Search

Your search keyword '"Boetto, Julien"' showing total 148 results
Start Over Author "Boetto, Julien"
148 results on '"Boetto, Julien"'

6. Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas

Author

Youngblood, Mark W., Erson-Omay, Zeynep, Li, Chang, Najem, Hinda, Coșkun, Süleyman, Tyrtova, Evgeniya, Montejo, Julio D., Miyagishima, Danielle F., Barak, Tanyeri, Nishimura, Sayoko, Harmancı, Akdes Serin, Clark, Victoria E., Duran, Daniel, Huttner, Anita, Avşar, Timuçin, Bayri, Yasar, Schramm, Johannes, Boetto, Julien, Peyre, Matthieu, Riche, Maximilien, Goldbrunner, Roland, Amankulor, Nduka, Louvi, Angeliki, Bilgüvar, Kaya, Pamir, M. Necmettin, Özduman, Koray, Kilic, Türker, Knight, James R., Simon, Matthias, Horbinski, Craig, Kalamarides, Michel, Timmer, Marco, Heimberger, Amy B., Mishra-Gorur, Ketu, Moliterno, Jennifer, Yasuno, Katsuhito, and Günel, Murat

Published
2023
Full Text
View/download PDF

8. Multimodal management of surgery- and radiation-refractory meningiomas: an analysis of the French national tumor board meeting on meningiomas cohort

Author

Le Van, Tuan, Graillon, Thomas, Jacob, Julian, Vauleon, Elodie, Feuvret, Loic, Boch, Anne-Laure, Boetto, Julien, Boone, Mathieu, Bronnimann, Charlotte, Caire, François, De Barros, Amaury, Delaitre, Mariette, Di Stefano, Anna Luisa, Dore, Mélanie, Ducray, François, Dufour, Christelle, Engelhardt, Julien, Fontaine, Denys, Froelich, Sebastien, Helleringer, Matthieu, Huchet, Aymeri, Joncour, Anthony, Jouanneau, Emmanuel, Mallereau, Charles-Henry, Monfilliette, Apolline, Le Fur, Emmanuelle, Zemmoura, Ilyess, Chinot, Olivier, Sanson, Marc, Kalamarides, Michel, Loiseau, Hugues, and Peyre, Matthieu

Published
2021
Full Text
View/download PDF

9. BRAF and MEK inhibitor targeted therapy in papillary craniopharyngiomas: a cohort study.

Author

Alcubierre, Dario De, Gkasdaris, Grigorios, Mordrel, Margaux, Joncour, Anthony, Briet, Claire, Almairac, Fabien, Boetto, Julien, Mouly, Celine, Larrieu-Ciron, Delphine, Vasiljevic, Alexandre, Villa, Chiara, Sergeant, Camille, Ducray, François, Feuvret, Loic, Chanson, Philippe, Baussart, Bertrand, Raverot, Gerald, and Jouanneau, Emmanuel

Subjects
TERMINATION of treatment, NEOADJUVANT chemotherapy, COMBINED modality therapy, BRAF genes, WEIGHT loss
Abstract

Objective Targeted therapy (TT) with BRAF/MEK inhibitors has emerged as a potential treatment in papillary craniopharyngiomas (PCPs). However, standardized data on large cohorts are lacking. Our study aimed to assess real-life efficacy and safety of BRAF/MEK inhibition in patients with PCPs. Design Retrospective French multicenter study involving BRAF V600E–mutated PCP patients, treated with BRAF/MEK inhibitor combination dabrafenib and trametinib, from April 2019 to July 2023. Methods Objective response and clinical and safety outcomes were assessed after 3 months and at the last available follow-up during TT. Results Sixteen patients (8 females, mean age 50.5 ± 15.75 years), receiving either neoadjuvant therapy (NEO) for non-resectable tumors (n = 6), post-surgical adjuvant therapy (ADJ; n = 8), or palliative therapy (PAL) following failure of multimodal treatment (n = 2), were included. At the last follow-up (mean 7.6 ± 5.3 months), 12 patients showed subtotal response, 3 exhibited partial response, and 1 maintained stable disease. Mean volume reduction was 88.9 ± 4.4%, 73.3 ± 23.4%, and 91.8 ± 4.3% in the NEO, ADJ, and PAL groups, respectively. Targeted therapy resolved headaches in 5/5 patients and visual impairment in 6/9; 2/3 patients had improved neurological symptoms, 1/4 presented weight loss, and 2/14 recovered endocrine function. Targeted therapy was well-tolerated in 62.5% of cases; adverse events led to treatment discontinuation in 5 patients and definitive discontinuation in 3 cases. Conclusions In this study, 94% of patients showed partial response or better to TT. Adverse events were acceptable. Further research is needed to establish standardized protocols; however, these results advocate for a NEO approach in invasive PCPs. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

13. Prognostic impact of the number and total tumor burden of secondary cerebral lesions in patients with resected brain metastases of non–small cell lung cancers

Author

Sauvageot, Sidonie, primary, Mollevi, Caroline, additional, Thomas, Quentin D., additional, Charissoux, Marie, additional, Darlix, Amélie, additional, Rigau, Valérie, additional, Bauchet, Luc, additional, Quantin, Xavier, additional, Pujol, Jean Louis, additional, Roch, Benoit, additional, and Boetto, Julien, additional

Published
2024
Full Text
View/download PDF

14. Descriptive epidemiology of 30,223 histopathologically confirmed meningiomas in France: 2006–2015

Author

Depond, Charles Champeaux, primary, Zouaoui, Sonia, additional, Darlix, Amélie, additional, Rigau, Valérie, additional, Mathieu-Daudé, Hélène, additional, Bauchet, Fabienne, additional, Khettab, Mohamed, additional, Trétarre, Brigitte, additional, Figarella-Branger, Dominique, additional, Taillandier, Luc, additional, Boetto, Julien, additional, Pallud, Johan, additional, Zemmoura, Ilyess, additional, Roche, Pierre-Hugues, additional, and Bauchet, Luc, additional

Published
2023
Full Text
View/download PDF

17. Respective roles of Pik3ca mutations and cyproterone acetate impregnation in mouse meningioma tumorigenesis

Author

Peyre, Matthieu, primary, Comes, Pierre-Cyril, additional, Van, Tuan Le, additional, Tran, Suzanne, additional, Huard, Solène, additional, Abi-Jaoude, Samiya, additional, Venot, Quitterie, additional, Marijon, Pauline, additional, Boetto, Julien, additional, Blouin, Antoine, additional, Bielle, Franck, additional, Ducos, Yohan, additional, Teranishi, Yu, additional, and Kalamarides, Michel, additional

Published
2023
Full Text
View/download PDF

23. Corticosteroids as an Adjuvant Treatment to Surgery in Chronic Subdural Hematomas: A Multi-Center Double-Blind Randomized Placebo-Controlled Trial

Author

Ng, Sam, Boetto, Julien, Huguet, Héléna, Roche, Pierre-Hugues, Fuentes, Stéphane, Lonjon, Michel, Litrico, Stéphane, Barbanel, Anne-Marie, Sabatier, Pascal, Bauchet, Luc, Chevassus, Hugues, Lonjon, Nicolas, Aloy, Emilie, Boniface, Guillaume, Chan-Seng, Emilie, Cochereau, Jérôme, Dufour, Henry, Farah, Kaissar, Fontaine, Denis, Graillon, Thomas, Gras-Combe, Guillaume, Gros, Vanessa, Haynes, William, Khouri, Kifah, Le Corre, Marine, Maillard, André, Paquis, Philippe, Poulen, Gaëtan, Quintard, Adeline, Rodriguez, Marie-Ange, Rolland, Alice, Ros, Maxime, Segnarbieux, François, Suleiman, Nizar, Troude, Lucas, Vassal, Matthieu, Verissimo, Anne-Sophie, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Assistance Publique - Hôpitaux de Marseille (APHM), Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Nice (CHU Nice), Mécanismes moléculaires dans les démences neurodégénératives (MMDN), École Pratique des Hautes Études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)

Subjects
Male, 030506 rehabilitation, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Placebo-controlled study, Head trauma, Double blind, 03 medical and health sciences, 0302 clinical medicine, Chronic subdural hematoma, Double-Blind Method, medicine, Humans, Corticosteroid, Glucocorticoids, Aged, Aged, 80 and over, business.industry, Length of Stay, Middle Aged, Surgery, Clinical trial, Treatment Outcome, Chemotherapy, Adjuvant, Hematoma, Subdural, Chronic, Quality of Life, Prednisone, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), 0305 other medical science, business, Adjuvant, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Chronic subdural hematoma (CSDH) is a common condition necessitating surgery; however, recurrence occurs in 15–25% of cases despite surgical management. The HEMACORT trial was a prospective randomized, double-blind, placebo-controlled, multi-centric study (NCT01380028). The aim of this trial was to determine the effect of corticosteroids as an adjuvant treatment to surgery on CSDH recurrence at 6 months. After surgery, participants were assigned by block-randomization to receive either placebo or oral prednisone at a dose of 1 mg/kg/day followed by weekly stepwise tapering in steps of 10 mg/day. The primary outcome was CSDH recurrence, defined by the need for reoperation and/or radiological progression of CSDH. Secondary outcomes were one-year death, radiological changes, safety, neurological status, and quality of life. The trial was discontinued at midpoint of expected inclusions: 78 participants received prednisone and 77 received placebo controls. In an intention-to-treat analysis, CSDH clinicoradiological recurrence was not different between prednisone and placebo groups (21.8% vs. 35.1%, respectively; hazard ratio 0.56; 95% confidence interval 0.30–1.02; p = 0.06), although post hoc analyses concluded to statistical significance (p = 0.02). Earlier radiological resolution was observed after prednisone administration, but reoperation rates (reaching 5.8% overall) and functional outcomes were not different at 6 months. Among adverse events, sleep disorders occurred more often in the prednisone group (26.1% vs. 9.1%, p = 0.02). The HEMACORT trial data suggest that prednisone, as an adjuvant treatment to surgery, may reduce early radiological recurrence of CSDH, although clinical benefits are unclear. In view of these findings, the authors suggest that shorter treatment duration should be assessed for safety and efficacy in future trials.

Published
2021
Full Text
View/download PDF

24. SomaticPIK3CAMutations in Sporadic Cerebral Cavernous Malformations

Author

Peyre, Matthieu, primary, Miyagishima, Danielle, additional, Bielle, Franck, additional, Chapon, Françoise, additional, Sierant, Michael, additional, Venot, Quitterie, additional, Lerond, Julie, additional, Marijon, Pauline, additional, Abi-Jaoude, Samiya, additional, Le Van, Tuan, additional, Labreche, Karim, additional, Houlston, Richard, additional, Faisant, Maxime, additional, Clémenceau, Stéphane, additional, Boch, Anne-Laure, additional, Nouet, Aurelien, additional, Carpentier, Alexandre, additional, Boetto, Julien, additional, Louvi, Angeliki, additional, and Kalamarides, Michel, additional

Published
2021
Full Text
View/download PDF

28. Respective roles of Pik3camutations and cyproterone acetate impregnation in mouse meningioma tumorigenesis

Author

Cômes, Pierre-Cyril, Le Van, Tuan, Tran, Suzanne, Huard, Solène, Abi-Jaoude, Samiya, Venot, Quitterie, Marijon, Pauline, Boetto, Julien, Blouin, Antoine, Bielle, Franck, Ducos, Yohan, Teranishi, Yu, Kalamarides, Michel, and Peyre, Matthieu

Abstract

Despite their rarity, PIK3CAmutations in meningiomas have raised interest as potentially targetable, ubiquitous mutations owing to their presence in sporadic benign and malignant tumors but also in hormone-related cases. Using new genetically engineered mouse models, we here demonstrate that Pik3camutations in postnatal meningeal cells are sufficient to promote meningioma formation but also tumor progression in mice. Conversely, hormone impregnation, whether alone or in association with Pik3caand Nf2mutations, fails to induce meningioma tumorigenesis while promoting breast tumor formation. We then confirm in vitro the effect of Pik3camutations but not hormone impregnation on the proliferation of primary cultures of mouse meningeal cells. Finally, we show by exome analysis of breast tumors and meninges that hormone impregnation promotes breast tumor formation without additional somatic oncogenic mutation but is associated with an increased mutational burden on Pik3ca-mutant background. Taken together, these results tend to suggest a prominent role of Pik3camutations over hormone impregnation in meningioma tumorigenesis, the exact effect of the latter is still to be discovered.

Published
2023
Full Text
View/download PDF

31. PATH-39. ASSOCIATIONS OF GENOMIC SUBGROUP WITH RECURRENCE IN LOW-GRADE MENINGIOMAS

Author

Youngblood, Mark, primary, Miyagishima, Danielle, additional, Jin, Lan, additional, Gupte, Trisha, additional, Li, Chang, additional, Duran, Daniel, additional, Montejo, Julio, additional, Zhao, Amy, additional, Sheth, Amar, additional, Tyrtova, Evgeniya, additional, Özduman, Koray, additional, Iacoangeli, Francesco, additional, Peyre, Matthieu, additional, Boetto, Julien, additional, Pease, Matthew, additional, Avşar, Timuçin, additional, Huttner, Anita, additional, Bilguvar, Kaya, additional, Kilic, Türker, additional, Pamir, M Necmettiin, additional, Amankulor, Nduka, additional, Kalamarides, Michel, additional, Erson-omay, Zeynep, additional, Gunel, Murat, additional, and Moliterno, Jennifer, additional

Published
2020
Full Text
View/download PDF

32. Correlations between genomic subgroup and clinical features in a cohort of more than 3000 meningiomas

Author

Youngblood, Mark W., primary, Duran, Daniel, additional, Montejo, Julio D., additional, Li, Chang, additional, Omay, Sacit Bulent, additional, Özduman, Koray, additional, Sheth, Amar H., additional, Zhao, Amy Y., additional, Tyrtova, Evgeniya, additional, Miyagishima, Danielle F., additional, Fomchenko, Elena I., additional, Hong, Christopher S., additional, Clark, Victoria E., additional, Riche, Maximilien, additional, Peyre, Matthieu, additional, Boetto, Julien, additional, Sohrabi, Sadaf, additional, Koljaka, Sarah, additional, Baranoski, Jacob F., additional, Knight, James, additional, Zhu, Hongda, additional, Pamir, M. Necmettin, additional, Avşar, Timuçin, additional, Kilic, Türker, additional, Schramm, Johannes, additional, Timmer, Marco, additional, Goldbrunner, Roland, additional, Gong, Ye, additional, Bayri, Yaşar, additional, Amankulor, Nduka, additional, Hamilton, Ronald L., additional, Bilguvar, Kaya, additional, Tikhonova, Irina, additional, Tomak, Patrick R., additional, Huttner, Anita, additional, Simon, Matthias, additional, Krischek, Boris, additional, Kalamarides, Michel, additional, Erson-Omay, E. Zeynep, additional, Moliterno, Jennifer, additional, and Günel, Murat, additional

Published
2020
Full Text
View/download PDF

33. Associations of meningioma molecular subgroup and tumor recurrence

Author

Youngblood, Mark W, primary, Miyagishima, Danielle F, additional, Jin, Lan, additional, Gupte, Trisha, additional, Li, Chang, additional, Duran, Daniel, additional, Montejo, Julio D, additional, Zhao, Amy, additional, Sheth, Amar, additional, Tyrtova, Evgeniya, additional, Özduman, Koray, additional, Iacoangeli, Francesco, additional, Peyre, Matthieu, additional, Boetto, Julien, additional, Pease, Matthew, additional, Avşar, Timuçin, additional, Huttner, Anita, additional, Bilguvar, Kaya, additional, Kilic, Türker, additional, Pamir, M Necmettin, additional, Amankulor, Nduka, additional, Kalamarides, Michel, additional, Erson-Omay, E Zeynep, additional, Günel, Murat, additional, and Moliterno, Jennifer, additional

Published
2020
Full Text
View/download PDF

35. Correlations between genomic subgroup and clinical features in a cohort of more than 3000 meningiomas

Author

Youngblood, Mark W., Duran, Daniel, Montejo, Julio D., Li, Chang, Omay, Sacit Bulent, Ozduman, Koray, Sheth, Amar H., Zhao, Amy Y., Tyrtova, Evgeniya, Miyagishima, Danielle F., Fomchenko, Elena, I, Hong, Christopher S., Clark, Victoria E., Riche, Maximilien, Peyre, Matthieu, Boetto, Julien, Sohrabi, Sadaf, Koljaka, Sarah, Baranoski, Jacob F., Knight, James, Zhu, Hongda, Pamir, M. Necmettin, Avsar, Timucin, Kilic, Turker, Schramm, Johannes, Timmer, Marco, Goldbrunner, Roland, Gong, Ye, Bayri, Yasar, Amankulor, Nduka, Hamilton, Ronald L., Bilguvar, Kaya, Tikhonova, Irina, Tomak, Patrick R., Huttner, Anita, Simon, Matthias, Krischek, Boris, Kalamarides, Michel, Erson-Omay, E. Zeynep, Moliterno, Jennifer, Guenel, Murat, Youngblood, Mark W., Duran, Daniel, Montejo, Julio D., Li, Chang, Omay, Sacit Bulent, Ozduman, Koray, Sheth, Amar H., Zhao, Amy Y., Tyrtova, Evgeniya, Miyagishima, Danielle F., Fomchenko, Elena, I, Hong, Christopher S., Clark, Victoria E., Riche, Maximilien, Peyre, Matthieu, Boetto, Julien, Sohrabi, Sadaf, Koljaka, Sarah, Baranoski, Jacob F., Knight, James, Zhu, Hongda, Pamir, M. Necmettin, Avsar, Timucin, Kilic, Turker, Schramm, Johannes, Timmer, Marco, Goldbrunner, Roland, Gong, Ye, Bayri, Yasar, Amankulor, Nduka, Hamilton, Ronald L., Bilguvar, Kaya, Tikhonova, Irina, Tomak, Patrick R., Huttner, Anita, Simon, Matthias, Krischek, Boris, Kalamarides, Michel, Erson-Omay, E. Zeynep, Moliterno, Jennifer, and Guenel, Murat

Abstract

OBJECTIVE Recent large-cohort sequencing studies have investigated the genomic landscape of meningiomas, identifying somatic coding alterations in NF2, SMARCB1, SMARCE1, TRAF7, KLF4, POLR2A, BAP1, and members of the PI3K and Hedgehog signaling pathways. Initial associations between clinical features and genomic subgroups have been described, including location, grade, and histology. However, further investigation using an expanded collection of samples is needed to confirm previous findings, as well as elucidate relationships not evident in smaller discovery cohorts. METHODS Targeted sequencing of established meningioma driver genes was performed on a multiinstitution cohort of 3016 meningiomas for classification into mutually exclusive subgroups. Relevant clinical information was collected for all available cases and correlated with genomic subgroup. Nominal variables were analyzed using Fisher's exact tests, while ordinal and continuous variables were assessed using Kruskal-Wallis and 1-way ANOVA tests, respectively. Machine-learning approaches were used to predict genomic subgroup based on noninvasive clinical features. RESULTS Genomic subgroups were strongly associated with tumor locations, including correlation of HH tumors with midline location, and non-NF2 tumors in anterior skull base regions. NF2 meningiomas were significantly enriched in male patients, while KLF4 and POLR2A mutations were associated with female sex. Among histologies, the results confirmed previously identified relationships, and observed enrichment of microcystic features among mutation unknown samples. Additionally, KLF4-mutant meningiomas were associated with larger peritumoral brain edema, while SMARCB1 cases exhibited elevated Ki-67 index. Machine-learning methods revealed that observable, noninvasive patient features were largely predictive of each tumor's underlying driver mutation. CONCLUSIONS Using a rigorous and comprehensive approach, this study expands previously described corr

Published
2020

36. Middle meningeal artery embolization as an adjuvant treatment to surgery for symptomatic chronic subdural hematoma: a pilot study assessing hematoma volume resorption

Author

Ng, Sam, primary, Derraz, Imad, additional, Boetto, Julien, additional, Dargazanli, Cyril, additional, Poulen, Gaëtan, additional, Gascou, Gregory, additional, Lefevre, Pierre-Henri, additional, Molinari, Nicolas, additional, Lonjon, Nicolas, additional, and Costalat, Vincent, additional

Published
2019
Full Text
View/download PDF

37. GENE-56. MENINGIOMA GENOMIC SUBGROUP AS A PREDICTOR OF POST-OPERATIVE PATIENT OUTCOMES: IMPLICATIONS FOR TREATMENT AND FOLLOW-UP

Author

Youngblood, Mark, primary, Sheth, Amar, additional, Zhao, Amy, additional, Montejo, Julio, additional, Duran, Daniel, additional, Li, Chang, additional, Tyrtova, Evgeniya, additional, Özduman, Koray, additional, Peyre, Matthieu, additional, Boetto, Julien, additional, Omay, Sacit, additional, Kalamarides, Michel, additional, Zeynep Erson-Omay, E, additional, Günel, Murat, additional, and Moliterno, Jennifer, additional

Published
2019
Full Text
View/download PDF

39. Outcome Analysis Among Meningioma Genomic Subgroups Identifies Decreased Recurrence Free Survival in PI3K Activated Tumors

Author

Youngblood, Mark W, primary, Sheth, Amar, additional, Zhao, Amy, additional, Montejo, Julio D, additional, Duran, Daniel, additional, Li, Chang, additional, Tyrtova, Evgeniya, additional, Ozduman, Koray, additional, Miyagishima, Danielle F, additional, Boetto, Julien, additional, Peyre, Matthieu, additional, Omay, Sacit Bulent, additional, Kalamarides, Michel, additional, Omay, Zeynep E, additional, Gunel, Murat, additional, and Moliterno, Jennifer A, additional

Published
2019
Full Text
View/download PDF

40. Associations of meningioma molecular subgroup and tumor recurrence.

Author

Youngblood, Mark W, Miyagishima, Danielle F, Jin, Lan, Gupte, Trisha, Li, Chang, Duran, Daniel, Montejo, Julio D, Zhao, Amy, Sheth, Amar, Tyrtova, Evgeniya, Özduman, Koray, Iacoangeli, Francesco, Peyre, Matthieu, Boetto, Julien, Pease, Matthew, Avşar, Timuçin, Huttner, Anita, Bilguvar, Kaya, Kilic, Türker, and Pamir, M Necmettin

Published
2021
Full Text
View/download PDF

42. Three‐dimensional printing to compare endoscopic endonasal surgical approaches: A technical note.

Author

Favier, Valentin, Najaf, Yaser, Damecourt, Arnaud, Subsol, Gérard, Captier, Guillaume, Boetto, Julien, and Crampette, Louis

Subjects
THREE-dimensional printing, DACRYOCYSTORHINOSTOMY, INTERNAL carotid artery, SPHENOID bone, PARANASAL sinuses, RESPIRATORY mucosa, HUMAN dissection
Abstract

3D printing allows to precisely replicate the anatomy from CT scan segmentation and to simulate surgical procedures. Nasal septum and sphenoid bone were coated with latex (Gédéo®, Pébéo) to simulate the nasal mucosa. The OETA approach associated the mucosal resection of the SER technique with a 2 cm vertical transfixing incision at the posterior portion of the nasal septum mucosa. [Extracted from the article]

Published
2021
Full Text
View/download PDF

43. Middle meningeal artery embolization as an adjuvant treatment to surgery for symptomatic chronic subdural hematoma: a pilot study assessing hematoma volume resorption.

Author

Ng, Sam, Derraz, Imad, Boetto, Julien, Dargazanli, Cyril, Poulen, Gaëtan, Gascou, Gregory, Lefevre, Pierre-Henri, Molinari, Nicolas, Lonjon, Nicolas, and Costalat, Vincent

Subjects
CHRONIC diseases, CONFIDENCE intervals, RESEARCH funding, STATISTICAL sampling, SUBDURAL hematoma, THERAPEUTIC embolization, PILOT projects, RANDOMIZED controlled trials, DESCRIPTIVE statistics
Abstract

Background Chronic subdural hematoma (CSDH) is a common condition requiring surgical treatment; however, recurrence occurs in 15% of cases at 1 year. Middle meningeal artery (MMA) embolization has recently emerged as a promising treatment to prevent CSDH recurrence. Objective To investigate the effect of MMA embolization on hematoma volume resorption (HVR) after surgery in symptomatic patients. Methods From April 2018 to October 2018, participants with CSDH requiring surgery were prospectively randomized in a pilot study, and received either surgical treatment alone (ST group) or surgery and adjuvant MMA embolization (ST+MMAE group). The primary outcome was HVR measured on the 3 month CT scan compared with the immediate pre-embolization CT scan. Secondary outcomes were clinical recurrence of CSDH and safety measures. Results 46 patients were randomized and 41 of these achieved a 3 month follow-up . Twenty-one patients received MMA embolization. At 3 months, the HVR from postsurgical level was higher in the ST+MMAE group (mean difference 17.5 mL, 95% CI 3.87 to 31.16 mL; p=0.015). Two participants presented a CSDH recurrence (one in each group). One patient died (ST group). No MMA embolization-related adverse events were reported. Conclusion The addition of MMA embolization to surgery led to an increase in CSDH resorption at 3 months. One recurrence of CSDH was reported in each group, and there were no treatment-related complications. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

49. Les auteurs

Author

Roche, Pierre-Hugues, Proust, François, Emery, Évelyne, Vassal, François, Almairac, Fabien, Amelot, Aymeric, Anthérieu, Pierre, Barrey, Cédric, Beccaria, Kevin, Beuriat, Pierre-Aurélien, Boetto, Julien, Buffenoir, Kevin, Caire, François, Cebula, Hélène, Colnat-Coulbois, Sophie, Di Rocco, Federico, Gaberel, Thomas, Gilard, Vianney, Goutagny, Stéphane, Graillon, Thomas, Kleiber, Jean-Charles, Klein, Olivier, Magro, Elsa, Pallud, Johan, Rigoard, Philippe, de Saint-Denis, Timothée, Seizeur, Romuald, Simon, Émile, Tetard, Marie-Charlotte, Thines, Laurent, Todeschi, Julien, Troude, Lucas, Vignes, Jean-Rodolphe, and Zemmoura, Ilyess

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results