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5. Bladder Cancer Treatments in the Age of Personalized Medicine: A Comprehensive Review of Potential Radiosensitivity Biomarkers.

Author

Feghaly, Charbel, Challita, Rafka, Hadir, Hanine Bou, Mobayed, Tala, Bitar, Tarek Al, Harbi, Mohammad, Ghorayeb, Hala, El-Hassan, Rana, and Bodgi, Larry

Subjects
DOUBLE-strand DNA breaks, BLADDER cancer, DEATH receptors, DNA repair, CANCER patients
Abstract

Bladder cancer is one of the most frequently diagnosed cancers in men. While cystectomy remains the primary treatment, advances in radiotherapy and chemotherapy have highlighted the value of bladder-preserving strategies, which can also enhance patients' quality of life. Despise these advances, around 20% of patients may still require salvage cystectomy due to tumor radioresistance. This underscores the need to develop radiosensitivity predictive assays. Radiotherapy acts by inducing DNA damage, primarily through DNA double-strand breaks, which can significantly affect treatment outcomes if left unrepaired. In addition to activating DNA repair pathways, the response to radiation also involves the tumor microenvironment, cell death pathways, immune responses and different types of cell death and proliferation receptors. In recent years, personalized medicine, which tailors treatments to individual patients, has gained increasing attention in cancer care. The development of chemo- and radiosensitivity predictive assays has become a key focus of cancer research. Despite the potential impact of such assays on bladder cancer treatment, there is still no reliable test that can help clinicians and informs patients in choosing the best treatment. This review aims to highlight studies that attempted to characterize bladder cancer radiosensitivity and to discuss the potential biomarkers that could be used to develop bladder cancer radiosensitivity predictive assays. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Prediction of Cancer Proneness under Influence of X-rays with Four DNA Mutability and/or Three Cellular Proliferation Assays.

Author

El Nachef, Laura, Bodgi, Larry, Estavoyer, Maxime, Buré, Simon, Jallas, Anne-Catherine, Granzotto, Adeline, Restier-Verlet, Juliette, Sonzogni, Laurène, Al-Choboq, Joëlle, Bourguignon, Michel, Pujo-Menjouet, Laurent, and Foray, Nicolas

Subjects
*TUMOR risk factors, *RISK assessment, *PREDICTIVE tests, *FLOW cytometry, *RESEARCH funding, *CELL proliferation, *DNA, *GENETIC risk score, *FIBROBLASTS, *X-rays, *GENETIC mutation, *BIOLOGICAL assay, *GENETIC techniques
Abstract

Simple Summary: By hypothesizing that molecular hyper-recombination and cellular proliferation are among the major features of multi-factorial cancer proneness, by using skin fibroblasts derived from eight major cancer syndromes, a significant correlation was found between the hyper-recombination rate quantified by plasmid assay, proliferation capacity assessed by flow cytometry, and excess of relative cancer risk (ERR). The product of the hyper-recombination rate and capacity of proliferation described a linear function of ERR. Context: Although carcinogenesis is a multi-factorial process, the mutability and the capacity of cells to proliferate are among the major features of the cells that contribute together to the initiation and promotion steps of cancer formation. Particularly, mutability can be quantified by hyper-recombination rate assessed with specific plasmid assay, hypoxanthine-guanine phosphoribosyltransferase (HPRT) mutations frequency rate, or MRE11 nuclease activities. Cell proliferation can be assessed by flow cytometry by quantifying G2/M, G1 arrests, or global cellular evasion. Methods: All these assays were applied to skin untransformed fibroblasts derived from eight major cancer syndromes characterized by their excess of relative cancer risk (ERR). Results: Significant correlations with ERR were found between hyper-recombination assessed by the plasmid assay and G2/M arrest and described a third-degree polynomial ERR function and a sigmoidal ERR function, respectively. The product of the hyper-recombination rate and capacity of proliferation described a linear ERR function that permits one to better discriminate each cancer syndrome. Conclusions: Hyper-recombination and cell proliferation were found to obey differential equations that better highlight the intrinsic bases of cancer formation. Further investigations to verify their relevance for cancer proneness induced by exogenous agents are in progress. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Impaired DNA Double-Strand Break Repair in Irradiated Sheep Lung Fibroblasts: Late Effects of Previous Irradiation of the Spinal Thecal Sac.

Author

Youssef, Bassem, Feghaly, Charbel, Al Choboq, Joelle, Bou-Gharios, Jolie, Challita, Rafka, Azzi, Joyce, Bou Hadir, Hanine, Abi Antoun, Fabienne, Araji, Tarek, Taddei, Phillip J., Geara, Fady, Sfeir, Pierre, Jurjus, Abdo, Abou-Kheir, Wassim, and Bodgi, Larry

Subjects
BIOPSY, COLONY-forming units assay, RESEARCH funding, DNA, SPINAL tumors, FLUORESCENT antibody technique, FIBROBLASTS, CELL lines, ANIMAL experimentation, SHEEP, DNA repair, CELL nuclei, RADIATION doses, BRAIN tumors, BIOMARKERS
Abstract

Simple Summary: Childhood cancer survivors treated with radiotherapy face the likelihood of long-term complications, including mutations. In order to assess the long-term effect of radiotherapy on the capacity of cells to repair their DNA double-strand breaks (DSBs), five lambs received medulloblastoma radiotherapy to the thecal sac, with three lambs serving as controls. Four years later, lung biopsies were taken and fibroblast cells were amplified and re-irradiated. The cells from the previously treated sheep showed a significant impairment of their DNA DSB repair mechanism, highlighting a potential increase in radiosensitivity. Our results show that previous irradiation can impair the DNA DSB repair mechanism of ovine lung fibroblasts. Children with cancer previously treated with radiotherapy face the likelihood of side effects that can be debilitating or fatal. This study aimed to assess the long-term effect of medulloblastoma radiotherapy on the DNA double-strand break (DSB) repair capability of primary fibroblasts derived from lung biopsies of previously irradiated young sheep. This study included biopsies from three control and five irradiated sheep. The treated sheep had previously received spinal radiotherapy at a total dose of 28 Gy, which is equivalent to pediatric medulloblastoma treatment. Lung biopsies were taken 4 years post-irradiation from high-dose (HD, >18 Gy) and low-dose (LD, <2 Gy) regions. Fifteen cell lines were extracted (six control, four LD and five HD). The cells were irradiated, and DNA DSB repair was analyzed by immunofluorescence. Clonogenic, trypan blue and micronuclei assays were performed. Both the HD and LD cell lines had a significantly higher number of residual γH2AX foci 24 h and a significant decrease in pATM activity post-irradiation compared to the control. There was no statistically significant difference in the clonogenic assay, trypan blue and micronuclei results. Our study showed that a previous irradiation can impair the DNA DSB repair mechanism of ovine lung fibroblasts. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Influence of the Hypersensitivity to Low Dose Phenomenon on the Tumor Response to Hypofractionated Stereotactic Body Radiation Therapy

Author

Le Reun, Eymeric, primary, Granzotto, Adeline, additional, Pêtre, Adeline, additional, Bodgi, Larry, additional, Beldjoudi, Guillaume, additional, Lacornerie, Thomas, additional, Vallet, Véronique, additional, Bouchet, Audrey, additional, Al-Choboq, Joëlle, additional, Bourguignon, Michel, additional, Thariat, Juliette, additional, Bourhis, Jean, additional, Lartigau, Eric, additional, and Foray, Nicolas, additional

Published
2023
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16. Inclusion of Nitrofurantoin into the Realm of Cancer Chemotherapy via Biology-Oriented Synthesis and Drug Repurposing

Author

Elzahhar, Perihan A., primary, Nematalla, Hisham A., additional, Al-Koussa, Houssam, additional, Abrahamian, Carla, additional, El-Yazbi, Amira F., additional, Bodgi, Larry, additional, Bou-Gharios, Jolie, additional, Azzi, Joyce, additional, Al Choboq, Joelle, additional, Labib, Hala F., additional, Kheir, Wassim Abou, additional, Abu-Serie, Marwa M., additional, Elrewiny, Mohamed A., additional, El-Yazbi, Ahmed F., additional, and Belal, Ahmed S. F., additional

Published
2023
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17. Influence of Nucleoshuttling of the ATM Protein in the Healthy Tissues Response to Radiation Therapy: Toward a Molecular Classification of Human Radiosensitivity

Author

Granzotto, Adeline, Benadjaoud, Mohamed Amine, Vogin, Guillaume, Devic, Clément, Ferlazzo, Mélanie L., Bodgi, Larry, Pereira, Sandrine, Sonzogni, Laurène, Forcheron, Fabien, Viau, Muriel, Etaix, Aurélie, Malek, Karim, Mengue-Bindjeme, Laurence, Escoffier, Clémence, Rouvet, Isabelle, Zabot, Marie-Thérèse, Joubert, Aurélie, Vincent, Anne, Venezia, Nicole Dalla, Bourguignon, Michel, Canat, Edme-Philippe, d'Hombres, Anne, Thébaud, Estelle, Orbach, Daniel, Stoppa-Lyonnet, Dominique, Radji, Abderraouf, Doré, Eric, Pointreau, Yoann, Bourgier, Céline, Leblond, Pierre, Defachelles, Anne-Sophie, Lervat, Cyril, Guey, Stéphanie, Feuvret, Loic, Gilsoul, Françoise, Berger, Claire, Moncharmont, Coralie, de Laroche, Guy, Moreau-Claeys, Marie-Virginie, Chavaudra, Nicole, Combemale, Patrick, Biston, Marie-Claude, Malet, Claude, Martel-Lafay, Isabelle, Laude, Cécile, Hau-Desbat, Ngoc-Hanh, Ziouéche, Amira, Tanguy, Ronan, Sunyach, Marie-Pierre, Racadot, Séverine, Pommier, Pascal, Claude, Line, Baleydier, Frédéric, Fleury, Bertrand, de Crevoisier, Renaud, Simon, Jean-Marc, Verrelle, Pierre, Peiffert, Didier, Belkacemi, Yazid, Bourhis, Jean, Lartigau, Eric, Carrie, Christian, De Vathaire, Florent, Eschwege, François, Puisieux, Alain, Lagrange, Jean-Léon, Balosso, Jacques, and Foray, Nicolas

Published
2016
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21. Quantitative Correlations between Radiosensitivity Biomarkers Show That the ATM Protein Kinase Is Strongly Involved in the Radiotoxicities Observed after Radiotherapy

Author

Le Reun, Eymeric, primary, Bodgi, Larry, additional, Granzotto, Adeline, additional, Sonzogni, Laurène, additional, Ferlazzo, Mélanie L., additional, Al-Choboq, Joëlle, additional, El-Nachef, Laura, additional, Restier-Verlet, Juliette, additional, Berthel, Elise, additional, Devic, Clément, additional, Bouchet, Audrey, additional, Bourguignon, Michel, additional, and Foray, Nicolas, additional

Published
2022
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22. Additional file 1 of Influence of cellular models and individual factor in the biological response to head CT scan exams

Author

Devic, Clément, Bodgi, Larry, Sonzogni, Laurène, Pilleul, Frank, Ribot, Hervé, De Charry, Charlotte, Le Moigne, François, Paul, Didier, Carbillet, Fanny, Munier, Mélodie, and Foray, Nicolas

Abstract

Additional file 1: Figure S1. Kinetics of the γH2AX foci in excess in fibroblasts after a single helical head CT scan (a), or a double-helical head CT scan (b) at the indicated post-irradiation times (t0 = non-irradiated). Data result from those shown in Fig. 2 with background subtraction in order to show γH2AX foci in excess effectively due to CT exposure. Error bars indicate SEM. Figure S2. Kinetics of pATM foci in excess in fibroblasts (a) after a single helical head CT scan, (b) or a double-helical head CT scan at the indicated post-irradiation times (t0 = non irradiated). Data result from those shown in Fig. 3 with background subtraction in order to show γH2AX foci in excess effectively due to CT exposure. Error bars indicate SEM. Figure S3. Kinetics of γH2AX foci in excess in astrocytes (a) after a single helical head CT scan, or (b) a double-helical head CT scan at the indicated post-irradiation times (t0 = non-irradiated). Data result from those shown in Fig. 4 with background subtraction in order to show γH2AX foci in excess effectively due to CT exposure. Error bars indicate SEM. Figure S4. Kinetics of the pATM foci in in excess astrocytes (a) after a single helical head CT scan, or (b) a double-helical head CT scan at the indicated post-irradiation times (t0 = non-irradiated). Data result from those shown in Fig. 5 with background subtraction in order to show γH2AX foci in excess effectively due to CT exposure. Error bars indicate SEM. Figure S5. Distribution of the number of γH2AX foci per cell over the 300 nuclei scored for the 200CLB and 85MA cell lines at 1h after a single-helical head CT exposure. Table S1. Statistical results and p-values

Published
2022
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26. Individual Response to Radiation of Individuals with Neurofibromatosis Type I: Role of the ATM Protein and Influence of Statins and Bisphosphonates

Author

Combemale, Patrick, primary, Sonzogni, Laurène, additional, Devic, Clément, additional, Bencokova, Zuzana, additional, Ferlazzo, Mélanie Lydia, additional, Granzotto, Adeline, additional, Burlet, Steven Franck, additional, Pinson, Stéphane, additional, Amini-Adle, Mona, additional, Al-Choboq, Joëlle, additional, Bodgi, Larry, additional, Bourguignon, Michel, additional, Balosso, Jacques, additional, Bachelet, Jean-Thomas, additional, and Foray, Nicolas, additional

Published
2021
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28. DNA Double-Strand Breaks Induced in Human Cells by Twelve Metallic Species: Quantitative Inter-Comparisons and Influence of the ATM Protein

Author

Viau, Muriel, primary, Sonzogni, Laurène, additional, Ferlazzo, Mélanie L., additional, Berthel, Elise, additional, Pereira, Sandrine, additional, Bodgi, Larry, additional, Granzotto, Adeline, additional, Devic, Clément, additional, Fervers, Béatrice, additional, Charlet, Laurent, additional, and Foray, Nicolas, additional

Published
2021
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29. Radiosensitizing Effect of Curcumin on Human Bladder Cancer Cell Lines: Impact on DNA Repair Mechanisms.

Author

Azzi, Joyce, Waked, Anthony, Bou-Gharios, Jolie, Al Choboq, Joelle, Geara, Fady, Bodgi, Larry, and Maalouf, Mira

Subjects
BLADDER tumors, IN vitro studies, WOUND healing, POLYPHENOLS, CURCUMIN, ANTINEOPLASTIC agents, RADIATION, CHEMORADIOTHERAPY, CELL survival, CELL motility, DYNAMICS, CELLULAR signal transduction, RADIATION-sensitizing agents, FLUORESCENT antibody technique, CELL proliferation, CELL lines, DNA repair
Abstract

Chemo-radiotherapy is one of the promising approaches to treat bladder cancer, but its effectiveness is limited to sensitive patients. Polyphenol curcumin has shown anticancer and radiosensitizing potentials, but the mechanism is not fully understood. Here, the In Vitro response of UM-UC5 and UM-UC6 bladder cell lines to curcumin and radiation treatments was evaluated. The effect of curcumin on the DNA double-strand breaks repair system after treatment with ionizing radiation (2 Gy) was determined by immunofluorescence. Cell viability, proliferation, and survival were performed using trypan blue, MTT, clonogenic, and sphere-forming assays. The migratory ability of both cells was assessed by wound healing. We showed that curcumin treatment increased the radiosensitivity by modifying the DNA double-strand breaks repair kinetics of the most radioresistant cells UM-UC6 without affecting the radiosensitive UM-UC5. Moreover, UM-UC6 cell survival and proliferation was significantly decreased after the combination of curcumin with radiation. Bladder cell migration was also inhibited considerably. Curcumin was also shown to reduce the number and the volume of bladder cancer spheres of both cell lines. This study revealed that curcumin was able to radiosensitize resistant bladder cell line without affecting the sensitive one with minimal side effects through enhancing DNA damage signaling and repair pathway. [ABSTRACT FROM AUTHOR]

Published
2022
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30. The pATM Immunofluorescence assay: a high-performance radiosensitivity assay to predict post radiotherapy overreactions

Author

Vogin, Guillaume, Bastogne, Thierry, Bodgi, Larry, Gillet-Daubin, Julien, Canet, Aurélien, Pereira, Sandrine, Foray, Nicolas, Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), UNICANCER, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), CYBERnano [Villers-lès-Nancy], Biology, genetics and statistics (BIGS), Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Élie Cartan de Lorraine (IECL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Automatique de Nancy (CRAN), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Neolys Diagnostics [Lyon], American University of Beirut Medical Center (AUBMC), American University of Beirut [Beyrouth] (AUB), Multi-scale modelling of cell dynamics : application to hematopoiesis (DRACULA), Centre de génétique et de physiologie moléculaire et cellulaire (CGPhiMC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Camille Jordan [Villeurbanne] (ICJ), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Modélisation mathématique, calcul scientifique (MMCS), Institut Camille Jordan [Villeurbanne] (ICJ), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Camille Jordan (ICJ), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), and Institut Camille Jordan (ICJ)

Subjects
[STAT.AP]Statistics [stat]/Applications [stat.AP], [SDV.CAN]Life Sciences [q-bio]/Cancer
Abstract

International audience; Purpose dentifying prior treatment, the patients who will overreact to radiotherapy (RT) would have sound positive clinical implications. By focusing on DNA double-strand breaks (DSB) recognition and repair proteins after irradiation, we recently demonstrated that the maximal number of pATM nuclear foci in the first hour (pATMmax) after ex vivo irradiation correlated with post-RT toxicity severity. We aimed to carry out additional analyses on our whole collection of fibroblast lines to refine the predictive performance of our assay.

Published
2018

32. Fast and binary assay for predicting radiosensitivity based on the nucleoshuttling of ATM protein: development, validation and performances

Author

Pereira, Sandrine, Bodgi, Larry, Duclos, Mirlande, Canet, Aurélien, Ferlazzo, Mélanie L., Devic, Clément, Granzotto, Adeline, Deneuve, Sophie, Vogin, Guillaume, Foray, Nicolas, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Multi-scale modelling of cell dynamics : application to hematopoiesis (DRACULA), Centre de génétique et de physiologie moléculaire et cellulaire (CGPhiMC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Camille Jordan [Villeurbanne] (ICJ), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Modélisation mathématique, calcul scientifique (MMCS), Institut Camille Jordan [Villeurbanne] (ICJ), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Camille Jordan (ICJ), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), and Institut Camille Jordan (ICJ)

Subjects
[STAT.AP]Statistics [stat]/Applications [stat.AP], ATM nucleo-shuttling, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, radiosensivity, tissue reactions, DSB repair
Abstract

International audience; PurposeThe societal and clinical impact of post-radiotherapy adverse tissue events (AE) has highlighted the need of molecular parameters to predict individual radiosensitivity. Recent studies have stressed the role of the phosphorylated forms of the ATM protein (pATM) and its nucleoshuttling in response to radiation. The statistical performance of the pATM immunofluorescence assay to predict AE is promising. However, immunofluorescence requires a time-consuming amplification of cells. The purpose of this study was to develop a predictive assay based on the ELISA technique that renders faster the previous approach.Materials and methodsThis study was performed on 30 skin fibroblasts from 9 radioresistant and 21 AE patients. Patients were divided in 2 groups, radioresistant (toxicity grade

Published
2017

33. In Reply to Azria et al

Author

Pereira, Sandrine, primary, Bodgi, Larry, additional, Duclos, Mirlande, additional, Canet, Aurélien, additional, Ferlazzo, Mélanie L., additional, Devic, Clément, additional, Granzotto, Adeline, additional, Deneuve, Sophie, additional, Vogin, Guillaume, additional, and Foray, Nicolas, additional

Published
2018
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34. Radiobiological Characterization of Tuberous Sclerosis: a Delay in the Nucleo-Shuttling of ATM May Be Responsible for Radiosensitivity

Author

Ferlazzo, Mélanie L., primary, Bach-Tobdji, Mohamed Kheir Eddine, additional, Djerad, Amar, additional, Sonzogni, Laurène, additional, Devic, Clément, additional, Granzotto, Adeline, additional, Bodgi, Larry, additional, Bachelet, Jean-Thomas, additional, Djefal-Kerrar, Assia, additional, Hennequin, Christophe, additional, and Foray, Nicolas, additional

Published
2017
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39. Mutations of the Huntington’s Disease Protein Impact on the ATM-Dependent Signaling and Repair Pathways of the Radiation-Induced DNA Double-Strand Breaks: Corrective Effect of Statins and Bisphosphonates

Author

Ferlazzo, Mélanie L., primary, Sonzogni, Laurène, additional, Granzotto, Adeline, additional, Bodgi, Larry, additional, Lartin, Océane, additional, Devic, Clément, additional, Vogin, Guillaume, additional, Pereira, Sandrine, additional, and Foray, Nicolas, additional

Published
2013
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