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Objective: To determine whether patients with perioperative or previous coronavirus infection (CVI) have a greater risk of venous thromboembolic events ( VTE)., Material and Methods: A multiple-center regional prospective retrospective cohort study included elective and emergency patients who underwent surgery in November 2020. The primary endpoint was VTE (PE/DVT) within 30 days after surgery. CVI was stratified as perioperative (7 days before surgery - 30 days after surgery), recent (1-6 weeks before surgery) and remote (≥7 weeks before surgery) infection. There was no information about prevention or preoperative anticoagulation at baseline data collection., Results: Incidence of postoperative VTE was 1.5% (10/650) in patients without CVI, 33.3% (3/9) in patients with perioperative CVI, 18.1% (2/11) in patients with recent CVI and 8.3% (1/12) in patients with remote CVI. After adjusting the confounders, patients with perioperative and recent CVI remained at a higher risk of VTE. In general, VTEs were independently associated with 30-day mortality. In patients with CVI, mortality rate among ones without VTE was 21.7% (5/23), with VTE - 44.4% (4/9)., Conclusion: Patients with perioperative CVI have a higher risk of postoperative VTE compared to those without CVI and patients with previous CVI and no residual symptoms. Mortality in this group is also higher than in other cohorts.

Retrospective analysis of diagnostic and curative processes in Kyiv's city centre of delivering the aid in gastrointestinal hemorrhage for 1131 patients in 1999--2003 yrs period was done. The classification of gastroduodenal erosions and an acute ulcers, complicated by hemorrhage, oriented on etiological factor involved, was proposed. Depending on etiological feature present, there were determined characteristic signs of mucosal affections, their localization and the hemorrhage severity. There was proved the expediency of introduction of the treatment results control, based on investigation of dehydrogenases activity, the intracellular glycogen content and the state of the lipids peroxidal oxidation. Clinical efficacy of synthetic analogue of somatostatin Octrestatin was studied in the treatment of gastroduodenal erosions and an acute ulcers in 26 patients. Application of Octrestatin have promoted the lipids metabolism normalization and acceleration of the mucosal ulcers healing by 2-3 days.

Two groups of patients with gastric and duodenum bleeding erosions have been treated with tradition approach (endoscopic and drug therapy) and local ozonotherapy (as for obtaining endoscopic homeostasis, so for further monotherapy). The findings obtained in two groups were compared. Endoscopic monitoring, determination of intracellular glycogen, cell metabolic characteristic and lipid peroxidation study were used to control the efficacy of the treatment and course of the disease. Ozonotherapy has proved to be more effective than traditional one as it enhances bleeding erosion healing from 7 days to 5 days with the trend of normalizing cytobiochemical blood indices.

Comparative estimation of methods of endoscopic hemostasis and treatment of an acute gastroduodenal ulcers, complicated by hemorrhage, was done: in 22 patients the conventional methods were applied, in 41-endoscopic hemostasis, using flatorization with the help of ozone-oxygen mixture and subsequent ozone insufflations. For the treatment efficacy control the endoscopic monitoring was used, there were studied cytobiochemical indexes of the dehydrogenases complex activity and of peroxide oxygenation of lipids. It was established, that ozonotherapy, even applied solely, guarantees the erosions healing in 3 days on average with simultaneous approximation to the norm of cytobiochemical indexes investigated.

Data of examination of 836 patients with an acute gastroduodenal ulcers and erosions, complicated by hemorrhage, the causes of their occurrence were analyzed. Classification, oriented toward diseases and pathological states as causal factors, was elaborated. There was established, that the location, character of affection and severity of blood loss in erosions and an acute gastroduodenal ulcers, complicated by hemorrhage, depends on causes of their occurrence. One of the main causes of the disease is the treated ulcers of stomach and duodenum.