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3. Association of Chorioamnionitis with Cerebral Palsy at Two Years after Spontaneous Very Preterm Birth: The EPIPAGE-2 Cohort Study

Author

Arnaud, Catherine, Arthuis, Chloé, Blanc, Julie, Boileau, Pascal, Debillon, Thierry, D’Ercole, Claude, Desplanches, Thomas, Diguisto, Caroline, Garbi, Aurélie, Gascoin, Géraldine, Gire, Catherine, Langer, Bruno, Letouzey, Mathilde, Monier, RM, Isabelle, Morgan, Andrei, Rozé, Jean-Christophe, Schmitz, Thomas, Tosello, Barthélémy, Vayssiére, Christophe, Winer, Norbert, Zeitlin, Jennifer, Maisonneuve, Emeline, Lorthe, Elsa, Torchin, Héloïse, Delorme, Pierre, Devisme, Louise, L’Hélias, Laurence Foix, Marret, Stéphane, Subtil, Damien, Bodeau-Livinec, Florence, Pierrat, Véronique, Sentilhes, Loïc, Goffinet, François, Ancel, Pierre-Yves, and Kayem, Gilles

Published
2020
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4. Is Neurodevelopmental Assessment in Early Childhood Predictive of Performance Assessed Later in Childhood and Adolescence in Sub-Saharan Africa? A Systematic Review of the Literature.

Author

Zoumenou, Roméo, Bodeau-Livinec, Florence, Chausseboeuf, Léa, Boivin, Michael J, and Wendland, Jaqueline

Subjects
*ADOLESCENCE, *COGNITIVE development, *NEURAL development, *ORPHANS, *CHILD development, *COGNITIVE ability, *GRADE repetition
Abstract

Background Most neurodevelopmental tests used to assess child development in sub-Saharan Africa were developed in western or high-income countries, raising the question of their usefulness with African children. Objective This systematic review identified and synthesized key findings from studies measuring development in children in Sub-Saharan Africa in early childhood and again at school age, to assess neurocognitive associations longitudinally from infancy through middle childhood. Methods The study was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses method, selecting articles referenced in the PubMed, PsycInfo, and Embase databases using the following inclusion criteria: published between 2000 and 2022, written in French or English, and presenting results dealing with the objective assessment of child's neurodevelopment. All articles were registered in the Zotero reference manager and analyzed by title, abstract, and full text. Results Several of the seven selected studies confirmed that attention and working memory in infancy can predict children's neurocognitive performance, including mathematical ability, at school age. In two of the studies, children with poor mental development at 1 year of age are more likely to present with poorer behavioral development at school age, including learning difficulties in school and risk for grade repetition. Conclusion Cognitive ability assessed in early childhood is strongly associated with performance at school age in cohorts of African children followed longitudinally. Even with assessments adapted cross-culturally, infants and preschoolers at risk for poor developmental outcomes can be identified to better receive strategic early interventions to enhance their development. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Mapping competency in public health training – experience of the Europubhealth consortium.

Author

Grimaud, Olivier, Foucrier, Mathilde, Czabanowska, Kasia, Barnes, Sarah, Bauernfeind, Ariane, Clemens, Timo, Codd, Mary, Donneau, Anne-Françoise, Sowada, Christoph, Keller, Catherine, Gely-Pernot, Aurore, Mueller, Judith, Guevel, Marie-Renée, Bodeau-Livinec, Florence, and Théault, Laurence

Subjects
CONSORTIA, PUBLIC health education, PUBLIC health, WORLD health, EDUCATIONAL objectives
Abstract

Background: Public health education aims at producing a competent workforce. The WHO-ASPHER framework proposes a set of relevant public health competencies organised in 10 sections (e.g. science practice, leadership, law policies and ethics etc). As part of the Europubhealth (EPH) consortium, eight universities collaborate for the delivery of a 2-year international public health master course. The training pathway includes a first "foundation" year, with a choice of four options (components), and a second "specialisation" year with a choice of seven components. In 2020, EPH consortium decided to use the WHO-ASPHER framework in order to map the competencies addressed and the level of proficiency targeted by each component of its master course. Methods: An 84-item questionnaire covering the whole WHO-ASPHER framework was sent to the 11 EPH component coordinators, asking them to rate the proficiency levels targeted at the end of their courses. Answers from each coordinator were summarised by calculating mean proficiency levels for each of the 10 competency sections. We used Bland & Altman plots to explore heterogeneity of answers and then calculated transformed scores to account for rating heterogeneity. We use tabulation and a heat map to explore patterns of proficiency levels across components. Results: There were differences in overall proficiency levels between years with, as expected, higher scores in year two. Year one components reached medium to high proficiency scores for the sections "science practice", "health promotion" and "communication" with scores ranging from 2.6 to 3 (on a 1-low to 4-high scale). When compared with year one on a heat-map, year two components displayed more contrasted profiles, typically aiming for high proficiency level (i.e. scores above 3.5) on 3 out of the 10 sections of competencies. Except for the "collaborations and partnership" section, the training pathways offered by the EPH master course seem to offer opportunities for a high proficiency level in all domains of competencies. Conclusions: The mapping proved a useful exercise to identify strengths and complementarities among the EPH consortium. The results suggest that the EPH master course is coherent and offers students opportunities to gain proficiency in most competencies relevant to public health practice. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Lead Exposure in Infancy and Subsequent Growth in Beninese Children

Author

Ahmadi, Shukrullah, primary, Botton, Jérémie, additional, Zoumenou, Roméo, additional, Ayotte, Pierre, additional, Fievet, Nadine, additional, Massougbodji, Achille, additional, Alao, Maroufou Jules, additional, Cot, Michel, additional, Glorennec, Philippe, additional, and Bodeau-Livinec, Florence, additional

Published
2022
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11. Lead Exposure in Infancy and Subsequent Childhood Growth

Author

Ahmadi, Shukrullah, primary, Botton, Jérémie, additional, Zoumenou, Roméo, additional, Ayotte, Pierre, additional, Fievet, Nadine, additional, Massougbodji, Achille, additional, Alao, Maroufou Jules, additional, Cot, Michel, additional, Glorennec, Philippe, additional, and Bodeau-Livinec, Florence, additional

Published
2022
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12. Les enfants victimes de la crise sanitaire

Author

Claudet, Isabelle, Duché, Pascale, Aujard, yannick, Villemeur, Agathe Billette De, Bodeau-Livinec, Florence, Com-Ruelle, Laure, Damville, Emmanuelle, Debost, Emmanuel, Marchand-Tonel, Claire, Saurel-Cubizolles, Marie-Josèphe, Lang, Thierry, École des Hautes Études en Santé Publique [EHESP] (EHESP), Département Méthodes quantitatives en santé publique (METIS), Laboratoire Interdisciplinaire Solidarités, Sociétés, Territoires (LISST), and École des hautes études en sciences sociales (EHESS)-Université Toulouse - Jean Jaurès (UT2J)-École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Enfants, Crise sanitaire, Conséquences, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Adolescents
Abstract

International audience; Plan : - Les conséquences directes de la crise : - Des conséquences psychologiques prévisibles ; - Une accidentologie domestique singulière, une explosion de la maltraitance et des violences intrafamiliales ; - Des conséquences physiques d’une routine quotidienne chamboulée ; - Des conséquences indirectes de la crise : - Des inégalités très marquées ; - Un renoncement aux soins et au suivi médical ; - Des adolescents en souffrance ; - Conclusion

Published
2021

13. Leading causes of preterm delivery as risk factors for intraventricular hemorrhage in very preterm infants: results of the EPIPAGE 2 cohort study

Author

Arnaud, Catherine, Baud, Olivier, Bednarek, Nathalie, Claris, Olivier, Flamant, Cyril, Gire, Catherine, Saliba, Elie, Brissaud, Olivier, Charkaluk, Marie Laure, Favrais, Geraldine, Bodeau-Livinec, Florence, Chevallier, Marie, Debillon, Thierry, Pierrat, Veronique, Delorme, Pierre, Kayem, Gilles, Durox, Mélanie, Goffinet, François, Marret, Stephane, and Ancel, Pierre Yves

Published
2017
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14. The Impact of Maternal Depression and Parent–Child Interactions on Risk of Parasitic Infections in Early Childhood: A Prospective Cohort in Benin

Author

Garrison, Amanda, primary, Maselko, Joanna, additional, Saurel-Cubizolles, Marie-Josèphe, additional, Courtin, David, additional, Zoumenou, Roméo, additional, Boivin, Michael J., additional, Massougbodji, Achille, additional, Garcia, André, additional, Alao, Maroufou Jules, additional, Cot, Michel, additional, Maman, Suzanne, additional, and Bodeau-Livinec, Florence, additional

Published
2021
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15. Pre-conception serum ferritin concentrations are associated with metal concentrations in blood during pregnancy: A cohort study in Benin

Author

Davies, Sarah, primary, Briand, Valérie, additional, Accrombessi, Manfred, additional, Fievet, Nadine, additional, Le Bot, Barbara, additional, Durand, Séverine, additional, Agbota, Gino, additional, Yovo, Emmanuel, additional, Vianou, Bertin, additional, Sossou, Darius, additional, Martin-Prevel, Yves, additional, Massougbodji, Achille, additional, Cot, Michel, additional, Glorennec, Philippe, additional, and Bodeau-Livinec, Florence, additional

Published
2021
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16. The effects of malaria in pregnancy on neurocognitive development in children at one and six years of age in Benin: a prospective mother-child cohort

Author

Garrison, Amanda, Boivin, Michael, Fiévet, Nadine, Zoumenou, Roméo, Alao, Jules, Massougbodji, Achille, Cot, Michel, Bodeau-Livinec, Florence, École des Hautes Études en Santé Publique [EHESP] (EHESP), Michigan State University [East Lansing], Michigan State University System, Centre Hospitalier Universitaire de la Mère et de l’Enfant–Lagune de Cotonou, Université d’Abomey-Calavi (UAC), and Département Méthodes quantitatives en santé publique (METIS)

Subjects
Sub-Saharan Africa, Pregnancy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Child development, Neurocognition, Malaria
Abstract

Accepted manuscript; International audience; Background - Malaria in pregnancy (MiP) contributes significantly to infant mortality rates in Sub-Saharan Africa and has consequences on survivors, such as pre-term birth and low birth weight. However, its impact on long-term neurocognitive development in children remains unknown. Methods - Our prospective cohort included pregnant women and their live-born singletons from the Malaria in Pregnancy Preventive Alternative Drugs clinical trial. MiP was assessed using microscopy and real-time quantitative polymerase chain-reactions (qPCR). Neurocognitive development in children was assessed using the Mullen Scales of Early Learning and the Kaufman Assessment Battery for Children 2 nd edition (KABC-II) at one and six years of age, respectively. Results - Of 493 pregnant women, 196 (40%) were infected with malaria at least once; 121 (31%) with placental malaria diagnosed by qPCR. Multiple linear regression beta coefficients showed that impaired gross motor scores were associated with MiP at least once [-2.55 Confidence Interval (CI) (-5.15, 0.05)], placental malaria by qPCR [-4.95 CI (-7.65, -2.24)], and high parasite density at delivery [-1.92 CI (-3.86, 0.02)] after adjustment. Malaria and high parasite density at the 2 nd ANV were associated with lower KABC-II Non-Verbal Index scores at six years [-2.57 CI (-4.86, -0.28)] and [-1.91 CI (-3.51, -0.32)], respectively. Conclusions - This prospective cohort study provides evidence that MiP, particularly late-term, could have important negative consequences on child development at one and six years of age. Mechanisms behind this association must be further investigated and diagnostic methods in low-income countries should be strengthened to provide adequate treatment.

Published
2021

18. Lead exposure in infancy and subsequent growth in childhood

Author

Ahmadi, Shukrullah, primary, Botton, Jérémie, additional, Zoumenou, Roméo, additional, Fiévet, Nadine, additional, Ayotte, Pierre, additional, Massougbodji, Achille, additional, Alao, Jules Maroufou, additional, Cot, Michel, additional, and Bodeau Livinec, Florence, additional

Published
2021
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20. Soil-transmitted helminth infection in pregnancy and long-term child neurocognitive and behavioral development: A prospective mother-child cohort in Benin

Author

Garrison, Amanda, Boivin, Michael, Khoshnood, Babak, Courtin, David, Alao, Jules, Mireku, Michael, Ibikounle, Moudachirou, Massougbodji, Achille, Cot, Michel, Bodeau-Livinec, Florence, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École des Hautes Études en Santé Publique [EHESP] (EHESP), Département Méthodes quantitatives en santé publique (METIS), Michigan State University [East Lansing], Michigan State University System, Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Centre Hospitalier Universitaire de la Mère et de l'Enfant Lagune (CHU-MEL), University of Lincoln, Université d’Abomey-Calavi = University of Abomey Calavi (UAC), Fondation de France (2015 00060746), Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD- R21-HD060524), European and Developing Countries Clinical Trials Partnership (EDCTP- IP.07.31080.002), Bill and Melinda Gates Foundation, EHESP, SCD, Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 261), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Recherche pour le Développement (IRD)-Université de Paris (UP), and Université d’Abomey-Calavi (UAC)

Subjects
Maternal Health, Emotions, RC955-962, Helminthiasis, Child Behavior, Social Sciences, Cohort Studies, C890 Psychology not elsewhere classified, Soil, Families, C810 Applied Psychology, Child Development, Cognition, Medical Conditions, Pregnancy, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Arctic medicine. Tropical medicine, Medicine and Health Sciences, Psychology, Prospective Studies, C820 Developmental Psychology, Child, Children, Immune Response, Cognitive Neurology, Neuropsychological testing, Eukaryota, Obstetrics and Gynecology, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Cognitive impairment, Neurology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, Public aspects of medicine, RA1-1270, B990 Subjects Allied to Medicine not elsewhere classified, Research Article, Adult, Helminth infections, Cognitive Neuroscience, Immunology, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Signs and Symptoms, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, Helminths, Parasitic Diseases, Humans, Animals, Inflammation, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, Organisms, Biology and Life Sciences, Invertebrates, [SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Age Groups, Hookworms, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Pregnancy Complications, Parasitic, People and Places, Women's Health, Cognitive Science, Population Groupings, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Clinical Medicine, Zoology, [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Neuroscience
Abstract

Background An estimated 30% of women in Sub-Saharan Africa suffer from soil-transmitted helminth infection during pregnancy (SHIP), which has been shown to increase risk of pre-term birth, low birth weight, and maternal anemia. A previous study in Benin found that SHIP was associated with impaired cognitive and gross motor development scores in 635 one-year-old children. The objective of the present study was to follow children prospectively to investigate whether the association between SHIP and child neurocognitive and behavioral development persisted at age six. Principal findings Our prospective child cohort included 487 live-born singletons of pregnant women enrolled in the Malaria in Pregnancy Preventive Alternative Drugs clinical trial in Allada, Benin. SHIP was assessed at three antenatal visits (ANVs) through collection and testing of stool samples. Neurocognitive and behavioral development was assessed in six-year-old children by trained investigators using the Kaufman Assessment Battery for Children 2nd edition and the parent-reported Strengths and Difficulties Questionnaire (SDQ). Multiple linear regression models generated coefficients and 95% confidence intervals and potential mediating factors were tested. Prevalence of SHIP was 13% at the 1st ANV, 9% at the 2nd ANV, and 1% at delivery. SHIP was not associated with low neurocognitive scores in children at six years. Higher SDQ internalizing scores, indicating increased emotional impairments in children, were associated with helminth infection at the 2nd ANV/delivery 1.07 (95% CI 0.15, 2.00) and at least once during pregnancy 0.79 (95% CI 0.12, 1.46) in adjusted models. Mediation analysis did not reveal significant indirect effects of several mediators on this association. Conclusions Our study shows that while SHIP is not associated with impaired long-term neurocognitive development, infections may have significant negative impacts on emotional development in six-year-old children. SHIP remains a critical public health issue, and adequate prevention and treatment protocols should be enforced in low- and middle-income countries., Author summary Soil-transmitted helminth infections impact 1.5 billion individuals, primarily in low- and middle- income countries, each year and contribute to malnutrition, anemia, and impaired neurocognitive development in children. However, these infections in pregnancy and their impact on offspring have been less studied. One previous study found associations between soil-transmitted helminth infection during pregnancy and impaired cognitive functioning in offspring one year after birth. The current study aimed to follow these children prospectively until six years in order to confirm whether these associations persisted or not. Infections during pregnancy were no longer associated with cognitive or motor functioning in children; however, infections were associated with impaired behavioral development. Animal-based models have hypothesized maternal inflammation and poor birth outcomes to be the mechanisms behind this relationship; however, our findings did not support these mechanisms. This is one of very few prospective cohort studies in Sub-Saharan Africa to investigate these associations, and more research is needed to corroborate results. Limitations include limited power and the possibility that results are due to chance from multiple statistical tests. Adequate and accessible prevention and treatment efforts in pregnancy and childhood should be provided to populations in low- and middle- income countries at high risk of infection.

Published
2021

23. Comparison of growth models to describe growth from birth to 6 years in a Beninese cohort of children with repeated measurements

Author

Ahmadi, Shukrullah, Bodeau-Livinec, Florence, Zoumenou, Roméo, Garcia, André, Courtin, David, Alao, Jules, Fievet, Nadine, Cot, Michel, Massougbodji, Achille, Botton, Jérémie, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut de Recherche pour le Développement [Cotonou, Bénin] (IRD), Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 261), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Centre Hospitalier Universitaire de la Mère et de l'Enfant Lagune (CHU-MEL), Université d’Abomey-Calavi = University of Abomey Calavi (UAC), Pharmaco-épidémiologie des produits de santé et sécurité sanitaire [Site de Saint Denis] (GIS EPIPHARE - ANSM), Agence nationale de sécurité du médicament et des produits de santé [Saint-Denis] (ANSM), European and Developing Countries Clinical Trials Partnership (EDCTP)IP.2007.31080.002Malaria in Pregnancy ConsortiumInstituto de Salud Carlos IIIPI08/0564Federal Ministry of Education & Research (BMBF)FKZ: da01KA0803Institut de Recherche pour le Developpement (IRD), FranceBill & Melinda Gates FoundationCGIARFrench National Research Agency (ANR)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)R21-HD060524Fondation de France00079816, ANR-10-PRSP-0012,TOLIMMUNPAL(2010), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université de Paris (UP), Université d’Abomey-Calavi (UAC), EHESP, SCD, and PROGRAMME DE RECHERCHE EN SANTE PUBLIQUE - - TOLIMMUNPAL2010 - ANR-10-PRSP-0012 - PRSP - VALID

Subjects
Male, Epidemiology, statistics & research methods, paediatrics, Cohort Studies, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, Pregnancy, Benin, Humans, Prospective Studies, Child, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, public health, Body Weight, Infant, Newborn, Infant, Bayes Theorem, Body Height, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Child, Preschool, Medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female
Abstract

International audience; Objective To select a growth model that best describes individual growth trajectories of children and to present some growth characteristics of this population.Settings Participants were selected from a prospective cohort conducted in three health centres (Allada, Sekou and Attogon) in a semirural region of Benin, sub-Saharan Africa.Participants Children aged 0 to 6 years were recruited in a cohort study with at least two valid height and weight measurements included (n=961).Primary and secondary outcome measures This study compared the goodness-of-fit of three structural growth models (Jenss-Bayley, Reed and a newly adapted version of the Gompertz growth model) on longitudinal weight and height growth data of boys and girls. The goodness-of-fit of the models was assessed using residual distribution over age and compared with the Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC). The best-fitting model allowed estimating mean weight and height growth trajectories, individual growth and growth velocities. Underweight, stunting and wasting were also estimated at age 6 years.Results The three models were able to fit well both weight and height data. The Jenss-Bayley model presented the best fit for weight and height, both in boys and girls. Mean height growth trajectories were identical in shape and direction for boys and girls while the mean weight growth curve of girls fell slightly below the curve of boys after neonatal life. Finally, 35%, 27.7% and 8% of boys; and 34%, 38.4% and 4% of girls were estimated to be underweight, wasted and stunted at age 6 years, respectively.Conclusion The growth parameters of the best-fitting Jenss-Bayley model can be used to describe growth trajectories and study their determinants.

Published
2020

24. Recent trends in visual impairment and blindness in the UK

Author

Bodeau-Livinec, Florence, Surman, Geraldine, Kaminski, Monique, Wilkinson, Andrew R., Ancel, Pierre-Yves, and Kurinczuk, Jennifer J.

Subjects
Vision disorders in children -- Forecasts and trends, Vision disorders in children -- Risk factors, Vision disorders in children -- Demographic aspects, Birth weight, Low -- Health aspects, Infants (Premature) -- Health aspects, Market trend/market analysis
Published
2007

26. Effects of Malaria in Pregnancy on Neurocognitive Development in Children at 1 and 6 Years of Age in Benin: A Prospective Mother–Child Cohort.

Author

Garrison, Amanda, Boivin, Michael J, Fiévet, Nadine, Zoumenou, Roméo, Alao, Jules M, Massougbodji, Achille, Cot, Michel, and Bodeau-Livinec, Florence

Subjects
CHILD development deviations -- Risk factors, MOTHERS, REVERSE transcriptase polymerase chain reaction, CLINICAL trials, CONFIDENCE intervals, CHILD development, MICROSCOPY, MULTIPLE regression analysis, MALARIA, RISK assessment, POLYMERASE chain reaction, LONGITUDINAL method, DISEASE complications, PREGNANCY
Abstract

Background Malaria in pregnancy (MiP) contributes significantly to infant mortality rates in sub-Saharan Africa and has consequences on survivors, such as preterm birth and low birth weight. However, its impact on long-term neurocognitive development in children remains unknown. Methods Our prospective cohort included pregnant women and their live-born singletons from the Malaria in Pregnancy Preventive Alternative Drugs clinical trial. MiP was assessed using microscopy and real-time quantitative polymerase chain reaction (qPCR). Neurocognitive development in children was assessed using the Mullen Scales of Early Learning and the Kaufman Assessment Battery for Children, 2nd edition (KABC-II), at 1 and 6 years of age, respectively. Results Of 493 pregnant women, 196 (40%) were infected with malaria at least once: 121 (31%) with placental malaria diagnosed by qPCR. Multiple linear regression B-coefficients showed that impaired gross motor scores were associated with MiP at least once (−2.55; confidence interval [95% CI]: −5.15, 0.05), placental malaria by qPCR (−4.95; 95% CI: −7.65, −2.24), and high parasite density at delivery (−1.92; 95% CI: −3.86, 0.02) after adjustment. Malaria and high parasite density at the second antenatal care visit were associated with lower KABC-II Non-Verbal Index scores at 6 years (−2.57 [95% CI: −4.86, −0.28] and −1.91 [−3.51, −0.32]), respectively. Conclusions This prospective cohort study provides evidence that MiP, particularly late term, could have important negative consequences on child development at 1 and 6 years of age. Mechanisms behind this association must be further investigated and diagnostic methods in low-income countries should be strengthened to provide adequate treatment. Clinical Trials Registration NCT00811421. [ABSTRACT FROM AUTHOR]

Published
2022
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27. Association of Chorioamnionitis with Cerebral Palsy at Two Years after Spontaneous Very Preterm Birth: The EPIPAGE-2 Cohort Study

Author

Maisonneuve, Emeline, primary, Lorthe, Elsa, additional, Torchin, Héloïse, additional, Delorme, Pierre, additional, Devisme, Louise, additional, L’Hélias, Laurence Foix, additional, Marret, Stéphane, additional, Subtil, Damien, additional, Bodeau-Livinec, Florence, additional, Pierrat, Véronique, additional, Sentilhes, Loïc, additional, Goffinet, François, additional, Ancel, Pierre-Yves, additional, Kayem, Gilles, additional, Arnaud, Catherine, additional, Arthuis, Chloé, additional, Blanc, Julie, additional, Boileau, Pascal, additional, Debillon, Thierry, additional, D’Ercole, Claude, additional, Desplanches, Thomas, additional, Diguisto, Caroline, additional, Garbi, Aurélie, additional, Gascoin, Géraldine, additional, Gire, Catherine, additional, Langer, Bruno, additional, Letouzey, Mathilde, additional, Monier, RM, Isabelle, additional, Morgan, Andrei, additional, Rozé, Jean-Christophe, additional, Schmitz, Thomas, additional, Tosello, Barthélémy, additional, Vayssiére, Christophe, additional, Winer, Norbert, additional, and Zeitlin, Jennifer, additional

Published
2020
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29. Malaria and gravidity interact to modify maternal haemoglobin concentrations during pregnancy

Author

Ouédraogo Smaïla, Bodeau-Livinec Florence, Briand Valérie, Huynh Bich-Tram, Koura Ghislain K, Accrombessi Manfred MK, Fievet Nadine, Massougbodji Achille, Deloron Philippe, and Cot Michel

Subjects
Anaemia, Gravidity, Malaria, Iron deficiency, Prevention, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Primigravidity is one of the main risk factors for both malaria and anaemia. Since the implementation of intermittent preventive treatment (IPTp) in sub-Saharan Africa, the relationship between anaemia and gravidity and its evolution during pregnancy has been little explored. This study aimed to evaluate the impact of gravidity on the variation of haemoglobin during pregnancy according to the timing of gestation. Methods Data from three studies carried out in nearby areas in south Benin (Ouidah, Comé, Allada) between 2005 and 2012 were analysed. At inclusion (first antenatal visit, ANV1) women’s age, area of residence, schooling, gravidity, gestational age, weight and height were recorded. Thick blood smears were performed on ANV1, second visit (ANV2) and at delivery. In Allada, women’s serum ferritin and CRP concentrations were also assessed. The impact of gravidity on maternal haemoglobin (Hb) was analysed using a logistic or linear regression depending on the outcome. The statistical significance was set to P < 0.05. Results In total, data from 3,591 pregnant women were analysed. Both univariate and multivariate analyses showed a constant association between Hb concentrations and gravidity in the three periods of Hb assessment (ANV1, ANV2 and delivery). Mean Hb concentration was significantly lower in primigravidae than in multigravidae at ANV1 (mean difference = -2.4 g/L, CI 95%: [-3.4, -1.4], P < 0.001). Afterwards, there was a significant increase in primigravidae only, with a tendency to reversal between primigravidae and multigravidae, which was confirmed at delivery (mean difference = 2.8 g/L, CI 95%: [1.3, 4.2], P < 0.001). The prevalence of malaria infection was halved between ANV1 and delivery in primigravidae while it decreased by only 38% among multigravidae, who were less prone to malaria infection (prevalence at ANV1, 20% and 10% respectively). Iron deficiency was more common in multigravidae, and it decreased slightly in this group between ANV1 and delivery. Conclusion In a context of IPTp, Hb levels improved progressively throughout pregnancy in primigravidae, likely as a result of reduction in malaria infection. In multigravidae, the improvement was less perceptible and anaemia was mainly due to iron deficiency.

Published
2012
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32. Specialist health care services use in a European cohort of infants born very preterm.

Author

Seppänen, Anna‐Veera, Bodeau‐Livinec, Florence, Boyle, Elaine M, Edstedt‐Bonamy, Anna‐Karin, Cuttini, Marina, Toome, Liis, Maier, Rolf F, Cloet, Eva, Koopman‐Esseboom, Corine, Pedersen, Pernille, Gadzinowski, Janusz, Barros, Henrique, Zeitlin, Jennifer, Seppänen, Anna-Veera, Bodeau-Livinec, Florence, Edstedt-Bonamy, Anna-Karin, Koopman-Esseboom, Corine, and Effective Perinatal Intensive Care in Europe (EPICE) research group

Subjects
*MEDICAL care use, *MEDICAL care, *HEALTH information services, *INFANTS, *PREMATURE labor, *BIRTH size, *LOW birth weight, *COMPARATIVE studies, *LONGITUDINAL method, *MEDICAL cooperation, *MEDICAL specialties & specialists, *RESEARCH, *SOCIOECONOMIC factors, *EVALUATION research, *PATIENTS' attitudes
Abstract

Aim: Children born very preterm require additional specialist care because of the health and developmental risks associated with preterm birth, but information on their health service use is sparse. We sought to describe the use of specialist services by children born very preterm in Europe.Method: We analysed data from the multi-regional, population-based Effective Perinatal Intensive Care in Europe (EPICE) cohort of births before 32 weeks' gestation in 11 European countries. Perinatal data were abstracted from medical records and parents completed a questionnaire at 2 years corrected age (4322 children; 2026 females, 2296 males; median gestational age 29wks, interquartile range [IQR] 27-31wks; median birthweight 1230g, IQR 970-1511g). We compared parent-reported use of specialist services by country, perinatal risk (based on gestational age, small for gestational age, and neonatal morbidities), maternal education, and birthplace.Results: Seventy-six per cent of the children had consulted at least one specialist, ranging across countries from 53.7% to 100%. Ophthalmologists (53.4%) and physiotherapists (48.0%) were most frequently consulted, but individual specialists varied greatly by country. Perinatal risk was associated with specialist use, but the gradient differed across countries. Children with more educated mothers had higher proportions of specialist use in three countries.Interpretation: Large variations in the use of specialist services across Europe were not explained by perinatal risk and raise questions about the strengths and limits of existing models of care.What This Paper Adds: Use of specialist services by children born very preterm varied across Europe. This variation was observed for types and number of specialists consulted. Perinatal risk was associated with specialist care, but did not explain country-level differences. In some countries, mothers' educational level affected use of specialist services. [ABSTRACT FROM AUTHOR]

Published
2019
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34. Bereavement-related depression: Did the changes induced by DSM-V make a difference? Results from a large population-based survey of French residents

Author

Bodeau-Livinec Florence, Husky Mathilde, Kovess-Masfety Viviane, Clesse Florence, Leray Emmanuelle, École des Hautes Études en Santé Publique [EHESP] (EHESP), Département Méthodes quantitatives en santé publique (METIS), Recherche en Pharmaco-épidémiologie et Recours aux Soins (REPERES), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP), Direction Générale de l׳Offre de Soins, Direction Générale des Services, and Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)

Subjects
Adult, Male, medicine.medical_specialty, Healthcare use, Diagnostic criteria, Adolescent, Major depressive episode, Large population, Service use, behavioral disciplines and activities, Young Adult, 03 medical and health sciences, 0302 clinical medicine, mental disorders, Prevalence, Humans, Medicine, 030212 general & internal medicine, Medical prescription, Psychiatry, Depression (differential diagnoses), Aged, Aged, 80 and over, Depressive Disorder, Major, Psychotropic Drugs, business.industry, Middle Aged, Clinical judgment, Health Surveys, DSM-V, 030227 psychiatry, 3. Good health, Causality, Diagnostic and Statistical Manual of Mental Disorders, Psychiatry and Mental health, Clinical Psychology, Cross-Sectional Studies, Psychotropic drug, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, medicine.symptom, business, Bereavement, Clinical psychology
Abstract

International audience; Background: DSM-V has been criticized for excessively expanding criteria for bereavement-related depression. The aim of this study was to quantify a potential increase in depression prevalence due to changes in diagnostic criteria and to assess the severity, clinical profile and healthcare use of new cases.Methods: A cross-sectional telephone survey was performed in 2005-2006 in four French regions. Twelve-month prevalence of psychiatric disorders was measured by CIDI-SF. Bereavement was assessed in those who endorsed the gate question to the depression module. Persons with bereavement-related depression according to DSM-IV and DSM-V diagnosis criteria were compared.Results: Of the 22,138 respondents, 692 were bereaved. The prevalence of depression among those bereaved was 49.9% (95% CI ¼=43.7−56.0) according to DSM-IV and 59.6% (53.1−66.1) according to DSM-V [corrected]. The overall prevalence of major depression increased from 8.6% (8.1–9.1) with DSM-IV to 8.8% (8.3−9.3) with DSM-V . Cases diagnosed using DSM-IV presented more symptoms than cases diagnosed using DSM-V but clinical features were similar except regarding criterion E׳s symptoms. Healthcare use was similar between the two groups regarding consultations and psychotropic drug prescription.Limitations: Some DSM-IV and DSM-V criteria were difficult to operationalize in the survey. The observed difference in prevalence according to DSM-IV and DSM-V may be reduced when clinical judgment is taken into account.Conclusions: The overall prevalence of major depression is only marginally increased by the new criteria. However, diagnostic changes increase the prevalence by 10 points among those bereaved. Diagnostic changes do not appear to modify service use.

Published
2015

35. Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks’ gestation in France in 2011: EPIPAGE-2 cohort study

Author

Pierrat, Véronique, Marchand-Martin, Laetitia, Arnaud, Catherine, Kaminski, Monique, Resche-Rigon, Matthieu, Lebeaux, Cécile, Bodeau-Livinec, Florence, Morgan, Andrei S., Goffinet, François, Marret, Stéphane, Ancel, Pierre-Yves, Rozé, Jean-Christophe, Flamant, Cyril, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Centre Hospitalier Universitaire de Lille (CHU de Lille), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de l'information médicale et de la biostatistique [AP-HP Hôpital Saint-Louis], AP-HP Hôpital Saint-Louis, Département Méthodes quantitatives en santé publique (METIS), École des Hautes Études en Santé Publique [EHESP] (EHESP), DHU Risques Et Grossesse, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Service de pédiatrie néonatale et réanimation - neuropédiatrie [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), CIC - Mère Enfant Necker Cochin Paris Centre (CIC 1419), CHU Cochin [AP-HP]-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), This project has been funded with support from the following organisations: The French Institute of Public Health Research/Institute of Public Health and its partners: the French Health Ministry, the National Institute of Health and Medical Research (INSERM), the National Institute of Cancer, and the National Solidarity Fund for Autonomy (CNSA), The National Research Agency through the French EQUIPEX program of investments in the future (reference ANR-11-EQPX-0038), the PREMUP Foundation, Fondation de France (reference 00050329), and Fondation pour la Recherche Médicale (reference SPF20160936356)., ANR-11-EQPX-0038/11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de pédiatrie néonatale et réanimation - neuropédiatrie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), pierrat, veronique, Equipements d'excellence - Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance - - RE-CO-NAI2011 - ANR-11-EQPX-0038 - EQPX - VALID, Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique ( CRESS - U1153 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité ( CRESS (U1153 / UMR_A 1125) ), Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Universitaire de Lille ( CHU de Lille ), Épidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps, Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Département Méthodes quantitatives en santé publique ( METIS ), École des Hautes Études en Santé Publique [EHESP] ( EHESP ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Assistance publique - Hôpitaux de Paris (AP-HP), CHU Rouen-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Hôpital Charles Nicolle [Rouen], Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques ( GPMCND ), Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institute for Research and Innovation in Biomedicine ( IRIB ), CIC - Mère Enfant Necker Cochin Paris Centre ( CIC 1419 ), CHU Cochin [AP-HP]-Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), ANR-11-EQPX-0038/11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance ( 2011 ), CHU Lille, Université de Lille, Hôpital Jeanne de Flandre [Lille], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)], Université Toulouse III - Paul Sabatier [UT3], and Hôpital Saint-Louis

Subjects
Male, Pediatrics, Developmental Disabilities, [ SDV.MHEP.PED ] Life Sciences [q-bio]/Human health and pathology/Pediatrics, Infant, Premature, Diseases, Blindness, Population based cohort, Corrected Age, 0302 clinical medicine, 030202 anesthesiology, Outcome Assessment, Health Care, MESH: Blindness/epidemiology, Blindness/etiology, Cerebral Palsy/epidemiology, Cerebral Palsy/etiology, Child, Preschool, Developmental Disabilities/epidemiology, Developmental Disabilities/etiology, Female, Follow-Up Studies, France/epidemiology, Gestational Age, Hearing Loss/epidemiology, Hearing Loss/etiology, Humans, Infant, Extremely Premature, Infant, Premature, Diseases/epidemiology, Infant, Premature, Diseases/mortality, Infant, Premature, Diseases/physiopathology, Outcome Assessment (Health Care), Prospective Studies, Survivors, 030212 general & internal medicine, Prospective cohort study, education.field_of_study, 030219 obstetrics & reproductive medicine, Gestational age, Gross Motor Function Classification System, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, General Medicine, 3. Good health, Gestation, France, Cohort study, medicine.medical_specialty, Pédiatrie, Population, Cerebral palsy, 03 medical and health sciences, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, 030225 pediatrics, medicine, education, Hearing Loss, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, business.industry, Cerebral Palsy, Research, medicine.disease, Confidence interval, MESH : Blindness/epidemiology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract

International audience; Objectives To describe neurodevelopmental outcomes at 2 years corrected age for children born alive at 22-26, 27-31, and 32-34 weeks' gestation in 2011, and to evaluate changes since 1997.Design Population based cohort studies, EPIPAGE and EPIPAGE-2.Setting France.Participants 5567 neonates born alive in 2011 at 22-34 completed weeks' gestation, with 4199 survivors at 2 years corrected age included in follow-up. Comparison of outcomes reported for 3334 (1997) and 2418 (2011) neonates born alive in the nine regions participating in both studies.Main outcome measures Survival; cerebral palsy (2000 European consensus definition); scores below threshold on the neurodevelopmental Ages and Stages Questionnaire (ASQ; at least one of five domains below threshold) if completed between 22 and 26 months corrected age, in children without cerebral palsy, blindness, or deafness; and survival without severe or moderate neuromotor or sensory disabilities (cerebral palsy with Gross Motor Function Classification System levels 2-5, unilateral or bilateral blindness or deafness). Results are given as percentage of outcome measures with 95% confidence intervals.Results Among 5170 liveborn neonates with parental consent, survival at 2 years corrected age was 51.7% (95% confidence interval 48.6% to 54.7%) at 22-26 weeks' gestation, 93.1% (92.1% to 94.0%) at 27-31 weeks' gestation, and 98.6% (97.8% to 99.2%) at 32-34 weeks' gestation. Only one infant born at 22-23 weeks survived. Data on cerebral palsy were available for 3599 infants (81.0% of the eligible population). The overall rate of cerebral palsy at 24-26, 27-31, and 32-34 weeks' gestation was 6.9% (4.7% to 9.6%), 4.3% (3.5% to 5.2%), and 1.0% (0.5% to 1.9%), respectively. Responses to the ASQ were analysed for 2506 children (56.4% of the eligible population). The proportion of children with an ASQ result below threshold at 24-26, 27-31, and 32-34 weeks' gestation were 50.2% (44.5% to 55.8%), 40.7% (38.3% to 43.2%), and 36.2% (32.4% to 40.1%), respectively. Survival without severe or moderate neuromotor or sensory disabilities among live births increased between 1997 and 2011, from 45.5% (39.2% to 51.8%) to 62.3% (57.1% to 67.5%) at 25-26 weeks' gestation, but no change was observed at 22-24 weeks' gestation. At 32-34 weeks' gestation, there was a non-statistically significant increase in survival without severe or moderate neuromotor or sensory disabilities (P=0.61), but the proportion of survivors with cerebral palsy declined (P=0.01).Conclusions In this large cohort of preterm infants, rates of survival and survival without severe or moderate neuromotor or sensory disabilities have increased during the past two decades, but these children remain at high risk of developmental delay.

Published
2017

38. Cohort profile: effect of malaria in early pregnancy on fetal growth in Benin (RECIPAL preconceptional cohort)

Author

Accrombessi, Manfred, primary, Yovo, Emmanuel, additional, Cottrell, Gilles, additional, Agbota, Gino, additional, Gartner, Agnès, additional, Martin-Prevel, Yves, additional, Fanou-Fogny, Nadia, additional, Djossinou, Diane, additional, Zeitlin, Jennifer, additional, Tuikue-Ndam, Nicaise, additional, Bodeau-Livinec, Florence, additional, Houzé, Sandrine, additional, Jackson, Nicola, additional, Ayemonna, Paul, additional, Massougbodji, Achille, additional, Cot, Michel, additional, Fievet, Nadine, additional, and Briand, Valérie, additional

Published
2018
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39. Leading causes of preterm delivery as risk factors for intraventricular hemorrhage in very preterm infants: results of the EPIPAGE 2 cohort study

Author

Chevallier, Marie, primary, Debillon, Thierry, additional, Pierrat, Veronique, additional, Delorme, Pierre, additional, Kayem, Gilles, additional, Durox, Mélanie, additional, Goffinet, François, additional, Marret, Stephane, additional, Ancel, Pierre Yves, additional, Arnaud, Catherine, additional, Baud, Olivier, additional, Bednarek, Nathalie, additional, Claris, Olivier, additional, Flamant, Cyril, additional, Gire, Catherine, additional, Saliba, Elie, additional, Brissaud, Olivier, additional, Charkaluk, Marie Laure, additional, Favrais, Geraldine, additional, and Bodeau-Livinec, Florence, additional

Published
2017
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42. Country-level and individual correlates of overweight and obesity among primary school children: a cross-sectional study in seven European countries

Author

Mireku, Michael, Boivin, Michael, Davidson, Leslie, Ouédraogo, Smaïla, Koura, Ghislain, Alao, Maroufou, Massougbodji, Achille, Cot, Michel, Bodeau-Livinec, Florence, Olaya, Beatriz, Moneta, Maria Victoria, Pez, Ondine, Bitfoi, Adina, Carta, Mauro Giovanni, Eke, Ceyda, Goelitz, Dietmar, Keyes, Katherine, Kuijpers, Rowella, Lesinskiene, Sigita, Mihova, Zlatka, Otten, Roy, Fermanian, Christophe, Haro, Josep Maria, Kovess, Viviane, Centre Hospitalier Universitaire Yalgado Ouédraogo (CHUYO), parasitology and mycology education, Science and health faculty, Santé de la mère et de l'enfant en milieu tropical : épidémiologie génétique et périnatale, Université Paris Descartes - Paris 5 (UPD5), École des Hautes Études en Santé Publique [EHESP] (EHESP), Unité de recherche clinique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Ambroise Paré, and Universitat de Barcelona

Subjects
Male, Gerontology, Pediatric Obesity, Epidemiology, Cross-sectional study, Overweight, Body Mass Index, Lietuva (Lithuania), Primary school children, Risk Factors, School children, Prevalence, Turkija (Turkey), Parent-Child Relations, Vokietija (Germany), Child, Children, Public health, Schools, Only child, Europe, Italija (Italy), Obesitat, Female, Correlation (Statistics), Rumunija (Romania), medicine.symptom, Europa, Infants, Research Article, Individual and population-level correlates, medicine.medical_specialty, Eastern and Western Europe, Sveikata / Health, Food Preferences, Obesity, medicine, Humans, Nyderlandai (Netherlands), Epidemiologia, Exercise, Life Style, business.industry, Statistics--Medical, Body Weight, Public Health, Environmental and Occupational Health, medicine.disease, Vaikai / Children, Cross-Sectional Studies, Logistic Models, Obesity in children, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Bulgarija (Bulgaria), Biostatistics, business, Body mass index, Demography
Abstract

Background: The present study aims to estimate childhood overweight and obesity prevalence and their association with individual and population-level correlates in Eastern and Western European countries. Methods: Data were obtained from the School Children Mental Health in Europe, a cross-sectional survey conducted in 2010 in Italy, Germany, the Netherlands, Romania, Bulgaria, Lithuania and Turkey. The sample consists of 5,206 school children aged 6 to 11 years old. Information on socio-demographics, children’s height and weight, life-style and parental attitude were reported by the mothers. Country-level indicators were obtained through several data banks. Overweight and obesity in children were calculated according to the international age and gender-specific child Body Mass Index cut-off points. Multivariable logistic regression models included socio-demographic, lifestyle, mothers’ attitude, and country-level indicators to examine the correlates of overweight. Results: Overall prevalence was 15.6% (95% CI = 19.3-21.7%) for overweight and 4.9% (95% CI = 4.3-5.6%) for obesity. In overweight (including obesity), Romanian children had the highest prevalence (31.4%, 95% CI = 28.1-34.6%) and Italian the lowest (10.4%, 95% CI = 8.1-12.6%). Models in the pooled sample showed that being younger (aOR = 0.93, 95% = CI 0.87-0.97), male (aOR = 1.24, 95% CI = 1.07-1.43), an only child (aOR = 1.40, 95% CI = 1.07-1.84), spending more hours per week watching TV (aOR = 1.01, 95% CI =1.002-1.03), and living in an Eastern Country were associated with greater risk of childhood overweight (including obesity). The same predictors were significantly associated with childhood overweight in the model conducted in the Eastern region, but not in the West. Higher Gross Domestic Product and Real Domestic Product, greater number of motor and passenger vehicles, higher percentage of energy available from fat, and more public sector expenditure on health were also associated with lower risk for childhood overweight after adjusting for covariables in the pooled sample and in the east of Europe, but not in the West. Conclusions: Prevalence rates of overweight and obesity in school children is still high, especially in Eastern regions, with some socio-demographic factors and life-styles associated with being overweight. It is also in the Eastern region itself where better macro-economic indicators are related with lower rates of childhood overweight. This represents a public health concern that deserves special attention in those countries undertaking economic and political transitions. Keywords: Overweight, Obesity, School children, Eastern and Western Europe, Individual and population-level correlates.

Published
2015
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