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15 results on '"Bo, Bartolomeo"'

4. Spontaneous breathing in selected neonates with very mild congenital diaphragmatic hernia

Author

Kipfmueller, Florian, primary, Leyens, Judith, additional, Pugnaloni, Flaminia, additional, Bo, Bartolomeo, additional, Grass, Tamara, additional, Lemloh, Lotte, additional, Schroeder, Lukas, additional, Nitsch‐Felsecker, Patrizia, additional, Berg, Christoph, additional, Heydweiller, Andreas, additional, Strizek, Brigitte, additional, and Mueller, Andreas, additional

Published
2023
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12. Echocardiographic Assessment of Pulmonary Hypertension in Neonates with Congenital Diaphragmatic Hernia Using Pulmonary Artery Flow Characteristics

Author

Kipfmueller, Florian, primary, Akkas, Suemeyra, additional, Pugnaloni, Flaminia, additional, Bo, Bartolomeo, additional, Lemloh, Lotte, additional, Schroeder, Lukas, additional, Gembruch, Ulrich, additional, Geipel, Annegret, additional, Berg, Christoph, additional, Heydweiller, Andreas, additional, and Mueller, Andreas, additional

Published
2022
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13. Echocardiographic Assessment of Pulmonary Hypertension in Neonates with Congenital Diaphragmatic Hernia Using Pulmonary Artery Flow Characteristics

Author

Kipfmueller, Florian, Akkas, Suemeyra, Pugnaloni, Flaminia, Bo, Bartolomeo, Lemloh, Lotte, Schroeder, Lukas, Gembruch, Ulrich, Geipel, Annegret, Berg, Christoph, Heydweiller, Andreas, Mueller, Andreas, Kipfmueller, Florian, Akkas, Suemeyra, Pugnaloni, Flaminia, Bo, Bartolomeo, Lemloh, Lotte, Schroeder, Lukas, Gembruch, Ulrich, Geipel, Annegret, Berg, Christoph, Heydweiller, Andreas, and Mueller, Andreas

Abstract

Background: Assessment of pulmonary hypertension (PH) is essential in neonates with congenital diaphragmatic hernia (CDH). Echocardiography is widely established to quantify PH severity, but currently used parameters have inherent limitations. The aim of our study was to investigate the prognostic utility of the index of the pulmonary artery acceleration time to the right ventricular ejection time (PAAT:ET) in CDH neonates assessed using echocardiography. Methods: PAAT:ET values were prospectively measured in CDH neonates on admission, on day of life (DOL) 2 and DOL 5-7. Optimal cut-off values to predict mortality and need for ECMO were calculated and PAAT:ET values were compared between non-ECMO survivors, ECMO-survivors, and ECMO-non-survivors. Results: 87 CDH neonates were enrolled and 39 patients required ECMO therapy. At baseline, PAAT:ET values were significantly lower in ECMO patients compared to non-ECMO patients (p < 0.001). ECMO survivors and ECMO non-survivors had similar values at baseline (p = 0.967) and DOL 2 (p = 0.124) but significantly higher values at DOL 5-7 (p = 0.003). Optimal PAAT:ET cut-off for predicting ECMO was 0.290 at baseline and 0.310 for predicting non-survival in patients on ECMO at DOL 5-7. Conclusion: PAAT:ET is a feasible parameter for early risk assessment in CDH neonates.

Published
2022

15. [Characteristics and Outcome of Neonates With Postnatally Diagnosed Congenital Diaphragmatic Hernia].

Author

Bo BBL, Lemloh L, Hale L, Heydweiller A, Strizek B, Bendixen C, Schroeder L, Mueller A, and Kipfmueller F

Subjects
Child, Infant, Newborn, Female, Humans, Pregnancy, Retrospective Studies, Hernias, Diaphragmatic, Congenital diagnosis, Hernias, Diaphragmatic, Congenital therapy, Hernias, Diaphragmatic, Congenital complications, Abnormalities, Multiple
Abstract

Introduction: Congenital diaphragmatic hernia (CDH) is one of the most severe neonatal malformations with a mortality of 20-35%. Currently, the rate of prenatally recognized CDHs is 60-80%. This study investigated the characteristics and outcome data of children with prenatally unrecognized CDH., Methods: Postnatally diagnosed CDH newborns treated at the University Hospital Bonn between 2012 and 2021 were included. Treatment and outcome data were compared according to type of maternity hospital, Apgar values, and between prenatally and postnatally diagnosed CDH., Results: Of 244 CDH newborns, 22 were included. Comparison for birth in a facility with vs. without pediatric care showed for mortality: 9% vs. 27%, p=0.478; ECMO rate: 9% vs. 36%, p=0.300; age at diagnosis: 84 vs. 129 min, p=0.049; time between intubation and diagnosis: 20 vs. 86 min, p=0.019. Newborns in the second group showed significantly worse values for pH and pCO2. Furthermore, there was a tendency for higher mortality and ECMO rates in children with an Apgar score<7 vs.≥7. Children diagnosed postnatally were significantly more likely to have moderate or severe PH and tended to have cardiac dysfunction more often than those diagnosed prenatally., Discussion: In our cohort, ca. one in 10 newborns received a postnatal CDH diagnosis. Birth in a facility without pediatric care is associated with later diagnosis, which may favor hypercapnia/acidosis and more severe pulm., Competing Interests: Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht., (Thieme. All rights reserved.)

Published
2024
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