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2. Identifying high-risk profile in primary antiphospholipid syndrome through cluster analysis: French multicentric cohort study

Author

Guedon, Alexis F, Ricard, Laure, Laurent, Charlotte, De Moreuil, Claire, Urbanski, Geoffrey, Deriaz, Sophie, Gerotziafas, Grigorios, Elalamy, Ismail, Audemard, Alexandra, Chasset, Francois, Alamowitch, Sonia, Sellam, Jérémie, Boffa, Jean Jacques, Cohen, Ariel, Wahl, Clémentine, Abisror, Noemie, Maillot, François, Fain, Olivier, and Mekinian, Arsène

Subjects
Clinical Research, Autoimmune Disease, Rare Diseases, Lupus, Hematology, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Male, Female, Humans, Antiphospholipid Syndrome, Cohort Studies, Antibodies, Antiphospholipid, Lupus Erythematosus, Systemic, Autoimmune Diseases, Thrombosis, Lupus Erythematosus, Systemic, Clinical Sciences
Abstract

IntroductionAntiphospholipid syndrome (APS) is an autoimmune disease characterised by thrombosis (arterial, venous or small vessel) or obstetrical events and persistent antiphospholipid antibodies (aPL), according to the Sydney classification criteria. Many studies have performed cluster analyses among patients with primary APS and associated autoimmune disease, but none has focused solely on primary APS. We aimed to perform a cluster analysis among patients with primary APS and asymptomatic aPL carriers without any autoimmune disease, to assess prognostic value.MethodsIn this multicentre French cohort study, we included all patients with persistent APS antibodies (Sydney criteria) measured between January 2012 and January 2019. We excluded all patients with systemic lupus erythematosus or other systemic autoimmune diseases. We performed hierarchical cluster analysis on the factor analysis of mixed data coordinates results with baseline patient characteristics to generate clusters.ResultsWe identified four clusters: cluster 1, comprising 'asymptomatic aPL carriers', with low risk of events during follow-up; cluster 2, the 'male thrombotic phenotype', with older patients and more venous thromboembolic events; cluster 3, the 'female obstetrical phenotype', with obstetrical and thrombotic events; and cluster 4, 'high-risk APS', which included younger patients with more frequent triple positivity, antinuclear antibodies, non-criteria manifestations and arterial events. Regarding survival analyses, asymptomatic aPL carriers relapsed less frequently than the others, but no other differences in terms of relapse rates or deaths were found between clusters.ConclusionsWe identified four clusters among patients with primary APS, one of which was 'high-risk APS'. Clustering-based treatment strategies should be explored in future prospective studies.

Published
2023

3. Complement Terminal Pathway Activation and Intrarenal Immune Response in C3 Glomerulopathy

Author

Meuleman, Marie-Sophie, Petitprez, Florent, Pickering, Matthew C., Le Quintrec, Moglie, Artero, Mikel Rezola, Duval, Anna, Rabant, Marion, Gilmore, Alyssa, Boyer, Olivia, Hogan, Julien, Servais, Aude, Provot, François, Gnemmi, Vivianne, Eloudzeri, Maeva, Grunenwald, Anne, Buob, David, Boffa, Jean-Jacques, Moktefi, Anissa, Audard, Vincent, Goujon, Jean-Michel, Bridoux, Frank, Thervet, Eric, Karras, Alexandre, Roumenina, Lubka T., Frémeaux Bacchi, Véronique, Duong Van Huyen, Jean-Paul, and Chauvet, Sophie

Published
2024
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4. Non-criteria manifestations in primary antiphospholipid syndrome: a French multicenter retrospective cohort study

Author

Guédon, Alexis F, Catano, Jennifer, Ricard, Laure, Laurent, Charlotte, de Moreuil, Claire, Urbanski, Geoffrey, Deriaz, Sophie, Gerotziafas, Grigorios, Elalamy, Ismail, Audemard, Alexandra, Chasset, Francois, Alamowitch, Sonia, Sellam, Jérémie, Maillot, François, Boffa, Jean Jacques, Cohen, Ariel, Abisror, Noémie, Fain, Olivier, and Mekinian, Arsène

Subjects
Autoimmune Disease, Clinical Research, Rare Diseases, Hematology, Pediatric, Antibodies, Antiphospholipid, Antiphospholipid Syndrome, Cohort Studies, Female, Humans, Middle Aged, Pregnancy, Prospective Studies, Retrospective Studies, Antiphospholipid antibodies, Antiphospholipid syndrome, Non-criteria antiphospholipid syndrome, Clinical Sciences, Immunology, Public Health and Health Services, Arthritis & Rheumatology
Abstract

BackgroundFrom this retrospective study, we aimed to (1) describe the prevalence and characteristics of non-criteria features in primary antiphospholipid syndrome (p-APS) and (2) determine their prognostic value.MethodsThis retrospective French multicenter cohort study included all patients diagnosed with p-APS (Sydney criteria) between January 2012 and January 2019. We used Kaplan-Meier and adjusted Cox proportional hazards models to compare the incidence of relapse in p-APS with and without non-criteria manifestations.ResultsOne hundred and seventy-nine patients with p-APS were included during the study time, with a median age of 52.50 years [39.0; 65.25] and mainly women (n = 112; 62.6%). Among them, forty-three patients (24.0%) presented at least one non-criteria manifestation during the follow-up: autoimmune cytopenias (n = 17; 39.5%), Libman Sachs endocarditis (n = 5; 11.6%), APS nephropathy (n = 4; 9.3%), livedo reticularis (n = 8; 18.6%), and neurological manifestations (n = 12; 27.9%). In comparison to p-APS without any non-criteria manifestations (n = 136), p-APS with non-criteria features had more arterial thrombosis (n = 24; 55.8% vs n = 48; 35.3%; p = 0.027) and more frequent pre-eclampsia (n = 6; 14.3% vs n = 4; 3.1%; p = 0.02). The prevalence of triple positivity was significantly increased in patients with non-criteria features (n = 20; 47.6% vs n = 25; 19.8%; p = 0.001). Patients with p-APS and non-criteria manifestations (n = 43) received significantly more additional therapies combined with vitamin K antagonists and/or antiaggregants. Catastrophic APS (CAPS) tended to be more frequent in p-APS with non-criteria features (n = 2; 5.1% vs none; p = 0.074). The p-APS with non-criteria manifestations had significantly increased rates of relapse (n = 20; 58.8% vs 33; 33.7%; p = 0.018) in bivariate analysis, but in survival analyses, the hazard ratio (HR) of relapse was not significantly different between the two groups (HR at 1.34 [0.67; 2.68]; p = 0.40).ConclusionsThe presence of non-criteria features is important to consider, as they are associated with particular clinical and laboratory profiles, increased risk of relapse, and need for additional therapies. Prospective studies are necessary to better stratify the prognosis and the management of p-APS.

Published
2022

6. Combination Treatment with Verinurad and Allopurinol in CKD: A Randomized Placebo and Active Controlled Trial

Author

Heerspink, Hiddo J.L., Stack, Austin G., Terkeltaub, Robert, Jongs, Niels, Inker, Lesley A., Bjursell, Magnus, Maklad, Noha, Perl, Shira, Eklund, Olof, Rikte, Tord, Sjöström, C. David, Perkovic, Vlado, Chmelickova, Hana, Lukac, Martin, Bucek, Petr, Drasnar, Tomas, Dussol, Bertrand, Guerrot, Dominique, Legrand, Eric, Boffa, Jean-Jacques, Halimi, Jean-Michel, Zaoui, Philippe, Letoha, Annamaria, Hajdu, Csaba, Pall, Denes, Peterfai, Eva, Csécsei, Gyöngyi, Bezzegh, Katalin, Deak, Laszlo, Konyves, Laszlo, Zsom, Marianna, Danos, Peter, Vangel, Sandor, Vasas, Szilard, Oroszlan, Tamas, Zilahi, Zsolt, Leiba, Adi, Grossman, Alon, Leibowitz, Avshalom, Itzhak, Baruch, Daoud, Deeb, Farber, Evgeny, Adawi, Faiad, Nakhoul, Farid M., Chernin, Gil, Kenis, Irina, Wainstein, Julio, Zeller, Lior, Elias, Mazen, Atar, Shaul, Frajewicki, Victor, Yagil, Yoram, Armaly, Zaher A., Esposito, Ciro, Viazzi, Francesca, Gambaro, Giovanni, Piatti, Piermarco, Bonadonna, Riccardo C., Arias Delgadillo, Cristhian Ronaldt, Flores, Fernando Jimenez, Aguilera Real, Manuel Enrique, Fajardo-Campos, Pedro, Violante Ortiz, Rafael Margarito, Luna Ceballos, Rosa Isela, Duran-Barragan, Sergio, Zytkiewicz-Jaruga, Danuta, Krzyzagorska, Ewa, Skokowska, Ewa, Klodawska, Katarzyna, Mordaka, Robert, Mazur, Stanislaw, Stasinska, Teresa, Sulowicz, Wladyslaw, Constantin, Ciprian, Negru, Doru, Paveliu, Fraga-Silvia, Negrisanu, Gabriela Doina, Szilagyi, Iosif, Busegeanu, Mihaela Magdalena G., Pena, Mihai Cosmin, Avram, Rodica Ioana, Ardelean, Silvia Luminita, Ilavska, Adriana, Dzupina, Andrej, Oroszova, Aniko, Kolesarova, Eva, Obetkova, Ida, Smatanova, Iveta, Babikova, Jana, Fulop, Peter, Haffner, Radovan, Rayner, Brian L., Kruger, Dawid Stephanus, Urbach, Dorothea Vera, Mitha, Essack, Vally Mahomed Latiff, Gulam Hoosain, Makan, Hemant, du Plessis, Hermanus, Jurgens, Jaco Cornelius, Reddy, Jeevren, Trokis, Julien S., McHarry, Kirsten, Distiller, Lawrence Allen, Mayet, Leila, Burgess, Lesley Jean, Van Zyl, Louis Johan, Joshi, Mukesh P., Sebastian, Peter John, Du Toit, Samantha Maria, Blignaut, Suzanne C., Serrano, Antonio Galan, Morales, Cristobal, Poch, Esteban, Mosquera, Eva Marquez, Castro, Fernando Cereto, Gonzalez Martinez, Francisco Javier, Perez- Contreras, Francisco Javier, Fernandez-Fresnedo, Gema, Garcia Mendez, Isabel Fuencisla, Perez, Jonay Pantoja, Martinez, Jordi Calabia, Gorriz Teruel, Jose Luis, Nieto Iglesias, Luis Javier, Munoz-Torres, Manuel, Munar Vila, Maria Antonia, Arenas Jimenez, Maria Dolores, Dominguez-Lopez, Marta E., Val, Miguel Hueso, Terrades, Natalia Ramos, Olmo, Rafael Santamaria, Malek Marin, Tamara Gelen, Arif, Ahmed A., Lee, Benjamin J., Mehta, Bhasker R., Baker, Bruce H., Jere, Charles S., Bains, David G., Stricklin, David G., Cheung, Deanna, Echeverri, Diego, Vera, Edgard, Heurich, Eva-Maria, Sterba, Gary A., Hernandez, German T., Paez, Henry E., Acosta, Idalia A., Ahmed, Intekhab, Sachmechi, Issac, Madu, Ivy-Joan E., Obhrai, Jagdeep Singh, Hammoud, Jamal A., Tumlin, James A., Cain, James, Moya-Hechevarria, Jaynier, Connaire, Jeffrey J., Haggiagi, Jehad, Odren, Jennifer A., Bellucci-Jackson, Jennifer M., Yan, Jieshi, Parker, John C., Tolins, Jonathan P., Gomez-Cortes, Jose D., Cardona, Jose F., Mandry, Jose M., Olivero, Juan Jorge, Hendon, Kendra S., Kaveh, Kianoosh, Kooienga, Laura A., Bermudez, Lidia R., Rich, Lisa M., Gold, Marina, Gonzalez, Marisela, Schaefer, Matthew E., Welch, Michelle, Moustafa, Moustafa A., Mussaji, Murtaza, Pergola, Pablo E., Phaosawasdi, Piangwarin, Silva, Ricardo A., Presas, Ricardo, Lynn, Robert I., Kronfli, Saeed J., Ventrapragada, Sailaja V., Niranjan, Sankar N., Husain, Sayed, Satko, Scott, Jabbour, Serge A., Rovner, Sergio F., Gouge, Steven F., Joshi, Sudhir S., Ramachandran Subramanian, Varagur Bala, Lane, Wendy, Calhoun, Wesley, and Durham, William

Published
2024
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7. Atypical Anti-Glomerular Basement Membrane Nephritis: A Case Series From the French Nephropathology Group

Author

Daniel, Laurent, Doucet, Laurent, François, Arnaud, Gnemmi, Viviane, Vuiblet, Vincent, Chauveau, Bertrand, Gibier, Jean-Baptiste, Olagne, Jérôme, Morel, Antoine, Aydin, Selda, McAdoo, Stephen P., Viallet, Nicolas, Perrochia, Hélène, Pambrun, Emilie, Royal, Virginie, Demoulin, Nathalie, Kemeny, Jean-Louis, Philipponnet, Carole, Hertig, Alexandre, Boffa, Jean-Jacques, Plaisier, Emmanuelle, Domenger, Camille, Brochériou, Isabelle, Deltombe, Clément, Duong Van Huyen, Jean-Paul, Buob, David, Roufosse, Candice, Hellmark, Thomas, Audard, Vincent, Mihout, Fabrice, Nasr, Samih H., Renaudin, Karine, Moktefi, Anissa, and Rabant, Marion

Published
2024
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8. The genetic landscape and clinical spectrum of nephronophthisis and related ciliopathies

Author

Attié-Bitach, Tania, Comier-Daire, Valerie, Rozet, Jean-Michel, Frishberg, Yaacov, Llanas, Brigitte, Broyer, Michel, Mohsin, Nabil, Macher, Marie-Alice, Philip, Nicole, Baudouin, Véronique, Brackman, Damian, Loirat, Chantal, Charbit, Marina, Dehennault, Maud, Guyot, Claude, Bataille, Pierre, Elting, Mariet, Deschenes, Georges, Gropman, Andrea, Guest, Geneviève, Gagnadoux, Marie-France, Nicoud, Philippe, Cochat, Pierre, Ranchin, Bruno, Bensman, Albert, Guerrot, Anne-Marie, Knebelmann, Bertrand, Bilge, Ilmay, Bruno, Danièle, Burtey, Stéphane, Rouvière, Caroline Rousset, Caudwell, Valérie, Morin, Denis, Dollfus, Hélène, Maisin, Anne, Hamel, Christian, Bieth, Eric, Gie, Sophie, Goodship, Judith, Roussey, Gwenaelle, La Selve, Hermine, Nivet, Hubert, Bessenay, Lucie, Caillez, Mathilde, Palcoux, Jean Bernard, Benoît, Stéphane, Dubot, Philippe, Fila, Marc, Giuliano, Fabienne, Iftene, Daouya, Kessler, Michele, Kwon, Theresa, Lahoche, Anine, Laurent, Audrey, Leclerc, Anne-Laure, Milford, David, Neuhaus, Thomas, Odent, Sylvie, Eckart, Philippe, Chauveau, Dominique, Niaudet, Patrick, Repetto, Horacio, Taque, Sophie, Bruel, Alexandra, Noel-Botte, Alexandra, Launay, Emma Allain, Allard, Lisa, Anlicheau, Dany, Adra, Anne-Laure, Garnier, Arnaud, Nagra, Arvind, Baatard, Remy, Bacchetta, Justine, Sadikoglu, Banu, Barnerias, Christine, Barthelemy, Anne, Basel, Lina, Bassilios, Nader, Ben Maiz, Hedi, Ben Moussa, Fatma, Benmati, Faïza, Berthaud, Romain, Bertholet, Aurélia, Blanchier, Dominique, Boffa, Jean Jacques, Bouchireb, Karim, Bouhabel, Ihab, Boukerroucha, Zakaria, Bourdat-Michel, Guylhène, Boute, Odile, Brochard, Karine, Caumes, Roseline, Elalaoui, Siham Chafai, Chamontin, Bernard, Chastang, Marie Caroline, Pietrement, Christine, Richer, Christine, Legendre, Christophe, Dahan, Karin, Dalla-Vale, Fabienne, Thibaudin, Damien, Dauvergne, Maxime, Davourie, Salandre, Debeukelaer, Martin, Delbet, Jean Daniel, Deltas, Constantinos, Graber, Denis, Devillars, Nadège, Diouf, Boucar, Fenzy, Martine Doco, André, Jean-Luc, Joly, Dominique, Fryer, Alan, Albano, Laetitia, Cassuto, Elisabeth, Pincon, Aline, Medeira, Ana, Chaussenot, Annabelle, Mensire-Marinier, Anne, Bouissou, Francois, Decramer, Stephane, Bottani, Armand, Hummel, Aurélie, Karras, Alexandre, Katz, Avi, Azema, Christine, Janbon, Bénédicte, Roussel, Bernard, Bonniol, Claude, Mariat, Christiophe, Champion, Gérard, Chantreuil, Deborah, Chassaing, Nicolas, Mousson, Christiane, Baudeau, Christine, Cuntz, Delphine Hafdar, Mignot, Cyril, Dehoux, Laurene, Lacombe, Didier, Hannedouche, Thierry, Mérieau, Elodie, Charlin, Emmanuelle, Gauthier, Eric, Plasse, Florent, Faguer, Stanislas, Lebas, Fanny, Demurger, Florence, Emma, Francesco, Cartault, François, Dumont, Geneviève, Godefroid, Nathalie, Guigonis, Vincent, Hillaire, Sophie, Groothoff, Jaap, Dudley, Jan, Jourde-Chiche, Noémie, El Karoui, Khalil, Krid, Saoussen, Coudert, Krier, Bencheick, Larbi, Yver, Laurent, Lavocat, Marie-Pierre, De Sagazan, Le Monies, Leroy, Valerie, Thibaudin, Lise, Ingulli, Liz, Gwanmesia, Lorraine, Burglen, Lydie, Saïd-Menthon, Marie-Hélène, Carrera, Marta, Nizon, Mathilde, Melander, Catherine, Foulard, Michel, Blayo, Monique, Prinseau, Jacques, Jay, Nadine, Brun, Nathalie, Camille, Nicolas, Nobili, François, Devuyst, Olivier, Ben Brahim, Ouafa, Parvex, Paloma, Sabourin, Laurence Perrin, Blanc, Philippe, Vanhille, Philippe, Galichon, Pierre, Pierrepont, Sophie, Planquois, Vincent, Poussard, Gwenaelle, Noble, Claire Pouteil, Allal, Radia, Bernard, Raphaelle, Mounet, Raynaud, Cahen, Rémi, Touraine, Renaud, Rigothier, Claire, Ryckewaert, Amélie, Sacquepee, Mathieu, El Chehadeh, Salima, Samaille, Charlotte, Haq, Shuman, Simckes, Ari, Lanoiselée, Stéphanie, Tellier, Stephanie, Subra, Jean-François, Cloarec, Sylvie, Tenenbam, Julie, Lamy, Thomas, Garraud, Valérie Drouin, Valette, Huguette, Meyssonnier, Vanina, Vargas-Poussou, Rosa, Snajer, Yves, Durault, Sandrine, Plaisier, Emmanuelle, Berard, Etienne, Fakhouri, Fadi, Louillet, Ferielle, Finielz, Paul, Fischbach, Michel, Foliguet, Bernard, Francois-Pradier, Hélène, Garaix, Florentine, Gerard, Marion, Rizzoni, Gianfranco, Gilbert, Brigitte, Glotz, Denis, Dubrasquet, Astrid Godron, Grünfeld, Jean-Pierre, Bollee, Guillaume, Hall, Michelle, Hansson, Sverker, Haye, Damien, Taffin, Hélène, Hildebrandt, Friedhelm, Hourmand, Maryvonne, Kayserili, Hümya, Tack, Ivan, Jacquemont, Marie Line, Fabre-Teste, Jennifer, Kashtan, Cliff, Van Hoeck, Kkoen, Klein, Alexandre, Knefati, Yannick, Knoers, Nine, Konrad, Martin, Lachaux, Alain, Landru, Isabelle, Landthaler, Gilbert, Lang, Philippe, Le Pogamp, Patrick, Legris, Tristan, Didailler, Catherine, Lobbedez, Thierry, de Parscau, Loïc, Pinson, Lucile, Maheut, Hervé, Duval-Arnould, Marc, Rio, Marlène, Gubler, Marie-Claire, Merville, Pierre, Mestrallet, Guillaume, Meunier, Maite, Moreau, Karine, Harambat, Jérôme, Morgan, Graeme, Mourad, Georges, Stuber, Niksic, Boespflug-Tanguy, Odile, Dunand, Olivier, Niel, Olivier, Ouali, Nacera, Malvezzi, Paolo, Jaoude, Pauline Abou, Pelletier, Solenne, Peltier, Julie, Petersen, M.B., Michel, Philippe, Rémy, Philippe, Philit, Jean-Baptiste, Pichault, Valérie, Billette de Villemeur, Thierry, Boudailliez, Bernard, Leheup, Bruno, Dossier, Claire, Djeddi, Djamal-Dine, Berland, Yves, Hurault de Ligny, Bruno, Rigden, Susan, Robino, Christophe, Rossi, Annick, Sarnacki, Sabine, Saidani, Messaoud, Sartorius, Albane Brodin, Schäfer, Elise, Laszlo, Sztriha, Thouret, Marie-Christine, Thuillier-Lecouf, Angélique, Trachtman, Howard, Trivin, Claire, Tsimaratos, Michel, Van Damme-Lombaerts, Rita, Willems, Marjolaine, Youssef, Michel, Zaloszyc, Ariane, Zawodnik, Alexis, Ziliotis, Marie-Julia, Petzold, Friederike, Billot, Katy, Chen, Xiaoyi, Henry, Charline, Filhol, Emilie, Martin, Yoann, Avramescu, Marina, Douillet, Maxime, Morinière, Vincent, Krug, Pauline, Jeanpierre, Cécile, Tory, Kalman, Boyer, Olivia, Burgun, Anita, Servais, Aude, Salomon, Remi, Benmerah, Alexandre, Heidet, Laurence, Garcelon, Nicolas, Antignac, Corinne, Zaidan, Mohamad, and Saunier, Sophie

Published
2023
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9. Combining robust urine biomarkers to assess chronic kidney disease progression

Author

Vrtovsnik, François, Daugas, Eric, Flamant, Martin, Vidal-Petiot, Emmanuelle, Jacquot, Christian, Karras, Alexandre, Roueff, Stéphane, Thervet, Eric, Houillier, Pascal, Courbebaisse, Marie, Eladari et Gérard Maruani, Dominique, Urena-Torres, Pablo, Boffa, Jean-Jacques, Ronco, Pierre, Fessi, H., Rondeau, Eric, Letavernier, Emmanuel, Tabibzadeh, Nahid, Haymann, Jean-Philippe, Bienaimé, Frank, Muorah, Mordi, Metzger, Marie, Broeuilh, Melanie, Houiller, Pascal, Vonderscher, Jacky, Mizrahi, Jacques, Friedlander, Gérard, Stengel, Bénédicte, and Terzi, Fabiola

Published
2023
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10. Exome-First Strategy in Adult Patients With CKD: A Cohort Study

Author

Doreille, Alice, Lombardi, Yannis, Dancer, Marine, Lamri, Radoslava, Testard, Quentin, Vanhoye, Xavier, Lebre, Anne-Sophie, Garcia, Hugo, Rafat, Cédric, Ouali, Nacera, Luque, Yosu, Izzedine, Hassan, Esteve, Emmanuel, Cez, Alexandre, Petit-Hoang, Camille, François, Hélène, Marchal, Armance, Letavernier, Emmanuel, Frémeaux-Bacchi, Véronique, Boffa, Jean-Jacques, Rondeau, Eric, Raymond, Laure, and Mesnard, Laurent

Published
2023
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12. Gestion pratique des inhibiteurs de PARP : Un consensus national DELPHI

Author

Selle, Frédéric, Boffa, Jean-Jacques, Etienne, Gabriel, Angelergues, Antoine, Augereau, Paule, Berton, Dominique, Dielenseger, Pascale, Fabbro, Michel, Falandry, Claire, Follana, Philippe, Gladieff, Laurence, Joly, Florence, Kurtz, Jean-Emmanuel, Matta, Carla, Mouret-Reynier, Marie-Ange, Schmitt, Antonin, Scotté, Florian, Marjollet, Coralie, and Floquet, Anne

Published
2022
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14. Clinical and prognostic significance of antinuclear antibodies in primary antiphospholipid syndrome: A multicenter retrospective study

Author

Ricard, Laure, Laurent, Charlotte, Papo, Matthias, Deriaz, Sophie, Catano, Jennifer, Alamowitch, Sonia, Kayem, Gilles, Chasset, François, De Moreuil, Claire, Boffa, Jean Jacques, Gerotziafas, Grigorios, Elalamy, Ismail, Bornes, Marie, Maillot, François, Audemard-Verger, Alexandra, Planche, Virginie, Ballot, Eric, Fain, Olivier, and Mekinian, Arsène

Published
2022
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15. Kidney involvement in myelodysplastic syndromes.

Author

Lafargue, Marie-Camille, Huyen, Jean-Paul Duong Van, Rennke, Helmut G, Essig, Marie, Bobot, Mickaël, Jourde-Chiche, Noémie, Sakhi, Hamza, KARRAS, Alexandre, Boudhabhay, Idris, Brunet, Philippe, Boulay, Hugoline, Grobost, Vincent, Philipponnet, Carole, Jeannel, Juliette, Chemouny, Jonathan, Boffa, Jean-Jacques, Braham-Stambouli, Dorra, Selamet, Umut, Riella, Leonardo V, and Fain, Olivier

Subjects
ANTINEUTROPHIL cytoplasmic antibodies, ACUTE kidney failure, ACUTE myeloid leukemia, MYELODYSPLASTIC syndromes, CHRONIC kidney failure, POLYARTERITIS nodosa, IGA glomerulonephritis
Abstract

Introduction The objective of this study was to describe kidney involvement in patients with myelodysplastic syndromes (MDS), their treatments, and outcomes. Methods We conducted a multicenter retrospective study in seven centers, identifying MDS patients with acute kidney injury (AKI), chronic kidney disease (CKD), and urine abnormalities. Results Fifteen patients developed a kidney disease 3 months after MDS diagnosis. Median urine protein-to-creatinine ratio was 1.9 g/g, and median serum creatinine was 3.2 mg/dL. Ten patients had AKI at presentation, and 12 had extra-renal symptoms. The renal diagnoses included anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), ANCA negative vasculitis, C3 glomerulonephritis, immune complex-mediated glomerulonephritis, polyarteritis nodosa, and IgA vasculitis. All patients but one received a specific treatment for the MDS-associated kidney injury. The effect of MDS treatment on kidney injury could be assessed in six patients treated with azacitidine, and renal function evolution was heterogenous. After a median follow-up of 14 months, four patients had CKD stage 3, five had CKD stage 4, and three had end stage kidney disease. On the other hand, three evolved to an acute myeloid leukemia and three died. Compared to 84 MDS controls, patients who had kidney involvement were younger, had a higher number of dysplasia lineages, and were more eligible to receive hypomethylating agents, but no survival difference was seen between the two groups. Compared to 265 AAV without MDS, the ten with MDS-associated pauci-immune vasculitis were older, ANCA serology was more frequently negative, and more cutaneous lesions were seen. Conclusion The spectrum of kidney injuries associated with MDS is mostly represented by vasculitis with glomerular involvement, and especially AAV. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Kidney biopsy for the diagnosis and treatment of kidney diseases* - Recommendations from the French speaking Society of Nephrology (SFNDT) and French National Authority for Health (HAS) 2022

Author

de Laforcade, Louis, primary, Bobots, Mickaël, additional, Boffa, Jean-Jacques, additional, Bovy, Christophe, additional, Cartery, Claire, additional, Chauveau, Dominique, additional, Gueutin, Victor, additional, Isnard-Bagnis, Corinne, additional, Jourde Chiche, Noémie, additional, Karras, Alexandre, additional, Meftah, Aimèle, additional, Müller, Clotilde, additional, Sié, Pierre, additional, Stehlé, Thomas, additional, Vrigneaud, Laurence, additional, Vuiblet, Vincent, additional, and Guerrot, Dominique, additional

Published
2024
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17. Longitudinal Bone Loss Occurs at the Radius in CKD

Author

Letavernier, Emmanuel, Ronco, Pierre, Fessi, Hafedh, Daugas, Eric, du Halgouet, Caroline, de La Faille, Renaud, d’Auzac, Christian, Maruani, Gerard, Vallet, Marion, Gauci, Cédric, Haymann, Jean Philippe, Thervet, Eric, Boffa, Jean-Jacques, Vrtovsnik, François, Froissart, Marc, Stengel, Bénédicte, Nicolet-Barousse, Laurence, Roland, Mélanie, Jacquot, Christian, Cailleaux, Pierre-Emmanuel, Ostertag, Agnes, Metzger, Marie, Boucquemont, Julie, Houillier, Pascal, Flamant, Martin, Ureña-Torres, Pablo, and Cohen-Solal, Martine

Published
2021
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18. Practical management of worsening renal function in outpatients with heart failure and reduced ejection fraction: Statement from a panel of multidisciplinary experts and the Heart Failure Working Group of the French Society of Cardiology

Author

Mewton, Nathan, Girerd, Nicolas, Boffa, Jean-Jacques, Courivaud, Cécile, Isnard, Richard, Juillard, Laurent, Lamblin, Nicolas, Legrand, Matthieu, Logeart, Damien, Mariat, Christophe, Meune, Edith, Sabouret, Pierre, Sebbag, Laurent, and Rossignol, Patrick

Published
2020
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20. Atypical Anti-Glomerular Basement Membrane Nephritis: A Case Series From the French Nephropathology Group

Author

Chauveau, Bertrand, primary, Gibier, Jean-Baptiste, additional, Olagne, Jérôme, additional, Morel, Antoine, additional, Aydin, Selda, additional, McAdoo, Stephen P., additional, Viallet, Nicolas, additional, Perrochia, Hélène, additional, Pambrun, Emilie, additional, Royal, Virginie, additional, Demoulin, Nathalie, additional, Kemeny, Jean-Louis, additional, Philipponnet, Carole, additional, Hertig, Alexandre, additional, Boffa, Jean-Jacques, additional, Plaisier, Emmanuelle, additional, Domenger, Camille, additional, Brochériou, Isabelle, additional, Deltombe, Clément, additional, Duong Van Huyen, Jean-Paul, additional, Buob, David, additional, Roufosse, Candice, additional, Hellmark, Thomas, additional, Audard, Vincent, additional, Mihout, Fabrice, additional, Nasr, Samih H., additional, Renaudin, Karine, additional, Moktefi, Anissa, additional, Rabant, Marion, additional, Daniel, Laurent, additional, Doucet, Laurent, additional, François, Arnaud, additional, Gnemmi, Viviane, additional, and Vuiblet, Vincent, additional

Published
2024
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21. Symptomatic SARS-CoV2 infection associated with high mortality in AA amyloidosis

Author

Bourguiba, Rim, primary, Terré, Alexandre, additional, Savey, Lea, additional, Oziol, Eric, additional, Hanslik, Thomas, additional, Kahn, Jean-Emmanuel, additional, Borie, Raphael, additional, Cez, Alexandre, additional, Buob, David, additional, Grateau, Gilles, additional, Boffa, Jean-Jacques, additional, and Georgin-Lavialle, Sophie, additional

Published
2023
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22. Low non‐relapse mortality and good haematological and renal responses after autologous haematopoietic stem cell transplantation in multiple myeloma patients with renal insufficiency at transplant: A prospective Société Francophone de Greffe de Moelle‐Thérapie Cellulaire observational study

Author

Garderet, Laurent, primary, Ouldjeriouat, Hafida, additional, Bekadja, Mohamed‐Amine, additional, Daguenet, Elisabeth, additional, Bigot, Noemie, additional, Vincent, Laure, additional, Roos‐Weil, Damien, additional, Vignon, Marguerite, additional, Ikhlef, Souhila, additional, Abraham, Julie, additional, Escoffre‐Barbe, Martine, additional, Lioure, Bruno, additional, Nacer, Redhouane Ahmed, additional, Lafon, Ingrid, additional, Mariette, Clara, additional, Karlin, Lionel, additional, Morel, Pierre, additional, Gilis, Lila, additional, Le Ray, Emanuelle, additional, Blouet, Anaïse, additional, Nguyen Quoc, Stéphanie, additional, Boffa, Jean Jacques, additional, Ronco, Pierre, additional, Lambert, Jerome, additional, and Cornillon, Jérôme, additional

Published
2023
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23. The Case | A paraneoplastic kidney injury?

Author

Duvaltier, Lucile, primary, El Karoui, Khalil, additional, Bosselut, Nelly, additional, Boutan-Laroze, Arnaud, additional, Boffa, Jean-Jacques, additional, Buob, David, additional, and Brousse, Romain, additional

Published
2023
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24. Symptomatic SARS-CoV2 infection associated with high mortality in AA amyloidosis.

Author

Bourguiba, Rim, Terré, Alexandre, Savey, Lea, Oziol, Eric, Hanslik, Thomas, Kahn, Jean-Emmanuel, Borie, Raphael, Cez, Alexandre, Buob, David, Grateau, Gilles, Boffa, Jean-Jacques, and Georgin-Lavialle, Sophie

Subjects
CARDIAC amyloidosis, SARS-CoV-2, AMYLOIDOSIS
Abstract

This document is a letter to the editor titled "Symptomatic SARS-CoV2 infection associated with high mortality in AA amyloidosis." The authors conducted a retrospective study on COVID-19 in patients with AA amyloidosis, a rare type of amyloidosis that occurs in patients with chronic systemic inflammation. They found that patients with AA amyloidosis are likely to be prone to severe COVID-19 due to chronic inflammation and associated comorbidities, especially kidney transplantation. The study revealed that 63% of patients developed a moderate to severe form of COVID-19, and renal transplant patients presented with severe or fatal disease. The effectiveness of vaccination against SARS-CoV2 in patients with AA amyloidosis on immunosuppressive therapy or high-dose steroids was inconclusive. Further studies are needed to evaluate the response to the SARS-CoV2 vaccine in patients with AA amyloidosis. [Extracted from the article]

Published
2024
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25. Combining robust urine biomarkers to assess chronic kidney disease progression

Author

Bienaimé, Frank, primary, Muorah, Mordi, additional, Metzger, Marie, additional, Broeuilh, Melanie, additional, Houiller, Pascal, additional, Flamant, Martin, additional, Haymann, Jean-Philippe, additional, Vonderscher, Jacky, additional, Mizrahi, Jacques, additional, Friedlander, Gérard, additional, Stengel, Bénédicte, additional, Terzi, Fabiola, additional, Vrtovsnik, François, additional, Daugas, Eric, additional, Vidal-Petiot, Emmanuelle, additional, Jacquot, Christian, additional, Karras, Alexandre, additional, Roueff, Stéphane, additional, Thervet, Eric, additional, Houillier, Pascal, additional, Courbebaisse, Marie, additional, Eladari et Gérard Maruani, Dominique, additional, Urena-Torres, Pablo, additional, Boffa, Jean-Jacques, additional, Ronco, Pierre, additional, Fessi, H., additional, Rondeau, Eric, additional, Letavernier, Emmanuel, additional, and Tabibzadeh, Nahid, additional

Published
2023
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26. The genetic landscape and clinical spectrum of nephronophthisis and related ciliopathies.

Author

Petzold, Friederike, primary, Billot, Katy, additional, Chen, Xiaoyi, additional, Henry, Charline, additional, Filhol, Emilie, additional, Martin, Yoann, additional, Avramescu, Marina, additional, Douillet, Maxime, additional, Morinière, Vincent, additional, Krug, Pauline, additional, Jeanpierre, Cécile, additional, Tory, Kalman, additional, Boyer, Olivia, additional, Burgun, Anita, additional, Servais, Aude, additional, Salomon, Remi, additional, Benmerah, Alexandre, additional, Heidet, Laurence, additional, Garcelon, Nicolas, additional, Antignac, Corinne, additional, Zaidan, Mohamad, additional, Saunier, Sophie, additional, Attié-Bitach, Tania, additional, Comier-Daire, Valerie, additional, Rozet, Jean-Michel, additional, Frishberg, Yaacov, additional, Llanas, Brigitte, additional, Broyer, Michel, additional, Mohsin, Nabil, additional, Macher, Marie-Alice, additional, Philip, Nicole, additional, Baudouin, Véronique, additional, Brackman, Damian, additional, Loirat, Chantal, additional, Charbit, Marina, additional, Dehennault, Maud, additional, Guyot, Claude, additional, Bataille, Pierre, additional, Elting, Mariet, additional, Deschenes, Georges, additional, Gropman, Andrea, additional, Guest, Geneviève, additional, Gagnadoux, Marie-France, additional, Nicoud, Philippe, additional, Cochat, Pierre, additional, Ranchin, Bruno, additional, Bensman, Albert, additional, Guerrot, Anne-Marie, additional, Knebelmann, Bertrand, additional, Bilge, Ilmay, additional, Bruno, Danièle, additional, Burtey, Stéphane, additional, Rouvière, Caroline Rousset, additional, Caudwell, Valérie, additional, Morin, Denis, additional, Dollfus, Hélène, additional, Maisin, Anne, additional, Hamel, Christian, additional, Bieth, Eric, additional, Gie, Sophie, additional, Goodship, Judith, additional, Roussey, Gwenaelle, additional, La Selve, Hermine, additional, Nivet, Hubert, additional, Bessenay, Lucie, additional, Caillez, Mathilde, additional, Palcoux, Jean Bernard, additional, Benoît, Stéphane, additional, Dubot, Philippe, additional, Fila, Marc, additional, Giuliano, Fabienne, additional, Iftene, Daouya, additional, Kessler, Michele, additional, Kwon, Theresa, additional, Lahoche, Anine, additional, Laurent, Audrey, additional, Leclerc, Anne-Laure, additional, Milford, David, additional, Neuhaus, Thomas, additional, Odent, Sylvie, additional, Eckart, Philippe, additional, Chauveau, Dominique, additional, Niaudet, Patrick, additional, Repetto, Horacio, additional, Taque, Sophie, additional, Bruel, Alexandra, additional, Noel-Botte, Alexandra, additional, Launay, Emma Allain, additional, Allard, Lisa, additional, Anlicheau, Dany, additional, Adra, Anne-Laure, additional, Garnier, Arnaud, additional, Nagra, Arvind, additional, Baatard, Remy, additional, Bacchetta, Justine, additional, Sadikoglu, Banu, additional, Barnerias, Christine, additional, Barthelemy, Anne, additional, Basel, Lina, additional, Bassilios, Nader, additional, Ben Maiz, Hedi, additional, Ben Moussa, Fatma, additional, Benmati, Faïza, additional, Berthaud, Romain, additional, Bertholet, Aurélia, additional, Blanchier, Dominique, additional, Boffa, Jean Jacques, additional, Bouchireb, Karim, additional, Bouhabel, Ihab, additional, Boukerroucha, Zakaria, additional, Bourdat-Michel, Guylhène, additional, Boute, Odile, additional, Brochard, Karine, additional, Caumes, Roseline, additional, Elalaoui, Siham Chafai, additional, Chamontin, Bernard, additional, Chastang, Marie Caroline, additional, Pietrement, Christine, additional, Richer, Christine, additional, Legendre, Christophe, additional, Dahan, Karin, additional, Dalla-Vale, Fabienne, additional, Thibaudin, Damien, additional, Dauvergne, Maxime, additional, Davourie, Salandre, additional, Debeukelaer, Martin, additional, Delbet, Jean Daniel, additional, Deltas, Constantinos, additional, Graber, Denis, additional, Devillars, Nadège, additional, Diouf, Boucar, additional, Fenzy, Martine Doco, additional, André, Jean-Luc, additional, Joly, Dominique, additional, Fryer, Alan, additional, Albano, Laetitia, additional, Cassuto, Elisabeth, additional, Pincon, Aline, additional, Medeira, Ana, additional, Chaussenot, Annabelle, additional, Mensire-Marinier, Anne, additional, Bouissou, Francois, additional, Decramer, Stephane, additional, Bottani, Armand, additional, Hummel, Aurélie, additional, Karras, Alexandre, additional, Katz, Avi, additional, Azema, Christine, additional, Janbon, Bénédicte, additional, Roussel, Bernard, additional, Bonniol, Claude, additional, Mariat, Christiophe, additional, Champion, Gérard, additional, Chantreuil, Deborah, additional, Chassaing, Nicolas, additional, Mousson, Christiane, additional, Baudeau, Christine, additional, Cuntz, Delphine Hafdar, additional, Mignot, Cyril, additional, Dehoux, Laurene, additional, Lacombe, Didier, additional, Hannedouche, Thierry, additional, Mérieau, Elodie, additional, Charlin, Emmanuelle, additional, Gauthier, Eric, additional, Plasse, Florent, additional, Faguer, Stanislas, additional, Lebas, Fanny, additional, Demurger, Florence, additional, Emma, Francesco, additional, Cartault, François, additional, Dumont, Geneviève, additional, Godefroid, Nathalie, additional, Guigonis, Vincent, additional, Hillaire, Sophie, additional, Groothoff, Jaap, additional, Dudley, Jan, additional, Jourde-Chiche, Noémie, additional, El Karoui, Khalil, additional, Krid, Saoussen, additional, Coudert, Krier, additional, Bencheick, Larbi, additional, Yver, Laurent, additional, Lavocat, Marie-Pierre, additional, De Sagazan, Le Monies, additional, Leroy, Valerie, additional, Thibaudin, Lise, additional, Ingulli, Liz, additional, Gwanmesia, Lorraine, additional, Burglen, Lydie, additional, Saïd-Menthon, Marie-Hélène, additional, Carrera, Marta, additional, Nizon, Mathilde, additional, Melander, Catherine, additional, Foulard, Michel, additional, Blayo, Monique, additional, Prinseau, Jacques, additional, Jay, Nadine, additional, Brun, Nathalie, additional, Camille, Nicolas, additional, Nobili, François, additional, Devuyst, Olivier, additional, Ben Brahim, Ouafa, additional, Parvex, Paloma, additional, Sabourin, Laurence Perrin, additional, Blanc, Philippe, additional, Vanhille, Philippe, additional, Galichon, Pierre, additional, Pierrepont, Sophie, additional, Planquois, Vincent, additional, Poussard, Gwenaelle, additional, Noble, Claire Pouteil, additional, Allal, Radia, additional, Bernard, Raphaelle, additional, Mounet, Raynaud, additional, Cahen, Rémi, additional, Touraine, Renaud, additional, Rigothier, Claire, additional, Ryckewaert, Amélie, additional, Sacquepee, Mathieu, additional, El Chehadeh, Salima, additional, Samaille, Charlotte, additional, Haq, Shuman, additional, Simckes, Ari, additional, Lanoiselée, Stéphanie, additional, Tellier, Stephanie, additional, Subra, Jean-François, additional, Cloarec, Sylvie, additional, Tenenbam, Julie, additional, Lamy, Thomas, additional, Drouin Garraud, Valérie, additional, Valette, Huguette, additional, Meyssonnier, Vanina, additional, Vargas-Poussou, Rosa, additional, Snajer, Yves, additional, Durault, Sandrine, additional, Plaisier, Emmanuelle, additional, Berard, Etienne, additional, Fakhouri, Fadi, additional, Louillet, Ferielle, additional, Finielz, Paul, additional, Fischbach, Michel, additional, Foliguet, Bernard, additional, Francois-Pradier, Hélène, additional, Garaix, Florentine, additional, Gerard, Marion, additional, Rizzoni, Gianfranco, additional, Gilbert, Brigitte, additional, Glotz, Denis, additional, Dubrasquet, Astrid Godron, additional, Grünfeld, Jean-Pierre, additional, Bollee, Guillaume, additional, Hall, Michelle, additional, Hansson, Sverker, additional, Haye, Damien, additional, Taffin, Hélène, additional, Hildebrandt, Friedhelm, additional, Hourmand, Maryvonne, additional, Kayserili, Hümya, additional, Tack, Ivan, additional, Jacquemont, Marie Line, additional, Fabre-Teste, Jennifer, additional, Kashtan, Cliff, additional, Van Hoeck, Kkoen, additional, Klein, Alexandre, additional, Knefati, Yannick, additional, Knoers, Nine, additional, Konrad, Martin, additional, Lachaux, Alain, additional, Landru, Isabelle, additional, Landthaler, Gilbert, additional, Lang, Philippe, additional, Le Pogamp, Patrick, additional, Legris, Tristan, additional, Didailler, Catherine, additional, Lobbedez, Thierry, additional, de Parscau, Loïc, additional, Pinson, Lucile, additional, Maheut, Hervé, additional, Duval-Arnould, Marc, additional, Rio, Marlène, additional, Gubler, Marie-Claire, additional, Merville, Pierre, additional, Mestrallet, Guillaume, additional, Meunier, Maite, additional, Moreau, Karine, additional, Harambat, Jérôme, additional, Morgan, Graeme, additional, Mourad, Georges, additional, Stuber, Niksic, additional, Boespflug-Tanguy, Odile, additional, Dunand, Olivier, additional, Niel, Olivier, additional, Ouali, Nacera, additional, Malvezzi, Paolo, additional, Abou Jaoude, Pauline, additional, Pelletier, Solenne, additional, Peltier, Julie, additional, Petersen, M.B., additional, Michel, Philippe, additional, Rémy, Philippe, additional, Philit, Jean-Baptiste, additional, Pichault, Valérie, additional, Billette de Villemeur, Thierry, additional, Boudailliez, Bernard, additional, Leheup, Bruno, additional, Dossier, Claire, additional, Djeddi, Djamal-Dine, additional, Berland, Yves, additional, Hurault de Ligny, Bruno, additional, Rigden, Susan, additional, Robino, Christophe, additional, Rossi, Annick, additional, Sarnacki, Sabine, additional, Saidani, Messaoud, additional, Sartorius, Albane Brodin, additional, Schäfer, Elise, additional, Laszlo, Sztriha, additional, Thouret, Marie-Christine, additional, Thuillier-Lecouf, Angélique, additional, Trachtman, Howard, additional, Trivin, Claire, additional, Tsimaratos, Michel, additional, Van Damme-Lombaerts, Rita, additional, Willems, Marjolaine, additional, Youssef, Michel, additional, Zaloszyc, Ariane, additional, Zawodnik, Alexis, additional, and Ziliotis, Marie-Julia, additional

Published
2023
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30. Fibroblast growth factor 23 but not copeptin is independently associated with kidney failure and mortality in patients with chronic kidney disease.

Author

Michon-Colin, Arthur, Metzger, Marie, Bankir, Lise, Gauci, Cédric, Brunel, Mélanie, Baron, Stéphanie, Prot-Bertoye, Caroline, Stengel, Bénédicte, Thervet, Eric, Haymann, Jean-Philippe, Boffa, Jean-Jacques, Vrtovsnik, François, Flamant, Martin, Houillier, Pascal, Prie, Dominique, Courbebaisse, Marie, and Group, for the NephroTest Study

Subjects
FIBROBLAST growth factors, CHRONIC kidney failure, KIDNEY failure, CHRONICALLY ill, GLOMERULAR filtration rate
Abstract

Background Copeptin and intact fibroblast growth factor 23 (iFGF23) increase early during chronic kidney disease (CKD) and may be predictive of unfavourable outcomes. The aim of this study was to evaluate their respective associations with renal and vital outcomes in CKD patients. Methods We included CKD patients from the NephroTest cohort with concomitant measurements of plasma copeptin and iFGF23 concentrations and isotopic glomerular filtration rate measurement (mGFR). The primary endpoint was a composite outcome including kidney failure (KF) (dialysis initiation, pre-emptive transplantation or a 57% decrease of mGFR, corresponding to doubling of serum creatinine) or death before KF. Hazard ratios (HRs) of the primary endpoint associated with log-transformed copeptin and iFGF23 concentrations were estimated by Cox models. The slope of mGFR over time was analysed using a linear mixed model. Results A total of 329 CKD patients (243 men, mean age 60.3 ± 14.6 years) were included. Among them, 301 with an mGFR >15 ml/min/1.73 m2 were included in survival and mGFR slope analyses. During a median follow-up of 4.61 years (quartile 1–quartile 3: 3.72–6.07), 61 KFs and 32 deaths occurred. Baseline iFGF23 concentrations were associated with the composite outcome after multiple adjustments {HR 2.72 [95% confidence interval (CI) 1.85–3.99]}, whereas copeptin concentrations were not [HR 1.01 (95% CI 0.74–1.39)]. Neither copeptin nor iFGF23 were associated with mGFR slope over time. Conclusion Our study shows for the first time in population of CKD patients an independent association between iFGF23 and unfavourable renal and vital outcomes and shows no such association regarding copeptin, encouraging the integration of iFGF23 measurement into the follow-up of CKD. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Triple positive profile in antiphospholipid syndrome: prognosis, relapse and management from a retrospective multicentre study

Author

Laurent, Charlotte, primary, Ricard, Laure, additional, Nguyen, Yann, additional, Boffa, Jean Jacques, additional, Rondeau, Eric, additional, Gerotziafas, Grigorios, additional, Elalamy, Ismail, additional, Deriaz, Sophie, additional, De Moreuil, Claire, additional, Planche, Virginie, additional, Johanet, Cathererine, additional, Millot, Francois, additional, Fain, Olivier, additional, and Mekinian, Arsène, additional

Published
2023
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32. Manifestations non-criteria dans le syndrome des antiphospholipides : une étude cas-témoin multicentrique rétrospective française

Author

Guedon, Alexis, primary, Catano, Jenifer, additional, Ricard, Laure, additional, Laurent, Charlotte, additional, De Moreuil, Claire, additional, Urbanski, Geoffrey, additional, Deriaz, Sophie, additional, Gerotziafas, Grigorios, additional, Elalamy, Ismail, additional, Audemard, Alexandra, additional, Chasset, François, additional, Alamowitch, Sonia, additional, Sellam, Jérémie, additional, Maillot, François, additional, Boffa, Jean-Jacques, additional, Cohen, Ariel, additional, Abisror, Noémie, additional, Fain, Olivier, additional, and Mekinian, Arsène, additional

Published
2023
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33. The Angiogenesis Inhibitor Isthmin-1 (ISM1) Is Overexpressed in Experimental Models of Glomerulopathy and Impairs the Viability of Podocytes

Author

Sahiri, Virgilia, primary, Caron, Jonathan, additional, Roger, Elena, additional, Desterke, Christophe, additional, Ghachem, Khalil, additional, Mohamadou, Inna, additional, Serre, Justine, additional, Prakoura, Niki, additional, Fellahi, Soraya, additional, Placier, Sandrine, additional, Adriouch, Sahil, additional, Zhang, Lu, additional, Chadjichristos, Christos E., additional, Chatziantoniou, Christos, additional, Lorenzo, Hans Kristian, additional, and Boffa, Jean-Jacques, additional

Published
2023
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37. Low Non Relapse Mortality and Good Hematological Response after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma Patients with Renal Insufficiency at Transplant: A Prospective Société Francaise De Greffe De Moelle-Thérapie Cellulaire Observational Study

Author

Garderet, Laurent, primary, Ouldjeriouat, Hafida, additional, Bekadja, Mohamed-Amine, additional, Daguenet, Elisabeth, additional, Vincent, Laure, additional, Roos Weil, Damien, additional, Vignon, Marguerite, additional, Mohty, Mohamad, additional, Abraham, Julie, additional, Escoffre-Barbe, Martine, additional, Lioure, Bruno, additional, Nacer, redhouane Ahmed, additional, Caillot, Denis, additional, Mariette, Clara, additional, Karlin, Lionel, additional, Morel, Pierre, additional, Gilis, Lila, additional, Leray, Emanuelle, additional, Blouet, Anaise, additional, Raus, Nicole, additional, Robin, Marie, additional, Boffa, jean Jacques, additional, Ronco, Pierre, additional, Rubio, Marie Thérèse, additional, Lambert, Jerome, additional, and Cornillon, Jérôme, additional

Published
2022
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38. Clinical and Prognostic Factors in Patients with IgG4-Related Kidney Disease

Author

Chaba, Anis, Devresse, Arnaud, Audard, Vincent, Boffa, Jean Jacques, Karras, Alexandre, Cartery, Claire, Deltombe, Clément, Chemouny, Jonathan, Contamin, Claudine, Courivaud, Cecille, Duquennoy, Simon, Garcia, Hugo, Joly, Dominique, Goumri, Nabila, Hanouna, Guillaume, Halimi, Jean Michel, Plaisier, Emmanuelle, Hamidou, Mohamed, Landron, Cédric, Launay, David, Lebas, Celine, Legendre, Mathieu, Masseau, Agathe, Mathian, Alexis, Mercadal, Lucile, Morel, Nathalie, Mutinelli-Szymanski, Prisca, Palat, Sylvain, Pennaforte, Jean-Loup, Peraldi, Marie Noelle, Pozdzik, Agnieszka, Schleinitz, Nicolas, Thaunat, Olivier, Titeca-Beauport, Dimitri, Mussini, Charlotte, Touati, Sonia, Prinz, Eric, Faller, Anne Laure, Richter, Sarah, Vilaine, Eve, Ferlicot, Sophie, Von-Kotze, Clarissa, Belliere, Julie, Olagne, Jerome, Mesbah, Rafik, Snanoudj, Renaud, Nouvier, Mathilde, Ebbo, Mikael, Zaidan, Mohamad, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, and UCL - (SLuc) Service de néphrologie

Subjects
Transplantation, Nephrology, Epidemiology, Critical Care and Intensive Care Medicine
Published
2023

39. Renal and vascular outcomes in patients with isolated antiphospholipid syndrome nephropathy

Author

Rousselin, Clémentine, primary, Amoura, Zahir, additional, Faguer, Stanislas, additional, Bataille, Pierre, additional, Boffa, Jean-Jacques, additional, Canaud, Guillaume, additional, Guerrot, Dominique, additional, Jourde-Chiche for the GCLR, Noémie, additional, Karras, Alexandre, additional, Auxenfants, Eric, additional, Chapelet, Agnès, additional, Lambert, Marc, additional, Behal, Hélène, additional, Nochy, Dominique, additional, Jean-Paul, Duong Van Huyen, additional, Brocheriou for the CFPR, Isabelle, additional, Gnemmi, Viviane, additional, and Quemeneur, Thomas, additional

Published
2022
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42. Evaluation of the efficacy and safety of Abelmoschus manihot alone and in combination with irbesartan for reduction of albuminuria in patients with type 2 diabetes and diabetic kidney disease.

Author

Zhao Jing, Tostivint, Isabelle, Xu Lingdong, Huang Jihan, Gambotti, Laetitia, Boffa, Jean-Jacques, Yang Min, Wang Ling, Sun Zhuxing, Chen Xiaolan, Liou-Schischmanoff, Amélie, Baumelou, Alain, Ma Teng, Lu Guoyuan, Li Ling, Chen Dai, Piéroni, Laurence, Liu Bingkai, Qin Xiao, and He Weiming

Abstract

Objective To evaluate the efficacy and safety of Abelmoschus manihot (A. Manihot) alone and in combination with irbesartan, for reduction of albuminuria in patients with type 2 diabetic kidney disease. Methods A multicenter randomized double-blind and parallel controlled clinical trial was performed in 9 hospitals of Jiangsu Province (Affiliated Hospital of Nanjing University of Chinese Medicine, First People's Hospital of Changzhou, First People's Hospital of Xuzhou, Wuxi People's Hospital, Affiliated Hospital of Nantong University, Taizhou Hospital of Traditional Chinese Medicine, First Affiliated Hospital of Soochow University, Zhongda Hospital, Southeast University, Changzhou Hospital of Traditional Chinese Medicine) from May 2017 to March 2021. Huangkui capsule, as a traditional Chinese medicine, is made from the ethanol extract of flowers in A. Manihot. All enrolled patients were randomly assigned to the irbesartan group [irbesartan tablets (150 mg/dose, 1 dose/day) +Huangkui capsule simulant (2.5 g/dose, 3 doses/day)], Huangkui capsule group [Huangkui capsule (2.5 g/dose, 3 doses/day) +irbesartan simulant (150 mg/dose, 1 dose/day)], and combined treatment group [irbesartan tablets (150 mg/dose, 1 dose/day) +Huangkui capsule (2.5 g/dose, 3 doses/day)]. The duration of intervention was 24 weeks. Urinary creatinine and urinary albumin were detected at baseline and 24 weeks after treatment, and the urinary albumin-to-creatinine ratio was calculated to observe the change value and rate of UACR compared with baseline. The occurrence of adverse events, adverse reactions, serious adverse events, serious adverse events, and adverse events leading to withdrawal were recorded and the incidence was calculated. One-way analysis of variance (ANOVA), χ² test or Fisher's exact test were used to compare among groups. Results A total of 413 patients with type 2 diabetic kidney disease were included, including 138 in the irbesartan group, 137 in the Huangkui capsule group and 138 in the combined treatment group. After 24 weeks of treatment, the UACR changes of three groups were (-89.07±51.17) mg/g in the irbesartan group, (-146.06±45.52) mg/g in the Huangkui capsule group, and (-262.31±39.08) mg/g in the combined treatment group. The rate of UACR change was (-5.21±6.12)% in the irbesartan group, (-11.89±5.75)% in the Huangkui capsule group, and (-28.56±4.65)% in the combined treatment group, respectively. There were significant differences between the combined treatment group and the irbesartan group in the change value and rate of UACR (P<0.001), while there were no statistical differences between the Huangkui capsule group and irbesartan group (P>0.05). After 24 weeks of treatment, there were no significant differences in the incidence of adverse events, adverse reactions, serious adverse events and serious adverse reactions among the 3 groups (P>0.05). Conclusion The combination of irbesartan and Huangkui capsule can reduce the level of UACR in patients with type 2 diabetic kidney disease, and it shows good efficacy and safety in the treatment of albuminuria in patients with type 2 diabetic kidney disease. [ABSTRACT FROM AUTHOR]

Published
2023
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43. 黄葵胶囊治疗 2 型糖尿病肾脏病患者 白蛋白尿疗效及安全性的临床研究.

Author

赵静, Tostivint Isabelle, 许陵冬, 黄继汉, Gambotti Laetitia, Boffa Jean‑Jacques, 杨敏, 王玲, 孙铸兴, 陈晓岚, Liou‑Schischmanoff Amélie, Baumelou Alain, 马腾, 卢国元, 李玲, 陈岱, Piéroni Laurence, 刘炳凯, 秦笑, and 何伟明

Abstract

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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44. Efficacy of Combined Abelmoschus manihot and Irbesartan for Reduction of Albuminuria in Patients With Type 2 Diabetes and Diabetic Kidney Disease: A Multicenter Randomized Double-Blind Parallel Controlled Clinical Trial

Author

Zhao, Jing, primary, Tostivint, Isabelle, additional, Xu, Lingdong, additional, Huang, Jihan, additional, Gambotti, Laetitia, additional, Boffa, Jean-Jacques, additional, Yang, Min, additional, Wang, Ling, additional, Sun, Zhuxing, additional, Chen, Xiaolan, additional, Liou-Schischmanoff, Amélie, additional, Baumelou, Alain, additional, Ma, Teng, additional, Lu, Guoyuan, additional, Li, Ling, additional, Chen, Dai, additional, Piéroni, Laurence, additional, Liu, Bingkai, additional, Qin, Xiao, additional, He, Weiming, additional, Wang, Yuejuan, additional, Gu, Harvest F., additional, and Sun, Wei, additional

Published
2022
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46. Efficacy and safety of methylprednisolone pulse followed by oral prednisone vs. oral prednisone alone in sarcoidosis tubulointerstitial nephritis: a randomized, open-label, controlled clinical trial.

Author

Mahevas, Matthieu, Audard, Vincent, Rousseau, Alexandra, Cez, Alexandre, Guerrot, Dominique, Verhelst, David, Delahousse, Michel, Hanrotel, Catherine, Pillebout, Evangeline, Daugas, Eric, Krastinova, Evguenia, Valeyre, Dominique, Boffa, Jean-Jacques, and Group, for the GSF French Sarcoidosis

Subjects
SARCOIDOSIS, NEPHRITIS, METHYLPREDNISOLONE, CLINICAL trials, PREDNISONE, GLOMERULAR filtration rate
Abstract

Background We determine the benefit of pulsed methylprednisolone for improving kidney function in patients with sarcoidosis tubulointerstitial nephritis. Methods We conducted a multicenter, prospective, randomized, open-label, controlled trial in patients with biopsy-proven acute tubulointerstitial nephritis caused by sarcoidosis at 21 sites in France. Patients were randomly assigned to receive a methylprednisolone pulse 15 mg/kg/day for 3 days, then oral prednisone (MP group) or oral prednisone 1 mg/kg/day alone (PRD group). The primary end point was a positive response at 3 months, defined as a doubling of estimated glomerular filtration rate (eGFR) compared with the eGFR before randomization. Results We randomized 40 participants. Baseline eGFR before PRD was 22 mL/min/1.73m2 {interquartile range [IQR], 16–44} and before MP was 25 mL/min/1.73m2 (IQR, 22–36) (P  = .3). The two groups did not differ in underlying pathological lesions, including mean percentage of interstitial fibrosis and intensity of interstitial infiltrate. In the intent-to-treat population, the median eGFR at 3 months did not significantly differ between the PRD and MP groups: 45 (IQR, 34–74) and 46 (IQR, 39–65) mL/min/1.73m2. The primary end point at 3 months was achieved in 16 of 20 (80%) PRD patients and 10 of 20 (50%) MP patients (P  = .0467). The eGFR was similar between the two groups after 1, 3, 6, and 12 months of treatment. For both groups, eGFR at 1 month was strongly correlated with eGFR at 12 months (P  < .0001). The two groups did not differ in severe adverse events. Conclusion Compared with a standard oral steroid regimen, intravenous MP may have no supplemental benefit for renal function in patients with tubulointerstitial nephritis caused by sarcoidosis. Trial Registration: ClinicalTrials.gov : NCT01652417; EudraCT: 2012–000149-11 [ABSTRACT FROM AUTHOR]

Published
2023
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47. Management of Undocumented Immigrants With End-Stage Kidney Disease in 2 Academic Hospitals in Paris

Author

Le Flécher, Arnaud, Doreille, Alice, Michel, Pierre-Antoine, Hanouna, Guillaume, Daugas, Eric, Fessi, Hafedh, Claude, Pierre-Abel, Esteve, Emmanuel, Boffa, Jean-Jacques, Strukov, Andrey, Retbi, Aurelia, Petit-Hoang, Camille, François, Hélène, Ouali, Nacera, Jamme, Matthieu, Verney, Charles, Rondeau, Eric, Mesnard, Laurent, Rafat, Cédric, and Luque, Yosu

Published
2022
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49. ANCA-Negative Pauci-immune Necrotizing Glomerulonephritis: A Case Series and a New Clinical Classification

Author

Ronsin, Charles, primary, Georges, Marie, additional, Chapelet-Debout, Agnès, additional, Augusto, Jean-François, additional, Audard, Vincent, additional, Lebourg, Ludivine, additional, Rubin, Sebastien, additional, Quemeneur, Thomas, additional, Bataille, Pierre, additional, Karras, Alexandre, additional, Daugas, Eric, additional, Titeca-Beauport, Dimitri, additional, Boffa, Jean-Jacques, additional, Vigneau, Cécile, additional, Halimi, Jean-Michel, additional, Isnard-Bagnis, Corinne, additional, Durault, Sandrine, additional, Renaudineau, Eric, additional, Bridoux, Frank, additional, Testa, Angelo, additional, Le Quintrec, Moglie, additional, Renaudin, Karine, additional, and Fakhouri, Fadi, additional

Published
2022
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50. Management of undocumented immigrants with end-stage kidney disease in two academic hospitals in Paris

Author

Le Flécher, Arnaud, primary, Doreille, Alice, additional, Michel, Pierre-Antoine, additional, Hanouna, Guillaume, additional, Daugas, Eric, additional, Fessi, Hafedh, additional, Claude, Pierre-Abel, additional, Esteve, Emmanuel, additional, Boffa, Jean-Jacques, additional, Strukov, Andrey, additional, Retbi, Aurelia, additional, Petit-Hoang, Camille, additional, François, Hélène, additional, Ouali, Nacera, additional, Jamme, Matthieu, additional, Verney, Charles, additional, Rondeau, Eric, additional, Mesnard, Laurent, additional, Rafat, Cédric, additional, and Luque, Yosu, additional

Published
2021
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