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697 results on '"Boda D"'

1. Simulation study of a rectifying bipolar ion channel: Detailed model versus reduced model

Author

Ható, Z., Boda, D., Gillespie, D., Vrabec, J., Rutkai, G., and Kristóf, T.

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

We study a rectifying mutant of the OmpF porin ion channel using both all-atom and reduced models. The mutant was created by Miedema et al. [Nano Lett., 2007, 7, 2886] on the basis of the N-P semiconductor diode, in which an N-P junction is formed. The mutant contains a pore region with positive amino acids on the left-hand side and negative amino acids on the right-hand side. Experiments show that this mutant rectifies. Although we do not know the structure of this mutant, we can build an all-atom model for it on the basis of the structure of the wild type channel. Interestingly, molecular dynamics simulations for this all-atom model do not produce rectification. A reduced model that contains only the important degrees of freedom (the positive and negative amino acids and free ions in an implicit solvent), on the other hand, exhibits rectification. Our calculations for the reduced model (using the Nernst-Planck equation coupled to Local Equilibrium Monte Carlo simulations) reveal a rectification mechanism that is different from that seen for semiconductor diodes. The basic reason is that the ions are different in nature from electrons and holes (they do not recombine). We provide explanations for the failure of the all-atom model including the effect of all the other atoms in the system as a noise that inhibits the response of ions (that would be necessary for rectification) to the polarizing external field., Comment: 16 pages, 10 figures

Published
2016
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2. Energetics of ion competition in the DEKA selectivity filter of neuronal sodium channels

Author

Boda, D., Leaf, G., Fonseca, J., and Eisenberg, B.

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

The energetics of ionic selectivity in the neuronal sodium channels is studied. A simple model constructed for the selectivity filter of the channel is used. The selectivity filter of this channel type contains aspartate (D), glutamate (E), lysine (K), and alanine (A) residues (the DEKA locus). We use Grand Canonical Monte Carlo simulations to compute equilibrium binding selectivity in the selectivity filter and to obtain various terms of the excess chemical potential from a particle insertion procedure based on Widom's method. We show that K$^{+}$ ions in competition with Na$^{+}$ are efficiently excluded from the selectivity filter due to entropic hard sphere exclusion. The dielectric constant of protein has no effect on this selectivity. Ca$^{2+}$ ions, on the other hand, are excluded from the filter due to a free energetic penalty which is enhanced by the low dielectric constant of protein., Comment: 14 pages, 7 figures

Published
2015
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3. Selective adsorption of ions in charged slit-systems

Author

Valiskó, M., Henderson, D., and Boda, D.

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

We study the selective adsorption of various cations into a layered slit system using grand canonical Monte Carlo simulations. The slit system is formed by a series of negatively charged membranes. The electrolyte contains two kinds of cations with different sizes and valences modelled by charged hard spheres immersed in a continuum dielectric solvent. We present the results for various cases depending on the combinations of the properties of the competing cations. We concentrate on the case when the divalent cations are larger than the monovalent cations. In this case, size and charge have counterbalancing effects, which results in interesting selectivity phenomena., Comment: 12 pages, 6 figures

Published
2013
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4. The origin of interparticle potential of electrorheological fluids

Author

Boda, D., Valiskó, M., and Szalai, I.

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

The particles of electrorheological fluids can be modelled as dielectric spheres (DS) immersed in a continuum dielectric. When an external field is applied, polarization charges are induced on the surfaces of the spheres and can be represented as point dipoles placed in the centres of the spheres. When the DSs are close to each other, the induced charge distributions are distorted by the electric field of the neighbouring DSs. This is the origin of the interaction potential between the DSs. The calculation of this energy is very time consuming, therefore, the DS model cannot be used in molecular simulations. In this paper, we show that the interaction between the point dipoles appropriately approximates the interaction of DSs. The polarizable point dipole model provides better results, but this model is not pair-wise additive, so it is not that practical in particle simulations., Comment: 10 pages, 5 figures

Published
2013
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5. Monte Carlo simulation of the electrical properties of electrolytes adsorbed in charged slit-systems

Author

Kovács, R., Valiskó, M., and Boda, D.

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

We study the adsorption of primitive model electrolytes into a layered slit system using grand canonical Monte Carlo simulations. The slit system contains a series of charged membranes. The ions are forbidden from the membranes, while they are allowed to be adsorbed into the slits between the membranes. We focus on the electrical properties of the slit system. We show concentration, charge, electric field, and electrical potential profiles. We show that the potential difference between the slit system and the bulk phase is mainly due to the double layers formed at the boundaries of the slit system, but polarization of external slits also contributes to the potential drop. We demonstrate that the electrical work necessary to bring an ion into the slit system can be studied only if we simulate the slit together with the bulk phases in one single simulation cell., Comment: 11 pages, 8 figures

Published
2012
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19. Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues (Review)

Author

Boda, D. Docea, A.O. Calina, D. Ilie, M.A. Caruntu, C. Zurac, S. Neagu, M. Constantin, C. Branisteanu, D.E. Voiculescu, V. Mamoulakis, C. Tzanakakis, G. Spandidos, D.A. Drakoulis, N. Tsatsakis, A.M.

Abstract

Human papilloma viruses (HPV) are a small group of non-enveloped viruses belonging to the Papillomaviridae family with strong similarities to polyoma viruses. The viral particles consist of a genome in the form of a circular double-stranded DNA, encompassing eight open reading frames, as well as a non-enveloped icosahedral capsid. HPV infection is considered the most common sexually transmitted disease in both sexes and is strongly implicated in the pathogenesis of different types of cancer. 'High-risk' mucosal HPV types, predominantly types 16, 18, 31, 33 and 35, are associated with most cervical, penile, vulvar, vaginal, anal, oropharyngeal cancers and pre-cancers. Screening for HPV is necessary for the prognosis and for determining treatment strategies for cancer. Novel HPV markers, including proteomic and genomic markers, as well as anti-papillomavirus vaccines are currently available. The aim of this comprehensive review was to thoroughly present the updated information on virus development, cancer occurrence, treatment and prevention strategies, in an attempt to shed further light into the field, including novel research avenues.

Published
2018

20. Symposium über Anforderungen an diätetische Lebensmittel zur Behandlung von angeborenen Aminosäurestoffwechselstörungen, insbesondere Phenylketonurie

Author

Bachmann, K. D., Berger, H., Bierich, J., Boda, D., Bremer, H.-J., Brodehl, J., Burgio, G. R., Fischer, K., Gladtke, E., Hadorn, B., Hagberg, B., Hallman, N., Hansen, H. G., Harbauer, H., von Harnack, G.-A., Hecker, W. C., Helge, H., Hitzig, W. H., Huth, E., Kleihauer, E., Künzer, W., Lassrich, M. A., Leiber, B., Lindquist, B., Marget, W., Oehme, J., Olbing, H., Pfeiffer, R. A., Prader, A., Riegel, K., Rossi, E., Schärer, K., Schmidt, E., Schulte, F.-J., Spiess, H., Spranger, J., Stalder, G., Stephan, U., Stoermer, J., Ströder, J., Teller, W., Zetterström, R., Zweymüller, E., Bachmann, K. D., editor, Berger, H., editor, Bierich, J., editor, Boda, D., editor, Bremer, H.-J., editor, Brodehl, J., editor, Burgio, G. R., editor, Fischer, K., editor, Gladtke, E., editor, Hadorn, B., editor, Hagberg, B., editor, Hallman, N., editor, Hansen, H. G., editor, Harbauer, H., editor, von Harnack, G.-A., editor, Hecker, W. C., editor, Helge, H., editor, Hitzig, W. H., editor, Huth, E., editor, Kleihauer, E., editor, Künzer, W., editor, Lassrich, M. A., editor, Leiber, B., editor, Lindquist, B., editor, Marget, W., editor, Oehme, J., editor, Olbing, H., editor, Pfeiffer, R. A., editor, Prader, A., editor, Riegel, K., editor, Rossi, E., editor, Schärer, K., editor, Schmidt, E., editor, Schulte, F.-J., editor, Spiess, H., editor, Spranger, J., editor, Stalder, G., editor, Stephan, U., editor, Stoermer, J., editor, Ströder, J., editor, Teller, W., editor, Zetterström, R., editor, and Zweymüller, E., editor

Published
1980
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21. Temperature dependence of the double layer capacitance for the restricted primitive model of an electrolyte solution from a density functional approach.

Author

Reszko-Zygmunt, J., Soko&lslash;owski, S., Henderson, D., and Boda, D.

Subjects
DENSITY functionals, ELECTROLYTE solutions, ELECTROCHEMISTRY, COMPUTER simulation, LOW temperatures, CRYSTALLOGRAPHY
Abstract

We apply a different version of the density functional theory, given by Pizio, Patrykiejew, and Sokołowski [J. Chem. Phys. 121, 11957 (2004)], for a nonuniform restricted primitive model of an electrolyte solution to evaluate the temperature dependence of the capacitance of an electric double layer. We show that this theory is capable of reproducing the computer simulation data at a quantitative level. In particular, the reversal of the temperature dependence of the capacitance at low temperatures is predicted. This phenomenon has been difficult to predict from theory. Further, this theory also leads to an accurate description of the double layer structure. [ABSTRACT FROM AUTHOR]

Published
2005
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22. Neuroendocrine factors: The missing link in non-melanoma skin cancer (Review)

Author

Lupu, M. Caruntu, A. Caruntu, C. Papagheorghe, L.M.L. Ilie, M.A. Voiculescu, V. Boda, D. Constantin, C. Tanase, C. Sifaki, M. Drakoulis, N. Mamoulakis, C. Tzanakakis, G. Neagu, M. Spandidos, D.A. Izotov, B.N. Tsatsakis, A.M.

Abstract

Non-melanoma skin cancer (NMSC) is the most common form of cancer worldwide, comprising 95% of all cutaneous malignancies and approximately 40% of all cancers. In spite of intensive efforts aimed towards awareness campaigns and sun-protective measures, epidemiological data indicate an increase in the incidence of NMSC. This category of skin cancers has many common environmental triggers. Arising primarily on sun-exposed skin, it has been shown that ultraviolet radiation is, in the majority of cases, the main trigger involved in the pathogenesis of NMSC. Aside from the well-known etiopathogenic factors, studies have indicated that several neuroactive factors are involved in the carcinogenesis of two of the most common types of NMSC, namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), with the exception of penile SCC, for which a paucity of specific data on their pathogenic role exists. The complex interaction between the peripheral nervous system and target cells in the skin appears to be mediated by locally released neuroendocrine factors, such as catecholamines, substance P, calcitonin gene-related peptide and somatostatin, as well as neurohormones, such as proopiomelanocortin and its derived peptides, α-melanocyte-stimulating hormone and adrenocorticotropin. All these factors have been, at least at some point, a subject of debate regarding their precise role in the pathogenesis of NMSC. There is also a significant body of evidence indicating that psychological stress is a crucial impact factor influencing the course of skin cancers, including SCC and BCC. Numerous studies have suggested that neuroendocrine factor dysregulation, as observed in stress reactions, may be involved in tumorigenesis, accelerating the development and progression, and suppressing the regression of NMSC. Further studies are required in order to elucidate the exact mechanisms through which neuroactive molecules promote or inhibit cutaneous carcinogenesis, as this could lead to the development of more sophisticated and tailored treatment protocols, as well as open new perspectives in skin cancer research.

Published
2017

23. Real-time investigation of skin blood flow changes induced by topical capsaicin

Author

Ghiţă, M. A., Căruntu, C., Rosca, A. E., Căruntu, A., Moraru, L., Constantin Caruntu, Neagu, M., and Boda, D.

Subjects
Adult, Male, Young Adult, Regional Blood Flow, Administration, Topical, Humans, skin, blood flow, in vivo reflectance confocal microscopy, capsaicin, Female, Antipruritics, Capsaicin, Skin
Abstract

Capsaicin induces a localized inflammatory process known as neurogenic inflammation upon its topical administration on the skin, due to the release of various neuropeptides from the cutaneous sensory nerve endings. In this study, we investigated real-time skin blood flow changes that occur in neurogenic inflammation induced by topical capsaicin by means of in vivo reflectance confocal microscopy. 27 healthy subjects (15 women and 12 men, mean age ± Standard Deviation: 22.62±4.47) were administered topical capsaicin solution (Capsaicin group) or immersion oil (Control group) on the dorsal side of their non-dominant hand. At different time intervals during administration (0, 10, 25, and 40 minutes), cutaneous blood flow was evaluated using reflectance confocal microscopy and compared between the two groups. Blood flow values were higher during topical capsaicin, with significant increase after 25 (P=0.0160, Dunn’s multiple comparisons test) and 40 minutes (P=0.0132, Dunn’s multiple comparisons test) after its administration when compared with the initial 0 min value. Furthermore, the differences in the blood flow changes between the two groups were significant at 25 min (P=0.0182, Dunn’s multiple comparisons test) and 40 min (P=0.0296, Dunn’s multiple comparisons test) after capsaicin administration. Reflectance confocal microscopy allows in vivo, real-time evaluation of cutaneous blood flow changes within the capsaicin-induced inflammation, and this method might serve as a research model to test neurovascular reactivity.

Published
2017

27. The role of confocal microscopy in the dermato–oncology practice

Author

Diaconeasa, A, Boda, D, Neagu, M, Constantin, C, Căruntu, C, Vlădău, L, and Guţu, D

Subjects
Adult, Male, Microscopy, Confocal, Skin Neoplasms, dermatoscopy, Dermatology, Middle Aged, optical biopsy, Humans, Female, General Article, Algorithms, Aged, Retrospective Studies
Abstract

Reflectance-mode confocal microscopy (RCM) is a new in vivo skin imaging technique. We present our one-year experience in RCM examinations in skin tumors and the retrospective analysis of patients enrolled in the Dermatological Department of 'N. Paulescu' Institute using the Fotofinder Dermoscope IIŴ for the dermatoscopy analysis and VivaScope 1500Ŵ for in vivo RCM. We established the rank of RCM in the complex algorithm of skin cancer diagnose, showing that the presented experience can open new possibilities to implement this automated image analyzing system in the routine practice. Our analyzed cases clearly showed that confocal microscopy, therefore, optical biopsy, could guide the clinician towards an accurate diagnosis before surgical removal. Moreover, we emphasized that the development of this technique increases the potential of future teledermatologic applications.

Published
2011

28. HPV strain distribution in patients with genital warts in a female population sample

Author

Boda, D. Neagu, M. Constantin, C. Voinescu, R.N. Caruntu, C. Zurac, S. Spandidos, D.A. Drakoulis, N. Tsoukalas, D. Tsatsakis, A.M.

Abstract

The incidence of human papillomavirus (HPV) in the human cancer domain is still a subject of intensive study. In this study, we examined cervical swab samples from 713 females with genital warts, and tested the samples for high‑and low‑risk genital HPV. HPV genotyping was assessed using a Genotyping test that detects HPV by the amplification of target DNA using polymerase chain reaction and nucleic acid hybridization. In total, we detected 37 anogenital HPV DNA genotypes [6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 45, 51, 52, 53, 54, 55, 56, 58, 59, 61, 62, 64, 66, 67, 68, 69, 70, 71, 72, 73 (MM9), 81, 82 (MM4), 83 (MM7), 84 (MM8), IS39 and CP6108] and investigated the incidence of these genotypes in the patients with genital warts. We found differences in the distribution of high‑/low‑risk strains and the incidence of high‑risk strains was found to occur mainly in females under 35 years of age. The data from our study suggest that a detailed oral, rectal and genital identification of high‑risk strains should be performed to visualize the entire pattern of possible triggers of carcinogenesis. © 2016, Spandidos Publications. All rights reserved.

Published
2016

29. Professor Helmut Karte 60 Jahre

Author

Bachmann, K. D., Berger, H., Bierich, J., Boda, D., Bremer, H.-J., Brodehl, J., Burgio, G. R., Fischer, K., Gladtke, E., Hadorn, B., Hagberg, B., Hallman, N., Hansen, H. G., Harbauer, H., von Harnack, G.-A., Hecker, W. C., Helge, H., Hitzig, W. H., Huth, E., Kleihauer, E., Künzer, W., Lassrich, M. A., Leiber, B., Lindquist, B., Marget, W., Oehme, J., Olbing, H., Pfeiffer, R. A., Prader, A., Riegel, K., Rossi, E., Schärer, K., Schmidt, E., Schulte, F.-J., Spiess, H., Spranger, J., Stalder, G., Stephan, U., Stoermer, J., Ströder, J., Teller, W., Zetterström, R., Zweymüller, E., Bachmann, K. D., editor, Berger, H., editor, Bierich, J., editor, Boda, D., editor, Bremer, H.-J., editor, Brodehl, J., editor, Burgio, G. R., editor, Fischer, K., editor, Gladtke, E., editor, Hadorn, B., editor, Hagberg, B., editor, Hallman, N., editor, Hansen, H. G., editor, Harbauer, H., editor, von Harnack, G.-A., editor, Hecker, W. C., editor, Helge, H., editor, Hitzig, W. H., editor, Huth, E., editor, Kleihauer, E., editor, Künzer, W., editor, Lassrich, M. A., editor, Leiber, B., editor, Lindquist, B., editor, Marget, W., editor, Oehme, J., editor, Olbing, H., editor, Pfeiffer, R. A., editor, Prader, A., editor, Riegel, K., editor, Rossi, E., editor, Schärer, K., editor, Schmidt, E., editor, Schulte, F.-J., editor, Spiess, H., editor, Spranger, J., editor, Stalder, G., editor, Stephan, U., editor, Stoermer, J., editor, Ströder, J., editor, Teller, W., editor, Zetterström, R., editor, and Zweymüller, E., editor

Published
1980
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34. Monte Carlo simulation of the electrical properties of electrolytes adsorbed in charged slit-systems

Author

Kov��cs, R., Valisk��, M., and Boda, D.

Subjects
genetic structures, Astrophysics::Instrumentation and Methods for Astrophysics, Physics::Optics, Soft Condensed Matter (cond-mat.soft), FOS: Physical sciences, sense organs, eye diseases
Abstract

We study the adsorption of primitive model electrolytes into a layered slit system using grand canonical Monte Carlo simulations. The slit system contains a series of charged membranes. The ions are forbidden from the membranes, while they are allowed to be adsorbed into the slits between the membranes. We focus on the electrical properties of the slit system. We show concentration, charge, electric field, and electrical potential profiles. We show that the potential difference between the slit system and the bulk phase is mainly due to the double layers formed at the boundaries of the slit system, but polarization of external slits also contributes to the potential drop. We demonstrate that the electrical work necessary to bring an ion into the slit system can be studied only if we simulate the slit together with the bulk phases in one single simulation cell., 11 pages, 8 figures

Published
2012
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35. Study on the Cooling Effect of Double-Layer Spray Greenhouse

Author

Jihang Xu, Weitao Bai, Jian Wang, Zhihui Mu, Weizhen Sun, Boda Dong, Kai Song, Yalan Yang, Shirong Guo, Sheng Shu, and Yu Wang

Subjects
greenhouse cooling, fogging system, nozzle layout, microclimate, Agriculture (General), S1-972
Abstract

Greenhouses provide suitable environmental conditions for plant growth. Double-layer plastic greenhouses are often used in many regions to ensure normal crop growth during winter since single-layer plastic greenhouses have poor insulation. However, during summer, the high insulation of double-layer plastic greenhouses, combined with excessive external solar radiation, can cause high temperatures inside the greenhouse that are not suitable for plant growth and require cooling. In this study, we propose a double-layer spray greenhouse using a high-pressure spraying system that is placed inside the double film that allows for additional cooling capacity during the summer in order to sustain plant growth. A greenhouse platform test was set up to investigate the optimum operating conditions for the nozzles and to explore changes in greenhouse microclimate under different nozzle operating conditions. The results show that (1) the cooling rate increases with increasing water supply pressure, nozzle diameter and spraying time, and the humidification rate is consistent with the change in the rate of cooling. (2) The optimal condition for cooling in this experiment is achieved with a 120° double nozzle with a nozzle diameter of 0.30 mm, a water supply pressure of 6 MPa, and a spraying time of 15 min, which can reduce the temperature by up to 5.36 °C and serve as a reference for the summer cooling of the double-layer greenhouse.

Published
2023
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41. Poster session IV * Friday 10 December 2010, 14:00-18:00

Author

Mora, B., primary, Base, E., additional, Schmid, W., additional, Andreas, M., additional, Weber, U., additional, Junreitmaier, M., additional, Foerster, F., additional, Hiesmayr, M., additional, Tschernich, H. D., additional, Guldbrand, D., additional, Goetzsche, O., additional, Eika, B., additional, Fumagalli, S., additional, Francini, S., additional, Gabbai, D., additional, Pedri, S., additional, Casalone Rinaldi, M., additional, Makhanian, Y., additional, Sollami, R., additional, Tarantini, F., additional, Marchionni, N., additional, Azcarate, P. M., additional, Castano, S., additional, Rodriguez-Manero, M., additional, Arraiza, M., additional, Levy, B., additional, Barba, J., additional, Rabago, G., additional, Bastarrika, G., additional, Rus, H., additional, Radoi, M., additional, Ciurea, C., additional, Boda, D., additional, Erdei, T., additional, Denes, M., additional, Mihalcz, A., additional, Kardos, A., additional, Foldesi, C. S., additional, Temesvari, A., additional, Lengyel, M., additional, Cameli, M., additional, Lisi, M., additional, Righini, F., additional, Ballo, P., additional, Henein, M., additional, Mondillo, S., additional, Nistri, S., additional, Galderisi, M., additional, Ballo, P. C., additional, Pagliani, L., additional, Olivotto, I., additional, Santoro, A., additional, Papesso, B., additional, Innelli, P., additional, Cecchi, F., additional, Hristova, K., additional, Katova, T. Z., additional, Kostova, V., additional, Simova, Y., additional, Nesheva, N., additional, Ivanovic, B., additional, Tadic, M. T., additional, Simic, D. S., additional, Rao, C. M., additional, Aguglia, D., additional, Casciola, G., additional, Imbesi, C., additional, Marvelli, A., additional, Sgro, M., additional, Benedetto, D., additional, Tripepi, G., additional, Zoccali, C., additional, Benedetto, F. A., additional, Mantziari, L., additional, Kamperidis, V., additional, Damvopoulou, E., additional, Ventoulis, I., additional, Giannakoulas, G., additional, Paraskevaidis, S., additional, Vassilikos, V., additional, Karvounis, H., additional, Styliadis, I. H., additional, Sonder, T. K., additional, Loegstrup, B. B., additional, Lambrechtsen, J., additional, Van Bortel, L. M., additional, Segers, P., additional, Egstrup, K., additional, Tho, A., additional, Moceri, P., additional, Bertora, D., additional, Gibelin, P., additional, Cho, E. J., additional, Choi, K. Y., additional, Kim, B. J., additional, Kim, D. B., additional, Jang, S. W., additional, Park, C. S., additional, Jung, H. O., additional, Jeon, H. K., additional, Youn, H. J., additional, Kim, J. H., additional, Donal, E., additional, Coquerel, N., additional, Bodi, S., additional, Thebault, C., additional, Kervio, G., additional, Carre, F., additional, Daly, M. J., additional, Fairley, S. L., additional, Doherty, R., additional, Ashfield, K., additional, Kirkpatrick, R., additional, Smith, B., additional, Buchanan, J., additional, Hill, L., additional, Dixon, L. J., additional, Rosca, M., additional, O' Connor, K., additional, Magne, J., additional, Romano, G., additional, Calin, A., additional, Popescu, B. A., additional, Beladan, C. C., additional, Pierard, L., additional, Ginghina, C., additional, Lancellotti, P., additional, Bochenek, T., additional, Wita, K., additional, Tabor, Z., additional, Grabka, M., additional, Elzbieciak, M., additional, Trusz-Gluza, M., additional, Moreau, O., additional, Leclercq, C., additional, Sahlen, A., additional, Shahgaldi, K., additional, Aminoff, A., additional, Aagaard, P., additional, Manouras, A., additional, Winter, R., additional, Ehrenborg, E., additional, Braunschweig, F., additional, Bedetti, G., additional, Gargani, L., additional, Pizzi, C., additional, Sicari, R., additional, Picano, E., additional, Zhang, J., additional, Zhang, H. B., additional, Duan, Y. Y., additional, Chen, L. L., additional, Li, J., additional, Liu, L. W., additional, Zhu, T., additional, Li, H. L., additional, Su, H. L., additional, Zhou, X. D., additional, Ruiz Ortiz, M., additional, Mesa Rubio, D., additional, Delgado Ortega, M., additional, Romo Penas, E., additional, Toledano Degado, F., additional, Leon Del Pino, C., additional, Lopez Aguilera, J., additional, Villanueva Fernandez, E., additional, Cejudo Diaz Del Campo, L., additional, Suarez De Lezo, J., additional, Abergel, E., additional, Simon, M., additional, Dehant, P., additional, Bogino, E., additional, Jimenez, M., additional, Verdier, J. C., additional, Chauvel, C., additional, Albertsen, A. E., additional, Nielsen, J. C., additional, Mortensen, P. T., additional, Egeblad, H., additional, Nasr, G. M., additional, Tawfik, S., additional, Omar, A., additional, Olofsson, M., additional, Boman, K., additional, Rezzoug, N., additional, Vaes, B., additional, Degryse, J., additional, Vanoverschelde, J.-L., additional, Pasquet, A. A., additional, Poggio, D., additional, Bonadies, M., additional, Pacher, V., additional, Mazzetti, S., additional, Grillo, M., additional, D'elia, E., additional, Khouri, T., additional, Specchia, G., additional, Mornos, C., additional, Rusinaru, D., additional, Cozma, D., additional, Ionac, A., additional, Petrescu, L., additional, Rotzak, R., additional, Rosenman, Y., additional, Patterson, R. D., additional, Ratnatheepan, S., additional, Bogle, R. G., additional, Goebel, B., additional, Gjesdal, O., additional, Kottke, D., additional, Otto, S., additional, Jung, C., additional, Edvardsen, T., additional, Figulla, H. R., additional, Poerner, T. C., additional, Otsuka, T., additional, Suzuki, M., additional, Yoshikawa, H., additional, Hashimoto, G., additional, Itou, N., additional, Ono, T., additional, Yamamoto, M., additional, Osaki, T., additional, Tsuchida, T., additional, Sugi, K., additional, Wolber, T., additional, Haegeli, L., additional, Huerlimann, D., additional, Brunckhorst, C., additional, Duru, F., additional, Wu, Z. M., additional, Shu, X. H., additional, Dong, L. L., additional, Fan, B., additional, Ge, J. B., additional, Greutmann, M., additional, Tobler, D., additional, Biaggi, P., additional, Mah, M., additional, Crean, A., additional, Oechslin, E. N., additional, Silversides, C. K., additional, Giusca, S., additional, Jurcut, R., additional, Ghiorghiu, I., additional, Coman, I. M., additional, Amzulescu, M., additional, Ionescu, R., additional, Delcroix, M., additional, Voigt, J. U., additional, Piatkowski, R., additional, Kochanowski, J., additional, Scislo, P., additional, Grabowski, M., additional, Marchel, M., additional, Roik, M., additional, Kosior, D., additional, Opolski, G., additional, Maceira Gonzalez, A. M., additional, Cosin-Sales, J., additional, Dalli, E., additional, Igual, B., additional, Monmeneu, J. V., additional, Lopez-Lereu, P., additional, Estornell, J., additional, Ruvira, J., additional, Sotillo, J., additional, Stevanovic, A., additional, Toncev, A., additional, Dimkovic, S., additional, Dekleva, M., additional, Paunovic, N., additional, Toncev, D., additional, Sekularac, N., additional, Yildirimturk, O., additional, Helvacioglu, F. F., additional, Tayyareci, Y., additional, Yurdakul, S., additional, Demiroglu, I. C. C., additional, Aytekin, S., additional, Pinedo Gago, M., additional, Amat Santos, I., additional, Revilla Orodea, A., additional, Lopez Diaz, J., additional, Arnold, R., additional, De La Fuente Galan, L., additional, Recio Platero, A., additional, Gomez Salvador, I., additional, Puerto Sanz, A., additional, San Roman Calvar, J. A., additional, Yotti, R., additional, Bermejo, J., additional, Mombiela, T., additional, Benito, Y., additional, Sanchez, P. 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J., additional, Vallejo Camazon, N., additional, Gonzalez Guardia, A., additional, Nunez, R., additional, Bosch Carabante, C., additional, Mateu, L., additional, Gual Capllonch, F., additional, Ferrer Sistach, E., additional, Lopez Ayerbe, J., additional, Bayes Genis, A., additional, Tomaszewski, A., additional, Kutarski, A., additional, Tomaszewski, M., additional, Bramos, D., additional, Kalantaridou, A., additional, Takos, D., additional, Skaltsiotis, E., additional, Trika, C., additional, Tsirikos, N., additional, Pamboukas, C., additional, Kottis, G., additional, Toumanidis, S., additional, Aggeli, C., additional, Felekos, I., additional, Roussakis, G., additional, Kazazaki, C., additional, Lampropoulos, K., additional, Lagoudakou, S., additional, Stergiou, C., additional, Pitsavos, C., additional, Stefanadis, C., additional, Kihara, C., additional, Murata, K., additional, Wada, Y., additional, Tanaka, T., additional, Uchida, K., additional, Okuda, S., additional, Susa, T., additional, Matsuzaki, M., additional, Abrahamsson, A., additional, Gudmundsson, P., additional, Brodin, L., additional, Knebel, F., additional, Schattke, S., additional, Sanad, W., additional, Schimke, I., additional, Schroeckh, S., additional, Brechtel, L., additional, Lock, J., additional, Makauskiene, R., additional, Baumann, G., additional, Borges, A. 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N., additional, Keeley, F., additional, Bradley, T., additional, Jaeggi, E., additional, and Sahlen, H., additional

Published
2010
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46. Synthesis and characterization of MgAl2O4 spinel nanowires

Author

Xingcai Wu, Zhijian J. Han, Boda D. Zhang, and Yourong R. Tao

Subjects
Aluminium oxides, Materials science, Spinel, Nanowire, Mineralogy, Crystal growth, General Chemistry, Substrate (electronics), engineering.material, Chemical engineering, Transmission electron microscopy, Materials Chemistry, engineering, Graphite, Vapor–liquid–solid method
Abstract

MgAl2O4 spinel nanowires have been synthesized on an alumina substrate by reaction of magnesium oxide powders with graphite at 1350 °C in a flowing argon atmosphere. Transmission electron microscopy (TEM) images show that they have a diameter of 50–120 nm, and a length up to 500 micrometers. Meanwhile, coaxial nanostructures of spinel nanowires sheathed with alumina have been discovered. The growth process of the nanowires may be explained by a vapor–liquid–solid mechanism of bottom growth.

Published
2003
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47. CATECHOLAMINES INCREASE IN VITRO PROLIFERATION OF MURINE B16F10 MELANOMA CELLS.

Author

Caruntu, C., Boda, D., Constantin, C., Caruntu, A., and Neagu, M.

Subjects
*MELANOMA, *CATECHOLAMINES, *CANCER cell proliferation, *SKIN cancer, *CORTICOSTERONE, *NORADRENALINE, *ADRENALINE
Abstract

Context. Melanoma is the most aggressive skin cancer, with significant morbidity and mortality, and one factor that may influence the course of disease is stress. Objective. Our aim was to evaluate the effect of corticosterone, norepinephrine, epinephrine on murine B16F10 melanoma cells in vitro proliferation. Methods. B16F10 melanoma cells were treated with different concentrations of tested hormones. The proliferative capacity of melanoma cells was quantified by MTS assay and the cell viability was quantified as membrane integrity evaluation measured by lactate dehydrogenase (LDH) release. Results. B16F10 cells treated with corticosterone showed no significant changes. In contrast, norepinephrine exposure stimulated the cell proliferation (P = 0.0003). Treatment with 1 μM norepinephrine induced the highest increase in cell proliferation (OD 492 = 0.27 ± 0.02) statistically significant to both control (OD 492 = 0.17 ± 0.01; p = 0.0003), 10 nM norepinephrine (OD 492 = 0.16 ± 0.00; p = 0.0004) and 100 nM norepinephrine (OD 492 = 0.19 ± 0.01; p = 0.002). Likewise, treatment with epinephrine increased cell proliferation (p = 0.0004). Exposure to 5 μm epinephrine induced a stimulation of cell proliferation (OD 492 = 0.28 ± 0.02) significantly higher compared to controls (OD 492 = 0.17 ± 0.01; p = 0.0004), 50 nM epinephrine (OD 492 = 0.17 ± 0.00; p = 0.001) and 500 nM epinephrine (OD 492 = 0.173 ± 0.00; p = 0.001). Conclusions. Our results may open new perspectives concerning the link between stress hormones and melanoma, emphasizing a direct stimulating in vitro effect induced by catecholamines on melanoma B16F10 cells proliferation. [ABSTRACT FROM AUTHOR]

Published
2014
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50. A new simple tool for tonometric determination of the PCO2 in the gastrointestinal tract: in vitro and in vivo validation studies.

Author

Boda, D., Kaszaki, J., and Tálosi, G.

Subjects
TONOMETRY, GLAUCOMA diagnosis, GASTROINTESTINAL system, DIGESTIVE organs, FEASIBILITY studies
Abstract

Background and objective: Following the discovery of the feasibility of assessing the adequacy of the splanchnic perfusion by means of gastrotonometry, this technique became extensively used in clinical practice and in research. At present, high-technology instruments are available for the purpose. However, there is still a need for a simple, cheap tool that is easily applicable for patients of all ages. The present article describes such a tool and presents the results of in vitro and in vivo validation measurements with it. Methods: Balloon-free tonometric probes consisting of silicone rubber tubes were developed. In vitro measurements of the uptake of CO2 inside the probes and for comparison in a conventional ballooned intestinal tonometer were made in a closed container maintained at 37°C. In in vivo studies in anaesthetized dogs, the tonometric PCO2 values were determined with a tonometric probe and catheter introduced simultaneously into the ileum of the animals and the results were analysed by the Bland-Altman method. Results: The in vitro equilibration studies revealed that the filling media inside the probes equilibrated rapidly with the PCO2 content of the chamber. The data obtained from the in vivo investigations with the two different methods demonstrated a statistically significant linear association (correlation coefficient: 0.778, significance: P < 0.001). Conclusion: The new simple tonometric probe described appears to be a reliable tool with certain advantages for gastric tonometry. However, further studies are warranted before its general clinical use. [ABSTRACT FROM AUTHOR]

Published
2006
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