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5. The lung ultrasound in children with SARS-COV-2 infection: a national multicenter prospective study.

Author

Supino, Maria Chiara, Buonsenso, Danilo, Agostiniani, Rino, Gori, Laura, Tipo, Vincenzo, Morello, Rosa, Del Monaco, Giovanni, Falsaperla, Raffaele, Biagi, Carlotta, Cazzato, Salvatore, Villani, Alberto, Musolino, Anna Maria, Scateni, Simona, Ferro, Valentina, Scialanga, Barbara, Mesturino, Maria Alessia, Boccuzzi, Elena, Puxeddu, Roberta, D'Anna, Carolina, and Romagnoli, Vittorio

Subjects
SARS-CoV-2, COVID-19, OXYGEN saturation, OXYGEN therapy, LUNGS
Abstract

Coronavirus disease-19 (COVID-19) caused hospitalizations, severe disease, and deaths in any age, including in the youngest children. The aim of this multicenter national study is to characterize the clinical and the prognostic role of lung ultrasound (LU) in children with COVID-19. We enrolled children between 1 month and 18 years of age with severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection who underwent a LU within 6 h from the first medical evaluation. A total of 213 children were enrolled, 51.6% were male, median age was 2 years and 5 months (interquartile range (IQR) 4 months –11 years and 4 months). One hundred and forty-eight (69.4%) children were admitted in hospital, 9 (6.1%) in pediatric intensive care unit. We found an inverse correlation between the lung ultrasound score (LUS) and the oxygen saturation at the first clinical evaluation (r = −0.16; p = 0.019). Moreover, LUS was significantly higher in patients requiring oxygen supplementation (8 (IQR 3–19) vs 2 (IQR 0–4); p = 0.001). Among LU pathological findings, irregular pleural lines, subpleural consolidations, and pleural effusions were significantly more frequent in patients needing oxygen supplementation (p = 0.007, p = 0.006, and p = 0.001, respectively). Conclusion: This multicenter study showed that LU in children with COVID-19 can highlight pleural line irregularities, vertical artifacts, and subpleural consolidation. Notably, children with higher LUS have a higher risk of hospitalization and need for oxygen supplementation, supporting LU as a valid and safe point-of-care first level tool for the clinical evaluation of children with COVID-19. What is Known: • Few children infected with SARS-CoV-2 develop a severe disease and need oxygen therapy. • Lung ultrasound can easily detect low respiratory tract infection during SARS-CoV-2. What is New: • Children with higher lung ultrasound score have a higher risk of need for oxygen supplementation. • Irregular pleural line, sub-pleural consolidations and pleural effusions were significantly more frequent in patients needing oxygen supplementation. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Thelung ultrasound in children with SARS-COV 2 infection: a national multicenter prospective study

Author

Supino, Maria Chiara, primary, Buonsenso, Danilo, additional, Agostiniani, Rino, additional, Gori, Laura, additional, Tipo, Vincenzo, additional, Morello, Rosa, additional, Monaco, Giovanni Del, additional, Falsaperla, Raffaele, additional, Biagi, Carlotta, additional, Cazzato, Salvatore, additional, Villani, Alberto, additional, Musolino, Anna Maria, additional, Scateni, Simona, additional, Ferro, Valentina, additional, Scialanga, Barbara, additional, Mesturino, Maria Alessia, additional, Boccuzzi, Elena, additional, D’Anna, Carolina, additional, Romagnoli, Vittorio, additional, Marino, Silvia, additional, Puxeddu, Roberta, additional, and Martinelli, Gaia, additional

Published
2024
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7. Atraumatic Limping Child, a Challenge for Pediatricians: An Observational Age-Related Study in a Pediatric Emergency Department

Author

Cristaldi, Sebastian, primary, Boni, Alessandra, additional, Ferro, Valentina, additional, Musolino, Antonio, additional, Della Vecchia, Nicoletta, additional, Boccuzzi, Elena, additional, Bellelli, Elena, additional, Biagiarelli, Francesco Saverio, additional, Aulisa, Angelo Gabriele, additional, Cirillo, Marco, additional, Raucci, Umberto, additional, and Villani, Alberto, additional

Published
2024
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9. The lung ultrasound in children with SARS-COV 2 infection: a national multicenter prospective study

Author

Supino, Maria, primary, Buonsenso, Danilo, additional, Agostiniani, Rino, additional, Gori, Laura, additional, Tipo, Vincenzo, additional, Morello, Rosa, additional, Delmonaco, Angelo Giovanni, additional, Falsaperla, Raffaele, additional, Biagi, Carlotta, additional, Cazzato, Salvatore, additional, Villani, Alberto, additional, Musolino, Anna Maria, additional, Scateni, Simona, additional, Ferro, Valentina, additional, Scialanga, Barbara, additional, Mesturino, Alessia, additional, Boccuzzi, Elena, additional, D'Anna, Carolina, additional, Romagnoli, Vittorio, additional, Marino, Silvia, additional, Puxeddu, Roberta, additional, Martelli, Gaia, additional, Gagliardo, Thaililja, additional, Murciano, Manuel, additional, and Pellizzoni, Federica, additional

Published
2023
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15. Lung Ultrasound to Detect Pneumothorax in Children Evaluated for Acute Chest Pain in the Emergency Department: An Observational Pilot Study

Author

Scialanga, Barbara, Buonsenso, Danilo, Scateni, Simona, Valentini, Piero, Schingo, Paolo Maria Salvatore, Boccuzzi, Elena, Mesturino, Maria Alessia, Ferro, Valentina, Chiaretti, Antonio, Villani, Alberto, Supino, Maria Chiara, Musolino, Anna Maria, Valentini, Piero (ORCID:0000-0001-6095-9510), Chiaretti, Antonio (ORCID:0000-0002-9971-1640), Scialanga, Barbara, Buonsenso, Danilo, Scateni, Simona, Valentini, Piero, Schingo, Paolo Maria Salvatore, Boccuzzi, Elena, Mesturino, Maria Alessia, Ferro, Valentina, Chiaretti, Antonio, Villani, Alberto, Supino, Maria Chiara, Musolino, Anna Maria, Valentini, Piero (ORCID:0000-0001-6095-9510), and Chiaretti, Antonio (ORCID:0000-0002-9971-1640)

Abstract

BackgroundSpontaneous pneumothorax is a relatively uncommon and poorly studied condition in children. While several protocols have been developed to evaluate the use of lung ultrasound for dyspneic adult patients in the emergency department, no specific guidelines are present for pediatric emergency physicians. ObjectivesWe prospectively analyzed children with acute chest pain and clinical suspicion of pneumothorax evaluated at the pediatric emergency department. MethodsWe consecutively enrolled children aged 5-17 years presenting to the pediatric emergency department with clinically suspected pneumothorax based on sudden onset of acute chest pain. After clinical examination, all children underwent lung ultrasound followed by chest X-ray (reference standard). We enrolled 77 children, of which 13 (16.9%) received a final diagnosis of pneumothorax. ResultsThe lung point had a sensitivity of 92.3% (95% CI 77.8-100) and a specificity of 100% (95% CI 94.4-100) for the detection of pneumothorax. The "barcode sign" had a sensitivity of 100% (95% CI 75.3-100) and a specificity of 100% (95% CI 94.4-100) for the detection of pneumothorax. ConclusionLung ultrasound is highly accurate in detecting or excluding pneumothorax in children with acute chest pain evaluated in the pediatric emergency department. If pneumothorax is suspected, but the lung point is not visible, the barcode sign should always be sought as it could be a form of massive pneumothorax.

Published
2022

16. One Year of Lung Ultrasound in Children with SARS-CoV-2 Admitted to a Tertiary Referral Children’s Hospital: A Retrospective Study during 2020–2021

Author

Musolino, Anna Maria, primary, Ferro, Valentina, additional, Supino, Maria Chiara, additional, Boccuzzi, Elena, additional, Scateni, Simona, additional, Sinibaldi, Serena, additional, Cursi, Laura, additional, Schingo, Paolo Maria Salvatore, additional, Reale, Antonino, additional, Campana, Andrea, additional, Raponi, Massimiliano, additional, Villani, Alberto, additional, and Tomà, Paolo, additional

Published
2022
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19. Lung Ultrasound to Detect Pneumothorax in Children Evaluated for Acute Chest Pain in the Emergency Department: An Observational Pilot Study

Author

Scialanga, Barbara, primary, Buonsenso, Danilo, additional, Scateni, Simona, additional, Valentini, Piero, additional, Schingo, Paolo Maria Salvatore, additional, Boccuzzi, Elena, additional, Mesturino, Maria Alessia, additional, Ferro, Valentina, additional, Chiaretti, Antonio, additional, Villani, Alberto, additional, Supino, Maria Chiara, additional, and Musolino, Anna Maria, additional

Published
2022
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20. Ten Years of Pediatric Lung Ultrasound: A Narrative Review

Author

Musolino, Anna Maria, primary, Tomà, Paolo, additional, De Rose, Cristina, additional, Pitaro, Eugenio, additional, Boccuzzi, Elena, additional, De Santis, Rita, additional, Morello, Rosa, additional, Supino, Maria Chiara, additional, Villani, Alberto, additional, Valentini, Piero, additional, and Buonsenso, Danilo, additional

Published
2022
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21. The Role of Lung Ultrasound in Diagnosing COVID-19-Related Multisystemic Inflammatory Disease: A Preliminary Experience

Author

Musolino, Anna Maria, primary, Boccuzzi, Elena, additional, Buonsenso, Danilo, additional, Supino, Maria Chiara, additional, Mesturino, Maria Alessia, additional, Pitaro, Eugenio, additional, Ferro, Valentina, additional, Nacca, Raffaella, additional, Sinibaldi, Serena, additional, Palma, Paolo, additional, Villani, Alberto, additional, and Tomà, Paolo, additional

Published
2022
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22. One year of Lung Ultrasound in children with SarsCoV2 infection admitted to a tertiary referral children’s hospital: a retrospective, single-center study, during 2020-2021 period.

Author

Musolino, Anna Maria, primary, Ferro, Valentina, additional, Supino, Maria Chiara, additional, Boccuzzi, Elena, additional, Scateni, Simona, additional, Sinibaldi, Serena, additional, Cursi, Laura, additional, Schingo, Paolo Maria, additional, Reale, Antonino, additional, Campana, Andrea, additional, Raponi, Massimiliano, additional, Villani, Alberto, additional, and Toma, Paolo, additional

Published
2021
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23. Ten Years of Pediatric Lung Ultrasound: A Narrative Review

Author

Musolino, Anna Maria, Tomà, Paolo, De Rose, Cristina, Pitaro, Eugenio, Boccuzzi, Elena, De Santis, Rita, Morello, Rosa, Supino, Maria Chiara, Villani, Alberto, Valentini, Piero, Buonsenso, Danilo, Valentini, Piero (ORCID:0000-0001-6095-9510), Musolino, Anna Maria, Tomà, Paolo, De Rose, Cristina, Pitaro, Eugenio, Boccuzzi, Elena, De Santis, Rita, Morello, Rosa, Supino, Maria Chiara, Villani, Alberto, Valentini, Piero, Buonsenso, Danilo, and Valentini, Piero (ORCID:0000-0001-6095-9510)

Abstract

Lung diseases are the most common conditions in newborns, infants, and children and are also the primary cause of death in children younger than 5 years old. Traditionally, the lung was not thought to be a target for an ultrasound due to its inability to penetrate the gas-filled anatomical structures. With the deepening of knowledge on ultrasound in recent years, it is now known that the affected lung produces ultrasound artifacts resulting from the abnormal tissue/gas/tissue interface when ultrasound sound waves penetrate lung tissue. Over the years, the application of lung ultrasound (LUS) has changed and its main indications in the pediatric population have expanded. This review analyzed the studies on lung ultrasound in pediatrics, published from 2010 to 2020, with the aim of highlighting the usefulness of LUS in pediatrics. It also described the normal and abnormal appearances of the pediatric lung on ultrasound as well as the benefits, limitations, and possible future challenges of this modality.

Published
2021

24. Incidence and severity of pertussis hospitalisations in infants aged less than 1 year in 37 hospitals of six EU/EEA countries, results of PERTINENT sentinel pilot surveillance system, December 2015 to December 2018

Author

Merdrignac, Lore, Aït El Belghiti, Fatima, Pandolfi, Elisabetta, Jané, Mireia, Murphy, Jane, Fabiánová, Kateřina, García Cenoz, Manuel, Flem, Elmira, Guillot, Sophie, Tozzi, Alberto E, Carmona, Gloria, Habington, Adele, Zavadilová, Jana, Navasués, Ana, Bøås, Håkon, Lévy-Brühl, Daniel, Ferretti, Beatrice, Lanaspa, Miguel, O’Sullivan, Niam, Křížová, Pavla, Fernandino, Leticia, Bekkevold, Terese, Hanslik, Thomas, Muñoz-Almagro, Carmen, Bacci, Sabrina, Spiteri, Gianfranco, Valenciano, Marta, Moren, Alain, Savulescu, Camelia, Blechová, Zuzana, Bláhová, Květa, Kosina, Pavel, Sýkora, Josef, Holčíková, Alena, Širůček, Petr, Grembombo, Adèle, Brisse, Sylvain, Toubiana, Julie, Cotter, Suzanne, Cunney, Robert, O’Shaughnessy, Norma, O’Sullivan, Niamh, Rizzo, Caterina, Russo, Luisa, Campagna, Ilaria, Gesualdo, Francesco, Ciampini, Sara, Annarosa Ferro, Valentina, Boccuzzi, Elena, Vazquez Fernandez, Liliana, Esteva, Cristina, Lanaspa Perez, Miguel, Acosta, Lesly, Jordan Garcia, Yolanda, Navascués, Ana, Fernandino Zubieta, Leticia, Castilla, Jesús, EpiConcept [Paris], Direction des maladies infectieuses - Infectious Diseases Division [Saint-Maurice], Santé publique France - French National Public Health Agency [Saint-Maurice, France], IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Public Health Agency of Catalonia [Barcelona, Spain] (PHAC), Temple Street Children's University Hospital [Dublin], National Institute of Public Health [Prague], Instituto de Investigación Sanitaria de Navarra [Pamplona, Spain] (IdiSNA), Norwegian Institute of Public Health [Oslo] (NIPH), Biodiversité et Epidémiologie des Bactéries pathogènes - Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur [Paris] (IP), Our Lady's Children's Hospital Crumlin (OLCHC), Complejo Hospitalario de Navarra, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu [Barcelona, Spain], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Universitat Internacional de Catalunya, CIBER de Epidemiología y Salud Pública (CIBERESP), European Centre for Disease Prevention and Control [Stockholm, Sweden] (ECDC), The European Centre for Disease Prevention and Control (ECDC) funded the PERTINENT study (Framework contract n° ECDC/2015/017)., PERTINENT group : Epiconcept, France: Lore Merdrignac, Epiconcept, Camelia Savulescu, Epiconcept, Marta Valenciano, Epiconcept, Alain Moren, Epiconcept. Czech Republic: Pavla Křížová, National Institute of Public Health, Prague, Kateřina Fabiánová, National Institute of Public Health, Prague, Jana Zavadilová, National Institute of Public Health, Prague, Zuzana Blechová, University Hospital Na Bulovce, Prague, Květa Bláhová, University Hospital Motol, Prague, Pavel Kosina, University Hospital, Hradec Králové, Josef Sýkora, University Hospital, Pilsen, Alena Holčíková, University Hospital, Brno, Petr Širůček, University Hospital, Ostrava. France: Daniel Lévy-Brühl, Santé Publique France, Saint-Maurice, Fatima Aït El Belghiti, Santé Publique France, Saint-Maurice, Adèle Grembombo, Santé Publique France, Saint-Maurice, Sophie Guillot, Institut Pasteur, Paris, Sylvain Brisse, Institut Pasteur, Paris, Julie Toubiana, Institut Pasteur, Paris. Ireland: Suzanne Cotter, HSE-Health Protection Surveillance Centre, Dublin, Jane Murphy, Temple Street Children’s University Hospital, Dublin, Robert Cunney, Temple Street Children’s University Hospital, Dublin, Norma O’Shaughnessy, Temple Street Children’s University Hospital, Dublin, Adele Habington, Our Lady’s Children’s hospital Crumlin, Dublin, Niamh O’Sullivan, Our Lady’s Children’s hospital Crumlin, Dublin. Italy: Elisabetta Pandolfi, Bambino Gesù Children Hospital, Rome, Alberto E Tozzi, Bambino Gesù Children Hospital, Rome, Caterina Rizzo, Bambino Gesù Children Hospital, Rome, Luisa Russo, Bambino Gesù Children Hospital, Rome, Ilaria Campagna, Bambino Gesù Children Hospital, Rome, Francesco Gesualdo, Bambino Gesù Children Hospital, Rome, Sara Ciampini, Bambino Gesù Children Hospital, Rome, Valentina Annarosa Ferro, Bambino Gesù Children Hospital, Rome, Elena Boccuzzi, Bambino Gesù Children Hospital, Rome. Norway: Elmira Flem, Norwegian Institute of Public Health, Oslo, Håkon Bøås, Norwegian Institute of Public Health, Oslo, Terese Bekkevold, Norwegian Institute of Public Health, Oslo, Liliana Vazquez Fernandez, Norwegian Institute of Public Health, Oslo. Catalonia, Spain: Carmen Muñoz-Almagro, Instituto de Recerca Pediatrica Hospital Sant Joan de Deu, Barcelona, Universitat Internacional de Catalunya and CIBER of Epidemiology and Public Health CIBERESP, Cristina Esteva, Instituto de Recerca Pediatrica Hospital Sant Joan de Deu, Barcelona, CIBER of Epidemiology and Public Health CIBERESP, Miguel Lanaspa Perez, Instituto de Recerca Pediatrica Hospital Sant Joan de Deu, Barcelona, Mireia Jané, Public Health Agency of Catalonia, Barcelona, University of Barcelona, Gloria Carmona, Public Health Agency of Catalonia, Barcelona, Lesly Acosta, Universitat Politècnica de Catalunya - BarcelonaTech (UPC), Public Health Agency of Catalonia, Barcelona, Yolanda Jordan Garcia, Instituto de Recerca Pediatrica Hospital Sant Joan de Deu, Barcelona, CIBER of Epidemiology and Public Health CIBERESP. Navarra, Spain: Manuel García Cenoz, Instituto de Salud Pública de Navarra, IdiSNA – Navarre Institute for Health Research, Pamplona, Ana Navascués, Complejo Hospitalario de Navarra, Pamplona, Leticia Fernandino Zubieta, Instituto de Salud Pública de Navarra, IdiSNA – Navarre Institute for Health Research, Pamplona, Jesús Castilla, Instituto de Salud Pública de Navarra, IdiSNA - Navarre Institute for Health Research, Pamplona. Sentinelles, France: Thomas Hanslik, Sorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris. ECDC: Sabrina Bacci, European Centre for Disease Prevention and Control, Stockholm, Sweden, Gianfranco Spiteri, European Centre for Disease Prevention and Control, Stockholm, Sweden., Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. ADBD - Anàlisi de Dades Complexes per a les Decisions Empresarials, Brisse, Sylvain, European Centre for Disease Prevention and Control (ECDC), and Institut Pasteur [Paris]

Subjects
Male, 0301 basic medicine, Bordetella pertussis, Pediatrics, Whooping Cough, Epidemiology, Infants -- Salut i Higiene, Hospitals - Admission and discharge, Children -- Health and hygiene, Infants (Newborn), 0302 clinical medicine, Interquartile range, pertussis incidence, 030212 general & internal medicine, Vacunació, Czech Republic, media_common, Pertussis Vaccine, Babies, Surveillance, biology, Norway, Incidence, Incidence (epidemiology), pertussis, Vaccination, Gestational age, Hospitals -- Ingressos i altes, Hospitals, 3. Good health, Europe, Hospitalization, Italy, Nodrissons, hospital surveillance, France, Niños -- Salud e higiene, medicine.medical_specialty, 030106 microbiology, Hospitales -- Admisión y alta, 03 medical and health sciences, Virology, Intensive care, medicine, Humans, media_common.cataloged_instance, Tos ferina, European Union, European union, Disease burden, Aged, Whooping cough, business.industry, Infants nadons -- Malalties, active surveillance, Infant, Newborn, Public Health, Environmental and Occupational Health, Vacunación, Infant, biology.organism_classification, Tosferina, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Lactantes, business, Ireland, Ciències de la salut [Àrees temàtiques de la UPC]
Abstract

Introduction PERTINENT is a pilot active surveillance system of infants hospitalised with pertussis in six European Union/European Economic Area countries (37 hospitals, seven sites). Aim This observational study aimed to estimate annual pertussis incidence per site from 2016 to 2018 and respective trends between 2017 and 2018. Pertussis cases were described, including their severity. Methods We developed a generic protocol and laboratory guidelines to harmonise practices across sites. Cases were hospitalised infants testing positive for Bordetella pertussis by PCR or culture. Sites collected demographic, clinical, laboratory data, vaccination status, and risk/protective factors. We estimated sites’ annual incidences by dividing case numbers by the catchment populations. Results From December 2015 to December 2018, we identified 469 cases (247 males; 53%). The median age, birthweight and gestational age were 2.5 months (range: 0–11.6; interquartile range (IQR): 2.5), 3,280 g (range: 700–4,925; IQR: 720) and 39 weeks (range: 25–42; IQR: 2), respectively. Thirty cases (6%) had atypical presentation either with cough or cyanosis only or with absence of pertussis-like symptoms. Of 330 cases with information, 83 (25%) were admitted to intensive care units including five deceased infants too young to be vaccinated. Incidence rate ratios between 2018 and 2017 were 1.43 in Czech Republic (p = 0.468), 0.25 in Catalonia (p = 0.002), 0.71 in France (p = 0.034), 0.14 in Ireland (p = 0.002), 0.63 in Italy (p = 0.053), 0.21 in Navarra (p = 0.148) and zero in Norway. Conclusions Incidence appeared to decrease between 2017 and 2018 in all but one site. Enhanced surveillance of hospitalised pertussis in Europe is essential to monitor pertussis epidemiology and disease burden.

Published
2021

25. Clinical report and predictors of sequelae of 319 cases of pediatric bacterial osteomyelitis.

Author

Krzysztofiak, Andrzej, Roversi, Marco, Musolino, Antonio, Cirillo, Marco, Toniolo, Renato Maria, Mazza, Osvaldo, Gargiullo, Livia, Lancella, Laura, Rossi, Paolo, Villani, Alberto, Collaborative Osteomyelitis Study Group, Barbuti, Domenico, Bernardi, Stefania, Bernaschi, Paola, Biagiarelli, Francesco, Boccuzzi, Elena, Bozzola, Elena, Carducci, Francesca Ippolita Calò, Chiurchiù, Sara, and Crostelli, Marco

Subjects
OSTEOMYELITIS, DISEASE complications, CHILDREN'S hospitals, INTRAVENOUS therapy
Abstract

Pediatric osteomyelitis is an insidious disease that can lead to permanent sequelae, the management of which still relies on lengthy intravenous antibiotic therapy. The purpose of this study is to report and describe the clinical course and outcome of pediatric bacterial osteomyelitis in our experience. We reported the clinical, diagnostic, and treatment characteristics of all cases of osteomyelitis in children younger than 18 years of age who were hospitalized between January 2010 and December 2021 at the Bambino Gesù Children's Hospital in Rome, Italy, we compared patients with and without complications at follow-up, to identify any predictive factor for sequelae. The study sample included 319 cases of pediatric bacterial osteomyelitis. The median age was 7.77 years. Males (60.8%) were more affected than females. The most affected bones were the femur, tibia, and spine. Etiology was identified in 40.1% of cases, with S.aureus as the most common causative agent. Sequelae were reported in 43 cases (13.5%). The main predictors of sequelae were sepsis on admission and hypergammaglobulinemia. Our results show that a severe presentation with sepsis and hypergammaglobulinemia on admission may be associated with a higher frequency of late sequelae. Early recognition and aggressive treatment of this subgroup of patients may lead to a reduction in complications. [ABSTRACT FROM AUTHOR]

Published
2022
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26. The impact of pertussis in infants: insights from a hospital-based enhanced surveillance system, Lazio region, Italy, 2016 to 2019

Author

Pandolfi, Elisabetta, primary, Gesualdo, Francesco, additional, Rizzo, Caterina, additional, Russo, Luisa, additional, Campagna, Ilaria, additional, Carloni, Emanuela, additional, Concato, Carlo, additional, Linardos, Giulia, additional, Villani, Alberto, additional, Ciampini, Sara, additional, Reale, Antonino, additional, Boccuzzi, Elena, additional, Midulla, Fabio, additional, and Tozzi, Alberto E, additional

Published
2021
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29. Lung Ultrasound to Detect Pneumothorax in Children Evaluated for Acute Chest Pain in the Emergency Department: An Observational Pilot Study

Author

Scialanga, Barbara, primary, Buonsenso, Danilo, additional, Supino, Mqariachiara, additional, Scateni, Simona, additional, Valentini, Piero, additional, Schingo, Paolo, additional, Boccuzzi, Elena, additional, Mesturino, Alessia, additional, Ferro, Valentina, additional, Chiaretti, Antonio, additional, and Musolino, Annamaria, additional

Published
2021
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34. Point of care ultrasound in the paediatric acute care setting: Getting to the 'heart' of respiratory distress.

Author

Musolino, Anna M, Buonsenso, Danilo, Massolo, Anna C, Gallo, Mariasara, Supino, Maria C, and Boccuzzi, Elena

Subjects
ULTRASONIC imaging, CHILD patients, EMERGENCY physicians, HEART diseases, FEDERAL aid, RESPIRATORY therapists, PEDIATRIC emergency services
Abstract

Point‐of‐care ultrasound (POCUS) is a growing interesting tool in the emergency setting. Its usefulness in diagnostic and therapeutic pathway of patients with respiratory distress in addition to clinical evaluation is well established in adult emergency medicine while paediatric specific data, although growing, remain limited. We report a case series of paediatric patients presenting with respiratory distress successfully diagnosed with cardiac dysfunction following POCUS evaluations. Lung POCUS, in combination with cardiac POCUS, is a very useful supplementary diagnostic tool to assess the breathless child and to rapidly identify life‐threatening primary etiologies or secondary physiologies. Thus, fast echocardiography is a desirable aid for paediatric emergency physicians and should be supported in all paediatric emergency settings following an adequate training that is mandatory regarding image acquisition and data interpretation. [ABSTRACT FROM AUTHOR]

Published
2021
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35. Uncommon Presentation of Childhood Leukemia in Emergency Department

Author

Boccuzzi, Elena, Ferro, Valentina A., Cinicola, Bianca, Schingo, Paolo M., Strocchio, Luisa, and Raucci, Umberto

Abstract

Leukemia is the most common childhood malignancy, and it is often characterized by pallor, fatigue, cytopenia, and organomegaly; sometimes musculoskeletal symptoms, mainly characterized by diffuse bone pain in the lower extremities, are the onset clinical characteristics of the disease. In these cases, the disease may initially be misdiagnosed as reactive arthritis, osteomyelitis, or juvenile idiopathic arthritis delaying appropriate diagnosis and management. Even if leukopenia, thrombocytopenia, and a history of nighttime pain are reported to be the most important predictive factors for a pediatric leukemia, blood examinations can sometimes be subtle or within normal limits, and this represents a further diagnostic difficulty. Radiological findings of leukemic bone involvement are described in patients with musculoskeletal symptoms of acute lymphoblastic leukemia and often appear before hematologic anomalies, but they are not specific for the disease. However, they could be helpful to get the right diagnosis if integrated with other features; thus, it is important knowing them, and it is mandatory for the multidisciplinary comparison to talk about dubious cases even in an emergency setting. We describe 4 patients visited in the emergency department for musculoskeletal complaints and having radiological lesions and a final diagnosis of acute lymphoblastic leukemia, in whom the onset of the manifestations could mimic orthopedic/rheumatologic diseases.

Published
2024
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37. Acute cerebellitis in children: An eleven year retrospective multicentric study in Italy

Author

Lancella, Laura, Esposito, Susanna, Galli, Maria Luisa, Bozzola, Elena, Labalestra, Valeria, Boccuzzi, Elena, Krzysztofiak, Andrzej, Cursi, Laura, Gattinara, Guido Castelli, Mirante, Nadia, Buonsenso, Danilo, Tagliabue, Claudia, Castellazzi, Luca, Montagnani, Carlotta, Tersigni, Chiara, Valentini, Piero, Capozza, Michele, Pata, Davide, Di Gangi, Maria, Dones, Piera, Garazzino, Silvia, Baroero, Luca, Verrotti, Alberto, Melzi, Maria Luisa, Sacco, Michele, Germano, Michele, Greco, Filippo, Uga, Elena, Crichiutti, Giovanni, Villani, Alberto, Valentini, Piero (ORCID:0000-0001-6095-9510), Lancella, Laura, Esposito, Susanna, Galli, Maria Luisa, Bozzola, Elena, Labalestra, Valeria, Boccuzzi, Elena, Krzysztofiak, Andrzej, Cursi, Laura, Gattinara, Guido Castelli, Mirante, Nadia, Buonsenso, Danilo, Tagliabue, Claudia, Castellazzi, Luca, Montagnani, Carlotta, Tersigni, Chiara, Valentini, Piero, Capozza, Michele, Pata, Davide, Di Gangi, Maria, Dones, Piera, Garazzino, Silvia, Baroero, Luca, Verrotti, Alberto, Melzi, Maria Luisa, Sacco, Michele, Germano, Michele, Greco, Filippo, Uga, Elena, Crichiutti, Giovanni, Villani, Alberto, and Valentini, Piero (ORCID:0000-0001-6095-9510)

Abstract

Background: Acute cerebellitis (AC) and acute cerebellar ataxia (ACA) are the principal causes of acute cerebellar dysfunction in childhood. Nevertheless. there is no accepted consensus regarding the best management of children with AC/ACA: the aim of the study is both to assess clinical, neuroimaging and electrophysiologic features of children with AC/ACA and to evaluate the correlation between clinical parameters, therapy and outcome. Methods: A multicentric retrospective study was conducted on children ≤ 18 years old admitted to 12 Italian paediatric hospitals for AC/ACA from 01/01/2003 to 31/12/2013. A score based on both cerebellar and extracerebellar signs/symptoms was computed for each patient. One point was given for each sign/symptom reported. Severity was divided in three classes: low, moderate, severe. Results: A total of 124 children were included in the study. Of these, 118 children received a final diagnosis of ACA and 6 of AC. The most characteristic finding of AC/ACA was a broad-based gait disturbance. Other common symptoms included balance disturbances, slurred speech, vomiting, headache and fever. Neurological sequelae were reported in 6 cases (5%) There was no correlation among symptoms, cerebrospinal fluid findings, clinical outcome. There was no correlation between clinical manifestations and clinical score on admission and length of hospital stay, sex, age and EEG findings with sequelae (P > 0.05). Children with pathological magnetic resonance imaging (MRI) or computed tomography (CT) had a higher probability of having clinical sequelae. Treatment was decided independently case by case. Patients with a higher clinical score on admission had a higher probability of receiving intravenous steroids. Conclusions: We confirmed the literature data about the benign course of AC/ACA in most cases but we also highlighted a considerable rate of patients with neurological sequelae (5%). Pathological MRI or CT findings at admission correlate to neurologi

Published
2017

38. Acute cerebellitis in children: an eleven year retrospective multicentric study in Italy

Author

Lancella, Laura, primary, Esposito, Susanna, additional, Galli, Maria Luisa, additional, Bozzola, Elena, additional, Labalestra, Valeria, additional, Boccuzzi, Elena, additional, Krzysztofiak, Andrzej, additional, Cursi, Laura, additional, Gattinara, Guido Castelli, additional, Mirante, Nadia, additional, Buonsenso, Danilo, additional, Tagliabue, Claudia, additional, Castellazzi, Luca, additional, Montagnani, Carlotta, additional, Tersigni, Chiara, additional, Valentini, Piero, additional, Capozza, Michele, additional, Pata, Davide, additional, Di Gangi, Maria, additional, Dones, Piera, additional, Garazzino, Silvia, additional, Baroero, Luca, additional, Verrotti, Alberto, additional, Melzi, Maria Luisa, additional, Sacco, Michele, additional, Germano, Michele, additional, Greco, Filippo, additional, Uga, Elena, additional, Crichiutti, Giovanni, additional, and Villani, Alberto, additional

Published
2017
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40. Pediatric Tuberculosis in Italian Children: Epidemiological and Clinical Data from the Italian Register of Pediatric Tuberculosis

Author

Galli, Luisa, primary, Lancella, Laura, additional, Tersigni, Chiara, additional, Venturini, Elisabetta, additional, Chiappini, Elena, additional, Bergamini, Barbara, additional, Codifava, Margherita, additional, Venturelli, Cristina, additional, Tosetti, Giulia, additional, Marabotto, Caterina, additional, Cursi, Laura, additional, Boccuzzi, Elena, additional, Garazzino, Silvia, additional, Tovo, Pier, additional, Pinon, Michele, additional, Le Serre, Daniele, additional, Castiglioni, Laura, additional, Lo Vecchio, Andrea, additional, Guarino, Alfredo, additional, Bruzzese, Eugenia, additional, Losurdo, Giuseppe, additional, Castagnola, Elio, additional, Bossi, Grazia, additional, Marseglia, Gian, additional, Esposito, Susanna, additional, Bosis, Samantha, additional, Grandolfo, Rita, additional, Fiorito, Valentina, additional, Valentini, Piero, additional, Buonsenso, Danilo, additional, Domenici, Raffaele, additional, Montesanti, Marco, additional, Salvini, Filippo, additional, Riva, Enrica, additional, Dodi, Icilio, additional, Maschio, Francesca, additional, Abbagnato, Luisa, additional, Fiumana, Elisa, additional, Fornabaio, Chiara, additional, Ballista, Patrizia, additional, Portelli, Vincenzo, additional, Bottone, Gabriella, additional, Palladino, Nicola, additional, Valenzise, Mariella, additional, Vecchi, Barbara, additional, Di Gangi, Maria, additional, Lupi, Carla, additional, Villani, Alberto, additional, and de Martino, Maurizio, additional

Published
2016
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44. HHV6-related mild encephalopathy with reversible splenial lesion (MERS) presenting with urinary and fecal retention in an Italian adolescent.

Author

Cursi L, Boccuzzi E, Lancella L, Longo D, Figá Talamanca L, Bozzola E, and Villani A

Subjects
Adolescent, Brain Diseases diagnostic imaging, Diffusion Magnetic Resonance Imaging, Female, Humans, Hyponatremia etiology, Prodromal Symptoms, Brain Diseases virology, Constipation etiology, Corpus Callosum diagnostic imaging, Herpesvirus 6, Human, Roseolovirus Infections complications, Urinary Retention etiology
Abstract

Mild encephalopathy with a reversible splenial lesion (MERS) is an uncommon clinico-radiological entity characterized by magnetic resonance imaging (MRI) findings of a reversible lesion in the splenium of corpus callosum associated with a significant neurological manifestation of encephalopathy. The majority of reported cases involve the Asiatic population and are closely associated with infection. We report the case of an adolescent with an HHV6-related MERS presenting with hyponatremia and urinary and fecal retention. To our knowledge, urinary retention is not a constant aspect of the disease and has rarely been described, while fecal retention has never been reported before. Despite the self-limiting nature of the disease, it is mandatory to suspect it for a faster diagnosis and it might be useful to know its rare occurrences in order to better understand its etiopathogenetic mechanisms.

Published
2019

45. Linezolid therapy in a perinatal late-onset Staphylococcus aureus sepsis complicated by spondylodiscitis and endophthalmitis.

Author

Krzysztofiak A, Bozzola E, Lancella L, Boccuzzi E, Vittucci AC, Marchesi A, and Villani A

Subjects
Abscess microbiology, Bacteremia complications, Bacteremia microbiology, Discitis microbiology, Endophthalmitis microbiology, Eye Enucleation, Female, Humans, Infant, Pleural Effusion drug therapy, Pneumonia, Bacterial drug therapy, Recurrence, Retinoblastoma complications, Retinoblastoma surgery, Risk Factors, Staphylococcal Infections complications, Treatment Outcome, Abscess drug therapy, Anti-Bacterial Agents therapeutic use, Bacteremia drug therapy, Discitis drug therapy, Endophthalmitis drug therapy, Linezolid therapeutic use, Staphylococcal Infections drug therapy, Staphylococcus aureus isolation & purification
Abstract

We report the case of a two-month-old immunocompetent girl affected by Staphylococcus aureus sepsis complicated with pneumonia and pleural effusion, spondylodiscitis and endophthalmitis treated with linezolid. She developed a S. aureus sepsis in the neonatal period antibiotically treated with clinical resolution. Ten days after therapy discontinuation, the infant experienced a new S. aureus sepsis complicated by pneumonia with pleural effusion. Due to the presence of dorsal swelling, a pulmonary computer tomography was performed that showed a dorsal D5-D6 spondylodiscitis. Since the sepsis was scarcely responsive to several appropriate antibiotics, we finally decided to treat the patient with linezolid. A few weeks after changing antibiotics, the child underwent an ophthalmologic visit. Due to the finding of ocular lesions, imaging examinations were performed. The diagnosis was compatible with retinoblastoma, such that the eye was enucleated. Nevertheless, histological and microbiological investigations did not confirm the tumour hypothesis, but revealed a S. aureus abscess with retinal detachment. The child completed antibiotic therapy with linezolid and was visited periodically at the Infectious Disease Unit for a follow-up. She underwent progressive resolution of discitis and did not present any further flare of sepsis. Nevertheless, she still has a replacement device in her right eye and a D5-D6 severe kyphosis with spinal fusion.

Published
2015

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