609 results on '"Bogani, P."'
Search Results
2. Quantum interference enhances the performance of single-molecule transistors
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Chen, Zhixin, Grace, Iain M., Woltering, Steffen L., Chen, Lina, Gee, Alex, Baugh, Jonathan, Briggs, G. Andrew D., Bogani, Lapo, Mol, Jan A., Lambert, Colin J., Anderson, Harry L., and Thomas, James O.
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- 2024
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3. Porphyrin-fused graphene nanoribbons
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Chen, Qiang, Lodi, Alessandro, Zhang, Heng, Gee, Alex, Wang, Hai I., Kong, Fanmiao, Clarke, Michael, Edmondson, Matthew, Hart, Jack, O’Shea, James N., Stawski, Wojciech, Baugh, Jonathan, Narita, Akimitsu, Saywell, Alex, Bonn, Mischa, Müllen, Klaus, Bogani, Lapo, and Anderson, Harry L.
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- 2024
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4. Tunable chiral anomalies and coherent transport on a honeycomb lattice
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Saroka, Vasil A., Kong, Fanmiao, Downing, Charles A., Payod, Renebeth B., Fischer, Felix R., Sun, Xiankai, and Bogani, Lapo
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Condensed Matter - Mesoscale and Nanoscale Physics ,Nonlinear Sciences - Chaotic Dynamics - Abstract
The search for energy efficient materials is urged not only by the needs of modern electronics but also by emerging applications in neuromorphic computing and artificial intelligence. Currently, there exist two mechanisms for achieving dissipationless transport: superconductivity and the quantum Hall effect. Here we reveal that dissipationless transport is theoretically achievable on a honeycomb lattice by rational design of chiral anomalies tunable without any magnetic fields. Breaking the usual assumption of commensurability and applying an external electric field lead to electronic modes exhibiting chiral anomalies capable of dissipationless transport in the material bulk, rather than on the edge. As the electric field increases, the system reaches a cubic-like dispersion material phase. While providing performance comparable to other known honeycomb lattice-based ballistic conductors such as an armchair nanotube, zigzag nanoribbon and hypothetical cumulenic carbyne, this scheme provides routes to a strongly correlated localization due to flat band dispersion and to exotic cubic dispersion material featuring a pitchfork bifurcation and a critical slowing down phenomena. These results open a new research avenue for the design of energy efficient information processing and higher-order dispersion materials., Comment: 119 pages, 18 figures, 1 table
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- 2023
5. Cystic pancreatic neoplasms: what we need to know and new perspectives
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Galluzzo, Antonio, Bogani, Silvia, Fedeli, Filippo, Danti, Ginevra, and Miele, Vittorio
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- 2024
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6. Emissive brightening in molecular graphene nanoribbons by twilight states
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Sturdza, Bernd K., Kong, Fanmiao, Yao, Xuelin, Niu, Wenhui, Ma, Ji, Feng, Xinliang, Riede, Moritz K., Bogani, Lapo, and Nicholas, Robin J.
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- 2024
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7. The role of L1CAM as predictor of poor prognosis in stage I endometrial cancer: a systematic review and meta-analysis
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Giannini, Andrea, D’Oria, Ottavia, Corrado, Giacomo, Bruno, Valentina, Sperduti, Isabella, Bogani, Giorgio, Laganà, Antonio Simone, Chiantera, Vito, Caserta, Donatella, and Vizza, Enrico
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- 2024
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8. Quantum Interference Enhances the Performance of Single-Molecule Transistors
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Chen, Zhixin, Grace, Iain M., Woltering, Steffen L., Chen, Lina, Gee, Alex, Baugh, Jonathan, Briggs, G. Andrew D., Bogani, Lapo, Mol, Jan A., Lambert, Colin J., Anderson, Harry L., and Thomas, James O.
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Physics - Chemical Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
An unresolved challenge facing electronics at a few-nm scale is that resistive channels start leaking due to quantum tunneling. This affects the performance of nanoscale transistors, with single-molecule devices displaying particularly low switching ratios and operating frequencies, combined with large subthreshold swings.1 The usual strategy to mitigate quantum effects has been to increase device complexity, but theory shows that if quantum effects are exploited correctly, they can simultaneously lower energy consumption and boost device performance.2-6 Here, we demonstrate experimentally how the performance of molecular transistors can be improved when the resistive channel contains two destructively-interfering waves. We use a zinc-porphyrin coupled to graphene electrodes in a three-terminal transistor device to demonstrate a >104 conductance-switching ratio, a subthreshold swing at the thermionic limit, a > 7 kHz operating frequency, and stability over >105 cycles. This performance is competitive with the best nanoelectronic transistors. We fully map the antiresonance interference features in conductance, reproduce the behaviour by density functional theory calculations, and trace back this high performance to the coupling between molecular orbitals and graphene edge states. These results demonstrate how the quantum nature of electron transmission at the nanoscale can enhance, rather than degrade, device performance, and highlight directions for future development of miniaturised electronics., Comment: 11 pages, 4 figures
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- 2023
9. Negative equity – the value of reporting negative results
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Owen Sansom, Debora Bogani, Linus Reichenbach, and Sara Wells
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Medicine ,Pathology ,RB1-214 - Published
- 2024
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10. Ergonomics in the operating room and surgical training: a survey on the Italian scenario
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Stefano Restaino, Marco D’Indinosante, Federica Perelli, Martina Arcieri, Vittorio Cherchi, Marco Petrillo, Anna Franca Cavaliere, Stefano Cianci, Giulia Pellecchia, Roberto Luca Meniconi, Alessandro Coppola, Vito Chiantera, Giovanni Scambia, Lorenza Driul, Giuseppe Vizzielli, SPIGC Working Group, Berton Federico, Conti Luigi, Formisano Giampaolo, Guaitoli Eleonora, Iossa Angelo, Maruccia Michele, Mazzari Andrea, Oragano Luigi, Pasculli Alessandro, Ratti Francesca, Serenari Matteo, Settembrini Alberto, Sirignano Pasqualino, Soriero Domenico, Vallicelli Carlo, Cianci (Sicilia) Stefano, Iaco (Puglia) Giulia De, Falcone (Campania) Francesca, Giaccari (Triveneto) Sara, Giovenzana (Lombardia) Marco, Pasqui (Toscana) Edoardo, Petrillo (Sardegna) Marco, Portigliotti (Piemonte) Luca, Sena (Calabria) Giuseppe, Sparavigna (Liguria) Marco, Bettini Giordana, Fanello Gianfranco, Mendogni Paolo, Monteleone Lorenzo, Pertile Nicoletta Pia Ardò Davide, Tomaiuolo Pasquina, Negrello Sara, Di Bartolomeo Mattia, Patini Romeo, Vito Marcuzzo Alberto, Campione Alberto, Comacchio Giovanni, Murana Giacomo, Antonio Martino, Manitto Mattia, Galzerano Giuseppe, Di Marco Carlo, Velluti Francesco, Berardi Gianmauro, Romboli Andrea, Weindelmejer Jacopo, Tamburrino Domenico, Calarco Alessandro, Losco Luigi, Nacchiero Eleonora, Elia Rossella, Torto Federico Lo, Vicenti Giovanni, Pappalardo Vincenzo, Pisani Dafne, Palmisano Graziano, Brascia Debora, Troisi Luigi, Renzi Federica, Melandro Fabio, Pecere Silvia, Gazia Carlo, Di Franco Gregorio, Romano Gaetano, Bolletta Alberto, Botteri Emanuele, Di Meo Giovanna, Ronsini Carlo, Chiappetta Sonia, Sgaramella Ilaria, Pennestri Francesco, Girardi Antonella, Mariniello Donatella, Marcasciano Marco, Telegrafo Michele, Fragomeni Simona, Paoli Francesca De, Bogani Giorgio, Gueli Alletti Salvatore, Pedone Anchora Luigi, Della Corte Luigi, Piovano Elisa, Borghese Martina, Taliento Cristina, Raimondo Diego, Raffone Antonio, Casarin Jvan, Perrone Emanuele, Stabile Guglielmo, and Capozzi Vito
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surgery ,ergonomic ,gyne and obstetrics ,operatory room ,survey ,Public aspects of medicine ,RA1-1270 - Abstract
IntroductionSurgical-related injuries are frequent, in fact the reported percentage of musculoskeletal disorders in surgeons is between 47% and 87%. These conditions are caused by long periods of standing, incorrect postures, repeated movements, little rest between operations, the lack of integrated operator rooms, the correct number and arrangement of monitors and the use of non-ergonomic instruments. This survey aims to assess the Italian overview both highlighting how prevalent surgical-related injury is in our surgeons and whether there is an operating room ergonomics education program in Italian surgical specialty schools.MethodsAn anonymous questionnaire was designed through SurveyMonkey© web application. This survey was composed of 3 different sections concerning the general characteristics of the participants, their surgical background and any training performed, and any injuries or ailments related to the surgical activity. The survey was carried out in the period 1th of December 2022 and the 6th of February 2023.ResultsAt the close of our survey, 300 responses were collected. Among the participants, the two most represented specialties were Gynecology and Obstetrics (42.3%) and General Surgery (39.7%) and surgeons were mainly employed in the Northern regions of Italy (54.8%). Analyzing the participants’ background, 61.7% of the respondents had laparoscopic training during their training and only 53.1% had a pelvic trainer during their residency. In accordance with 98.7% of the respondents, during surgery we have the feeling of being in an uncomfortable position that causes discomfort or muscle pain, and regarding the frequency of these discomforts, the majority of our study population experiences these problems monthly (46.2%), while in 29.6% it is experienced weekly, 12.1% annually and finally 12.1% daily. The surgical approach that is most correlated with these disorders is laparoscopy (62.7%) while the one that causes the least discomfort is robotic surgery (1.4%). These discomforts cause 43.9% of our population to take a break or do short exercises to reduce pain during surgery, and the body areas most affected are the back (61.6%), neck (40.6%) and shoulders (37.8%).ConclusionDespite this, our survey allows us to highlight some now-known gaps present in the surgical training program of our schools and the lack of protection toward our surgeons during their long career.
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- 2024
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11. Intraoperative Three-Dimensional Transvaginal Ultrasound for Hysteroscopic Metroplasty: a Controlled Study
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Muzii, Ludovico, Galati, Giulia, Mattei, Giulia, Romito, Alessia, Di Donato, Violante, Palaia, Innocenza, Bogani, Giorgio, and Angioli, Roberto
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- 2023
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12. The Efficacy of Dienogest in Reducing Disease and Pain Recurrence After Endometriosis Surgery: a Systematic Review and Meta-Analysis
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Muzii, Ludovico, Di Tucci, Chiara, Galati, Giulia, Carbone, Fabiana, Palaia, Innocenza, Bogani, Giorgio, Perniola, Giorgia, Tomao, Federica, Kontopantelis, Evangelos, and Di Donato, Violante
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- 2023
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13. Garbage in, toxic data out: a proposal for ethical artificial intelligence sustainability impact statements
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Bogani, Ronny, Theodorou, Andreas, Arnaboldi, Luca, and Wortham, Robert H.
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- 2023
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14. Emissive brightening in molecular graphene nanoribbons by twilight states
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Bernd K. Sturdza, Fanmiao Kong, Xuelin Yao, Wenhui Niu, Ji Ma, Xinliang Feng, Moritz K. Riede, Lapo Bogani, and Robin J. Nicholas
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Science - Abstract
Abstract Carbon nanomaterials are expected to be bright and efficient emitters, but structural disorder, intermolecular interactions and the intrinsic presence of dark states suppress their photoluminescence. Here, we study synthetically-made graphene nanoribbons with atomically precise edges and which are designed to suppress intermolecular interactions to demonstrate strong photoluminescence in both solutions and thin films. The resulting high spectral resolution reveals strong vibron-electron coupling from the radial-breathing-like mode of the ribbons. In addition, their cove-edge structure produces inter-valley mixing, which brightens conventionally-dark states to generate hitherto-unrecognised twilight states as predicted by theory. The coupling of these states to the nanoribbon phonon modes affects absorption and emission differently, suggesting a complex interaction with both Herzberg–Teller and Franck– Condon coupling present. Detailed understanding of the fundamental electronic processes governing the optical response will help the tailored chemical design of nanocarbon optical devices, via gap tuning and side-chain functionalisation.
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- 2024
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15. Editorial: Early cervical cancer: laparotomic vs minimally invasive surgery and fertility-sparing possible strategies
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Violante Di Donato, Giorgio Bogani, Antonio Simone Laganà, and Andrea Giannini
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cervical cancer ,minimally invasive surgery ,laparotomic surgery ,fertility-sparing ,gynecologic surgery ,Medicine (General) ,R5-920 - Published
- 2024
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16. Employing the Aviation Model to Reduce Errors in Robotic Gynecological Surgery: A Narrative Review
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Stefano Restaino, Federico Paparcura, Martina Arcieri, Giulia Pellecchia, Alice Poli, Valerio Gallotta, Salvatore Gueli Alletti, Stefano Cianci, Vito Andrea Capozzi, Giorgio Bogani, Alessandro Lucidi, Marko Klarić, Lorenza Driul, Vito Chiantera, Fabrizio Dal Moro, Giovanni Scambia, and Giuseppe Vizzielli
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robotic surgery ,training ,simulation ,checklist ,aviation ,Medicine - Abstract
The operating room is the environment where harm to the patient is most likely. Robotic surgery was listed as one of the top 10 health hazards as late as 2020. Taking inspiration from other fields of application, such as aeronautics, checklists have been increasingly implemented in medical practice over the years, becoming essential components of the operating theatre. In addition to checklists, simulation has taken on a fundamental importance in reducing errors. This paper aims to provide a narrative review to assess the importance of checklists and training in robotic surgery and how they improve the outcome. A comprehensive literature search from January 2000 to September 2023 was conducted. A total of 97 articles were included in the initial search. Eleven studies were deemed relevant and were considered eligible for full-text reading. Among these, ten studies focused on the analysis of training effectiveness. An article in our review assessed the benefits of introducing checklists in the operating room. Innovations created in aviation, such as checklists and simulation, have entered the medical field to prevent human error. Developing dedicated checklist and surgical teams, through theoretical and practical training, has become essential in modern medicine. Tools such as checklists, training, and simulation are among the best methods to reduce adverse medical events.
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- 2024
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17. Smart Automotive Technology Adherence to the Law: (De)Constructing Road Rules for Autonomous System Development, Verification and Safety
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McLachlan, Scott, Neil, Martin, Dube, Kudakwashe, Bogani, Ronny, Fenton, Norman, and Schaffer, Burkhard
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Computer Science - Artificial Intelligence - Abstract
Driving is an intuitive task that requires skills, constant alertness and vigilance for unexpected events. The driving task also requires long concentration spans focusing on the entire task for prolonged periods, and sophisticated negotiation skills with other road users, including wild animals. These requirements are particularly important when approaching intersections, overtaking, giving way, merging, turning and while adhering to the vast body of road rules. Modern motor vehicles now include an array of smart assistive and autonomous driving systems capable of subsuming some, most, or in limited cases, all of the driving task. The UK Department of Transport's response to the Safe Use of Automated Lane Keeping System consultation proposes that these systems are tested for compliance with relevant traffic rules. Building these smart automotive systems requires software developers with highly technical software engineering skills, and now a lawyer's in-depth knowledge of traffic legislation as well. These skills are required to ensure the systems are able to safely perform their tasks while being observant of the law. This paper presents an approach for deconstructing the complicated legalese of traffic law and representing its requirements and flow. The approach (de)constructs road rules in legal terminology and specifies them in structured English logic that is expressed as Boolean logic for automation and Lawmaps for visualisation. We demonstrate an example using these tools leading to the construction and validation of a Bayesian Network model. We strongly believe these tools to be approachable by programmers and the general public, and capable of use in developing Artificial Intelligence to underpin motor vehicle smart systems, and in validation to ensure these systems are considerate of the law when making decisions.
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- 2021
18. Routine perioperative blood tests predict survival of resectable lung cancer
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Morelli, Daniele, Cantarutti, Anna, Valsecchi, Camilla, Sabia, Federica, Rolli, Luigi, Leuzzi, Giovanni, Bogani, Giorgio, and Pastorino, Ugo
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- 2023
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19. Routine perioperative blood tests predict survival of resectable lung cancer
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Daniele Morelli, Anna Cantarutti, Camilla Valsecchi, Federica Sabia, Luigi Rolli, Giovanni Leuzzi, Giorgio Bogani, and Ugo Pastorino
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Medicine ,Science - Abstract
Abstract There is growing evidence that inflammatory, immunologic, and metabolic status is associated with cancer patients survival. Here, we built a simple algorithm to predict lung cancer outcome. Perioperative routine blood tests (RBT) of a cohort of patients with resectable primary lung cancer (LC) were analysed. Inflammatory, immunologic, and metabolic profiles were used to create a single algorithm (RBT index) predicting LC survival. A concurrent cohort of patients with resectable lung metastases (LM) was used to validate the RBT index. Charts of 2088 consecutive LC and 1129 LM patients undergoing lung resection were evaluated. Among RBT parameters, C-reactive protein (CRP), lymphocytes, neutrophils, hemoglobin, albumin and glycemia independently correlated with survival, and were used to build the RBT index. Patients with a high RBT index had a higher 5-year mortality than low RBT patients (adjusted HR 1.93, 95% CI 1.62–2.31). High RBT patients also showed a fourfold higher risk of 30-day postoperative mortality (2.3% vs. 0.5%, p 0.0019). The LM analysis validated the results of the LC cohort. We developed a simple and easily available multifunctional tool predicting short-term and long-term survival of curatively resected LC and LM. Prospective external validation of RBT index is warranted.
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- 2023
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20. Precision Imaging in Cervical Cancer: A Comprehensive Approach to Diagnosis and Pre-treatment Evaluation
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Ilaria Cuccu, Tullio Golia D’Augè, Noemi Tonti, Emanuele De Angelis, Roberta Arseni, Giorgio Bogani, Ottavia D’Oria, Angela Musella, Giorgia Perniola, Ludovico Muzii, Violante Di Donato, and Andrea Giannini
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cervical cancer ,staging ultrasound ,mri ,pet-ct ,radiomics ,gynecological oncology ,Gynecology and obstetrics ,RG1-991 - Abstract
Objectives: Until 2018, cervical cancer (CC) was clinically staged; however, it was frequently under-staged. For this reason, in 2018, the International Federation of Gynecology and Obstetrics (FIGO) incorporated the imaging assessment into the staging of this malignancy. The aim of this review is to discuss available data regarding the role of imaging in the diagnosis, pretreatment staging, and how an adequate radiological evaluation could assist in the treatment planning for CC. Mechanism: An extensive literature search was conducted to identify relevant studies across various databases, including articles addressing topics related to imaging used in CC. The selected articles underwent thorough examination and evaluation to identify studies that met the objectives of this review, taking into account the specified inclusion and exclusion criteria. Subsequently, relevant data were extracted and analyzed for each article. Findings in Brief: Transvaginal ultrasound (TVS) and transrectal ultrasound (TRUS) have been shown to be accurate diagnostic tools to assessing the local spread of CC disease. Currently, magnetic resonance imaging (MRI) appears to offer the highest sensitivity, specificity, and accuracy in detecting parametrial and stromal invasion, as well as tumor size. Computed tomography (CT) and contrast-enhanced (CE)-CT are considered the best imaging modalities for the detection of lymph node metastases. However, positron emission tomography (PET) has demonstrated notable precision and exhibited high negative predictive value in predicting the pelvic nodal status during the early-stage diagnosis of CC diagnosis. Radiomics represents a newly introduced field of translational research with the potential to predict several clinically and pathological relevant variables in cervical carcinoma patients. These variables include disease staging, histological type, lymph node status, probability of recurrence, and estimated survival. Conclusions: Imaging plays an indispensable role in diagnosis, tumor staging, and monitoring the evolution of pathology in response to therapies over time. It provides physicians with the indispensable tool for optimal regulation of therapeutic strategy.
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- 2024
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21. Exceptionally clean single-electron transistors from solutions of molecular graphene nanoribbons
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Niu, Wenhui, Sopp, Simen, Lodi, Alessandro, Gee, Alex, Kong, Fanmiao, Pei, Tian, Gehring, Pascal, Nägele, Jonathan, Lau, Chit Siong, Ma, Ji, Liu, Junzhi, Narita, Akimitsu, Mol, Jan, Burghard, Marko, Müllen, Klaus, Mai, Yiyong, Feng, Xinliang, and Bogani, Lapo
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- 2023
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22. Efficient heating of single-molecule junctions for thermoelectric studies at cryogenic temperatures
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Gehring, Pascal, van der Star, Martijn, Evangeli, Charalambos, Roy, Jennifer J. Le, Bogani, Lapo, Kolosov, Oleg V., and van der Zant, Herre S. J.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
The energy dependent thermoelectric response of a single molecule contains valuable information about its transmission function and its excited states. However, measuring it requires devices that can efficiently heat up one side of the molecule while being able to tune its electrochemical potential over a wide energy range. Furthermore, to increase junction stability devices need to operate at cryogenic temperatures. In this work we report on a new device architecture to study the thermoelectric properties and the conductance of single molecules simultaneously over a wide energy range. We employ a sample heater in direct contact with the metallic electrodes contacting the single molecule which allows us to apply temperature biases up to $\Delta T = 60$K with minimal heating of the molecular junction. This makes these devices compatible with base temperatures $T_\mathrm{bath} <2$K and enables studies in the linear ($\Delta T \ll T_\mathrm{molecule}$) and non-linear ($\Delta T \gg T_\mathrm{molecule}$) thermoelectric transport regimes.
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- 2019
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23. A clinician’s dilemma: what should be communicated to women with oncogenic genital HPV and their partners regarding the risk of oral viral transmission?
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Ermelinda Monti, Giussy Barbara, Giada Libutti, Veronica Boero, Fabio Parazzini, Andrea Ciavattini, Giorgio Bogani, Lorenzo Pignataro, Beatrice Magni, Camilla Erminia Maria Merli, and Paolo Vercellini
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Human papilloma virus ,Cervical cancer ,Oropharyngeal cancer ,Vaccination ,Primary prevention ,Counseling ,Gynecology and obstetrics ,RG1-991 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Head and neck cancer, the sixth most common cancer worldwide, account for about 1 out of 20 malignant tumors. In recent years a reduction in the incidence of cervical cancer, but a concomitant major increase in the incidence of HPV-mediated oropharyngeal cancer caused by orogenital HPV transmission has been observed. Consequently, in wealthy countries oropharyngeal squamous-cell carcinomas (OPSCC) is now the most frequent HPV-related cancer, having overtaken cervical cancer. Without effective medical interventions, this incidence trend could continue for decades. As no specific precursor lesion has been consistently identified in the oral cavity and oropharynx, HPV vaccination is the logical intervention to successfully counteract also the rising incidence of OPSCCs. However, HPV vaccine uptake remains suboptimal, particularly in males, the population at higher risk of OPSCC. Alternative primary prevention measures, such as modifications in sexual behaviors, could be implemented based on knowledge of individual genital HPV status. Until recently, this information was not available at a population level, but the current gradual shift from cytology (Pap test) to primary HPV testing for cervical cancer screening is revealing the presence of oncogenic viral genotypes in millions of women. In the past, health authorities and professional organizations have not consistently recommended modifications in sexual behaviors to be adopted when a persistent high-risk HPV cervicovaginal infection was identified. However, given the above changing epidemiologic scenario and the recent availability of an immense amount of novel information on genital HPV infection, it is unclear whether patient counseling should change. The right of future partners to be informed of the risk could also be considered. However, any modification of the provided counseling should be based also on the actual likelihood of a beneficial effect on the incidence of HPV-associated oropharyngeal cancers. The risk is on one side to induce unjustified anxiety and provide ineffective instructions, on the other side to miss the opportunity to limit the spread of oral HPV infections. Thus, major health authorities and international gynecologic scientific societies should issue or update specific recommendations, also with the aim of preventing inconsistent health care professionals’ behaviors.
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- 2022
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24. Exchange-induced spin polarization in a single magnetic molecule junction
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Tian Pei, James O. Thomas, Simen Sopp, Ming-Yee Tsang, Nicola Dotti, Jonathan Baugh, Nicholas F. Chilton, Salvador Cardona-Serra, Alejandro Gaita-Ariño, Harry L. Anderson, and Lapo Bogani
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Science - Abstract
The spin exchange, which is central to spintronics, has been restricted to devices with long-range magnetic ordering to date. Here, Pei et al. design a single-molecule-magnet and utilize its internal spin exchange to control the current through a single-molecule junction with high spin polarization (>95%).
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- 2022
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25. Primary intestinal-type adenocarcinoma of the vulva. A case report and review of the literature
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Francesco Sopracordevole, Giulia Azzalini, Nicolò Clemente, Anna Del Fabro, Giorgio Giorda, Mariasole Fichera, Marco Gigante, Giorgio Bogani, and Vincenzo Canzonieri
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Vulvar cancer ,Intestinal-type adenocarcinoma ,Primary vulvar adenocarcinoma ,Cloacogenic vulvar adenocarcinoma ,Goblet cell ,Signet-ring cell ,Gynecology and obstetrics ,RG1-991 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Primary non-squamous cell carcinomas of the vulva are rare entities including various tumor types. Among these, primary vulvar intestinal-type adenocarcinoma (vPITA) is extremely rare. Until 2021, less than twenty-five cases have been reported in the literature. Case presentation: We report a case of vPITA in a 63 years old woman with a histopathological diagnosis of signet-ring cell intestinal type adenocarcinoma at vulvar biopsy. Accurate clinical and pathological work-up excluded secondary metastatic localization, and vPITA was diagnosed. The patient was treated with radical vulvectomy and bilateral inguinofemoral dissection. Adjuvant chemo-radiotherapy was performed because of a positive lymph node. At 20 months follow-up the patient was alive and free of disease. Conclusion: The prognosis of this very rare disease is unclear and optimal treatment is not well established. About 40% of clinical early-stage diseases reported in literature had positive inguinal nodes, more than in vulvar squamous cell carcinomas. A proper histopathologic and clinical diagnosis is mandatory to exclude secondary disease and to recommend an adequate treatment.
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- 2023
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26. A clinician’s dilemma: what should be communicated to women with oncogenic genital HPV and their partners regarding the risk of oral viral transmission?
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Monti, Ermelinda, Barbara, Giussy, Libutti, Giada, Boero, Veronica, Parazzini, Fabio, Ciavattini, Andrea, Bogani, Giorgio, Pignataro, Lorenzo, Magni, Beatrice, Merli, Camilla Erminia Maria, and Vercellini, Paolo
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- 2022
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27. Exchange-induced spin polarization in a single magnetic molecule junction
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Pei, Tian, Thomas, James O., Sopp, Simen, Tsang, Ming-Yee, Dotti, Nicola, Baugh, Jonathan, Chilton, Nicholas F., Cardona-Serra, Salvador, Gaita-Ariño, Alejandro, Anderson, Harry L., and Bogani, Lapo
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- 2022
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28. Paper-based genetic assays with bioconjugated gold nanorods and an automated readout pipeline
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Borri, Claudia, Centi, Sonia, Chioccioli, Sofia, Bogani, Patrizia, Micheletti, Filippo, Gai, Marco, Grandi, Paolo, Laschi, Serena, Tona, Francesco, Barucci, Andrea, Zoppetti, Nicola, Pini, Roberto, and Ratto, Fulvio
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- 2022
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29. Paper-based genetic assays with bioconjugated gold nanorods and an automated readout pipeline
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Claudia Borri, Sonia Centi, Sofia Chioccioli, Patrizia Bogani, Filippo Micheletti, Marco Gai, Paolo Grandi, Serena Laschi, Francesco Tona, Andrea Barucci, Nicola Zoppetti, Roberto Pini, and Fulvio Ratto
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Medicine ,Science - Abstract
Abstract Paper-based biosensors featuring immunoconjugated gold nanoparticles have gained extraordinary momentum in recent times as the platform of choice in key cases of field applications, including the so-called rapid antigen tests for SARS-CoV-2. Here, we propose a revision of this format, one that may leverage on the most recent advances in materials science and data processing. In particular, we target an amplifiable DNA rather than a protein analyte, and we replace gold nanospheres with anisotropic nanorods, which are intrinsically brighter by a factor of ~ 10, and multiplexable. By comparison with a gold-standard method for dot-blot readout with digoxigenin, we show that gold nanorods entail much faster and easier processing, at the cost of a higher limit of detection (from below 1 to 10 ppm in the case of plasmid DNA containing a target transgene, in our current setup). In addition, we test a complete workflow to acquire and process photographs of dot-blot membranes with custom-made hardware and regression tools, as a strategy to gain more analytical sensitivity and potential for quantification. A leave-one-out approach for training and validation with as few as 36 sample instances already improves the limit of detection reached by the naked eye by a factor around 2. Taken together, we conjecture that the synergistic combination of new materials and innovative tools for data processing may bring the analytical sensitivity of paper-based biosensors to approach the level of lab-grade molecular tests.
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- 2022
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30. Strong coupling of microwave photons to antiferromagnetic fluctuations in an organic magnet
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Mergenthaler, M., Liu, J., Roy, J. J. Le, Ares, N., Thompson, A. L., Bogani, L., Luis, F., Blundell, S. J., Lancaster, T., Ardavan, A., Briggs, G. A. D., Leek, P. J., and Laird, E. A.
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Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
Coupling between a crystal of di(phenyl)-(2,4,6-trinitrophenyl)iminoazanium radicals and a superconducting microwave resonator is investigated in a circuit quantum electrodynamics (circuit QED) architecture. The crystal exhibits paramagnetic behavior above 4~K, with antiferromagnetic correlations appearing below this temperature, and we demonstrate strong coupling at base temperature. The magnetic resonance acquires a field angle dependence as the crystal is cooled down, indicating anisotropy of the exchange interactions. These results show that multispin modes in organic crystals are suitable for circuit QED, offering a platform for their coherent manipulation. They also utilize the circuit QED architecture as a way to probe spin correlations at low temperature.
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- 2017
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31. Predicting the Risk of nOdal disease with histological and Molecular features in Endometrial cancer: the prospective PROME trial.
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Bogani, Giorgio, Lalli, Luca, Casarin, Jvan, Ghezzi, Fabio, Chiappa, Valentina, Fanfani, Francesco, Scambia, Giovanni, and Raspagliesi, Francesco
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- 2024
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32. Charge and Spin Transfer Dynamics in a Weakly Coupled Porphyrin Dimer.
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Kopp, Sebastian M., Redman, Ashley J., Rončević, Igor, Schröder, Lisa, Bogani, Lapo, Anderson, Harry L., and Timmel, Christiane R.
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- 2024
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33. Using Radiomics and Machine Learning Applied to MRI to Predict Response to Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer
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Valentina Chiappa, Giorgio Bogani, Matteo Interlenghi, Giulia Vittori Antisari, Christian Salvatore, Lucia Zanchi, Manuela Ludovisi, Umberto Leone Roberti Maggiore, Giuseppina Calareso, Edward Haeusler, Francesco Raspagliesi, and Isabella Castiglioni
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cervical cancer ,MRI ,radiomics ,neoadjuvant chemotherapy ,gynecology oncology ,Medicine (General) ,R5-920 - Abstract
Neoadjuvant chemotherapy plus radical surgery could be a safe alternative to chemo-radiation in cervical cancer patients who are not willing to receive radiotherapy. The response to neoadjuvant chemotherapy is the main factor influencing the need for adjunctive treatments and survival. In the present paper we aim to develop a machine learning model based on cervix magnetic resonance imaging (MRI) images to stratify the single-subject risk of cervical cancer. We collected MRI images from 72 subjects. Among these subjects, 28 patients (38.9%) belonged to the “Not completely responding” class and 44 patients (61.1%) belonged to the ’Completely responding‘ class according to their response to treatment. This image set was used for the training and cross-validation of different machine learning models. A robust radiomic approach was applied, under the hypothesis that the radiomic features could be able to capture the disease heterogeneity among the two groups. Three models consisting of three ensembles of machine learning classifiers (random forests, support vector machines, and k-nearest neighbor classifiers) were developed for the binary classification task of interest (“Not completely responding” vs. “Completely responding”), based on supervised learning, using response to treatment as the reference standard. The best model showed an ROC-AUC (%) of 83 (majority vote), 82.3 (mean) [79.9–84.6], an accuracy (%) of 74, 74.1 [72.1–76.1], a sensitivity (%) of 71, 73.8 [68.7–78.9], and a specificity (%) of 75, 74.2 [71–77.5]. In conclusion, our preliminary data support the adoption of a radiomic-based approach to predict the response to neoadjuvant chemotherapy.
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- 2023
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34. Prevention, Screening, Treatment and Follow-Up of Gynecological Cancers: State of Art and Future Perspectives
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Tullio Golia D'Augè, Andrea Giannini, Giorgio Bogani, Camilla Di Dio, Antonio Simone Laganà, Violante Di Donato, Maria Giovanna Salerno, Donatella Caserta, Vito Chiantera, Enrico Vizza, Ludovico Muzii, and Ottavia D’Oria
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gynecologic oncology ,cancer prevention ,gynecological cancers ,hpv vaccination ,screening programs ,Gynecology and obstetrics ,RG1-991 - Abstract
Objective: This study aims to analyze the available data on prevention and early diagnosis in gynecological cancers. Mechanism: A comprehensive search was performed in the PubMed (MEDLINE), EMBASE, SCOPUS and Web of Science databases. Findings in Brief: To date the prevention programmes of all degrees exist exclusively for cervical cancer. Human Papilloma Virus (HPV) vaccination prevents from infection and development of precancerous lesions and contributes significantly to the deflection of the incidence of cervical cancer. Screening for HPV-related lesions is worldwide performed by cervical smear (Pap-test) and HPV test. Finally, tertiary prevention is aimed at the treatment of previously diagnosticated lesions with the aid of surgery, chemotherapy, radiotherapy and immunotherapy. Unfortunately, to date the prevention programmes of other gynecological tumors have not reached a good performance; indeed, the primum movens that leads to the development of such neoplasms has not been identified yet. Actually, no screening programs for the early diagnosis of endometrial cancer are available, however, it is recommended the adoption of a healthy lifestyle and a balanced diet. Diagnostic biomarkers would be helpful for screening asymptomatic high-risk women, but histopatological examinations remain the gold standard for diagnosis of endometrial cancer. Similarly, there are no screening tests for the diagnosis of ovarian cancer. In recent years many steps forward have been made in this field and new perspectives have been presented, however, additional investigation is needed to optimize the duration and timing of treatment, examine its cost-effectiveness, and identify potential tumor or host biologic factors predictive of the efficacy and adverse events. Finally, there are no primary and secondary prevention for vulvar cancer so patients should be invited to self-examination and pay attention to the presence of symptoms. Conclusions: Are the available screening programs for the diagnosis of gynecological carcinomas sufficient? The prevention and the diagnosis of precancerous lesions is the goal to be achieved for all gynecological cancers in order to improve patient outcomes, reduce the costs for managing the disease and prolonged follow up.
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- 2023
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35. The Adoption of Radiomics and machine learning improves the diagnostic processes of women with Ovarian MAsses (the AROMA pilot study)
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Chiappa, Valentina, Bogani, Giorgio, Interlenghi, Matteo, Salvatore, Christian, Bertolina, Francesca, Sarpietro, Giuseppe, Signorelli, Mauro, Castiglioni, Isabella, and Raspagliesi, Francesco
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- 2021
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36. Trend of HPV 16/18 Genotypes in Cervical Intraepithelial Neoplasia Grade 3: Data for 2007–2018
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Giannella L, Delli Carpini G, Di Giuseppe J, Bogani G, Gardella B, Monti E, Liverani CA, Ghelardi A, Insinga S, Montanari M, Raspagliesi F, Spinillo A, Vercellini P, Roncella E, and Ciavattini A
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cervical cancer ,cervical intraepithelial neoplasia ,cervical cancer screening program ,hpv vaccine ,hpv-16/18 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Luca Giannella,1 Giovanni Delli Carpini,1 Jacopo Di Giuseppe,1 Giorgio Bogani,2 Barbara Gardella,3 Ermelinda Monti,4 Carlo Antonio Liverani,4 Alessandro Ghelardi,5 Salvatore Insinga,1 Michele Montanari,1 Francesco Raspagliesi,2 Arsenio Spinillo,3 Paolo Vercellini,4 Elena Roncella,4 Andrea Ciavattini1 1Woman’s Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Ancona, Italy; 2Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy; 3Department of Obstetrics and Gynecology, Fondazione IRCCS Policlinico San Matteo, Università degli Studi di Pavia, Pavia, Italy; 4Gynaecology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; 5Azienda Usl Toscana Nord-Ovest, UOC Ostetricia e Ginecologia, Ospedale Apuane, Massa, ItalyCorrespondence: Andrea CiavattiniWoman’s Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, via Filippo Corridoni, 16, Ancona, 60123, ItalyTel +390715962172Fax +3907136576Email ciavattini.a@libero.itAim: In the post-vaccination era, the starting age and time intervals of cervical screening could change (older age and longer screening intervals). This scenario may be achieved by significantly reducing human papillomavirus (HPV) 16/18 prevalence (genotypes included in the current vaccines). In this regard, assessing the trend over time of these HPV infections in high-grade cervical lesions can provide information on the objective. The present study aimed to evaluate the trend of HPV 16/18 over the years 2007– 2018 in women with cervical intraepithelial neoplasia (CIN) grade 3.Methods: This is a retrospective multi-institutional study including HPV genotyped and unvaccinated women under 30 with CIN3. The sample was divided into the following periods: 2007– 2010, 2011– 2014, 2015– 2018. HPV genotypes were grouped in genotypes 16/18, genotypes 31/33/35/52/58/67 (genetically related to HPV16), genotypes 39/45/59/68/70 (genetically related to HPV18), genotypes 31/33/45/52/58 (high-risk types included in the nonavalent vaccine), possibly carcinogenic HPV (genotypes 26/30/53/67/70/73/82/85), low-risk HPV (genotypes 6/11/40/42/43/44/54/55/61). The trend between periods and HPV genotypes was measured using the Cochran–Armitage test for trend.Results: The final analysis included 474 participants. HPV 16/18 prevalence decreased significantly over the years (77.8% vs 68.9% vs 66.0%, respectively, Ptrend=0.027). Possibly carcinogenic HPV (genotypes 26/30/53/67/70/73/82/85) showed a significant negative prevalence trend over time (4.9% vs 1.1% vs 1.3%, respectively, Ptrend=0.046). Finally, there was a significant positive trend over the years for high-risk HPV genotypes 31/33/45/52/58 in women under 25 (9.9% vs 17.0% vs 24.0%, respectively, Ptrend=0.048).Conclusion: The prevalence of CIN3 lesions related to HPV 16/18 genotypes decreased over time from 2007 to 2018. These data highlight a herd effect of the HPV vaccine. However, fifteen years after HPV vaccine introduction, we are still a long way from herd immunity. The increase in high-risk types 31/33/45/52/58 will need to be reassessed when the nonavalent vaccine impact will be more reliable.Keywords: cervical cancer, cervical intraepithelial neoplasia, cervical cancer screening program, HPV vaccine, HPV-16/18
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- 2021
37. Therapeutic Approaches to Vulvar Cancer: A Review of Literature
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Tullio Golia D'Augè, Ilaria Firulli, Giorgia Di Bartolomeo, Ilaria Cuccu, Camilla Turetta, Angelo Trezza, Giorgio Bogani, Innocenza Palaia, Giorgia Perniola, Federica Tomao, Ludovico Muzii, Violante Di Donato, Ottavia D'Oria, and Andrea Giannini
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vulvar cancer ,vulvectomy ,nodal status ,vulvar flap ,vulvar surgery ,vulvar safe margins ,Gynecology and obstetrics ,RG1-991 - Abstract
Objective: Vulvar cancer is a rare gynecological cancer that mainly affects postmenopausal women. The aim of this review is to analyze the most recent data available in the literature on the clinical and therapeutic approach to vulvar carcinoma. Mechanism: Studies available in the literature on the therapeutic management of patients with vulvar carcinoma until November 2022 have been screened. A comprehensive search was performed in the PubMed (MEDLINE), EMBASE, SCOPUS and Web of Science databases. Findings in Brief: The approach to vulvar carcinoma has deeply evolved over the years. The management of early-stage vulvar carcinomas is well established and widely shared, while that of advanced and recurrent cancers is a subject of debate. The assessment of the nodal status has changed from the past with the passage from inguinal lymphadenectomy to the removal of only the sentinel node. Conclusions: The gold standard for the management of vulvar cancer is surgery, applicable in the first instance in early-stage tumors and after neoadjuvant therapy for larger tumors. Assessment of the nodal state is crucial and the method to be used depends on the degree of suspicious of positive lymph nodes. The prognosis is good if the treatment is applicable as soon as possible.
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- 2023
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38. A decision support system based on radiomics and machine learning to predict the risk of malignancy of ovarian masses from transvaginal ultrasonography and serum CA-125
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Valentina Chiappa, Matteo Interlenghi, Giorgio Bogani, Christian Salvatore, Francesca Bertolina, Giuseppe Sarpietro, Mauro Signorelli, Dominique Ronzulli, Isabella Castiglioni, and Francesco Raspagliesi
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Artificial intelligence ,Machine learning ,CA-125 antigen ,Ovarian neoplasms ,Ultrasonography ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background To evaluate the performance of a decision support system (DSS) based on radiomics and machine learning in predicting the risk of malignancy of ovarian masses (OMs) from transvaginal ultrasonography (TUS) and serum CA-125. Methods A total of 274 consecutive patients who underwent TUS (by different examiners and with different ultrasound machines) and surgery, with suspicious OMs and known CA-125 serum level were used to train and test a DSS. The DSS was used to predict the risk of malignancy of these masses (very low versus medium-high risk), based on the US appearance (solid, liquid, or mixed) and radiomic features (morphometry and regional texture features) within the masses, on the shadow presence (yes/no), and on the level of serum CA-125. Reproducibility of results among the examiners, and performance accuracy, sensitivity, specificity, and area under the curve were tested in a real-world clinical setting. Results The DSS showed a mean 88% accuracy, 99% sensitivity, and 77% specificity for the 239 patients used for training, cross-validation, and testing, and a mean 91% accuracy, 100% sensitivity, and 80% specificity for the 35 patients used for independent testing. Conclusions This DSS is a promising tool in women diagnosed with OMs at TUS, allowing to predict the individual risk of malignancy, supporting clinical decision making.
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- 2021
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39. A perspective on radicaloid conjugated polycyclic hydrocarbons
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Pozo, Iago and Bogani, Lapo
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The development of on-surface synthesis, together with the fusion of carbon materials and molecular magnetism, has sparked a revolution in the field of radicaloid conjugated polycyclic hydrocarbons. This advancement has enabled the preparation of reactive species and the study of their magnetic properties.Over the last few decades, relationships between magnetic coupling and chemical structure have been established. These findings have allowed the correlation of graphene sublattices with the magnetic nature of radicaloid nanographenes.Pulsed electron paramagnetic resonance (EPR) studies on radicaloid graphenoids have revealed their suitability for applications in quantum coherent technologies, showing relaxation times of around 1 ms, which is longer than several metallic quantum units.
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- 2024
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40. Electronically Reconfigurable Photonic Switches Incorporating Plasmonic Structures and Phase Change Materials
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Nikolaos Farmakidis, Nathan Youngblood, June Sang Lee, Johannes Feldmann, Alessandro Lodi, Xuan Li, Samarth Aggarwal, Wen Zhou, Lapo Bogani, Wolfram HP Pernice, C David Wright, and Harish Bhaskaran
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integrated opto‐electronics ,mixed‐mode PCM ,phase change photonics ,Science - Abstract
Abstract The ever‐increasing demands for data processing and storage will require seamless monolithic co‐integration of electronics and photonics. Phase‐change materials are uniquely suited to fulfill this function due to their dual electro‐optical sensitivity, nonvolatile retention properties, and fast switching dynamics. The extreme size disparity however between CMOS electronics and dielectric photonics inhibits the realization of efficient and compact electrically driven photonic switches, logic and routing elements. Here, the authors achieve an important milestone in harmonizing the two domains by demonstrating an electrically reconfigurable, ultra‐compact and nonvolatile memory that is optically accessible. The platform relies on localized heat, generated within a plasmonic structure; this uniquely allows for both optical and electrical readout signals to be interlocked with the material state of the PCM while still ensuring that the writing operation is electrically decoupled. Importantly, by miniaturization and effective thermal engineering, the authors achieve unprecedented energy efficiency, opening up a path towards low‐energy optoelectronic hardware for neuromorphic and in‐memory computing.
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- 2022
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41. Observing electron spin resonance between 0.1 and 67 GHz at temperatures between 50 mK and 300 K using broadband metallic coplanar waveguides
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Wiemann, Yvonne, Simmendinger, Julian, Clauss, Conrad, Bogani, Lapo, Bothner, Daniel, Koelle, Dieter, Kleiner, Reinhold, Dressel, Martin, and Scheffler, Marc
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We describe a fully broadband approach for electron spin resonance (ESR) experiments where it is possible to not only tune the magnetic field but also the frequency continuously over wide ranges. Here a metallic coplanar transmission line acts as compact and versatile microwave probe that can easily be implemented in different cryogenic setups. We perform ESR measurements at frequencies between 0.1 and 67 GHz and at temperatures between 50 mK and room temperature. Three different types of samples (Cr3+ ions in ruby, organic radicals of the nitronyl-nitroxide family, and the doped semiconductor Si:P) represent different possible fields of application for the technique. We demonstrate that an extremely large phase space in temperature, magnetic field, and frequency for ESR measurements, substantially exceeding the range of conventional ESR setups, is accessible with metallic coplanar lines., Comment: 6 pages, 5 figures
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- 2015
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42. Relaxometry and dephasing imaging of superparamagnetic magnetite nanoparticles using a single qubit
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Schmid-Lorch, Dominik, Häberle, Thomas, Reinhard, Friedemann, Zappe, Andrea, Slota, Michael, Bogani, Lapo, Finkler, Amit, and Wrachtrup, Jörg
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
To study the magnetic dynamics of superparamagnetic nanoparticles we use scanning probe relaxometry and dephasing of the nitrogen-vacancy (NV) center in diamond, characterizing the spin-noise of a single 10-nm magnetite particle. Additionally, we show the anisotropy of the NV sensitivity's dependence on the applied decoherence measurement method. By comparing the change in relaxation (T 1 ) and dephasing (T 2 ) time in the NV center when scanning a nanoparticle over it, we are able to extract the nanoparticle's diameter and distance from the NV center using an Ornstein-Uhlenbeck model for the nanoparticle's fluctuations. This scanning-probe technique can be used in the future to characterize different spin label substitutes for both medical applications and basic magnetic nanoparticle behavior.
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- 2015
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43. Outcomes of High-Grade Cervical Dysplasia with Positive Margins and HPV Persistence after Cervical Conization
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Andrea Giannini, Violante Di Donato, Francesco Sopracordevole, Andrea Ciavattini, Alessandro Ghelardi, Enrico Vizza, Ottavia D’Oria, Tommaso Simoncini, Francesco Plotti, Jvan Casarin, Tullio Golia D’Augè, Ilaria Cuccu, Maurizio Serati, Ciro Pinelli, Alice Bergamini, Barbara Gardella, Andrea Dell’Acqua, Ermelinda Monti, Paolo Vercellini, Giovanni D’Ippolito, Lorenzo Aguzzoli, Vincenzo Dario Mandato, Luca Giannella, Cono Scaffa, Antonino Ditto, Francesca Falcone, Chiara Borghi, Mario Malzoni, Alessandra Di Giovanni, Maria Giovanna Salerno, Viola Liberale, Biagio Contino, Cristina Donfrancesco, Michele Desiato, Anna Myriam Perrone, Pierandrea De Iaco, Simone Ferrero, Giuseppe Sarpietro, Maria G. Matarazzo, Antonio Cianci, Stefano Cianci, Sara Bosio, Simona Ruisi, Lavinia Mosca, Raffaele Tinelli, Rosa De Vincenzo, Gian Franco Zannoni, Gabriella Ferrandina, Marco Petrillo, Giampiero Capobianco, Annunziata Carlea, Fulvio Zullo, Barbara Muschiato, Stefano Palomba, Stefano Greggi, Arsenio Spinillo, Fabio Ghezzi, Nicola Colacurci, Roberto Angioli, Pierluigi Benedetti Panici, Ludovico Muzii, Giovanni Scambia, Francesco Raspagliesi, and Giorgio Bogani
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HPV ,conization ,positive margins ,HPV persistence ,Medicine - Abstract
The objective of this work is to assess the 5-year outcomes of patients undergoing conization for high-grade cervical lesions that simultaneously present as risk factors in the persistence of HPV infection and the positivity of surgical resection margins. This is a retrospective study evaluating patients undergoing conization for high-grade cervical lesions. All patients included had both positive surgical margins and experienced HPV persistence at 6 months. Associations were evaluated with Cox proportional hazard regression and summarized using hazard ratio (HR). The charts of 2966 patients undergoing conization were reviewed. Among the whole population, 163 (5.5%) patients met the inclusion criteria, being at high risk due to the presence of positive surgical margins and experiencing HPV persistence. Of 163 patients included, 17 (10.4%) patients developed a CIN2+ recurrence during the 5-year follow-up. Via univariate analyses, diagnosis of CIN3 instead of CIN2 (HR: 4.88 (95%CI: 1.10, 12.41); p = 0.035) and positive endocervical instead of ectocervical margins (HR: 6.44 (95%CI: 2.80, 9.65); p < 0.001) were associated with increased risk of persistence/recurrence. Via multivariate analyses, only positive endocervical instead of ectocervical margins (HR: 4.56 (95%CI: 1.23, 7.95); p = 0.021) were associated with worse outcomes. In this high-risk group, positive endocervical margins is the main risk factor predicting 5-year recurrence.
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- 2023
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44. Novel Insights into Molecular Mechanisms of Endometrial Diseases
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Tullio Golia D’Augè, Ilaria Cuccu, Giusi Santangelo, Ludovico Muzii, Andrea Giannini, Giorgio Bogani, and Violante Di Donato
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n/a ,Microbiology ,QR1-502 - Abstract
Endometrial diseases are the most common gynecological pathologies in Western Countries [...]
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- 2023
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45. Role of Genomic and Molecular Biology in the Modulation of the Treatment of Endometrial Cancer: Narrative Review and Perspectives
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Ilaria Cuccu, Ottavia D’Oria, Ludovica Sgamba, Emanuele De Angelis, Tullio Golia D’Augè, Camilla Turetta, Camilla Di Dio, Maria Scudo, Giorgio Bogani, Violante Di Donato, Innocenza Palaia, Giorgia Perniola, Federica Tomao, Ludovico Muzii, and Andrea Giannini
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endometrial cancer ,molecular ,genetics ,target therapy ,personalized treatment ,Medicine - Abstract
Endometrial cancer (EC) is one of the most common gynecological malignancies in Western countries. Traditionally, loco-reginal dissemination and histological characteristics are the main prognostic factors. Nowadays, molecular and genomic profiling showed exciting results in terms of prognostication. According to the data provided by The Cancer Genome Atlas and other studies, molecular and genomic profiling might be useful in identifying patients al low, intermediate, and high risk of recurrence. However, data regarding the therapeutic value are scant. Several prospective studies are ongoing to identify the most appropriate adjuvant strategy in EC patients, especially for those with positive nodes and low volume disease. The molecular classification has offered the possibility to improve the risk stratification and management of EC. The aim of this review is to focus on the evolution of molecular classification in EC and its impact on the research approach and on clinical management. Molecular and genomic profiling might be useful to tailor the most appropriate adjuvant strategies in apparent early-stage EC.
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- 2023
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46. Complete mapping of the thermoelectric properties of a single molecule
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Gehring, Pascal, Sowa, Jakub K., Hsu, Chunwei, de Bruijckere, Joeri, van der Star, Martijn, Le Roy, Jennifer J., Bogani, Lapo, Gauger, Erik M., and van der Zant, Herre S. J.
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- 2021
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47. The cypsela (achene) of Echinacea purpurea as a diffusion unit of a community of microorganisms
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Cardinale, Massimiliano, Viola, Marian, Miceli, Elisangela, Faddetta, Teresa, Puglia, Anna Maria, Maggini, Valentina, Tani, Corrado, Firenzuoli, Fabio, Schiff, Silvia, Bogani, Patrizia, Fani, Renato, and Papini, Alessio
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- 2021
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48. Patterns of failure after adjuvant “sandwich” chemo-radio-chemotherapy in locally advanced (stage III–IVA) endometrial cancer
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Raspagliesi, Francesco, Bogani, Giorgio, Pinelli, Ciro, Casarin, Jvan, Cerrotta, Anna Maria, Delle Curti, Clelia Teresa, Ditto, Antonino, Chiappa, Valentina, Bosio, Sara, Bertolina, Francesca, Sarpietro, Giuseppe, Dell’Acqua, Andrea, Di Donato, Violante, and Ghezzi, Fabio
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- 2021
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49. Endometriosis-associated ovarian cancer: a different clinical entity.
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Maggiore, Umberto Leone Roberti, Bogani, G., Paolini, Biagio, Martinelli, Fabio, Chiarello, Giulia, Bascio, Ludovica Spanò, Chiappa, Valentina, Ferrero, Simone, Ditto, Antonino, and Raspagliesi, Francesco
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- 2024
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50. Left External Iliac Vein Injury During Laparoscopic Pelvic Lymphadenectomy for Early-Stage Ovarian Cancer: Our Experience and Review of Literature
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Raffaele Tinelli, Miriam Dellino, Luigi Nappi, Felice Sorrentino, Maurizio Nicola D'Alterio, Stefano Angioni, Giorgio Bogani, Salvatore Pisconti, Stefano Uccella, and Erica Silvestris
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injury ,iliac vein ,laparoscopy ,lymphadenectomy ,repair ,ovarian cancer ,Surgery ,RD1-811 - Abstract
Laparoscopic surgical staging is the standard treatment of early-stage ovarian tumors with similar survival outcomes if compared with laparotomic procedures. In this article, we report a case regarding an incidental external iliac vein injury during a pelvic lymphadenectomy for fertility sparing treatment of early-stage ovarian cancer with a video showing the laparoscopic repair without any consequence or side effect. A 36 year-old obese woman with Body Mass Index 30 kg/m2 referred at our hospital with an histological diagnosis of high grade ovarian serous carcinoma after a left laparoscopic salpingo-oophorectomy performed in another hospital. After an hysteroscopy with endometrial biopsy, a laparoscopic surgical staging with a pelvic and aortic lymphadenectomy with lymph-node dissection until the left renal vein, omentectomy, and appendectomy were performed. A thermal injury to the left external iliac vein occurred using the bipolar forceps during lymphadenectomy and was repaired after an immediate clamping of the site using endoclinch and the suction irrigator probe. The laceration on the iliac vein was successfully repaired using 10 mm laparoscopic titanium clips; after a follow-up of 42 months no recurrence was detected. In conclusion, laparoscopy is a safe and effective therapeutic option for fertility sparing treatment patients with early stage ovarian carcinoma with a significantly low morbidity and postoperative hospitalization, but it should be reserved for oncologic surgeons trained in advanced laparoscopic procedures and repair of vascular injuries potentially associated with high mortality rate.
- Published
- 2022
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