25,719 results on '"Bo, Liu"'
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2. MonoDETRNext: Next-generation Accurate and Efficient Monocular 3D Object Detection Method
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Liao, Pan, Yang, Feng, Wu, Di, and Bo, Liu
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Monocular vision-based 3D object detection is crucial in various sectors, yet existing methods face significant challenges in terms of accuracy and computational efficiency. Building on the successful strategies in 2D detection and depth estimation, we propose MonoDETRNext, which seeks to optimally balance precision and processing speed. Our methodology includes the development of an efficient hybrid visual encoder, enhancement of depth prediction mechanisms, and introduction of an innovative query generation strategy, augmented by an advanced depth predictor. Building on MonoDETR, MonoDETRNext introduces two variants: MonoDETRNext-F, which emphasizes speed, and MonoDETRNext-A, which focuses on precision. We posit that MonoDETRNext establishes a new benchmark in monocular 3D object detection and opens avenues for future research. We conducted an exhaustive evaluation demonstrating the model's superior performance against existing solutions. Notably, MonoDETRNext-A demonstrated a 4.60% improvement in the AP3D metric on the KITTI test benchmark over MonoDETR, while MonoDETRNext-F showed a 2.21% increase. Additionally, the computational efficiency of MonoDETRNext-F slightly exceeds that of its predecessor.
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- 2024
3. Motion State: A New Benchmark Multiple Object Tracking
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Feng, Yang, Pan, Liao, Di, Wu, Bo, Liu, and Xingle, Zhang
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Computer Science - Computer Vision and Pattern Recognition - Abstract
In the realm of video analysis, the field of multiple object tracking (MOT) assumes paramount importance, with the motion state of objects-whether static or dynamic relative to the ground-holding practical significance across diverse scenarios. However, the extant literature exhibits a notable dearth in the exploration of this aspect. Deep learning methodologies encounter challenges in accurately discerning object motion states, while conventional approaches reliant on comprehensive mathematical modeling may yield suboptimal tracking accuracy. To address these challenges, we introduce a Model-Data-Driven Motion State Judgment Object Tracking Method (MoD2T). This innovative architecture adeptly amalgamates traditional mathematical modeling with deep learning-based multi-object tracking frameworks. The integration of mathematical modeling and deep learning within MoD2T enhances the precision of object motion state determination, thereby elevating tracking accuracy. Our empirical investigations comprehensively validate the efficacy of MoD2T across varied scenarios, encompassing unmanned aerial vehicle surveillance and street-level tracking. Furthermore, to gauge the method's adeptness in discerning object motion states, we introduce the Motion State Validation F1 (MVF1) metric. This novel performance metric aims to quantitatively assess the accuracy of motion state classification, furnishing a comprehensive evaluation of MoD2T's performance. Elaborate experimental validations corroborate the rationality of MVF1. In order to holistically appraise MoD2T's performance, we meticulously annotate several renowned datasets and subject MoD2T to stringent testing. Remarkably, under conditions characterized by minimal or moderate camera motion, the achieved MVF1 values are particularly noteworthy, with exemplars including 0.774 for the KITTI dataset, 0.521 for MOT17, and 0.827 for UAVDT.
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- 2023
4. DecoderTracker: Decoder-Only Method for Multiple-Object Tracking
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Pan, Liao, Feng, Yang, Di, Wu, Bo, Liu, and Xingle, Zhang
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Decoder-only models, such as GPT, have demonstrated superior performance in many areas compared to traditional encoder-decoder structure transformer models. Over the years, end-to-end models based on the traditional transformer structure, like MOTR, have achieved remarkable performance in multi-object tracking. However, the significant computational resource consumption of these models leads to less friendly inference speeds and training times. To address these issues, this paper attempts to construct a lightweight Decoder-only model: DecoderTracker for end-to-end multi-object tracking. Specifically, drawing on some real-time detection models, we have developed an image feature extraction network which can efficiently extract features from images to replace the encoder structure. In addition to minor innovations in the network, we analyze the potential reasons for the slow training of MOTR-like models and propose an effective training strategy to mitigate the issue of prolonged training times. On the DanceTrack dataset, without any bells and whistles, DecoderTracker's tracking performance slightly surpasses that of MOTR, with approximately twice the inference speed. Furthermore, DecoderTracker requires significantly less training time compared to MOTR.
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- 2023
5. Flavonoids from the Leaves and Stems of Cassia nodosa
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Sun, Qiong-hui, Yang, Shun-yi, Luo, Xing-li, Li, Min, Yu, Li-mei, Bo-Liu, Aisa, Haji Akber, and Chen, Ye-gao
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- 2024
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6. Chromosome-level genome assembly of Oriental chestnut gall wasp (Dryocosmus kuriphilus)
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Bo Liu, Ye-song Ren, Cheng-yuan Su, Xiu-dan Wang, Yang Zeng, and Dao-hong Zhu
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Science - Abstract
Abstract Dryocosmus kuriphilus, commonly known as the chestnut gall wasp, belongs to the family Cynipidae and is native to China. It is a highly invasive insect species causing serious damage to chestnut trees and has rapidly spread to various continents, including Europe, North America, and Oceania. The D. kuriphilus has become one of the important pests of chestnut plants in the world and is listed as a quarantine object by the European and Mediterranean Plant Protection Organization (EPPO). In this study, we used PacBio long reads, Illumina short reads, and Hi-C sequencing data to construct a chromosome-level assembly of the D. kuriphilus genome. The assembled genome includes 14,729 contigs with a total length of 2.28 Gb and a contig N50 of 0.8 Mb. With Hi-C technology, 2.17 Gb (95.02%) of contigs were anchored and oriented into the 10 pseudochromosomes with the scaffold N50 of 198.8 Mb and the scaffold N90 of 158.8 Mb. In total, 24,086 protein-coding genes were predicted in the assembled D. kuriphilus genome as the reference gene set. A total of 1.82 Gb repeats (occupying 79.7% of the genome), including 1.42 Gb of transposable elements and 0.40 Gb of tandem repeats, were identified in D. kuriphilus genome. In the evaluation of completeness, the BUSCO analysis determined a level of 98.1% completeness for the assembled genome sequences based on the Insecta database (OrthoDB version 10). The high-quality genome assembly of D. kuriphilus will not only provide a valuable reference for the study of its evolutionary history and genetic structure but also facilitate the research of host-pest interactions and invasiveness. Moreover, this genome assembly will promote in the development of effective management strategies to mitigate the economic and ecological impacts of this invasive pest on chestnut trees and ecosystems.
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- 2024
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7. Ginseng rusty root symptoms result from nitric oxide stress in soil
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Peng-cheng Yu, Wei Zhang, Li-yang Wang, Wen-fei Liu, Xiu-Bo Liu, Yao Yao, Xiao-wen Song, Zhao-Ping Meng, and Xiang-cai Meng
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Ginseng rusty root symptoms ,NO ,ROS ,Environmental stress ,Antioxidant oxidase ,Medicine ,Science - Abstract
Abstract Ginseng, from the roots of Panax ginseng C. A. Meyer, is a widely used herbal medicine in Asian countries, known for its excellent therapeutic properties. The growth of P. ginseng is depend on specific and strict environments, with a preference for wetness but intolerance for flooding. Under excessive soil moisture, some irregular rust-like substances are deposited on the root epidermis, causing ginseng rusty symptoms (GRS). This condition leads to a significant reduce in yield and quality, resulting in substantial economic loses. However, there is less knowledge on the cause of GRS and there are no effective treatments available for its treatment once it occurs. Unsuitable environments lead to the generation of large amounts of reactive oxygen species (ROS). We investigated the key indicators associated with the stress response during different physiological stages of GRS development. We observed a significant change in ROS level, MDA contents, antioxidant enzymes activities, and non-enzymatic antioxidants contents prior to the GRS. Through the analysis of soil features with an abundance of moisture, we further determined the source of ROS. The levels of nitrate reductase (NR) and nitric oxide synthase (NOS) activities in the inter-root soil of ginseng with GRS were significantly elevated compared to those of healthy ginseng. These enzymes boost nitric oxide (NO) levels, which in turn showed a favorable correlation with the GRS. The activities of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase first rose and then decreased as GRS developed. Excess soil moisture causes a decrease in oxygen levels. This activated NR and NOS in the soil, resulting in a production of excess NO. The NO then diffused into the ginseng root and triggered a burst of ROS through NADPH located on the cell membrane. Additionally, Fe2+ in soil was oxidized to red Fe3+, and finally led to GRS. This conclusion was also verified by the Sodium Nitroprusside (SNP), a precursor compound producing NO. The presence of NO from NR and NOS in water-saturated soil is responsible for the generation of ROS. Among these, NO is the main component that contribute to the occurrence of GRS.
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- 2024
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8. Bladder duplication in the male cat: the first case report in China
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Mingyuan Li, Yuqing Deng, Haoqian Liu, Jiaxu Sun, Shaokang Hong, Chen Lu, Christopher R. Mannion, Marta Carreño Gútiez, Bo Liu, and Feng Yu
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Feline medicine ,Bladder duplication ,Urogenital anomaly ,Diagnosis and treatment ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background Bladder duplication is a rare congenital lower urinary tract anomaly disease characterized by the presence of two bladders, possibly with duplication of the urethra. This disease is rarely reported in cats. The clinical symptoms are commonly occult, with increased difficulty in making a definitive diagnosis, especially if there is no obvious urethral duplication. The diagnosis is typically based on radiographs and ultrasound, with computer tomography serving as a more advanced imaging diagnostic modality. Cases of duplicated bladders with accessory tubular tissues are even scarcer in both human and veterinary medicine. Case presentation A 6-year-old male neutered cat was brought to the hospital because of vomiting and constipation. Cystography revealed increased soft tissue density of a fusiform structure in the lower middle abdomen. The purulent-filled cavitary structure and the accessory tubular structure were removed via surgery, and histopathological examination confirmed a double bladder with attached accessory tubular tissue. After antibiotic treatment, the cat recovered uneventfully. Conclusion This is the first case of bladder duplication in China and the first case of feline bladder duplication with tubular structure attachment in the world. This information will provide a reference for the diagnosis and treatment of similar cases in the future.
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- 2024
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9. CCL17, CCL22 and their receptor CCR4 in hematologic malignancies
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Shasha Zou, Bo Liu, and Yonghuai Feng
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CCL17 ,CCL22 ,CCR4 ,TME ,Immune escape ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Hematological malignancies (HM) are common malignant tumors with high morbidity and mortality rates, and are malignant diseases that seriously affect human health, with chemotherapy prone to recurrence and toxic side effects. Therefore, the development of precise, effective, and safe targeted therapeutic agents has become a hotspot in the current research of antitumor technology. More and more studies have shown that the interaction of C–C chemokine ligand 17 (CCL17) and C–C chemokine ligand 22 (CCL22) with the receptor C–C chemokine receptor type 4 (CCR4) promotes the immune escape of tumors and is closely related to the occurrence, development, and prognosis of hematological tumors. In this regard, we present a review on the expression and role of the CCL17/CCL22-CCR4 axis in HM, including lymphoma, leukemia, and multiple myeloma, with the aim of providing latest ideas and directions for the diagnosis and treatment of HM. In addition, we discuss the role and related mechanisms of HM therapeutic agents targeting the CCL17/CCL22-CCR4 axis and the potential of humanized anti-CCR4 antibodies for the treatment of HM.
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- 2024
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10. Efficacy and safety of fentanyl inhalant for the treatment of breakthrough cancer pain: a multicenter, randomized, double-blind, placebo-controlled trial
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Rongbo Lin, Binbin Song, Na Li, Biaoxue Rong, Jinghui Bai, Yong Liu, Wei Wang, Anwen Liu, Suxia Luo, Bo Liu, Peng Cheng, Yani Wu, Yujie Li, Xiaohui Yu, Xueying Liu, Xiangrong Dai, Xiaoyi Li, Dongying Liu, Jian Wang, and Yan Huang
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Breakthrough cancer pain ,Inhaled fentanyl ,Rapid-onset opioid ,Cancer pain ,Special situations and conditions ,RC952-1245 - Abstract
Abstract Background Breakthrough cancer pain (BTcP) has a negative impact on patients’ quality of life, general activities, and is related to worse clinical outcomes. Fentanyl inhalant is a hand-held combination drug-device delivery system providing rapid, multi-dose (25μg/dose) administration of fentanyl via inhalation of a thermally generated aerosol. This multicenter, randomized, placebo-controlled, multiple-crossover, double-blind study evaluated the efficacy, safety, and tolerability of fentanyl inhalant in treating BTcP in opioid-tolerant patients. Methods The trial was conducted in opioid-tolerant cancer patients with 1 ~ 4 BTcP outbursts per day. Each patient was treated and observed for 6 episodes of BTcP (4 with fentanyl inhalant, 2 with placebo). During each episode of targeted BTcP, patients were allowed up to six inhalations, with an interval of at least 4 min between doses. Primary outcome was the time-weighted sum of PID (pain intensity difference) scores at 30 min (SPID30). Results A total of 335 BTcP episodes in 59 patients were treated. The mean SPID30 was -97.4 ± 48.43 for fentanyl inhalant-treated episodes, and -64.6 ± 40.25 for placebo-treated episodes (p
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- 2024
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11. Development and commissioning of a broadband online X-ray spectrometer for the SXFEL Facility
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Zhicheng Yang, Ximing Zhang, Heping Geng, Jiahua Chen, Chao Feng, Bo Liu, and Bin Li
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free-electron lasers ,online grating spectrometer ,sud beamline ,e-tof spectrometer ,energy resolution ,pulse length ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 ,Crystallography ,QD901-999 - Abstract
A broadband online X-ray spectrometer has been designed and commissioned at the SUD beamline of the Shanghai Soft X-ray Free-Electron Laser Facility, which can deliver both SASE and seeded FEL pulses to user experiments, spanning the photon energy range of 50–620 eV. The resolving powers of the spectrometer calibrated via online measurement at 92 eV and 249 eV are ∼20000 and ∼15000, respectively, and the absolute photon energy is characterized by an electron time-of-flight spectrometer. The high energy resolution provided by the spectrometer can differentiate the fine structure in the FEL spectrum, to determine its pulse length.
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- 2024
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12. Quantitative evaluation on the cavitation damage energy of metals via multiscale approaches
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Meng Zhao, Yiran Wang, Wenjun Zhou, Youzhi Zhang, Bo Liu, and Xuanjun Wang
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Multiscale ,Cavitation erosion ,Impact damage ,Smoothed particles Hydrodynamics (SPH) ,Crystal plasticity finite element method (CPFEM) ,Mining engineering. Metallurgy ,TN1-997 - Abstract
In-situ experimental observation cannot be an effective method in the impact process of metal cavitation erosion, and the impact damage energy prediction theory has not been established based on a detailed mathematical and physical model. Research has shown that the metal material can be regarded as a sensor to reflect the impact parameters. Soft metal materials such as industrial pure copper with a single α-phase microstructure can be a suitable sensor to detect cavitation erosion effects, revealing the impact behaviors of the cavitation jet through the depth, width and spatial distribution of cavitation pits on the surface. In this scenario, volume loss of cavitation pits on a macro/mesoscale are obtained by three-dimensional surface measurement. A coupled fluid-solid simulation model calculating the impact damage energy on a macro/mesoscale is established based on the Smoothed Particle Hydrodynamics (SPH) and the Crystal Plasticity Finite Element Method (CPFEM). Python programming is used to set the trajectory of SPH particles to determine the macro cavitation flow field. IFEM methods were used to construct the prediction theory of cavitation impact energy in a relatively simple exponential equation, establishing the quantitative relationship between cavitation impact damage energy and measured volume of cavitation pits. Compared with conventional measurement and simulation, the present multiscale approaches are assumed as a further step advancement towards calculating the impact damage energy of cavitation water jet.
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- 2024
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13. Nematic Ising superconductivity with hidden magnetism in few-layer 6R-TaS2
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Shao-Bo Liu, Congkuan Tian, Yuqiang Fang, Hongtao Rong, Lu Cao, Xinjian Wei, Hang Cui, Mantang Chen, Di Chen, Yuanjun Song, Jian Cui, Jiankun Li, Shuyue Guan, Shuang Jia, Chaoyu Chen, Wenyu He, Fuqiang Huang, Yuhang Jiang, Jinhai Mao, X. C. Xie, Kam Tuen Law, and Jian-Hao Chen
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Science - Abstract
Abstract In van der Waals heterostructures (vdWHs), the manipulation of interlayer stacking/coupling allows for the construction of customizable quantum systems exhibiting exotic physics. An illustrative example is the diverse range of states of matter achieved through varying the proximity coupling between two-dimensional (2D) quantum spin liquid (QSL) and superconductors within the TaS2 family. This study presents a demonstration of the intertwined physics of spontaneous rotational symmetry breaking, hidden magnetism, and Ising superconductivity (SC) in the three-fold rotationally symmetric, non-magnetic natural vdWHs 6R-TaS2. A distinctive phase emerges in 6R-TaS2 below a characteristic temperature (T *) of approximately 30 K, which is characterized by a remarkable set of features, including a giant extrinsic anomalous Hall effect (AHE), Kondo screening, magnetic field-tunable thermal hysteresis, and nematic magneto-resistance. At lower temperatures, a coexistence of nematicity and Kondo screening with Ising superconductivity is observed, providing compelling evidence of hidden magnetism within a superconductor. This research not only sheds light on unexpected emergent physics resulting from the coupling of itinerant electrons and localized/correlated electrons in natural vdWHs but also emphasizes the potential for tailoring exotic quantum states through the manipulation of interlayer interactions.
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- 2024
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14. A predictive model for colorectal cancer complicated with intestinal obstruction based on specific inflammation score
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Wentai Cai, Zhenzhou Li, Bo Liu, and Yinghao Cao
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Colorectal cancer ,Obstruction ,Inflammation ,Specific inflammation score ,Prediction model ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Purpose Inflammatory factors play an important role in the onset and progression of colorectal cancer (CRC). This study aimed to develop and validate a novel scoring system that utilizes specific inflammatory factor indicators to predict intestinal obstruction in CRC patients. Methods This study conducted a retrospective analysis of 1,470 CRC patients who underwent surgical resection between January 2013 and July 2018. These patients were randomly allocated to the training group (n = 1060) and the validation group (n = 410). Univariate and multivariate logistic regression analyses were performed to identify independent predictive factors for intestinal obstruction. The CRC peculiar inflammation score (CPIS), comprising lymphocyte-to-monocyte ratio (LMR), prognostic nutrition index (PNI), and alanine transaminase-to-lymphocyte ratio index (ALRI) scores, was significantly associated with the occurrence of intestinal obstruction. A nomogram combining CPIS with other clinical features was developed to predict this occurrence. Model accuracy was assessed by determining the area under the receiver operating characteristic (ROC) curve (AUC). Results The CPIS generated by multi-factor logistic regression was as follows: − 1.576 × LMR − 0.067 × PNI + 0.018 × ALRI. Using CPIS cutoff values of 50% (− 7.188) and 85% (− 6.144), three predictive groups were established. Patients with a high CPIS had a significantly higher risk of intestinal obstruction than those with a low CPIS (odds ratio [OR]: 10.0, confidence interval [CI]: 5.85–17.08, P
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- 2024
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15. SALIRI‐based (raltitrexed plus irinotecan) therapy as a second‐line treatment for patients with metastatic colorectal cancer (SALLY): A prospective, multicenter, non‐interventional, registry study
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Shuqui Qin, Jin Li, Aiping Zhou, Yanqiao Zhang, Xianglin Yuan, Liangjun Zhu, Baoli Qin, Shan Zeng, Lin Shen, Ying Yuan, Weibo Wang, Jun Liang, Xianwen Zhang, Feng Ye, Ping Chen, Huaizhang Wang, Zhenyan Yu, Lu Yue, Yong Fang, Jianping Xiong, Jianwei Yang, Yiye Wan, Xianli Yin, Wenling Wang, Nong Xu, Xiaohong Wang, Zemin Xiao, Huafang Su, Ying Wang, Kangsheng Gu, Shuiping Tu, Zishu Wang, Bo Liu, Xiaohua Hu, Weixian Liu, and Xiaofeng Li
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2024
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16. Chromosome-level genome assembly of the invasive pest Pseudococcus jackbeardsleyi (Hemiptera: Pseudococcidae)
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Shaokun Guo, Bo Liu, Qingying Zhao, Zhihong Li, and Guoping Zhan
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Science - Abstract
Abstract Among over 2,000 species of mealybugs (Hemiptera: Pseudococcidae), only 13 genomes have been published so far, seriously limiting the researches on the phylogeny and adaptive evolution of this group. The continuous publication of mealybug genomes will significantly facilitate our exploration of the biological characteristics, detrimental attributes, and control strategies of the Pseudococcidae family. Jack Beardsley mealybug (Pseudococcus jackbeardsleyi) as one of the hazardous invasive pests, it could cause enormous losses to the fruit and vegetable industries worldwide. Herein, we combined Nanopore long-read, short-read Illumina and Hi-C sequencing, generating a high-quality chromosome-level genome assembly of P. jackbeardsleyi. The genome size was determined to be 334.818 Mb, which was assembled into 5 linkage groups with a N50 of 67.233 Mb. The BUSCO analysis demonstrated the completeness of the genome assembly and annotation are 95.7% and 92.8%, respectively. The developed high-quality genome will serve as an asset for delving into the genetic mechanisms underlying the invasiveness of P. jackbeardsleyi, thereby offering a crucial theoretical foundation for the prevention and management of Pseudococcidae pests.
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- 2024
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17. Tjong: A transformer‐based Mahjong AI via hierarchical decision‐making and fan backward
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Xiali Li, Bo Liu, Zhi Wei, Zhaoqi Wang, and Licheng Wu
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decision making ,deep learning ,deep neural networks ,Computational linguistics. Natural language processing ,P98-98.5 ,Computer software ,QA76.75-76.765 - Abstract
Abstract Mahjong, a complex game with hidden information and sparse rewards, poses significant challenges. Existing Mahjong AIs require substantial hardware resources and extensive datasets to enhance AI capabilities. The authors propose a transformer‐based Mahjong AI (Tjong) via hierarchical decision‐making. By utilising self‐attention mechanisms, Tjong effectively captures tile patterns and game dynamics, and it decouples the decision process into two distinct stages: action decision and tile decision. This design reduces decision complexity considerably. Additionally, a fan backward technique is proposed to address the sparse rewards by allocating reversed rewards for actions based on winning hands. Tjong consists of 15M parameters and is trained using approximately 0.5 M data over 7 days of supervised learning on a single server with 2 GPUs. The action decision achieved an accuracy of 94.63%, while the claim decision attained 98.55% and the discard decision reached 81.51%. In a tournament format, Tjong outperformed AIs (CNN, MLP, RNN, ResNet, VIT), achieving scores up to 230% higher than its opponents. Furthermore, after 3 days of reinforcement learning training, it ranked within the top 1% on the leaderboard on the Botzone platform.
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- 2024
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18. Varied clinical presentations of RP1L1 variants in Chinese patients: a study of occult macular dystrophy and vitelliform macular dystrophy
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Xiao Liu, Yanling Long, Yu Wang, Bo Liu, Jiayun Ren, Gang wang, Min Wang, Xiaohong Meng, and Yong Liu
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Occult macular dystrophy ,RP1L1 gene ,Phenotypic variability ,Vitelliform macular dystrophy ,Chinese patients ,Genetic analysis ,Ophthalmology ,RE1-994 - Abstract
Abstract Background Occult Macular Dystrophy (OMD), primarily caused by retinitis pigmentosa 1-like 1 (RP1L1) variants, is a complex retinal disease characterised by progressive vision loss and a normal fundus appearance. This study aims to investigate the diverse phenotypic expressions and genotypic correlations of OMD in Chinese patients, including a rare case of Vitelliform Macular Dystrophy (VMD) associated with RP1L1. Methods We analysed seven OMD patients and one VMD patient, all with heterozygous pathogenic RP1L1 variants. Clinical assessments included Best Corrected Visual Acuity (BCVA), visual field testing, Spectral Domain Optical Coherence Tomography (SD-OCT), multifocal Electroretinograms (mfERGs), and microperimetry. Next-generation sequencing was utilised for genetic analysis. Results The OMD patients displayed a range of phenotypic variability. Most (5 out of 7) had the RP1L1 variant c.133 C > T; p.R45W, associated with central vision loss and specific patterns in SD-OCT and mfERG. Two patients exhibited different RP1L1 variants (c.3599G > T; p.G1200V and c.2880G > C; p.W960C), presenting milder phenotypes. SD-OCT revealed photoreceptor layer changes, with most patients showing decreased mfERG responses in the central rings. Interestingly, a unique case of VMD linked to the RP1L1 variant was observed, distinct from traditional OMD presentations. Conclusions This study highlights the phenotypic diversity within OMD and the broader spectrum of RP1L1-associated macular dystrophies, including a novel association with VMD. The findings emphasise the complexity of RP1L1 variants in determining clinical manifestations, underscoring the need for comprehensive genetic and clinical evaluations in macular dystrophies.
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- 2024
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19. High-temperature capacitive energy storage in polymer nanocomposites through nanoconfinement
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Xinhui Li, Bo Liu, Jian Wang, Shuxuan Li, Xin Zhen, Jiapeng Zhi, Junjie Zou, Bei Li, Zhonghui Shen, Xin Zhang, Shujun Zhang, and Ce-Wen Nan
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Science - Abstract
Abstract Polymeric-based dielectric materials hold great potential as energy storage media in electrostatic capacitors. However, the inferior thermal resistance of polymers leads to severely degraded dielectric energy storage capabilities at elevated temperatures, limiting their applications in harsh environments. Here we present a flexible laminated polymer nanocomposite where the polymer component is confined at the nanoscale, achieving improved thermal-mechanical-electrical stability within the resulting nanocomposite. The nanolaminate, consisting of nanoconfined polyetherimide (PEI) polymer sandwiched between solid Al2O3 layers, exhibits a high energy density of 18.9 J/cm3 with a high energy efficiency of ~ 91% at elevated temperature of 200°C. Our work demonstrates that nanoconfinement of PEI polymer results in reduced diffusion coefficient and constrained thermal dynamics, leading to a remarkable increase of 37°C in glass-transition temperature compared to bulk PEI polymer. The combined effects of nanoconfinement and interfacial trapping within the nanolaminates synergistically contribute to improved electrical breakdown strength and enhanced energy storage performance across temperature range up to 250°C. By utilizing the flexible ultrathin nanolaminate on curved surfaces such as thin metal wires, we introduce an innovative concept that enables the creation of a highly efficient and compact metal-wired capacitor, achieving substantial capacitance despite the minimal device volume.
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- 2024
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20. Mouse adaptation of human inflammatory bowel diseases microbiota enhances colonization efficiency and alters microbiome aggressiveness depending on the recipient colonic inflammatory environment
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Simon M. Gray, Anh D. Moss, Jeremy W. Herzog, Saori Kashiwagi, Bo Liu, Jacqueline B. Young, Shan Sun, Aadra P. Bhatt, Anthony A. Fodor, and R. Balfour Sartor
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Inflammatory bowel diseases ,Experimental colitis ,Human microbiota associated mice ,Fecal microbiota transplant ,Microbiota transfer efficiency ,Mouse-adapted ,Microbial ecology ,QR100-130 - Abstract
Abstract Background Understanding the cause vs consequence relationship of gut inflammation and microbial dysbiosis in inflammatory bowel diseases (IBD) requires a reproducible mouse model of human-microbiota-driven experimental colitis. Results Our study demonstrated that human fecal microbiota transplant (FMT) transfer efficiency is an underappreciated source of experimental variability in human microbiota-associated (HMA) mice. Pooled human IBD patient fecal microbiota engrafted germ-free (GF) mice with low amplicon sequence variant (ASV)-level transfer efficiency, resulting in high recipient-to-recipient variation of microbiota composition and colitis severity in HMA Il-10 −/− mice. In contrast, mouse-to-mouse transfer of mouse-adapted human IBD patient microbiota transferred with high efficiency and low compositional variability resulting in highly consistent and reproducible colitis phenotypes in recipient Il-10 −/− mice. Engraftment of human-to-mouse FMT stochastically varied with individual transplantation events more than mouse-adapted FMT. Human-to-mouse FMT caused a population bottleneck with reassembly of microbiota composition that was host inflammatory environment specific. Mouse-adaptation in the inflamed Il-10 −/− host reassembled a more aggressive microbiota that induced more severe colitis in serial transplant to Il-10 −/− mice than the distinct microbiota reassembled in non-inflamed WT hosts. Conclusions Our findings support a model of IBD pathogenesis in which host inflammation promotes aggressive resident bacteria, which further drives a feed-forward process of dysbiosis exacerbated by gut inflammation. This model implies that effective management of IBD requires treating both the dysregulated host immune response and aggressive inflammation-driven microbiota. We propose that our mouse-adapted human microbiota model is an optimized, reproducible, and rigorous system to study human microbiome-driven disease phenotypes, which may be generalized to mouse models of other human microbiota-modulated diseases, including metabolic syndrome/obesity, diabetes, autoimmune diseases, and cancer. Video Abstract
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- 2024
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21. Effect of AC electric field on enhancing phytoremediation of Cd-contaminated soils in different pH soils
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Aiai Bu, Guihua Yao, Chuikang Zhou, Zhansheng Mao, Bo Liu, Jiawei Ma, Xianzhi Fang, Dan Liu, and Zhengqian Ye
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AC electric field ,Phytoremediation ,Sedum alfredii Hance ,Willow (Salix sp.) ,Cd contaminated soil ,pH ,Medicine ,Science - Abstract
Abstract To increase the efficiency of phytoremediation to clean up heavy metals in soil, assisted with alternating current (AC) electric field technology is a promising choice. Our experiments utilized the hyperaccumulator Sedum alfredii Hance and the fast-growing, high-biomass willow (Salix sp.). We investigated the efficiency of AC field combined with S. alfredii—willow intercropping for removing Cd from soils with different pH values. In the AC electric field treatment with S. alfredii—willow intercropping, the available Cd content in acidic soil increased by 50.00% compared to the control, and in alkaline soil, the increase was 100.00%. Furthermore, AC electric field promoted Cd uptake by plants in both acidic and alkaline soils, with Cd accumulation in the aboveground increased by 20.52% (P
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- 2024
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22. Oncogene goosecoid is transcriptionally regulated by E2F1 and correlates with disease progression in prostate cancer
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Yue Ge, Sheng Ma, Qiang Zhou, Zezhong Xiong, Yanan Wang, Le Li, Zheng Chao, Junbiao Zhang, Tengfei Li, Zixi Wu, Yuan Gao, Guanyu Qu, Zirui Xi, Bo Liu, Xi Wu, Zhihua Wang, and Yuanyuan Ji
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Medicine - Abstract
Abstract. Background:. Although some well-established oncogenes are involved in cancer initiation and progression such as prostate cancer (PCa), the long tail of cancer genes remains to be defined. Goosecoid (GSC) has been implicated in cancer development. However, the comprehensive biological role of GSC in pan-cancer, specifically in PCa, remains unexplored. The aim of this study was to investigate the role of GSC in PCa development. Methods:. We performed a systematic bioinformatics exploration of GSC using datasets from The Cancer Genome Atlas, Genotype-Tissue Expression, Gene Expression Omnibus, German Cancer Research Center, and our in-house cohorts. First, we evaluated the expression of GSC and its association with patient prognosis, and identified GSC-relevant genetic alterations in cancers. Further, we focused on the clinical characterization and prognostic analysis of GSC in PCa. To understand the transcriptional regulation of GSC by E2F transcription factor 1 (E2F1), we performed chromatin immunoprecipitation quantitative polymerase chain reaction (qPCR). Functional experiments were conducted to validate the effect of GSC on the tumor cellular phenotype and sensitivity to trametinib. Results:. GSC expression was elevated in various tumors and significantly correlated with patient prognosis. The alterations of GSC contribute to the progression of various tumors especially in PCa. Patients with PCa and high GSC expression exhibited worse progression-free survival and biochemical recurrence outcomes. Further, GSC upregulation in patients with PCa was mostly accompanied with higher Gleason score, advanced tumor stage, lymph node metastasis, and elevated prostate-specific antigen (PSA) levels. Mechanistically, the transcription factor, E2F1, stimulates GSC by binding to its promoter region. Detailed experiments further demonstrated that GSC acted as an oncogene and influenced the response of PCa cells to trametinib treatment. Conclusions:. GSC was highly overexpressed and strongly correlated with patient prognosis in PCa. We found that GSC, regulated by E2F1, acted as an oncogene and impeded the therapeutic efficacy of trametinib in PCa.
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- 2024
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23. Enhanced recovery after surgery in percutaneous transhepatic cholangioscopic lithotripsy for patients with hepatolithiasis and choledocholithiasis
- Author
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Peng Zhang, Xi Dang, Xiaojie Li, Bo Liu, and Qingliang Wang
- Subjects
ERAS ,Percutaneous transhepatic cholangioscopic lithotripsy ,Hepatolithiasis ,Choledocholithiasis ,Complication ,Surgery ,RD1-811 - Abstract
Background: Percutaneous transhepatic cholangioscopic lithotripsy (PTCSL) provides an effective alternative procedure for the management of complex hepatolithiasis and choledocholithiasis. Enhanced recovery after surgery (ERAS) program is an evidence-based approach that was developed to reduce surgical stress and accelerate postoperative recovery. However, little is known regarding PTCSL in the context of ERAS. The aim of this study was to evaluate the efficacy and safety of PTCSL within ERAS programs. Patient and methods: The clinical data of patients who underwent PTCSL within ERAS programs consulted at our hospital between November 2017 and November 2022 was retrospectively reviewed. Individualized perioperative ERAS items were evaluated for all patients. The demographics, intraoperative variables, and postoperative outcomes were analyzed. Results: A total of 43 patients who underwent PTCSL were included in the study. There were 13 men and 30 women aged between 39 and 89 years with an average age of 60 years (60.49 ± 12.37). The stone clearance rate was 77 % after the first operation, and the final clearance rate was 95 %. The incidence of complications in this study is 18.6 % (8/43), including 6 patients with Clavien-Dindo I-II, and 2 patients with Clavien-Dindo III. Pleural effusion, abdominal effusion, infection, bile leakage, and biliary bleeding are the most common complications, however, all patients recovered after aggressive treatment. Conclusion: PTCSL is a relatively safe, feasible, and efficient method for treating complex hepatolithiasis and choledocholithiasis within ERAS programs. Individualized ERAS entries and precise disease management are required to minimize the occurrence of complications and to provide effective treatment.
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- 2024
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24. Synergistic enhancement of hot corrosion resistance and mechanical properties of IN738LC alloy prepared by selective laser melting
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Yong Hu, Huibin Jia, Xu Zhang, Xiaokang Yang, Bo Liu, Jiayu Xu, Yubi Gao, Yutian Ding, and Dong Zhang
- Subjects
Selective laser melting (SLM) ,IN738LC alloy ,Heat treatment ,Hot corrosion ,Mechanical properties ,Mining engineering. Metallurgy ,TN1-997 - Abstract
The present study investigates the synergistic enhancement of hot corrosion resistance (900 °C, 75%Na2SO4+25%NaCl) and mechanical properties of IN738LC alloy prepared by selective laser melting after heat treatment. The results indicate that the M23C6 precipitation at the grain boundaries coupled with smaller-sized γ′ phase distribution in the inner grain is conducive to the formation of thicker Cr2O3 outer layer and Al2O3 inner layer for the samples, which effectively hinders the diffusion of S and Cl elements penetrate to the matrix, enhancing the hot corrosion resistance. Additionally, the presence of small-sized γ′ phase and re-crystallization-induced grain refinement contribute to an increase in yield strength (σYS = 1261 MPa) and ultimate tensile strength (σUTS = 1360 MPa) for the alloy.
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- 2024
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25. Chromosome-scale assembly of the wild cereal relative Elymus sibiricus
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Wenjie Shen, Bo Liu, Jialei Guo, Ying Yang, Xiaohui Li, Jie Chen, and Quanwen Dou
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Science - Abstract
Abstract Elymus species, belonging to Triticeae tribe, is a tertiary gene pool for improvement of major cereal crops. Elymus sibiricus, a tetraploid with StH genome, is a typical species in the genus Elymus, which is widely utilized as a high-quality perennial forage grass in template regions. In this study, we report the construction of a chromosome-scale reference assembly of E. sibiricus line Gaomu No. 1 based on PacBio HiFi reads and chromosome conformation capture. Subgenome St and H were well phased by assisting with kmer and subgenome-specific repetitive sequence. The total assembly size was 6.929 Gb with a contig N50 of 49.518 Mb. In total, 89,800 protein-coding genes were predicted. The repetitive sequences accounted for 82.49% of the genome in E. sibiricus. Comparative genome analysis confirmed a major species-specific 4H/6H reciprocal translocation in E. sibiricus. The E. sibiricus assembly will be much helpful to exploit genetic resource of StH species in genus Elymus, and provides an important tool for E. sibiricus domestication.
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- 2024
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26. A high-performance sub-THz planar antenna array for THz sensing and imaging applications
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Muhammad Zubair, Abdul Jabbar, Farooq A. Tahir, Jalil ur Rehman Kazim, Masood Ur Rehman, Muhammad Imran, Bo Liu, and Qammer H. Abbasi
- Subjects
Medicine ,Science - Abstract
Abstract Terahertz (THz) spectral region from 0.1 to 3 THz is envisaged to hold immense potential in the next generation of wireless technologies. Recently, research has focused on this terahertz gap, because of its unprecedented channel capacities. At the physical layer, the design complexities and fabrication of THz devices, especially antennas are the prime bottlenecks to realize its full potential. This article introduces a cost-effective, easy-to-fabricate, and reproducible sub-THz antenna design based on a single-layer planar printed circuit board technology. The antenna incorporates carefully designed quasi-cross slots and applied machine learning-assisted global optimization techniques to achieve the desired performance metrics. The antenna performance is elucidated through numerical simulations and verified through a rigorous in-house THz experimental framework around 100–110 GHz. The proposed antenna offers a peak gain of 13.90 dBi with less than 1 dB variation within the entire band of 100–110 GHz. The antenna holds the potential to achieve terabits per second data rates and futuristic high-resolution short-range THz imaging applications.
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- 2024
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27. Highly efficient pure-blue organic light-emitting diodes based on rationally designed heterocyclic phenophosphazinine-containing emitters
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Longjiang Xing, Jianghui Wang, Wen-Cheng Chen, Bo Liu, Guowei Chen, Xiaofeng Wang, Ji-Hua Tan, Season Si Chen, Jia-Xiong Chen, Shaomin Ji, Zujin Zhao, Man-Chung Tang, and Yanping Huo
- Subjects
Science - Abstract
Abstract Multi-resonance thermally activated delayed fluorophores have been actively studied for high-resolution photonic applications due to their exceptional color purity. However, these compounds encounter challenges associated with the inefficient spin-flip process, compromising device performance. Herein, we report two pure-blue emitters based on an organoboron multi-resonance core, incorporating a conformationally flexible donor, 10-phenyl-5H-phenophosphazinine 10-oxide (or sulfide). This design concept selectively modifies the orbital type of high-lying excited states to a charge transfer configuration while simultaneously providing the necessary conformational freedom to enhance the density of excited states without sacrificing color purity. We show that the different embedded phosphorus motifs (phosphine oxide/sulfide) of the donor can finely tune the electronic structure and conformational freedom, resulting in an accelerated spin-flip process through intense spin-vibronic coupling, achieving over a 20-fold increase in the reverse intersystem crossing rate compared to the parent multi-resonance emitter. Utilizing these emitters, we achieve high-performance pure-blue organic light-emitting diodes, showcasing a top-tier external quantum efficiency of 37.6% with reduced efficiency roll-offs. This proposed strategy not only challenges the conventional notion that flexible electron-donors are undesirable for constructing narrowband emitters but also offer a pathway for designing efficient narrow-spectrum blue organic light-emitting diodes.
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- 2024
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28. Research on a soft saturation nonlinear SSVEP signal feature extraction algorithm
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Bo Liu, Hongwei Gao, Yueqiu Jiang, and Jiaxuan Wu
- Subjects
Soft saturation ,Nonlinear ,SSVEP ,Feature extraction ,Decoding ,Intra-subject ,Medicine ,Science - Abstract
Abstract Brain–computer interfaces (BCIs) based on steady-state visual evoked potentials (SSVEP) have received widespread attention due to their high information transmission rate, high accuracy, and rich instruction set. However, the performance of its identification methods strongly depends on the amount of calibration data for within-subject classification. Some studies use deep learning (DL) algorithms for inter-subject classification, which can reduce the calculation process, but there is still much room for improvement in performance compared with intra-subject classification. To solve these problems, an efficient SSVEP signal recognition deep learning network model e-SSVEPNet based on the soft saturation nonlinear module is proposed in this paper. The soft saturation nonlinear module uses a similar exponential calculation method for output when it is less than zero, improving robustness to noise. Under the conditions of the SSVEP data set, two sliding time window lengths (1 s and 0.5 s), and three training data sizes, this paper evaluates the proposed network model and compares it with other traditional and deep learning model baseline methods. The experimental results of the nonlinear module were classified and compared. A large number of experimental results show that the proposed network has the highest average accuracy of intra-subject classification on the SSVEP data set, improves the performance of SSVEP signal classification and recognition, and has higher decoding accuracy under short signals, so it has huge potential ability to realize high-speed SSVEP-based for BCI.
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- 2024
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29. Enzyme/ROS dual-sensitive nanoplatform with on-demand Celastrol release capacity for enhanced ulcerative colitis therapy by ROS scavenging, microbiota rebalancing, inflammation alleviating
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Jinfeng Shi, Jiahui Zhou, Bo Liu, Kezhou Lin, Xingliang Xie, Xue Han, Yanmei Sheng, Yihan Liu, Congjian He, Yujin Zhou, Nan Zhu, Qian Yang, Ruifeng Luo, and Yi Li
- Subjects
Enzyme/ROS-triggered controlled release ,Ulcerative colitis ,Celastrol ,ROS scavengers ,Biotechnology ,TP248.13-248.65 ,Medical technology ,R855-855.5 - Abstract
Abstract Background The oral administration of drugs for treating ulcerative colitis (UC) is hindered by several factors, including inadequate gastrointestinal stability, insufficient accumulation in colonic lesions, and uncontrolled drug release. Methods A multiple sensitive nano-delivery system comprising β-cyclodextrin (CD) and 4-(hydroxymethyl)phenylboronic acid (PAPE) with enzyme/reactive oxygen species (ROS) sensitivity was developed to load celastrol (Cel) as a comprehensive treatment for UC. Results Owing to the positive charge in the site of inflamed colonic mucosa, the negatively charged nanomedicine (Cel/NPs) could efficiently accumulate. Expectedly, Cel/NPs showed excellent localization ability to colon in vitro and in vivo tests. The elevated concentration of ROS and intestinal enzymes in the colon microenvironment quickly break the CD, resulting in Cel release partially to rebalance microbiota and recover the intestinal barrier. The accompanying cellular internalization of residual Cel/NPs, along with the high concentration of cellular ROS to trigger Cel burst release, could decrease the expression of inflammatory cytokines, inhibit colonic cell apoptosis, promote the macrophage polarization, scavenge ROS, and regulate the TLR4/NF-κB signaling pathway, which certified that Cel/NPs possessed a notably anti-UC therapy outcome. Conclusions We provide a promising strategy for addressing UC symptoms via an enzyme/ROS-sensitive oral platform capable of releasing drugs on demand. Graphical Abstract
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- 2024
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30. TNKS1BP1 facilitates ubiquitination of CNOT4 by TRIM21 to promote hepatocellular carcinoma progression and immune evasion
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Yuan Wang, Ineza Karambizi Sandrine, Li Ma, Kailang Chen, Xinyi Chen, Yulong Yu, Sheng Wang, Lingyan Xiao, Chunya Li, Yuanhui Liu, Bo Liu, and Xianglin Yuan
- Subjects
Cytology ,QH573-671 - Abstract
Abstract Immune checkpoint inhibitors, particularly PD-1/PD-L1 blockades, have been approved for unresectable hepatocellular carcinoma (HCC). However, high resistance rates still limit their efficacy, highlighting the urgent need to understand the underlying mechanisms and develop strategies for overcoming the resistance. In this study, tankyrasel binding protein 1 (TNKS1BP1) was found to interact with tripartite motif containing 21 (TRIM21) and mediated the ubiquitination of CCR4-NOT transcription complex subunit 4 (CNOT4) at the K239 residue via K48 and K6 linkage, which was essential for its tumorigenesis function. Autophagy and lipid reprogramming were identified as two possible mechanisms underlying the pro-tumor effect of TNKS1BP1. Upregulated TNKS1BP1 inhibited autophagy while induced lipid accumulation by inhibiting the JAK2/STAT3 pathway upon the degradation of CNOT4 in HCC. Importantly, knocking down TNKS1BP1 synergized with anti-PD-L1 treatment by upregulating PD-L1 expression on tumor cells via the JAK2/STAT3 pathway, and remodeling the tumor microenvironment by increasing infiltration of tumor-infiltrating lymphocytes as well as augmenting the effect of cytotoxic T lymphocytes. In conclusion, this study identified TNKS1BP1 as a predictive biomarker for patient prognosis and a promising therapeutic target to overcome anti-PD-L1 resistance in HCC.
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- 2024
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31. ATM inhibition enhance immunotherapy by activating STING signaling and augmenting MHC Class I
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Chunya Li, Boyu Wang, Jingyao Tu, Chaofan Liu, Yuan Wang, Junjie Chen, Yongbiao Huang, Bo Liu, and Xianglin Yuan
- Subjects
Cytology ,QH573-671 - Abstract
Abstract Accumulating evidence supports the concept that DNA damage response targeted therapies can improve antitumor immune response by increasing the immunogenicity of tumor cells and improving the tumor immune microenvironment. Ataxia telangiectasia mutated (ATM) is a core component of the DNA repair system. Although the ATM gene has a significant mutation rate in many human cancers, including colorectal, prostate, lung, and breast, it remains understudied compared with other DDR-involved molecules such as PARP and ATR. Here, we found that either gene knockout or drug intervention, ATM inhibition activated the cGAS/STING pathway and augmented MHC class I in CRC cells, and these effects could be amplified by radiation. Furthermore, we found that MHC class I upregulation induced by ATM inhibition is dependent on the activation of the NFκB/IRF1/NLRC5 pathway and independent of STING. Animal experiments have shown increasing infiltration and cytotoxic function of T cells and better survival in ATM-deficient tumors. This work indicated that ATM nonsense mutation predicted the clinical benefits of radiotherapy combined with immune checkpoint blockade for patients with CRC. It also provides a molecular mechanism rationale for ATM-targeted agents for patients with CRC.
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- 2024
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32. Mechanism and optimization for the effect of solid solution treatment on microstructure and properties of recycled 7050-T7451 plate
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Jianwen Wang, Shengen Zhang, Sen Du, Zhengfeng Lv, Bo Liu, Mingtao Wang, Tongjian Huang, Chen Liu, Jingtao Wang, and Jun Liu
- Subjects
Recycled aluminum ,Aviation aluminum alloy ,Solid solution ,Properties optimization ,Mining engineering. Metallurgy ,TN1-997 - Abstract
The aviation grade-maintained recycling of 7XXX aluminum alloy has been achieved. However, there is still a lack of research on the optimization of the microstructure and properties of recycled aviation alloy. This work explores the effect of solid solution treatment on the microstructure and properties of recycled 7050-T7451 plate and its mechanism. The mechanism of “solid solution synergistic regulation of mechanics and corrosion resistance” was elucidated. After the solid solution of recycled aviation aluminum plates, the incomplete dissolution of Al2CuMg caused stress concentration and deteriorated the mechanical properties. In addition, the Cu clusters promoted the anodic dissolution of Al, reducing the corrosion resistance. Therefore, the solution temperature of recycled 7050 sheet was increased from 470 °C to 480 °C for 100 min. And the residual Al2CuMg was reduced by 56.6%, which synergistically improved the mechanical and corrosion resistance properties of recycled 7050 plates. The mechanical properties of two sets of recycled 7050-T7451 plates reached 516.3 MPa and 522.0 MPa, with elongation 17.5% and 17.3%, and there was no intergranular corrosion. This work explored the regulation mechanism of microstructure and properties of recycled 7050-T7451 plate, laying the foundation for the application of recycled aviation aluminum alloys.
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- 2024
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33. Particle-hole mixed Bogoliubov quasiparticles and Cooper instability in single-unit-cell FeSe/SrTiO3 films
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Zhiyuan Wei, Shaozhi Li, Bo Liu, Xiupeng Sun, Yinqi Hu, Shuai Sun, Shuting Peng, Yang Luo, Linwei Huai, Jianchang Shen, Bingqian Wang, Yu Miao, Zhipeng Ou, Yao Wang, Kun Jiang, and Junfeng He
- Subjects
Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Abstract In conventional superconductors, Bogoliubov quasiparticles and Cooper instability provide a paradigm to describe the superconducting state and the superconducting transition, respectively. However, whether these concepts can be adapted to describe Fe-based superconductors requires rigorous examinations from experiments. Here, we report angle-resolved photoemission studies on single-layer FeSe films grown on SrTiO3 substrate. Due to the improved clarity, our results reveal both particle and hole branches of the energy band with clear quasiparticles. The dispersion and coherence factors are extracted, which unveil the particle-hole mixed Bogoliubov quasiparticles in the superconducting state of the FeSe/STO films. Effective pairing susceptibility is also deduced as a function of temperature, which indicates the persistence of Cooper instability in Fe-based superconductors.
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- 2024
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34. Regulatory factors of Nrf2 in age-related macular degeneration pathogenesis
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Zi-Ling Hu, Yu-Xuan Wang, Zi-Yue Lin, Wen-Shuo Ren, Bo Liu, Hui Zhao, and Qiong Qin
- Subjects
nrf2 ,upstream regulators ,retinal pigment epithelia ,age-related macular degeneration ,oxidative stress ,Ophthalmology ,RE1-994 - Abstract
Age-related macular degeneration (AMD) is a complicated disease that causes irreversible visual impairment. Increasing evidences pointed retinal pigment epithelia (RPE) cells as the decisive cell involved in the progress of AMD, and the function of anti-oxidant capacity of PRE plays a fundamental physiological role. Nuclear factor erythroid 2 related factor 2 (Nrf2) is a significant transcription factor in the cellular anti-oxidant system as it regulates the expression of multiple anti-oxidative genes. Its functions of protecting RPE cells against oxidative stress (OS) and ensuing physiological changes, including inflammation, mitochondrial damage and autophagy dysregulation, have already been elucidated. Understanding the roles of upstream regulators of Nrf2 could provide further insight to the OS-mediated AMD pathogenesis. For the first time, this review summarized the reported upstream regulators of Nrf2 in AMD pathogenesis, including proteins and miRNAs, and their underlying molecular mechanisms, which may help to find potential targets via regulating the Nrf2 pathway in the future research and further discuss the existing Nrf2 regulators proved to be beneficial in preventing AMD.
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- 2024
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35. Three-dimensional distribution of subchondral fracture lines in osteonecrosis of the femoral head
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Yan-Bin Wu, Guang-Bo Liu, Huo Li, Jia-Zhou Wu, Jin-Shu Tang, Jian-Ting Ye, Ying-Jie Xiong, Xi-Wei Peng, Ze-Xian Liu, Yu-Zheng Lu, Cong-Cong Guan, Hao-Ye Meng, Xiao-Han Sun, Xin Wang, Ai-Yuan Wang, Zhe Zhao, Yuan Hu, Yu-Feng Liu, Li-Jun Sun, Ling Qin, and Jiang Peng
- Subjects
Collapse ,Computed tomography ,Osteonecrosis of the femoral head ,Three-dimensional distribution ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Objective: To investigate the characteristics of three-dimensional distribution of subchondral fracture lines on the surface of the osteonecrosis femoral head, and to discuss the underlying mechanisms that contribute to its collapse. Methods: We retrospectively analyzed computed tomography (CT) images from 75 patients (comprising a total of 77 femoral heads) diagnosed with Association Research Circulation Osseous (ARCO) stage IIIA or IIIB femoral head necrosis. The three-dimensional structures of both the femoral head and the subchondral fracture line were reconstructed and subsequently fitted into normal femoral head model. A heat map of fracture line was generated to visualize its spatial distribution across the femoral heads surface.to observe its distribution. In addition to that, the femoral head was partitioned into four zones, and the frequency of each fracture line traversing different zones was calculated and analysed. Results: Highest and lowest density of subchondral fracture lines was demonstrated in anterolateral and posterolateral zone respectively. and most sparse in posterolateral. Furthermore, the three-dimensional heat map of fracture lines highlighted their most frequent occurrence in the anterolateral area, particularly near the junction of the femoral head and neck. One fracture line may pass through multiple areas, passage frequencies for fracture lines was observed in zones I, II, III and IV for 66 times (85.7 %), 52 times (67.5 %), 25 times (32.5 %) and 46 times (59.7 %), respectively, with a significant difference between zone I and other zones (P
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- 2024
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36. Multiperiod optimization of cooling water system with flexible topology network
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Bo Liu, Ruimei Zhang, Ye Liu, Yufei Wang, Ali Almansoori, and Xiao Feng
- Subjects
Cooling water systems ,Flexible network ,Multiperiod optimization ,Air cooler ,Chemical engineering ,TP155-156 ,Biochemistry ,QD415-436 - Abstract
Cooling water systems (CWSs) are extensively utilized in various industries to eliminate the excess heat and converse energy. Studies on CWSs mainly concentrated on finding the optimal cooler network structure. In addition, some works also considered the optimal design under varied operation conditions. However, in these works, once the optimal design of the cooler's network is determined, its arrangement remains fixed and cannot be adapted to accommodate diverse operating conditions. In this work, a flexible topology network concept is proposed to make the adjustment of network structure possible under different operation conditions. The CWS with integrated air cooler and flexible topology network has better overall performance, represented by a mixed integer nonlinear programming (MINLP) model that require advanced tools such as GAMS software. Case studies revealed that the proposed methodology can realize better energy-saving performance, and improve the economic performance under varied operation conditions. The impact of critical flexible nodes on system configuration and economy is achieved by sensitivity analysis.
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- 2024
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37. Developing fibrin-based biomaterials/scaffolds in tissue engineering
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Songjie Li, Xin Dan, Han Chen, Tong Li, Bo Liu, Yikun Ju, Yang Li, Lanjie Lei, and Xing Fan
- Subjects
Fibrin ,Scaffold ,Tissue engineering ,Tissue repair ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Biology (General) ,QH301-705.5 - Abstract
Tissue engineering technology has advanced rapidly in recent years, offering opportunities to construct biologically active tissues or organ substitutes to repair or even enhance the functions of diseased tissues and organs. Tissue-engineered scaffolds rebuild the extracellular microenvironment by mimicking the extracellular matrix. Fibrin-based scaffolds possess numerous advantages, including hemostasis, high biocompatibility, and good degradability. Fibrin scaffolds provide an initial matrix that facilitates cell migration, differentiation, proliferation, and adhesion, and also play a critical role in cell-matrix interactions. Fibrin scaffolds are now widely recognized as a key component in tissue engineering, where they can facilitate tissue and organ defect repair. This review introduces the properties of fibrin, including its composition, structure, and biology. In addition, the modification and cross-linking modes of fibrin are discussed, along with various forms commonly used in tissue engineering. We also describe the biofunctionalization of fibrin. This review provides a detailed overview of the use and applications of fibrin in skin, bone, and nervous tissues, and provides novel insights into future research directions for clinical treatment.
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- 2024
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38. MMOOC: A Multimodal Misinformation Dataset for Out-of-Context News Analysis.
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Qingzheng Xu, Heming Du, Huiqiang Chen, Bo Liu 0001, and Xin Yu 0002
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- 2024
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39. A Multimodal Fake News Detection Model with Self-supervised Unimodal Label Generation.
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Yun Liu, Zhipeng Wen, Minzhu Jin, Daoxin Fan, Sifan Li, Bo Liu, Jinhe Jiang, and Xianda Xiao
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- 2024
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40. LAROD-HD: Low-Cost Adaptive Real-Time Object Detection for High-Resolution Video Surveillance.
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Yanglin Pu, Chen Gao 0005, Bo Liu 0005, Si Liu 0001, Shan Yang, Junhua Xiao, Shiliang Pu, Zhuhong You, and Yanbin Wang
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- 2024
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41. Positioning Method of Power Supply Quality Concentration Area Based on Power Customer Big Data Analysis.
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Longzhu Zhu, Bo Liu, Yanyan Li, Kunpeng Liu, and Jing Yang
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- 2024
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42. Hierarchical Knowledge Guided Fault Intensity Diagnosis of Complex Industrial Systems.
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Yu Sha, Shuiping Gou, Bo Liu 0054, Johannes Faber, Ningtao Liu, Stefan Schramm, Horst Stoecker, Thomas Steckenreiter, Domagoj Vnucec, Nadine Wetzstein, Andreas Widl, and Kai Zhou
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- 2024
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43. EasyGen: Easing Multimodal Generation with BiDiffuser and LLMs.
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Xiangyu Zhao, Bo Liu 0049, Qijiong Liu, Guangyuan Shi, and Xiao-Ming Wu 0003
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- 2024
44. STSPL-SSC: Semi-Supervised Few-Shot Short Text Clustering with Semantic text similarity Optimized Pseudo-Labels.
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Wenhua Nie, Lin Deng, Chang-Bo Liu, Jialing Wei, Ruitong Han, and Haoran Zheng
- Published
- 2024
45. Continual Dialogue State Tracking via Reason-of-Select Distillation.
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Yujie Feng, Bo Liu 0049, Xiaoyu Dong, Zexin Lu, Li-Ming Zhan, Xiao-Ming Wu 0003, and Albert Y. S. Lam
- Published
- 2024
46. TaSL: Continual Dialog State Tracking via Task Skill Localization and Consolidation.
- Author
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Yujie Feng, Xu Chu, Yongxin Xu, Guangyuan Shi, Bo Liu 0049, and Xiao-Ming Wu 0003
- Published
- 2024
47. Causal-Story: Local Causal Attention Utilizing Parameter-Efficient Tuning for Visual Story Synthesis.
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Tianyi Song, Jiuxin Cao, Kun Wang, Bo Liu, and Xiaofeng Zhang
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- 2024
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48. Small-Footprint Automatic Speech Recognition System using Two-Stage Transfer Learning based Symmetrized Ternary Weight Network.
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Xuanhao Zhang, Hui Kou, Chenjie Xia, Hao Cai, and Bo Liu 0019
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- 2024
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49. Research on Automatic Path Planning of Wind Turbines Inspection Based on Combined UAV.
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Zhaoying Li, Junqi Wu, Jian Xiong, and Bo Liu
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- 2024
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50. Random Matrix Theory Based Radio Frequency Fingerprinting Identification of WiFi Signal.
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You Jiang, Jian Xiong, Junqi Wu, and Bo Liu
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- 2024
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