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126 results on '"Bobba, S."'

1. The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface

Author

Farese, Robert, Xu, N, Zhang, SO, Cole, RA, McKinney, SA, Guo, F, Haas, JT, Bobba, S, Farese, RV, and Mak, HY

Abstract

At the subcellular level, fat storage is confined to the evolutionarily conserved compartments termed lipid droplets (LDs), which are closely associated with the endoplasmic reticulum (ER). However, the molecular mechanisms that enable ER-LD interaction an

Published
2012

3. List of contributors

Author

Ayyala, D., primary, Ayyala, R.S., additional, Becker, S., additional, Blake, D.A., additional, Bobba, S., additional, Campbell, D., additional, Chen, F.K., additional, Chirila, T.V., additional, Connon, C.J., additional, Crawford, G.J., additional, Di Girolamo, N., additional, Eastlake, K., additional, Gouveia, R.M., additional, Harkin, D.G., additional, Hirst, L.W., additional, John, V.T., additional, Jones, M.F., additional, Klassen, H., additional, Kwan, A.S.L., additional, Lasowski, F.J.R., additional, Limb, G.A., additional, Mann, A., additional, Princz, M.A., additional, Ravi, N., additional, Reilly, M.A., additional, Sami, D.A., additional, Shadforth, A.M.A., additional, Sheardown, H., additional, Suzuki, S., additional, Swindle-Reilly, K.E., additional, Tao, S.L., additional, Tighe, B.J., additional, Watson, S., additional, Werner, L., additional, Yasukawa, T., additional, and Young, S.R., additional

Published
2016
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13. Critical raw materials and the circular economy

Author

Mathieux, F., Ardente, F., Bobba, S., Nuss, P., Blengini, G., Alves, Dias, Blagoeva, P., Torres De Matos, Wittmer, C., Pavel, D., Hamor, C., Saveyn, T., Gawlik, H., Orveillon, B., Huygens, G., Garbarino, D., Tzimas, E., Bouraoui, E., and Solar, F.

Subjects
products, Critical aw materials, science for policy, circular economy, Critical aw materials, science for policy, circular economy, products
Published
2017

17. Nature and incidence of severe limbal stem cell deficiency in Australia and New Zealand

Author

Bobba, S, Di Girolamo, N, Mills, R, Daniell, M, Chan, E, Harkin, DG, Cronin, BG, Crawford, G, McGhee, C, Watson, S, Bobba, S, Di Girolamo, N, Mills, R, Daniell, M, Chan, E, Harkin, DG, Cronin, BG, Crawford, G, McGhee, C, and Watson, S

Abstract

BACKGROUND: This study aimed to determine the nature and incidence of severe limbal stem cell deficiency (LSCD) in Australia and New Zealand. DESIGN: A 1-year pilot surveillance study with a 1-year follow-up period was conducted in association with the Australian and New Zealand Ophthalmic Surveillance Unit. PARTICIPANTS: The study included patients reported by practising ophthalmologists on the Surveillance Unit's database. METHODS: Ophthalmologists were provided with a definition of severe limbal stem cell deficiency, contacted on a monthly basis by the Unit and asked to report newly diagnosed cases. MAIN OUTCOME MEASURES: Severe LSCD was defined as at least 6 clock hours of whorl-like epitheliopathy, an opaque epithelium arising from the limbus, late fluorescein staining of the involved epithelium and superficial corneal neovascularization or conjunctivalization. RESULTS: On average, 286 report cards were sent by the Surveillance Unit to practising ophthalmologists each month (total 3429 over 12 months) and the Unit received an average of 176 responses per month (total 2111; 62% response rate). During the 1-year study period from April 2013 to March 2014, 14 positive cases were reported to the Unit. A range of underlying aetiologies were implicated, with contact lens over-wear and cicatrizing conjunctivitis being the most common (n = 3). CONCLUSIONS: This surveillance study is the first worldwide to document the incidence of limbal stem cell deficiency; however, because of study design limitations, it is likely to have been under-reported. It provides novel data on the demographics, clinical conditions and management of patients with limbal stem cell deficiency as reported by treating ophthalmologists.

Published
2017

20. Advances, challenges and opportunities in 3D CMOS sequential integration

Author

Batude, P., primary, Vinet, M., additional, Previtali, B., additional, Tabone, C., additional, Xu, C., additional, Mazurier, J., additional, Weber, O., additional, Andrieu, F., additional, Tosti, L., additional, Brevard, L., additional, Sklenard, B., additional, Coudrain, P., additional, Bobba, S., additional, Ben Jamaa, H., additional, Gaillardon, P-E., additional, Pouydebasque, A., additional, Thomas, O., additional, Le Royer, C., additional, Hartmann, J.-M., additional, Sanchez, L., additional, Baud, L., additional, Carron, V., additional, Clavelier, L., additional, De Micheli, G., additional, Deleonibus, S., additional, Faynot, O., additional, and Poiroux, T., additional

Published
2011
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36. Tracing the Fate of Limbal Epithelial Progenitor Cells in the Murine Cornea.

Author

Di Girolamo, N., Bobba, S., Raviraj, V., Delic, N. C., Slapetova, I., Nicovich, P. R., Halliday, G. M., Wakefield, D., Whan, R., and Lyons, J. G.

Subjects
PROGENITOR cells, EPITHELIAL cells, CORNEA, CELL differentiation, FLUORESCENT proteins, WOUND healing
Abstract

Stem cell (SC) division, deployment, and differentiation are processes that contribute to corneal epithelial renewal. Until now studying the destiny of these cells in a living mammal has not been possible. However, the advent of inducible multicolor genetic tagging and powerful imaging technologies has rendered this achievable in the translucent and readily accessible murine cornea. K14CreERT2-Confetti mice that harbor two copies of the Brainbow 2.1 cassette, yielding up to 10 colors from the stochastic recombination of fluorescent proteins, were used to monitor K-14+ progenitor cell dynamics within the corneal epithelium in live animals. Multicolored columns of cells emerged from the basal limbal epithelium as they expanded and migrated linearly at a rate of 10.8 µm/day toward the central cornea. Moreover, the permanent expression of fluorophores, passed on from progenitor to progeny, assisted in discriminating individual clones as spectrally distinct streaks containing more than 1,000 cells within the illuminated area. The centripetal clonal expansion is suggestive that a single progenitor cell is responsible for maintaining a narrow corridor of corneal epithelial cells. Our data are in agreement with the limbus as the repository for SC as opposed to SC being distributed throughout the central cornea. This is the first report describing stem/progenitor cell fate determination in the murine cornea using multicolor genetic tracing. This model represents a powerful new resource to monitor SC kinetics and fate choice under homeostatic conditions, and may assist in assessing clonal evolution during corneal development, aging, wound-healing, disease, and following transplantation. S tem C ells 2015;33:157-169 [ABSTRACT FROM AUTHOR]

Published
2015
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