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1. The role of childhood maltreatment and mental health disorders on suicidal behaviour in adolescents

Author

Gómez-Vallejo, S., Díaz-Marsa, M., Fernández Rodrigues, V., Andreo-Jover, J., Bobes-Bascarán, T., Cebrià, A.I., Crespo Facorro, B., Garrido-Torres, N., González-Pinto, A., Jiménez-Teviño, L., Lara, E., Lopez-Peña, M.P., Palao-Tarrero, A., Palao, D.J., Pérez, V., Ruiz-Veguilla, M., Sáiz, P.A., Sánchez-Carro, Y., de la Torre-Luque, A., Vidal Bermejo, E., Vieta, E., Zorrilla, I., Roberto, N., Grande, I., Bobes, J., Lázaro, Luisa, Bracco, Lorenzo, Corbalán, Fernando, Fares, Natalia, Ayad-Ahmed, Wala, Ayuso-Mateos, José Luis, Fernández-Fernández, Jennifer, García-Fernández, Ainoa, Garcia-Ramos, Adriana, Imaz, Carlos, Leal-Leturia, Itziar, Olivares, Luis, Payá, Beatriz, Pemau, Andres, Perez-Guerra, Carla, Seijo-Zazo, Elisa, and Tur, Nuria

Published
2025
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2. Self-reported suicidal ideation among individuals with first episode psychosis and healthy controls: Findings from the international multicentre EU-GEI study

Author

Heuschen, C.B.B.C.M., Bolhuis, K., Zantvoord, J.B., Bockting, C.L., Denys, D.A.J.P., Lok, A., Arango, C., Arrojo, M., Bernardo, M., Bobes, J., Del-Ben, C.M., Di Forti, M., Gayer-Anderson, C., Jones, P.B., Jongsma, H.E., Kirkbride, J.B., La Cascia, C., Lasalvia, A., Tosato, S., Llorca, P.M., Menezes, P.R., Murray, R.M., Quattrone, D., Rutten, B.P., Sanjuán, J., Selten, J.P., Szöke, A., Tarricone, I., Tortelli, A., Velthorst, E., de Haan, L., and Schirmbeck, F.

Published
2024
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3. The mediating role of reflective functioning in the association between childhood trauma and suicide attempt

Author

Palao-Tarrero, A., Vicente, L., Velasco, M., Orgaz, B., García, D., Vieta, E., Vázquez, M., Bracco, L., Gómez-Vallejo, S., Díaz, C., Palao, D.J., Comendador, L., Punti, J., Muñoz, M.T., García- Ramos, A., Ayad-Ahmed, W., Diaz-Carracedo, P., Ayuso-Mateos, J.L., Jimenez-Treviño, L., Bobes-Bascarán, M.T., Seijo-Zazo, E., Fernandez-Fernandez, J., Garcia-Fernandez, A., Canal-Rivero, M., Rider, J., Reguera, P., Puertas, M., García-Ligero, E., Tur, N., Navas, M., Saiz-Gonzalez, D., Carrasco, J.L., Andreo-Jover, J., Curto Ramos, J., Bobes, J., Bravo-Ortiz, M., Cebria, A.I., Crespo-Facorro, B., De la Torre-Luque, A., Díaz-Marsa, M., Fernández-Rodrigues, V., Garrido-Torres, N., Grande, I., López Peña, M.P., Pemau, A., Roberto, N., Ruiz-Veguilla, M., Saiz, P., Rodríguez-Vega, B., and Pérez-Sola, V.

Published
2024
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5. The mediating role of reflective functioning in the association between childhood trauma and suicide attempt

Author

Andreo-Jover, J., primary, Curto Ramos, J., additional, Bobes, J., additional, Bravo-Ortiz, M., additional, Cebria, A.I., additional, Crespo-Facorro, B., additional, De la Torre-Luque, A., additional, Díaz-Marsa, M., additional, Fernández-Rodrigues, V., additional, Garrido-Torres, N., additional, Grande, I., additional, López Peña, M.P., additional, Pemau, A., additional, Roberto, N., additional, Ruiz-Veguilla, M., additional, Saiz, P., additional, Rodríguez-Vega, B., additional, Pérez-Sola, V., additional, Palao-Tarrero, A., additional, Vicente, L., additional, Velasco, M., additional, Orgaz, B., additional, García, D., additional, Vieta, E., additional, Vázquez, M., additional, Bracco, L., additional, Gómez-Vallejo, S., additional, Díaz, C., additional, Palao, D.J., additional, Comendador, L., additional, Punti, J., additional, Muñoz, M.T., additional, García- Ramos, A., additional, Ayad-Ahmed, W., additional, Diaz-Carracedo, P., additional, Ayuso-Mateos, J.L., additional, Jimenez-Treviño, L., additional, Bobes-Bascarán, M.T., additional, Seijo-Zazo, E., additional, Fernandez-Fernandez, J., additional, Garcia-Fernandez, A., additional, Canal-Rivero, M., additional, Rider, J., additional, Reguera, P., additional, Puertas, M., additional, García-Ligero, E., additional, Tur, N., additional, Navas, M., additional, Saiz-Gonzalez, D., additional, and Carrasco, J.L., additional

Published
2024
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6. Self-reported suicidal ideation among individuals with first episode psychosis and healthy controls:Findings from the international multicentre EU-GEI study

Author

Heuschen, C. B.B.C.M., Bolhuis, K., Zantvoord, J. B., Bockting, C. L., Denys, D. A.J.P., Lok, A., Arango, C., Arrojo, M., Bernardo, M., Bobes, J., Del-Ben, C. M., Di Forti, M., Gayer-Anderson, C., Jones, P. B., Jongsma, H. E., Kirkbride, J. B., La Cascia, C., Lasalvia, A., Tosato, S., Llorca, P. M., Menezes, P. R., Murray, R. M., Quattrone, D., Rutten, B. P., Sanjuán, J., Selten, J. P., Szöke, A., Tarricone, I., Tortelli, A., Velthorst, E., de Haan, L., Schirmbeck, F., Heuschen, C. B.B.C.M., Bolhuis, K., Zantvoord, J. B., Bockting, C. L., Denys, D. A.J.P., Lok, A., Arango, C., Arrojo, M., Bernardo, M., Bobes, J., Del-Ben, C. M., Di Forti, M., Gayer-Anderson, C., Jones, P. B., Jongsma, H. E., Kirkbride, J. B., La Cascia, C., Lasalvia, A., Tosato, S., Llorca, P. M., Menezes, P. R., Murray, R. M., Quattrone, D., Rutten, B. P., Sanjuán, J., Selten, J. P., Szöke, A., Tarricone, I., Tortelli, A., Velthorst, E., de Haan, L., and Schirmbeck, F.

Abstract

Introduction: Suicidal ideation is common among individuals with first episode psychosis (FEP), with prevalence estimates up to 56.5 %. Despite its high prevalence, relatively little is known about how sociodemographic, clinical and/or developmental characteristics contribute to the experience of suicidal ideation in individuals with FEP. Methods: In this cross-sectional study (FEP n = 551 and controls n = 857), univariate logistic regression analyses were performed to study the associations of sociodemographic, clinical, and developmental factors with suicidal ideation in individuals with FEP as well as controls. Suicidal ideation was assessed using the Community Assessment of Psychic Experiences (CAPE). In addition, multivariate logistic regression analyses were conducted based on a stepwise approach. Results: In FEP, only depressive symptoms remained significantly associated with suicidal ideation when all correlates were integrated into one model. In the multivariate model in controls, depressive symptoms, positive symptoms, and traumatic childhood experiences were significantly associated with suicidal ideation. Conclusions: This study showed that depressive symptoms are an important factor relating to suicidal ideation in individuals with FEP, over and above other clinical, sociodemographic, and developmental factors. This underscores the relevance of screening for suicidal ideation in individuals with FEP, and highlights the need for a better understanding of the diagnostic uncertainty and course of mood symptoms in early psychosis. Limitations: Cross-sectional study design, self-reported questionnaires.

Published
2024

9. Updated European Consensus Statement on diagnosis and treatment of adult ADHD

Author

Kooij, J.J.S., Bijlenga, D., Salerno, L., Jaeschke, R., Bitter, I., Balázs, J., Thome, J., Dom, G., Kasper, S., Nunes Filipe, C., Stes, S., Mohr, P., Leppämäki, S., Casas, M., Bobes, J., Mccarthy, J.M., Richarte, V., Kjems Philipsen, A., Pehlivanidis, A., Niemela, A., Styr, B., Semerci, B., Bolea-Alamanac, B., Edvinsson, D., Baeyens, D., Wynchank, D., Sobanski, E., Philipsen, A., McNicholas, F., Caci, H., Mihailescu, I., Manor, I., Dobrescu, I., Saito, T., Krause, J., Fayyad, J., Ramos-Quiroga, J.A., Foeken, K., Rad, F., Adamou, M., Ohlmeier, M., Fitzgerald, M., Gill, M., Lensing, M., Motavalli Mukaddes, N., Brudkiewicz, P., Gustafsson, P., Tani, P., Oswald, P., Carpentier, P.J., De Rossi, P., Delorme, R., Markovska Simoska, S., Pallanti, S., Young, S., Bejerot, S., Lehtonen, T., Kustow, J., Müller-Sedgwick, U., Hirvikoski, T., Pironti, V., Ginsberg, Y., Félegyházy, Z., Garcia-Portilla, M.P., and Asherson, P.

Published
2019
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10. DNA methylation patterns associated with suicide attempts in bipolar disorder

Author

Acosta, M., primary, Mitjans, M., additional, Zafrilla, M., additional, Giménez-Palomo, A., additional, Saiz, P.A., additional, Barrot, C., additional, Jiménez, E., additional, Papiol, S., additional, Ruiz, V., additional, Gavín, P., additional, García-Portilla, M.P., additional, González-Blanco, L., additional, Bobes, J., additional, Schulze, T.G., additional, Vieta, E., additional, Benabarre, A., additional, and Arias, B., additional

Published
2024
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11. Prediction models for suicidal behaviour in a cohort of Spanish suicide attempters

Author

Herrero, N. Roberto, primary, Prisco, M., additional, Oliva, V., additional, Pérez-Solà, V., additional, Elices, M., additional, Toll-Privat, A., additional, Bobes, J., additional, López-Peña, P., additional, Ruiz-Veguilla, M., additional, Ángela, P., additional, Annabel, C., additional, De la Torre-Luque, A., additional, Díaz-Marsà, M., additional, and Grande, I., additional

Published
2024
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12. The impact of methylation patterns and epigenetic aging in lithium response

Author

López, M. Zafrilla, primary, Acosta-Díez, M., additional, Giménez-Palomo, A., additional, Saiz, P.A., additional, Barrot-Feixat, C., additional, Jiménez, E., additional, Papiol, S., additional, Ruiz, V., additional, Gavín, P., additional, García-Portilla, M.P., additional, González-Blanco, L., additional, Bobes, J., additional, Schulze, T.G., additional, Vieta, E., additional, Benabarre, A., additional, Mitjans, M., additional, and Arias, B., additional

Published
2024
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17. Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings

Author

Velthorst E., Mollon J., Murray R. M., de Haan L., Germeys I. M., Glahn D. C., Arango C., van der Ven E., Di Forti M., Bernardo M., Guloksuz S., Delespaul P., Mezquida G., Amoretti S., Bobes J., Saiz P. A., Garcia-Portilla M. P., Santos J. L., Jimenez-Lopez E., Sanjuan J., Aguilar E. J., Arrojo M., Carracedo A., Lopez G., Gonzalez-Penas J., Parellada M., Atbasoglu C., Saka M. C., Ucok A., Alptekin K., Akdede B., Binbay T., Altinyazar V., Ulas H., Yalincetin B., Gumus-Akay G., Beyaz B. C., Soygur H., Cankurtaran E. S., Kaymak S. U., Maric N. P., Mihaljevic M. M., Petrovic S. A., Mirjanic T., Del-Ben C. M., Ferraro L., Gayer-Anderson C., Jones P. B., Jongsma H. E., Kirkbride J. B., La Cascia C., Lasalvia A., Tosato S., Llorca P. -M., Menezes P. R., Morgan C., Quattrone D., Menchetti M., Selten J. -P., Szoke A., Tarricone I., Tortelli A., McGuire P., Valmaggia L., Kempton M. J., van der Gaag M., Riecher-Rossler A., Bressan R. A., Barrantes-Vidal N., Nelson B., McGorry P., Pantelis C., Krebs M. -O., Ruhrmann S., Sachs G., Rutten B. P. F., van Os J., Alizadeh B. Z., van Amelsvoort T., Bartels-Velthuis A. A., Bruggeman R., van Beveren N. J., Luykx J. J., Cahn W., Simons C. J. P., Kahn R. S., Schirmbeck F., van Winkel R., Calem M., Tognin S., Modinos G., Pisani S., Kraan T. C., van Dam D. S., Burger N., Amminger G. P., Politis A., Goodall J., Borgwardt S., Studerus E., Gadelha A., Brietzke E., Asevedo G., Asevedo E., Zugman A., Dominguez-Martinez T., Monsonet M., Cristobal-Narvaez P., Racioppi A., Kwapil T. R., Kazes M., Daban C., Bourgin J., Gay O., Mam-Lam-Fook C., Nordholm D., Rander L., Krakauer K., Glenthoj L. B., Glenthoj B., Gebhard D., Arnhold J., Klosterkotter J., Lasser I., Winklbaur B., Reichenberg A., Velthorst E., Mollon J., Murray R.M., de Haan L., Germeys I.M., Glahn D.C., Arango C., van der Ven E., Di Forti M., Bernardo M., Guloksuz S., Delespaul P., Mezquida G., Amoretti S., Bobes J., Saiz P.A., Garcia-Portilla M.P., Santos J.L., Jimenez-Lopez E., Sanjuan J., Aguilar E.J., Arrojo M., Carracedo A., Lopez G., Gonzalez-Penas J., Parellada M., Atbasoglu C., Saka M.C., Ucok A., Alptekin K., Akdede B., Binbay T., Altinyazar V., Ulas H., Yalincetin B., Gumus-Akay G., Beyaz B.C., Soygur H., Cankurtaran E.S., Kaymak S.U., Maric N.P., Mihaljevic M.M., Petrovic S.A., Mirjanic T., Del-Ben C.M., Ferraro L., Gayer-Anderson C., Jones P.B., Jongsma H.E., Kirkbride J.B., La Cascia C., Lasalvia A., Tosato S., Llorca P.-M., Menezes P.R., Morgan C., Quattrone D., Menchetti M., Selten J.-P., Szoke A., Tarricone I., Tortelli A., McGuire P., Valmaggia L., Kempton M.J., van der Gaag M., Riecher-Rossler A., Bressan R.A., Barrantes-Vidal N., Nelson B., McGorry P., Pantelis C., Krebs M.-O., Ruhrmann S., Sachs G., Rutten B.P.F., van Os J., Alizadeh B.Z., van Amelsvoort T., Bartels-Velthuis A.A., Bruggeman R., van Beveren N.J., Luykx J.J., Cahn W., Simons C.J.P., Kahn R.S., Schirmbeck F., van Winkel R., Calem M., Tognin S., Modinos G., Pisani S., Kraan T.C., van Dam D.S., Burger N., Amminger G.P., Politis A., Goodall J., Borgwardt S., Studerus E., Gadelha A., Brietzke E., Asevedo G., Asevedo E., Zugman A., Dominguez-Martinez T., Monsonet M., Cristobal-Narvaez P., Racioppi A., Kwapil T.R., Kazes M., Daban C., Bourgin J., Gay O., Mam-Lam-Fook C., Nordholm D., Rander L., Krakauer K., Glenthoj L.B., Glenthoj B., Gebhard D., Arnhold J., Klosterkotter J., Lasser I., Winklbaur B., Reichenberg A., RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Neurosciences, Psychiatry, Clinical Developmental Psychology, World Health Organization (WHO) Collaborating Center, Life Course Epidemiology (LCE), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, and Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep

Subjects
0301 basic medicine, validity, medicine.medical_treatment, CHILDHOOD, Neuropsychological Tests, FAMÍLIA, episode, Cognition, 0302 clinical medicine, DEFICITS, Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat, Medicine, Cognitive impairment, Psychiatry, Symptom severity, Cannabis use, IMPAIRMENT, ABILITY, Psychiatry and Mental health, Schizophrenia, RELIABILITY, Neuropsychological Test, Life Sciences & Biomedicine, Human, Clinical psychology, Adult, Biochemistry & Molecular Biology, impairment, schizophrenia-patients, ability, GENETIC RISK, Psychotic Disorder, SCHIZOPHRENIA-PATIENTS, 03 medical and health sciences, Cellular and Molecular Neuroscience, SDG 3 - Good Health and Well-being, Settore M-PSI/08 - Psicologia Clinica, Humans, In patient, Cognitive skill, VALIDITY, Antipsychotic, Molecular Biology, Settore MED/25 - Psichiatria, Aged, Cross-Sectional Studie, DECLINE, Science & Technology, reliability, business.industry, Working memory, Siblings, Neurosciences, Diagnostic markers, medicine.disease, Cross-Sectional Studies, 030104 developmental biology, deficits, Psychotic Disorders, PSYCHOSIS, COGNITION, MULTICENTRIC STUDY, Neurosciences & Neurology, business, EPISODE, 030217 neurology & neurosurgery
Abstract

The European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (EUGEI); The Spanish sample was supported by the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/024) (...), Velthorst, E., Mollon, J., Murray, R.M., de Haan, L., Germeys, I.M., Glahn, D.C., Arango, C., van der Ven, E., Di Forti, M., Bernardo, M., Guloksuz, S., Delespaul, P., Mezquida, G., Amoretti, S., Bobes, J., Saiz, P.A., García-Portilla, M.P., Santos, J.L., Jiménez-López, E., Sanjuan, J., Aguilar, E.J., Arrojo, M., Carracedo, A., López, G., González-Peñas, J., Parellada, M., Atbaşoğlu, C., Saka, M.C., Üçok, A., Alptekin, K., Akdede, B., Binbay, T., Altınyazar, V., Ulaş, H., Yalınçetin, B., Gümüş-Akay, G., Beyaz, B.C., Soygür, H., Cankurtaran, E.Ş., Kaymak, S.U., Maric, N.P., Mihaljevic, M.M., Petrovic, S.A., Mirjanic, T., Del-Ben, C.M., Ferraro, L., Gayer-Anderson, C., Jones, P.B., Jongsma, H.E., Kirkbride, J.B., La Cascia, C., Lasalvia, A., Tosato, S., Llorca, P.-M., Menezes, P.R., Morgan, C., Quattrone, D., Menchetti, M., Selten, J.-P., Szöke, A., Tarricone, I., Tortelli, A., McGuire, P., Valmaggia, L., Kempton, M.J., van der Gaag, M., Riecher-Rössler, A., Bressan, R.A., Barrantes-Vidal, N., Nelson, B., McGorry, P., Pantelis, C., Krebs, M.-O., Ruhrmann, S., Sachs, G., Rutten, B.P.F., van Os, J., Alizadeh, B.Z., van Amelsvoort, T., Bartels-Velthuis, A.A., Bruggeman, R., van Beveren, N.J., Luykx, J.J., Cahn, W., Simons, C.J.P., Kahn, R.S., Schirmbeck, F., van Winkel, R., Calem, M., Tognin, S., Modinos, G., Pisani, S., Kraan, T.C., van Dam, D.S., Burger, N., Amminger, G.P., Politis, A., Goodall, J., Borgwardt, S., Studerus, E., Gadelha, A., Brietzke, E., Asevedo, G., Asevedo, E., Zugman, A., Domínguez-Martínez, T., Monsonet, M., Cristóbal-Narváez, P., Racioppi, A., Kwapil, T.R., Kazes, M., Daban, C., Bourgin, J., Gay, O., Mam-Lam-Fook, C., Nordholm, D., Rander, L., Krakauer, K., Glenthøj, L.B., Glenthøj, B., Gebhard, D., Arnhold, J., Klosterkötter, J., Lasser, I., Winklbaur, B., Reichenberg, A., EU-GEI High Risk Study

Published
2021
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18. Common genetic variants contribute to heritability of age at onset of schizophrenia

Author

Universitat Rovira i Virgili, Sada-Fuente, E; Aranda, S; Papiol, S; Heilbronner, U; Moltó, MD; Aguilar, EJ; González-Peñas, J; Andreu-Bernabeu, A; Arango, C; Crespo-Facorro, B; González-Pinto, A; Fañanás, L; Arias, B; Bobes, J; Costas, J; Martorell, L; Schulze, TG; Kalman, JL; Vilella, E; Muntané, G, Universitat Rovira i Virgili, and Sada-Fuente, E; Aranda, S; Papiol, S; Heilbronner, U; Moltó, MD; Aguilar, EJ; González-Peñas, J; Andreu-Bernabeu, A; Arango, C; Crespo-Facorro, B; González-Pinto, A; Fañanás, L; Arias, B; Bobes, J; Costas, J; Martorell, L; Schulze, TG; Kalman, JL; Vilella, E; Muntané, G

Abstract

Schizophrenia (SCZ) is a complex disorder that typically arises in late adolescence or early adulthood. Age at onset (AAO) of SCZ is associated with long-term outcomes of the disease. We explored the genetic architecture of AAO with a genome-wide association study (GWAS), heritability, polygenic risk score (PRS), and copy number variant (CNV) analyses in 4 740 subjects of European ancestry. Although no genome-wide significant locus was identified, SNP-based heritability of AAO was estimated to be between 17 and 21%, indicating a moderate contribution of common variants. We also performed cross-trait PRS analyses with a set of mental disorders and identified a negative association between AAO and common variants for SCZ, childhood maltreatment and attention-deficit/hyperactivity disorder. We also investigated the role of copy number variants (CNVs) in AAO and found an association with the length and number of deletions (P-value = 0.03), whereas the presence of CNVs previously reported in SCZ was not associated with earlier onset. To our knowledge, this is the largest GWAS of AAO of SCZ to date in individuals from European ancestry, and the first study to determine the involvement of common variants in the heritability of AAO. Finally, we evidenced the role played by higher SCZ load in determining AAO but discarded the role of pathogenic CNVs. Altogether, these results shed light on the genetic architecture of AAO, which needs to be confirmed with larger studies.© 2023. The Author(s).

Published
2023

19. Tobacco use in first-episode psychosis, a multinational EU-GEI study.

Author

Sánchez-Gutiérrez, T., Rodríguez-Toscano, E., Roldán, L., Ferraro, L., Parellada, M., Calvo, A., López, G., Rapado-Castro, M., La Barbera, D., La Cascia, C., Tripoli, G., Di Forti, M., Murray, R. M., Quattrone, D., Morgan, C., van Os, J., García-Portilla, P., Al-Halabí, S., Bobes, J., and de Haan, L.

Subjects
DIAGNOSIS of schizophrenia, CANNABIS (Genus), CONFIDENCE intervals, PSYCHOSES, REGRESSION analysis, AGE factors in disease, QUESTIONNAIRES, ALCOHOL drinking, DESCRIPTIVE statistics, RESEARCH funding, SMOKING, TOBACCO products, SOCIODEMOGRAPHIC factors, ODDS ratio
Abstract

Background: Tobacco is a highly prevalent substance of abuse in patients with psychosis. Previous studies have reported an association between tobacco use and schizophrenia. The aim of this study was to analyze the relationship between tobacco use and first-episode psychosis (FEP), age at onset of psychosis, and specific diagnosis of psychosis. Methods: The sample consisted of 1105 FEP patients and 1355 controls from the European Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI) study. We assessed substance use with the Tobacco and Alcohol Questionnaire and performed a series of regression analyses using case-control status, age of onset of psychosis, and diagnosis as outcomes and tobacco use and frequency of tobacco use as predictors. Analyses were adjusted for sociodemographic characteristics, alcohol, and cannabis use. Results: After controlling for cannabis use, FEP patients were 2.6 times more likely to use tobacco [ p ⩽ 0.001; adjusted odds ratio (AOR) 2.6; 95% confidence interval (CI) [2.1–3.2]] and 1.7 times more likely to smoke 20 or more cigarettes a day (p = 0.003; AOR 1.7; 95% CI [1.2–2.4]) than controls. Tobacco use was associated with an earlier age at psychosis onset (β = −2.3; p ⩽ 0.001; 95% CI [−3.7 to −0.9]) and was 1.3 times more frequent in FEP patients with a diagnosis of schizophrenia than in other diagnoses of psychosis (AOR 1.3; 95% CI [1.0–1.8]); however, these results were no longer significant after controlling for cannabis use. Conclusions: Tobacco and heavy-tobacco use are associated with increased odds of FEP. These findings further support the relevance of tobacco prevention in young populations. [ABSTRACT FROM AUTHOR]

Published
2023
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23. The response to unfolded proteins in schizophrenia and bipolar disorder

Author

Cachán, C., primary, Valle, I. M., additional, Potes, Y., additional, González Rubio, A., additional, Menéndez Coto, N., additional, López Fanjul, D., additional, Vega Naredo, I., additional, Caballero, B., additional, Saiz, P., additional, Bobes, J., additional, García Portilla, P., additional, and Coto Montes, A., additional

Published
2023
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26. Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study

Author

Trotta, G, Rodriguez, V, Quattrone, D, Spinazzola, E, Tripoli, G, Gayer-Anderson, C, Freeman, Tp, Jongsma, He, Sideli, L, Aas, M, Stilo, Sa, La Cascia, C, Ferraro, L, La Barbera, D, Lasalvia, A, Tosato, S, Tarricone, I, D'Andrea, G, Tortelli, A, Schurhoff, F, Szoke, A, Pignon, B, Selten, Jp, Velthorst, E, de Haan, L, Llorca, Pm, Menezes, Pr, Del Ben, Cm, Santos, Jl, Arrojo, M, Bobes, J, Sanjuan, J, Bernardo, M, Arango, C, Kirkbride, Jb, Jones, Pb, Richards, A, Rutten, Bp, Van Os, J, Austin-Zimmerman, I, Zk, Li, Morgan, C, Sham, Pc, Vassos, E, Wong, C, Bentall, R, Fisher, Hl, Murray, Rm, Alameda, L, and Di Forti, M

Subjects
trauma, psychotic disorders, childhood experience, mediation, Cannabis use
Published
2023

28. Lithium response in patients with bipolar disorder: analysing the role of methylation patterns and epigenetic aging

Author

López, M. Zafrilla, primary, Acosta, M., additional, Giménez-Palomo, A., additional, Sáiz, P.A., additional, Barrot, C., additional, Jiménez, E., additional, Papiol, S., additional, Ruíz, V., additional, Gavín, P., additional, García-Portilla, M.P., additional, González-Blanco, L., additional, Bobes, J., additional, Schulze, T.G., additional, Vieta, E., additional, Benabarre, A., additional, Mitjans, M., additional, and Arias, B., additional

Published
2023
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29. Epigenetic aging in bipolar patients with suicide attempts or childhood maltreatment

Author

Acosta, M., primary, Prat-Esquerdo, M., additional, Zafrilla, M., additional, Giménez-Palomo, A., additional, Saiz, P.A., additional, Barrot, C., additional, Jiménez, E., additional, Papiol, S., additional, Ruiz, V., additional, Gavín, P., additional, García-Portilla, M.P., additional, González-Blanco, L., additional, Bobes, J., additional, Schulze, T.G., additional, Vieta, E., additional, Benabarre, A., additional, Arias, B., additional, and Mitjans, M., additional

Published
2023
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33. Corrigendum to “Spanish validation of the Barcelona TEMPS-A questionnaire in patients with bipolar disorder and general population” [J. Affect. Disord. 249 (2019) 199–207 (Apr 15)]

Author

Jiménez, E., primary, Bonnín, C.D.M., additional, Solé, B., additional, Sánchez-Moreno, J., additional, Reinares, M., additional, Torrent, C., additional, Torres, I., additional, Salagre, E., additional, Varo, C., additional, Ruíz, V., additional, Giménez, A., additional, Benabarre, A., additional, Gutiérrez-Rojas, L., additional, Cervilla, J., additional, Sáiz, P.A., additional, García-Portilla, M.P., additional, Bobes, J., additional, Amann, B.L., additional, Martínez-Arán, A., additional, and Vieta, E., additional

Published
2022
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39. Orexins and bipolar disorder: A review

Author

Moya Lacasa, C., primary, Gonzalez-Blanco, L., additional, Martinez-Cao, C., additional, Alvarez-Vazquez, C.M., additional, Martin-Gil, E., additional, García Fernández, A., additional, Saiz, P.A., additional, Bobes, J., additional, and Garcia-Portilla, M.P., additional

Published
2022
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42. Results of the COVID-19 mental health international for the general population (COMET-G) study

Author

Fountoulakis, KN, Karakatsoulis, G, Abraham, S, Adorjan, K, Ahmed, HU, Alarcón, RD, Arai, K, Auwal, SS, Berk, Michael, Bjedov, S, Bobes, J, Bobes-Bascaran, T, Bourgin-Duchesnay, J, Bredicean, CA, Bukelskis, L, Burkadze, A, Abud, IIC, Castilla-Puentes, R, Cetkovich, M, Colon-Rivera, H, Corral, R, Cortez-Vergara, C, Crepin, P, De Berardis, D, Zamora Delgado, S, De Lucena, D, De Sousa, A, Stefano, RD, Dodd, Seetal, Elek, LP, Elissa, A, Erdelyi-Hamza, B, Erzin, G, Etchevers, MJ, Falkai, P, Farcas, A, Fedotov, I, Filatova, V, Fountoulakis, NK, Frankova, I, Franza, F, Frias, P, Galako, T, Garay, CJ, Garcia-Álvarez, L, García-Portilla, MP, Gonda, X, Gondek, TM, González, DM, Gould, H, Grandinetti, P, Grau, A, Groudeva, V, Hagin, M, Harada, T, Hasan, TM, Hashim, NA, Hilbig, J, Hossain, S, Iakimova, R, Ibrahim, M, Iftene, F, Ignatenko, Y, Irarrazaval, M, Ismail, Z, Ismayilova, J, Jakobs, A, Jakovljević, M, Jakšić, N, Javed, A, Kafali, HY, Karia, S, Kazakova, O, Khalifa, D, Khaustova, O, Koh, S, Kopishinskaia, S, Kosenko, K, Koupidis, SA, Kovacs, I, Kulig, B, Lalljee, A, Liewig, J, Majid, A, Malashonkova, E, Malik, K, Malik, NI, Mammadzada, G, Mandalia, B, Marazziti, D, Marčinko, D, Martinez, S, Matiekus, E, Mejia, G, Memon, RS, Martínez, XEM, Mickevičiūtė, D, Milev, R, Mohammed, M, Molina-López, A, Fountoulakis, KN, Karakatsoulis, G, Abraham, S, Adorjan, K, Ahmed, HU, Alarcón, RD, Arai, K, Auwal, SS, Berk, Michael, Bjedov, S, Bobes, J, Bobes-Bascaran, T, Bourgin-Duchesnay, J, Bredicean, CA, Bukelskis, L, Burkadze, A, Abud, IIC, Castilla-Puentes, R, Cetkovich, M, Colon-Rivera, H, Corral, R, Cortez-Vergara, C, Crepin, P, De Berardis, D, Zamora Delgado, S, De Lucena, D, De Sousa, A, Stefano, RD, Dodd, Seetal, Elek, LP, Elissa, A, Erdelyi-Hamza, B, Erzin, G, Etchevers, MJ, Falkai, P, Farcas, A, Fedotov, I, Filatova, V, Fountoulakis, NK, Frankova, I, Franza, F, Frias, P, Galako, T, Garay, CJ, Garcia-Álvarez, L, García-Portilla, MP, Gonda, X, Gondek, TM, González, DM, Gould, H, Grandinetti, P, Grau, A, Groudeva, V, Hagin, M, Harada, T, Hasan, TM, Hashim, NA, Hilbig, J, Hossain, S, Iakimova, R, Ibrahim, M, Iftene, F, Ignatenko, Y, Irarrazaval, M, Ismail, Z, Ismayilova, J, Jakobs, A, Jakovljević, M, Jakšić, N, Javed, A, Kafali, HY, Karia, S, Kazakova, O, Khalifa, D, Khaustova, O, Koh, S, Kopishinskaia, S, Kosenko, K, Koupidis, SA, Kovacs, I, Kulig, B, Lalljee, A, Liewig, J, Majid, A, Malashonkova, E, Malik, K, Malik, NI, Mammadzada, G, Mandalia, B, Marazziti, D, Marčinko, D, Martinez, S, Matiekus, E, Mejia, G, Memon, RS, Martínez, XEM, Mickevičiūtė, D, Milev, R, Mohammed, M, and Molina-López, A

Published
2022

43. Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway

Author

van Os, J., van Os, J., Pries, L.K., ten Have, M., de Graaf, R., van Dorsselaer, S., Delespaul, P., Bak, M., Kenis, G., Lin, B.D., Luykx, J.J., Richards, A.L., Akdede, B., Binbay, T., Altinyazar, V., Yalincetin, B., Gumus-Akay, G., Cihan, B., Soygur, H., Ulas, H., Cankurtaran, E.S., Kaymak, S.U., Mihaljevic, M.M., Petrovic, S.A., Mirjanic, T., Bernardo, M., Mezquida, G., Amoretti, S., Bobes, J., Saiz, P.A., Garcia-Portilla, M.P., Sanjuan, J., Aguilar, E.J., Santos, J.L., Jimenez-Lopez, E., Arrojo, M., Carracedo, A., Lopez, G., Gonzalez-Penas, J., Parellada, M., Maric, N.P., Atbasoglu, C., Ucok, A., Alptekin, K., Saka, M.C., Arango, C., O'Donovan, M., Rutten, B.P.F., Guloksuz, S., van Os, J., van Os, J., Pries, L.K., ten Have, M., de Graaf, R., van Dorsselaer, S., Delespaul, P., Bak, M., Kenis, G., Lin, B.D., Luykx, J.J., Richards, A.L., Akdede, B., Binbay, T., Altinyazar, V., Yalincetin, B., Gumus-Akay, G., Cihan, B., Soygur, H., Ulas, H., Cankurtaran, E.S., Kaymak, S.U., Mihaljevic, M.M., Petrovic, S.A., Mirjanic, T., Bernardo, M., Mezquida, G., Amoretti, S., Bobes, J., Saiz, P.A., Garcia-Portilla, M.P., Sanjuan, J., Aguilar, E.J., Santos, J.L., Jimenez-Lopez, E., Arrojo, M., Carracedo, A., Lopez, G., Gonzalez-Penas, J., Parellada, M., Maric, N.P., Atbasoglu, C., Ucok, A., Alptekin, K., Saka, M.C., Arango, C., O'Donovan, M., Rutten, B.P.F., and Guloksuz, S.

Abstract

Background There is evidence that environmental and genetic risk factors for schizophrenia spectrum disorders are transdiagnostic and mediated in part through a generic pathway of affective dysregulation. Methods We analysed to what degree the impact of schizophrenia polygenic risk (PRS-SZ) and childhood adversity (CA) on psychosis outcomes was contingent on co-presence of affective dysregulation, defined as significant depressive symptoms, in (i) NEMESIS-2 (n = 6646), a representative general population sample, interviewed four times over nine years and (ii) EUGEI (n = 4068) a sample of patients with schizophrenia spectrum disorder, the siblings of these patients and controls. Results The impact of PRS-SZ on psychosis showed significant dependence on co-presence of affective dysregulation in NEMESIS-2 [relative excess risk due to interaction (RERI): 1.01, p = 0.037] and in EUGEI (RERI = 3.39, p = 0.048). This was particularly evident for delusional ideation (NEMESIS-2: RERI = 1.74, p = 0.003; EUGEI: RERI = 4.16, p = 0.019) and not for hallucinatory experiences (NEMESIS-2: RERI = 0.65, p = 0.284; EUGEI: -0.37, p = 0.547). A similar and stronger pattern of results was evident for CA (RERI delusions and hallucinations: NEMESIS-2: 3.02, p < 0.001; EUGEI: 6.44, p < 0.001; RERI delusional ideation: NEMESIS-2: 3.79, p < 0.001; EUGEI: 5.43, p = 0.001; RERI hallucinatory experiences: NEMESIS-2: 2.46, p < 0.001; EUGEI: 0.54, p = 0.465). Conclusions The results, and internal replication, suggest that the effects of known genetic and non-genetic risk factors for psychosis are mediated in part through an affective pathway, from which early states of delusional meaning may arise.

Published
2022

44. Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis: findings from the multinational EU-GEI study

Author

Hersenen-Medisch 1, Brain, Pignon, B, Peyre, H, Ayrolles, A, Kirkbride, J B, Jamain, S, Ferchiou, A, Richard, J R, Baudin, G, Tosato, S, Jongsma, H, de Haan, L, Tarricone, I, Bernardo, M, Velthorst, E, Braca, M, Arango, C, Arrojo, M, Bobes, J, Del-Ben, C M, Di Forti, M, Gayer-Anderson, C, Jones, P B, La Cascia, C, Lasalvia, A, Menezes, P R, Quattrone, D, Sanjuán, J, Selten, J P, Tortelli, A, Llorca, P M, van Os, J, Rutten, B P F, Murray, R M, Morgan, C, Leboyer, M, Szöke, A, Schürhoff, F, Hersenen-Medisch 1, Brain, Pignon, B, Peyre, H, Ayrolles, A, Kirkbride, J B, Jamain, S, Ferchiou, A, Richard, J R, Baudin, G, Tosato, S, Jongsma, H, de Haan, L, Tarricone, I, Bernardo, M, Velthorst, E, Braca, M, Arango, C, Arrojo, M, Bobes, J, Del-Ben, C M, Di Forti, M, Gayer-Anderson, C, Jones, P B, La Cascia, C, Lasalvia, A, Menezes, P R, Quattrone, D, Sanjuán, J, Selten, J P, Tortelli, A, Llorca, P M, van Os, J, Rutten, B P F, Murray, R M, Morgan, C, Leboyer, M, Szöke, A, and Schürhoff, F

Published
2022

45. Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia

Author

Universitat Rovira i Virgili, Andreu-Bernabeu Á; Díaz-Caneja CM; Costas J; De Hoyos L; Stella C; Gurriarán X; Alloza C; Fañanás L; Bobes J; González-Pinto A; Crespo-Facorro B; Martorell L; Vilella E; Muntané G; Nacher J; Molto MD; Aguilar EJ; Parellada M; Arango C; González-Peñas J, Universitat Rovira i Virgili, and Andreu-Bernabeu Á; Díaz-Caneja CM; Costas J; De Hoyos L; Stella C; Gurriarán X; Alloza C; Fañanás L; Bobes J; González-Pinto A; Crespo-Facorro B; Martorell L; Vilella E; Muntané G; Nacher J; Molto MD; Aguilar EJ; Parellada M; Arango C; González-Peñas J

Abstract

Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control sample (N = 3,488). We then subset schizophrenia predisposing variation based on its effect on LNL-ISO. We find that genetic variation with concordant effects in both phenotypes shows significant SNP-based heritability enrichment, higher polygenic contribution in females, and positive covariance with mental disorders such as depression, anxiety, attention-deficit hyperactivity disorder, alcohol dependence, and autism. Conversely, genetic variation with discordant effects only contributes to schizophrenia risk in males and is negatively correlated with those disorders. Mendelian randomization analyses demonstrate a plausible bi-directional causal relationship between LNL-ISO and schizophrenia, with a greater effect of LNL-ISO liability on schizophrenia than vice versa. These results illustrate the genetic footprint of LNL-ISO on schizophrenia.© 2022. The Author(s).

Published
2022

46. Differences in patterns of stimulant use and their impact on first-episode psychosis incidence – an analysis of the EUGEI study

Author

Rodríguez-Toscano, E., Alloza, C., Fraguas, D., Durán-Cutilla, M., Roldán, L., Gutiérrez, T. Sánchez, López-Montoya, G., Parellada, M., Moreno, C., Gayer-Anderson, C., Jongsma, H.E., Di Forti, M., Velthorst, E., de Haan, L., Selten, J., Szöke, A., Llorca, P., Tortelli, A., Bobes, J., Tarricone, I., Berardi, D., Ruggeri, M., Lasalvia, A., Ferraro, L., Menezes, P.R., Rutten, B.P., Van Os, J., Jones, P.B., Murray, R.M., Kirkbride, J.B., Morgan, C., Díaz-Caneja, C.M., and Arango, C.

Published
2022
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