1. Low-intensity vestibular noise stimulation improves postural symptoms in progressive supranuclear palsy.
- Author
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Wuehr, Max, Peto, Daniela, Fietzek, Urban M., Katzdobler, Sabrina, Nübling, Georg, Zaganjori, Mirlind, Brendel, Matthias, Levin, Johannes, Höglinger, Günter U., and Zwergal, Andreas
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PROGRESSIVE supranuclear palsy , *VESTIBULAR stimulation , *STOCHASTIC resonance , *PARKINSON'S disease , *SENSORY stimulation , *VESTIBULAR apparatus , *SYMPTOMS - Abstract
Background: Postural imbalance and falls are an early disabling symptom in patients with progressive supranuclear palsy (PSP) of multifactorial origin that may involve abnormal vestibulospinal reflexes. Low-intensity noisy galvanic vestibular stimulation (nGVS) is a non-invasive treatment to normalize deficient vestibular function and attenuate imbalance in Parkinson's disease. The presumed therapeutic mode of nGVS is stochastic resonance (SR), a mechanism by which weak sensory noise stimulation can enhance sensory information processing. Objective: To examine potential treatment effects of nGVS on postural instability in 16 patients with PSP with a clinically probable and [18F]PI-2620 tau-PET-positive PSP. Methods: Effects of nGVS of varying intensity (0–0.7 mA) on body sway were examined, while patients were standing with eyes closed on a posturographic force plate. We assumed a bell-shaped response curve with maximal sway reductions at intermediate nGVS intensities to be indicative of SR. An established SR-curve model was fitted on individual patient outcomes and three experienced human raters had to judge whether responses to nGVS were consistent with the exhibition of SR. Results: We found nGVS-induced reductions of body sway compatible with SR in 9 patients (56%) with optimal improvements of 31 ± 10%. In eight patients (50%), nGVS-induced sway reductions exceeded the minimal clinically important difference (improvement: 34 ± 5%), indicative of strong SR. Conclusion: nGVS yielded clinically relevant reductions in body sway compatible with the exhibition of SR in vestibular sensorimotor pathways in at least half of the assessed patients. Non-invasive vestibular noise stimulation may be thus a well-tolerated treatment strategy to ameliorate postural symptoms in PSP. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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