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2. Accuracy and tolerability of self-sampling of capillary blood for analysis of inflammation and autoantibodies in rheumatoid arthritis patients—results from a randomized controlled trial

Author

Knitza, Johannes, Tascilar, Koray, Vuillerme, Nicolas, Eimer, Ekaterina, Matusewicz, Paul, Corte, Giulia, Schuster, Louis, Aubourg, Timothée, Bendzuck, Gerlinde, Korinth, Marianne, Elling-Audersch, Corinna, Kleyer, Arnd, Boeltz, Sebastian, Hueber, Axel J., Krönke, Gerhard, Schett, Georg, and Simon, David

Published
2022
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5. To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

Author

Boeltz, Sebastian, Amini, Poorya, Anders, Hans-Joachim, Andrade, Felipe, Bilyy, Rostyslav, Chatfield, Simon, Cichon, Iwona, Clancy, Danielle M., Desai, Jyaysi, Dumych, Tetiana, Dwivedi, Nishant, Gordon, Rachael Ann, Hahn, Jonas, Hidalgo, Andrés, Hoffmann, Markus H., Kaplan, Mariana J., Knight, Jason S., Kolaczkowska, Elzbieta, Kubes, Paul, Leppkes, Moritz, Manfredi, Angelo A., Martin, Seamus J., Maueröder, Christian, Maugeri, Norma, Mitroulis, Ioannis, Munoz, Luis E., Nakazawa, Daigo, Neeli, Indira, Nizet, Victor, Pieterse, Elmar, Radic, Marko Z, Reinwald, Christiane, Ritis, Konstantinos, Rovere-Querini, Patrizia, Santocki, Michal, Schauer, Christine, Schett, Georg, Shlomchik, Mark Jay, Simon, Hans-Uwe, Skendros, Panagiotis, Stojkov, Darko, Vandenabeele, Peter, Berghe, Tom Vanden, van der Vlag, Johan, Vitkov, Ljubomir, von Köckritz-Blickwede, Maren, Yousefi, Shida, Zarbock, Alexander, and Herrmann, Martin

Published
2019
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6. Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells

Author

Bergmann, Christina, primary, Müller, Fabian, additional, Distler, Jörg H W, additional, Györfi, Andrea-Hermina, additional, Völkl, Simon, additional, Aigner, Michael, additional, Kretschmann, Sascha, additional, Reimann, Hannah, additional, Harrer, Thomas, additional, Bayerl, Nadine, additional, Boeltz, Sebastian, additional, Wirsching, Andreas, additional, Taubmann, Jule, additional, Rösler, Wolf, additional, Spriewald, Bernd, additional, Wacker, Jochen, additional, Atzinger, Armin, additional, Uder, Michael, additional, Kuwert, Torsten, additional, Mackensen, Andreas, additional, and Schett, Georg, additional

Published
2023
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7. CD19-targeted CAR T cells in refractory antisynthetase syndrome

Author

Müller, Fabian, primary, Boeltz, Sebastian, additional, Knitza, Johannes, additional, Aigner, Michael, additional, Völkl, Simon, additional, Kharboutli, Soraya, additional, Reimann, Hannah, additional, Taubmann, Jule, additional, Kretschmann, Sascha, additional, Rösler, Wolf, additional, Manger, Bernhard, additional, Wacker, Jochen, additional, Mougiakakos, Dimitrios, additional, Jabari, Samir, additional, Schröder, Rolf, additional, Uder, Michael, additional, Roemer, Frank, additional, Krönke, Gerhard, additional, Mackensen, Andreas, additional, and Schett, Georg, additional

Published
2023
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10. CD19-Targeted CAR-T Cells in Refractory Systemic Lupus Erythematosus: Safety, Efficacy, and Mechanistic Insights from the First Five Patients

Author

Mueller, Fabian, primary, Voelkl, Simon, additional, Mougiakakos, Dimitrios, additional, Boeltz, Sebastian, additional, Aigner, Michael, additional, Gary, Regina, additional, Kretschmann, Sascha, additional, Kharboutli, Soraya, additional, Kleyer, Arnd, additional, Simon, David, additional, Rösler, Wolf, additional, Habenicht, Katharina M., additional, Winkler, Thomas H., additional, Krönke, Gerhard, additional, Schett, Georg, additional, and Mackensen, Andreas, additional

Published
2022
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11. Digitally supported shared decision-making and treat-to-target in rheumatology: a qualitative study embedded in a multicenter randomized controlled trial

Author

Muehlensiepen, Felix, primary, May, Susann, additional, Hadaschik, Katharina, additional, Vuillerme, Nicolas, additional, Heinze, Martin, additional, Grahammer, Manuel, additional, Labinsky, Hannah, additional, Boeltz, Sebastian, additional, Detert, Jacqueline, additional, Petersen, Jana, additional, Krönke, Gerhard, additional, Schett, Georg, additional, and Knitza, Johannes, additional

Published
2022
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12. Remote self-collection of capillary blood using upper arm devices for autoantibody analysis in patients with immune-mediated inflammatory rheumatic diseases

Author

Zarbl, Joshua, primary, Eimer, Ekaterina, additional, Gigg, Camilla, additional, Bendzuck, Gerlinde, additional, Korinth, Marianne, additional, Elling-Audersch, Corinna, additional, Kleyer, Arnd, additional, Simon, David, additional, Boeltz, Sebastian, additional, Krusche, Martin, additional, Mucke, Johanna, additional, Muehlensiepen, Felix, additional, Vuillerme, Nicolas, additional, Krönke, Gerhard, additional, Schett, Georg, additional, and Knitza, Johannes, additional

Published
2022
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13. Rescue therapy of antisynthetase syndrome with CD19-targeted CAR-T cells after failure of several B-cell depleting antibodies.

Author

Taubmann, Jule, Knitza, Johannes, Müller, Fabian, Völkl, Simon, Aigner, Michael, Kleyer, Arnd, Gary, Regina, Kretschmann, Sascha, Boeltz, Sebastian, Atzinger, Armin, Kuwert, Torsten, Roemer, Frank, Uder, Michael, Mackensen, Andreas, and Schett, Georg

Subjects
THERAPEUTIC use of monoclonal antibodies, C-reactive protein, IMMUNOGLOBULINS, CHEST X rays, INTRAVENOUS therapy, ANTISYNTHETASE syndrome, SERODIAGNOSIS, CREATINE kinase, MAGNETIC resonance imaging, POSITRON emission tomography computed tomography, TREATMENT failure, FLUDARABINE, PULMONARY function tests, CYCLOPHOSPHAMIDE, T cells, ARTHRITIS, COMPUTED tomography, IMMUNOTHERAPY
Abstract

The article describes the case of a 44-year-old Caucasian woman with severe refractory antisynthetase syndrome (ASS). Topics discussed include typical manifestations of ASS in the patient, reason for initiating CAR-T cell treatment, and symptoms developed by the patient one week after CAR-T cell administration.

Published
2024
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14. Patient's Perception of Digital Symptom Assessment Technologies in Rheumatology: Results From a Multicentre Study

Author

Knitza, Johannes, Muehlensiepen, Felix, Ignatyev, Yuriy, Fuchs, Franziska, Mohn, Jacob, Simon, David, Kleyer, Arnd, Fagni, Filippo, Boeltz, Sebastian, Morf, Harriet, Bergmann, Christina, Labinsky, Hannah, Vorbrüggen, Wolfgang, Ramming, Andreas, Distler, Jörg H. W., Bartz-Bazzanella, Peter, Vuillerme, Nicolas, Schett, Georg, Welcker, Martin, and Hueber, Axel J.

Subjects
Male, Rheumatology, Artificial Intelligence, Public Health, Environmental and Occupational Health, Humans, Female, Perception, Prospective Studies, ddc:610, Middle Aged, Symptom Assessment
Abstract

IntroductionAn increasing number of digital tools, including dedicated diagnostic decision support systems (DDSS) exist to better assess new symptoms and understand when and where to seek medical care. The aim of this study was to evaluate patient's previous online assessment experiences and to compare the acceptability, usability, usefulness and potential impact of artificial intelligence (AI)-based symptom checker (Ada) and an online questionnaire-based self-referral tool (Rheport).Materials and MethodsPatients newly presenting to three German secondary rheumatology outpatient clinics were randomly assigned in a 1:1 ratio to complete consecutively Ada or Rheport in a prospective non-blinded multicentre controlled crossover randomized trial. DDSS completion time was recorded by local study personnel and perceptions on DDSS and previous online assessment were collected through a self-completed study questionnaire, including usability measured with the validated System Usability Scale (SUS).Results600 patients (median age 52 years, 418 women) were included. 277/600 (46.2%) of patients used an online search engine prior to the appointment. The median time patients spent assessing symptoms was 180, 7, and 8 min, respectively using online using search engines, Ada and Rheport. 111/275 (40.4%), 266/600 (44.3%) and 395/600 (65.8%) of patients rated the respective symptom assessment as very helpful or helpful, using online search engines, Ada and Rheport, respectively. Usability of both diagnostic decision support systems (DDSS) was “good” with a significantly higher mean SUS score (SD) of Rheport 77.1/100 (16.0) compared to Ada 74.4/100 (16.8), (p < 0.0001). In male patients, usability of Rheport was rated higher than Ada (p = 0.02) and the usability rating of older (52 years ≥) patients of both DDSS was lower than in younger participants (p = 0.005). Both effects were independent of each other. 440/600 (73.3%) and 475/600 (79.2%) of the patients would recommend Ada and Rheport to friends and other patients, respectively.ConclusionIn summary, patients increasingly assess their symptoms independently online, however only a minority used dedicated symptom assessment websites or DDSS. DDSS, such as Ada an Rheport are easy to use, well accepted among patients with musculoskeletal complaints and could replace online search engines for patient symptom assessment, potentially saving time and increasing helpfulness.

Published
2022

15. Additional file 2 of Accuracy and tolerability of self-sampling of capillary blood for analysis of inflammation and autoantibodies in rheumatoid arthritis patients—results from a randomized controlled trial

Author

Knitza, Johannes, Tascilar, Koray, Vuillerme, Nicolas, Eimer, Ekaterina, Matusewicz, Paul, Corte, Giulia, Schuster, Louis, Aubourg, Timothée, Bendzuck, Gerlinde, Korinth, Marianne, Elling-Audersch, Corinna, Kleyer, Arnd, Boeltz, Sebastian, Hueber, Axel J., Krönke, Gerhard, Schett, Georg, and Simon, David

Abstract

Additional file 2: Fig. S2. Intraclass correlation coefficients and 95% confidence interval by group and analyte

Published
2022
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16. Additional file 1 of Accuracy and tolerability of self-sampling of capillary blood for analysis of inflammation and autoantibodies in rheumatoid arthritis patients—results from a randomized controlled trial

Author

Knitza, Johannes, Tascilar, Koray, Vuillerme, Nicolas, Eimer, Ekaterina, Matusewicz, Paul, Corte, Giulia, Schuster, Louis, Aubourg, Timothée, Bendzuck, Gerlinde, Korinth, Marianne, Elling-Audersch, Corinna, Kleyer, Arnd, Boeltz, Sebastian, Hueber, Axel J., Krönke, Gerhard, Schett, Georg, and Simon, David

Abstract

Additional file 1: Fig. S1. Self-sampling feasibility results according to randomization arm

Published
2022
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17. Patient's Perception of Digital Symptom Assessment Technologies in Rheumatology: Results From a Multicentre Study

Author

Knitza, Johannes, primary, Muehlensiepen, Felix, additional, Ignatyev, Yuriy, additional, Fuchs, Franziska, additional, Mohn, Jacob, additional, Simon, David, additional, Kleyer, Arnd, additional, Fagni, Filippo, additional, Boeltz, Sebastian, additional, Morf, Harriet, additional, Bergmann, Christina, additional, Labinsky, Hannah, additional, Vorbrüggen, Wolfgang, additional, Ramming, Andreas, additional, Distler, Jörg H. W., additional, Bartz-Bazzanella, Peter, additional, Vuillerme, Nicolas, additional, Schett, Georg, additional, Welcker, Martin, additional, and Hueber, Axel J., additional

Published
2022
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18. Remote self-collection of capillary blood using upper arm devices for autoantibody analysis in patients with immunemediated inflammatory rheumatic diseases.

Author

Zarbl, Joshua, Eimer, Ekaterina, Gigg, Camilla, Bendzuck, Gerlinde, Korinth, Marianne, Elling-Audersch, Corinna, Kleyer, Arnd, Simon, David, Boeltz, Sebastian, Krusche, Martin, Mucke, Johanna, Muehlensiepen, Felix, Vuillerme, Nicolas, Krönke, Gerhard, Schett, Georg, and Knitza, Johannes

Published
2022
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19. Neutrophil Extracellular Traps Initiate Gallstone Formation

Author

Muñoz, Luis E., Boeltz, Sebastian, Bilyy, Rostyslav, Schauer, Christine, Mahajan, Aparna, Widulin, Navena, Grüneboom, Anika, Herrmann, Irmgard, Boada, Edgyda, Rauh, Manfred, Krenn, Veit, Biermann, Mona H.C., Podolska, Malgorzata J., Hahn, Jonas, Knopf, Jasmin, Maueröder, Christian, Paryzhak, Solomiya, Dumych, Tetiana, Zhao, Yi, Neurath, Markus F., Hoffmann, Markus H., Fuchs, Tobias A., Leppkes, Moritz, Schett, Georg, and Herrmann, Martin

Published
2019
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20. Autoimmune, rheumatic, chronic inflammatory diseases: Neutrophil Extracellular Traps on Parade

Author

Podolska, Malgorzata, Mahajan, Aparna, Knopf, Jasmin, Hahn, Jonas, Boeltz, Sebastian, Munoz, Luis, Bilyy, Rostyslav, and Herrmann, Martin

Subjects
ddc:616, Medizinische Fakultät
Abstract

Rheumatic diseases are a group of inflammatory conditions that affect joints and connective tissues and are often accompanied by pain and restriction of motility. In many of these diseases autoantibodies develop that react with molecules/structures commonly found hidden in neutrophils. Neutrophil extracellular trap (NET)formation and release is considered a defense mechanism against pathogens or endogenous danger signals and it has been associated with initial inflammatory responses. NETs are also endowed with an important resolution potential based on its intrinsic enzymatic activity, but in the case they are not timely removed from the crime scene they might modulate subsequent immune responses and contribute to the pathogenesis of chronic inflammatory diseases. In this review we will summarize the actual knowledge about the multifaceted roles of NETs in the etiology and pathogenesis of rheumatic autoimmune diseases.

Published
2018

23. Cleaved N-terminal histone tails distinguish between NADPH oxidase (NOX)-dependent and NOX-independent pathways of neutrophil extracellular trap formation

Author

Pieterse, Elmar, primary, Rother, Nils, additional, Yanginlar, Cansu, additional, Gerretsen, Jelle, additional, Boeltz, Sebastian, additional, Munoz, Luis Enrique, additional, Herrmann, Martin, additional, Pickkers, Peter, additional, Hilbrands, Luuk B, additional, and van der Vlag, Johan, additional

Published
2018
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24. Autoantibodies Recognizing Secondary NEcrotic Cells Promote Neutrophilic Phagocytosis and Identify Patients With Systemic Lupus Erythematosus

Author

Biermann, Mona H. C., primary, Boeltz, Sebastian, additional, Pieterse, Elmar, additional, Knopf, Jasmin, additional, Rech, Jürgen, additional, Bilyy, Rostyslav, additional, van der Vlag, Johan, additional, Tincani, Angela, additional, Distler, Jörg H. W., additional, Krönke, Gerhard, additional, Schett, Georg Andreas, additional, Herrmann, Martin, additional, and Muñoz, Luis E., additional

Published
2018
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25. Autoantibodies Recognizing Secondary NEcrotic Cells Promote Neutrophilic Phagocytosis and Identify Patients With Systemic Lupus Erythematosus

Author

Biermann, M.H., Boeltz, Sebastian, Pieterse, E., Knopf, Jasmin, Rech, Juergen, Bilyy, R., Vlag, J. van der, Herrmann, M., Munoz, L.E., Biermann, M.H., Boeltz, Sebastian, Pieterse, E., Knopf, Jasmin, Rech, Juergen, Bilyy, R., Vlag, J. van der, Herrmann, M., and Munoz, L.E.

Abstract

Contains fulltext : 191427.pdf (publisher's version ) (Open Access)

Published
2018

26. Cleaved N-terminal histone tails distinguish between NADPH oxidase (NOX)-dependent and NOX-independent pathways of neutrophil extracellular trap formation

Author

Pieterse, E., Rother, N, Yanginlar, C., Gerretsen, J., Boeltz, Sebastian, Munoz, Luis Enrique, Pickkers, P., Hilbrands, L.B., Vlag, J. van der, Pieterse, E., Rother, N, Yanginlar, C., Gerretsen, J., Boeltz, Sebastian, Munoz, Luis Enrique, Pickkers, P., Hilbrands, L.B., and Vlag, J. van der

Abstract

Contains fulltext : 199004.pdf (publisher's version ) (Closed access)

Published
2018

32. Effect of UBE2L3genotype on regulation of the linear ubiquitin chain assembly complex in systemic lupus erythematosus

Author

Lewis, Myles, Vyse, Simon, Shields, Adrian, Boeltz, Sebastian, Gordon, Patrick, Spector, Timothy, Lehner, Paul, Walczak, Henning, and Vyse, Timothy

Abstract

A single risk haplotype across UBE2L3is strongly associated with systemic lupus erythematosus (SLE) and many other autoimmune diseases. UBE2L3 is an E2 ubiquitin-conjugating enzyme with specificity for RING-in-between-RING E3 ligases, including HOIL-1 and HOIP, components of the linear ubiquitin chain assembly complex (LUBAC), which has a pivotal role in inflammation, through crucial regulation of NF-κB. We aimed to determine whether UBE2L3 regulates LUBAC-mediated activation of NF-κB, and determine the effect of UBE2L3genotype on NF-κB activation and B-cell differentiation.

Published
2015
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33. To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

Author

Jyaysi Desai, Markus H. Hoffmann, Poorya Amini, Nishant Dwivedi, Panagiotis Skendros, Ioannis Mitroulis, Christian Maueröder, Iwona Cichon, Darko Stojkov, Christine Schauer, Martin Herrmann, Maren von Köckritz-Blickwede, Elmar Pieterse, Rostyslav Bilyy, Peter Vandenabeele, Moritz Leppkes, Angelo A. Manfredi, Daigo Nakazawa, Ljubomir Vitkov, Norma Maugeri, Marko Z. Radic, Elzbieta Kolaczkowska, Christiane Reinwald, Shida Yousefi, Konstantinos Ritis, Rachael A. Gordon, Tetiana Dumych, Sebastian Boeltz, Indira Neeli, Georg Schett, Simon Chatfield, Tom Vanden Berghe, Mark J. Shlomchik, Jason S. Knight, Andrés Hidalgo, Felipe Andrade, Johan van der Vlag, Hans-Joachim Anders, Jonas Hahn, Alexander Zarbock, Danielle M. Clancy, Victor Nizet, Luis E. Muñoz, Patrizia Rovere-Querini, Michal Santocki, Seamus J. Martin, Mariana J. Kaplan, Hans-Uwe Simon, Paul Kubes, Boeltz, Sebastian, Amini, Poorya, Anders, Hans-Joachim, Andrade, Felipe, Bilyy, Rostyslav, Chatfield, Simon, Cichon, Iwona, Clancy, Danielle M., Desai, Jyaysi, Dumych, Tetiana, Dwivedi, Nishant, Gordon, Rachael Ann, Hahn, Jona, Hidalgo, André, Hoffmann, Markus H., Kaplan, Mariana J., Knight, Jason S., Kolaczkowska, Elzbieta, Kubes, Paul, Leppkes, Moritz, Manfredi, Angelo A., Martin, Seamus J., Maueröder, Christian, Maugeri, Norma, Mitroulis, Ioanni, Munoz, Luis E., Nakazawa, Daigo, Neeli, Indira, Nizet, Victor, Pieterse, Elmar, Radic, Marko Z, Reinwald, Christiane, Ritis, Konstantino, Rovere-Querini, Patrizia, Santocki, Michal, Schauer, Christine, Schett, Georg, Shlomchik, Mark Jay, Simon, Hans-Uwe, Skendros, Panagioti, Stojkov, Darko, Vandenabeele, Peter, Berghe, Tom Vanden, van der Vlag, Johan, Vitkov, Ljubomir, von Köckritz-Blickwede, Maren, Yousefi, Shida, Zarbock, Alexander, and Herrmann, Martin

Subjects
0301 basic medicine, Neutrophils, Review Article, Extracellular Traps, 03 medical and health sciences, 0302 clinical medicine, Research community, Political science, medicine, Humans, State of the science, 610 Medicine & health, Molecular Biology, Biology, Confusion, Cognitive science, Extramural, Cell Biology, Neutrophil extracellular traps, Chemistry, 030104 developmental biology, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], 030220 oncology & carcinogenesis, Human medicine, medicine.symptom, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11]
Abstract

Item does not contain fulltext Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics and physiological functions of NETs have been uncovered. Nowadays, the field continues to expand and novel mechanisms that orchestrate formation of NETs, their previously unknown properties, and novel implications in disease continue to emerge. The abundance of available data has also led to some confusion in the NET research community due to contradictory results and divergent scientific concepts, such as pro- and anti-inflammatory roles in pathologic conditions, demarcation from other forms of cell death, or the origin of the DNA that forms the NET scaffold. Here, we present prevailing concepts and state of the science in NET-related research and elaborate on open questions and areas of dispute.

Published
2019

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