182 results on '"Blows, Fiona"'
Search Results
2. Incorporating progesterone receptor expression into the PREDICT breast prognostic model
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Grootes, Isabelle, Keeman, Renske, Blows, Fiona M, Milne, Roger L, Giles, Graham G, Swerdlow, Anthony J, Fasching, Peter A, Abubakar, Mustapha, Andrulis, Irene L, Anton-Culver, Hoda, Beckmann, Matthias W, Blomqvist, Carl, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Briceno, Ignacio, Burwinkel, Barbara, Camp, Nicola J, Castelao, Jose E, Choi, Ji-Yeob, Clarke, Christine L, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Devilee, Peter, Dörk, Thilo, Dunning, Alison M, Dwek, Miriam, Easton, Douglas F, Eccles, Diana M, Eriksson, Mikael, Ernst, Kristina, Evans, D Gareth, Figueroa, Jonine D, Fink, Visnja, Floris, Giuseppe, Fox, Stephen, Gabrielson, Marike, Gago-Dominguez, Manuela, García-Sáenz, José A, González-Neira, Anna, Haeberle, Lothar, Haiman, Christopher A, Hall, Per, Hamann, Ute, Harkness, Elaine F, Hartman, Mikael, Hein, Alexander, Hooning, Maartje J, Hou, Ming-Feng, Howell, Sacha J, Investigators, ABCTB, Investigators, kConFab, Ito, Hidemi, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jung, Audrey, Kang, Daehee, Kristensen, Vessela N, Kwong, Ava, Lambrechts, Diether, Li, Jingmei, Lubiński, Jan, Manoochehri, Mehdi, Margolin, Sara, Matsuo, Keitaro, Taib, Nur Aishah Mohd, Mulligan, Anna Marie, Nevanlinna, Heli, Newman, William G, Offit, Kenneth, Osorio, Ana, Park, Sue K, Park-Simon, Tjoung-Won, Patel, Alpa V, Presneau, Nadege, Pylkäs, Katri, Rack, Brigitte, Radice, Paolo, Rennert, Gad, Romero, Atocha, Saloustros, Emmanouil, Sawyer, Elinor J, Schneeweiss, Andreas, Schochter, Fabienne, Schoemaker, Minouk J, Shen, Chen-Yang, Shibli, Rana, Sinn, Peter, Tapper, William J, Tawfiq, Essa, Teo, Soo Hwang, Teras, Lauren R, Torres, Diana, Vachon, Celine M, van Deurzen, Carolien HM, Wendt, Camilla, and Williams, Justin A
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Cancer ,Breast Cancer ,Breast Neoplasms ,Female ,Humans ,Progesterone ,Prognosis ,Receptor ,ErbB-2 ,Receptors ,Progesterone ,PREDICT Breast ,breast cancer ,Progesterone receptor ,ABCTB Investigators ,kConFab Investigators ,Receptor ,erbB-2 ,Oncology and Carcinogenesis ,Public Health and Health Services ,Oncology & Carcinogenesis - Abstract
BackgroundPredict Breast (www.predict.nhs.uk) is an online prognostication and treatment benefit tool for early invasive breast cancer. The aim of this study was to incorporate the prognostic effect of progesterone receptor (PR) status into a new version of PREDICT and to compare its performance to the current version (2.2).MethodThe prognostic effect of PR status was based on the analysis of data from 45,088 European patients with breast cancer from 49 studies in the Breast Cancer Association Consortium. Cox proportional hazard models were used to estimate the hazard ratio for PR status. Data from a New Zealand study of 11,365 patients with early invasive breast cancer were used for external validation. Model calibration and discrimination were used to test the model performance.ResultsHaving a PR-positive tumour was associated with a 23% and 28% lower risk of dying from breast cancer for women with oestrogen receptor (ER)-negative and ER-positive breast cancer, respectively. The area under the ROC curve increased with the addition of PR status from 0.807 to 0.809 for patients with ER-negative tumours (p = 0.023) and from 0.898 to 0.902 for patients with ER-positive tumours (p = 2.3 × 10-6) in the New Zealand cohort. Model calibration was modest with 940 observed deaths compared to 1151 predicted.ConclusionThe inclusion of the prognostic effect of PR status to PREDICT Breast has led to an improvement of model performance and more accurate absolute treatment benefit predictions for individual patients. Further studies should determine whether the baseline hazard function requires recalibration.
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- 2022
3. Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia.
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Spurdle, Amanda B, Couch, Fergus J, Parsons, Michael T, McGuffog, Lesley, Barrowdale, Daniel, Bolla, Manjeet K, Wang, Qin, Healey, Sue, Schmutzler, Rita, Wappenschmidt, Barbara, Rhiem, Kerstin, Hahnen, Eric, Engel, Christoph, Meindl, Alfons, Ditsch, Nina, Arnold, Norbert, Plendl, Hansjoerg, Niederacher, Dieter, Sutter, Christian, Wang-Gohrke, Shan, Steinemann, Doris, Preisler-Adams, Sabine, Kast, Karin, Varon-Mateeva, Raymonda, Ellis, Steve, Frost, Debra, Platte, Radka, Perkins, Jo, Evans, D Gareth, Izatt, Louise, Eeles, Ros, Adlard, Julian, Davidson, Rosemarie, Cole, Trevor, Scuvera, Giulietta, Manoukian, Siranoush, Bonanni, Bernardo, Mariette, Frederique, Fortuzzi, Stefano, Viel, Alessandra, Pasini, Barbara, Papi, Laura, Varesco, Liliana, Balleine, Rosemary, Nathanson, Katherine L, Domchek, Susan M, Offitt, Kenneth, Jakubowska, Anna, Lindor, Noralane, Thomassen, Mads, Jensen, Uffe Birk, Rantala, Johanna, Borg, Åke, Andrulis, Irene L, Miron, Alexander, Hansen, Thomas VO, Caldes, Trinidad, Neuhausen, Susan L, Toland, Amanda E, Nevanlinna, Heli, Montagna, Marco, Garber, Judy, Godwin, Andrew K, Osorio, Ana, Factor, Rachel E, Terry, Mary B, Rebbeck, Timothy R, Karlan, Beth Y, Southey, Melissa, Rashid, Muhammad Usman, Tung, Nadine, Pharoah, Paul DP, Blows, Fiona M, Dunning, Alison M, Provenzano, Elena, Hall, Per, Czene, Kamila, Schmidt, Marjanka K, Broeks, Annegien, Cornelissen, Sten, Verhoef, Senno, Fasching, Peter A, Beckmann, Matthias W, Ekici, Arif B, Slamon, Dennis J, Bojesen, Stig E, Nordestgaard, Børge G, Nielsen, Sune F, Flyger, Henrik, Chang-Claude, Jenny, Flesch-Janys, Dieter, Rudolph, Anja, Seibold, Petra, Aittomäki, Kristiina, Muranen, Taru A, Heikkilä, Päivi, Blomqvist, Carl, Figueroa, Jonine, Chanock, Stephen J, and Brinton, Louise
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ABCTB Investigators ,EMBRACE Group ,GENICA Network ,HEBON Group ,kConFab Investigators ,Humans ,Carcinoma ,Breast Neoplasms ,Receptor ,erbB-2 ,Receptors ,Estrogen ,Receptors ,Progesterone ,Neoplasm Staging ,Likelihood Functions ,Age Factors ,Mutation ,Genes ,BRCA1 ,Genes ,BRCA2 ,Adult ,Aged ,Middle Aged ,Female ,Neoplasm Grading ,Triple Negative Breast Neoplasms ,Receptor ,ErbB-2 ,Receptor ,erbB-2 ,Receptors ,Estrogen ,Progesterone ,Genes ,BRCA1 ,BRCA2 ,ErbB-2 ,Prevention ,Breast Cancer ,Cancer ,Genetics ,4.2 Evaluation of markers and technologies ,Oncology & Carcinogenesis ,Oncology and Carcinogenesis - Abstract
IntroductionThe distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling.MethodsSelection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the likelihood of mutation status by histopathological markers were derived using a Mantel-Haenszel approach.ResultsER-positive phenotype negatively predicted BRCA1 mutation status, irrespective of grade (LRs from 0.08 to 0.90). ER-negative grade 3 histopathology was more predictive of positive BRCA1 mutation status in women 50 years or older (LR = 4.13 (3.70 to 4.62)) versus younger than 50 years (LR = 3.16 (2.96 to 3.37)). For BRCA2, ER-positive grade 3 phenotype modestly predicted positive mutation status irrespective of age (LR = 1.7-fold), whereas ER-negative grade 3 features modestly predicted positive mutation status at 50 years or older (LR = 1.54 (1.27 to 1.88)). Triple-negative tumor status was highly predictive of BRCA1 mutation status for women younger than 50 years (LR = 3.73 (3.43 to 4.05)) and 50 years or older (LR = 4.41 (3.86 to 5.04)), and modestly predictive of positive BRCA2 mutation status in women 50 years or older (LR = 1.79 (1.42 to 2.24)).ConclusionsThese results refine likelihood-ratio estimates for predicting BRCA1 and BRCA2 mutation status by using commonly measured histopathological features. Age at diagnosis is an important variable for most analyses, and grade is more informative than ER status for BRCA2 mutation carrier prediction. The estimates will improve BRCA1 and BRCA2 variant classification and inform patient mutation testing and clinical management.
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- 2014
4. Refined histopathological predictors of BRCA1 and BRCA2mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia
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Spurdle, Amanda B, Couch, Fergus J, Parsons, Michael T, McGuffog, Lesley, Barrowdale, Daniel, Bolla, Manjeet K, Wang, Qin, Healey, Sue, Schmutzler, Rita Katharina, Wappenschmidt, Barbara, Rhiem, Kerstin, Hahnen, Eric, Engel, Christoph, Meindl, Alfons, Ditsch, Nina, Arnold, Norbert, Plendl, Hansjoerg, Niederacher, Dieter, Sutter, Christian, Wang-Gohrke, Shan, Steinemann, Doris, Preisler-Adams, Sabine, Kast, Karin, Varon-Mateeva, Raymonda, Ellis, Steve, Frost, Debra, Platte, Radka, Perkins, Jo, Evans, D Gareth, Izatt, Louise, Eeles, Ros, Adlard, Julian, Davidson, Rosemarie, Cole, Trevor, Scuvera, Giulietta, Manoukian, Siranoush, Bonanni, Bernardo, Mariette, Frederique, Fortuzzi, Stefano, Viel, Alessandra, Pasini, Barbara, Papi, Laura, Varesco, Liliana, Balleine, Rosemary, Nathanson, Katherine L, Domchek, Susan M, Offitt, Kenneth, Jakubowska, Anna, Lindor, Noralane, Thomassen, Mads, Jensen, Uffe Birk, Rantala, Johanna, Borg, Åke, Andrulis, Irene L, Miron, Alexander, Hansen, Thomas VO, Caldes, Trinidad, Neuhausen, Susan L, Toland, Amanda E, Nevanlinna, Heli, Montagna, Marco, Garber, Judy, Godwin, Andrew K, Osorio, Ana, Factor, Rachel E, Terry, Mary B, Rebbeck, Timothy R, Karlan, Beth Y, Southey, Melissa, Rashid, Muhammad Usman, Tung, Nadine, Pharoah, Paul DP, Blows, Fiona M, Dunning, Alison M, Provenzano, Elena, Hall, Per, Czene, Kamila, Schmidt, Marjanka K, Broeks, Annegien, Cornelissen, Sten, Verhoef, Senno, Fasching, Peter A, Beckmann, Matthias W, Ekici, Arif B, Slamon, Dennis J, Bojesen, Stig E, Nordestgaard, Børge G, Nielsen, Sune F, Flyger, Henrik, Chang-Claude, Jenny, Flesch-Janys, Dieter, Rudolph, Anja, Seibold, Petra, Aittomäki, Kristiina, Muranen, Taru A, Heikkilä, Päivi, Blomqvist, Carl, Figueroa, Jonine, Chanock, Stephen J, and Brinton, Louise
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Breast Cancer ,Cancer ,Prevention ,Genetics ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Adult ,Age Factors ,Aged ,Breast Neoplasms ,Carcinoma ,Female ,Genes ,BRCA1 ,Genes ,BRCA2 ,Humans ,Likelihood Functions ,Middle Aged ,Mutation ,Neoplasm Grading ,Neoplasm Staging ,Receptor ,ErbB-2 ,Receptors ,Estrogen ,Receptors ,Progesterone ,Triple Negative Breast Neoplasms ,ABCTB Investigators ,EMBRACE Group ,GENICA Network ,HEBON Group ,kConFab Investigators ,Receptor ,erbB-2 ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
The distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling. Selection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the likelihood of mutation status by histopathological markers were derived using a Mantel-Haenszel approach. ER-positive phenotype negatively predicted BRCA1 mutation status, irrespective of grade (LRs from 0.08 to 0.90). ER-negative grade 3 histopathology was more predictive of positive BRCA1 mutation status in women 50 years or older (LR = 4.13 (3.70 to 4.62)) versus younger than 50 years (LR = 3.16 (2.96 to 3.37)). For BRCA2, ER-positive grade 3 phenotype modestly predicted positive mutation status irrespective of age (LR = 1.7-fold), whereas ER-negative grade 3 features modestly predicted positive mutation status at 50 years or older (LR = 1.54 (1.27 to 1.88)). Triple-negative tumor status was highly predictive of BRCA1 mutation status for women younger than 50 years (LR = 3.73 (3.43 to 4.05)) and 50 years or older (LR = 4.41 (3.86 to 5.04)), and modestly predictive of positive BRCA2 mutation status in women 50 years or older (LR = 1.79 (1.42 to 2.24)). These results refine likelihood-ratio estimates for predicting BRCA1 and BRCA2 mutation status by using commonly measured histopathological features. Age at diagnosis is an important variable for most analyses, and grade is more informative than ER status for BRCA2 mutation carrier prediction. The estimates will improve BRCA1 and BRCA2 variant classification and inform patient mutation testing and clinical management.
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- 2014
5. Combined quantitative measures of ER, PR, HER2, and KI67 provide more prognostic information than categorical combinations in luminal breast cancer
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Abubakar, Mustapha, Figueroa, Jonine, Ali, H.Raza, Blows, Fiona, Lissowska, Jolanta, Caldas, Carlos, Easton, Douglas F., Sherman, Mark E., Garcia-Closas, Montserrat, Dowsett, Mitch, and Pharoah, Paul D.
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- 2019
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6. Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies.
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Yang, Xiaohong R, Chang-Claude, Jenny, Goode, Ellen L, Couch, Fergus J, Nevanlinna, Heli, Milne, Roger L, Gaudet, Mia, Schmidt, Marjanka K, Broeks, Annegien, Cox, Angela, Fasching, Peter A, Hein, Rebecca, Spurdle, Amanda B, Blows, Fiona, Driver, Kristy, Flesch-Janys, Dieter, Heinz, Judith, Sinn, Peter, Vrieling, Alina, Heikkinen, Tuomas, Aittomäki, Kristiina, Heikkilä, Päivi, Blomqvist, Carl, Lissowska, Jolanta, Peplonska, Beata, Chanock, Stephen, Figueroa, Jonine, Brinton, Louise, Hall, Per, Czene, Kamila, Humphreys, Keith, Darabi, Hatef, Liu, Jianjun, Van 't Veer, Laura J, van Leeuwen, Flora E, Andrulis, Irene L, Glendon, Gord, Knight, Julia A, Mulligan, Anna Marie, O'Malley, Frances P, Weerasooriya, Nayana, John, Esther M, Beckmann, Matthias W, Hartmann, Arndt, Weihbrecht, Sebastian B, Wachter, David L, Jud, Sebastian M, Loehberg, Christian R, Baglietto, Laura, English, Dallas R, Giles, Graham G, McLean, Catriona A, Severi, Gianluca, Lambrechts, Diether, Vandorpe, Thijs, Weltens, Caroline, Paridaens, Robert, Smeets, Ann, Neven, Patrick, Wildiers, Hans, Wang, Xianshu, Olson, Janet E, Cafourek, Victoria, Fredericksen, Zachary, Kosel, Matthew, Vachon, Celine, Cramp, Helen E, Connley, Daniel, Cross, Simon S, Balasubramanian, Sabapathy P, Reed, Malcolm WR, Dörk, Thilo, Bremer, Michael, Meyer, Andreas, Karstens, Johann H, Ay, Aysun, Park-Simon, Tjoung-Won, Hillemanns, Peter, Arias Pérez, Jose Ignacio, Menéndez Rodríguez, Primitiva, Zamora, Pilar, Benítez, Javier, Ko, Yon-Dschun, Fischer, Hans-Peter, Hamann, Ute, Pesch, Beate, Brüning, Thomas, Justenhoven, Christina, Brauch, Hiltrud, Eccles, Diana M, Tapper, William J, Gerty, Sue M, Sawyer, Elinor J, Tomlinson, Ian P, Jones, Angela, Kerin, Michael, Miller, Nicola, McInerney, Niall, Anton-Culver, Hoda, and Ziogas, Argyrios
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Humans ,Breast Neoplasms ,Obesity ,Receptor ,erbB-2 ,Receptors ,Estrogen ,Receptors ,Progesterone ,Body Mass Index ,Logistic Models ,Odds Ratio ,Risk Factors ,Case-Control Studies ,Age Factors ,Parity ,Parturition ,Menarche ,Female ,Keratin-5 ,ErbB Receptors ,Biomarkers ,Tumor ,Receptor ,ErbB-2 ,Prevention ,Cancer ,Aging ,Breast Cancer ,Clinical Research ,Aetiology ,2.1 Biological and endogenous factors ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BackgroundPrevious studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors.MethodsWe pooled tumor marker and epidemiological risk factor data from 35,568 invasive breast cancer case patients from 34 studies participating in the Breast Cancer Association Consortium. Logistic regression models were used in case-case analyses to estimate associations between epidemiological risk factors and tumor subtypes, and case-control analyses to estimate associations between epidemiological risk factors and the risk of developing specific tumor subtypes in 12 population-based studies. All statistical tests were two-sided.ResultsIn case-case analyses, of the epidemiological risk factors examined, early age at menarche (≤12 years) was less frequent in case patients with PR(-) than PR(+) tumors (P = .001). Nulliparity (P = 3 × 10(-6)) and increasing age at first birth (P = 2 × 10(-9)) were less frequent in ER(-) than in ER(+) tumors. Obesity (body mass index [BMI] ≥ 30 kg/m(2)) in younger women (≤50 years) was more frequent in ER(-)/PR(-) than in ER(+)/PR(+) tumors (P = 1 × 10(-7)), whereas obesity in older women (>50 years) was less frequent in PR(-) than in PR(+) tumors (P = 6 × 10(-4)). The triple-negative (ER(-)/PR(-)/HER2(-)) or core basal phenotype (CBP; triple-negative and cytokeratins [CK]5/6(+) and/or epidermal growth factor receptor [EGFR](+)) accounted for much of the heterogeneity in parity-related variables and BMI in younger women. Case-control analyses showed that nulliparity, increasing age at first birth, and obesity in younger women showed the expected associations with the risk of ER(+) or PR(+) tumors but not triple-negative (nulliparity vs parity, odds ratio [OR] = 0.94, 95% confidence interval [CI] = 0.75 to 1.19, P = .61; 5-year increase in age at first full-term birth, OR = 0.95, 95% CI = 0.86 to 1.05, P = .34; obesity in younger women, OR = 1.36, 95% CI = 0.95 to 1.94, P = .09) or CBP tumors.ConclusionsThis study shows that reproductive factors and BMI are most clearly associated with hormone receptor-positive tumors and suggest that triple-negative or CBP tumors may have distinct etiology.
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- 2011
7. Data from 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium
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Warren, Helen, primary, Dudbridge, Frank, primary, Fletcher, Olivia, primary, Orr, Nick, primary, Johnson, Nichola, primary, Hopper, John L., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Mahmoodi, Maryam, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Cornelissen, Sten, primary, Braaf, Linda M., primary, Muir, Kenneth R., primary, Lophatananon, Artitaya, primary, Chaiwerawattana, Arkom, primary, Wiangnon, Surapon, primary, Fasching, Peter A., primary, Beckmann, Matthias W., primary, Ekici, Arif B., primary, Schulz-Wendtland, Ruediger, primary, Sawyer, Elinor J., primary, Tomlinson, Ian, primary, Kerin, Michael, primary, Burwinkel, Barbara, primary, Marme, Frederik, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Laurent-Puig, Pierre, primary, Mulot, Claire, primary, Bojesen, Stig E, primary, Nielsen, Sune F., primary, Flyger, Henrik, primary, Nordestgaard, Børge G, primary, Milne, Roger L., primary, Benítez, Javier, primary, Arias-Pérez, José-Ignacio, primary, Zamora, M. Pilar, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Bernstein, Leslie, primary, Dur, Christina Clarke, primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Langheinz, Anne, primary, Meindl, Alfons, primary, Golatta, Michael, primary, Bartram, Claus R., primary, Schmutzler, Rita K., primary, Brauch, Hiltrud, primary, Justenhoven, Christina, primary, Brüning, Thomas, primary, Chang-Claude, Jenny, primary, Wang-Gohrke, Shan, primary, Eilber, Ursula, primary, Dörk, Thilo, primary, Schürmann, Peter, primary, Bremer, Michael, primary, Hillemanns, Peter, primary, Nevanlinna, Heli, primary, Muranen, Taru A., primary, Aittomäki, Kristiina, primary, Blomqvist, Carl, primary, Bogdanova, Natalia, primary, Antonenkova, Natalia, primary, Rogov, Yuriy, primary, Bermisheva, Marina, primary, Prokofyeva, Darya, primary, Zinnatullina, Guzel, primary, Khusnutdinova, Elza, primary, Lindblom, Annika, primary, Margolin, Sara, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Kataja, Vesa, primary, Chenevix-Trench, Georgia, primary, Beesley, Jonathan, primary, Chen, Xiaoqing, primary, Lambrechts, Diether, primary, Smeets, Ann, primary, Paridaens, Robert, primary, Weltens, Caroline, primary, Flesch-Janys, Dieter, primary, Buck, Katharina, primary, Behrens, Sabine, primary, Peterlongo, Paolo, primary, Bernard, Loris, primary, Manoukian, Siranoush, primary, Radice, Paolo, primary, Couch, Fergus J., primary, Vachon, Celine, primary, Wang, Xianshu, primary, Olson, Janet, primary, Giles, Graham, primary, Baglietto, Laura, primary, McLean, Cariona A., primary, Severi, Gianluca, primary, John, Esther M., primary, Miron, Alexander, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Mulligan, Anna Marie, primary, Weerasooriya, Nayana, primary, Devilee, Peter, primary, Tollenaar, Robert A.E.M., primary, Martens, John W.M., primary, Seynaeve, Caroline M., primary, Hooning, Maartje J., primary, Hollestelle, Antoinette, primary, Jager, Agnes, primary, Tilanus-Linthorst, Madeleine M.A., primary, Hall, Per, primary, Czene, Kamila, primary, Liu, Jianjun, primary, Li, Jingmei, primary, Cox, Angela, primary, Cross, Simon S., primary, Brock, Ian W., primary, Reed, Malcolm W.R., primary, Pharoah, Paul, primary, Blows, Fiona M., primary, Dunning, Alison M., primary, Ghoussaini, Maya, primary, Ashworth, Alan, primary, Swerdlow, Anthony, primary, Jones, Michael, primary, Schoemaker, Minouk, primary, Easton, Douglas F., primary, Humphreys, Manjeet, primary, Wang, Qin, primary, Peto, Julian, primary, and dos-Santos-Silva, Isabel, primary
- Published
- 2023
- Full Text
- View/download PDF
8. Supplementary Table 3 from 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium
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Warren, Helen, primary, Dudbridge, Frank, primary, Fletcher, Olivia, primary, Orr, Nick, primary, Johnson, Nichola, primary, Hopper, John L., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Mahmoodi, Maryam, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Cornelissen, Sten, primary, Braaf, Linda M., primary, Muir, Kenneth R., primary, Lophatananon, Artitaya, primary, Chaiwerawattana, Arkom, primary, Wiangnon, Surapon, primary, Fasching, Peter A., primary, Beckmann, Matthias W., primary, Ekici, Arif B., primary, Schulz-Wendtland, Ruediger, primary, Sawyer, Elinor J., primary, Tomlinson, Ian, primary, Kerin, Michael, primary, Burwinkel, Barbara, primary, Marme, Frederik, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Laurent-Puig, Pierre, primary, Mulot, Claire, primary, Bojesen, Stig E, primary, Nielsen, Sune F., primary, Flyger, Henrik, primary, Nordestgaard, Børge G, primary, Milne, Roger L., primary, Benítez, Javier, primary, Arias-Pérez, José-Ignacio, primary, Zamora, M. Pilar, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Bernstein, Leslie, primary, Dur, Christina Clarke, primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Langheinz, Anne, primary, Meindl, Alfons, primary, Golatta, Michael, primary, Bartram, Claus R., primary, Schmutzler, Rita K., primary, Brauch, Hiltrud, primary, Justenhoven, Christina, primary, Brüning, Thomas, primary, Chang-Claude, Jenny, primary, Wang-Gohrke, Shan, primary, Eilber, Ursula, primary, Dörk, Thilo, primary, Schürmann, Peter, primary, Bremer, Michael, primary, Hillemanns, Peter, primary, Nevanlinna, Heli, primary, Muranen, Taru A., primary, Aittomäki, Kristiina, primary, Blomqvist, Carl, primary, Bogdanova, Natalia, primary, Antonenkova, Natalia, primary, Rogov, Yuriy, primary, Bermisheva, Marina, primary, Prokofyeva, Darya, primary, Zinnatullina, Guzel, primary, Khusnutdinova, Elza, primary, Lindblom, Annika, primary, Margolin, Sara, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Kataja, Vesa, primary, Chenevix-Trench, Georgia, primary, Beesley, Jonathan, primary, Chen, Xiaoqing, primary, Lambrechts, Diether, primary, Smeets, Ann, primary, Paridaens, Robert, primary, Weltens, Caroline, primary, Flesch-Janys, Dieter, primary, Buck, Katharina, primary, Behrens, Sabine, primary, Peterlongo, Paolo, primary, Bernard, Loris, primary, Manoukian, Siranoush, primary, Radice, Paolo, primary, Couch, Fergus J., primary, Vachon, Celine, primary, Wang, Xianshu, primary, Olson, Janet, primary, Giles, Graham, primary, Baglietto, Laura, primary, McLean, Cariona A., primary, Severi, Gianluca, primary, John, Esther M., primary, Miron, Alexander, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Mulligan, Anna Marie, primary, Weerasooriya, Nayana, primary, Devilee, Peter, primary, Tollenaar, Robert A.E.M., primary, Martens, John W.M., primary, Seynaeve, Caroline M., primary, Hooning, Maartje J., primary, Hollestelle, Antoinette, primary, Jager, Agnes, primary, Tilanus-Linthorst, Madeleine M.A., primary, Hall, Per, primary, Czene, Kamila, primary, Liu, Jianjun, primary, Li, Jingmei, primary, Cox, Angela, primary, Cross, Simon S., primary, Brock, Ian W., primary, Reed, Malcolm W.R., primary, Pharoah, Paul, primary, Blows, Fiona M., primary, Dunning, Alison M., primary, Ghoussaini, Maya, primary, Ashworth, Alan, primary, Swerdlow, Anthony, primary, Jones, Michael, primary, Schoemaker, Minouk, primary, Easton, Douglas F., primary, Humphreys, Manjeet, primary, Wang, Qin, primary, Peto, Julian, primary, and dos-Santos-Silva, Isabel, primary
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- 2023
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9. Supplementary Table 2 from 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium
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Warren, Helen, primary, Dudbridge, Frank, primary, Fletcher, Olivia, primary, Orr, Nick, primary, Johnson, Nichola, primary, Hopper, John L., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Mahmoodi, Maryam, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Cornelissen, Sten, primary, Braaf, Linda M., primary, Muir, Kenneth R., primary, Lophatananon, Artitaya, primary, Chaiwerawattana, Arkom, primary, Wiangnon, Surapon, primary, Fasching, Peter A., primary, Beckmann, Matthias W., primary, Ekici, Arif B., primary, Schulz-Wendtland, Ruediger, primary, Sawyer, Elinor J., primary, Tomlinson, Ian, primary, Kerin, Michael, primary, Burwinkel, Barbara, primary, Marme, Frederik, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Laurent-Puig, Pierre, primary, Mulot, Claire, primary, Bojesen, Stig E, primary, Nielsen, Sune F., primary, Flyger, Henrik, primary, Nordestgaard, Børge G, primary, Milne, Roger L., primary, Benítez, Javier, primary, Arias-Pérez, José-Ignacio, primary, Zamora, M. Pilar, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Bernstein, Leslie, primary, Dur, Christina Clarke, primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Langheinz, Anne, primary, Meindl, Alfons, primary, Golatta, Michael, primary, Bartram, Claus R., primary, Schmutzler, Rita K., primary, Brauch, Hiltrud, primary, Justenhoven, Christina, primary, Brüning, Thomas, primary, Chang-Claude, Jenny, primary, Wang-Gohrke, Shan, primary, Eilber, Ursula, primary, Dörk, Thilo, primary, Schürmann, Peter, primary, Bremer, Michael, primary, Hillemanns, Peter, primary, Nevanlinna, Heli, primary, Muranen, Taru A., primary, Aittomäki, Kristiina, primary, Blomqvist, Carl, primary, Bogdanova, Natalia, primary, Antonenkova, Natalia, primary, Rogov, Yuriy, primary, Bermisheva, Marina, primary, Prokofyeva, Darya, primary, Zinnatullina, Guzel, primary, Khusnutdinova, Elza, primary, Lindblom, Annika, primary, Margolin, Sara, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Kataja, Vesa, primary, Chenevix-Trench, Georgia, primary, Beesley, Jonathan, primary, Chen, Xiaoqing, primary, Lambrechts, Diether, primary, Smeets, Ann, primary, Paridaens, Robert, primary, Weltens, Caroline, primary, Flesch-Janys, Dieter, primary, Buck, Katharina, primary, Behrens, Sabine, primary, Peterlongo, Paolo, primary, Bernard, Loris, primary, Manoukian, Siranoush, primary, Radice, Paolo, primary, Couch, Fergus J., primary, Vachon, Celine, primary, Wang, Xianshu, primary, Olson, Janet, primary, Giles, Graham, primary, Baglietto, Laura, primary, McLean, Cariona A., primary, Severi, Gianluca, primary, John, Esther M., primary, Miron, Alexander, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Mulligan, Anna Marie, primary, Weerasooriya, Nayana, primary, Devilee, Peter, primary, Tollenaar, Robert A.E.M., primary, Martens, John W.M., primary, Seynaeve, Caroline M., primary, Hooning, Maartje J., primary, Hollestelle, Antoinette, primary, Jager, Agnes, primary, Tilanus-Linthorst, Madeleine M.A., primary, Hall, Per, primary, Czene, Kamila, primary, Liu, Jianjun, primary, Li, Jingmei, primary, Cox, Angela, primary, Cross, Simon S., primary, Brock, Ian W., primary, Reed, Malcolm W.R., primary, Pharoah, Paul, primary, Blows, Fiona M., primary, Dunning, Alison M., primary, Ghoussaini, Maya, primary, Ashworth, Alan, primary, Swerdlow, Anthony, primary, Jones, Michael, primary, Schoemaker, Minouk, primary, Easton, Douglas F., primary, Humphreys, Manjeet, primary, Wang, Qin, primary, Peto, Julian, primary, and dos-Santos-Silva, Isabel, primary
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10. Supplementary Table Legend from 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium
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Warren, Helen, primary, Dudbridge, Frank, primary, Fletcher, Olivia, primary, Orr, Nick, primary, Johnson, Nichola, primary, Hopper, John L., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Mahmoodi, Maryam, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Cornelissen, Sten, primary, Braaf, Linda M., primary, Muir, Kenneth R., primary, Lophatananon, Artitaya, primary, Chaiwerawattana, Arkom, primary, Wiangnon, Surapon, primary, Fasching, Peter A., primary, Beckmann, Matthias W., primary, Ekici, Arif B., primary, Schulz-Wendtland, Ruediger, primary, Sawyer, Elinor J., primary, Tomlinson, Ian, primary, Kerin, Michael, primary, Burwinkel, Barbara, primary, Marme, Frederik, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Laurent-Puig, Pierre, primary, Mulot, Claire, primary, Bojesen, Stig E, primary, Nielsen, Sune F., primary, Flyger, Henrik, primary, Nordestgaard, Børge G, primary, Milne, Roger L., primary, Benítez, Javier, primary, Arias-Pérez, José-Ignacio, primary, Zamora, M. Pilar, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Bernstein, Leslie, primary, Dur, Christina Clarke, primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Langheinz, Anne, primary, Meindl, Alfons, primary, Golatta, Michael, primary, Bartram, Claus R., primary, Schmutzler, Rita K., primary, Brauch, Hiltrud, primary, Justenhoven, Christina, primary, Brüning, Thomas, primary, Chang-Claude, Jenny, primary, Wang-Gohrke, Shan, primary, Eilber, Ursula, primary, Dörk, Thilo, primary, Schürmann, Peter, primary, Bremer, Michael, primary, Hillemanns, Peter, primary, Nevanlinna, Heli, primary, Muranen, Taru A., primary, Aittomäki, Kristiina, primary, Blomqvist, Carl, primary, Bogdanova, Natalia, primary, Antonenkova, Natalia, primary, Rogov, Yuriy, primary, Bermisheva, Marina, primary, Prokofyeva, Darya, primary, Zinnatullina, Guzel, primary, Khusnutdinova, Elza, primary, Lindblom, Annika, primary, Margolin, Sara, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Kataja, Vesa, primary, Chenevix-Trench, Georgia, primary, Beesley, Jonathan, primary, Chen, Xiaoqing, primary, Lambrechts, Diether, primary, Smeets, Ann, primary, Paridaens, Robert, primary, Weltens, Caroline, primary, Flesch-Janys, Dieter, primary, Buck, Katharina, primary, Behrens, Sabine, primary, Peterlongo, Paolo, primary, Bernard, Loris, primary, Manoukian, Siranoush, primary, Radice, Paolo, primary, Couch, Fergus J., primary, Vachon, Celine, primary, Wang, Xianshu, primary, Olson, Janet, primary, Giles, Graham, primary, Baglietto, Laura, primary, McLean, Cariona A., primary, Severi, Gianluca, primary, John, Esther M., primary, Miron, Alexander, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Mulligan, Anna Marie, primary, Weerasooriya, Nayana, primary, Devilee, Peter, primary, Tollenaar, Robert A.E.M., primary, Martens, John W.M., primary, Seynaeve, Caroline M., primary, Hooning, Maartje J., primary, Hollestelle, Antoinette, primary, Jager, Agnes, primary, Tilanus-Linthorst, Madeleine M.A., primary, Hall, Per, primary, Czene, Kamila, primary, Liu, Jianjun, primary, Li, Jingmei, primary, Cox, Angela, primary, Cross, Simon S., primary, Brock, Ian W., primary, Reed, Malcolm W.R., primary, Pharoah, Paul, primary, Blows, Fiona M., primary, Dunning, Alison M., primary, Ghoussaini, Maya, primary, Ashworth, Alan, primary, Swerdlow, Anthony, primary, Jones, Michael, primary, Schoemaker, Minouk, primary, Easton, Douglas F., primary, Humphreys, Manjeet, primary, Wang, Qin, primary, Peto, Julian, primary, and dos-Santos-Silva, Isabel, primary
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- 2023
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11. Supplementary Table 1 from 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium
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Warren, Helen, primary, Dudbridge, Frank, primary, Fletcher, Olivia, primary, Orr, Nick, primary, Johnson, Nichola, primary, Hopper, John L., primary, Apicella, Carmel, primary, Southey, Melissa C., primary, Mahmoodi, Maryam, primary, Schmidt, Marjanka K., primary, Broeks, Annegien, primary, Cornelissen, Sten, primary, Braaf, Linda M., primary, Muir, Kenneth R., primary, Lophatananon, Artitaya, primary, Chaiwerawattana, Arkom, primary, Wiangnon, Surapon, primary, Fasching, Peter A., primary, Beckmann, Matthias W., primary, Ekici, Arif B., primary, Schulz-Wendtland, Ruediger, primary, Sawyer, Elinor J., primary, Tomlinson, Ian, primary, Kerin, Michael, primary, Burwinkel, Barbara, primary, Marme, Frederik, primary, Schneeweiss, Andreas, primary, Sohn, Christof, primary, Guénel, Pascal, primary, Truong, Thérèse, primary, Laurent-Puig, Pierre, primary, Mulot, Claire, primary, Bojesen, Stig E, primary, Nielsen, Sune F., primary, Flyger, Henrik, primary, Nordestgaard, Børge G, primary, Milne, Roger L., primary, Benítez, Javier, primary, Arias-Pérez, José-Ignacio, primary, Zamora, M. Pilar, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Bernstein, Leslie, primary, Dur, Christina Clarke, primary, Brenner, Hermann, primary, Müller, Heiko, primary, Arndt, Volker, primary, Langheinz, Anne, primary, Meindl, Alfons, primary, Golatta, Michael, primary, Bartram, Claus R., primary, Schmutzler, Rita K., primary, Brauch, Hiltrud, primary, Justenhoven, Christina, primary, Brüning, Thomas, primary, Chang-Claude, Jenny, primary, Wang-Gohrke, Shan, primary, Eilber, Ursula, primary, Dörk, Thilo, primary, Schürmann, Peter, primary, Bremer, Michael, primary, Hillemanns, Peter, primary, Nevanlinna, Heli, primary, Muranen, Taru A., primary, Aittomäki, Kristiina, primary, Blomqvist, Carl, primary, Bogdanova, Natalia, primary, Antonenkova, Natalia, primary, Rogov, Yuriy, primary, Bermisheva, Marina, primary, Prokofyeva, Darya, primary, Zinnatullina, Guzel, primary, Khusnutdinova, Elza, primary, Lindblom, Annika, primary, Margolin, Sara, primary, Mannermaa, Arto, primary, Kosma, Veli-Matti, primary, Hartikainen, Jaana M., primary, Kataja, Vesa, primary, Chenevix-Trench, Georgia, primary, Beesley, Jonathan, primary, Chen, Xiaoqing, primary, Lambrechts, Diether, primary, Smeets, Ann, primary, Paridaens, Robert, primary, Weltens, Caroline, primary, Flesch-Janys, Dieter, primary, Buck, Katharina, primary, Behrens, Sabine, primary, Peterlongo, Paolo, primary, Bernard, Loris, primary, Manoukian, Siranoush, primary, Radice, Paolo, primary, Couch, Fergus J., primary, Vachon, Celine, primary, Wang, Xianshu, primary, Olson, Janet, primary, Giles, Graham, primary, Baglietto, Laura, primary, McLean, Cariona A., primary, Severi, Gianluca, primary, John, Esther M., primary, Miron, Alexander, primary, Winqvist, Robert, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Grip, Mervi, primary, Andrulis, Irene L., primary, Knight, Julia A., primary, Mulligan, Anna Marie, primary, Weerasooriya, Nayana, primary, Devilee, Peter, primary, Tollenaar, Robert A.E.M., primary, Martens, John W.M., primary, Seynaeve, Caroline M., primary, Hooning, Maartje J., primary, Hollestelle, Antoinette, primary, Jager, Agnes, primary, Tilanus-Linthorst, Madeleine M.A., primary, Hall, Per, primary, Czene, Kamila, primary, Liu, Jianjun, primary, Li, Jingmei, primary, Cox, Angela, primary, Cross, Simon S., primary, Brock, Ian W., primary, Reed, Malcolm W.R., primary, Pharoah, Paul, primary, Blows, Fiona M., primary, Dunning, Alison M., primary, Ghoussaini, Maya, primary, Ashworth, Alan, primary, Swerdlow, Anthony, primary, Jones, Michael, primary, Schoemaker, Minouk, primary, Easton, Douglas F., primary, Humphreys, Manjeet, primary, Wang, Qin, primary, Peto, Julian, primary, and dos-Santos-Silva, Isabel, primary
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- 2023
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12. Data from Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer
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Stevens, Kristen N., primary, Vachon, Celine M., primary, Lee, Adam M., primary, Slager, Susan, primary, Lesnick, Timothy, primary, Olswold, Curtis, primary, Fasching, Peter A., primary, Miron, Penelope, primary, Eccles, Diana, primary, Carpenter, Jane E., primary, Godwin, Andrew K., primary, Ambrosone, Christine, primary, Winqvist, Robert, primary, Brauch, Hiltrud, primary, Schmidt, Marjanka K., primary, Cox, Angela, primary, Cross, Simon S., primary, Sawyer, Elinor, primary, Hartmann, Arndt, primary, Beckmann, Matthias W., primary, Schulz-Wendtland, Rüdiger, primary, Ekici, Arif B., primary, Tapper, William J., primary, Gerty, Susan M., primary, Durcan, Lorraine, primary, Graham, Nikki, primary, Hein, Rebecca, primary, Nickels, Stephan, primary, Flesch-Janys, Dieter, primary, Heinz, Judith, primary, Sinn, Hans-Peter, primary, Konstantopoulou, Irene, primary, Fostira, Florentia, primary, Pectasides, Dimitrios, primary, Dimopoulos, Athanasios M., primary, Fountzilas, George, primary, Clarke, Christine L., primary, Balleine, Rosemary, primary, Olson, Janet E., primary, Fredericksen, Zachary, primary, Diasio, Robert B., primary, Pathak, Harsh, primary, Ross, Eric, primary, Weaver, JoEllen, primary, Rüdiger, Thomas, primary, Försti, Asta, primary, Dünnebier, Thomas, primary, Ademuyiwa, Foluso, primary, Kulkarni, Swati, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Ko, Yon-Dschun, primary, Van Limbergen, Erik, primary, Janssen, Hilde, primary, Peto, Julian, primary, Fletcher, Olivia, primary, Giles, Graham G., primary, Baglietto, Laura, primary, Verhoef, Senno, primary, Tomlinson, Ian, primary, Kosma, Veli-Matti, primary, Beesley, Jonathan, primary, Greco, Dario, primary, Blomqvist, Carl, primary, Irwanto, Astrid, primary, Liu, Jianjun, primary, Blows, Fiona M., primary, Dawson, Sarah-Jane, primary, Margolin, Sara, primary, Mannermaa, Arto, primary, Martin, Nicholas G., primary, Montgomery, Grant W., primary, Lambrechts, Diether, primary, dos Santos Silva, Isabel, primary, Severi, Gianluca, primary, Hamann, Ute, primary, Pharoah, Paul, primary, Easton, Douglas F., primary, Chang-Claude, Jenny, primary, Yannoukakos, Drakoulis, primary, Nevanlinna, Heli, primary, Wang, Xianshu, primary, and Couch, Fergus J., primary
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- 2023
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13. Supplementary Materials and Methods, Tables 1-5 from Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer
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Stevens, Kristen N., primary, Vachon, Celine M., primary, Lee, Adam M., primary, Slager, Susan, primary, Lesnick, Timothy, primary, Olswold, Curtis, primary, Fasching, Peter A., primary, Miron, Penelope, primary, Eccles, Diana, primary, Carpenter, Jane E., primary, Godwin, Andrew K., primary, Ambrosone, Christine, primary, Winqvist, Robert, primary, Brauch, Hiltrud, primary, Schmidt, Marjanka K., primary, Cox, Angela, primary, Cross, Simon S., primary, Sawyer, Elinor, primary, Hartmann, Arndt, primary, Beckmann, Matthias W., primary, Schulz-Wendtland, Rüdiger, primary, Ekici, Arif B., primary, Tapper, William J., primary, Gerty, Susan M., primary, Durcan, Lorraine, primary, Graham, Nikki, primary, Hein, Rebecca, primary, Nickels, Stephan, primary, Flesch-Janys, Dieter, primary, Heinz, Judith, primary, Sinn, Hans-Peter, primary, Konstantopoulou, Irene, primary, Fostira, Florentia, primary, Pectasides, Dimitrios, primary, Dimopoulos, Athanasios M., primary, Fountzilas, George, primary, Clarke, Christine L., primary, Balleine, Rosemary, primary, Olson, Janet E., primary, Fredericksen, Zachary, primary, Diasio, Robert B., primary, Pathak, Harsh, primary, Ross, Eric, primary, Weaver, JoEllen, primary, Rüdiger, Thomas, primary, Försti, Asta, primary, Dünnebier, Thomas, primary, Ademuyiwa, Foluso, primary, Kulkarni, Swati, primary, Pylkäs, Katri, primary, Jukkola-Vuorinen, Arja, primary, Ko, Yon-Dschun, primary, Van Limbergen, Erik, primary, Janssen, Hilde, primary, Peto, Julian, primary, Fletcher, Olivia, primary, Giles, Graham G., primary, Baglietto, Laura, primary, Verhoef, Senno, primary, Tomlinson, Ian, primary, Kosma, Veli-Matti, primary, Beesley, Jonathan, primary, Greco, Dario, primary, Blomqvist, Carl, primary, Irwanto, Astrid, primary, Liu, Jianjun, primary, Blows, Fiona M., primary, Dawson, Sarah-Jane, primary, Margolin, Sara, primary, Mannermaa, Arto, primary, Martin, Nicholas G., primary, Montgomery, Grant W., primary, Lambrechts, Diether, primary, dos Santos Silva, Isabel, primary, Severi, Gianluca, primary, Hamann, Ute, primary, Pharoah, Paul, primary, Easton, Douglas F., primary, Chang-Claude, Jenny, primary, Yannoukakos, Drakoulis, primary, Nevanlinna, Heli, primary, Wang, Xianshu, primary, and Couch, Fergus J., primary
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- 2023
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14. Incorporating progesterone receptor expression into the PREDICT breast prognostic model
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Grootes, Isabelle, primary, Keeman, Renske, additional, Blows, Fiona M., additional, Milne, Roger L., additional, Giles, Graham G., additional, Swerdlow, Anthony J., additional, Fasching, Peter A., additional, Abubakar, Mustapha, additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Beckmann, Matthias W., additional, Blomqvist, Carl, additional, Bojesen, Stig E., additional, Bolla, Manjeet K., additional, Bonanni, Bernardo, additional, Briceno, Ignacio, additional, Burwinkel, Barbara, additional, Camp, Nicola J., additional, Castelao, Jose E., additional, Choi, Ji-Yeob, additional, Clarke, Christine L., additional, Couch, Fergus J., additional, Cox, Angela, additional, Cross, Simon S., additional, Czene, Kamila, additional, Devilee, Peter, additional, Dörk, Thilo, additional, Dunning, Alison M., additional, Dwek, Miriam, additional, Easton, Douglas F., additional, Eccles, Diana M., additional, Eriksson, Mikael, additional, Ernst, Kristina, additional, Evans, D. Gareth, additional, Figueroa, Jonine D., additional, Fink, Visnja, additional, Floris, Giuseppe, additional, Fox, Stephen, additional, Gabrielson, Marike, additional, Gago-Dominguez, Manuela, additional, García-Sáenz, José A., additional, González-Neira, Anna, additional, Haeberle, Lothar, additional, Haiman, Christopher A., additional, Hall, Per, additional, Hamann, Ute, additional, Harkness, Elaine F., additional, Hartman, Mikael, additional, Hein, Alexander, additional, Hooning, Maartje J., additional, Hou, Ming-Feng, additional, Howell, Sacha J., additional, Ito, Hidemi, additional, Jakubowska, Anna, additional, Janni, Wolfgang, additional, John, Esther M., additional, Jung, Audrey, additional, Kang, Daehee, additional, Kristensen, Vessela N., additional, Kwong, Ava, additional, Lambrechts, Diether, additional, Li, Jingmei, additional, Lubiński, Jan, additional, Manoochehri, Mehdi, additional, Margolin, Sara, additional, Matsuo, Keitaro, additional, Taib, Nur Aishah Mohd, additional, Mulligan, Anna Marie, additional, Nevanlinna, Heli, additional, Newman, William G., additional, Offit, Kenneth, additional, Osorio, Ana, additional, Park, Sue K., additional, Park-Simon, Tjoung-Won, additional, Patel, Alpa V., additional, Presneau, Nadege, additional, Pylkäs, Katri, additional, Rack, Brigitte, additional, Radice, Paolo, additional, Rennert, Gad, additional, Romero, Atocha, additional, Saloustros, Emmanouil, additional, Sawyer, Elinor J., additional, Schneeweiss, Andreas, additional, Schochter, Fabienne, additional, Schoemaker, Minouk J., additional, Shen, Chen-Yang, additional, Shibli, Rana, additional, Sinn, Peter, additional, Tapper, William J., additional, Tawfiq, Essa, additional, Teo, Soo Hwang, additional, Teras, Lauren R., additional, Torres, Diana, additional, Vachon, Celine M., additional, van Deurzen, Carolien H.M., additional, Wendt, Camilla, additional, Williams, Justin A., additional, Winqvist, Robert, additional, Elwood, Mark, additional, Schmidt, Marjanka K., additional, García-Closas, Montserrat, additional, and Pharoah, Paul D.P., additional
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- 2022
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15. Breast cancer susceptibility risk associations and heterogeneity by E-cadherin tumor tissue expression
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Horne, Hisani N., Sherman, Mark E., Garcia-Closas, Montserrat, Pharoah, Paul D., Blows, Fiona M., Yang, Xiaohong R., Hewitt, Stephen M., Conway, Catherine M., Lissowska, Jolanta, Brinton, Louise A., Prokunina-Olsson, Ludmila, Dawson, Sarah-Jane, Caldas, Carlos, Easton, Douglas F., Chanock, Stephen J., and Figueroa, Jonine D.
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- 2014
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16. Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk
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Lin, Wei-Yu, Camp, Nicola J., Ghoussaini, Maya, Beesley, Jonathan, Michailidou, Kyriaki, Hopper, John L., Apicella, Carmel, Southey, Melissa C., Stone, Jennifer, Schmidt, Marjanka K., Broeks, Annegien, Vanʼt Veer, Laura J., Th Rutgers, Emiel J., Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter A., Haeberle, Lothar, Ekici, Arif B., Beckmann, Matthias W., Peto, Julian, Dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Sawyer, Elinor J., Cheng, Timothy, Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Marmé, Frederik, Surowy, Harald M., Burwinkel, Barbara, Guénel, Pascal, Truong, Thérèse, Menegaux, Florence, Mulot, Claire, Bojesen, Stig E., Nordestgaard, Børge G., Nielsen, Sune F., Flyger, Henrik, Benitez, Javier, Zamora, M. Pilar, Arias Perez, Jose Ignacio, Menéndez, Primitiva, González-Neira, Anna, Pita, Guillermo, Alonso, M. Rosario, Álvarez, Nuria, Herrero, Daniel, Anton-Culver, Hoda, Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Lichtner, Peter, Schmutzler, Rita K., Müller-Myhsok, Bertram, Brauch, Hiltrud, Brüning, Thomas, Ko, Yon-Dschun, Tessier, Daniel C., Vincent, Daniel, Bacot, Francois, Nevanlinna, Heli, Aittomäki, Kristiina, Blomqvist, Carl, Khan, Sofia, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Horio, Akiyo, Bogdanova, Natalia V., Antonenkova, Natalia N., Dörk, Thilo, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Wu, Anna H., Tseng, Chiu-Chen, Van Den Berg, David, Stram, Daniel O., Neven, Patrick, Wauters, Els, Wildiers, Hans, Lambrechts, Diether, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Manoukian, Siranoush, Bonanni, Bernardo, Couch, Fergus J., Wang, Xianshu, Vachon, Celine, Purrington, Kristen, Giles, Graham G., Milne, Roger L., Mclean, Catriona, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Le Marchand, Loic, Simard, Jacques, Goldberg, Mark S., Labrèche, France, Dumont, Martine, Teo, Soo Hwang, Yip, Cheng Har, Hassan, Norhashimah, Vithana, Eranga Nishanthie, Kristensen, Vessela, Zheng, Wei, Deming-Halverson, Sandra, Shrubsole, Martha J., Long, Jirong, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Kauppila, Saila, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Devilee, Peter, Tollenaar, Robert A.E.M., Seynaeve, Caroline, Van Asperen, Christi J., García-Closas, Montserrat, Figueroa, Jonine, Lissowska, Jolanta, Brinton, Louise, Czene, Kamila, Darabi, Hatef, Eriksson, Mikael, Brand, Judith S., Hooning, Maartje J., Hollestelle, Antoinette, Van Den Ouweland, Ans M.W., Jager, Agnes, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Shu, Xiao-Ou, Lu, Wei, Gao, Yu-Tang, Cai, Hui, Cross, Simon S., Reed, Malcolm W. R., Blot, William, Signorello, Lisa B., Cai, Qiuyin, Pharoah, Paul D.P., Perkins, Barbara, Shah, Mitul, Blows, Fiona M., Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Hartman, Mikael, Miao, Hui, Chia, Kee Seng, Putti, Thomas Choudary, Hamann, Ute, Luccarini, Craig, Baynes, Caroline, Ahmed, Shahana, Maranian, Mel, Healey, Catherine S., Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, Mckay, James, Slager, Susan, Toland, Amanda E., Yannoukakos, Drakoulis, Shen, Chen-Yang, Hsiung, Chia-Ni, Wu, Pei-Ei, Ding, Shian-ling, Ashworth, Alan, Jones, Michael, Orr, Nick, Swerdlow, Anthony J, Tsimiklis, Helen, Makalic, Enes, Schmidt, Daniel F., Bui, Quang M., Chanock, Stephen J., Hunter, David J., Hein, Rebecca, Dahmen, Norbert, Beckmann, Lars, Aaltonen, Kirsimari, Muranen, Taru A., Heikkinen, Tuomas, Irwanto, Astrid, Rahman, Nazneen, Turnbull, Clare A., Waisfisz, Quinten, Meijers-Heijboer, Hanne E. J., Adank, Muriel A., Van Der Luijt, Rob B., Hall, Per, Chenevix-Trench, Georgia, Dunning, Alison, Easton, Douglas F., and Cox, Angela
- Published
- 2015
- Full Text
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17. The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource
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Ryder, Edward, Ashburner, Michael, Bautista-Llacer, Rosa, Drummond, Jenny, Webster, Jane, Johnson, Glynnis, Morley, Terri, Chan, Yuk Sang, Blows, Fiona, Coulson, Darin, Reuter, Gunter, Baisch, Heiko, Apelt, Christian, Kauk, Andreas, Rudolph, Thomas, Kube, Maria, Klimm, Melanie, Nickel, Claudia, Szidonya, Janos, Maroy, Peter, Pal, Margit, Rasmuson-Lestander, Asa, Ekstrom, Karin, Stocker, Hugo, Hugentobler, Christoph, Hafen, Ernst, Gubb, David, Pflugfelder, Gert, Dorner, Christian, Mechler, Bernard, Schenkel, Heide, Marhold, Joachim, Serras, Florenci, Corominas, Montserrat, Punset, Adria, Roote, John, and Russell, Steven
- Subjects
Drosophila -- Genetic aspects ,Chromosome abnormalities -- Diagnosis ,Chromosome mapping -- Research ,Biological sciences - Abstract
We describe a second-generation deficiency kit for Drosophila melanogaster composed of molecularly mapped deletions on an isogenic background, covering ~77% of the Release 5.1 genome. Using a previously reported collection of FRT-bearing P-element insertions, we have generated 655 new deletions and verified a set of 209 deletion-bearing fly stocks. In addition to deletions, we demonstrate how the P elements may also be used to generate a set of custom inversions and duplications, particularly useful for balancing difficult regions of the genome carrying haplo-insufficient loci. We describe a simple computational resource that facilitates selection of appropriate elements for generating custom deletions. Finally, we provide a computational resource that facilitates selection of other mapped FRT-bearing elements that, when combined with the DrosDel collection, can theoretically generate over half a million precisely mapped deletions.
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- 2007
18. The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster
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Ryder, Edward, Blows, Fiona, Ashburner, Michael, Bautista-Llacer, Rosa, Coulson, Darin, Drummond, Jenny, Webster, Jane, Gubb, David, Gunton, Nicola, Johnson, Glynnis, O'Kane, Cahir J., Huen, David, Sharma, Punita, Asztalos, Zoltan, Baisch, Heiko, Schulze, Janet, Kube, Maria, Kittlaus, Kathrin, Reuter, Gunter, Maroy, Peter, Szidonya, Janos, Rasmuson-Lestander, Asa, Ekstrom, Karin, Dickson, Barry, Hugentobler, Christoph, Stocker, Hugo, Hafen, Ernst, Lepesant, Jean Antoine, Pflugfelder, Gert, Heisenberg, Martin, Mechlr, Bernard, Serras, Florenci, Corominas, Montserrat, Schneuwly, Stephan, Preat, Thomas, Roote, John, and Russell, Steven
- Subjects
Chromosomes -- Research ,Drosophila -- Research ,Biological sciences - Abstract
We describe a collection of P-element insertions that have considerable utility for generating custom chromosomal aberrations in Drosophila melanogaster. We have mobilized a pair of engineered P elements, p{RS3} and p{RS5}, to collect 3243 lines unambiguously mapped to the Drosophila genome sequence. The collection contains, on average, an element every 35 kb. We demonstrate the utility of the collection for generating custom chromosomal deletions that have their end points mapped, with base-pair resolution, to the genome sequence. The collection was generated in an isogenic strain, thus affording a uniform background for screens where sensitivity to genetic background is high. The entire collection, along with a computational and genetic toolbox for designing and generating custom deletions, is publicly available. Using the collection it is theoretically possible to generate >12,000 deletions between 1 bp and 1 Mb in size by simple eye color selection. In addition, a further 37,000 deletions, selectable by molecular screening, may be generated. We are now using the collection to generate a second-generation deficiency kit that is precisely mapped to the genome sequence.
- Published
- 2004
19. Biological and prognostic associations of miR-205 and let-7b in breast cancer revealed by in situ hybridization analysis of micro-RNA expression in arrays of archival tumour tissue
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Quesne, John Le, Jones, Julia, Warren, Joanna, Dawson, Sarah-Jane, Ali, H Raza, Bardwell, Helen, Blows, Fiona, Pharoah, Paul, and Caldas, Carlos
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- 2012
- Full Text
- View/download PDF
20. A Ki67/BCL2 index based on immunohistochemistry is highly prognostic in ER-positive breast cancer
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Ali, Raza H, Dawson, Sarah-Jane, Blows, Fiona M, Provenzano, Elena, Leung, Samuel, Nielsen, Torsten, Pharoah, Paul D, and Caldas, Carlos
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- 2012
- Full Text
- View/download PDF
21. Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium
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Broeks, Annegien, Schmidt, Marjanka K., Sherman, Mark E., Couch, Fergus J., Hopper, John L., Dite, Gillian S., Apicella, Carmel, Smith, Letitia D., Hammet, Fleur, Southey, Melissa C., Van ’t Veer, Laura J., de Groot, Renate, Smit, Vincent T.H.B.M., Fasching, Peter A., Beckmann, Matthias W., Jud, Sebastian, Ekici, Arif B., Hartmann, Arndt, Hein, Alexander, Schulz-Wendtland, Ruediger, Burwinkel, Barbara, Marme, Frederik, Schneeweiss, Andreas, Sinn, Hans-Peter, Sohn, Christof, Tchatchou, Sandrine, Bojesen, Stig E., Nordestgaard, Børge G., Flyger, Henrik, Ørsted, David D., Kaur-Knudsen, Diljit, Milne, Roger L., Pérez, Jose I. Arias, Zamora, Pilar, Rodríguez, Primitiva Menéndez, Benítez, Javier, Brauch, Hiltrud, Justenhoven, Christina, Ko, Yon-Dschun, Hamann, Ute, Fischer, Hans-Peter, Brüning, Thomas, Pesch, Beate, Chang-Claude, Jenny, Wang-Gohrke, Shan, Bremer, Michael, Karstens, Johann H., Hillemanns, Peter, Dörk, Thilo, Nevanlinna, Heli A., Heikkinen, Tuomas, Heikkilä, Päivi, Blomqvist, Carl, Aittomäki, Kristiina, Aaltonen, Kirsimari, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kosma, Veli-Matti, Kauppinen, Jaana M., Kataja, Vesa, Auvinen, Päivi, Eskelinen, Matti, Soini, Ylermi, Chenevix-Trench, Georgia, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Holland, Helene, Lambrechts, Diether, Claes, Bart, Vandorpe, Thijs, Neven, Patrick, Wildiers, Hans, Flesch-Janys, Dieter, Hein, Rebecca, Löning, Thomas, Kosel, Matthew, Fredericksen, Zachary S., Wang, Xianshu, Giles, Graham G., Baglietto, Laura, Severi, Gianluca, McLean, Catriona, Haiman, Christopher A., Henderson, Brian E., Le Marchand, Loic, Kolonel, Laurence N., Grenaker Alnæs, Grethe, Kristensen, Vessela, Børresen-Dale, Anne-Lise, Hunter, David J., Hankinson, Susan E., Andrulis, Irene L., Marie Mulligan, Anna, OʼMalley, Frances P., Devilee, Peter, Huijts, Petra E.A., Tollenaar, Rob A.E.M., Van Asperen, Christi J., Seynaeve, Caroline S., Chanock, Stephen J., Lissowska, Jolanta, Brinton, Louise, Peplonska, Beata, Figueroa, Jonine, Yang, Xiaohong R., Hooning, Maartje J., Hollestelle, Antoinette, Oldenburg, Rogier A., Jager, Agnes, Kriege, Mieke, Ozturk, Bahar, van Leenders, Geert J.L.H., Hall, Per, Czene, Kamila, Humphreys, Keith, Liu, Jianjun, Cox, Angela, Connley, Daniel, Cramp, Helen E., Cross, Simon S., Balasubramanian, Sabapathy P., Reed, Malcolm W.R., Dunning, Alison M., Easton, Douglas F., Humphreys, Manjeet K., Caldas, Carlos, Blows, Fiona, Driver, Kristy, Provenzano, Elena, Lubinski, Jan, Jakubowska, Anna, Huzarski, Tomasz, Byrski, Tomasz, Cybulski, Cezary, Gorski, Bohdan, Gronwald, Jacek, Brennan, Paul, Sangrajrang, Suleeporn, Gaborieau, Valerie, Shen, Chen-Yang, Hsiung, Chia-Ni, Yu, Jyh-Cherng, Chen, Shou-Tung, Hsu, Giu-Cheng, Hou, Ming-Feng, Huang, Chiun-Sheng, Anton-Culver, Hoda, Ziogas, Argyrios, Pharoah, Paul D.P., and Garcia-Closas, Montserrat
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- 2011
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22. Regional Differences in the Response of Human Pre-Adipocytes to PPARγ and RXRα Agonists
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Sewter, Ciaran P., Blows, Fiona, Vidal-Puig, Antonio, and O'Rahilly, Stephen
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- 2002
23. Lamin Expression in Human Adipose Cells in Relation to Anatomical Site and Differentiation State
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Lelliott, Christopher J., Logie, Lisa, Sewter, Ciaran P., Berger, Dirk, Jani, Piyush, Blows, Fiona, O’Rahilly, Stephen, and Vidal-Puig, Antonio
- Published
- 2002
24. The Landscape of Somatic Genetic Alterations in Breast Cancers From ATM Germline Mutation Carriers
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Weigelt, Britta, Bi, Rui, Kumar, Rahul, Blecua, Pedro, Mandelker, Diana L, Geyer, Felipe C, Pareja, Fresia, James, Paul A, KConFab Investigators, Couch, Fergus J, Eccles, Diana M, Blows, Fiona, Pharoah, Paul, Li, Anqi, Selenica, Pier, Lim, Raymond S, Jayakumaran, Gowtham, Waddell, Nic, Shen, Ronglai, Norton, Larry, Wen, Hannah Y, Powell, Simon N, Riaz, Nadeem, Robson, Mark E, Reis-Filho, Jorge S, Chenevix-Trench, Georgia, Pharoah, Paul [0000-0001-8494-732X], and Apollo - University of Cambridge Repository
- Subjects
brcal gene ,recombination, genetic ,infiltrates ,phenotype ,protein p53 ,datasets ,hormone receptors ,neoplasms ,dna ,tp53 gene ,ataxia-telangiectasia ,breast cancer ,alleles ,brcal protein ,biopharmaceutics classification system ,loss of heterozygosity ,genetics ,somatic mutation ,dna damage ,cell cycle checkpoint ,mutation ,genes ,germ-line mutation ,exome - Abstract
Pathogenic germline variants in ataxia-telangiectasia mutated (ATM), a gene that plays a role in DNA damage response and cell cycle checkpoints, confer an increased breast cancer (BC) risk. Here, we investigated the phenotypic characteristics and landscape of somatic genetic alterations in 24 BCs from ATM germline mutation carriers by whole-exome and targeted sequencing. ATM-associated BCs were consistently hormone receptor positive and largely displayed minimal immune infiltrate. Although 79.2% of these tumors exhibited loss of heterozygosity of the ATM wild-type allele, none displayed high activity of mutational signature 3 associated with defective homologous recombination DNA (HRD) repair. No TP53 mutations were found in the ATM-associated BCs. Analysis of an independent data set confirmed that germline ATM variants and TP53 somatic mutations are mutually exclusive. Our findings indicate that ATM-associated BCs often harbor bi-allelic inactivation of ATM, are phenotypically distinct from BRCA1/2-associated BCs, lack HRD-related mutational signatures, and that TP53 and ATM genetic alterations are likely epistatic., This work was supported in part by the Meredith Israel Thomas Fund, the Breast Cancer Research Foundation, the Sarah Jenkins Fund, a Cancer Center Support Grant from the National Institutes of Health (NIH)/National Cancer Institute (Grant No. P30CA008748), NIH grants CA192393 and CA176785, and a Sponsored Program of Research Excellence (SPORE) in Breast Cancer (P50 CA116201). GCT is supported by the National Health and Medical Research Council of Australia
- Published
- 2018
25. Abstract 2211: Patient level polygenic risk scores and continuous estrogen receptor expression in breast cancer
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Shetty, Anamay H., primary, Ali, Raza, additional, Blows, Fiona, additional, Caldas, Carlos, additional, Inard, Nicholas, additional, Benítez, Javier, additional, Chang-Claude, Jenny, additional, Chenevix-Trench, Georgia, additional, Couch, Fergus, additional, Cox, Angela, additional, Devilee, Peter, additional, Easton, Douglas, additional, Garcia-Closas, Montserrat, additional, Mannermaa, Arto, additional, Nevanlinna, Heli, additional, Schmidt, Marjanka, additional, and Pharoah, Paul, additional
- Published
- 2018
- Full Text
- View/download PDF
26. Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation
- Author
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Abubakar, Mustapha, primary, Chang‐Claude, Jenny, additional, Ali, H. Raza, additional, Chatterjee, Nilanjan, additional, Coulson, Penny, additional, Daley, Frances, additional, Blows, Fiona, additional, Benitez, Javier, additional, Milne, Roger L., additional, Brenner, Hermann, additional, Stegmaier, Christa, additional, Mannermaa, Arto, additional, Rudolph, Anja, additional, Sinn, Peter, additional, Couch, Fergus J., additional, Devilee, Peter, additional, Tollenaar, Rob A.E.M., additional, Seynaeve, Caroline, additional, Figueroa, Jonine, additional, Lissowska, Jolanta, additional, Hewitt, Stephen, additional, Hooning, Maartje J., additional, Hollestelle, Antoinette, additional, Foekens, Renée, additional, Koppert, Linetta B., additional, Investigators, kConFab, additional, Bolla, Manjeet K., additional, Wang, Qin, additional, Jones, Michael E., additional, Schoemaker, Minouk J., additional, Keeman, Renske, additional, Easton, Douglas F., additional, Swerdlow, Anthony J., additional, Sherman, Mark E., additional, Schmidt, Marjanka K., additional, Pharoah, Paul D., additional, and Garcia‐Closas, Montserrat, additional
- Published
- 2018
- Full Text
- View/download PDF
27. Decline in Antigenicity of Tumor Markers by Storage Time Using Pathology Sections Cut From Tissue Microarrays
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Blows, Fiona M, Ali, Hamid R, Dawson, Sarah-J, Le Quesne, John, Provenzano, Elena, Caldas, Carlos, Pharoah, Paul DP, Ali, Raza [0000-0001-7587-0906], Caldas, Carlos [0000-0003-3547-1489], Pharoah, Paul [0000-0001-8494-732X], and Apollo - University of Cambridge Repository
- Subjects
Tissue Array Analysis ,Neoplasms ,Biomarkers, Tumor ,Humans - Abstract
Sectioning a whole tissue microarrray (TMA block) and storing the sections maximizes the number of sections obtained, but may impair the antigenicity of the stored sections. We have investigated the impact of TMA section storage on antigenicity. First, we reexamined existing TMA data to determine whether antigenicity in stored sections changes over time. Component scores for each marker, based on cellular compartment of staining and score-type, were evaluated separately. Residual components scores adjusted for grade, tumor size, and node positivity, were regressed on the number of days storage to evaluate the effect of storage time. Storage time ranged from 2 to 1897 days, and the mean change in antigenicity per year ranged from -0.88 (95% confidence interval, -1.11 to -0.65) to 0.035 (95% confidence interval, 0.016-0.054). Further analysis showed no significant improvement in the fit of survival models if storage time adjusted scores were included in the models rather than unadjusted scores. We then compared 3 ways of processing TMA sections after cutting-immediate staining, staining after 1 year, and staining after 1 year coated in wax-on the immunohistochemistry results for: progesterone receptor, a routinely used, robust antibody, and MKI67, which is generally considered less robust. The progesterone receptor scores for stored sections were similar to those for unstored sections, whereas the MKI67 scores for stored sections were substantially different to those for unstored sections. Wax coating made little difference to the results. Biomarker antigenicity shows a small decline over time that is unlikely to have an important effect on studies of prognostic biomarkers.
- Published
- 2016
28. Additional file 1: of Prognostic value of automated KI67 scoring in breast cancer: a centralised evaluation of 8088 patients from 10 study groups
- Author
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Abubakar, Mustapha, Orr, Nick, Daley, Frances, Coulson, Penny, H. Ali, Blows, Fiona, Benitez, Javier, Milne, Roger, Brenner, Herman, Stegmaier, Christa, Mannermaa, Arto, Chang-Claude, Jenny, Rudolph, Anja, Sinn, Peter, Couch, Fergus, Devilee, Peter, Tollenaar, Rob, Seynaeve, Caroline, Jonine Figueroa, Sherman, Mark, Lissowska, Jolanta, Hewitt, Stephen, Eccles, Diana, Hooning, Maartje, Hollestelle, Antoinette, Martens, John, Deurzen, Carolien, KConFab Investigators, Bolla, Manjeet, Wang, Qin, Jones, Michael, Minouk Schoemaker, Wesseling, Jelle, Leeuwen, Flora Van, Laura Van ‘T Veer, Easton, Douglas, Swerdlow, Anthony, Dowsett, Mitch, Pharoah, Paul, Marjanka Schmidt, and Garcia-Closas, Montserrat
- Abstract
Is Table S1 presenting a description of study populations, Table S2 presenting KI67 immunohistochemistry reagents and antigen retrieval protocols according to study groups, Table S3 presenting the association of clinical and pathological characteristics with high (>12 %) and low (≤12 %) KI67 categories among 5520 ER-positive breast cancer cases, Table S4 presenting the association of clinical and pathological characteristics with high (>12 %) and low (≤12 %) KI67 categories among 2049 ER-negative breast cancer cases, Table S5 presenting cross-classification of visual and automated KI67 score categories, Table S6 presenting a multivariate model for the association of KI67 with 10-year BCSS among 5520 ER-positive patients, and Table S7 presenting a multivariate model for the association of KI67 with 10-year BCSS among 2049 ER-negative patients. (PDF 237 kb)
- Published
- 2016
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29. TP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer
- Author
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Fagerholm, Rainer, primary, Khan, Sofia, additional, Schmidt, Marjanka K., additional, García-Closas, Montserrat, additional, Heikkilä, Päivi, additional, Saarela, Jani, additional, Beesley, Jonathan, additional, Jamshidi, Maral, additional, Aittomäki, Kristiina, additional, Liu, Jianjun, additional, Ali, H. Raza, additional, Andrulis, Irene L., additional, Beckmann, Matthias W., additional, Behrens, Sabine, additional, Blows, Fiona M., additional, Brenner, Hermann, additional, Chang-Claude, Jenny, additional, Couch, Fergus J., additional, Czene, Kamila, additional, Fasching, Peter A., additional, Figueroa, Jonine, additional, Floris, Giuseppe, additional, Glendon, Gord, additional, Guo, Qi, additional, Hall, Per, additional, Hallberg, Emily, additional, Hamann, Ute, additional, Holleczek, Bernd, additional, Hooning, Maartje J., additional, Hopper, John L., additional, Jager, Agnes, additional, Kabisch, Maria, additional, Investigators, kConFab/AOCS, additional, Keeman, Renske, additional, Kosma, Veli-Matti, additional, Lambrechts, Diether, additional, Lindblom, Annika, additional, Mannermaa, Arto, additional, Margolin, Sara, additional, Provenzano, Elena, additional, Shah, Mitul, additional, Southey, Melissa C., additional, Dennis, Joe, additional, Lush, Michael, additional, Michailidou, Kyriaki, additional, Wang, Qin, additional, Bolla, Manjeet K., additional, Dunning, Alison M., additional, Easton, Douglas F., additional, Pharoah, Paul D.P., additional, Chenevix-Trench, Georgia, additional, Blomqvist, Carl, additional, and Nevanlinna, Heli, additional
- Published
- 2017
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30. Annexin A1 expression in a pooled breast cancer series: Association with tumor subtypes and prognosis
- Author
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Sobral-Leite, Marcelo, Wesseling, Jelle, Smit, Vincent T H B M, Nevanlinna, Heli, van Miltenburg, Martine H., Sanders, Joyce, Hofland, Ingrid, Blows, Fiona M., Coulson, Penny, Patrycja, Gazinska, Schellens, Jan H M, Fagerholm, Rainer, Heikkilä, Päivi, Aittomäki, Kristiina, Blomqvist, Carl, Provenzano, Elena, Ali, Hamid Raza, Figueroa, Jonine, Sherman, Mark, Lissowska, Jolanta, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli Matti, Hartikainen, Jaana M., Phillips, Kelly Anne, Couch, Fergus J., Olson, Janet E., Vachon, Celine, Visscher, Daniel, Brenner, Hermann, Butterbach, Katja, Arndt, Volker, Holleczek, Bernd, Hooning, Maartje J., Hollestelle, Antoinette, Martens, John W M, van Deurzen, Carolien H M, van de Water, Bob, Broeks, Annegien, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Easton, Douglas F., Pharoah, Paul D P, García-Closas, Montserrat, de Graauw, Marjo, Schmidt, Marjanka K., Aghmesheh, Morteza, Amor, David, Andrews, Lesley, Antill, Yoland, Armitage, Shane, Arnold, Leanne, Balleine, Rosemary, Bankier, Agnes, Bastick, Patti, Beesley, Jonathan, Beilby, John, Bennett, Barbara, Bennett, Ian, Berry, Geoffrey, Blackburn, Anneke, Bogwitz, Michael, Brennan, Meagan, Brown, Melissa, Buckley, Michael, Burgess, Matthew, Burke, Jo, Butow, Phyllis, Byron, Keith, Callen, David, Campbell, Ian, Chauhan, Deepa, Chauhan, Manisha, Christian, Alice, Clarke, Christine, Colley, Alison, Cotton, Dick, Crook, Ashley, Cui, James, Culling, Bronwyn, Cummings, Margaret, Dawson, Sarah Jane, deFazio, Anna, Delatycki, Martin, Dickson, Rebecca, Dixon, Joanne, Dobrovic, Alexander, Dudding, Tracy, Edkins, Ted, Edwards, Stacey, Eisenbruch, Maurice, Farshid, Gelareh, Fawcett, Susan, Fellows, Andrew, Fenton, Georgina, Field, Michael, Firgaira, Frank, Flanagan, James, Fleming, Jean, Fong, Peter, Forbes, John, Fox, Stephen, French, Juliet, Friedlander, Michael, Gaff, Clara, Gardner, Mac, Gattas, Mike, George, Peter, Giles, Graham, Gill, Grantley, Goldblatt, Jack, Greening, Sian, Grist, Scott, Haan, Eric, Hardie, Kate, Harris, Marion, Hart, Stewart, Hayward, Nick, Healey, Sue, Heiniger, Louise, Hopper, John, Humphrey, Evelyn, Hunt, Clare, James, Paul, Jenkins, Mark, Jones, Alison, Kefford, Rick, Kidd, Alexa, Kiely, Belinda, Kirk, Judy, Koehler, Jessica, Kollias, James, Kovalenko, Serguei, Lakhani, Sunil, Leaming, Amanda, Leary, Jennifer, Lim, Jacqueline, Lindeman, Geoff, Lipton, Lara, Lobb, Liz, Mann, Graham, Marsh, Deborah, McLachlan, Sue Anne, Meiser, Bettina, Meldrum, Cliff, Milne, Roger, Mitchell, Gillian, Newman, Beth, Niedermayr, Eveline, Nightingale, Sophie, O'Connell, Shona, O'Loughlin, Imelda, Osborne, Richard, Pachter, Nick, Patterson, Briony, Peters, Lester, Phillips, Kelly, Price, Melanie, Purser, Lynne, Reeve, Tony, Reeve, Jeanne, Richards, Robert, Rickard, Edwina, Robinson, Bridget, Rudzki, Barney, Saleh, Mona, Salisbury, Elizabeth, Sambrook, Joe, Saunders, Christobel, Saunus, Jodi, Sayer, Robyn, Scott, Elizabeth, Scott, Rodney, Scott, Clare, Seshadri, Ram, Sexton, Adrienne, Sharma, Raghwa, Shelling, Andrew, Simpson, Peter, Southey, Melissa, Spurdle, Amanda, Suthers, Graeme, Sykes, Pamela, Tassell, Margaret, Taylor, Donna, Taylor, Jessica, Thierry, Benjamin, Thomas, Susan, Thompson, Ella, Thorne, Heather, Townshend, Sharron, Trainer, Alison, Tran, Lan, Tucker, Kathy, Tyler, Janet, Visvader, Jane, Walker, Logan, Walpole, Ian, Ward, Robin, Waring, Paul, Warner, Bev, Warren, Graham, Williams, Rachael, Wilson, Judy, Winship, Ingrid, Wu, Kathy, Young, Mary Ann, Bowtell, D., Green, A., Webb, P., de Fazio, A., Gertig, D., Pharmacoepidemiology and Clinical Pharmacology, Sub Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, and Sub Clinical Pharmacology
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Medicine(all) ,endocrine system ,Breast cancer ,skin and connective tissue diseases ,Annexin A1 ,BRCA1 and BRCA2 mutations - Abstract
Background: Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors. However, little is known about the prognostic value of ANXA1 in breast cancer. The purpose of this study is to evaluate the association between ANXA1 expression, BRCA1/2 germline carriership, specific tumor subtypes and survival in breast cancer patients. Methods: Clinical-pathological information and follow-up data were collected from nine breast cancer studies from the Breast Cancer Association Consortium (BCAC) (n = 5,752) and from one study of familial breast cancer patients with BRCA1/2
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- 2015
31. Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer
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Candido Dos Reis, Francisco J, Lynn, Stuart, Ali, H Raza, Eccles, Diana, Hanby, Andrew, Provenzano, Elena, Caldas, Carlos, Howat, William J, McDuffus, Leigh-Anne, Liu, Bin, Daley, Frances, Coulson, Penny, Vyas, Rupesh J, Harris, Leslie M, Owens, Joanna M, Carton, Amy F M, McQuillan, Janette P, Paterson, Andy M, Hirji, Zohra, Christie, Sarah K, Holmes, Amber R, Schmidt, Marjanka K, Garcia-Closas, Montserrat, Easton, Douglas F, Bolla, Manjeet K, Wang, Qin, Milne, Roger L, Mannermaa, Arto, Couch, Fergus, Devilee, Peter, Tollenaar, Robert A E M, Seynaeve, Caroline, Cox, Angela, Cross, Simon S, Blows, Fiona M, Sanders, Joyce, de Groot, Renate, Figueroa, Jonine, Sherman, Mark, Hooning, Maartje, Brenner, Hermann, Holleczek, Bernd, Stegmaier, Christa, Lintott, Chris, Pharoah, Paul D P, Cancer Research UK (Reino Unido), KWF Kankerbestrijding, NIHR - Bristol Biomedical Research Centre (Reino Unido), and Instituto de Salud Carlos III
- Subjects
BIOMARKER ,Estrogen-receptor ,Breast Neoplasms ,Kaplan-Meier Estimate ,Immunohistochemistry ,Association ,Breast cancer ,ROC Curve ,Receptors, Estrogen ,Missing Data ,Tissue Microarrays ,SURVIVAL ,Crowdsourcing ,Humans ,Female ,Pathology, Molecular ,Proportional Hazards Models - Abstract
Citizen science, scientific research conducted by non-specialists, has the potential to facilitate biomedical research using available large-scale data, however validating the results is challenging. The Cell Slider is a citizen science project that intends to share images from tumors with the general public, enabling them to score tumor markers independently through an internet-based interface. From October 2012 to June 2014, 98,293 Citizen Scientists accessed the Cell Slider web page and scored 180,172 sub-images derived from images of 12,326 tissue microarray cores labeled for estrogen receptor (ER). We evaluated the accuracy of Citizen Scientist's ER classification, and the association between ER status and prognosis by comparing their test performance against trained pathologists. The area under ROC curve was 0.95 (95% CI 0.94 to 0.96) for cancer cell identification and 0.97 (95% CI 0.96 to 0.97) for ER status. ER positive tumors scored by Citizen Scientists were associated with survival in a similar way to that scored by trained pathologists. Survival probability at 15 years were 0.78 (95% CI 0.76 to 0.80) for ER-positive and 0.72 (95% CI 0.68 to 0.77) for ER-negative tumors based on Citizen Scientists classification. Based on pathologist classification, survival probability was 0.79 (95% CI 0.77 to 0.81) for ER-positive and 0.71 (95% CI 0.67 to 0.74) for ER-negative tumors. The hazard ratio for death was 0.26 (95% CI 0.18 to 0.37) at diagnosis and became greater than one after 6.5 years of follow-up for ER scored by Citizen Scientists, and 0.24 (95% CI 0.18 to 0.33) at diagnosis increasing thereafter to one after 6.7 (95% CI 4.1 to 10.9) years of follow-up for ER scored by pathologists. Crowdsourcing of the general public to classify cancer pathology data for research is viable, engages the public and provides accurate ER data. Crowdsourced classification of research data may offer a valid solution to problems of throughput requiring human input. Cell Slider is supported by funding from Cancer Research UK. The individual studies were supported by grants from: Cancer Research UK (C490/A10124, C490/A16561), Dutch Cancer Society (NKI 2007-3839 and 2009-4363), the NIHR Biomedical Research Centre at the University of Cambridge, Yorkshire Cancer Research (S295, S299, S305PA), Red Tematica de Investigacion Cooperativa en Cancer, Fondo de Investigacion Sanitario (PI11/00923 and PI081120). The Human Genotyping-CEGEN Unit (CNIO) is supported by the Instituto de Salud Carlos III and the ESTHER study was supported by the Baden Wurttemberg Ministry of Science, Research and Arts. Sí
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- 2015
32. Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium
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Howat, William J., Blows, Fiona M., Provenzano, Elena, and Menéndez Rodríguez, María Primitiva
- Abstract
Howat, W.J., Blows, F.M., Provenzano, E., Brook, M.N., Morris, L., Gazinska, P., Johnson, N., McDuffus, L.-A., Miller, J., Sawyer, E.J., Pinder, S., van Deurzen, C.H.M., Jones, L., Sironen, R., Visscher, D., Caldas, C., Daley, F., Coulson, P., Broeks, A., Sanders, J., Wesseling, J., Nevanlinna, H., Fagerholm, R., Blomqvist, C., Heikkilä, P., Ali, H.R., Dawson, S.-J., Figueroa, J., Lissowska, J., Brinton, L., Mannermaa, A., Kataja, V., Kosma, V.-M., Cox, A., Brock, I.W., Cross, S.S., Reed, M.W., Couch, F.J., Olson, J.E., Devillee, P., Mesker, W.E., Seyaneve, C.M., Hollestelle, A., Benitez, J., Perez, J.I.A., Menéndez, P., Bolla, M.K., Easton, D.F., Schmidt, M.K., Pharoah, P.D., Sherman, M.E., García-Closas, M.
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- 2015
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33. Inclusion of KI67 significantly improves performance of the PREDICT prognostication and prediction model for early breast cancer
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Wishart, Gordon C, Rakha, Emad, Green, Andrew, Ellis, Ian, Ali, Hamid Raza, Provenzano, Elena, Blows, Fiona M, Caldas, Carlos, Pharoah, Paul DP, Ali, Raza [0000-0001-7587-0906], Caldas, Carlos [0000-0003-3547-1489], Pharoah, Paul [0000-0001-8494-732X], and Apollo - University of Cambridge Repository
- Subjects
Adult ,Cancer Research ,Nottingham Breast Cancer Research Centre ,Receptor, ErbB-2 ,Breast Neoplasms ,Middle Aged ,Models, Theoretical ,Prognosis ,Tumor Burden ,Breast cancer ,Ki-67 Antigen ,Oncology ,ROC Curve ,Receptors, Estrogen ,Predictive Value of Tests ,Area Under Curve ,Lymphatic Metastasis ,Genetics ,Humans ,Female ,Prognostic model ,KI67 ,Research Article - Abstract
Background PREDICT (http://www.predict.nhs.uk) is a prognostication and treatment benefit tool for early breast cancer (EBC). The aim of this study was to incorporate the prognostic effect of KI67 status in a new version (v3), and compare performance with the Predict model that includes HER2 status (v2). Methods The validation study was based on 1,726 patients with EBC treated in Nottingham between 1989 and 1998. KI67 positivity for PREDICT is defined as >10% of tumour cells staining positive. ROC curves were constructed for Predict models with (v3) and without (v2) KI67 input. Comparison was made using the method of DeLong. Results In 1274 ER+ patients the predicted number of events at 10 years increased from 196 for v2 to 204 for v3 compared to 221 observed. The area under the ROC curve (AUC) improved from 0.7611 to 0.7676 (p = 0.005) in ER+ patients and from 0.7546 to 0.7595 (p = 0.0008) in all 1726 patients (ER+ and ER-). Conclusion Addition of KI67 to PREDICT has led to a statistically significant improvement in the model performance for ER+ patients and will aid clinical decision making in these patients. Further studies should determine whether other markers including gene expression profiling provide additional prognostic information to that provided by PREDICT.
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- 2014
34. Combined genetic and splicing analysis of BRCA1 c.[594-2A > C; 641A > G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms
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de la Hoya, Miguel, Soukarieh, Omar, Lopez-Perolio, Irene, Vega, Ana, Walker, Logan C., van Ierland, Yvette, Baralle, Diana, Santamarina, Marta, Lattimore, Vanessa, Wijnen, Juul, Whiley, Philip, Blanco, Ana, Raponi, Michela, Hauke, Jan, Wappenschmidt, Barbara, Becker, Alexandra, Hansen, Thomas V. O., Behar, Raquel, Niederacher, Diether, Arnold, Norbert, Dworniczak, Bernd, Steinemann, Doris, Faust, Ulrike, Rubinstein, Wendy, Hulick, Peter J., Houdayer, Claude, Caputo, Sandrine M., Castera, Laurent, Pesaran, Tina, Chao, Elizabeth, Brewer, Carole, Southey, Melissa C., van Asperen, Christi J., Singer, Christian F., Sullivan, Jan, Poplawski, Nicola, Peto, Julian, Johnson, Nichola, Burwinkel, Barbara, Surowy, Harald, Bojesen, Stig E., Flyger, Henrik, Lindblom, Annika, Margolin, Sara, Chang-Claude, Jenny, Rudolph, Anja, Radice, Paolo, Galastri, Laura, Olson, Janet E., Hallberg, Emily, Giles, GrahamG., Milne, Roger L., Andrulis, Irene L., Glendon, Gord, Hall, Per, Czene, Kamila, Blows, Fiona, Shah, Mitul, Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, McGuffog, Lesley, Bolla, Manjeet K., Antoniou, Antonis C., Easton, Douglas F., Couch, Fergus J., Tavtigian, Sean, Vreeswijk, Maaike P., Parsons, Michael, Meeks, Huong D., Martins, Alexandra, Goldgar, David E., Spurdle, Amanda B., de la Hoya, Miguel, Soukarieh, Omar, Lopez-Perolio, Irene, Vega, Ana, Walker, Logan C., van Ierland, Yvette, Baralle, Diana, Santamarina, Marta, Lattimore, Vanessa, Wijnen, Juul, Whiley, Philip, Blanco, Ana, Raponi, Michela, Hauke, Jan, Wappenschmidt, Barbara, Becker, Alexandra, Hansen, Thomas V. O., Behar, Raquel, Niederacher, Diether, Arnold, Norbert, Dworniczak, Bernd, Steinemann, Doris, Faust, Ulrike, Rubinstein, Wendy, Hulick, Peter J., Houdayer, Claude, Caputo, Sandrine M., Castera, Laurent, Pesaran, Tina, Chao, Elizabeth, Brewer, Carole, Southey, Melissa C., van Asperen, Christi J., Singer, Christian F., Sullivan, Jan, Poplawski, Nicola, Peto, Julian, Johnson, Nichola, Burwinkel, Barbara, Surowy, Harald, Bojesen, Stig E., Flyger, Henrik, Lindblom, Annika, Margolin, Sara, Chang-Claude, Jenny, Rudolph, Anja, Radice, Paolo, Galastri, Laura, Olson, Janet E., Hallberg, Emily, Giles, GrahamG., Milne, Roger L., Andrulis, Irene L., Glendon, Gord, Hall, Per, Czene, Kamila, Blows, Fiona, Shah, Mitul, Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, McGuffog, Lesley, Bolla, Manjeet K., Antoniou, Antonis C., Easton, Douglas F., Couch, Fergus J., Tavtigian, Sean, Vreeswijk, Maaike P., Parsons, Michael, Meeks, Huong D., Martins, Alexandra, Goldgar, David E., and Spurdle, Amanda B.
- Abstract
We confirm that BRCA1c.[594-2A > C;641A > G] should not be considered a high-risk pathogenic variant. Importantly, results from our detailed mRNA analysis suggest that BRCA-associated cancer risk is likely not markedly increased for individuals who carry a truncating variant in BRCA1 exons 9 or 10, or any other BRCA1 allele that permits 20-30% of tumor suppressor function. More generally, our findings highlight the importance of assessing naturally occurring alternative splicing for clinical evaluation of variants in disease-causing genes.
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- 2016
35. Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms
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de la Hoya, Miguel, Soukarieh, Omar, López-perolio, Irene, Vega, Ana, Walker, Logan C, Van Ierland, Yvette, Baralle, Diana, Santamariña, Marta, Lattimore, Vanessa, Wijnen, Juul, Whiley, Philip, Blanco, Ana, Raponi, Michela, Hauke, Jan, Wappenschmidt, Barbara, Becker, Alexandra, Hansen, Thomas v O, Behar, Raquel, Investigators, Kconfab, Niederacher, Diether, Arnold, Norbert, Dworniczak, Bernd, Steinemann, Doris, Faust, Ulrike, Rubinstein, Wendy, Hulick, Peter J, Houdayer, Claude, Caputo, Sandrine M., Castera, Laurent, Pesaran, Tina, Chao, Elizabeth, Brewer, Carole, Southey, Melissa C, van Asperen, Christi J, Singer, Christian F, Sullivan, Jan, Poplawski, Nicola, Mai, Phuong L, Peto, Julian, Johnson, Nichola, Burwinkel, Barbara, Surowy, Harald M, Bojesen, Stig E., Flyger, Henrik, Lindblom, Annika, Margolin, Sara, Chang-Claude, Jenny, Rudolph, Anja, Radice, Paolo, Galastri, Laura, Olson, Janet E, Hallberg, Emily, Giles, Graham, Milne, Roger L, Andrulis, Irene L, Glendon, Gord, Hall, Per, Czene, Kamila, Blows, Fiona, Shah, Mitul, Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, McGuffog, Lesley, Bolla, Manjeet K, Antoniou, Antonis C, Easton, Douglas F, Couch, Fergus J, Tavtigian, Sean, Vreeswijk, Maaike P, Parsons, Michael, Meeks, Huong D, Martins, Alexandra, Goldgar, David E, Spurdle, Amanda B, de la Hoya, Miguel, Soukarieh, Omar, López-perolio, Irene, Vega, Ana, Walker, Logan C, Van Ierland, Yvette, Baralle, Diana, Santamariña, Marta, Lattimore, Vanessa, Wijnen, Juul, Whiley, Philip, Blanco, Ana, Raponi, Michela, Hauke, Jan, Wappenschmidt, Barbara, Becker, Alexandra, Hansen, Thomas v O, Behar, Raquel, Investigators, Kconfab, Niederacher, Diether, Arnold, Norbert, Dworniczak, Bernd, Steinemann, Doris, Faust, Ulrike, Rubinstein, Wendy, Hulick, Peter J, Houdayer, Claude, Caputo, Sandrine M., Castera, Laurent, Pesaran, Tina, Chao, Elizabeth, Brewer, Carole, Southey, Melissa C, van Asperen, Christi J, Singer, Christian F, Sullivan, Jan, Poplawski, Nicola, Mai, Phuong L, Peto, Julian, Johnson, Nichola, Burwinkel, Barbara, Surowy, Harald M, Bojesen, Stig E., Flyger, Henrik, Lindblom, Annika, Margolin, Sara, Chang-Claude, Jenny, Rudolph, Anja, Radice, Paolo, Galastri, Laura, Olson, Janet E, Hallberg, Emily, Giles, Graham, Milne, Roger L, Andrulis, Irene L, Glendon, Gord, Hall, Per, Czene, Kamila, Blows, Fiona, Shah, Mitul, Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, McGuffog, Lesley, Bolla, Manjeet K, Antoniou, Antonis C, Easton, Douglas F, Couch, Fergus J, Tavtigian, Sean, Vreeswijk, Maaike P, Parsons, Michael, Meeks, Huong D, Martins, Alexandra, Goldgar, David E, and Spurdle, Amanda B
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- 2016
36. Prognostic value of automated KI67 scoring in breast cancer: a centralised evaluation of 8088 patients from 10 study groups
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Abubakar, Mustapha, primary, Orr, Nick, additional, Daley, Frances, additional, Coulson, Penny, additional, Ali, H. Raza, additional, Blows, Fiona, additional, Benitez, Javier, additional, Milne, Roger, additional, Brenner, Herman, additional, Stegmaier, Christa, additional, Mannermaa, Arto, additional, Chang-Claude, Jenny, additional, Rudolph, Anja, additional, Sinn, Peter, additional, Couch, Fergus J., additional, Devilee, Peter, additional, Tollenaar, Rob A. E. M., additional, Seynaeve, Caroline, additional, Figueroa, Jonine, additional, Sherman, Mark E., additional, Lissowska, Jolanta, additional, Hewitt, Stephen, additional, Eccles, Diana, additional, Hooning, Maartje J., additional, Hollestelle, Antoinette, additional, Martens, John W. M., additional, van Deurzen, Carolien H. M., additional, Investigators, kConFab, additional, Bolla, Manjeet K., additional, Wang, Qin, additional, Jones, Michael, additional, Schoemaker, Minouk, additional, Wesseling, Jelle, additional, van Leeuwen, Flora E., additional, Van ‘t Veer, Laura, additional, Easton, Douglas, additional, Swerdlow, Anthony J., additional, Dowsett, Mitch, additional, Pharoah, Paul D., additional, Schmidt, Marjanka K., additional, and Garcia-Closas, Montserrat, additional
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- 2016
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37. High‐throughput automated scoring of Ki67 in breast cancer tissue microarrays from the Breast Cancer Association Consortium
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Abubakar, Mustapha, primary, Howat, William J, additional, Daley, Frances, additional, Zabaglo, Lila, additional, McDuffus, Leigh‐Anne, additional, Blows, Fiona, additional, Coulson, Penny, additional, Raza Ali, H, additional, Benitez, Javier, additional, Milne, Roger, additional, Brenner, Herman, additional, Stegmaier, Christa, additional, Mannermaa, Arto, additional, Chang‐Claude, Jenny, additional, Rudolph, Anja, additional, Sinn, Peter, additional, Couch, Fergus J, additional, Tollenaar, Rob A.E.M., additional, Devilee, Peter, additional, Figueroa, Jonine, additional, Sherman, Mark E, additional, Lissowska, Jolanta, additional, Hewitt, Stephen, additional, Eccles, Diana, additional, Hooning, Maartje J, additional, Hollestelle, Antoinette, additional, WM Martens, John, additional, HM van Deurzen, Carolien, additional, Investigators, kConFab, additional, Bolla, Manjeet K, additional, Wang, Qin, additional, Jones, Michael, additional, Schoemaker, Minouk, additional, Broeks, Annegien, additional, van Leeuwen, Flora E, additional, Van't Veer, Laura, additional, Swerdlow, Anthony J, additional, Orr, Nick, additional, Dowsett, Mitch, additional, Easton, Douglas, additional, Schmidt, Marjanka K, additional, Pharoah, Paul D, additional, and Garcia‐Closas, Montserrat, additional
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- 2016
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38. Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms
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de la Hoya, Miguel, primary, Soukarieh, Omar, additional, López-Perolio, Irene, additional, Vega, Ana, additional, Walker, Logan C., additional, van Ierland, Yvette, additional, Baralle, Diana, additional, Santamariña, Marta, additional, Lattimore, Vanessa, additional, Wijnen, Juul, additional, Whiley, Philip, additional, Blanco, Ana, additional, Raponi, Michela, additional, Hauke, Jan, additional, Wappenschmidt, Barbara, additional, Becker, Alexandra, additional, Hansen, Thomas V. O., additional, Behar, Raquel, additional, Investigators, KConFaB, additional, Niederacher, Diether, additional, Arnold, Norbert, additional, Dworniczak, Bernd, additional, Steinemann, Doris, additional, Faust, Ulrike, additional, Rubinstein, Wendy, additional, Hulick, Peter J., additional, Houdayer, Claude, additional, Caputo, Sandrine M., additional, Castera, Laurent, additional, Pesaran, Tina, additional, Chao, Elizabeth, additional, Brewer, Carole, additional, Southey, Melissa C., additional, van Asperen, Christi J., additional, Singer, Christian F., additional, Sullivan, Jan, additional, Poplawski, Nicola, additional, Mai, Phuong, additional, Peto, Julian, additional, Johnson, Nichola, additional, Burwinkel, Barbara, additional, Surowy, Harald, additional, Bojesen, Stig E., additional, Flyger, Henrik, additional, Lindblom, Annika, additional, Margolin, Sara, additional, Chang-Claude, Jenny, additional, Rudolph, Anja, additional, Radice, Paolo, additional, Galastri, Laura, additional, Olson, Janet E., additional, Hallberg, Emily, additional, Giles, Graham G., additional, Milne, Roger L., additional, Andrulis, Irene L., additional, Glendon, Gord, additional, Hall, Per, additional, Czene, Kamila, additional, Blows, Fiona, additional, Shah, Mitul, additional, Wang, Qin, additional, Dennis, Joe, additional, Michailidou, Kyriaki, additional, McGuffog, Lesley, additional, Bolla, Manjeet K., additional, Antoniou, Antonis C., additional, Easton, Douglas F., additional, Couch, Fergus J., additional, Tavtigian, Sean, additional, Vreeswijk, Maaike P., additional, Parsons, Michael, additional, Meeks, Huong D., additional, Martins, Alexandra, additional, Goldgar, David E., additional, and Spurdle, Amanda B., additional
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- 2016
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39. Decline in Antigenicity of Tumor Markers by Storage Time Using Pathology Sections Cut From Tissue Microarrays
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Blows, Fiona M., primary, Ali, Hamid R., additional, Dawson, Sarah-J., additional, Le Quesne, John, additional, Provenzano, Elena, additional, Caldas, Carlos, additional, and Pharoah, Paul D.P., additional
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- 2016
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40. Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk
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Wei-Yu Lin, Lin, Camp, Nicola J., Ghoussaini, Maya, Beesley, Jonathan, Michailidou, Kyriaki, Hopper, John L., Apicella, Carmel, Southey, Melissa C., Stone, Jennifer, Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Th Rutgers, Emiel J., Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter A., Haeberle, Lothar, Ekici, Arif B., Beckmann, Matthias W., Peto, Julian, Dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Sawyer, Elinor J., Cheng, Timothy, Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Frederik Marmé, Marmé, Surowy, Harald M., Burwinkel, Barbara, Guénel, Pascal, Truong, Thérèse, Menegaux, Florence, Mulot, Claire, Bojesen, Stig E., Nordestgaard, Børge G., Nielsen, Sune F., Flyger, Henrik, Benitez, Javier, Pilar Zamora, M., Perez, Jose Ignacio Arias, Menéndez, Primitiva, González-Neira, Anna, Pita, Guillermo, Rosario Alonso, M., Álvarez, Nuria, Herrero, Daniel, Anton-Culver, Hoda, Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Lichtner, Peter, Schmutzler, Rita K., Müller-Myhsok, Bertram, Brauch, Hiltrud, Brüning, Thomas, Ko, Yon Dschun, Tessier, Daniel C., Vincent, Daniel, Bacot, Francois, Nevanlinna, Heli, Aittomäki, Kristiina, Blomqvist, Carl, Khan, Sofia, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Horio, Akiyo, Bogdanova, Natalia V., Antonenkova, Natalia N., Dörk, Thilo, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli Matti, Hartikainen, Jaana M., Wu, Anna H., Tseng, Chiu Chen, Van Den Berg, David, Stram, Daniel O., Neven, Patrick, Wauters, Els, Wildiers, Hans, Lambrechts, Diether, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Manoukian, Siranoush, Bonanni, Bernardo, Couch, Fergus J., Wang, Xianshu, Vachon, Celine, Purrington, Kristen, Giles, Graham G., Milne, Roger L., Mclean, Catriona, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Marchand, Loic Le, Simard, Jacques, Goldberg, Mark S., Labrèche, France, Dumont, Martine, Teo, Soo Hwang, Yip, Cheng Har, Hassan, Norhashimah, Vithana, Eranga Nishanthie, Kristensen, Vessela, Zheng, Wei, Deming-Halverson, Sandra, Shrubsole, Martha J., Long, Jirong, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Kauppila, Saila, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Devilee, Peter, Tollenaar, Robert A E M, Seynaeve, Caroline, Van Asperen, Christi J., García-Closas, Montserrat, Figueroa, Jonine, Lissowska, Jolanta, Brinton, Louise, Czene, Kamila, Darabi, Hatef, Eriksson, Mikael, Brand, Judith S., Hooning, Maartje J., Hollestelle, Antoinette, Van DenOuweland, Ans M W, Jager, Agnes, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Shu, Xiao Ou, Lu, Wei, Gao, Yu Tang, Cai, Hui, Cross, Simon S., Reed, Malcolm W R, Blot, William, Signorello, Lisa B., Cai, Qiuyin, Pharoah, Paul D P, Perkins, Barbara, Shah, Mitul, Blows, Fiona M., Kang, Daehee, Yoo, Keun Young, Noh, Dong Young, Hartman, Mikael, Miao, Hui, Chia, Kee Seng, Putti, Thomas Choudary, Hamann, Ute, Luccarini, Craig, Baynes, Caroline, Ahmed, Shahana, Maranian, Mel, Healey, Catherine S., Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, Mckay, James, Slager, Susan, Toland, Amanda E., Yannoukakos, Drakoulis, Shen, Chen Yang, Hsiung, Chia Ni, Wu, Pei Ei, Ding, Shian Ling, Ashworth, Alan, Jones, Michael, Orr, Nick, Swerdlow, Anthony J., Tsimiklis, Helen, Makalic, Enes, Schmidt, Daniel F., Bui, Quang M., Chanock, Stephen J., Hunter, David J., Hein, Rebecca, Dahmen, Norbert, Beckmann, Lars, Aaltonen, Kirsimari, Muranen, Taru A., Heikkinen, Tuomas, Irwanto, Astrid, Rahman, Nazneen, Turnbull, Clare A., Waisfisz, Quinten, Meijers-Heijboer, Hanne E J, Adank, Muriel A., Van Der Luijt, Rob B., Hall, Per, Chenevix-Trench, Georgia, Dunning, Alison, Easton, Douglas F., Cox, Angela, Wei-Yu Lin, Lin, Camp, Nicola J., Ghoussaini, Maya, Beesley, Jonathan, Michailidou, Kyriaki, Hopper, John L., Apicella, Carmel, Southey, Melissa C., Stone, Jennifer, Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Th Rutgers, Emiel J., Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter A., Haeberle, Lothar, Ekici, Arif B., Beckmann, Matthias W., Peto, Julian, Dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Sawyer, Elinor J., Cheng, Timothy, Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Frederik Marmé, Marmé, Surowy, Harald M., Burwinkel, Barbara, Guénel, Pascal, Truong, Thérèse, Menegaux, Florence, Mulot, Claire, Bojesen, Stig E., Nordestgaard, Børge G., Nielsen, Sune F., Flyger, Henrik, Benitez, Javier, Pilar Zamora, M., Perez, Jose Ignacio Arias, Menéndez, Primitiva, González-Neira, Anna, Pita, Guillermo, Rosario Alonso, M., Álvarez, Nuria, Herrero, Daniel, Anton-Culver, Hoda, Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Lichtner, Peter, Schmutzler, Rita K., Müller-Myhsok, Bertram, Brauch, Hiltrud, Brüning, Thomas, Ko, Yon Dschun, Tessier, Daniel C., Vincent, Daniel, Bacot, Francois, Nevanlinna, Heli, Aittomäki, Kristiina, Blomqvist, Carl, Khan, Sofia, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Horio, Akiyo, Bogdanova, Natalia V., Antonenkova, Natalia N., Dörk, Thilo, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli Matti, Hartikainen, Jaana M., Wu, Anna H., Tseng, Chiu Chen, Van Den Berg, David, Stram, Daniel O., Neven, Patrick, Wauters, Els, Wildiers, Hans, Lambrechts, Diether, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Manoukian, Siranoush, Bonanni, Bernardo, Couch, Fergus J., Wang, Xianshu, Vachon, Celine, Purrington, Kristen, Giles, Graham G., Milne, Roger L., Mclean, Catriona, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Marchand, Loic Le, Simard, Jacques, Goldberg, Mark S., Labrèche, France, Dumont, Martine, Teo, Soo Hwang, Yip, Cheng Har, Hassan, Norhashimah, Vithana, Eranga Nishanthie, Kristensen, Vessela, Zheng, Wei, Deming-Halverson, Sandra, Shrubsole, Martha J., Long, Jirong, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Kauppila, Saila, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Devilee, Peter, Tollenaar, Robert A E M, Seynaeve, Caroline, Van Asperen, Christi J., García-Closas, Montserrat, Figueroa, Jonine, Lissowska, Jolanta, Brinton, Louise, Czene, Kamila, Darabi, Hatef, Eriksson, Mikael, Brand, Judith S., Hooning, Maartje J., Hollestelle, Antoinette, Van DenOuweland, Ans M W, Jager, Agnes, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Shu, Xiao Ou, Lu, Wei, Gao, Yu Tang, Cai, Hui, Cross, Simon S., Reed, Malcolm W R, Blot, William, Signorello, Lisa B., Cai, Qiuyin, Pharoah, Paul D P, Perkins, Barbara, Shah, Mitul, Blows, Fiona M., Kang, Daehee, Yoo, Keun Young, Noh, Dong Young, Hartman, Mikael, Miao, Hui, Chia, Kee Seng, Putti, Thomas Choudary, Hamann, Ute, Luccarini, Craig, Baynes, Caroline, Ahmed, Shahana, Maranian, Mel, Healey, Catherine S., Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, Mckay, James, Slager, Susan, Toland, Amanda E., Yannoukakos, Drakoulis, Shen, Chen Yang, Hsiung, Chia Ni, Wu, Pei Ei, Ding, Shian Ling, Ashworth, Alan, Jones, Michael, Orr, Nick, Swerdlow, Anthony J., Tsimiklis, Helen, Makalic, Enes, Schmidt, Daniel F., Bui, Quang M., Chanock, Stephen J., Hunter, David J., Hein, Rebecca, Dahmen, Norbert, Beckmann, Lars, Aaltonen, Kirsimari, Muranen, Taru A., Heikkinen, Tuomas, Irwanto, Astrid, Rahman, Nazneen, Turnbull, Clare A., Waisfisz, Quinten, Meijers-Heijboer, Hanne E J, Adank, Muriel A., Van Der Luijt, Rob B., Hall, Per, Chenevix-Trench, Georgia, Dunning, Alison, Easton, Douglas F., and Cox, Angela
- Published
- 2015
41. Annexin A1 expression in a pooled breast cancer series
- Author
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University of Helsinki, Department of Obstetrics and Gynecology, University of Helsinki, Haartman Institute (-2009), University of Helsinki, Department of Pathology, University of Helsinki, Medicum, University of Helsinki, Clinicum, Sobral-Leite, Marcelo, Wesseling, Jelle, Smit, Vincent T. H. B. M., Nevanlinna, Heli, van Miltenburg, Martine H., Sanders, Joyce, Hofland, Ingrid, Blows, Fiona M., Coulson, Penny, Patrycja, Gazinska, Schellens, Jan H. M., Fagerholm, Rainer, Heikkila, Paivi, Aittomaki, Kristiina, Blomqvist, Carl, Provenzano, Elena, Ali, Hamid Raza, Figueroa, Jonine, Sherman, Mark, Lissowska, Jolanta, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Phillips, Kelly-Anne, Couch, Fergus J., Olson, Janet E., Vachon, Celine, Visscher, Daniel, Brenner, Hermann, Butterbach, Katja, Arndt, Volker, Holleczek, Bernd, Hooning, Maartje J., Hollestelle, Antoinette, Martens, John W. M., van Deurzen, Carolien H. M., van de Water, Bob, Broeks, Annegien, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Easton, Douglas F., Pharoah, Paul D. P., Garcia-Closas, Montserrat, de Graauw, Marjo, Schmidt, Marjanka K., kConFab AOCS Investigators, University of Helsinki, Department of Obstetrics and Gynecology, University of Helsinki, Haartman Institute (-2009), University of Helsinki, Department of Pathology, University of Helsinki, Medicum, University of Helsinki, Clinicum, Sobral-Leite, Marcelo, Wesseling, Jelle, Smit, Vincent T. H. B. M., Nevanlinna, Heli, van Miltenburg, Martine H., Sanders, Joyce, Hofland, Ingrid, Blows, Fiona M., Coulson, Penny, Patrycja, Gazinska, Schellens, Jan H. M., Fagerholm, Rainer, Heikkila, Paivi, Aittomaki, Kristiina, Blomqvist, Carl, Provenzano, Elena, Ali, Hamid Raza, Figueroa, Jonine, Sherman, Mark, Lissowska, Jolanta, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Phillips, Kelly-Anne, Couch, Fergus J., Olson, Janet E., Vachon, Celine, Visscher, Daniel, Brenner, Hermann, Butterbach, Katja, Arndt, Volker, Holleczek, Bernd, Hooning, Maartje J., Hollestelle, Antoinette, Martens, John W. M., van Deurzen, Carolien H. M., van de Water, Bob, Broeks, Annegien, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Easton, Douglas F., Pharoah, Paul D. P., Garcia-Closas, Montserrat, de Graauw, Marjo, Schmidt, Marjanka K., and kConFab AOCS Investigators
- Abstract
Background: Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors. However, little is known about the prognostic value of ANXA1 in breast cancer. The purpose of this study is to evaluate the association between ANXA1 expression, BRCA1/2 germline carriership, specific tumor subtypes and survival in breast cancer patients. Methods: Clinical-pathological information and follow-up data were collected from nine breast cancer studies from the Breast Cancer Association Consortium (BCAC) (n = 5,752) and from one study of familial breast cancer patients with BRCA1/2 mutations (n = 107). ANXA1 expression was scored based on the percentage of immunohistochemical staining in tumor cells. Survival analyses were performed using a multivariable Cox model. Results: The frequency of ANXA1 positive tumors was higher in familial breast cancer patients with BRCA1/2 mutations than in BCAC patients, with 48.6 % versus 12.4 %, respectively; P <0.0001. ANXA1 was also highly expressed in BCAC tumors that were poorly differentiated, triple negative, EGFR-CK5/6 positive or had developed in patients at a young age. In the first 5 years of follow-up, patients with ANXA1 positive tumors had a worse breast cancer-specific survival (BCSS) than ANXA1 negative (HRadj = 1.35; 95 % CI = 1.05-1.73), but the association weakened after 10 years (HRadj = 1.13; 95 % CI = 0.91-1.40). ANXA1 was a significant independent predictor of survival in HER2+ patients (10-years BCSS: HRadj = 1.70; 95 % CI = 1.17-2.45). Conclusions: ANXA1 is overexpressed in familial breast cancer patients with BRCA1/2 mutations and correlated with poor prognosis features: triple negative and poorly differentiated tumors. ANXA1 might be a biomarker candidate for breast cancer survival prediction in high risk groups such as HER2+ cases.
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- 2015
42. Annexin A1 expression in a pooled breast cancer series: Association with tumor subtypes and prognosis
- Author
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Pharmacoepidemiology and Clinical Pharmacology, Sub Clinical Pharmacology, Sobral-Leite, Marcelo, Wesseling, Jelle, Smit, Vincent T H B M, Nevanlinna, Heli, van Miltenburg, Martine H., Sanders, Joyce, Hofland, Ingrid, Blows, Fiona M., Coulson, Penny, Patrycja, Gazinska, Schellens, Jan H M, Fagerholm, Rainer, Heikkilä, Päivi, Aittomäki, Kristiina, Blomqvist, Carl, Provenzano, Elena, Ali, Hamid Raza, Figueroa, Jonine, Sherman, Mark, Lissowska, Jolanta, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli Matti, Hartikainen, Jaana M., Phillips, Kelly Anne, Couch, Fergus J., Olson, Janet E., Vachon, Celine, Visscher, Daniel, Brenner, Hermann, Butterbach, Katja, Arndt, Volker, Holleczek, Bernd, Hooning, Maartje J., Hollestelle, Antoinette, Martens, John W M, van Deurzen, Carolien H M, van de Water, Bob, Broeks, Annegien, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Easton, Douglas F., Pharoah, Paul D P, García-Closas, Montserrat, de Graauw, Marjo, Schmidt, Marjanka K., Aghmesheh, Morteza, Amor, David, Andrews, Lesley, Antill, Yoland, Armitage, Shane, Arnold, Leanne, Balleine, Rosemary, Bankier, Agnes, Bastick, Patti, Beesley, Jonathan, Beilby, John, Bennett, Barbara, Bennett, Ian, Berry, Geoffrey, Blackburn, Anneke, Bogwitz, Michael, Brennan, Meagan, Brown, Melissa, Buckley, Michael, Burgess, Matthew, Burke, Jo, Butow, Phyllis, Byron, Keith, Callen, David, Campbell, Ian, Chauhan, Deepa, Chauhan, Manisha, Christian, Alice, Clarke, Christine, Colley, Alison, Cotton, Dick, Crook, Ashley, Cui, James, Culling, Bronwyn, Cummings, Margaret, Dawson, Sarah Jane, deFazio, Anna, Delatycki, Martin, Dickson, Rebecca, Dixon, Joanne, Dobrovic, Alexander, Dudding, Tracy, Edkins, Ted, Edwards, Stacey, Eisenbruch, Maurice, Farshid, Gelareh, Fawcett, Susan, Fellows, Andrew, Fenton, Georgina, Field, Michael, Firgaira, Frank, Flanagan, James, Fleming, Jean, Fong, Peter, Forbes, John, Fox, Stephen, French, Juliet, Friedlander, Michael, Gaff, Clara, Gardner, Mac, Gattas, Mike, George, Peter, Giles, Graham, Gill, Grantley, Goldblatt, Jack, Greening, Sian, Grist, Scott, Haan, Eric, Hardie, Kate, Harris, Marion, Hart, Stewart, Hayward, Nick, Healey, Sue, Heiniger, Louise, Hopper, John, Humphrey, Evelyn, Hunt, Clare, James, Paul, Jenkins, Mark, Jones, Alison, Kefford, Rick, Kidd, Alexa, Kiely, Belinda, Kirk, Judy, Koehler, Jessica, Kollias, James, Kovalenko, Serguei, Lakhani, Sunil, Leaming, Amanda, Leary, Jennifer, Lim, Jacqueline, Lindeman, Geoff, Lipton, Lara, Lobb, Liz, Mann, Graham, Marsh, Deborah, McLachlan, Sue Anne, Meiser, Bettina, Meldrum, Cliff, Milne, Roger, Mitchell, Gillian, Newman, Beth, Niedermayr, Eveline, Nightingale, Sophie, O'Connell, Shona, O'Loughlin, Imelda, Osborne, Richard, Pachter, Nick, Patterson, Briony, Peters, Lester, Phillips, Kelly, Price, Melanie, Purser, Lynne, Reeve, Tony, Reeve, Jeanne, Richards, Robert, Rickard, Edwina, Robinson, Bridget, Rudzki, Barney, Saleh, Mona, Salisbury, Elizabeth, Sambrook, Joe, Saunders, Christobel, Saunus, Jodi, Sayer, Robyn, Scott, Elizabeth, Scott, Rodney, Scott, Clare, Seshadri, Ram, Sexton, Adrienne, Sharma, Raghwa, Shelling, Andrew, Simpson, Peter, Southey, Melissa, Spurdle, Amanda, Suthers, Graeme, Sykes, Pamela, Tassell, Margaret, Taylor, Donna, Taylor, Jessica, Thierry, Benjamin, Thomas, Susan, Thompson, Ella, Thorne, Heather, Townshend, Sharron, Trainer, Alison, Tran, Lan, Tucker, Kathy, Tyler, Janet, Visvader, Jane, Walker, Logan, Walpole, Ian, Ward, Robin, Waring, Paul, Warner, Bev, Warren, Graham, Williams, Rachael, Wilson, Judy, Winship, Ingrid, Wu, Kathy, Young, Mary Ann, Bowtell, D., Green, A., Webb, P., de Fazio, A., Gertig, D., Pharmacoepidemiology and Clinical Pharmacology, Sub Clinical Pharmacology, Sobral-Leite, Marcelo, Wesseling, Jelle, Smit, Vincent T H B M, Nevanlinna, Heli, van Miltenburg, Martine H., Sanders, Joyce, Hofland, Ingrid, Blows, Fiona M., Coulson, Penny, Patrycja, Gazinska, Schellens, Jan H M, Fagerholm, Rainer, Heikkilä, Päivi, Aittomäki, Kristiina, Blomqvist, Carl, Provenzano, Elena, Ali, Hamid Raza, Figueroa, Jonine, Sherman, Mark, Lissowska, Jolanta, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli Matti, Hartikainen, Jaana M., Phillips, Kelly Anne, Couch, Fergus J., Olson, Janet E., Vachon, Celine, Visscher, Daniel, Brenner, Hermann, Butterbach, Katja, Arndt, Volker, Holleczek, Bernd, Hooning, Maartje J., Hollestelle, Antoinette, Martens, John W M, van Deurzen, Carolien H M, van de Water, Bob, Broeks, Annegien, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Easton, Douglas F., Pharoah, Paul D P, García-Closas, Montserrat, de Graauw, Marjo, Schmidt, Marjanka K., Aghmesheh, Morteza, Amor, David, Andrews, Lesley, Antill, Yoland, Armitage, Shane, Arnold, Leanne, Balleine, Rosemary, Bankier, Agnes, Bastick, Patti, Beesley, Jonathan, Beilby, John, Bennett, Barbara, Bennett, Ian, Berry, Geoffrey, Blackburn, Anneke, Bogwitz, Michael, Brennan, Meagan, Brown, Melissa, Buckley, Michael, Burgess, Matthew, Burke, Jo, Butow, Phyllis, Byron, Keith, Callen, David, Campbell, Ian, Chauhan, Deepa, Chauhan, Manisha, Christian, Alice, Clarke, Christine, Colley, Alison, Cotton, Dick, Crook, Ashley, Cui, James, Culling, Bronwyn, Cummings, Margaret, Dawson, Sarah Jane, deFazio, Anna, Delatycki, Martin, Dickson, Rebecca, Dixon, Joanne, Dobrovic, Alexander, Dudding, Tracy, Edkins, Ted, Edwards, Stacey, Eisenbruch, Maurice, Farshid, Gelareh, Fawcett, Susan, Fellows, Andrew, Fenton, Georgina, Field, Michael, Firgaira, Frank, Flanagan, James, Fleming, Jean, Fong, Peter, Forbes, John, Fox, Stephen, French, Juliet, Friedlander, Michael, Gaff, Clara, Gardner, Mac, Gattas, Mike, George, Peter, Giles, Graham, Gill, Grantley, Goldblatt, Jack, Greening, Sian, Grist, Scott, Haan, Eric, Hardie, Kate, Harris, Marion, Hart, Stewart, Hayward, Nick, Healey, Sue, Heiniger, Louise, Hopper, John, Humphrey, Evelyn, Hunt, Clare, James, Paul, Jenkins, Mark, Jones, Alison, Kefford, Rick, Kidd, Alexa, Kiely, Belinda, Kirk, Judy, Koehler, Jessica, Kollias, James, Kovalenko, Serguei, Lakhani, Sunil, Leaming, Amanda, Leary, Jennifer, Lim, Jacqueline, Lindeman, Geoff, Lipton, Lara, Lobb, Liz, Mann, Graham, Marsh, Deborah, McLachlan, Sue Anne, Meiser, Bettina, Meldrum, Cliff, Milne, Roger, Mitchell, Gillian, Newman, Beth, Niedermayr, Eveline, Nightingale, Sophie, O'Connell, Shona, O'Loughlin, Imelda, Osborne, Richard, Pachter, Nick, Patterson, Briony, Peters, Lester, Phillips, Kelly, Price, Melanie, Purser, Lynne, Reeve, Tony, Reeve, Jeanne, Richards, Robert, Rickard, Edwina, Robinson, Bridget, Rudzki, Barney, Saleh, Mona, Salisbury, Elizabeth, Sambrook, Joe, Saunders, Christobel, Saunus, Jodi, Sayer, Robyn, Scott, Elizabeth, Scott, Rodney, Scott, Clare, Seshadri, Ram, Sexton, Adrienne, Sharma, Raghwa, Shelling, Andrew, Simpson, Peter, Southey, Melissa, Spurdle, Amanda, Suthers, Graeme, Sykes, Pamela, Tassell, Margaret, Taylor, Donna, Taylor, Jessica, Thierry, Benjamin, Thomas, Susan, Thompson, Ella, Thorne, Heather, Townshend, Sharron, Trainer, Alison, Tran, Lan, Tucker, Kathy, Tyler, Janet, Visvader, Jane, Walker, Logan, Walpole, Ian, Ward, Robin, Waring, Paul, Warner, Bev, Warren, Graham, Williams, Rachael, Wilson, Judy, Winship, Ingrid, Wu, Kathy, Young, Mary Ann, Bowtell, D., Green, A., Webb, P., de Fazio, A., and Gertig, D.
- Published
- 2015
43. Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk
- Author
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Genetica Sectie Genoomdiagnostiek, Cancer, Wei-Yu Lin, Lin, Camp, Nicola J., Ghoussaini, Maya, Beesley, Jonathan, Michailidou, Kyriaki, Hopper, John L., Apicella, Carmel, Southey, Melissa C., Stone, Jennifer, Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Th Rutgers, Emiel J., Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter A., Haeberle, Lothar, Ekici, Arif B., Beckmann, Matthias W., Peto, Julian, Dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Sawyer, Elinor J., Cheng, Timothy, Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Frederik Marmé, Marmé, Surowy, Harald M., Burwinkel, Barbara, Guénel, Pascal, Truong, Thérèse, Menegaux, Florence, Mulot, Claire, Bojesen, Stig E., Nordestgaard, Børge G., Nielsen, Sune F., Flyger, Henrik, Benitez, Javier, Pilar Zamora, M., Perez, Jose Ignacio Arias, Menéndez, Primitiva, González-Neira, Anna, Pita, Guillermo, Rosario Alonso, M., Álvarez, Nuria, Herrero, Daniel, Anton-Culver, Hoda, Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Lichtner, Peter, Schmutzler, Rita K., Müller-Myhsok, Bertram, Brauch, Hiltrud, Brüning, Thomas, Ko, Yon Dschun, Tessier, Daniel C., Vincent, Daniel, Bacot, Francois, Nevanlinna, Heli, Aittomäki, Kristiina, Blomqvist, Carl, Khan, Sofia, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Horio, Akiyo, Bogdanova, Natalia V., Antonenkova, Natalia N., Dörk, Thilo, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli Matti, Hartikainen, Jaana M., Wu, Anna H., Tseng, Chiu Chen, Van Den Berg, David, Stram, Daniel O., Neven, Patrick, Wauters, Els, Wildiers, Hans, Lambrechts, Diether, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Manoukian, Siranoush, Bonanni, Bernardo, Couch, Fergus J., Wang, Xianshu, Vachon, Celine, Purrington, Kristen, Giles, Graham G., Milne, Roger L., Mclean, Catriona, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Marchand, Loic Le, Simard, Jacques, Goldberg, Mark S., Labrèche, France, Dumont, Martine, Teo, Soo Hwang, Yip, Cheng Har, Hassan, Norhashimah, Vithana, Eranga Nishanthie, Kristensen, Vessela, Zheng, Wei, Deming-Halverson, Sandra, Shrubsole, Martha J., Long, Jirong, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Kauppila, Saila, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Devilee, Peter, Tollenaar, Robert A E M, Seynaeve, Caroline, Van Asperen, Christi J., García-Closas, Montserrat, Figueroa, Jonine, Lissowska, Jolanta, Brinton, Louise, Czene, Kamila, Darabi, Hatef, Eriksson, Mikael, Brand, Judith S., Hooning, Maartje J., Hollestelle, Antoinette, Van DenOuweland, Ans M W, Jager, Agnes, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Shu, Xiao Ou, Lu, Wei, Gao, Yu Tang, Cai, Hui, Cross, Simon S., Reed, Malcolm W R, Blot, William, Signorello, Lisa B., Cai, Qiuyin, Pharoah, Paul D P, Perkins, Barbara, Shah, Mitul, Blows, Fiona M., Kang, Daehee, Yoo, Keun Young, Noh, Dong Young, Hartman, Mikael, Miao, Hui, Chia, Kee Seng, Putti, Thomas Choudary, Hamann, Ute, Luccarini, Craig, Baynes, Caroline, Ahmed, Shahana, Maranian, Mel, Healey, Catherine S., Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, Mckay, James, Slager, Susan, Toland, Amanda E., Yannoukakos, Drakoulis, Shen, Chen Yang, Hsiung, Chia Ni, Wu, Pei Ei, Ding, Shian Ling, Ashworth, Alan, Jones, Michael, Orr, Nick, Swerdlow, Anthony J., Tsimiklis, Helen, Makalic, Enes, Schmidt, Daniel F., Bui, Quang M., Chanock, Stephen J., Hunter, David J., Hein, Rebecca, Dahmen, Norbert, Beckmann, Lars, Aaltonen, Kirsimari, Muranen, Taru A., Heikkinen, Tuomas, Irwanto, Astrid, Rahman, Nazneen, Turnbull, Clare A., Waisfisz, Quinten, Meijers-Heijboer, Hanne E J, Adank, Muriel A., Van Der Luijt, Rob B., Hall, Per, Chenevix-Trench, Georgia, Dunning, Alison, Easton, Douglas F., Cox, Angela, Genetica Sectie Genoomdiagnostiek, Cancer, Wei-Yu Lin, Lin, Camp, Nicola J., Ghoussaini, Maya, Beesley, Jonathan, Michailidou, Kyriaki, Hopper, John L., Apicella, Carmel, Southey, Melissa C., Stone, Jennifer, Schmidt, Marjanka K., Broeks, Annegien, Van't Veer, Laura J., Th Rutgers, Emiel J., Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter A., Haeberle, Lothar, Ekici, Arif B., Beckmann, Matthias W., Peto, Julian, Dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Sawyer, Elinor J., Cheng, Timothy, Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Frederik Marmé, Marmé, Surowy, Harald M., Burwinkel, Barbara, Guénel, Pascal, Truong, Thérèse, Menegaux, Florence, Mulot, Claire, Bojesen, Stig E., Nordestgaard, Børge G., Nielsen, Sune F., Flyger, Henrik, Benitez, Javier, Pilar Zamora, M., Perez, Jose Ignacio Arias, Menéndez, Primitiva, González-Neira, Anna, Pita, Guillermo, Rosario Alonso, M., Álvarez, Nuria, Herrero, Daniel, Anton-Culver, Hoda, Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Lichtner, Peter, Schmutzler, Rita K., Müller-Myhsok, Bertram, Brauch, Hiltrud, Brüning, Thomas, Ko, Yon Dschun, Tessier, Daniel C., Vincent, Daniel, Bacot, Francois, Nevanlinna, Heli, Aittomäki, Kristiina, Blomqvist, Carl, Khan, Sofia, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Horio, Akiyo, Bogdanova, Natalia V., Antonenkova, Natalia N., Dörk, Thilo, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli Matti, Hartikainen, Jaana M., Wu, Anna H., Tseng, Chiu Chen, Van Den Berg, David, Stram, Daniel O., Neven, Patrick, Wauters, Els, Wildiers, Hans, Lambrechts, Diether, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Manoukian, Siranoush, Bonanni, Bernardo, Couch, Fergus J., Wang, Xianshu, Vachon, Celine, Purrington, Kristen, Giles, Graham G., Milne, Roger L., Mclean, Catriona, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Marchand, Loic Le, Simard, Jacques, Goldberg, Mark S., Labrèche, France, Dumont, Martine, Teo, Soo Hwang, Yip, Cheng Har, Hassan, Norhashimah, Vithana, Eranga Nishanthie, Kristensen, Vessela, Zheng, Wei, Deming-Halverson, Sandra, Shrubsole, Martha J., Long, Jirong, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Kauppila, Saila, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Devilee, Peter, Tollenaar, Robert A E M, Seynaeve, Caroline, Van Asperen, Christi J., García-Closas, Montserrat, Figueroa, Jonine, Lissowska, Jolanta, Brinton, Louise, Czene, Kamila, Darabi, Hatef, Eriksson, Mikael, Brand, Judith S., Hooning, Maartje J., Hollestelle, Antoinette, Van DenOuweland, Ans M W, Jager, Agnes, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Shu, Xiao Ou, Lu, Wei, Gao, Yu Tang, Cai, Hui, Cross, Simon S., Reed, Malcolm W R, Blot, William, Signorello, Lisa B., Cai, Qiuyin, Pharoah, Paul D P, Perkins, Barbara, Shah, Mitul, Blows, Fiona M., Kang, Daehee, Yoo, Keun Young, Noh, Dong Young, Hartman, Mikael, Miao, Hui, Chia, Kee Seng, Putti, Thomas Choudary, Hamann, Ute, Luccarini, Craig, Baynes, Caroline, Ahmed, Shahana, Maranian, Mel, Healey, Catherine S., Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, Mckay, James, Slager, Susan, Toland, Amanda E., Yannoukakos, Drakoulis, Shen, Chen Yang, Hsiung, Chia Ni, Wu, Pei Ei, Ding, Shian Ling, Ashworth, Alan, Jones, Michael, Orr, Nick, Swerdlow, Anthony J., Tsimiklis, Helen, Makalic, Enes, Schmidt, Daniel F., Bui, Quang M., Chanock, Stephen J., Hunter, David J., Hein, Rebecca, Dahmen, Norbert, Beckmann, Lars, Aaltonen, Kirsimari, Muranen, Taru A., Heikkinen, Tuomas, Irwanto, Astrid, Rahman, Nazneen, Turnbull, Clare A., Waisfisz, Quinten, Meijers-Heijboer, Hanne E J, Adank, Muriel A., Van Der Luijt, Rob B., Hall, Per, Chenevix-Trench, Georgia, Dunning, Alison, Easton, Douglas F., and Cox, Angela
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- 2015
44. Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium
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Howat, William J, Blows, Fiona M, Provenzano, Elena, Brook, Mark N, Morris, Lorna, Gazinska, Patrycja, Johnson, Nicola, McDuffus, Leigh-Anne, Miller, Jodi, Sawyer, Elinor J, Pinder, Sarah, van Deurzen, Carolien H M, Jones, Louise, Sironen, Reijo, Visscher, Daniel, Caldas, Carlos, Daley, Frances, Coulson, Penny, Broeks, Annegien, Sanders, Joyce, Wesseling, Jelle, Nevanlinna, Heli, Fagerholm, Rainer, Blomqvist, Carl, Heikkilä, Päivi, Ali, H Raza, Dawson, Sarah-Jane, Figueroa, Jonine, Lissowska, Jolanta, Brinton, Louise, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Cox, Angela, Brock, Ian W, Cross, Simon S, Reed, Malcolm W, Couch, Fergus J, Olson, Janet E, Devillee, Peter, Mesker, Wilma E, Seyaneve, Caroline M, Hollestelle, Antoinette, Benitez, Javier, Perez, Jose Ignacio Arias, Menéndez, Primitiva, Bolla, Manjeet K, Easton, Douglas F, Schmidt, Marjanka K, Pharoah, Paul D, Sherman, Mark E, García-Closas, Montserrat, Howat, William J, Blows, Fiona M, Provenzano, Elena, Brook, Mark N, Morris, Lorna, Gazinska, Patrycja, Johnson, Nicola, McDuffus, Leigh-Anne, Miller, Jodi, Sawyer, Elinor J, Pinder, Sarah, van Deurzen, Carolien H M, Jones, Louise, Sironen, Reijo, Visscher, Daniel, Caldas, Carlos, Daley, Frances, Coulson, Penny, Broeks, Annegien, Sanders, Joyce, Wesseling, Jelle, Nevanlinna, Heli, Fagerholm, Rainer, Blomqvist, Carl, Heikkilä, Päivi, Ali, H Raza, Dawson, Sarah-Jane, Figueroa, Jonine, Lissowska, Jolanta, Brinton, Louise, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Cox, Angela, Brock, Ian W, Cross, Simon S, Reed, Malcolm W, Couch, Fergus J, Olson, Janet E, Devillee, Peter, Mesker, Wilma E, Seyaneve, Caroline M, Hollestelle, Antoinette, Benitez, Javier, Perez, Jose Ignacio Arias, Menéndez, Primitiva, Bolla, Manjeet K, Easton, Douglas F, Schmidt, Marjanka K, Pharoah, Paul D, Sherman, Mark E, and García-Closas, Montserrat
- Abstract
Breast cancer risk factors and clinical outcomes vary by tumour marker expression. However, individual studies often lack the power required to assess these relationships, and large-scale analyses are limited by the need for high throughput, standardized scoring methods. To address these limitations, we assessed whether automated image analysis of immunohistochemically stained tissue microarrays can permit rapid, standardized scoring of tumour markers from multiple studies. Tissue microarray sections prepared in nine studies containing 20 263 cores from 8267 breast cancers stained for two nuclear (oestrogen receptor, progesterone receptor), two membranous (human epidermal growth factor receptor 2 and epidermal growth factor receptor) and one cytoplasmic (cytokeratin 5/6) marker were scanned as digital images. Automated algorithms were used to score markers in tumour cells using the Ariol system. We compared automated scores against visual reads, and their associations with breast cancer survival. Approximately 65-70% of tissue microarray cores were satisfactory for scoring. Among satisfactory cores, agreement between dichotomous automated and visual scores was highest for oestrogen receptor (Kappa = 0.76), followed by human epidermal growth factor receptor 2 (Kappa = 0.69) and progesterone receptor (Kappa = 0.67). Automated quantitative scores for these markers were associated with hazard ratios for breast cancer mortality in a dose-response manner. Considering visual scores of epidermal growth factor receptor or cytokeratin 5/6 as the reference, automated scoring achieved excellent negative predictive value (96-98%), but yielded many false positives (positive predictive value = 30-32%). For all markers, we observed substantial heterogeneity in automated scoring performance across tissue microarrays. Automated analysis is a potentially useful tool for large-scale, quantitative scoring of immunohistochemically stained tissue microarrays available in consortia. How
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- 2015
45. Heterogeneity of luminal breast cancer characterised by immunohistochemical expression of basal markers
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Sung, Hyuna, primary, Garcia-Closas, Montserrat, additional, Chang-Claude, Jenny, additional, Blows, Fiona M, additional, Ali, H Raza, additional, Figueroa, Jonine, additional, Nevanlinna, Heli, additional, Fagerholm, Rainer, additional, Heikkilä, Päivi, additional, Blomqvist, Carl, additional, Giles, Graham G, additional, Milne, Roger L, additional, Southey, Melissa C, additional, McLean, Catriona, additional, Mannermaa, Arto, additional, Kosma, Veli-Matti, additional, Kataja, Vesa, additional, Sironen, Reijo, additional, Couch, Fergus J, additional, Olson, Janet E, additional, Hallberg, Emily, additional, Olswold, Curtis, additional, Cox, Angela, additional, Cross, Simon S, additional, Kraft, Peter, additional, Tamimi, Rulla M, additional, Eliassen, A Heather, additional, Schmidt, Marjanka K, additional, Bolla, Manjeet K, additional, Wang, Qin, additional, Easton, Douglas, additional, Howat, William J, additional, Coulson, Penny, additional, Pharoah, Paul DP, additional, Sherman, Mark E, additional, and Yang, Xiaohong R, additional
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- 2015
- Full Text
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46. Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer
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Stevens, Kristen N. Vachon, Celine M. Lee, Adam M. Slager, Susan Lesnick, Timothy Olswold, Curtis Fasching, Peter A. and Miron, Penelope Eccles, Diana Carpenter, Jane E. Godwin, Andrew K. Ambrosone, Christine Winqvist, Robert Brauch, Hiltrud Schmidt, Marjanka K. Cox, Angela Cross, Simon S. and Sawyer, Elinor Hartmann, Arndt Beckmann, Matthias W. and Schulz-Wendtland, Ruediger Ekici, Arif B. Tapper, William J. and Gerty, Susan M. Durcan, Lorraine Graham, Nikki Hein, Rebecca and Nickels, Stephan Flesch-Janys, Dieter Heinz, Judith and Sinn, Hans-Peter Konstantopoulou, Irene Fostira, Florentia and Pectasides, Dimitrios Dimopoulos, Athanasios M. Fountzilas, George Clarke, Christine L. Balleine, Rosemary Olson, Janet E. Fredericksen, Zachary Diasio, Robert B. Pathak, Harsh and Ross, Eric Weaver, JoEllen Ruediger, Thomas Forsti, Asta and Duennebier, Thomas Ademuyiwa, Foluso Kulkarni, Swati and Pylkaes, Katri Jukkola-Vuorinen, Arja Ko, Yon-Dschun Van Limbergen, Erik Janssen, Hilde Peto, Julian Fletcher, Olivia and Giles, Graham G. Baglietto, Laura Verhoef, Senno and Tomlinson, Ian Kosma, Veli-Matti Beesley, Jonathan Greco, Dario Blomqvist, Carl Irwanto, Astrid Liu, Jianjun and Blows, Fiona M. Dawson, Sarah-Jane Margolin, Sara Mannermaa, Arto Martin, Nicholas G. Montgomery, Grant W. Lambrechts, Diether Silva, Isabel dos Santos Severi, Gianluca Hamann, Ute Pharoah, Paul Easton, Douglas F. Chang-Claude, Jenny and Yannoukakos, Drakoulis Nevanlinna, Heli Wang, Xianshu Couch, Fergus J. GENICA Consortium
- Subjects
skin and connective tissue diseases - Abstract
Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer. Cancer Res; 71(19); 6240-9. (C)2011 AACR.
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- 2011
47. Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer
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Candido dos Reis, Francisco J., primary, Lynn, Stuart, additional, Ali, H. Raza, additional, Eccles, Diana, additional, Hanby, Andrew, additional, Provenzano, Elena, additional, Caldas, Carlos, additional, Howat, William J., additional, McDuffus, Leigh-Anne, additional, Liu, Bin, additional, Daley, Frances, additional, Coulson, Penny, additional, Vyas, Rupesh J., additional, Harris, Leslie M., additional, Owens, Joanna M., additional, Carton, Amy F.M., additional, McQuillan, Janette P., additional, Paterson, Andy M., additional, Hirji, Zohra, additional, Christie, Sarah K., additional, Holmes, Amber R., additional, Schmidt, Marjanka K., additional, Garcia-Closas, Montserrat, additional, Easton, Douglas F., additional, Bolla, Manjeet K., additional, Wang, Qin, additional, Benitez, Javier, additional, Milne, Roger L., additional, Mannermaa, Arto, additional, Couch, Fergus, additional, Devilee, Peter, additional, Tollenaar, Robert A.E.M., additional, Seynaeve, Caroline, additional, Cox, Angela, additional, Cross, Simon S., additional, Blows, Fiona M., additional, Sanders, Joyce, additional, de Groot, Renate, additional, Figueroa, Jonine, additional, Sherman, Mark, additional, Hooning, Maartje, additional, Brenner, Hermann, additional, Holleczek, Bernd, additional, Stegmaier, Christa, additional, Lintott, Chris, additional, and Pharoah, Paul D.P., additional
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- 2015
- Full Text
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48. Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia
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Spurdle, Amanda B., Couch, Fergus J., Parsons, Michael T., McGuffog, Lesley, Barrowdale, Daniel, Bolla, Manjeet K., Wang, Qin, Healey, Sue, Schmutzler, Rita Katharina, Wappenschmidt, Barbara, Rhiem, Kerstin, Hahnen, Eric, Engel, Christoph, Meindl, Alfons, Ditsch, Nina, Arnold, Norbert, Plendl, Hansjoerg, Niederacher, Dieter, Sutter, Christian, Wang-Gohrke, Shan, Steinemann, Doris, Preisler-Adams, Sabine, Kast, Karin, Varon-Mateeva, Raymonda, Ellis, Steve, Frost, Debra, Platte, Radka, Perkins, Jo, Evans, D. Gareth, Izatt, Louise, Eeles, Ros, Adlard, Julian, Davidson, Rosemarie, Cole, Trevor, Scuvera, Giulietta, Manoukian, Siranoush, Bonanni, Bernardo, Mariette, Frederique, Fortuzzi, Stefano, Viel, Alessandra, Pasini, Barbara, Papi, Laura, Varesco, Liliana, Balleine, Rosemary, Nathanson, Katherine L., Domchek, Susan M., Offitt, Kenneth, Jakubowska, Anna, Lindor, Noralane, Thomassen, Mads, Jensen, Uffe Birk, Rantala, Johanna, Borg, Ake, Andrulis, Irene L., Miron, Alexander, Hansen, Thomas V. O., Caldes, Trinidad, Neuhausen, Susan L., Toland, Amanda E., Nevanlinna, Heli, Montagna, Marco, Garber, Judy, Godwin, Andrew K., Osorio, Ana, Factor, Rachel E., Terry, Mary B., Rebbeck, Timothy R., Karlan, Beth Y., Southey, Melissa, Rashid, Muhammad Usman, Tung, Nadine, Pharoah, Paul D. P., Blows, Fiona M., Dunning, Alison M., Provenzano, Elena, Hall, Per, Czene, Kamila, Schmidt, Marjanka K., Broeks, Annegien, Cornelissen, Sten, Verhoef, Senno, Fasching, Peter A., Beckmann, Matthias W., Ekici, Arif B., Slamon, Dennis J., Bojesen, Stig E., Nordestgaard, Borge G., Nielsen, Sune F., Flyger, Henrik, Chang-Claude, Jenny, Flesch-Janys, Dieter, Rudolph, Anja, Seibold, Petra, Aittomaki, Kristiina, Muranen, Taru A., Heikkila, Paivi, Blomqvist, Carl, Figueroa, Jonine, Chanock, Stephen J., Brinton, Louise, Lissowska, Jolanta, Olson, Janet E., Pankratz, Vernon S., John, Esther M., Whittemore, Alice S., West, Dee W., Hamann, Ute, Torres, Diana, Ulmer, Hans Ulrich, Rudiger, Thomas, Devilee, Peter, Tollenaar, Robert A. E. M., Seynaeve, Caroline, Van Asperen, Christi J., Eccles, Diana M., Tapper, William J., Durcan, Lorraine, Jones, Louise, Peto, Julian, dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Dwek, Miriam, Swann, Ruth, Bane, Anita L., Glendon, Gord, Mulligan, Anna M., Giles, Graham G., Milne, Roger L., Baglietto, Laura, McLean, Catriona, Carpenter, Jane, Clarke, Christine, Scott, Rodney, Brauch, Hiltrud, Bruning, Thomas, Ko, Yon-Dschun, Cox, Angela, Cross, Simon S., Reed, Malcolm W. R., Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Gronwald, Jacek, Dork, Thilo, Bogdanova, Natalia, Park-Simon, Tjoung-Won, Hillemanns, Peter, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Le Marchand, Loic, Burwinkel, Barbara, Marme, Frederik, Surovy, Harald, Yang, Rongxi, Anton-Culver, Hoda, Ziogas, Argyrios, Hooning, Maartje J., Collee, J. Margriet, Martens, John W. M., Tilanus-Linthorst, Madeleine M. A., Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volke, Stegmaier, Christa, Winqvist, Robert, Pylkas, Katri, Jukkola-Vuorinen, Arja, Grip, Mervi, Lindblom, Annika, Margolin, Sara, Joseph, Vijai, Robson, Mark, Rau-Murthy, Rohini, Gonzalez-Neira, Anna, Arias, Jose Ignacio, Zamora, Pilar, Benitez, Javier, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Peterlongo, Paolo, Zaffaroni, Daniela, Barile, Monica, Capra, Fabio, Radice, Paolo, Teo, Soo H., Easton, Douglas F., Antoniou, Antonis C., Chenevix-Trench, Georgia, Goldgar, David E., Spurdle, Amanda B., Couch, Fergus J., Parsons, Michael T., McGuffog, Lesley, Barrowdale, Daniel, Bolla, Manjeet K., Wang, Qin, Healey, Sue, Schmutzler, Rita Katharina, Wappenschmidt, Barbara, Rhiem, Kerstin, Hahnen, Eric, Engel, Christoph, Meindl, Alfons, Ditsch, Nina, Arnold, Norbert, Plendl, Hansjoerg, Niederacher, Dieter, Sutter, Christian, Wang-Gohrke, Shan, Steinemann, Doris, Preisler-Adams, Sabine, Kast, Karin, Varon-Mateeva, Raymonda, Ellis, Steve, Frost, Debra, Platte, Radka, Perkins, Jo, Evans, D. Gareth, Izatt, Louise, Eeles, Ros, Adlard, Julian, Davidson, Rosemarie, Cole, Trevor, Scuvera, Giulietta, Manoukian, Siranoush, Bonanni, Bernardo, Mariette, Frederique, Fortuzzi, Stefano, Viel, Alessandra, Pasini, Barbara, Papi, Laura, Varesco, Liliana, Balleine, Rosemary, Nathanson, Katherine L., Domchek, Susan M., Offitt, Kenneth, Jakubowska, Anna, Lindor, Noralane, Thomassen, Mads, Jensen, Uffe Birk, Rantala, Johanna, Borg, Ake, Andrulis, Irene L., Miron, Alexander, Hansen, Thomas V. O., Caldes, Trinidad, Neuhausen, Susan L., Toland, Amanda E., Nevanlinna, Heli, Montagna, Marco, Garber, Judy, Godwin, Andrew K., Osorio, Ana, Factor, Rachel E., Terry, Mary B., Rebbeck, Timothy R., Karlan, Beth Y., Southey, Melissa, Rashid, Muhammad Usman, Tung, Nadine, Pharoah, Paul D. P., Blows, Fiona M., Dunning, Alison M., Provenzano, Elena, Hall, Per, Czene, Kamila, Schmidt, Marjanka K., Broeks, Annegien, Cornelissen, Sten, Verhoef, Senno, Fasching, Peter A., Beckmann, Matthias W., Ekici, Arif B., Slamon, Dennis J., Bojesen, Stig E., Nordestgaard, Borge G., Nielsen, Sune F., Flyger, Henrik, Chang-Claude, Jenny, Flesch-Janys, Dieter, Rudolph, Anja, Seibold, Petra, Aittomaki, Kristiina, Muranen, Taru A., Heikkila, Paivi, Blomqvist, Carl, Figueroa, Jonine, Chanock, Stephen J., Brinton, Louise, Lissowska, Jolanta, Olson, Janet E., Pankratz, Vernon S., John, Esther M., Whittemore, Alice S., West, Dee W., Hamann, Ute, Torres, Diana, Ulmer, Hans Ulrich, Rudiger, Thomas, Devilee, Peter, Tollenaar, Robert A. E. M., Seynaeve, Caroline, Van Asperen, Christi J., Eccles, Diana M., Tapper, William J., Durcan, Lorraine, Jones, Louise, Peto, Julian, dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Dwek, Miriam, Swann, Ruth, Bane, Anita L., Glendon, Gord, Mulligan, Anna M., Giles, Graham G., Milne, Roger L., Baglietto, Laura, McLean, Catriona, Carpenter, Jane, Clarke, Christine, Scott, Rodney, Brauch, Hiltrud, Bruning, Thomas, Ko, Yon-Dschun, Cox, Angela, Cross, Simon S., Reed, Malcolm W. R., Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Gronwald, Jacek, Dork, Thilo, Bogdanova, Natalia, Park-Simon, Tjoung-Won, Hillemanns, Peter, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Le Marchand, Loic, Burwinkel, Barbara, Marme, Frederik, Surovy, Harald, Yang, Rongxi, Anton-Culver, Hoda, Ziogas, Argyrios, Hooning, Maartje J., Collee, J. Margriet, Martens, John W. M., Tilanus-Linthorst, Madeleine M. A., Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volke, Stegmaier, Christa, Winqvist, Robert, Pylkas, Katri, Jukkola-Vuorinen, Arja, Grip, Mervi, Lindblom, Annika, Margolin, Sara, Joseph, Vijai, Robson, Mark, Rau-Murthy, Rohini, Gonzalez-Neira, Anna, Arias, Jose Ignacio, Zamora, Pilar, Benitez, Javier, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Peterlongo, Paolo, Zaffaroni, Daniela, Barile, Monica, Capra, Fabio, Radice, Paolo, Teo, Soo H., Easton, Douglas F., Antoniou, Antonis C., Chenevix-Trench, Georgia, and Goldgar, David E.
- Abstract
Introduction: The distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling. Methods: Selection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the likelihood of mutation status by histopathological markers were derived using a Mantel-Haenszel approach. Results: ER-positive phenotype negatively predicted BRCA1 mutation status, irrespective of grade (LRs from 0.08 to 0.90). ER-negative grade 3 histopathology was more predictive of positive BRCA1 mutation status in women 50 years or older (LR = 4.13 (3.70 to 4.62)) versus younger than 50 years (LR = 3.16 (2.96 to 3.37)). For BRCA2, ER-positive grade 3 phenotype modestly predicted positive mutation status irrespective of age (LR = 1.7-fold), whereas ER-negative grade 3 features modestly predicted positive mutation status at 50 years or older (LR = 1.54 (1.27 to 1.88)). Triple-negative tumor status was highly predictive of BRCA1 mutation status for women younger than 50 years (LR = 3.73 (3.43 to 4.05)) and 50 years or older (LR = 4.41 (3.86 to 5.04)), and modestly predictive of positive BRCA2 mutation status in women 50 years or older (LR = 1.79 (1.42 to 2.24)
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- 2014
49. Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium
- Author
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Howat, William J, primary, Blows, Fiona M, additional, Provenzano, Elena, additional, Brook, Mark N, additional, Morris, Lorna, additional, Gazinska, Patrycja, additional, Johnson, Nicola, additional, McDuffus, Leigh-Anne, additional, Miller, Jodi, additional, Sawyer, Elinor J, additional, Pinder, Sarah, additional, van Deurzen, Carolien H M, additional, Jones, Louise, additional, Sironen, Reijo, additional, Visscher, Daniel, additional, Caldas, Carlos, additional, Daley, Frances, additional, Coulson, Penny, additional, Broeks, Annegien, additional, Sanders, Joyce, additional, Wesseling, Jelle, additional, Nevanlinna, Heli, additional, Fagerholm, Rainer, additional, Blomqvist, Carl, additional, Heikkilä, Päivi, additional, Ali, H Raza, additional, Dawson, Sarah-Jane, additional, Figueroa, Jonine, additional, Lissowska, Jolanta, additional, Brinton, Louise, additional, Mannermaa, Arto, additional, Kataja, Vesa, additional, Kosma, Veli-Matti, additional, Cox, Angela, additional, Brock, Ian W, additional, Cross, Simon S, additional, Reed, Malcolm W, additional, Couch, Fergus J, additional, Olson, Janet E, additional, Devillee, Peter, additional, Mesker, Wilma E, additional, Seyaneve, Caroline M, additional, Hollestelle, Antoinette, additional, Benitez, Javier, additional, Perez, Jose Ignacio Arias, additional, Menéndez, Primitiva, additional, Bolla, Manjeet K, additional, Easton, Douglas F, additional, Schmidt, Marjanka K, additional, Pharoah, Paul D, additional, Sherman, Mark E, additional, and García-Closas, Montserrat, additional
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- 2014
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50. Inclusion of KI67 significantly improves performance of the PREDICT prognostication and prediction model for early breast cancer
- Author
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Wishart, Gordon C, primary, Rakha, Emad, additional, Green, Andrew, additional, Ellis, Ian, additional, Ali, Hamid Raza, additional, Provenzano, Elena, additional, Blows, Fiona M, additional, Caldas, Carlos, additional, and Pharoah, Paul DP, additional
- Published
- 2014
- Full Text
- View/download PDF
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