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114 results on '"Boetzel, K"'

4. The cerebral generator of the colour evoked component N87 of the visual evoked potential: Localization by application of the regional source technique

Author

Plendl, Helmut, Pröckl, D., Schulze, S., Mayer, M., Bötzel, K., Paulus, W., Drum, B., editor, Adams, A. J., editor, Cavonius, C. R., editor, Dain, S. J., editor, Haegerstrom-Portnoy, G., editor, Kitahara, K., editor, Knoblauch, K., editor, Kurtenbach, A., editor, Lee, B. B., editor, Mollon, J., editor, Moreland, J. D., editor, Pokorny, J., editor, Sharpe, L. T., editor, Sperling, H. A., editor, Swanson, W. H., editor, and Zrenner, E., editor

Published
1995
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11. F-18-PI-2620 Tau-PET in Corticobasal Syndrome

Author

Brendel, M., Palleis, C., Prix, C., Finze, A., Boetzel, K., Danek, A., Hoellerhage, M., Beyer, L., Sauerbeck, J., Rauchmann, B., Stephens, A., Drzezga, A., van Eimeren, T., Barthel, H., Patt, M., Sabri, O., Villemagne, V., Bartenstein, P., Perneczky, R., Haass, C., Levin, J., Hoeglinger, G., Brendel, M., Palleis, C., Prix, C., Finze, A., Boetzel, K., Danek, A., Hoellerhage, M., Beyer, L., Sauerbeck, J., Rauchmann, B., Stephens, A., Drzezga, A., van Eimeren, T., Barthel, H., Patt, M., Sabri, O., Villemagne, V., Bartenstein, P., Perneczky, R., Haass, C., Levin, J., and Hoeglinger, G.

Published
2020

12. [18F]PI-2620 Tau PET to Improve Imaging-Based Diagnosis of PSP

Author

Messerschmidt, K., Barthel, H., Brendel, M., Van Eimeren, T., Marek, K., Villemagne, V., Rumpf, J., Saur, D., Schroeter, M., Rullmann, M., Hoffmann, K., Scherlach, C., Rauchmann, B., Schildan, A., Patt, M., Beyer, L., Song, M., Palleis, C., Gehmeyr, M., Fietzek, U., Respondek, G., Sauerbeck, J., Nitschmann, A., Zach, C., Hammes, J., Barbe, M., Onur, O., Jessen, F., Neumaier, B., Barret, O., Madonia, J., Russell, D., Stephens, A., Roeber, S., Herms, J., Boetzel, K., Bartenstein, P., Levin, J., Drzezga, A., Seibyl, J., Hoeglinger, G., Classen, J., Sabri, O., Messerschmidt, K., Barthel, H., Brendel, M., Van Eimeren, T., Marek, K., Villemagne, V., Rumpf, J., Saur, D., Schroeter, M., Rullmann, M., Hoffmann, K., Scherlach, C., Rauchmann, B., Schildan, A., Patt, M., Beyer, L., Song, M., Palleis, C., Gehmeyr, M., Fietzek, U., Respondek, G., Sauerbeck, J., Nitschmann, A., Zach, C., Hammes, J., Barbe, M., Onur, O., Jessen, F., Neumaier, B., Barret, O., Madonia, J., Russell, D., Stephens, A., Roeber, S., Herms, J., Boetzel, K., Bartenstein, P., Levin, J., Drzezga, A., Seibyl, J., Hoeglinger, G., Classen, J., and Sabri, O.

Published
2020

13. Assessment of 18F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy

Author

Brendel, M, Barthel, H, van Eimeren, T, Marek, K, Beyer, L, Song, M, Palleis, C, Gehmeyr, M, Fietzek, U, Respondek, G, Sauerbeck, J, Nitschmann, A, Zach, C, Hammes, J, Barbe, MT, Onur, O, Jessen, F, Saur, D, Schroeter, ML, Rumpf, J-J, Rullmann, M, Schildan, A, Patt, M, Neumaier, B, Barret, O, Madonia, J, Russell, DS, Stephens, A, Roeber, S, Herms, J, Boetzel, K, Classen, J, Bartenstein, P, Villemagne, V, Levin, J, Hoeglinger, GU, Drzezga, A, Seibyl, J, Sabri, O, Brendel, M, Barthel, H, van Eimeren, T, Marek, K, Beyer, L, Song, M, Palleis, C, Gehmeyr, M, Fietzek, U, Respondek, G, Sauerbeck, J, Nitschmann, A, Zach, C, Hammes, J, Barbe, MT, Onur, O, Jessen, F, Saur, D, Schroeter, ML, Rumpf, J-J, Rullmann, M, Schildan, A, Patt, M, Neumaier, B, Barret, O, Madonia, J, Russell, DS, Stephens, A, Roeber, S, Herms, J, Boetzel, K, Classen, J, Bartenstein, P, Villemagne, V, Levin, J, Hoeglinger, GU, Drzezga, A, Seibyl, J, and Sabri, O

Abstract

IMPORTANCE: Progressive supranuclear palsy (PSP) is a 4-repeat tauopathy. Region-specific tau aggregates establish the neuropathologic diagnosis of definite PSP post mortem. Future interventional trials against tau in PSP would strongly benefit from biomarkers that support diagnosis. OBJECTIVE: To investigate the potential of the novel tau radiotracer 18F-PI-2620 as a biomarker in patients with clinically diagnosed PSP. DESIGN, SETTING, AND PARTICIPANTS: In this cross-sectional study, participants underwent dynamic 18F-PI-2620 positron emission tomography (PET) from 0 to 60 minutes after injection at 5 different centers (3 in Germany, 1 in the US, and 1 in Australia). Patients with PSP (including those with Richardson syndrome [RS]) according to Movement Disorder Society PSP criteria were examined together with healthy controls and controls with disease. Four additionally referred individuals with PSP-RS and 2 with PSP-non-RS were excluded from final data analysis owing to incomplete dynamic PET scans. Data were collected from December 2016 to October 2019 and were analyzed from December 2018 to December 2019. MAIN OUTCOMES AND MEASURES: Postmortem autoradiography was performed in independent PSP-RS and healthy control samples. By in vivo PET imaging, 18F-PI-2620 distribution volume ratios were obtained in globus pallidus internus and externus, putamen, subthalamic nucleus, substantia nigra, dorsal midbrain, dentate nucleus, dorsolateral, and medial prefrontal cortex. PET data were compared between patients with PSP and control groups and were corrected for center, age, and sex. RESULTS: Of 60 patients with PSP, 40 (66.7%) had RS (22 men [55.0%]; mean [SD] age, 71 [6] years; mean [SD] PSP rating scale score, 38 [15]; score range, 13-71) and 20 (33.3%) had PSP-non-RS (11 men [55.0%]; mean [SD] age, 71 [9] years; mean [SD] PSP rating scale score, 24 [11]; score range, 11-41). Ten healthy controls (2 men; mean [SD] age, 67 [7] years) and 20 controls with disease (of 10

Published
2020

16. The Search for Face-Specific Evoked Potentials

Author

Bötzel, K., Grüsser, O.-J., Häussler, B., Naumann, A., Başar, Erol, editor, Freeman, W. J., editor, Heiss, W.-D., editor, Lehmann, D., editor, Lopes da Silva, F. H., editor, Speckmann, E.-J., editor, and Bullock, Theodore H., editor

Published
1989
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24. Role of the microlesion effect (MLE) after DBS on simple and ballistic tasks in Parkinson's disease and Dystonia

Author

Singh, A., Kammermeier, S., Boetzel, K., and Mehrkens, J.H.

Subjects
ddc: 610, fungi, DBS, Movements, Bewegungen, respiratory system, 610 Medical sciences, Medicine, Microläsions-Effekt, Microlesion-Effect
Abstract

Objective: Many patients undergoing DBS show an improvement of symptoms right after lead-implantation even before stimulation due to a so-called microlesion effect (MLE), the precise mechanism of which remains unknown. It is assumed that the MLE is caused by inactivation of neurons surrounding the electrode[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Published
2012

25. Basal ganglia oscillations during gait in Parkinson patients

Author

Singh, A, Mehrkens, JH, Kammermeier, S, Plate, A, Ilmberger, J, and Boetzel, K

Subjects
Basalganglien, Oscillations, ddc: 610, genetic structures, Parkinson`s, Parkinson, 610 Medical sciences, Medicine, Oszillationen, Basal Ganglia
Abstract

Objective: Local field potential (LFP) oscillations in the 13–30 Hz frequency band are related to the pathophysiology of the basal ganglia of Parkinson's disease with beta activity in LFP being reduced in PD patients during movement or following medication. The current study was performed[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Published
2012
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27. Microlesion effect (MLE) in the basal ganglia due to deep brain stimulation (DBS) on ballistic movements in Parkinson's and dystonia patients

Author

Singh, A, Boetzel, K, and Mehrkens, JH

Subjects
ddc: 610, nervous system, 610 Medical sciences, Medicine, nervous system diseases
Abstract

Objective: Bradykinesia and hypokinesia are the prominent symptoms of substantia nigra (SN) degeneration in Parkinson's disease (PD), whereas in segmental dystonia, which is characterized by involuntary muscle contractions, normally no bradykinetic or hypokinetic features are seen and the movements[for full text, please go to the a.m. URL], 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

Published
2011
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30. Metaanalysis of chronic pallidal stimulation in children with DYT-1 dystonia

Author

Florian Heinen, Jan Hinnerk Mehrkens, Boetzel K, and Ingo Borggräfe

Subjects
Dystonia, Pediatrics, medicine.medical_specialty, business.industry, General Medicine, Disease, medicine.disease, Penetrance, Dopamine, Pallidal stimulation, Pediatrics, Perinatology and Child Health, Medicine, Neurology (clinical), business, Medical therapy, Severely disabling, medicine.drug
Abstract

Introduction: DYT1-dystonia is an autosomal-dominant disease with a penetrance rate of 3040% and usually starts in childhood between the age 8-12 severely disabling some patients over time. Medical therapy with anti-cholinergic drugs or dopamine is often ineffective and may produce severe side effects. Recent reports suggest that chronic bilateral pallidal stimulation leads to major improvement in these patients.

Published
2008

38. Health-related quality of life and pharmacotherapy in Parkinson's disease: results of a multi-country study of the EuroPA Study Group

Author

Winter, Y, primary, Reese, JP, additional, Campenhausen, S von, additional, Eggert, K, additional, Balzer-Geldsetzer, M, additional, Klotsche, J, additional, Freire, R, additional, Brozova, H, additional, Longo, K, additional, Peter, H, additional, Gasser, J, additional, Seppi, K, additional, Popov, G, additional, Mateus, C, additional, Pfeiffer, KP, additional, Skoupa, J, additional, Boetzel, K, additional, Gusev, E, additional, Guekht, A, additional, Ruzicka, E, additional, Barone, P, additional, Sampaio, C, additional, Poewe, W, additional, Oertel, WH, additional, and Dodel, R, additional

Published
2009
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42. Neuropsychological and psychiatric sequelae of deep-brain stimulation for Parkinson's disease – a randomized, controlled, multicenter study

Author

Daniels, C, primary, Witt, K, additional, Reiff, J, additional, Krack, P, additional, Krause, M, additional, Boetzel, K, additional, Schnitzler, A, additional, Wojtecki, L, additional, Hilker, R, additional, Kalbe, E, additional, Schneider, GH, additional, Kupsch, A, additional, and Deuschl, G, additional

Published
2007
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49. Return to Participation — Significant Improvement after Bilateral Pallidal Stimulation in Rapidly Progressive DYT-1 Dystonia.

Author

Borggraefe, I., Boetzel, K., Boehmer, J., Berweck, S., Mueller-Felber, W., MueIIer, K., Mehrkens, J. H., and Heinen, F.

Subjects
*DYSTONIA, *BRAIN stimulation, *DOPAMINE, *PARASYMPATHOLYTIC agents, *GLOBUS pallidus, *JOINT dislocations
Abstract

We report the case of an 8-year-old girl who developed progressive generalized dystonia, rendering her unable to walk and sit within months despite medical therapy with dopamine and anti-cholinergic agents. She was found to have a 9q34.1 GAG-deletion, which is known to cause DYTI-dystonia. DYT-1 dystonia is an autosomal dominant condition with incomplete penetrance that usually starts in childhood. It is known to be refractory to pharmacotherapy. Reports on deep brain stimulation in this condition reveal marked benefits of the treatment in the pediatric and adult populations. The patient underwent bilateral stimulation of the internal globus pallidus 18 months after symptom onset. Postoperatively, her clinical status improved significantly as measured by the Burke-Fahn- Marsden dystonia rating scale and the resolution of a unilateral hip dislocation. Normal participation was regained. [ABSTRACT FROM AUTHOR]

Published
2008
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