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1. Treatment Outcomes of Adolescents Compared to Younger Pediatric Patients with Acute Myeloid Leukemia: Do They Need a Special Approach?

Author

Pawińska-Wąsikowska, Katarzyna, primary, Czogała, Małgorzata, additional, Bukowska-Strakova, Karolina, additional, Surman, Marta, additional, Rygielska, Monika, additional, Książek, Teofila, additional, Sadowska, Beata, additional, Pac, Agnieszka, additional, Skalska-Sadowska, Jolanta, additional, Samborska, Magdalena, additional, Wachowiak, Jacek, additional, Ciebiera, Małgorzata, additional, Chaber, Radosław, additional, Tomaszewska, Renata, additional, Szczepański, Tomasz, additional, Zielezińska, Karolina, additional, Urasiński, Tomasz, additional, Moj-Hackemer, Małgorzata, additional, Kałwak, Krzysztof, additional, Kozłowska, Marta, additional, Irga-Jaworska, Ninela, additional, Sikorska-Fic, Barbara, additional, Łaguna, Paweł, additional, Muszyńska-Rosłan, Katarzyna, additional, Krawczuk-Rybak, Maryna, additional, Fałkowska, Anna, additional, Drabko, Katarzyna, additional, Bobeff, Katarzyna, additional, Młynarski, Wojciech, additional, Chodała-Grzywacz, Agnieszka, additional, Karolczyk, Grażyna, additional, Mycko, Katarzyna, additional, Badowska, Wanda, additional, Bartoszewicz, Natalia, additional, Styczyński, Jan, additional, Machnik, Katarzyna, additional, Mizia-Malarz, Agnieszka, additional, Balwierz, Walentyna, additional, and Skoczeń, Szymon, additional

Published
2024
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3. Anti-PD-1 Therapy in Advanced Pediatric Malignancies in Nationwide Study: Good Outcome in Skin Melanoma and Hodgkin Lymphoma

Author

Marjańska, Agata, primary, Pawińska-Wąsikowska, Katarzyna, additional, Wieczorek, Aleksandra, additional, Drogosiewicz, Monika, additional, Dembowska-Bagińska, Bożenna, additional, Bobeff, Katarzyna, additional, Młynarski, Wojciech, additional, Adamczewska-Wawrzynowicz, Katarzyna, additional, Wachowiak, Jacek, additional, Krawczyk, Małgorzata A., additional, Irga-Jaworska, Ninela, additional, Węcławek-Tompol, Jadwiga, additional, Kałwak, Krzysztof, additional, Sawicka-Żukowska, Małgorzata, additional, Krawczuk-Rybak, Maryna, additional, Raciborska, Anna, additional, Mizia-Malarz, Agnieszka, additional, Sobocińska-Mirska, Agata, additional, Łaguna, Paweł, additional, Balwierz, Walentyna, additional, and Styczyński, Jan, additional

Published
2024
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4. Characteristics and Outcome of FLT3-ITD-Positive Pediatric Acute Myeloid Leukemia—Experience of Polish Pediatric Leukemia and Lymphoma Study Group from 2005 to 2022

Author

Czogała, Małgorzata, primary, Czogała, Wojciech, additional, Pawińska-Wąsikowska, Katarzyna, additional, Książek, Teofila, additional, Bukowska-Strakova, Karolina, additional, Sikorska-Fic, Barbara, additional, Łaguna, Paweł, additional, Fałkowska, Anna, additional, Drabko, Katarzyna, additional, Muszyńska-Rosłan, Katarzyna, additional, Krawczuk-Rybak, Maryna, additional, Kozłowska, Marta, additional, Irga-Jaworska, Ninela, additional, Zielezińska, Karolina, additional, Urasiński, Tomasz, additional, Bartoszewicz, Natalia, additional, Styczyński, Jan, additional, Skalska-Sadowska, Jolanta, additional, Wachowiak, Jacek, additional, Rodziewicz-Konarska, Anna, additional, Kałwak, Krzysztof, additional, Ciebiera, Małgorzata, additional, Chaber, Radosław, additional, Mizia-Malarz, Agnieszka, additional, Chodała-Grzywacz, Agnieszka, additional, Karolczyk, Grażyna, additional, Bobeff, Katarzyna, additional, Młynarski, Wojciech, additional, Mycko, Katarzyna, additional, Badowska, Wanda, additional, Tomaszewska, Renata, additional, Szczepański, Tomasz, additional, Machnik, Katarzyna, additional, Zamorska, Natalia, additional, Balwierz, Walentyna, additional, and Skoczeń, Szymon, additional

Published
2023
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7. Venetoclax Use in Paediatric Haemato-Oncology Centres in Poland: A 2022 Survey

Author

Bobeff, Katarzyna, primary, Pastorczak, Agata, additional, Urbanska, Zuzanna, additional, Balwierz, Walentyna, additional, Juraszewska, Edyta, additional, Wachowiak, Jacek, additional, Derwich, Katarzyna, additional, Samborska, Magdalena, additional, Kalwak, Krzysztof, additional, Dachowska-Kalwak, Iwona, additional, Laguna, Paweł, additional, Malinowska, Iwona, additional, Smalisz, Katarzyna, additional, Gozdzik, Jolanta, additional, Oszer, Aleksandra, additional, Urbanski, Bartosz, additional, Zdunek, Maciej, additional, Szczepanski, Tomasz, additional, Mlynarski, Wojciech, additional, and Janczar, Szymon, additional

Published
2023
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8. Pediatric Acute Myeloid Leukemia Post Cytotoxic Therapy—Retrospective Analysis of the Patients Treated in Poland from 2005 to 2022

Author

Czogała, Małgorzata, primary, Czogała, Wojciech, additional, Pawińska-Wąsikowska, Katarzyna, additional, Książek, Teofila, additional, Bukowska-Strakova, Karolina, additional, Sikorska-Fic, Barbara, additional, Łaguna, Paweł, additional, Skalska-Sadowska, Jolanta, additional, Wachowiak, Jacek, additional, Rodziewicz-Konarska, Anna, additional, Moj-Hackemer, Małgorzata, additional, Kałwak, Krzysztof, additional, Muszyńska-Rosłan, Katarzyna, additional, Krawczuk-Rybak, Maryna, additional, Fałkowska, Anna, additional, Drabko, Katarzyna, additional, Kozłowska, Marta, additional, Irga-Jaworska, Ninela, additional, Bobeff, Katarzyna, additional, Młynarski, Wojciech, additional, Tomaszewska, Renata, additional, Szczepański, Tomasz, additional, Chodała-Grzywacz, Agnieszka, additional, Karolczyk, Grażyna, additional, Mycko, Katarzyna, additional, Badowska, Wanda, additional, Zielezińska, Karolina, additional, Urasiński, Tomasz, additional, Bartoszewicz, Natalia, additional, Styczyński, Jan, additional, Balwierz, Walentyna, additional, and Skoczeń, Szymon, additional

Published
2023
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9. Characteristics and treatment results of refractory and relapsed acute myeloid leukaemia in paediatric patients treated in Polish Paediatric Leukaemia/Lymphoma Study Group institutions according to the Protocol Acute Myeloid Leukaemia Berlin-Frankfurt-Munster 2012 and a review of novel treatment possibilities in paediatric acute myeloid leukaemia

Author

Samborska, Magdalena, primary, Skalska-Sadowska, Jolanta, additional, Achkar, Robert, additional, Wachowiak, Jacek, additional, Derwich, Katarzyna, additional, Czogała, Małgorzata, additional, Balwierz, Walentyna, additional, Skoczeń, Szymon, additional, Dobaczewski, Grzegorz, additional, Chybicka, Alicja, additional, Kałwak, Krzysztof, additional, Krawczuk-Rybak, Maryna, additional, Muszyńska-Rosłan, Katarzyna, additional, Adamkiewicz-Drożyńska, Elżbieta, additional, Maciejka-Kapuscińska, Lucyna, additional, Irga-Jaworska, Ninela, additional, Pohorecka, Joanna, additional, Chodała-Grzywacz, Agnieszka, additional, Karolczyk, Grażyna, additional, Wójcik, Beata, additional, Kowalczyk, Jerzy R., additional, Drabko, Katarzyna, additional, Zawitkowska, Joanna, additional, Mycko, Katarzyna, additional, Badowska, Wanda, additional, Ociepa, Tomasz, additional, Urasiński, Tomasz, additional, Sikorska-Fic, Barbara, additional, Matysiak, Michał, additional, Laguna, Paweł, additional, Dąbrowska-Pawliszyn, Anna, additional, Tomaszewska, Renata, additional, Szczepański, Tomasz, additional, Sobol, Grażyna, additional, Mizia-Malarz, Agnieszka, additional, Ciebiera, Małgorzata, additional, Chaber, Radosław, additional, Kołtan, Sylwia, additional, Wysocki, Mariusz, additional, Styczyński, Jan, additional, Woszczyk, Mariola, additional, Wieczorek, Maria, additional, Karpińska-Derda, Irena, additional, Urbańska-Rakus, Justyna, additional, Bobeff, Katarzyna, additional, Trelińska, Joanna, additional, and Młynarski, Wojciech, additional

Published
2023
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15. One Hundred Consecutive Neutropenic Febrile Episodes Demonstrate That CXCR3 Ligands Have Predictive Value in Discriminating the Severity of Infection in Children with Cancer.

Author

Nowak, Małgorzata, Bobeff, Katarzyna, Walenciak, Justyna, Kołodrubiec, Julia, Wyka, Krystyna, Młynarski, Wojciech, and Trelińska, Joanna

Subjects
INFECTION risk factors, BIOMARKERS, KRUSKAL-Wallis Test, FEBRILE neutropenia, PREDICTIVE tests, CONFIDENCE intervals, CELL receptors, SEVERITY of illness index, TUMORS in children, RISK assessment, PEARSON correlation (Statistics), CHI-squared test, RESEARCH funding, RECEIVER operating characteristic curves, ODDS ratio, CHEMOKINES, BLOOD, EVALUATION
Abstract

This study assesses the value of the CXCR3 ligands CXCL9/MIG, CXCL10/IP-10 and CXCL11/I-TAC when used to supplement the standard infection markers C-reactive protein (CRP) and procalcitonin (PCT) in the diagnostic algorithm of neutropenic fever in children with cancer. The concentration of CRP, PCT and chemokines was determined during the first hour of fever and 12–24 h afterwards in pediatric oncology patients with neutropenia. Among 100 consecutive febrile episodes in neutropenic patients, 34 cases demonstrated fever of unknown origin (FUO) (group A), 47 demonstrated mild clinically or microbiologically proven infection (Group B) and 19 severe infection (Group C). Significantly higher PCT-1 levels were found in group C (0.24 ng/mL) vs. group A (0.16 ng/mL), and PCT-2 in group C (1.2 ng/mL) vs. A (0.17 ng/mL), and in C vs. B (0.2 ng/mL). Chemokine concentrations (I-TAC-1, IP-10-1, IP-10-2) were significantly lower in Group A vs. B+C; I-TAC 1: 48.64 vs. 70.99 pg/mL, p = 0.03; IP-10 1: 59.95 vs. 96.84 pg/mL, p = 0.04; and IP-10 2: 102.40 vs. 149.39 pg/mL, p = 0.05. The selected pro-inflammatory chemokines I-TAC and IP10 might help to distinguish cancer patients with febrile neutropenia with the highest risk of infection. Although procalcitonin could serve as a marker of a high risk of infection, its delayed response diminishes its usefulness. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Advances in the First Line Treatment of Pediatric Acute Myeloid Leukemia in the Polish Pediatric Leukemia and Lymphoma Study Group from 1983 to 2019

Author

Czogała, Małgorzata, primary, Balwierz, Walentyna, additional, Pawińska-Wąsikowska, Katarzyna, additional, Książek, Teofila, additional, Bukowska-Strakova, Karolina, additional, Czogała, Wojciech, additional, Sikorska-Fic, Barbara, additional, Matysiak, Michał, additional, Skalska-Sadowska, Jolanta, additional, Wachowiak, Jacek, additional, Moj-Hackemer, Małgorzata, additional, Kałwak, Krzysztof, additional, Muszyńska-Rosłan, Katarzyna, additional, Krawczuk-Rybak, Maryna, additional, Grabowski, Dominik, additional, Kowalczyk, Jerzy, additional, Maciejka-Kembłowska, Lucyna, additional, Irga-Jaworska, Ninela, additional, Bobeff, Katarzyna, additional, Młynarski, Wojciech, additional, Tomaszewska, Renata, additional, Szczepański, Tomasz, additional, Chodała-Grzywacz, Agnieszka, additional, Karolczyk, Grażyna, additional, Mizia-Malarz, Agnieszka, additional, Mycko, Katarzyna, additional, Badowska, Wanda, additional, Zielezińska, Karolina, additional, Urasiński, Tomasz, additional, Urbańska-Rakus, Justyna, additional, Ciebiera, Małgorzata, additional, Chaber, Radosław, additional, Bartoszewicz, Natalia, additional, Wysocki, Mariusz, additional, and Skoczeń, Szymon, additional

Published
2021
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19. Nivolumab for the Treatment of Advanced Pediatric Malignancies

Author

MARJAŃSKA, AGATA, primary, DROGOSIEWICZ, MONIKA, additional, DEMBOWSKA-BAGIŃSKA, BOŻENNA, additional, PAWIŃSKA-WĄSIKOWSKA, KATARZYNA, additional, BALWIERZ, WALENTYNA, additional, BOBEFF, KATARZYNA, additional, MŁYNARSKI, WOJCIECH, additional, MIZIA-MALARZ, AGNIESZKA, additional, RACIBORSKA, ANNA, additional, WYSOCKI, MARIUSZ, additional, and STYCZYŃSKI, JAN, additional

Published
2020
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20. Retrospective Analysis of the Treatment Outcome in Myeloid Leukemia of Down Syndrome in Polish Pediatric Leukemia and Lymphoma Study Group From 2005 to 2019

Author

Czogala, Malgorzata, primary, Pawinska-Wasikowska, Katarzyna, additional, Ksiazek, Teofila, additional, Sikorska-Fic, Barbara, additional, Matysiak, Michal, additional, Skalska-Sadowska, Jolanta, additional, Wachowiak, Jacek, additional, Rodziewicz-Konarska, Anna, additional, Chybicka, Alicja, additional, Myszynska-Roslan, Katarzyna, additional, Krawczuk-Rybak, Maryna, additional, Grabowski, Dominik, additional, Kowalczyk, Jerzy, additional, Maciejka-Kemblowska, Lucyna, additional, Adamkiewicz-Drozynska, Elzbieta, additional, Bobeff, Katarzyna, additional, Mlynarski, Wojciech, additional, Tomaszewska, Renata, additional, Szczepanski, Tomasz, additional, Pohorecka, Joanna, additional, Chodala-Grzywacz, Agnieszka, additional, Karolczyk, Grazyna, additional, Mizia-Malarz, Agnieszka, additional, Mycko, Katarzyna, additional, Badowska, Wanda, additional, Zielezinska, Karolina, additional, Urasinski, Tomasz, additional, Nykiel, Magdalena, additional, Woszczyk, Mariola, additional, Ciebiera, Malgorzata, additional, Chaber, Radosław, additional, Skoczen, Szymon, additional, and Balwierz, Walentyna, additional

Published
2020
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21. Evaluation of skin autofluorescence as a surrogate of advanced glycation end products accumulation in children and adolescents with normal haemoglobin A1c values

Author

Jankowska, Marta, primary, Bobeff, Katarzyna, additional, Baranowska-Jaźwiecka, Anna, additional, Mianowska, Maria, additional, Lubnauer, Anna, additional, Michalak, Arkadiusz, additional, Młynarski, Wojciech, additional, Szadkowska, Agnieszka, additional, and Mianowska, Beata, additional

Published
2020
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23. Evaluation of skin autofluorescence as a surrogate of advanced glycation end products accumulation in children and adolescents with normal haemoglobin A1c values.

Author

Jankowska, Marta, Bobeff, Katarzyna, Baranowska-Jaźwiecka, Anna, Mianowska, Maria, Lubnauerq, Anna, Michalak, Arkadiusz, Młynarski, Wojciech, Szadkowska, Agnieszka, and Mianowska, Beata

Subjects
ADVANCED glycation end-products, BIOFLUORESCENCE, GLUCOSE metabolism disorders, JUVENILE diseases, HEMOGLOBINS
Abstract

Copyright of Pediatric Endocrinology, Diabetes & Metabolism is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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26. Diagnostic value of lateral ventricle ratio: a retrospective case-control study of 112 acute subdural hematomas after non-severe traumatic brain injury.

Author

Bobeff, Ernest J., Fortuniak, Jan, Bobeff, Katarzyna Ł., Wiśniewski, Karol, Wójcik, Rafał, Stefańczyk, Ludomir, and Jaskólski, Dariusz J.

Subjects
BRAIN injury treatment, CEREBRAL ventricles, BRAIN injuries, COMPUTED tomography, MULTIVARIATE analysis, RISK assessment, LOGISTIC regression analysis, SUBDURAL hematoma, TREATMENT effectiveness, RETROSPECTIVE studies, CASE-control method, RECEIVER operating characteristic curves, ACUTE diseases, PROTHROMBIN time, THERAPEUTICS
Abstract

Primary Objective: To evaluate correlation between the lateral ventricle ratio (LVR) and the risk of conservative treatment failure (CTF) among patients with acute subdural hematoma (ASDH) after non-severe traumatic brain injury (TBI), we retrieved from the hospital database and performed a retrospective analysis of 1339 cases with TBI treated during the 2008-2016 period. Methods and Procedures: 112 patients with ASDH, GCS≥ 9 and initial conservative treatment were enrolled. They were divided according to the final treatment method applied (surgical or conservative). Clinical and radiological data was evaluated. We used ROC curve analysis and multivariate logistic regression model to identify risk factors of CTF. Main Outcomes and Results: LVR higher than 1.48 calculated on admission CT scans was the strongest predictor of CTF, with sensitivity of 78.9% and specificity of 93.5% (AUC: 0.774-0.994). LVR, prolonged prothrombin time and coexisting traumatic subarachnoid hemorrhage were independent risk factors. Conclusions: Despite limitations, study results support the view that patients after non-severe TBI with ASDH and with lateral ventricle asymmetry, defined as LVR> 1.48, require surgical treatment. LVR seems to be indirect, but still the closest method to quantify intracranial compliance. Thus, in the selected group of patients without clinical symptoms of critically diminished compensatory reserve, LVR could indicate those who need a surgical decompression. [ABSTRACT FROM AUTHOR]

Published
2019
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27. Breaking the Taboo: Illicit Drug Use among Adolescents with Type 1 Diabetes Mellitus

Author

Hogendorf, Anna M., primary, Fendler, Wojciech, additional, Sieroslawski, Janusz, additional, Bobeff, Katarzyna, additional, Wegrewicz, Krzysztof, additional, Malewska, Kamila I., additional, Przudzik, Maciej W., additional, Szmigiero-Kawko, Malgorzata, additional, Sztangierska, Beata, additional, Mysliwiec, Malgorzata, additional, Szadkowska, Agnieszka, additional, and Mlynarski, Wojciech, additional

Published
2016
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28. Breaking the Taboo: Illicit Drug Use among Adolescents with Type 1 Diabetes Mellitus.

Author

Hogendorf, Anna M., Fendler, Wojciech, Sieroslawski, Janusz, Bobeff, Katarzyna, Wegrewicz, Krzysztof, Malewska, Kamila I., Przudzik, Maciej W., Szmigiero-Kawko, Malgorzata, Sztangierska, Beata, Mysliwiec, Malgorzata, Szadkowska, Agnieszka, and Mlynarski, Wojciech

Subjects
TEENAGERS, DRUG abuse, TYPE 1 diabetes, AGE factors in disease, METABOLIC regulation, CANNABIS (Genus), PHYSIOLOGY, GLYCEMIC control, PATIENTS
Abstract

Background. The aim of the study was to explore the prevalence of illicit drug use in a group of Polish adolescents with type 1 diabetes (DM1) in comparison with a national cohort of their healthy peers. Methods. Two hundred and nine adolescents with DM1, aged 15–18 years, were studied in 2013 with an anonymous questionnaire prepared for the European School Survey Project on Alcohol and Other Drugs (ESPAD). The control group was a representative sample of 12114 students at the same age who took part in ESPAD in 2011. Metabolic control was regarded as good if self-reported HbA1c was <8% or poor if HbA1c was ≥8%. Results. Lifetime prevalence of illicit drug use was lower among adolescents with DM1 than in the control group [58 (28%) versus 5524 (46%), p=10-5]. Cannabis preparations were the most frequently used substances [38 (18.3%) versus 3976 (33.1%), p=10-5], followed by tranquilizers, sedatives, and amphetamine. Lifetime and last 12-month use of cannabis were associated with poorer glycemic control (HbA1c ≥ 8%), p<0.01 and 0.02, respectively. Conclusions. Adolescents with DM1 report using illicit drugs to a lesser extent than their healthy peers. The use of cannabis is associated with a poorer metabolic control in teens with DM1. [ABSTRACT FROM AUTHOR]

Published
2015
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29. Analysis of early and treatment related deaths among children and adolescents with acute myeloid leukemia in Poland: 2005-2023.

Author

Pawińska-Wąsikowska K, Czogała M, Bukowska-Strakova K, Surman M, Rygielska M, Książek T, Sadowska B, Pac A, Skalska-Sadowska J, Samborska M, Wachowiak J, Ciebiera M, Chaber R, Tomaszewska R, Szczepański T, Zielezińska K, Urasiński T, Rodziewicz-Konarska A, Kałwak K, Kozłowska M, Irga-Jaworska N, Sikorska-Fic B, Chyżyński B, Łaguna P, Muszyńska-Rosłan K, Krawczuk-Rybak M, Deleszkiewicz P, Drabko K, Bobeff K, Młynarski W, Chodała-Grzywacz A, Karolczyk G, Mycko K, Badowska W, Bartoszewicz N, Styczyński J, Machnik K, Stolpa W, Mizia-Malarz A, Balwierz W, and Skoczeń S

Abstract

Background: A personalised approach to the treatment of acute myeloid leukemia (AML) in children and adolescents, as well as the development of supportive therapies, has significantly improved survival. Despite this, some patients still die before starting treatment or in an early phase of therapy before achieving remission. The study analysed the frequency, clinical features and risk factors for early deaths (ED) and treatment related deaths (TRD) of children and adolescents with AML., Methods: From January 2005 to November 2023, 646 children with AML treated in the centers of the Polish Pediatric Leukemia and Lymphoma Study Group according to three subsequent therapeutic protocols were evaluated: AML-BFM 2004 Interim (385 children), AML-BFM 2012 Registry (131 children) and AML-BFM 2019 (130 children)., Results: Out of 646 children, early death occurred in 30 children, including 15 girls. The median age was 10.7 years (1 day to 18 years). More than half of the patients (53%) were diagnosed with acute myelomonocytic leukemia (M5) and 13% with acute promyelocytic leukemia (M3). The ED rate for the three consecutive AML-BFM protocols was 4.9% vs. 5.3% vs. 3.1%, respectively. In 19 patients, death occurred before the 15th day of treatment, in 11 between the 15th and 42nd day. The most common cause of death before the 15th day (ED15) was leukostasis and bleeding, whereas between the 15th and 42nd day (ED15-42), infections, mainly bacterial sepsis. A significant association was found between ED15 and high leukocyte count (>10 × 10 9 /L), M3 leukemia ( p  < 0.001), and ED15-42 and age <1 year ( p  = 0.029). In the univariate analysis only initial high leukocyte count >100 × 10 9 /L, was a significant predictor of early death. The overall TRD for the entire study period was 3.4%. The main cause of death were infections, mainly bacterial sepsis (10 children out of 22, 45.4%)., Conclusions: Hyperleukocytosis remains significant factor of early mortality in patients with AML, despite the introduction of various cytoreductive methods. Infections are still the main cause of treatment related deaths. A more individualized approach by using new targeted drugs may be the therapeutic option of choice in the future., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (© 2024 Pawińska-Wąsikowska, Czogała, Bukowska-Strakova, Surman, Rygielska, Książek, Sadowska, Pac, Skalska-Sadowska, Samborska, Wachowiak, Ciebiera, Chaber, Tomaszewska, Szczepański, Zielezińska, Urasiński, Rodziewicz-Konarska, Kałwak, Kozłowska, Irga-jaworska, Sikorska-Fic, Chyżyński, Łaguna, Muszyńska-Rosłan, Krawczuk-Rybak, Deleszkiewicz, Drabko, Bobeff, Młynarski, Chodała-Grzywacz, Karolczyk, Mycko, Badowska, Bartoszewicz, Styczyński, Machnik, Stolpa, Mizia-Malarz, Balwierz and Skoczeń.)

Published
2024
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30. Characteristics and treatment results of refractory and relapsed acute myeloid leukaemia in paediatric patients treated in Polish Paediatric Leukaemia/Lymphoma Study Group institutions according to the Protocol Acute Myeloid Leukaemia Berlin-Frankfurt-Munster 2012 and a review of novel treatment possibilities in paediatric acute myeloid leukaemia.

Author

Samborska M, Skalska-Sadowska J, Achkar R, Wachowiak J, Derwich K, Czogała M, Balwierz W, Skoczeń S, Dobaczewski G, Chybicka A, Kałwak K, Krawczuk-Rybak M, Muszyńska-Rosłan K, Adamkiewicz-Drożyńska E, Maciejka-Kapuscińska L, Irga-Jaworska N, Pohorecka J, Chodała-Grzywacz A, Karolczyk G, Wójcik B, Kowalczyk JR, Drabko K, Zawitkowska J, Mycko K, Badowska W, Ociepa T, Urasiński T, Sikorska-Fic B, Matysiak M, Laguna P, Dąbrowska-Pawliszyn A, Tomaszewska R, Szczepański T, Sobol G, Mizia-Malarz A, Ciebiera M, Chaber R, Kołtan S, Wysocki M, Styczyński J, Woszczyk M, Wieczorek M, Karpińska-Derda I, Urbańska-Rakus J, Bobeff K, Trelińska J, and Młynarski W

Abstract

Introduction: This study aimed to present the clinical features and results of treatment of patients diagnosed with refractory or relapsed acute myeloid leukaemia (AML) in Polish Paediatric Leukaemia/Lymphoma Study Group (PPL/LSG) institutions, treated in accordance with the Protocol Acute Myeloid Leukaemia Berlin-Frankfurt-Munster 2012, as their first-line therapy., Material and Methods: The outcome data of 10 patients with refractory AML (median age 9.5 years) and 30 with relapsed AML (median age 12 years) were analysed retrospectively. Re-induction was usually based on idarubicin, fludarabine, and cytarabine along with allogeneic haematopoietic stem cell transplant (allo-HSCT) in 5 patients with refractory AML and 7 relapsed AML children., Results: 37.5% (3/8) of refractory AML patients achieved second complete remission second complete remission (CRII). One of ten patients (1/10; 10%) was alive and stayed in complete remission for 34 months after the allo-HSCT. The probability of 3-year event-free survival (pEFS) in this group was 0.125 ±0.11. In the group of relapsed AML patients, the CRII was achieved in 9 patients (34%), and the probability of survival was: pEFS = 0.24 ±0.08; probability overall survival (pOS) = 0.34 ±0.09, with significantly better results achieved in patients who underwent allo-HSCT (pOS = 0.54 ±0.14 vs. 0.08 ±0.08, p < 0.0001)., Conclusions: The prognosis of refractory AML and the first AML recurrence in children who were first-line treated in PPL/LSG centres according to Protocol Acute Myeloid Leukaemia Berlin-Frankfurt-Munster 2012 is poor. Failures of re-induction treatment particularly result from difficulties in achieving remission. Allogeneic HSCT improves prognosis in children with refractory and first recurrent AML, under the condition it is performed in complete remission. Novel therapeutic approaches are needed to increase the remission rate and improve the outcomes., Competing Interests: The author declares no conflict of interest., (Copyright © 2023 Termedia.)

Published
2023
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31. Fetuin-A and Interleukine-8 in Children with the Clinical Remission of Type 1 Diabetes.

Author

Pyziak-Skupien A, Bobeff K, Wyka K, Banach K, Malachowska B, Fendler W, Szadkowska A, Mlynarski W, and Zmyslowska A

Subjects
Adolescent, Biomarkers, Body Mass Index, Child, Child, Preschool, Cytokines blood, Diabetes Mellitus, Type 1 blood, Diabetes Mellitus, Type 1 diagnosis, Diabetes Mellitus, Type 1 therapy, Disease Management, Enzyme-Linked Immunosorbent Assay, Female, Humans, Insulin Resistance, Male, Odds Ratio, ROC Curve, Diabetes Mellitus, Type 1 metabolism, Interleukin-8 blood, alpha-2-HS-Glycoprotein metabolism
Abstract

Background: Clinical partial remission (CPR) in most patients with type 1 diabetes (T1D) is observed shortly after clinical diagnosis. Increasing body weight and impaired insulin sensitivity may play a role in the pathogenesis of CPR. Several cytokines can also participate in the development of insulin resistance., Objective: To evaluate the relationship between birth weight, body mass index, and the concentrations of IL-8 and Fetuin-A, and the presence of clinical partial remission in children at the T1D onset., Methods: The study group consisted of 134 children with a newly diagnosed T1D in whom the presence of CPR was evaluated in a further 2-year course of diabetes. The control group included 47 children without glucose tolerance disorders. The concentrations of IL-8 and Fetuin-A were determined by the ELISA method., Results: CPR occurred in 75.34% of T1D patients. At T1D onset, higher values of BMI SDS in the remitters as compared to the patients without remission were observed. At the T1D onset, the concentrations of Fetuin-A (p=0.031) and IL-8 (p=0.042) were significantly higher in patients compared to those without CPR., Conclusion: Evaluation of Fetuin-A and IL-8 levels in patients with a newly diagnosed T1D can differentiate between patients with or without CPR.

Published
2020
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