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991 results on '"Bockaert J"'

14. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer

Author

Ango, F., Prezeau, L., Muller, T., Tu, J. C., Xiao, B., Worley, P. F., Pin, J. P., Bockaert, J., and Fagni, L.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): F. Ango [1]; L. Prézeau [1]; T. Muller [2]; J. C. Tu [3]; B. Xiao [3]; P. F. Worley [3]; J. P. Pin [1]; J. Bockaert [1]; L. Fagni [...]

Published
2001
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24. Functional coupling between ryanodine receptors and L-type calcium channels in neurons

Author

Chavis, P., Fagni, L., Lansman, J.B., and Bockaert, J.

Subjects
Calcium channels -- Physiological aspects, Neurons -- Analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The stimulation of the type-1 metabotropic glutamate receptor (mGluR1) induces a tight functional coupling between ryanodine receptors and L-type calcium channels in neurons. The stimulation of mGluR1 facilitates L-type calcium channel activity. The stimulation of channel activity is independent of inositol 1,4,5-trisphosphate and typical protein kinases, and is mimicked by caffeine. Ryanodine inhibits both the mGluR1 and caffeine-induced increase in L-type calcium channels in neurons.

Published
1996

32. Glutamate stimulates insulin secretion and improves glucose tolerance in rats

Author

Bertrand, G., Puech, R., Loubatieres-Mariani, M.M., and Bockaert, J.

Subjects
Glutamate -- Physiological aspects, Blood sugar -- Observations, Insulin -- Agonists, Biological sciences
Abstract

Glutamate when administered intravenously and orally to rats enhances the secretion of insulin in vivo through an amino acid receptor and the ability to tolerate glucose is increased. Glutamate plays a role in the control of insulinemia and glycemia especially during the intake of food. The mammalian nervous system has glutamate as the main excitatory neurotransmitter, and it takes part in many neuronal functions such as learning, memory and the secretion of pituitary hormones.

Published
1995

36. 5-HT4 receptors

Author

Dumuis, A., primary, Ansanay, H., additional, Waeber, C., additional, Sebben, M., additional, Fagni, L., additional, and Bockaert, J., additional

Published
1997
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49. The state of GPCR research in 2004

Author

Bartfai, T., Benovic, J.L., Bockaert, J., Bond, R.A., Bouvier, M., Christopoulos, A., Civelli, O., Devi, L.A., George, S.R., Inui, A., Kobilka, B., Leurs, R., Neubig, R., Pin, J.P., Quirion, R., Roques, B.P., Sakmar, T.P., Seifert, R., Stenkamp, R.E., Strange, P.G., and Medicinal chemistry

Subjects
Pharmacology, Drug discovery, Research, General Medicine, Computational biology, Single class, Biology, Bioinformatics, Ligands, Receptors, G-Protein-Coupled, Drug Design, Drug Discovery, Animals, Humans, Technology, Pharmaceutical, G protein-coupled receptor
Abstract

List of questions G-protein-coupled receptors (GPCRs) comprise the largest single class of cell-surface receptors, and have a history of being excellent therapeutic targets for a number of diseases. Yet several fundamental questions remain regarding their underlying biology, and many GPCRs that could be promising targets for drug discovery are still uncharacterized at the level of identified ligand or biological function. In an attempt to find some answers, we posed 20 questions of fundamental importance to the future development of the field to 20 of the world's leading experts on GPCR research, and here we present their replies.

Published
2004

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