T., Bombarda F., Boncagni L., Bouquey F., Bowman C., Brezinsek S., Brida D., Brunetti D., Bucalossi J., Buchanan J., Buermans J., Bufferand H., Buller S., Buratti P., Burckhart A., Calabr G., Calacci L., Camenen Y., Cannas B., Cano Megias P., Carnevale D., Carpanese F., Carr M., Carralero D., Carraro L., Casolari A., Cathey A., Causa F., Cavedon M., Cecconello M., Ceccuzzi S., Cerovsky J., Chapman S., Chmielewski P., Choi D., Cianfarani C., Ciraolo G., Coda S., Coelho R., Colas L., Colette D., Cordaro L., Cordella F., Costea S., Coster D., Cruz Zabala D. J., Cseh G., Czarnecka A., Cziegler I., D'Arcangelo O., Dal Molin A., David P., De Carolis G., De Oliveira H., Decker J., Dejarnac R., Delogu R., Den Harder N., Dimitrova M., Dolizy F., Dominguez-Palacios Duran J. J., Douai D., Drenik A., Dreval M., Dudson B., Dunai D., Duval B. P., Dux R., Elmore S., Embreus O., Erds B., Fable E., Faitsch M., Fanni A., Farnik M., Faust I., Faustin J., Fedorczak N., Felici F., Feng S., Feng X., Ferreira J., Ferr G., Fevrier O., Ficker O., Figini L., Figueiredo A., Fil A., Fontana M., Francesco M., Fuchs C., Futatani S., Gabellieri L., Gadariya D., Gahle D., Galassi D., Galazka K., Galdon-Quiroga J., Galeani S., Gallart D., Gallo A., Galperti C., Garavaglia S., Garcia J., Garcia-Lopez J., Garcia-Mu oz M., Garzotti L., Gath J., Geiger B., Giacomelli L., Giannone L., Gibson S., Gil L., Giovannozzi E., Giruzzi G., Gobbin M., Gonzalez-Martin J., Goodman T. P., Gorini G., Gospodarczyk M., GRANUCCI, GUSTAVO, Grekov D., Grenfell G., Griener M., Groth M., Grover O., Gruca M., Gude A., Guimarais L., Gyergyek T., Hacek P., Hakola A., Ham C., Happel T., Harrison J., Havranek A., Hawke J., Henderson S., Hesslow L., Hitzler F., Hnat B., Hobirk J., Hoelzl M., Hogeweij D., Hopf C., Hoppe M., Horacek J., Hron M., Huang Z., Iantchenko A., Iglesias D., Igochine V., Innocente P., Ionita-Schrittwieser C., Isliker H., Ivanova-Stanik I., Jacobsen A., Jakubowski M., Janky F., Jardin A., Jaulmes F., Jensen T., Jonsson T., Kallenbach A., Kappatou A., Karpushov A., Kasilov S., Kazakov Y., Kazantzidis P. V., Keeling D., Kelemen M., Kendl A., Kernbichler W., Kirk A., Kocsis G., Komm M., Kong M., Korovin V., Koubiti M., Kovacic J., Krawczyk N., Krieger K., Kripner L., Krivska A., Kudlacek O., Kulyk Y., Kurki-Suonio T., Kwiatkowski R., Laggner F., Laguardia L., Lahtinen A., Lang P., Likonen J., Lipschultz B., Liu F., Lombroni R., Lorenzini R., Loschiavo V. P., Lunt T., MacUsova E., Madsen J., Maggiora R., Maljaars B., Manas P., Mantica P., Mantsinen M. J., Manz P., Maraschek M., Marchenko V., Marchetto C., MARIANI, ALBERTO, Marini C., Markovic T., Marrelli L., Martin P., Martin Solis J. R., Martitsch A., Mastrostefano S., Matos F., Matthews G., Mayoral M. -L., Mazon D., Mazzotta C., Mc Carthy P., McClements K., McDermott R., McMillan B., Meineri C., Menkovski V., Meshcheriakov D., Messmer M., Micheletti D., Milanesio D., Militello F., Miron I. G., Mlynar J., Moiseenko V., Molina Cabrera P. A., Morales J., Moret J. -M., Moro A., Moulton D., Nabais F., Naulin V., Naydenkova D., Nem R. D., Nespoli F., Newton S., Nielsen A. H., Nielsen S. K., Nikolaeva V., Nocente M., Nowak S., Oberkofler M., Ochoukov R., Ollus P., Olsen J., Omotani J., Ongena J., Orain F., Orsitto F. P., Paccagnella R., Palha A., Panaccione L., Panek R., Panjan M., Papp G., Paradela Perez I., Parra F., Passeri M., Pau A., Pautasso G., Pavlichenko R., Perek A., Pericoli Radolfini V., Pesamosca F., Peterka M., Petrzilka V., Piergotti V., Pigatto L., Piovesan P., Piron C., Piron L., Plyusnin V., Pokol G., Poli E., Poloskei P., Popov T., Popovic Z., Por G., Porte L., Pucella G., Puiatti M. E., Putterich T., Rabinski M., Juul Rasmussen J., Rasmussen J., Ratta G. A., Ratynskaia S., Ravensbergen T., Refy D., Reich M., Reimerdes H., Reimold F., Reiser D., Reux C., Reznik S., Ricci D., Rispoli N., Rivero-Rodriguez J. F., Rocchi G., Rodriguez-Ramos M., Romano A., Rosato J., Rubinacci G., Rubino G., Ryan D. A., Salewski M., Salmi A., Samaddar D., Sanchis-Sanchez L., Santos J., Sarkimaki K., Sassano M., Sauter O., Scannell R., Scheffer M., Schneider B. S., Schneider P., Schrittwieser R., Schubert M., Seidl J., Seliunin E., Sharapov S., Sheeba R. R., Sias G., Sieglin B., Silva C., Sipila S., Smith S., Snicker A., Solano E. R., Hansen S. K., Soria-Hoyo C., Sorokovoy E., Sozzi C., Sperduti A., Spizzo G., Spolaore M., Stejner M., Stipani L., Stober J., Strand P., Sun H., Suttrop W., Sytnykov D., Szepesi T., Tal B., Tala T., Tardini G., Tardocchi M., Teplukhina A., Terranova D., Testa D., Theiler C., Thoren E., Thornton A., Tilia B., Tolias P., Tomes M., Toscano-Jimenez M., Tsironis C., Tsui C., Tudisco O., Urban J., Valisa M., Vallar M., Vallejos Olivares P., Valovic M., Van Vugt D., Vanovac B., Varje J., Varju J., Varoutis S., Vartanian S., Vasilovici O., Vega J., Verdoolaege G., Verhaegh K., Vermare L., Vianello N., Vicente J., Viezzer E., Villone F., Voitsekhovitch I., Voltolina D., Vondracek P., Vu N. M. T., Walkden N., Wauters T., Weiland M., Weinzettl V., Wensing M., Wiesen S., Wiesenberger M., Wilkie G., Willensdorfer M., Wischmeier M., Wu K., Xiang L., Zagorski R., Zaloga D., Zanca P., Zaplotnik R., Zebrowski J., Zhang W., Zisis A., Zoletnik S., Zuin M., Labit, B, Eich, T, Harrer, G, Wolfrum, E, Bernert, M, Dunne, M, Frassinetti, L, Hennequin, P, Maurizio, R, Merle, A, Meyer, H, Saarelma, S, Sheikh, U, Adamek, J, Agostini, M, Aguiam, D, Akers, R, Albanese, R, Albert, C, Alessi, E, Ambrosino, R, Andr be, Y, Angioni, C, Apruzzese, G, Aradi, M, Arnichand, H, Auriemma, F, Avdeeva, G, Ayllon-Guerola, J, Bagnato, F, Bandaru, V, Barnes, M, Barrera-Orte, L, Bettini, P, Bilato, R, Biletskyi, O, Bilkova, P, Bin, W, Blanchard, P, Blanken, T, Bobkov, V, Bock, A, Boeyaert, D, Bogar, K, Bogar, O, Bohm, P, Bolzonella, T, Bombarda, F, Boncagni, L, Bouquey, F, Bowman, C, Brezinsek, S, Brida, D, Brunetti, D, Bucalossi, J, Buchanan, J, Buermans, J, Bufferand, H, Buller, S, Buratti, P, Burckhart, A, Calabr, G, Calacci, L, Camenen, Y, Cannas, B, Cano Megias, P, Carnevale, D, Carpanese, F, Carr, M, Carralero, D, Carraro, L, Casolari, A, Cathey, A, Causa, F, Cavedon, M, Cecconello, M, Ceccuzzi, S, Cerovsky, J, Chapman, S, Chmielewski, P, Choi, D, Cianfarani, C, Ciraolo, G, Coda, S, Coelho, R, Colas, L, Colette, D, Cordaro, L, Cordella, F, Costea, S, Coster, D, Cruz Zabala, D, Cseh, G, Czarnecka, A, Cziegler, I, D'Arcangelo, O, Dal Molin, A, David, P, De Carolis, G, De Oliveira, H, Decker, J, Dejarnac, R, Delogu, R, Den Harder, N, Dimitrova, M, Dolizy, F, Dominguez-Palacios Duran, J, Douai, D, Drenik, A, Dreval, M, Dudson, B, Dunai, D, Duval, B, Dux, R, Elmore, S, Embreus, O, Erds, B, Fable, E, Faitsch, M, Fanni, A, Farnik, M, Faust, I, Faustin, J, Fedorczak, N, Felici, F, Feng, S, Feng, X, Ferreira, J, Ferr, G, Fevrier, O, Ficker, O, Figini, L, Figueiredo, A, Fil, A, Fontana, M, Francesco, M, Fuchs, C, Futatani, S, Gabellieri, L, Gadariya, D, Gahle, D, Galassi, D, Galazka, K, Galdon-Quiroga, J, Galeani, S, Gallart, D, Gallo, A, Galperti, C, Garavaglia, S, Garcia, J, Garcia-Lopez, J, Garcia-Mu oz, M, Garzotti, L, Gath, J, Geiger, B, Giacomelli, L, Giannone, L, Gibson, S, Gil, L, Giovannozzi, E, Giruzzi, G, Gobbin, M, Gonzalez-Martin, J, Goodman, T, Gorini, G, Gospodarczyk, M, Granucci, G, Grekov, D, Grenfell, G, Griener, M, Groth, M, Grover, O, Gruca, M, Gude, A, Guimarais, L, Gyergyek, T, Hacek, P, Hakola, A, Ham, C, Happel, T, Harrison, J, Havranek, A, Hawke, J, Henderson, S, Hesslow, L, Hitzler, F, Hnat, B, Hobirk, J, Hoelzl, M, Hogeweij, D, Hopf, C, Hoppe, M, Horacek, J, Hron, M, Huang, Z, Iantchenko, A, Iglesias, D, Igochine, V, Innocente, P, Ionita-Schrittwieser, C, Isliker, H, Ivanova-Stanik, I, Jacobsen, A, Jakubowski, M, Janky, F, Jardin, A, Jaulmes, F, Jensen, T, Jonsson, T, Kallenbach, A, Kappatou, A, Karpushov, A, Kasilov, S, Kazakov, Y, Kazantzidis, P, Keeling, D, Kelemen, M, Kendl, A, Kernbichler, W, Kirk, A, Kocsis, G, Komm, M, Kong, M, Korovin, V, Koubiti, M, Kovacic, J, Krawczyk, N, Krieger, K, Kripner, L, Krivska, A, Kudlacek, O, Kulyk, Y, Kurki-Suonio, T, Kwiatkowski, R, Laggner, F, Laguardia, L, Lahtinen, A, Lang, P, Likonen, J, Lipschultz, B, Liu, F, Lombroni, R, Lorenzini, R, Loschiavo, V, Lunt, T, Macusova, E, Madsen, J, Maggiora, R, Maljaars, B, Manas, P, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Marchenko, V, Marchetto, C, Mariani, A, Marini, C, Markovic, T, Marrelli, L, Martin, P, Martin Solis, J, Martitsch, A, Mastrostefano, S, Matos, F, Matthews, G, Mayoral, M, Mazon, D, Mazzotta, C, Mc Carthy, P, Mcclements, K, Mcdermott, R, Mcmillan, B, Meineri, C, Menkovski, V, Meshcheriakov, D, Messmer, M, Micheletti, D, Milanesio, D, Militello, F, Miron, I, Mlynar, J, Moiseenko, V, Molina Cabrera, P, Morales, J, Moret, J, Moro, A, Moulton, D, Nabais, F, Naulin, V, Naydenkova, D, Nem, R, Nespoli, F, Newton, S, Nielsen, A, Nielsen, S, Nikolaeva, V, Nocente, M, Nowak, S, Oberkofler, M, Ochoukov, R, Ollus, P, Olsen, J, Omotani, J, Ongena, J, Orain, F, Orsitto, F, Paccagnella, R, Palha, A, Panaccione, L, Panek, R, Panjan, M, Papp, G, Paradela Perez, I, Parra, F, Passeri, M, Pau, A, Pautasso, G, Pavlichenko, R, Perek, A, Pericoli Radolfini, V, Pesamosca, F, Peterka, M, Petrzilka, V, Piergotti, V, Pigatto, L, Piovesan, P, Piron, C, Piron, L, Plyusnin, V, Pokol, G, Poli, E, Poloskei, P, Popov, T, Popovic, Z, Por, G, Porte, L, Pucella, G, Puiatti, M, Putterich, T, Rabinski, M, Juul Rasmussen, J, Rasmussen, J, Ratta, G, Ratynskaia, S, Ravensbergen, T, Refy, D, Reich, M, Reimerdes, H, Reimold, F, Reiser, D, Reux, C, Reznik, S, Ricci, D, Rispoli, N, Rivero-Rodriguez, J, Rocchi, G, Rodriguez-Ramos, M, Romano, A, Rosato, J, Rubinacci, G, Rubino, G, Ryan, D, Salewski, M, Salmi, A, Samaddar, D, Sanchis-Sanchez, L, Santos, J, Sarkimaki, K, Sassano, M, Sauter, O, Scannell, R, Scheffer, M, Schneider, B, Schneider, P, Schrittwieser, R, Schubert, M, Seidl, J, Seliunin, E, Sharapov, S, Sheeba, R, Sias, G, Sieglin, B, Silva, C, Sipila, S, Smith, S, Snicker, A, Solano, E, Hansen, S, Soria-Hoyo, C, Sorokovoy, E, Sozzi, C, Sperduti, A, Spizzo, G, Spolaore, M, Stejner, M, Stipani, L, Stober, J, Strand, P, Sun, H, Suttrop, W, Sytnykov, D, Szepesi, T, Tal, B, Tala, T, Tardini, G, Tardocchi, M, Teplukhina, A, Terranova, D, Testa, D, Theiler, C, Thoren, E, Thornton, A, Tilia, B, Tolias, P, Tomes, M, Toscano-Jimenez, M, Tsironis, C, Tsui, C, Tudisco, O, Urban, J, Valisa, M, Vallar, M, Vallejos Olivares, P, Valovic, M, Van Vugt, D, Vanovac, B, Varje, J, Varju, J, Varoutis, S, Vartanian, S, Vasilovici, O, Vega, J, Verdoolaege, G, Verhaegh, K, Vermare, L, Vianello, N, Vicente, J, Viezzer, E, Villone, F, Voitsekhovitch, I, Voltolina, D, Vondracek, P, Vu, N, Walkden, N, Wauters, T, Weiland, M, Weinzettl, V, Wensing, M, Wiesen, S, Wiesenberger, M, Wilkie, G, Willensdorfer, M, Wischmeier, M, Wu, K, Xiang, L, Zagorski, R, Zaloga, D, Zanca, P, Zaplotnik, R, Zebrowski, J, Zhang, W, Zisis, A, Zoletnik, S, Zuin, M, Labit B., Eich T., Harrer G. F., Wolfrum E., Bernert M., Dunne M. G., Frassinetti L., Hennequin P., Maurizio R., Merle A., Meyer H., Saarelma S., Sheikh U., Adamek J., Agostini M., Aguiam D., Akers R., Albanese R., Albert C., Alessi E., Ambrosino R., Andr be Y., Angioni C., Apruzzese G., Aradi M., Arnichand H., Auriemma F., Avdeeva G., Ayllon-Guerola J. M., Bagnato F., Bandaru V. K., Barnes M., Barrera-Orte L., Bettini P., Bilato R., Biletskyi O., Bilkova P., Bin W., Blanchard P., Blanken T., Bobkov V., Bock A., Boeyaert D., Bogar K., Bogar O., Bohm P., Bolzonella T., Bombarda F., Boncagni L., Bouquey F., Bowman C., Brezinsek S., Brida D., Brunetti D., Bucalossi J., Buchanan J., Buermans J., Bufferand H., Buller S., Buratti P., Burckhart A., Calabr G., Calacci L., Camenen Y., Cannas B., Cano Megias P., Carnevale D., Carpanese F., Carr M., Carralero D., Carraro L., Casolari A., Cathey A., Causa F., Cavedon M., Cecconello M., Ceccuzzi S., Cerovsky J., Chapman S., Chmielewski P., Choi D., Cianfarani C., Ciraolo G., Coda S., Coelho R., Colas L., Colette D., Cordaro L., Cordella F., Costea S., Coster D., Cruz Zabala D. J., Cseh G., Czarnecka A., Cziegler I., D'Arcangelo O., Dal Molin A., David P., De Carolis G., De Oliveira H., Decker J., Dejarnac R., Delogu R., Den Harder N., Dimitrova M., Dolizy F., Dominguez-Palacios Duran J. J., Douai D., Drenik A., Dreval M., Dudson B., Dunai D., Duval B. P., Dux R., Elmore S., Embreus O., Erds B., Fable E., Faitsch M., Fanni A., Farnik M., Faust I., Faustin J., Fedorczak N., Felici F., Feng S., Feng X., Ferreira J., Ferr G., Fevrier O., Ficker O., Figini L., Figueiredo A., Fil A., Fontana M., Francesco M., Fuchs C., Futatani S., Gabellieri L., Gadariya D., Gahle D., Galassi D., Galazka K., Galdon-Quiroga J., Galeani S., Gallart D., Gallo A., Galperti C., Garavaglia S., Garcia J., Garcia-Lopez J., Garcia-Mu oz M., Garzotti L., Gath J., Geiger B., Giacomelli L., Giannone L., Gibson S., Gil L., Giovannozzi E., Giruzzi G., Gobbin M., Gonzalez-Martin J., Goodman T. P., Gorini G., Gospodarczyk M., GRANUCCI, GUSTAVO, Grekov D., Grenfell G., Griener M., Groth M., Grover O., Gruca M., Gude A., Guimarais L., Gyergyek T., Hacek P., Hakola A., Ham C., Happel T., Harrison J., Havranek A., Hawke J., Henderson S., Hesslow L., Hitzler F., Hnat B., Hobirk J., Hoelzl M., Hogeweij D., Hopf C., Hoppe M., Horacek J., Hron M., Huang Z., Iantchenko A., Iglesias D., Igochine V., Innocente P., Ionita-Schrittwieser C., Isliker H., Ivanova-Stanik I., Jacobsen A., Jakubowski M., Janky F., Jardin A., Jaulmes F., Jensen T., Jonsson T., Kallenbach A., Kappatou A., Karpushov A., Kasilov S., Kazakov Y., Kazantzidis P. V., Keeling D., Kelemen M., Kendl A., Kernbichler W., Kirk A., Kocsis G., Komm M., Kong M., Korovin V., Koubiti M., Kovacic J., Krawczyk N., Krieger K., Kripner L., Krivska A., Kudlacek O., Kulyk Y., Kurki-Suonio T., Kwiatkowski R., Laggner F., Laguardia L., Lahtinen A., Lang P., Likonen J., Lipschultz B., Liu F., Lombroni R., Lorenzini R., Loschiavo V. P., Lunt T., MacUsova E., Madsen J., Maggiora R., Maljaars B., Manas P., Mantica P., Mantsinen M. J., Manz P., Maraschek M., Marchenko V., Marchetto C., MARIANI, ALBERTO, Marini C., Markovic T., Marrelli L., Martin P., Martin Solis J. R., Martitsch A., Mastrostefano S., Matos F., Matthews G., Mayoral M. -L., Mazon D., Mazzotta C., Mc Carthy P., McClements K., McDermott R., McMillan B., Meineri C., Menkovski V., Meshcheriakov D., Messmer M., Micheletti D., Milanesio D., Militello F., Miron I. G., Mlynar J., Moiseenko V., Molina Cabrera P. A., Morales J., Moret J. -M., Moro A., Moulton D., Nabais F., Naulin V., Naydenkova D., Nem R. D., Nespoli F., Newton S., Nielsen A. H., Nielsen S. K., Nikolaeva V., Nocente M., Nowak S., Oberkofler M., Ochoukov R., Ollus P., Olsen J., Omotani J., Ongena J., Orain F., Orsitto F. P., Paccagnella R., Palha A., Panaccione L., Panek R., Panjan M., Papp G., Paradela Perez I., Parra F., Passeri M., Pau A., Pautasso G., Pavlichenko R., Perek A., Pericoli Radolfini V., Pesamosca F., Peterka M., Petrzilka V., Piergotti V., Pigatto L., Piovesan P., Piron C., Piron L., Plyusnin V., Pokol G., Poli E., Poloskei P., Popov T., Popovic Z., Por G., Porte L., Pucella G., Puiatti M. E., Putterich T., Rabinski M., Juul Rasmussen J., Rasmussen J., Ratta G. A., Ratynskaia S., Ravensbergen T., Refy D., Reich M., Reimerdes H., Reimold F., Reiser D., Reux C., Reznik S., Ricci D., Rispoli N., Rivero-Rodriguez J. F., Rocchi G., Rodriguez-Ramos M., Romano A., Rosato J., Rubinacci G., Rubino G., Ryan D. A., Salewski M., Salmi A., Samaddar D., Sanchis-Sanchez L., Santos J., Sarkimaki K., Sassano M., Sauter O., Scannell R., Scheffer M., Schneider B. S., Schneider P., Schrittwieser R., Schubert M., Seidl J., Seliunin E., Sharapov S., Sheeba R. R., Sias G., Sieglin B., Silva C., Sipila S., Smith S., Snicker A., Solano E. R., Hansen S. K., Soria-Hoyo C., Sorokovoy E., Sozzi C., Sperduti A., Spizzo G., Spolaore M., Stejner M., Stipani L., Stober J., Strand P., Sun H., Suttrop W., Sytnykov D., Szepesi T., Tal B., Tala T., Tardini G., Tardocchi M., Teplukhina A., Terranova D., Testa D., Theiler C., Thoren E., Thornton A., Tilia B., Tolias P., Tomes M., Toscano-Jimenez M., Tsironis C., Tsui C., Tudisco O., Urban J., Valisa M., Vallar M., Vallejos Olivares P., Valovic M., Van Vugt D., Vanovac B., Varje J., Varju J., Varoutis S., Vartanian S., Vasilovici O., Vega J., Verdoolaege G., Verhaegh K., Vermare L., Vianello N., Vicente J., Viezzer E., Villone F., Voitsekhovitch I., Voltolina D., Vondracek P., Vu N. M. T., Walkden N., Wauters T., Weiland M., Weinzettl V., Wensing M., Wiesen S., Wiesenberger M., Wilkie G., Willensdorfer M., Wischmeier M., Wu K., Xiang L., Zagorski R., Zaloga D., Zanca P., Zaplotnik R., Zebrowski J., Zhang W., Zisis A., Zoletnik S., and Zuin M.

Abstract

Within the EUROfusion MST1 work package, a series of experiments has been conducted on AUG and TCV devices to disentangle the role of plasma fueling and plasma shape for the onset of small ELM regimes. On both devices, small ELM regimes with high confinement are achieved if and only if two conditions are fulfilled at the same time. Firstly, the plasma density at the separatrix must be large enough (ne,sep/nG ∼ 0.3), leading to a pressure profile flattening at the separatrix, which stabilizes type-I ELMs. Secondly, the magnetic configuration has to be close to a double null (DN), leading to a reduction of the magnetic shear in the extreme vicinity of the separatrix. As a consequence, its stabilizing effect on ballooning modes is weakened.

Published
2019

13. Determination of the background neutral density from passive Balmer alpha CX emission at the ASDEX Upgrade tokamak

Author

Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Universidad de Sevilla. Departamento de Ingeniería Energética, EUROfusion Consortium, Van Vuuren, A. J., Bogar, K., Cruz Zabala, Diego José, Cavedon, M., Cano Megías, Pilar, Kappatou, A., Dux, R., Schneider, P. A., Viezzer, Eleonora, Nishizawa, T., García Muñoz, Manuel, Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear, Universidad de Sevilla. Departamento de Ingeniería Energética, EUROfusion Consortium, Van Vuuren, A. J., Bogar, K., Cruz Zabala, Diego José, Cavedon, M., Cano Megías, Pilar, Kappatou, A., Dux, R., Schneider, P. A., Viezzer, Eleonora, Nishizawa, T., and García Muñoz, Manuel

Published
2021

18. Dependence on plasma shape and plasma fueling for small edge-localized mode regimes in TCV and ASDEX Upgrade

Author

Labit, B., Eich, T., Harrer, G.F., Wolfrum, E., Bernert, M., Dunne, M.G., Frassinetti, L., Hennequin, P., Maurizio, R., Merle, A., Meyer, H., Saarelma, S., Sheikh, U., Adamek, J., Agostini, M., Aguiam, D., Akers, R., Albanese, R., Albert, C., Alessi, E., Ambrosino, R., Andrèbe, Y., Angioni, C., Apruzzese, G., Aradi, M., Arnichand, H., Auriemma, F., Avdeeva, G., Ayllon-Guerola, J.M., Bagnato, F., Bandaru, V.K., Barnes, M., Barrera-Orte, L., Bettini, P., Bilato, R., Biletskyi, O., Bilkova, P., Bin, W., Blanchard, P., Blanken, T., Bobkov, V., Bock, A., Boeyaert, D., Bogar, K., Bogar, O., Bohm, P., Bolzonella, T., Bombarda, F., Boncagni, L., Bouquey, F., Moiseyenko, Volodymyr, Labit, B., Eich, T., Harrer, G.F., Wolfrum, E., Bernert, M., Dunne, M.G., Frassinetti, L., Hennequin, P., Maurizio, R., Merle, A., Meyer, H., Saarelma, S., Sheikh, U., Adamek, J., Agostini, M., Aguiam, D., Akers, R., Albanese, R., Albert, C., Alessi, E., Ambrosino, R., Andrèbe, Y., Angioni, C., Apruzzese, G., Aradi, M., Arnichand, H., Auriemma, F., Avdeeva, G., Ayllon-Guerola, J.M., Bagnato, F., Bandaru, V.K., Barnes, M., Barrera-Orte, L., Bettini, P., Bilato, R., Biletskyi, O., Bilkova, P., Bin, W., Blanchard, P., Blanken, T., Bobkov, V., Bock, A., Boeyaert, D., Bogar, K., Bogar, O., Bohm, P., Bolzonella, T., Bombarda, F., Boncagni, L., Bouquey, F., and Moiseyenko, Volodymyr

Published
2019
Full Text
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21. Dependence on plasma shape and plasma fueling for small edge-localized mode regimes in TCV and ASDEX Upgrade

Author

Labit, B., primary, Eich, T., additional, Harrer, G.F., additional, Wolfrum, E., additional, Bernert, M., additional, Dunne, M.G., additional, Frassinetti, L., additional, Hennequin, P., additional, Maurizio, R., additional, Merle, A., additional, Meyer, H., additional, Saarelma, S., additional, Sheikh, U., additional, Adamek, J., additional, Agostini, M., additional, Aguiam, D., additional, Akers, R., additional, Albanese, R., additional, Albert, C., additional, Alessi, E., additional, Ambrosino, R., additional, Andrèbe, Y., additional, Angioni, C., additional, Apruzzese, G., additional, Aradi, M., additional, Arnichand, H., additional, Auriemma, F., additional, Avdeeva, G., additional, Ayllon-Guerola, J.M., additional, Bagnato, F., additional, Bandaru, V.K., additional, Barnes, M., additional, Barrera-Orte, L., additional, Bettini, P., additional, Bilato, R., additional, Biletskyi, O., additional, Bilkova, P., additional, Bin, W., additional, Blanchard, P., additional, Blanken, T., additional, Bobkov, V., additional, Bock, A., additional, Boeyaert, D., additional, Bogar, K., additional, Bogar, O., additional, Bohm, P., additional, Bolzonella, T., additional, Bombarda, F., additional, Boncagni, L., additional, Bouquey, F., additional, Bowman, C., additional, Brezinsek, S., additional, Brida, D., additional, Brunetti, D., additional, Bucalossi, J., additional, Buchanan, J., additional, Buermans, J., additional, Bufferand, H., additional, Buller, S., additional, Buratti, P., additional, Burckhart, A., additional, Calabrò, G., additional, Calacci, L., additional, Camenen, Y., additional, Cannas, B., additional, Cano Megías, P., additional, Carnevale, D., additional, Carpanese, F., additional, Carr, M., additional, Carralero, D., additional, Carraro, L., additional, Casolari, A., additional, Cathey, A., additional, Causa, F., additional, Cavedon, M., additional, Cecconello, M., additional, Ceccuzzi, S., additional, Cerovsky, J., additional, Chapman, S., additional, Chmielewski, P., additional, Choi, D., additional, Cianfarani, C., additional, Ciraolo, G., additional, Coda, S., additional, Coelho, R., additional, Colas, L., additional, Colette, D., additional, Cordaro, L., additional, Cordella, F., additional, Costea, S., additional, Coster, D., additional, Cruz Zabala, D.J., additional, Cseh, G., additional, Czarnecka, A., additional, Cziegler, I., additional, D’Arcangelo, O., additional, Dal Molin, A., additional, David, P., additional, De Carolis, G., additional, De Oliveira, H., additional, Decker, J., additional, Dejarnac, R., additional, Delogu, R., additional, den Harder, N., additional, Dimitrova, M., additional, Dolizy, F., additional, Domínguez-Palacios Durán, J.J., additional, Douai, D., additional, Drenik, A., additional, Dreval, M., additional, Dudson, B., additional, Dunai, D., additional, Duval, B.P., additional, Dux, R., additional, Elmore, S., additional, Embréus, O., additional, Erdõs, B., additional, Fable, E., additional, Faitsch, M., additional, Fanni, A., additional, Farnik, M., additional, Faust, I., additional, Faustin, J., additional, Fedorczak, N., additional, Felici, F., additional, Feng, S., additional, Feng, X., additional, Ferreira, J., additional, Ferrò, G., additional, Février, O., additional, Ficker, O., additional, Figini, L., additional, Figueiredo, A., additional, Fil, A., additional, Fontana, M., additional, Francesco, M., additional, Fuchs, C., additional, Futatani, S., additional, Gabellieri, L., additional, Gadariya, D., additional, Gahle, D., additional, Galassi, D., additional, Gałązka, K., additional, Galdon-Quiroga, J., additional, Galeani, S., additional, Gallart, D., additional, Gallo, A., additional, Galperti, C., additional, Garavaglia, S., additional, Garcia, J., additional, Garcia-Lopez, J., additional, Garcia-Muñoz, M., additional, Garzotti, L., additional, Gath, J., additional, Geiger, B., additional, Giacomelli, L., additional, Giannone, L., additional, Gibson, S., additional, Gil, L., additional, Giovannozzi, E., additional, Giruzzi, G., additional, Gobbin, M., additional, Gonzalez-Martin, J., additional, Goodman, T.P., additional, Gorini, G., additional, Gospodarczyk, M., additional, Granucci, G., additional, Grekov, D., additional, Grenfell, G., additional, Griener, M., additional, Groth, M., additional, Grover, O., additional, Gruca, M., additional, Gude, A., additional, Guimarais, L., additional, Gyergyek, T., additional, Hacek, P., additional, Hakola, A., additional, Ham, C., additional, Happel, T., additional, Harrison, J., additional, Havranek, A., additional, Hawke, J., additional, Henderson, S., additional, Hesslow, L., additional, Hitzler, F., additional, Hnat, B., additional, Hobirk, J., additional, Hoelzl, M., additional, Hogeweij, D., additional, Hopf, C., additional, Hoppe, M., additional, Horacek, J., additional, Hron, M., additional, Huang, Z., additional, Iantchenko, A., additional, Iglesias, D., additional, Igochine, V., additional, Innocente, P., additional, Ionita-Schrittwieser, C., additional, Isliker, H., additional, Ivanova-Stanik, I., additional, Jacobsen, A., additional, Jakubowski, M., additional, Janky, F., additional, Jardin, A., additional, Jaulmes, F., additional, Jensen, T., additional, Jonsson, T., additional, Kallenbach, A., additional, Kappatou, A., additional, Karpushov, A., additional, Kasilov, S., additional, Kazakov, Y., additional, Kazantzidis, P.V., additional, Keeling, D., additional, Kelemen, M., additional, Kendl, A., additional, Kernbichler, W., additional, Kirk, A., additional, Kocsis, G., additional, Komm, M., additional, Kong, M., additional, Korovin, V., additional, Koubiti, M., additional, Kovacic, J., additional, Krawczyk, N., additional, Krieger, K., additional, Kripner, L., additional, Křivská, A., additional, Kudlacek, O., additional, Kulyk, Y., additional, Kurki-Suonio, T., additional, Kwiatkowski, R., additional, Laggner, F., additional, Laguardia, L., additional, Lahtinen, A., additional, Lang, P., additional, Likonen, J., additional, Lipschultz, B., additional, Liu, F., additional, Lombroni, R., additional, Lorenzini, R., additional, Loschiavo, V.P., additional, Lunt, T., additional, Macusova, E., additional, Madsen, J., additional, Maggiora, R., additional, Maljaars, B., additional, Manas, P., additional, Mantica, P., additional, Mantsinen, M.J., additional, Manz, P., additional, Maraschek, M., additional, Marchenko, V., additional, Marchetto, C., additional, Mariani, A., additional, Marini, C., additional, Markovic, T., additional, Marrelli, L., additional, Martin, P., additional, Martín Solís, J.R., additional, Martitsch, A., additional, Mastrostefano, S., additional, Matos, F., additional, Matthews, G., additional, Mayoral, M.-L., additional, Mazon, D., additional, Mazzotta, C., additional, Mc Carthy, P., additional, McClements, K., additional, McDermott, R., additional, Mcmillan, B., additional, Meineri, C., additional, Menkovski, V., additional, Meshcheriakov, D., additional, Messmer, M., additional, Micheletti, D., additional, Milanesio, D., additional, Militello, F., additional, Miron, I.G., additional, Mlynar, J., additional, Moiseenko, V., additional, Molina Cabrera, P.A., additional, Morales, J., additional, Moret, J.-M., additional, Moro, A., additional, Moulton, D., additional, Nabais, F., additional, Naulin, V., additional, Naydenkova, D., additional, Nem, R.D., additional, Nespoli, F., additional, Newton, S., additional, Nielsen, A.H., additional, Nielsen, S.K., additional, Nikolaeva, V., additional, Nocente, M., additional, Nowak, S., additional, Oberkofler, M., additional, Ochoukov, R., additional, Ollus, P., additional, Olsen, J., additional, Omotani, J., additional, Ongena, J., additional, Orain, F., additional, Orsitto, F.P., additional, Paccagnella, R., additional, Palha, A., additional, Panaccione, L., additional, Panek, R., additional, Panjan, M., additional, Papp, G., additional, Paradela Perez, I., additional, Parra, F., additional, Passeri, M., additional, Pau, A., additional, Pautasso, G., additional, Pavlichenko, R., additional, Perek, A., additional, Pericoli Radolfini, V., additional, Pesamosca, F., additional, Peterka, M., additional, Petrzilka, V., additional, Piergotti, V., additional, Pigatto, L., additional, Piovesan, P., additional, Piron, C., additional, Piron, L., additional, Plyusnin, V., additional, Pokol, G., additional, Poli, E., additional, Pölöskei, P., additional, Popov, T., additional, Popovic, Z., additional, Pór, G., additional, Porte, L., additional, Pucella, G., additional, Puiatti, M.E., additional, Pütterich, T., additional, Rabinski, M., additional, Juul Rasmussen, J., additional, Rasmussen, J., additional, Rattá, G.A., additional, Ratynskaia, S., additional, Ravensbergen, T., additional, Réfy, D., additional, Reich, M., additional, Reimerdes, H., additional, Reimold, F., additional, Reiser, D., additional, Reux, C., additional, Reznik, S., additional, Ricci, D., additional, Rispoli, N., additional, Rivero-Rodriguez, J.F., additional, Rocchi, G., additional, Rodriguez-Ramos, M., additional, Romano, A., additional, Rosato, J., additional, Rubinacci, G., additional, Rubino, G., additional, Ryan, D.A., additional, Salewski, M., additional, Salmi, A., additional, Samaddar, D., additional, Sanchis-Sanchez, L., additional, Santos, J., additional, Särkimäki, K., additional, Sassano, M., additional, Sauter, O., additional, Scannell, R., additional, Scheffer, M., additional, Schneider, B.S., additional, Schneider, P., additional, Schrittwieser, R., additional, Schubert, M., additional, Seidl, J., additional, Seliunin, E., additional, Sharapov, S., additional, Sheeba, R.R., additional, Sias, G., additional, Sieglin, B., additional, Silva, C., additional, Sipilä, S., additional, Smith, S., additional, Snicker, A., additional, Solano, E.R., additional, Hansen, S.K., additional, Soria-Hoyo, C., additional, Sorokovoy, E., additional, Sozzi, C., additional, Sperduti, A., additional, Spizzo, G., additional, Spolaore, M., additional, Stejner, M., additional, Stipani, L., additional, Stober, J., additional, Strand, P., additional, Sun, H., additional, Suttrop, W., additional, Sytnykov, D., additional, Szepesi, T., additional, Tál, B., additional, Tala, T., additional, Tardini, G., additional, Tardocchi, M., additional, Teplukhina, A., additional, Terranova, D., additional, Testa, D., additional, Theiler, C., additional, Thorén, E., additional, Thornton, A., additional, Tilia, B., additional, Tolias, P., additional, Tomes, M., additional, Toscano-Jimenez, M., additional, Tsironis, C., additional, Tsui, C., additional, Tudisco, O., additional, Urban, J., additional, Valisa, M., additional, Vallar, M., additional, Vallejos Olivares, P., additional, Valovic, M., additional, Van Vugt, D., additional, Vanovac, B., additional, Varje, J., additional, Varju, J., additional, Varoutis, S., additional, Vartanian, S., additional, Vasilovici, O., additional, Vega, J., additional, Verdoolaege, G., additional, Verhaegh, K., additional, Vermare, L., additional, Vianello, N., additional, Vicente, J., additional, Viezzer, E., additional, Villone, F., additional, Voitsekhovitch, I., additional, Voltolina, D., additional, Vondracek, P., additional, Vu, N.M.T., additional, Walkden, N., additional, Wauters, T., additional, Weiland, M., additional, Weinzettl, V., additional, Wensing, M., additional, Wiesen, S., additional, Wiesenberger, M., additional, Wilkie, G., additional, Willensdorfer, M., additional, Wischmeier, M., additional, Wu, K., additional, Xiang, L., additional, Zagorski, R., additional, Zaloga, D., additional, Zanca, P., additional, Zaplotnik, R., additional, Zebrowski, J., additional, Zhang, W., additional, Zisis, A., additional, Zoletnik, S., additional, and Zuin, M., additional

Published
2019
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22. Experimental study of ELM induced fast-ion transport using passive FIDA spectroscopy at the ASDEX Upgrade tokamak.

Author

van Vuuren, A. Jansen, Geiger, B., Schneider, P.A., Bogar, K., Poloskei, P.Zs., Cathey, A., Hoelzl, M., Jacobsen, A.S., Cavedon, M., Dux, R., and Team, the ASDEX Upgrade

Subjects
BIOLOGICAL transport, FAST ions, PLASMA density, SPECTROMETRY, FLUX (Energy)
Abstract

Measurements using a recently installed edge fast-ion D-alpha (FIDA) diagnostic at the ASDEX Upgrade tokamak show a clear effect of edge localised modes (ELMs) on the passive FIDA signals. While a reduction in the passive FIDA emission is observed in the scrape-off layer (SOL) region, measurements close to the last closed flux surface show an increase in signals shortly after ELMs, followed by a decrease. The decrease provides a clear sign of fast-ion losses in the SOL, while the increase can be explained by an enhanced neutral density during ELMs inside the plasma. In addition, small ELMs are observed, which barely change the neutral density and plasma position but still cause significant changes in the passive FIDA signals. A comparison of the measurements with forward modelling shows that 60% to 80% of the fast ions are lost by ELMs outside the last closed flux surface. In addition, a 20% decrease of the fast-ion density in a range up to 4 cm within the last closed flux surface can be inferred. This range agrees well with the latest modelling results of ELMs using the non-linear MHD code JOREK and shows that less than 0.3% of all fast ions are lost by ELMs. [ABSTRACT FROM AUTHOR]

Published
2021
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23. Design and Synthesis of BACE1 Inhibitors with In Vivo Brain Reduction of beta-Amyloid Peptides (COMPOUND (R)-41)

Author

Swahn, B.M., primary, Kolmodin, K., additional, Karlstrom, S., additional, von Berg, S., additional, Soderman, P., additional, Holenz, J., additional, Berg, S., additional, Lindstrom, J., additional, Sundstrom, M., additional, Turek, D., additional, Kihlstrom, J., additional, Slivo, C., additional, Andersson, L., additional, Pyring, D., additional, Ohberg, L., additional, Kers, A., additional, Bogar, K., additional, Bergh, M., additional, Olsson, L.L., additional, Janson, J., additional, Eketjall, S., additional, Georgievska, B., additional, Jeppsson, F., additional, and Falting, J., additional

Published
2012
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24. Design and Synthesis of BACE1 Inhibitors with In Vivo Brain Reduction of beta-Amyloid Peptides (COMPOUND 10)

Author

Swahn, B.M., primary, Kolmodin, K., additional, Karlstrom, S., additional, von Berg, S., additional, Soderman, P., additional, Holenz, J., additional, Berg, S., additional, Lindstrom, J., additional, Sundstrom, M., additional, Turek, D., additional, Kihlstrom, J., additional, Slivo, C., additional, Andersson, L., additional, Pyring, D., additional, Ohberg, L., additional, Kers, A., additional, Bogar, K., additional, Bergh, M., additional, Olsson, L.L., additional, Janson, J., additional, Eketjall, S., additional, Georgievska, B., additional, Jeppsson, F., additional, and Falting, J., additional

Published
2012
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26. Addressing the ''Replication Crisis'' in Sports Neuropsychology: Validation of the Two-Factor Theory of ImPACT.

Author

Schatz, P, Bogar, K, and Elbin, R J

Subjects
*PSYCHOPHYSIOLOGY, *VISUAL memory, *VERBAL memory, *NEUROPSYCHOLOGY, *REACTION time, *EXPLORATORY factor analysis
Abstract

Purpose The "replication crisis" in psychology and across the broader field of social sciences raises criticism due to a lack of data to show that esoteric research findings can be replicated. The present study replicated and validated the two-factor "memory" and "speed" structure of ImPACT (Schatz & Maerlender, 2013). Methods High school aged athletes (N=18,918, Mean age=15.4, SD=1.2) who completed pre-season baseline ImPACT testing were randomly assigned to one of 5 independent samples of approximately 3,780 athletes. Exploratory factor analyses (FA) for a two-factor solution were conducted with ImPACT composite scores within each of the five groups. Post-Concussion Symptom Scale (PCSS) scores were included, with the expectation they would load on a third, unique factor. Results All five samples met assumptions for FA (KMO Measure of Sampling Adequacy above.600), and all five analyses yielded the same "memory" and "speed" two-factor structure. Visual Motor Speed and Reaction Time loaded on the first "Speed" factor and Verbal and Visual Memory loaded on a second "Memory" factor. The PCSS scores loaded on a third, unique "symptom" factor. Conclusion Replication of the two-factor structure for ImPACT in a five large high school sample further validates the model. Given that both visual and verbal memory involve encoding of information presented visually, use of a "memory" factor may improve interpretation of ImPACT scores. Similarly, similarities between constructs measuring speed of responding (Reaction Time) and speed of processing (Visual Motor Processing Speed) may be best explained using a "speed" factor. [ABSTRACT FROM AUTHOR]

Published
2019
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27. Dependence on plasma shape and plasma fueling for small edge-localized mode regimes in TCV and ASDEX Upgrade

Author

V. Piergotti, F. Pesamosca, Bogdan Hnat, A. Sperduti, A. Krivska, J. Vicente, Panagiotis Tolias, Emanuele Poli, Matthias Hoelzl, Benedikt Geiger, A. Jardin, J. Ayllon-Guerola, G. Apruzzese, T. Lunt, J. Galdon-Quiroga, Riccardo Maggiora, M. Tardocchi, M. Koubiti, T. Jonsson, Bruce Lipschultz, P. Innocente, A. Gude, I Miron, M. G. Dunne, G. F. Harrer, A. Moro, A. Iantchenko, K. Galazka, P. Poloskei, K. Bogar, Roberto Ambrosino, G. Ferr, Vladimir E. Moiseenko, Istvan Cziegler, L. Guimarais, S. Vartanian, B. Erds, G. Pucella, V. Bobkov, James Buchanan, Raffaele Albanese, Harry M. Meyer, D. Boeyaert, G. F. Matthews, Eva Macusova, V. S. Marchenko, R. Zagórski, J. Buermans, A. Fil, W. Zhang, Giuseppe Gorini, B. Tal, D. Zaloga, Hugo Bufferand, A. Romano, L. Colas, J. Zebrowski, M. Weiland, L. Barrera-Orte, Matjaž Panjan, A.J. Thornton, E. Wolfrum, Miglena Dimitrova, R. M. McDermott, R. Lombroni, O. Tudisco, F. Reimold, E. R. Solano, X. Feng, Petra Bilkova, M. Groth, E. Alessi, D. S. Gahle, Olivier Février, I. Voitsekhovitch, Matthew Carr, A. Bock, O. Vasilovici, C. Ham, Lorenzo Figini, Guglielmo Rubinacci, Peter Lang, Pierre Manas, S. Costea, A. Kirk, F. Causa, J. Adamek, Vu N. M. T., M. Cavedon, O. Grover, Geert Verdoolaege, M. Spolaore, L. Sanchis-Sanchez, P. Bohm, P. V. Kazantzidis, Sarah Newton, M. Tomes, M.-L. Mayoral, J. R. Harrison, C. Mazzotta, H. Reimerdes, Jorge Morales, D. Brunetti, J. Gonzalez-Martin, Tomas Markovic, S. S. Henderson, D. Ricci, J. Juul Rasmussen, F. Janky, S. Saarelma, Z. Popovic, C. Tsironis, J. J. Rasmussen, S. K. Hansen, Sandra C. Chapman, Volker Naulin, H. Arnichand, Roberto Paccagnella, M. Faitsch, Anders Nielsen, M. Kong, V. Igochine, C. Piron, C. Bowman, Jorge Ferreira, D. Sytnykov, K. G. McClements, Olivier Sauter, Ondrej Ficker, Matthias Wiesenberger, T. Ravensbergen, C. Reux, Irena Ivanova-Stanik, Dirk Reiser, M. Bernert, M. Vallar, J-M Moret, M. Gruca, D. I. Refy, P. Cano Megias, Benoit Labit, M. Schubert, Giuliana Sias, O. Bogar, P. J. Mc Carthy, I. Faust, Gergely Papp, F. Matos, J. Garcia, C. Marini, E. L. Sorokovoy, Dimitri Voltolina, George Wilkie, J. M. Santos, R. R. Sheeba, Vladimir Weinzettl, Sergei Kasilov, J. Cerovsky, Matteo Agostini, G. Tardini, Laurie Porte, F. Dolizy, L. Gil, Matthias Komm, A. Dal Molin, B. Sieglin, Roch Kwiatkowski, M. C. C Messmer, Toke Koldborg Jensen, Vinodh Bandaru, Ben F. McMillan, Alessandra Fanni, Daniele Carnevale, Shimpei Futatani, D. P. Coster, V. Korovin, S. E. Sharapov, Patrik Ollus, J. Gath, A. Czarnecka, D. Gallart, M. Peterka, P. Vallejos Olivares, Jernej Kovacic, Nicolas Fedorczak, Silvio Ceccuzzi, L. Piron, J. Rosato, G. Kocsis, Stefan Kragh Nielsen, M. Garcia-Mu oz, Radomir Panek, S. F. Smith, Paolo Bettini, A. Mariani, R. Dejarnac, Lorenzo Frassinetti, D. Douai, L. Garzotti, H. J. Sun, C.K. Tsui, N. den Harder, John Elmerdahl Olsen, F. Bombarda, M. Francesco, Piero Martin, D. Hogeweij, P. Blanchard, F. Bouquey, Gabor Por, Luca Boncagni, Carlo Sozzi, Martin Hron, P. A. Schneider, V. P. Loschiavo, David Terranova, D. Aguiam, D. Choi, M. Gobbin, D. Iglesias, M. Reich, G. Avdeeva, A. Gallo, O. Biletskyi, M. Aradi, F. Liu, M. Griener, Antti Snicker, L. Kripner, Jérôme Bucalossi, L. Hesslow, Nick Walkden, M. Rodriguez-Ramos, T. C. Blanken, Cristian Galperti, F. Jaulmes, G. Calabr, G.A. Rattá, W. Bin, S. Garavaglia, V. Plyusnin, Andreas Frank Martitsch, A. Zisis, Rita Lorenzini, Duccio Testa, M. Passeri, Ola Embréus, N. Krawczyk, K. Särkimäki, Davide Galassi, D. Samaddar, M. Oberkofler, E. Seliunin, D. Brida, P. Buratti, F. Nabais, J. Ongena, J. Likonen, Yann Camenen, M. J. Mantsinen, F. Carpanese, S. Wiesen, P. Piovesan, Mirko Salewski, J. Hawke, Florian Laggner, R. Bilato, M. Wischmeier, L. Pigatto, G. I. Pokol, G. Giruzzi, Jens Madsen, D. Gadariya, L. Stipani, Christian Theiler, J. Stober, Michael Barnes, Timothy Goodman, R. D. Nem, J. J. Dominguez-Palacios Duran, F. Militello, Y. Kulyk, D. J. Cruz Zabala, A. Drenik, P. Manz, M. Scheffer, V. Pericoli Radolfini, B. Tilia, John Omotani, B. Vanovac, B. S. Schneider, E. Fable, Jakub Urban, T. Gyergyek, A. N. Karpushov, M. Farnik, Jakub Seidl, Christopher G. Albert, Antoine Merle, A. Cathey, D. A. Ryan, Sergio Galeani, R. Scannell, A. Havranek, G. de Carolis, C. Soria-Hoyo, S. Gibson, D. Carralero, D. Meshcheriakov, Morten Stejner, B. P. Duval, Francesco Cordella, Mitja Kelemen, Svetlana V. Ratynskaia, Stefano Coda, L. Calacci, C. Cianfarani, Faa Federico Felici, A. C. A. Figueiredo, L. Panaccione, E. Viezzer, Fabio Villone, Daniele Milanesio, Winfried Kernbichler, Mario Sassano, A. Teplukhina, S. Zoletnik, L. Laguardia, P. Molina Cabrera, Taina Kurki-Suonio, D. Micheletti, P. Zanca, Daniel Dunai, S. Feng, J. Decker, Stylianos Varoutis, Lorella Carraro, M. Wensing, Gustavo Granucci, Artur Palha, A. Kappatou, J. Garcia-Lopez, Felix I. Parra, Ye. O. Kazakov, S. Brezinsek, Didier Mazon, A. Lahtinen, I. Paradela Perez, P. Chmielewski, L. Giacomelli, Alessandro Pau, Gianluca Spizzo, R. Delogu, R. J. Akers, H. De Oliveira, Petr Vondracek, F. P. Orsitto, J. Hobirk, L. Xiang, A. Burckhart, B. Maljaars, V. Petrzilka, Ocleto D'Arcangelo, P. David, D. Grekov, Tamás Szepesi, Y. Andr be, P. Hacek, M. Toscano-Jimenez, T. Pütterich, L. Cordaro, V. Nikolaeva, F. Orain, M. Rabinski, C. Ionita-Schrittwieser, T. Tala, Maria Ester Puiatti, A. Casolari, T. Happel, Pär Strand, Benjamin Daniel Dudson, P. Mantica, Z. Huang, D. Colette, G. Ciraolo, Jan Mlynar, W. Suttrop, C. Meineri, J. Horacek, Seppo Sipilä, M. Gospodarczyk, S. Mastrostefano, Jesús Vega, Antti Hakola, Kevin Verhaegh, Roman Schrittwieser, C. Marchetto, M. Willensdorfer, Jari Varje, D. C. van Vugt, J. Faustin, Mathias Hoppe, M. Dreval, A. Perek, C. Angioni, Laure Vermare, U. A. Sheikh, J. F. Rivero-Rodriguez, G. Rubino, S.N. Reznik, Tsv K Popov, S. Nowak, A. S. Jacobsen, J. R. Martin Solis, David Moulton, Heinz Isliker, K. Wu, Anna Salmi, F. Nespoli, S. Elmore, O. Kudlacek, A. Kallenbach, Rok Zaplotnik, D. L. Keeling, L. Giannone, M. Maraschek, Carlos B. da Silva, F. Hitzler, M. Valovic, M. W. Jakubowski, L. Gabellieri, Jozef Varju, Marco Cecconello, M. Valisa, Vlado Menkovski, Gábor Cseh, E. Thoren, T. Eich, R. Coelho, F. Bagnato, Matteo Zuin, Alexander Kendl, G. Rocchi, G. Pautasso, D. Naydenkova, R. O. Pavlichenko, M. Fontana, Lionello Marrelli, Tommaso Bolzonella, Nicola Vianello, Pascale Hennequin, R. Ochoukov, Tom Wauters, Christian Hopf, Ch. Fuchs, E. Giovannozzi, Fulvio Auriemma, Roberto Maurizio, Stefan Buller, Massimo Nocente, K. Krieger, G. Grenfell, N. Rispoli, R. Dux, Barbara Cannas, Laboratoire de Physique des Plasmas (LPP), Université Paris-Saclay-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-École polytechnique (X)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Labit, B., Eich, T., Harrer, G. F., Wolfrum, E., Bernert, M., Dunne, M. G., Frassinetti, L., Hennequin, P., Maurizio, R., Merle, A., Meyer, H., Saarelma, S., Sheikh, U., Adamek, J., Agostini, M., Aguiam, D., Akers, R., Albanese, R., Albert, C., Alessi, E., Ambrosino, R., Andr be, Y., Angioni, C., Apruzzese, G., Aradi, M., Arnichand, H., Auriemma, F., Avdeeva, G., Ayllon-Guerola, J. M., Bagnato, F., Bandaru, V. K., Barnes, M., Barrera-Orte, L., Bettini, P., Bilato, R., Biletskyi, O., Bilkova, P., Bin, W., Blanchard, P., Blanken, T., Bobkov, V., Bock, A., Boeyaert, D., Bogar, K., Bogar, O., Bohm, P., Bolzonella, T., Bombarda, F., Boncagni, L., Bouquey, F., Bowman, C., Brezinsek, S., Brida, D., Brunetti, D., Bucalossi, J., Buchanan, J., Buermans, J., Bufferand, H., Buller, S., Buratti, P., Burckhart, A., Calabr, G., Calacci, L., Camenen, Y., Cannas, B., Cano Megias, P., Carnevale, D., Carpanese, F., Carr, M., Carralero, D., Carraro, L., Casolari, A., Cathey, A., Causa, F., Cavedon, M., Cecconello, M., Ceccuzzi, S., Cerovsky, J., Chapman, S., Chmielewski, P., Choi, D., Cianfarani, C., Ciraolo, G., Coda, S., Coelho, R., Colas, L., Colette, D., Cordaro, L., Cordella, F., Costea, S., Coster, D., Cruz Zabala, D. J., Cseh, G., Czarnecka, A., Cziegler, I., D'Arcangelo, O., Dal Molin, A., David, P., De Carolis, G., De Oliveira, H., Decker, J., Dejarnac, R., Delogu, R., Den Harder, N., Dimitrova, M., Dolizy, F., Dominguez-Palacios Duran, J. J., Douai, D., Drenik, A., Dreval, M., Dudson, B., Dunai, D., Duval, B. P., Dux, R., Elmore, S., Embreus, O., Erds, B., Fable, E., Faitsch, M., Fanni, A., Farnik, M., Faust, I., Faustin, J., Fedorczak, N., Felici, F., Feng, S., Feng, X., Ferreira, J., Ferr, G., Fevrier, O., Ficker, O., Figini, L., Figueiredo, A., Fil, A., Fontana, M., Francesco, M., Fuchs, C., Futatani, S., Gabellieri, L., Gadariya, D., Gahle, D., Galassi, D., Galazka, K., Galdon-Quiroga, J., Galeani, S., Gallart, D., Gallo, A., Galperti, C., Garavaglia, S., Garcia, J., Garcia-Lopez, J., Garcia-Mu oz, M., Garzotti, L., Gath, J., Geiger, B., Giacomelli, L., Giannone, L., Gibson, S., Gil, L., Giovannozzi, E., Giruzzi, G., Gobbin, M., Gonzalez-Martin, J., Goodman, T. P., Gorini, G., Gospodarczyk, M., Granucci, G., Grekov, D., Grenfell, G., Griener, M., Groth, M., Grover, O., Gruca, M., Gude, A., Guimarais, L., Gyergyek, T., Hacek, P., Hakola, A., Ham, C., Happel, T., Harrison, J., Havranek, A., Hawke, J., Henderson, S., Hesslow, L., Hitzler, F., Hnat, B., Hobirk, J., Hoelzl, M., Hogeweij, D., Hopf, C., Hoppe, M., Horacek, J., Hron, M., Huang, Z., Iantchenko, A., Iglesias, D., Igochine, V., Innocente, P., Ionita-Schrittwieser, C., Isliker, H., Ivanova-Stanik, I., Jacobsen, A., Jakubowski, M., Janky, F., Jardin, A., Jaulmes, F., Jensen, T., Jonsson, T., Kallenbach, A., Kappatou, A., Karpushov, A., Kasilov, S., Kazakov, Y., Kazantzidis, P. V., Keeling, D., Kelemen, M., Kendl, A., Kernbichler, W., Kirk, A., Kocsis, G., Komm, M., Kong, M., Korovin, V., Koubiti, M., Kovacic, J., Krawczyk, N., Krieger, K., Kripner, L., Krivska, A., Kudlacek, O., Kulyk, Y., Kurki-Suonio, T., Kwiatkowski, R., Laggner, F., Laguardia, L., Lahtinen, A., Lang, P., Likonen, J., Lipschultz, B., Liu, F., Lombroni, R., Lorenzini, R., Loschiavo, V. P., Lunt, T., Macusova, E., Madsen, J., Maggiora, R., Maljaars, B., Manas, P., Mantica, P., Mantsinen, M. J., Manz, P., Maraschek, M., Marchenko, V., Marchetto, C., Mariani, A., Marini, C., Markovic, T., Marrelli, L., Martin, P., Martin Solis, J. R., Martitsch, A., Mastrostefano, S., Matos, F., Matthews, G., Mayoral, M. -L., Mazon, D., Mazzotta, C., Mc Carthy, P., Mcclements, K., Mcdermott, R., Mcmillan, B., Meineri, C., Menkovski, V., Meshcheriakov, D., Messmer, M., Micheletti, D., Milanesio, D., Militello, F., Miron, I. G., Mlynar, J., Moiseenko, V., Molina Cabrera, P. A., Morales, J., Moret, J. -M., Moro, A., Moulton, D., Nabais, F., Naulin, V., Naydenkova, D., Nem, R. D., Nespoli, F., Newton, S., Nielsen, A. H., Nielsen, S. K., Nikolaeva, V., Nocente, M., Nowak, S., Oberkofler, M., Ochoukov, R., Ollus, P., Olsen, J., Omotani, J., Ongena, J., Orain, F., Orsitto, F. P., Paccagnella, R., Palha, A., Panaccione, L., Panek, R., Panjan, M., Papp, G., Paradela Perez, I., Parra, F., Passeri, M., Pau, A., Pautasso, G., Pavlichenko, R., Perek, A., Pericoli Radolfini, V., Pesamosca, F., Peterka, M., Petrzilka, V., Piergotti, V., Pigatto, L., Piovesan, P., Piron, C., Piron, L., Plyusnin, V., Pokol, G., Poli, E., Poloskei, P., Popov, T., Popovic, Z., Por, G., Porte, L., Pucella, G., Puiatti, M. E., Putterich, T., Rabinski, M., Juul Rasmussen, J., Rasmussen, J., Ratta, G. A., Ratynskaia, S., Ravensbergen, T., Refy, D., Reich, M., Reimerdes, H., Reimold, F., Reiser, D., Reux, C., Reznik, S., Ricci, D., Rispoli, N., Rivero-Rodriguez, J. F., Rocchi, G., Rodriguez-Ramos, M., Romano, A., Rosato, J., Rubinacci, G., Rubino, G., Ryan, D. A., Salewski, M., Salmi, A., Samaddar, D., Sanchis-Sanchez, L., Santos, J., Sarkimaki, K., Sassano, M., Sauter, O., Scannell, R., Scheffer, M., Schneider, B. S., Schneider, P., Schrittwieser, R., Schubert, M., Seidl, J., Seliunin, E., Sharapov, S., Sheeba, R. R., Sias, G., Sieglin, B., Silva, C., Sipila, S., Smith, S., Snicker, A., Solano, E. R., Hansen, S. K., Soria-Hoyo, C., Sorokovoy, E., Sozzi, C., Sperduti, A., Spizzo, G., Spolaore, M., Stejner, M., Stipani, L., Stober, J., Strand, P., Sun, H., Suttrop, W., Sytnykov, D., Szepesi, T., Tal, B., Tala, T., Tardini, G., Tardocchi, M., Teplukhina, A., Terranova, D., Testa, D., Theiler, C., Thoren, E., Thornton, A., Tilia, B., Tolias, P., Tomes, M., Toscano-Jimenez, M., Tsironis, C., Tsui, C., Tudisco, O., Urban, J., Valisa, M., Vallar, M., Vallejos Olivares, P., Valovic, M., Van Vugt, D., Vanovac, B., Varje, J., Varju, J., Varoutis, S., Vartanian, S., Vasilovici, O., Vega, J., Verdoolaege, G., Verhaegh, K., Vermare, L., Vianello, N., Vicente, J., Viezzer, E., Villone, F., Voitsekhovitch, I., Voltolina, D., Vondracek, P., Vu, N. M. T., Walkden, N., Wauters, T., Weiland, M., Weinzettl, V., Wensing, M., Wiesen, S., Wiesenberger, M., Wilkie, G., Willensdorfer, M., Wischmeier, M., Wu, K., Xiang, L., Zagorski, R., Zaloga, D., Zanca, P., Zaplotnik, R., Zebrowski, J., Zhang, W., Zisis, A., Zoletnik, S., Zuin, M., Swiss Federal Institute of Technology Lausanne, Max-Planck-Institut für Plasmaphysik, Vienna University of Technology, KTH Royal Institute of Technology, Université Paris-Saclay, JET, Czech Academy of Sciences, National Research Council of Italy, University of Lisbon, University of Naples Federico II, Graz University of Technology, University of Naples Parthenope, Agenzia nazionale per le nuove tecnologie, l'energia e lo sviluppo economico sostenibile, Danmarks Tekniske Universitet, University of Seville, University of Oxford, EUROfusion Programme Management Unit, National Science Center Kharkov Institute of Physics and Technology, Eindhoven University of Technology, Forschungszentrum Jülich, CEA, University of York, Royal Military Academy, Chalmers University of Technology, Tuscia University, Università di Roma Tor Vergata, CNRS, University of Cagliari, CIEMAT, Uppsala University, University of Warwick, Soltan Institute for Nuclear Studies, University of Innsbruck, Hungarian Academy of Sciences, Budapest University of Technology and Economics, Durham University, BarcelonaTech, University of Strathclyde, Barcelona Supercomputing Center, University of Milan - Bicocca, Karlsruhe Institute of Technology, Fusion and Plasma Physics, J. Stefan Institute, VTT Technical Research Centre of Finland, Dutch Institute for Fundamental Energy Research, Aristotle University of Thessaloniki, National Technical University of Athens, National Centre for Nuclear Research, University of Helsinki, Université Côte d'Azur, Polytechnic University of Turin, NASU - Institute of Nuclear Research, University of Cassino and Southern Lazio, University College Cork, National Institute for Laser, Plasma and Radiation Physics, Department of Applied Physics, Sofia University St. Kliment Ohridski, Ghent University, Aalto-yliopisto, Aalto University, Labit, B, Eich, T, Harrer, G, Wolfrum, E, Bernert, M, Dunne, M, Frassinetti, L, Hennequin, P, Maurizio, R, Merle, A, Meyer, H, Saarelma, S, Sheikh, U, Adamek, J, Agostini, M, Aguiam, D, Akers, R, Albanese, R, Albert, C, Alessi, E, Ambrosino, R, Andr be, Y, Angioni, C, Apruzzese, G, Aradi, M, Arnichand, H, Auriemma, F, Avdeeva, G, Ayllon-Guerola, J, Bagnato, F, Bandaru, V, Barnes, M, Barrera-Orte, L, Bettini, P, Bilato, R, Biletskyi, O, Bilkova, P, Bin, W, Blanchard, P, Blanken, T, Bobkov, V, Bock, A, Boeyaert, D, Bogar, K, Bogar, O, Bohm, P, Bolzonella, T, Bombarda, F, Boncagni, L, Bouquey, F, Bowman, C, Brezinsek, S, Brida, D, Brunetti, D, Bucalossi, J, Buchanan, J, Buermans, J, Bufferand, H, Buller, S, Buratti, P, Burckhart, A, Calabr, G, Calacci, L, Camenen, Y, Cannas, B, Cano Megias, P, Carnevale, D, Carpanese, F, Carr, M, Carralero, D, Carraro, L, Casolari, A, Cathey, A, Causa, F, Cavedon, M, Cecconello, M, Ceccuzzi, S, Cerovsky, J, Chapman, S, Chmielewski, P, Choi, D, Cianfarani, C, Ciraolo, G, Coda, S, Coelho, R, Colas, L, Colette, D, Cordaro, L, Cordella, F, Costea, S, Coster, D, Cruz Zabala, D, Cseh, G, Czarnecka, A, Cziegler, I, D'Arcangelo, O, Dal Molin, A, David, P, De Carolis, G, De Oliveira, H, Decker, J, Dejarnac, R, Delogu, R, Den Harder, N, Dimitrova, M, Dolizy, F, Dominguez-Palacios Duran, J, Douai, D, Drenik, A, Dreval, M, Dudson, B, Dunai, D, Duval, B, Dux, R, Elmore, S, Embreus, O, Erds, B, Fable, E, Faitsch, M, Fanni, A, Farnik, M, Faust, I, Faustin, J, Fedorczak, N, Felici, F, Feng, S, Feng, X, Ferreira, J, Ferr, G, Fevrier, O, Ficker, O, Figini, L, Figueiredo, A, Fil, A, Fontana, M, Francesco, M, Fuchs, C, Futatani, S, Gabellieri, L, Gadariya, D, Gahle, D, Galassi, D, Galazka, K, Galdon-Quiroga, J, Galeani, S, Gallart, D, Gallo, A, Galperti, C, Garavaglia, S, Garcia, J, Garcia-Lopez, J, Garcia-Mu oz, M, Garzotti, L, Gath, J, Geiger, B, Giacomelli, L, Giannone, L, Gibson, S, Gil, L, Giovannozzi, E, Giruzzi, G, Gobbin, M, Gonzalez-Martin, J, Goodman, T, Gorini, G, Gospodarczyk, M, Granucci, G, Grekov, D, Grenfell, G, Griener, M, Groth, M, Grover, O, Gruca, M, Gude, A, Guimarais, L, Gyergyek, T, Hacek, P, Hakola, A, Ham, C, Happel, T, Harrison, J, Havranek, A, Hawke, J, Henderson, S, Hesslow, L, Hitzler, F, Hnat, B, Hobirk, J, Hoelzl, M, Hogeweij, D, Hopf, C, Hoppe, M, Horacek, J, Hron, M, Huang, Z, Iantchenko, A, Iglesias, D, Igochine, V, Innocente, P, Ionita-Schrittwieser, C, Isliker, H, Ivanova-Stanik, I, Jacobsen, A, Jakubowski, M, Janky, F, Jardin, A, Jaulmes, F, Jensen, T, Jonsson, T, Kallenbach, A, Kappatou, A, Karpushov, A, Kasilov, S, Kazakov, Y, Kazantzidis, P, Keeling, D, Kelemen, M, Kendl, A, Kernbichler, W, Kirk, A, Kocsis, G, Komm, M, Kong, M, Korovin, V, Koubiti, M, Kovacic, J, Krawczyk, N, Krieger, K, Kripner, L, Krivska, A, Kudlacek, O, Kulyk, Y, Kurki-Suonio, T, Kwiatkowski, R, Laggner, F, Laguardia, L, Lahtinen, A, Lang, P, Likonen, J, Lipschultz, B, Liu, F, Lombroni, R, Lorenzini, R, Loschiavo, V, Lunt, T, Macusova, E, Madsen, J, Maggiora, R, Maljaars, B, Manas, P, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Marchenko, V, Marchetto, C, Mariani, A, Marini, C, Markovic, T, Marrelli, L, Martin, P, Martin Solis, J, Martitsch, A, Mastrostefano, S, Matos, F, Matthews, G, Mayoral, M, Mazon, D, Mazzotta, C, Mc Carthy, P, Mcclements, K, Mcdermott, R, Mcmillan, B, Meineri, C, Menkovski, V, Meshcheriakov, D, Messmer, M, Micheletti, D, Milanesio, D, Militello, F, Miron, I, Mlynar, J, Moiseenko, V, Molina Cabrera, P, Morales, J, Moret, J, Moro, A, Moulton, D, Nabais, F, Naulin, V, Naydenkova, D, Nem, R, Nespoli, F, Newton, S, Nielsen, A, Nielsen, S, Nikolaeva, V, Nocente, M, Nowak, S, Oberkofler, M, Ochoukov, R, Ollus, P, Olsen, J, Omotani, J, Ongena, J, Orain, F, Orsitto, F, Paccagnella, R, Palha, A, Panaccione, L, Panek, R, Panjan, M, Papp, G, Paradela Perez, I, Parra, F, Passeri, M, Pau, A, Pautasso, G, Pavlichenko, R, Perek, A, Pericoli Radolfini, V, Pesamosca, F, Peterka, M, Petrzilka, V, Piergotti, V, Pigatto, L, Piovesan, P, Piron, C, Piron, L, Plyusnin, V, Pokol, G, Poli, E, Poloskei, P, Popov, T, Popovic, Z, Por, G, Porte, L, Pucella, G, Puiatti, M, Putterich, T, Rabinski, M, Juul Rasmussen, J, Rasmussen, J, Ratta, G, Ratynskaia, S, Ravensbergen, T, Refy, D, Reich, M, Reimerdes, H, Reimold, F, Reiser, D, Reux, C, Reznik, S, Ricci, D, Rispoli, N, Rivero-Rodriguez, J, Rocchi, G, Rodriguez-Ramos, M, Romano, A, Rosato, J, Rubinacci, G, Rubino, G, Ryan, D, Salewski, M, Salmi, A, Samaddar, D, Sanchis-Sanchez, L, Santos, J, Sarkimaki, K, Sassano, M, Sauter, O, Scannell, R, Scheffer, M, Schneider, B, Schneider, P, Schrittwieser, R, Schubert, M, Seidl, J, Seliunin, E, Sharapov, S, Sheeba, R, Sias, G, Sieglin, B, Silva, C, Sipila, S, Smith, S, Snicker, A, Solano, E, Hansen, S, Soria-Hoyo, C, Sorokovoy, E, Sozzi, C, Sperduti, A, Spizzo, G, Spolaore, M, Stejner, M, Stipani, L, Stober, J, Strand, P, Sun, H, Suttrop, W, Sytnykov, D, Szepesi, T, Tal, B, Tala, T, Tardini, G, Tardocchi, M, Teplukhina, A, Terranova, D, Testa, D, Theiler, C, Thoren, E, Thornton, A, Tilia, B, Tolias, P, Tomes, M, Toscano-Jimenez, M, Tsironis, C, Tsui, C, Tudisco, O, Urban, J, Valisa, M, Vallar, M, Vallejos Olivares, P, Valovic, M, Van Vugt, D, Vanovac, B, Varje, J, Varju, J, Varoutis, S, Vartanian, S, Vasilovici, O, Vega, J, Verdoolaege, G, Verhaegh, K, Vermare, L, Vianello, N, Vicente, J, Viezzer, E, Villone, F, Voitsekhovitch, I, Voltolina, D, Vondracek, P, Vu, N, Walkden, N, Wauters, T, Weiland, M, Weinzettl, V, Wensing, M, Wiesen, S, Wiesenberger, M, Wilkie, G, Willensdorfer, M, Wischmeier, M, Wu, K, Xiang, L, Zagorski, R, Zaloga, D, Zanca, P, Zaplotnik, R, Zebrowski, J, Zhang, W, Zisis, A, Zoletnik, S, Zuin, M, Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. ANT - Advanced Nuclear Technologies Research Group, Control Systems Technology, Science and Technology of Nuclear Fusion, Data Mining, Sensorics for fusion reactors, and Magneto-Hydro-Dynamic Stability of Fusion Plasmas

Subjects
Nuclear and High Energy Physics, Settore ING-INF/04, Work package, grassy ELM, ballooning modes, Nuclear physics, 01 natural sciences, Flattening, Ballooning, 010305 fluids & plasmas, grassy ELMs, separatrix density, ASDEX Upgrade, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], 0103 physical sciences, 010306 general physics, Edge-localized mode, QC, H-mode, plasma triangularity, type-II ELMs, Physics, Física [Àrees temàtiques de la UPC], type-II ELM, Plasma, Condensed Matter Physics, Null (physics), Shear (sheet metal), Física nuclear, Atomic physics, ballooning mode
Abstract

Within the EUROfusion MST1 work package, a series of experiments has been conducted on AUG and TCV devices to disentangle the role of plasma fueling and plasma shape for the onset of small ELM regimes. On both devices, small ELM regimes with high confinement are achieved if and only if two conditions are fulfilled at the same time. Firstly, the plasma density at the separatrix must be large enough (), leading to a pressure profile flattening at the separatrix, which stabilizes type-I ELMs. Secondly, the magnetic configuration has to be close to a double null (DN), leading to a reduction of the magnetic shear in the extreme vicinity of the separatrix. As a consequence, its stabilizing effect on ballooning modes is weakened. Peer Reviewed Article escrit per 365 autors/autores: Labit, B.; Eich, T.; Harrer, G. F.; Wolfrum, E.; Bernert, M.; Dunne, M. G.; Frassinetti, L.; Hennequin, P.; Maurizio, R.; Merle, A.; Meyer, H.; Saarelma, S.; Sheikh, U.; Adamek, J.; Agostini, M.; Aguiam, D.; Akers, R.; Albanese, R.; Albert, C.; Alessi, E.; Ambrosino, R.; Andr be, Y.; Angioni, C.; Apruzzese, G.; Aradi, M.; Arnichand, H.; Auriemma, F.; Avdeeva, G.; Ayllon-Guerola, J. M.; Bagnato, F.; Bandaru, V. K.; Barnes, M.; Barrera-Orte, L.; Bettini, P.; Bilato, R.; Biletskyi, O.; Bilkova, P.; Bin, W.; Blanchard, P.; Blanken, T.; Bobkov, V.; Bock, A.; Boeyaert, D.; Bogar, K.; Bogar, O.; Bohm, P.; Bolzonella, T.; Bombarda, F.; Boncagni, L.; Bouquey, F.; Bowman, C.; Brezinsek, S.; Brida, D.; Brunetti, D.; Bucalossi, J.; Buchanan, J.; Buermans, J.; Bufferand, H.; Buller, S.; Buratti, P.; Burckhart, A.; Calabr, G.; Calacci, L.; Camenen, Y.; Cannas, B.; Cano Megías, P.; Carnevale, D.; Carpanese, F.; Carr, M.; Carralero, D.; Carraro, L.; Casolari, A.; Cathey, A.; Causa, F.; Cavedon, M.; Cecconello, M.; Ceccuzzi, S.; Cerovsky, J.; Chapman, S.; Chmielewski, P.; Choi, D.; Cianfarani, C.; Ciraolo, G.; Coda, S.; Coelho, R.; Colas, L.; Colette, D.; Cordaro, L.; Cordella, F.; Costea, S.; Coster, D.; Cruz Zabala, D. J.; Cseh, G.; Czarnecka, A.; Cziegler, I.; D’Arcangelo, O.; Dal Molin, A.; David, P.; De Carolis, G.; De Oliveira, H.; Decker, J.; Dejarnac, R.; Delogu, R.; Den Harder, N.; Dimitrova, M.; Dolizy, F.; Domínguez-Palacios Durán, J. J.; Douai, D.; Drenik, A.; Dreval, M.; Dudson, B.; Dunai, D.; Duval, B. P.; Dux, R.; Elmore, S.; Embréus, O.; Erds, B.; Fable, E.; Faitsch, M.; Fanni, A.; Farnik, M.; Faust, I.; Faustin, J.; Fedorczak, N.; Felici, F.; Feng, S.; Feng, X.; Ferreira, J.; Ferr, G.; Février, O.; Ficker, O.; Figini, L.; Figueiredo, A.; Fil, A.; Fontana, M.; Francesco, M.; Fuchs, C.; Futatani, S.; Gabellieri, L.; Gadariya, D.; Gahle, D.; Galassi, D.; Gałązka, K.; Galdon-Quiroga, J.; Galeani, S.; Gallart, D.; Gallo, A.; Galperti, C.; Garavaglia, S.; Garcia, J.; Garcia-Lopez, J.; Garcia-Mu oz, M.; Garzotti, L.; Gath, J.; Geiger, B.; Giacomelli, L.; Giannone, L.; Gibson, S.; Gil, L.; Giovannozzi, E.; Giruzzi, G.; Gobbin, M.; Gonzalez-Martin, J.; Goodman, T. P.; Gorini, G.; Gospodarczyk, M.; Granucci, G.; Grekov, D. 1; Grenfell, G.; Griener, M.; Groth, M.; Grover, O.; Gruca, M.; Gude, A.; Guimarais, L.; Gyergyek, T.; Hacek, P.; Hakola, A.; Ham, C.; Happel, T.; Harrison, J.; Havranek, A.; Hawke, J.; Henderson, S.; Hesslow, L.; Hitzler, F.; Hnat, B.; Hobirk, J.; Hoelzl, M.; Hogeweij, D.; Hopf, C.; Hoppe, M.; Horacek, J.; Hron, M.; Huang, Z.; Iantchenko, A.; Iglesias, D.; Igochine, V.; Innocente, P.; Ionita-Schrittwieser, C.; Isliker, H.; Ivanova-Stanik, I.; Jacobsen, A.; Jakubowski, M.; Janky, F.; Jardin, A.; Jaulmes, F.; Jensen, T.; Jonsson, T.; Kallenbach, A.; Kappatou, A.; Karpushov, A.; Kasilov, S.; Kazakov, Y.; Kazantzidis, P. V.; Keeling, D.; Kelemen, M.; Kendl, A.; Kernbichler, W.; Kirk, A.; Kocsis, G.; Komm, M.; Kong, M.; Korovin, V.; Koubiti, M.; Kovacic, J.; Krawczyk, N.; Krieger, K.; Kripner, L.; Křivská, A.; Kudlacek, O.; Kulyk, Y.; Kurki-Suonio, T.; Kwiatkowski, R.; Laggner, F.; Laguardia, L.; Lahtinen, A.; Lang, P.; Likonen, J.; Lipschultz, B.; Liu, F.; Lombroni, R.; Lorenzini, R.; Loschiavo, V. P.; Lunt, T.; MacUsova, E.; Madsen, J.; Maggiora, R.; Maljaars, B.; Manas, P.; Mantica, P.; Mantsinen, M. J.; Manz, P.; Maraschek, M.; Marchenko, V.; Marchetto, C.; Mariani, A.; Marini, C.; Markovic, T.; Marrelli, L.; Martin, P.; Martín Solís, J. R.; Martitsch, A.; Mastrostefano, S.; Matos, F.; Matthews, G.; Mayoral, M.-L.; Mazon, D.; Mazzotta, C.; Mc Carthy, P.; McClements, K.; McDermott, R.; McMillan, B.; Meineri, C.; Menkovski, V.; Meshcheriakov, D.; Messmer, M.; Micheletti, D.; Milanesio, D.; Militello, F.; Miron, I. G.; Mlynar, J.; Moiseenko, V.; Molina Cabrera, P. A.; Morales, J.; Moret, J.-M.; Moro, A.; Moulton, D.; Nabais, F.; Naulin, V.; Naydenkova, D.; Nem, R. D.; Nespoli, F.; Newton, S.; Nielsen, A. H.; Nielsen, S. K.; Nikolaeva, V.; Nocente, M.; Nowak, S.; Oberkofler, M.; Ochoukov, R.; Ollus, P.; Olsen, J.; Omotani, J.; Ongena, J.; Orain, F.; Orsitto, F. P.; Paccagnella, R.; Palha, A.; Panaccione, L.; Panek, R.; Panjan, M.; Papp, G.; Paradela Perez, I.; Parra, F.; Passeri, M.; Pau, A.; Pautasso, G.; Pavlichenko, R.; Perek, A.; Pericoli Radolfini, V.; Pesamosca, F.; Peterka, M.; Petrzilka, V.; Piergotti, V.; Pigatto, L.; Piovesan, P.; Piron, C.; Piron, L.; Plyusnin, V.; Pokol, G.; Poli, E.; Pölöskei, P.; Popov, T.; Popovic, Z.; Pór, G.; Porte, L.; Pucella, G.; Puiatti, M. E.; Pütterich, T.; Rabinski, M.; Juul Rasmussen, J.; Rasmussen, J.; Rattá, G. A.; Ratynskaia, S.; Ravensbergen, T.; Réfy, D.; Reich, M.; Reimerdes, H.; Reimold, F.; Reiser, D.; Reux, C.; Reznik, S.; Ricci, D.; Rispoli, N.; Rivero-Rodriguez, J. F.; Rocchi, G.; Rodriguez-Ramos, M.; Romano, A.; Rosato, J.; Rubinacci, G.; Rubino, G.; Ryan, D. A.; Salewski, M.; Salmi, A.; Samaddar, D.; Sanchis-Sanchez, L.; Santos, J.; Särkimäki, K.; Sassano, M.; Sauter, O.; Scannell, R.; Scheffer, M.; Schneider, B. S.; Schneider, P.; Schrittwieser, R.; Schubert, M.; Seidl, J.; Seliunin, E.; Sharapov, S.; Sheeba, R. R.; Sias, G.; Sieglin, B.; Silva, C.; Sipilä, S.; Smith, S.; Snicker, A.; Solano, E. R.; Hansen, S. K.; Soria-Hoyo, C.; Sorokovoy, E.; Sozzi, C.; Sperduti, A.; Spizzo, G.; Spolaore, M.; Stejner, M.; Stipani, L.; Stober, J.; Strand, P.; Sun, H.; Suttrop, W.; Sytnykov, D.; Szepesi, T.; Tál, B.; Tala, T.; Tardini, G.; Tardocchi, M.; Teplukhina, A.; Terranova, D.; Testa, D.; Theiler, C.; Thorén, E.; Thornton, A.; Tilia, B.; Tolias, P.; Tomes, M.; Toscano-Jimenez, M.; Tsironis, C.; Tsui, C.; Tudisco, O.; Urban, J.; Valisa, M.; Vallar, M.; Vallejos Olivares, P.; Valovic, M.; Van Vugt, D.; Vanovac, B.; Varje, J.; Varju, J.; Varoutis, S. 1; Vartanian, S.; Vasilovici, O.; Vega, J.; Verdoolaege, G.; Verhaegh, K.; Vermare, L.; Vianello, N.; Vicente, J.; Viezzer, E.; Villone, F.; Voitsekhovitch, I.; Voltolina, D.; Vondracek, P.; Vu, N. M. T.; Walkden, N.; Wauters, T.; Weiland, M.; Weinzettl, V.; Wensing, M.; Wiesen, S.; Wiesenberger, M.; Wilkie, G.; Willensdorfer, M.; Wischmeier, M.; Wu, K.; Xiang, L.; Zagorski, R.; Zaloga, D.; Zanca, P.; Zaplotnik, R.; Zebrowski, J.; Zhang, W.; Zisis, A.; Zoletnik, S.; Zuin, M.

Published
2019

28. Experimental study of ELM induced fast-ion transport using passive FIDA spectroscopy at the ASDEX Upgrade tokamak

Author

A. Jansen van Vuuren, B. Geiger, P.A. Schneider, K. Bogar, P.Zs. Poloskei, A. Cathey, M. Hoelzl, A.S. Jacobsen, M. Cavedon, R. Dux, the ASDEX Upgrade Team, Jansen Van Vuuren, A, Geiger, B, Schneider, P, Bogar, K, Poloskei, P, Cathey, A, Hoelzl, M, Jacobsen, A, Cavedon, M, Dux, R, and ASDEX Upgrade Team, Max Planck Institute for Plasma Physics, Max Planck Society

Subjects
Physics, Nuclear and High Energy Physics, Tokamak, charge exchange, Condensed Matter Physics, 01 natural sciences, 010305 fluids & plasmas, law.invention, Nuclear physics, FIDA spectroscopy, ASDEX Upgrade, law, 0103 physical sciences, ELM, fast-ion, 010306 general physics, Spectroscopy, Ion transporter, Charge exchange
Abstract

Measurements using a recently installed edge fast-ion D-alpha (FIDA) diagnostic at the ASDEX Upgrade tokamak show a clear effect of edge localised modes (ELMs) on the passive FIDA signals. While a reduction in the passive FIDA emission is observed in the scrape-off layer (SOL) region, measurements close to the last closed flux surface show an increase in signals shortly after ELMs, followed by a decrease. The decrease provides a clear sign of fast-ion losses in the SOL, while the increase can be explained by an enhanced neutral density during ELMs inside the plasma. In addition, small ELMs are observed, which barely change the neutral density and plasma position but still cause significant changes in the passive FIDA signals. A comparison of the measurements with forward modelling shows that 60% to 80% of the fast ions are lost by ELMs outside the last closed flux surface. In addition, a 20% decrease of the fast-ion density in a range up to 4 cm within the last closed flux surface can be inferred. This range agrees well with the latest modelling results of ELMs using the non-linear MHD code JOREK and shows that less than 0.3% of all fast ions are lost by ELMs.

Published
2021

29. Concomitant Use of Oral Anticoagulants with Oral Dipeptidyl Peptidase-4 Inhibitors and Serious Bleeding Events.

Author

Pham Nguyen TP, Leonard CE, Brensinger CM, Bilker WB, Chung SP, Horn JR, Bogar K, Miano TA, and Hennessy S

Abstract

In a prior screening study, saxagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4i), was found to have an increased rate of serious bleeding when used concomitantly with several oral anticoagulants (OACs). We aimed to confirm or refute the associations between concomitant use of individual OACs and DPP-4is and serious bleeding in a large US database, using self-controlled case series (SCCS) and case-crossover (CCO) designs. The study population was eligible Medicare beneficiaries co-exposed to a DPP-4i (precipitant) and either an OAC (object drug) or lisinopril (negative control object drug) in 2016-2020. For the SCCS, we used conditional Poisson regression to estimate adjusted rate ratios (RRs) between each co-exposure (vs. not) and serious bleeding and divided the RR by the adjusted RR for the corresponding lisinopril + precipitant pair to obtain ratios of RRs (RRRs). For the CCO, we estimated the adjusted odds ratios (ORs) of exposure to the precipitant in the focal window vs. referent window using multivariable conditional logistic regression and divided the ORs in the object drug-exposed cases over the ORs in negative object drug-exposed cases to obtain the ratios of ORs (RORs). The adjusted RRRs for serious bleeding ranged from 0.32 (0.05-1.91) for apixaban/lisinopril + saxagliptin to 3.49 (1.29-9.48) for warfarin/lisinopril + linagliptin. The adjusted RORs ranged from 0.01 (0.00-0.20) for rivaroxaban/lisinopril + saxagliptin to 2.99 (0.74-12.11) for apixaban/lisinopril + linagliptin. While we could not confirm previously identified signals because of statistical imprecision, several numerically elevated estimates still warrant caution in concomitant use and further examination., (© 2024 The Author(s). Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.)

Published
2024
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30. Caregivers' depressive symptoms and eating disorder severity in adults with anorexia and bulimia nervosa.

Author

Kocsis-Bogar K, Ossege M, Aigner M, Wancata J, and Friedrich F

Abstract

Background: Negative affectivity of caregivers has been linked to difficulties in the caregiver-patient relationship and it is assumed to contribute to the maintenance of eating disorder (ED) symptoms., Aims: The present study investigated the relationship of patients' ED symptom severity to patients' and caregivers' depressive symptoms, and caregivers' involvement in a mixed sample of adult inpatients with anorexia (AN) and bulimia nervosa (BN), as well as their caregivers., Method: The Eating Disorder Examination and Beck Depression Inventory (BDI) were administered to 55 adult ED patients (26 AN and 29 BN), and the BDI as well as the Involvement Evaluation Questionnaire were filled in by one caregiver of each patient., Results: Our results showed caregivers' depressive symptoms to be significantly related to patients' ED symptom severity, however depressive symptoms and ED symptoms of patients were not related. No connection of involvement of caregivers and ED severity of patients was found. AN and BN patients did not significantly differ on ED severity or depressive symptoms. Caregivers of AN and BN patients did not differ significantly on depressive symptoms and involvement., Conclusions: Our results support the importance of mental health support for caregivers of adults with AN and BN.

Published
2024
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31. Health services provided at the time of abortion in the US: a scoping review of the qualitative and quantitative evidence.

Author

Mahoney KM, Bravo L, McAllister A, Bogar K, Hennessey S, Schreiber CA, and Abernathy A

Abstract

Objectives: While it is well documented that abortion access is associated with improved health, pregnancy-related, and socioeconomic outcomes, the association between abortion access and other reproductive health outcomes is less well described. Abortion-providing clinics also offer preventative reproductive health services. We conducted a scoping review to ascertain the extent to which preventive reproductive healthcare services (contraception, sexually transmitted infection testing and treatment, cervical cancer screening) are affected by abortion access in the United States., Methods: Researchers screened articles and extracted data from PubMed, Embase, Scopus and CINAHL. We excluded articles that did not link abortion to contraception, sexually transmitted infection testing and treatment and cervical cancer screening; or took place outside the US., Results: 5,359 papers were screened, 74 were included for full text review. Sixty-five were about contraception, seven on STIs, one on cervical cancer screening, and one on other services. The association between policies that restrict or protect abortion access and preventative health services has not been studied on a national scale. Drivers of variation were: insurance and billing policies; regulatory requirements of abortion-providing facilities, lack of staff training in clinics that did not specialize in abortion care; and limited follow up after abortion., Conclusions: Abortion--providing clinics are a highly utilized access point for reproductive health services. More research is needed to determine the public health impact of constrained abortion access on contraceptive use, STI rates and cervical cancer in regions where many abortion-providing clinics have closed., Implications: Attention should be paid to changing trends in contraceptive use, STI rates and cervical cancer as abortion-providing clinics close, this may reduce access to reproductive health services broadly., Competing Interests: Conflict of Interest: none

Published
2024
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32. Involvement, depressive symptoms, and their associations with problems and unmet needs in caregivers of adult eating disorder patients.

Author

Kocsis-Bogar K, Ossege M, Aigner M, Wancata J, and Friedrich F

Subjects
Humans, Adult, Caregivers, Depression, Inpatients, Feeding and Eating Disorders, Anorexia Nervosa
Abstract

Purpose: This study aimed to examine the most important problems and needs caregivers of adult inpatients with eating disorders (EDs) are confronted with in their everyday lives. A further aim was to investigate the associations between problems, needs, involvement, and depression in carers., Methods: Fifty-five caregivers of inpatients with EDs (26 anorexia nervosa, 29 bulimia nervosa) completed the Carers' Needs Assessment, Beck Depression Inventory, and the Involvement Evaluation Questionnaire. The relationships between variables were tested via multiple linear regressions and mediation analyses., Results: The most frequent problem reported by caregivers was a lack of information about the course and treatment of the illness and consequent disappointment, whereas their most frequently reported needs were different forms of information and counselling. Problems, unmet needs, and worrying were especially high in parents compared to other caregivers. Involvement mediated significantly between problems (b = 0.26, BCa CI [0.03, 0.49]) as well as unmet needs (b = 0.32, BCa CI [0.03, 0.59]) of caregivers and their depressive symptoms., Conclusion: Our findings underline the importance of including the problems and needs of caregivers of adult eating disorder patients in the planning of family and community interventions, to support their mental health., Level of Evidence: Level III: Evidence obtained from cohort or case-control analytic studies., (© 2023. The Author(s).)

Published
2023
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33. Adverse childhood experiences as risk factors for recurrent admissions in young psychiatric inpatients.

Author

Fellinger M, Knasmüller P, Kocsis-Bogar K, Wippel A, Fragner L, Mairhofer D, Hochgatterer P, and Aigner M

Abstract

Background: Patients who require psychiatric inpatient treatment early in life are a particularly at-risk population. Factors such as adverse childhood experiences (ACEs) are, however, not well studied in those requiring psychiatric inpatient treatment during both childhood or adolescence and adulthood. Thus, the aim of the current study was to investigate, in young adult inpatients, the risk factors for prior admissions in Child and Adolescent Psychiatry, with a focus on ACEs., Materials and Methods: An explorative population-based systematic chart investigation of psychiatric inpatients aged 18-25 was conducted at the University Hospital Tulln, Austria. Data analysis was done with descriptive methods and Pearson's chi- squared-, Fisher's exact-, Mann-Whitney- U -tests and predictive logistic regression models., Results: The sample comprised 390 inpatients (51.8% female), with an average age of 20 years at first psychiatric hospital admission. Those with a former child and adolescent psychiatry inpatient treatment (10.3%) were predominantly female (77.5%). Their number of documented ACEs was increased compared to those without former child and adolescent psychiatry admissions (2 vs 1.1), with up to twice as many experiences of family dysfunction, neglect or abuse. Sexual abuse (OR: 3.0), having been an adopted or fostered child (OR: 4.5), and female sex (OR: 3.0) were identified as main risk factors. Furthermore, former child and adolescent psychiatry inpatients suffered from higher rates of psychosomatic or personality disorders, comorbidities and functional impairment, and were readmitted twice as often in young adulthood., Conclusion: Young adult inpatients with reoccurring psychiatric inpatient treatments have increased rates of severe ACEs. Thus, special attention should be given to identifying ACEs, evaluating needs for psychosocial support and therapy, and meeting these needs after discharge., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Fellinger, Knasmüller, Kocsis-Bogar, Wippel, Fragner, Mairhofer, Hochgatterer and Aigner.)

Published
2022
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35. The burden of unsubstantiated messaging: collegiate athletes' chronic traumatic encephalopathy mechanism beliefs.

Author

Beidler E, Bogar K, Wallace J, McAllister-Deitrick J, Anderson M, and Schatz P

Subjects
Athletes, Cross-Sectional Studies, Female, Humans, Male, Universities, Athletic Injuries complications, Athletic Injuries epidemiology, Chronic Traumatic Encephalopathy epidemiology, Chronic Traumatic Encephalopathy etiology
Abstract

Objective: To investigate factors associated with collegiate athletes' beliefs regarding chronic traumatic encephalopathy (CTE) mechanism., Design: Cross-sectional study., Methods: A total of 838 collegiate athletes (61.9% men) from seven institutions completed a 10-minute survey that captured information relative to demographics, diagnosed concussion history, formal sport-related concussion education, additional sources of concussion information, and beliefs about multiple concussions and premature return-to-play following a head impact as mechanisms for CTE., Results: More than half of collegiate athletes believed that multiple concussions (58.2%) and premature return-to-play (59.1%) may cause CTE. Those who reported getting concussion information from sports news had higher odds of believing multiple concussions and premature return-to-play were CTE mechanisms compared to those who did not get information from sports news sources. Additionally, CTE mechanism beliefs were significantly greater in collegiate athletes who were male, had sustained a previous diagnosed concussion, or had acquired concussion information from the NCAA., Conclusions: Sports news' reporting of CTE storylines, which highlight former male athletes with complex brain injury histories, may influence collegiate athletes' beliefs about concussion. Therefore, it is recommended that concussion awareness initiatives incorporate information related specifically to CTE to empower collegiate athletes with evidence-based, patient-oriented information and knowledge regarding this condition.

Published
2021
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36. A comparison of the three year course between chronic depression and depression with multiple vs. few prior episodes.

Author

Humer E, Kocsis-Bogar K, Berger T, Schröder J, Späth C, Meyer B, Moritz S, Lutz W, Probst T, and Klein JP

Subjects
Adult, Chronic Disease, Female, Humans, Male, Middle Aged, Patient Health Questionnaire, Quality of Life psychology, Randomized Controlled Trials as Topic, Self Report, Time Factors, Depression psychology, Depressive Disorder, Major psychology
Abstract

This study tested the hypothesis that chronic depression (CD) is more similar to depression with multiple prior episodes (ME) than to depression with few prior episodes (FE). Data from participants (n = 1013) with mild to moderate depressive symptoms (Patient Health Questionnaire [PHQ-9] score 5 - 14) who took part in a randomized control trial of an internet intervention for depression (EVIDENT trial) were re-analyzed. The MINI-interview was conducted to diagnose CD (n = 376). If CD was not diagnosed, the self-reported number of depressive episodes was used to categorize participants as having episodic depression with up to five (FE, n = 422) or more than five (ME, n = 215) prior episodes. Over a three-year period, participants were assessed repeatedly regarding the course of depression (PHQ-9, QIDS), quality of life (SF-12) and therapeutic progress (FEP-2). At baseline, most scores were different between CD and FE but comparable between CD and ME. Time to remission did not differ between CD and ME but was longer in CD compared to FE. Results suggest that ME closely resembles CD and that CD differs from FE., Competing Interests: Declaration of Competing Interests JPK received payments for presentations and publications by the following companies: Beltz, Hogrefe, Elsevier. BM is employed as research director at GAIA AG, the company that developed, owns, and operates the internet intervention investigated in this trial. All the other authors report no relationships with commercial interests., (Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2020
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37. Indirect (implicit) and direct (explicit) self-esteem measures are virtually unrelated: A meta-analysis of the initial preference task.

Author

Pietschnig J, Gittler G, Stieger S, Forster M, Gadek N, Gartus A, Kocsis-Bogar K, Kubicek B, Lüftenegger M, Olsen J, Prem R, Ruiz N, Serfas BG, and Voracek M

Subjects
Humans, Psychological Tests, Self Concept
Abstract

Background: The initial preference task (IPT) is an implicit measure that has featured prominently in the literature and enjoys high popularity because it offers to provide an unobtrusive and objective assessment of self-esteem that is easy to administer. However, its use for self-esteem assessment may be limited because of weak associations with direct personality measures. Moreover, moderator effects of sample- and study-related variables need investigation to determine the value of IPT-based assessments of self-esteem., Methods: Conventional and grey-literature database searches, as well as screening of reference lists of obtained articles, yielded a total of 105 independent healthy adult samples (N = 17,777) originating from 60 studies. Summary effect estimates and subgroup analyses for potential effect moderators (e.g., administration order, algorithm, rating type) were calculated by means of meta-analytic random- and mixed-effects models. Moreover, we accounted for potential influences of publication year, publication status (published vs. not), and participant sex in a weighted stepwise hierarchical multiple meta-regression. We tested for dissemination bias through six methods., Results: There was no noteworthy correlation between IPT-based implicit and explicit self-esteem (r = .102), indicating conceptual independence of these two constructs. Effects were stronger when the B-algorithm was used for calculation of IPT-scores and the IPT was administered only once, whilst all other moderators did not show significant influences. Regression analyses revealed a somewhat stronger (albeit non-significant) effect for men. Moreover, there was no evidence for dissemination bias or a decline effect, although effects from published studies were numerically somewhat stronger than unpublished effects., Discussion: We show that there is no noteworthy association between IPT-based implicit and explicit self-esteem, which is broadly consistent with dual-process models of implicit and explicit evaluations on the one hand, but also casts doubt on the suitability of the IPT for the assessment of implicit self-esteem on the other hand., Competing Interests: The authors have declared that no competing interests exist.

Published
2018
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38. Design and synthesis of β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of β-amyloid peptides.

Author

Swahn BM, Kolmodin K, Karlström S, von Berg S, Söderman P, Holenz J, Berg S, Lindström J, Sundström M, Turek D, Kihlström J, Slivo C, Andersson L, Pyring D, Rotticci D, Ohberg L, Kers A, Bogar K, von Kieseritzky F, Bergh M, Olsson LL, Janson J, Eketjäll S, Georgievska B, Jeppsson F, and Fälting J

Subjects
Administration, Oral, Alkynes chemical synthesis, Alkynes pharmacokinetics, Alkynes pharmacology, Amides chemical synthesis, Amides pharmacokinetics, Amides pharmacology, Amyloid Precursor Protein Secretases chemistry, Amyloid beta-Peptides metabolism, Animals, Aspartic Acid Endopeptidases chemistry, Biological Availability, Brain drug effects, Brain metabolism, Cell Line, Crystallography, X-Ray, ERG1 Potassium Channel, Ether-A-Go-Go Potassium Channels antagonists & inhibitors, Female, Fluorescence Resonance Energy Transfer, Humans, Hydrogen Bonding, Indoles pharmacokinetics, Indoles pharmacology, Mice, Mice, Inbred C57BL, Models, Molecular, Molecular Structure, Peptide Fragments metabolism, Permeability, Pyrimidines pharmacokinetics, Pyrimidines pharmacology, Stereoisomerism, Structure-Activity Relationship, Amyloid Precursor Protein Secretases antagonists & inhibitors, Aspartic Acid Endopeptidases antagonists & inhibitors, Indoles chemical synthesis, Pyrimidines chemical synthesis
Abstract

The evaluation of a series of aminoisoindoles as β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and the discovery of a clinical candidate drug for Alzheimer's disease, (S)-32 (AZD3839), are described. The improvement in permeability properties by the introduction of fluorine adjacent to the amidine moiety, resulting in in vivo brain reduction of Aβ40, is discussed. Due to the basic nature of these compounds, they displayed affinity for the human ether-a-go-go related gene (hERG) ion channel. Different ways to reduce hERG inhibition and increase hERG margins for this series are described, culminating in (S)-16 and (R)-41 showing large in vitro margins with BACE1 cell IC(50) values of 8.6 and 0.16 nM, respectively, and hERG IC(50) values of 16 and 2.8 μM, respectively. Several compounds were advanced into pharmacodynamic studies and demonstrated significant reduction of β-amyloid peptides in mouse brain following oral dosing.

Published
2012
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39. New aminoimidazoles as β-secretase (BACE-1) inhibitors showing amyloid-β (Aβ) lowering in brain.

Author

Gravenfors Y, Viklund J, Blid J, Ginman T, Karlström S, Kihlström J, Kolmodin K, Lindström J, von Berg S, von Kieseritzky F, Bogar K, Slivo C, Swahn BM, Olsson LL, Johansson P, Eketjäll S, Fälting J, Jeppsson F, Strömberg K, Janson J, and Rahm F

Subjects
Amyloid Precursor Protein Secretases chemistry, Amyloid beta-Peptides blood, Amyloid beta-Peptides cerebrospinal fluid, Animals, Aspartic Acid Endopeptidases chemistry, Brain metabolism, Cell Line, Crystallography, X-Ray, Dogs, Female, Guinea Pigs, Humans, Imidazoles chemistry, Imidazoles pharmacology, Male, Mice, Mice, Inbred C57BL, Models, Molecular, Molecular Structure, Peptide Fragments blood, Peptide Fragments cerebrospinal fluid, Permeability, Stereoisomerism, Structure-Activity Relationship, Tissue Distribution, Amyloid Precursor Protein Secretases antagonists & inhibitors, Amyloid beta-Peptides metabolism, Aspartic Acid Endopeptidases antagonists & inhibitors, Brain drug effects, Imidazoles chemical synthesis, Peptide Fragments metabolism
Abstract

Amino-2H-imidazoles are described as a new class of BACE-1 inhibitors for the treatment of Alzheimer's disease. Synthetic methods, crystal structures, and structure-activity relationships for target activity, permeability, and hERG activity are reported and discussed. Compound (S)-1m was one of the most promising compounds in this report, with high potency in the cellular assay and a good overall profile. When guinea pigs were treated with compound (S)-1m, a concentration and time dependent decrease in Aβ40 and Aβ42 levels in plasma, brain, and CSF was observed. The maximum reduction of brain Aβ was 40-50%, 1.5 h after oral dosing (100 μmol/kg). The results presented highlight the potential of this new class of BACE-1 inhibitors with good target potency and with low effect on hERG, in combination with a fair CNS exposure in vivo.

Published
2012
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40. A numerical method for the solution of the bidomain equations in cardiac tissue.

Author

Keener JP and Bogar K

Abstract

A numerical scheme for efficient integration of the bidomain model of action potential propagation in cardiac tissue is presented. The scheme is a mixed implicit-explicit scheme with no stability time step restrictions and requires that only linear systems of equations be solved at each time step. The method is faster than a fully explicit scheme and there is no increase in algorithmic complexity to use this method instead of a fully explicit method. The speedup factor depends on the timestep size, which can be set solely on the basis of the demands for accuracy. (c) 1998 American Institute of Physics.

Published
1998
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