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30. TARAVANA SYNDROME: A CASE REPORT

Author

Piccillo, G, Consolo, Em, Mondati, Enrico, Boemi, Pm, Polosa, R, Manfre', L, Miele, L, and Gasbarrini, G.

Published
2006

33. Ferro e ferrodeplezione nell'epatite cronica HCV-correlata

Author

Bertino, Gaetano, Ardiri, Am, Sciuto, M, Ierna, D, Bruno, Cosimo Marcello, Valenti, M, Fisichella, Alfredo, Boemi, Pm, Urso, G, Interlandi, D, Puglisi, M, Santonocito, Mm, DI PRIMA, P, Calvagno, G. S., Pulvirenti, D, and Neri, Sergio

Published
2006

47. Prognostic and diagnostic value of des-γ-carboxy prothrombin in liver cancer.

Author

Bertino G, Ardiri AM, Calvagno GS, Bertino N, and Boemi PM

Subjects
Animals, Biomarkers, Tumor blood, Carcinoma, Hepatocellular pathology, Humans, Liver Neoplasms pathology, Neoplasm Metastasis, Neoplasm Recurrence, Local diagnosis, Prognosis, Prothrombin, Sensitivity and Specificity, alpha-Fetoproteins metabolism, Biomarkers blood, Carcinoma, Hepatocellular diagnosis, Liver Neoplasms diagnosis, Protein Precursors blood
Abstract

Des-γ-carboxy prothrombin (DCP) is an abnormal prothrombin induced by the absence of vitamin K₂ that is increased in the serum of patients with hepatocellular carcinoma (HCC). In hepatoma cells, genetic alterations, membrane receptors, the inability to uptake labeled low-density lipoprotein, cytoskeletal changes and hepatocyte cytoplasmic transfers involved in vitamin K metabolism could play an important role in producing detectable DCP serum levels. Serum DCP was found to have a sensitivity ranging from 48% to 62%, a specificity of 81% to 98% and a diagnostic accuracy of 59% to 84% for detecting HCC. Plasma DCP does not correlate with α-fetoprotein (AFP) levels. However, when used together, the DCP and AFP assays increase the sensitivity of detecting HCC in more than 85% of patients. The specificity of the DCP assay appears to be superior to that of AFP. These biomarkers can complement ultrasound for early HCC detection, but neither DCP nor AFP is optimal. For small HCC, a high preoperative DCP level appears to be indicative of tumor recurrence. Recently, there has been attention given to DCP because of its role in detecting HCC recurrence after living donor liver transplant. More recent research has demonstrated that DCP stimulates human vascular endothelial cell growth and migration. All the data presented above demonstrate the importance of DCP in formulating a prognosis for patients with HCC., (Copyright 2010 Prous Science, S.A.U. or its licensors. All rights reserved.)

Published
2010
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48. Epoetin alpha improves the response to antiviral treatment in HCV-related chronic hepatitis.

Author

Bertino G, Ardiri A, Boemi PM, Calvagno GS, Ruggeri IM, Speranza A, Santonocito MM, Ierna D, Bruno CM, Valenti M, Boemi R, Naimo S, and Neri S

Subjects
Adult, Anemia, Hypochromic chemically induced, Drug Administration Schedule, Drug Therapy, Combination, Epoetin Alfa, Female, Ferritins blood, Hemoglobins metabolism, Hepacivirus drug effects, Hepacivirus genetics, Hepacivirus isolation & purification, Humans, Interferon alpha-2, Interferon-alpha administration & dosage, Interferon-alpha adverse effects, Longitudinal Studies, Male, Middle Aged, Polyethylene Glycols administration & dosage, Polyethylene Glycols adverse effects, Prospective Studies, Quality of Life, RNA, Viral analysis, Recombinant Proteins, Ribavirin administration & dosage, Ribavirin adverse effects, Treatment Outcome, Viral Load, Anemia, Hypochromic drug therapy, Antiviral Agents administration & dosage, Antiviral Agents adverse effects, Erythropoietin therapeutic use, Hematinics therapeutic use, Hepatitis C, Chronic drug therapy
Abstract

Background: The conventional antiviral treatment of chronic hepatitis related to hepatitis C virus (HCV) often leads to anemia. In this case, it is necessary to reduce ribavirin dose or stop treatment, thus reducing the rate of sustained virological response., Aim: We investigated whether epoetin alpha administration improves treatment adherence and leads to higher percentage of response at the end of therapy and sustained virological response., Methods: Two hundred and fourteen individuals with genotype 1b HCV-related chronic hepatitis underwent treatment with pegylated (peg)-interferon alpha-2A 180 μg once weekly and ribavirin 1,000-1,200 mg/day; 174 were responders. Forty individuals completed treatment with no hemoglobin reduction; 134 developed anemia during therapy. Anemic responders were distributed randomly into two groups: group 1 continued therapy with epoetin alpha addiction; group 2 continued antiviral therapy with ribavirin reduction only., Results: Patients in group 1 achieved better control of hemoglobin levels (13.8 ± 1.2 g/dl at the end of therapy) than those in group 2 (11.5 ± 0.8 g/dl). Sustained virological response was 59.7% in group 1 compared with 34.4% in group 2 (p<0.01)., Conclusions: In patients with 1b HCV-related chronic hepatitis who develop anemia during antiviral treatment, administration of epoetin alpha increases hemoglobin levels and the end-of-treatment rate and sustains virological response by improving treatment adherence.

Published
2010
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49. In chronic viral hepatitis without malignancy, abnormal serum carbohydrate 19-9 antigen levels are associated with liver disease severity and are related to different viral aetiology.

Author

Bertino G, Ardiri AM, Calvagno GS, and Boemi PM

Subjects
Biomarkers blood, Biopsy, CA-19-9 Antigen immunology, Disease Progression, Female, Hepatitis B, Chronic blood, Hepatitis B, Chronic virology, Hepatitis C, Chronic blood, Hepatitis C, Chronic virology, Humans, Male, Middle Aged, Prognosis, Severity of Illness Index, CA-19-9 Antigen blood, Hepacivirus immunology, Hepatitis B virus immunology, Hepatitis B, Chronic immunology, Hepatitis C, Chronic immunology, Liver pathology, Liver virology
Published
2010
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50. Some patients with HCC haven't abnornormal des-gamma-carboxy prothrombin and alpha-fetoprotein levels.

Author

Bertino G, Ardiri AM, Santonocito MM, and Boemi PM

Subjects
Carcinoma, Hepatocellular diagnosis, Carcinoma, Hepatocellular pathology, Humans, Liver Neoplasms diagnosis, Liver Neoplasms pathology, Neoplasm Staging, Predictive Value of Tests, Prognosis, Prothrombin, Sensitivity and Specificity, Biomarkers blood, Carcinoma, Hepatocellular blood, Liver Neoplasms blood, Protein Precursors blood, alpha-Fetoproteins analysis
Published
2009

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