41 results on '"Blow AJ"'
Search Results
2. Civilian employment among recently returning Afghanistan and Iraq National Guard veterans.
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Burnett-Zeigler I, Valenstein M, Ilgen M, Blow AJ, Gorman LA, Zivin K, Burnett-Zeigler, Inger, Valenstein, Marcia, Ilgen, Mark, Blow, Adrian J, Gorman, Lisa A, and Zivin, Kara
- Abstract
Objective: National Guard service members face deactivation from active duty soon after they return to the United States and rapid entry into the civilian workforce; therefore, it is important to examine employment among these Veterans.Methods: The sample included 585 National Guard service members. Bivariate and multivariable analyses were conducted examining the associations between mental health symptoms, alcohol use, number of deployments, and combat exposure with employment status and full-time versus part-time employment as outcomes.Results: Forty-one percent of National Guard service members were employed 45 to 60 days following demobilization. Among those who were employed, 79% were employed full-time. Age, family income, and combat exposure were associated with employment; income and health status were associated with part-time versus full-time employment.Conclusions: Mental health status may not be strongly associated with initiating civilian employment among National Guard service members; however, better mental health status is associated with being employed full-time versus part-time. [ABSTRACT FROM AUTHOR]- Published
- 2011
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3. What predicts personal growth following a deployment? An examination of National Guard soldiers through the lens of posttraumatic growth.
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Farero AM, Blow AJ, Bowles RP, Gorman Ufer L, Kees M, and Guty D
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- Humans, Male, Adult, Female, Young Adult, Military Deployment, Social Support, Longitudinal Studies, Stress Disorders, Post-Traumatic psychology, Military Personnel psychology, Posttraumatic Growth, Psychological
- Abstract
National Guard soldiers experience unique reintegration challenges. In addition to managing the consequences of combat-related trauma, they also navigate multiple transitions between military and civilian life. Despite these obstacles, many soldiers report positive outcomes and personal growth due to deployment, a phenomenon most commonly referred to in the literature as posttraumatic growth (PTG). The current study explored PTG in National Guard soldiers using a multidimensional longitudinal approach, with the goal of validating reports of PTG in soldiers. Data were collected from National Guard soldiers at pre-deployment, reintegration, one year post-deployment and two years post-deployment. Informed by PTG theory, three PTG constructs were measured (perceived ability to handle stress, social support seeking, and purpose in life) at each of the four time points, with increases in these constructs indicating growth. Potential predictors of growth in these PTG constructs were also explored. Results from a repeated measure latent profile analysis indicated that PTG did occur in certain soldiers, and that higher optimism and less severe PTSD symptoms predict this growth. These findings emphasize the importance of making efforts to facilitate PTG in soldiers.
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- 2024
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4. Training of interventionists and cultural adaptation procedures: A systematic review of culturally adapted evidence-based parenting programs in Africa.
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Asiimwe R, Dwanyen L, Subramaniam S, Kasujja R, and Blow AJ
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- Humans, Translations, Language, Africa, Parenting, Parents education
- Abstract
There has been an increase in the implementation of evidence-based parenting programs from high-income countries to several African countries. In this review, we systematically evaluated intervention studies of culturally adapted parenting programs in nine African countries with the objective of examining the quality of training for interventionists and cultural adaptation procedures. A total of 18 studies, obtained from an electronic search of 6 databases, met the inclusion criteria and were evaluated following PRISMA guidelines. The Ecological Validity Model was adopted to organize data on cultural adaptation procedures. Sixteen of the 18 studies reported information regarding the clinical training of interventionists and the cultural adaptations undertaken. Live and interactive workshops were the most common format used to train interventionists in the focal intervention. Overall, cultural adaptations in most studies included translation of intervention protocols into the local language. However, studies varied in the way cultural adaptation procedures were reported with some studies failing to report on cultural adaptation procedures. Concurring with previous literature, attending to issues of culture, power, privilege, access, sustainability, and other relevant concepts to increase the cultural relevance is highly encouraged in parent intervention studies in Africa. This review provides a baseline upon which future training and adaptation procedures can be built., (© 2022 The Authors. Family Process published by Wiley Periodicals LLC on behalf of Family Process Institute.)
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- 2023
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5. Affair recovery: Exploring similarities and differences of injured and involved partners.
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Mitchell EA, Wittenborn AK, Timm TM, and Blow AJ
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- Communication, Humans, Interpersonal Relations, Marriage, Sexual Behavior, Sexual Partners
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Infidelity is associated with negative effects on couples' relationships, yet some couples are able to overcome these and rebuild their relationship. Few studies have examined this process for couples who stay together after an affair. With a sample of 18 individuals (nine couples), this study explored similarities and differences between injured (i.e., partner who did not have the affair) and involved (i.e., partner who had the affair) partners' experiences across three categories of affair recovery: (a) commitment to the relationship, (b) dimensions of the attachment bond, and (c) healing process. Thematic analysis revealed similarities amongst both partners across categories: (a) frequent and quality communication, (b) mechanisms for rebuilding safety and trust, and (c) the importance of forgiveness. However, partners' experiences varied regarding (a) responses to needs for comfort, (b) their sexual relationship, and (c) responding to reminders. A discussion of these key findings and clinical implications are included., (© 2021 American Association for Marriage and Family Therapy.)
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- 2022
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6. National Guard Couples Communicating During Deployment: The Challenge of Effective Connection.
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Blow AJ, Farero AM, Ufer LG, Kees M, and Guty D
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Communication during a combat deployment has changed significantly in current times. Couples can now communicate with each other frequently and through multiple modes. Despite this greater availability of communication options, there remain unanswered questions related to how healthy deployment communication is best achieved between couples, particularly regarding navigating the uncertainty of deployment. In this qualitative study, we report on the experiences of 31 National Guard couples who endured a combat deployment in support of Operation Enduring Freedom. Couples were interviewed three months after the soldier returned from deployment. Through the lens of relational turbulence theory, we provide a conceptual framework related to effective and non-effective deployment communication, along with structural communication barriers in the military that may negatively affect the mental well-being of partners. Finally, we provide recommendations to guide couples through these difficult deployments., Competing Interests: Conflict of interestThe authors have no relevant financial or non-financial interests to disclose., (© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.)
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- 2022
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7. Expanding our international reach: Trends in the development of systemic family therapy training and implementation in Africa.
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Asiimwe R, Lesch E, Karume M, and Blow AJ
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- Africa, Forecasting, Humans, Family Therapy
- Abstract
Family therapy is growing around the world including in many parts of Africa. Although the African continent has many mental and family health needs that family therapists are well-suited to treat, barriers to the widespread application of family therapy on the African continent remain. In this article, we review the current state of systemic family therapy (SFT) in Africa. Drawing from existing literature, we discuss past, current, and future trends, including challenges related to the training and implementation of SFT in Africa. We devote sections of this article to discussing the historical and cultural context, including the fit for family therapy, along with ongoing initiatives in various African countries, using examples from three African countries. We emphasize and discuss the influence of Western models of family therapy in informing family therapy research, training, and implementation in Africa and discuss implications for the African context., (© 2021 American Association for Marriage and Family Therapy.)
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- 2021
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8. Health-Related Quality of Life: Longitudinal Analysis From the Time of Breast Biopsy Into the Post-treatment Period.
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Boivin MJ, Sikorskii A, Haan P, Smith SS, Symonds LL, Khattree R, Giordani B, Blow AJ, and Osuch JR
- Abstract
Background: The physical, psychological, social, and spiritual quality of life (QoL) may be affected by breast cancer diagnosis and treatment, with mixed findings for psychological quality of life and cognitive ability performance. The present study aimed to evaluate QoL in women over 1 year from biopsy for a breast abnormality. Methods: Self-reported measures of physical, psychological, social, and spiritual QoL were obtained after biopsy results but prior to treatment initiation (baseline), 4 and 12 months later. CogState computerized neuropsychological screening battery also provided an evaluation of psychological QoL. Three groups of women including those with benign biopsy results, those with malignancy treated with chemotherapy, and those with malignancy not treated with chemotherapy were compared at 4 and 12 months after adjusting for baseline to isolate the effects of treatment. Additional covariates included are age, level of education, and income. Results: Benign biopsy results group included 72 women, whereas malignancy was found in 87 women of whom 33 were treated with chemotherapy and 54 without chemotherapy. At the time of diagnosis, women with cancer had worse psychological and social QoL but better spiritual QoL than those with benign biopsy results. Only CogState monitoring accuracy was worse for women with cancer compared with the controls at the time of biopsy results. After adjusting for QoL at baseline, women treated for cancer had worse physical and social QoL at 4 and 12 months later. Psychological well-being was worse for women with cancer at 4th month but improved at 1 year. No differences in cognition were found at 4 and 12 months when adjusted for baseline cognition and covariates. Discussion: Breast cancer is a traumatic life event for women, affecting psychological and social QoL domains, yet increasing spiritual QoL. Later, cancer treatment worsens physical, psychological, and social QoL compared with those without cancer. Conclusions: These findings suggest that interventions to improve psychological QoL may be especially important at the time of cancer diagnosis, while interventions to improve physical well-being are the most needed during and following cancer treatment. Support to improve social QoL is needed from the time of diagnosis into post-treatment survivorship., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Boivin, Sikorskii, Haan, Smith, Symonds, Khattree, Giordani, Blow and Osuch.)
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- 2021
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9. Therapeutic Utility of Discussing Therapist/Client Intersectionality in Treatment: When and How?
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PettyJohn ME, Tseng CF, and Blow AJ
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- Adult, Cooperative Behavior, Female, Humans, Male, Social Identification, Therapeutic Alliance, Health Personnel psychology, Mental Disorders therapy, Professional-Patient Relations, Psychotherapy methods
- Abstract
The impact of the therapeutic alliance on positive clinical outcomes has been established in the literature; however, literature is lacking on how the intersection of therapist and client identities influences this process. We propose that the relational intersectionality resulting from similarities or differences in therapist and client identities has the potential to impact the bonds, tasks, and goals of treatment (key components of the therapeutic alliance; Bordin, 1979) depending on how it is addressed or avoided in therapy. In this paper, we present a model containing pragmatic steps therapists can follow to navigate these conversations with clients in a way that is therapeutically beneficial and culturally sensitive and attuned. Additionally, we provide suggestions for using the proposed model to train new student therapists (or expose experienced therapists) to ideas of intersectionality and social justice by reflecting on the intersection of their own identities, acknowledging dynamics of power and oppression, and understanding how this could shape their relationship with clients., (© 2019 Family Process Institute.)
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- 2020
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10. Intimate Relationships Buffer Suicidality in National Guard Service Members: A Longitudinal Study.
- Author
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Blow AJ, Farero A, Ganoczy D, Walters H, and Valenstein M
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- Adult, Anxiety Disorders psychology, Depression psychology, Female, Humans, Longitudinal Studies, Male, Mental Health, Middle Aged, Midwestern United States, Stress Disorders, Post-Traumatic psychology, Surveys and Questionnaires, Young Adult, Interpersonal Relations, Military Personnel psychology, Suicide psychology
- Abstract
Objective: Members of the U.S. military are at a high suicide risk. While studies have examined predictors of suicide in the U.S. military, more studies are needed which examine protective factors for suicide. Informed by the interpersonal theory of suicide, this study examined the strength of the intimate relationship and its role as a buffer of suicidality in National Guard service members., Method: A total of 712 National Guard residing in a Midwestern state, who had all recently returned home from a deployment, took part in this study and completed surveys at 6 and 12 months postdeployment. They were assessed on suicide risk, mental health (depression, post-traumatic stress disorder, anxiety), and relationship satisfaction., Results: Lower relationship satisfaction and more depressive symptoms at the 6-month assessment were significantly related to greater suicide risk at 12 months. Each interaction between couple satisfaction and three mental health variables (PTSD, depression, and anxiety) at the 6-month assessment was significantly associated with suicide risk at 12 months., Conclusions: The strength of the intimate relationship serves as a buffer for suicide in National Guard service members who have PTSD, anxiety, or depression. Interventions that strengthen these intimate relationships could reduce suicide in service members., (© 2018 The American Association of Suicidology.)
- Published
- 2019
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11. Establishing Safety in Emotionally Focused Couple Therapy: A Single-Case Process Study.
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Welch TS, Lachmar EM, Leija SG, Easley T, Blow AJ, and Wittenborn AK
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- Adaptation, Psychological, Adult, Female, Humans, Interpersonal Relations, Male, Middle Aged, Personal Satisfaction, Couples Therapy methods, Family Conflict psychology, Marriage psychology, Object Attachment
- Abstract
Emotionally Focused Couple Therapy (EFT) is an effective approach to working with distressed couples. It is not only effective in reducing relationship distress, but also in successfully maintaining gains over time. In the current study, we sought to understand the therapy processes that result in the creation of safety during stage one of EFT. Safety is a key ingredient in stage one, setting the stage for deeper interpersonal and intrapsychic work in later stages of treatment. In order to achieve the study aim, we analyzed video recordings of the first six sessions of a single couple case from an EFT randomized controlled trial. Using a theory building case study approach, results reveal that all expected components related to the creation of safety were achieved. Additional findings from our analyses indicate that the therapist was highly active, especially in seizing key moments in the therapy provided by this particular case, which shifted the couple in the direction of safety and deescalated their interactional cycle. Implications of key findings are discussed., (© 2019 American Association for Marriage and Family Therapy.)
- Published
- 2019
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12. The Profession of Couple, Marital, and Family Therapy (CMFT): Defining Ourselves and Moving Forward.
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Wampler KS, Blow AJ, McWey LM, Miller RB, and Wampler RS
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- Adolescent, Adult, Child, Couples Therapy standards, Evidence-Based Practice standards, Family Therapy standards, Humans, Marital Therapy methods, Marital Therapy standards, Couples Therapy methods, Evidence-Based Practice methods, Family Therapy methods
- Abstract
The field of Couple, Marital, and Family Therapy (CMFT) has evolved and strengthened, but we still have work to do when it comes to identity, comprehensive scholarly resources, empirical support, and name brand recognition. We explore the reasons for these challenges and propose ways to address them: embracing the interdisciplinary nature of the field, consistently organizing treatment effectiveness by problem rather than by intervention model, continuing innovation in theory development, and utilizing more diverse and meaningful research methods. This approach provides a more accurate representation of the scope of practice of CMFTs, the range of mental and physical health problems we address, and the depth and extent of the existing research on the effectiveness of relational therapies., (© 2017 American Association for Marriage and Family Therapy.)
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- 2019
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13. Strengthening Clinical Research in Marriage and Family Therapy: Challenges and Multilevel Solutions.
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Wittenborn AK, Blow AJ, Holtrop K, and Parra-Cardona JR
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- Humans, Biomedical Research economics, Biomedical Research education, Biomedical Research methods, Biomedical Research standards, Family Therapy economics, Family Therapy education, Family Therapy methods, Family Therapy standards, Marital Therapy economics, Marital Therapy education, Marital Therapy methods, Marital Therapy standards
- Abstract
There is a critical need for high-quality and accessible treatments to improve mental health. Yet, there are indications that the research being conducted by contemporary marriage and family therapy (MFT) scholars focuses less on advancing and disseminating clinical interventions than in previous decades. In this article, we describe challenges to increasing rigorous clinical research in MFT. We use systems mapping and the intervention-level framework to identify strategic goals designed to drive innovation in clinical research in the field. It is our hope this article encourages dialog and action among MFT stakeholder groups to support clinical science that will improve the health and functioning of families., (© 2018 American Association for Marriage and Family Therapy.)
- Published
- 2019
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14. Couples Coping Through Deployment: Findings From a Sample of National Guard Families.
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Blow AJ, Bowles RP, Farero A, Subramaniam S, Lappan S, Nichols E, Gorman L, Kees M, and Guty D
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- Adult, Female, Humans, Longitudinal Studies, Male, Middle Aged, Young Adult, Adaptation, Psychological, Anxiety psychology, Depression psychology, Military Personnel psychology, Parenting psychology, Spouses psychology, Stress Disorders, Post-Traumatic psychology, Stress, Psychological psychology
- Abstract
Objective: Military families face numerous changes and stresses as they negotiate deployments and other life transitions. How they cope with these events is an important part of their overall well-being and resilience. This longitudinal study on coping in a sample of National Guard couples examined the association between the predeployment coping (active vs. avoidant) of each in the relationship, and their own and their significant others' mental health (anxiety, depression, posttraumatic stress disorder [PTSD]) and family well-being (dyadic adjustment and parenting stress) postdeployment., Method: A total of 238 matched couples completed the predeployment survey, 143 matched couples completed the post, with 122 matched couples completing both pre- and postdeployment surveys., Results: While active coping was not significantly associated with any outcomes, predeployment avoidant coping in both soldiers and significant others was associated with increased anxiety, PTSD, and depression post deployment (actor effects). Additionally, soldier avoidant coping predeployment was associated with increased parenting stress for soldiers, while significant other avoidant coping predeployment was associated with increased relationship distress for significant others (actor effects). Finally, significant other avoidant coping predeployment was associated with higher parenting distress for soldiers postdeployment (partner effect)., Conclusion: Findings suggest that interventions are needed to combat avoidant coping (behavioral disengagement, denial, substance abuse) predeployment because this way of coping is strongly related to negative outcomes. In addition, those who work clinically with these families should work to reduce avoidant coping strategies and any familial dynamics exacerbated by this way of coping., (© 2017 Wiley Periodicals, Inc.)
- Published
- 2017
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15. The Therapist's Role in Effective Marriage and Family Therapy Practice: The Case for Evidence Based Therapists.
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Blow AJ and Karam EA
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- Evidence-Based Practice, Family Therapy education, Family Therapy standards, Humans, Insurance, Health, Reimbursement, Marital Therapy education, Marital Therapy standards, Quality of Health Care, Clinical Competence, Family Therapy organization & administration, Marital Therapy organization & administration, Professional Role, Professional-Patient Relations
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In this paper we argue that the therapist is a crucial change variable in psychotherapy as a whole and in couple, marital, and family therapy specifically. Therapists who work with complex systems require more skills to negotiate demanding therapy contexts. Yet, little is known about what differentiates effective couple, marital, and family therapists from those who are less effective, what innate therapy skills they possess, how they learn, and how they operationalize their knowledge in the therapy room. We discuss the need to emphasize evidence based therapists (as opposed to therapies), and implications of the importance of the role therapists for training, practice, research priorities, and policy.
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- 2017
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16. The Therapist's Role in Effective Therapy: Three Key Priorities for Research.
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Blow AJ
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- Humans, Psychotherapy education, Treatment Outcome, Professional Role, Professional-Patient Relations, Psychotherapy organization & administration, Quality of Health Care organization & administration, Research organization & administration
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- 2017
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17. Postdeployment Suicide Risk Increases Over a 6-month Period: Predictors of Increased Risk among Midwestern Army National Guard Soldiers.
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Kim HM, Levine DS, Pfeiffer PN, Blow AJ, Marchiondo C, Walters H, and Valenstein M
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- Adolescent, Adult, Female, Humans, Iraq, Male, Middle Aged, Odds Ratio, Risk Assessment statistics & numerical data, Risk Factors, Stress Disorders, Post-Traumatic diagnosis, Surveys and Questionnaires, Young Adult, Military Personnel psychology, Suicide
- Abstract
National Guard (NG) soldiers returning from deployments in Iraq and Afghanistan were surveyed at 6 and 12 months following their return (N = 970). The overall prevalence of suicide risk at 6 and 12 months following their return was assessed, as were changes in suicide risk among soldiers initially at high or low risk. Factors associated with changes in risk were assessed. The percentage of NG soldiers with high suicide risk increased from 6.8% at 6 months to 9.2% at 12 months (odds ratio = 1.7, p = .02). In the 882 soldiers initially at low risk, 5.9% (52/882) became high risk at 12 months; in the 64 soldiers initially at high risk, 46.9% (30/64) became low risk at 12 months. Initial levels of depressive symptoms were predictive of changing to high risk; this association appeared to be partially explained by soldier reports of increased search in the meaning in life and higher levels of perceived stress. Because suicide risk increases over the first 12 months, continued risk assessments during this time period should be considered. Supporting soldiers to find meaning in their life after deployment and enhancing their capacity to cope with perceived stress may help prevent increases in suicide risk over time., (© 2016 The American Association of Suicidology.)
- Published
- 2017
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18. A Comparative Case Study of Risk, Resiliency, and Coping Among Injured National Guard.
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Gorman LA, Huebner AJ, Hirschfeld MK, Sankar S, Blow AJ, Guty D, Kees M, and Ketner JS
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- Adaptation, Psychological, Adult, Afghan Campaign 2001-, Afghanistan, Case-Control Studies, Cohort Studies, Emotional Adjustment, Health Services Accessibility standards, Humans, Male, Middle Aged, Qualitative Research, Risk, Self Report, Social Support, Stress Disorders, Post-Traumatic epidemiology, Stress Disorders, Post-Traumatic etiology, Stress Disorders, Post-Traumatic psychology, Stress, Psychological etiology, Surveys and Questionnaires, United States, United States Department of Veterans Affairs organization & administration, Family Relations psychology, Military Personnel psychology, Stress, Psychological complications, United States Department of Veterans Affairs standards, Warfare
- Abstract
An injury during deployment disrupts family and life functioning. The purpose of the present study was to provide an in-depth examination of three injured National Guard soldiers showing how differential experiences of navigating multiple systems to obtain treatment for injury resulted in different adjustment trajectories for these soldiers and their families. A comparative case study examined three families where a soldier's injury was a central theme of family adjustment. Qualitative data were drawn from interviews conducted conjointly with both the soldier and spouse to provide an in-depth perspective of adjustment, meaning, and resource utilization patterns. In addition, survey data were collected at three time points in the deployment cycle (predeployment, 90 days post, and 1 year). These data were integrated into the case analysis, including mental health, marital relationship, treatment history, and characteristics of resilience. Study findings suggest that a delay in diagnosis, wait time for treatment, and the lack of comprehensive formal and financial support for a soldier following nonhostile injury lead to a pileup of stressors that are detrimental to the soldier's physical and mental health, financial stability, and family well-being. Further study is needed to understand how these system level issues impede resilience among National Guard families., (Reprint & Copyright © 2016 Association of Military Surgeons of the U.S.)
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- 2016
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19. Socioeconomic Status and Mental Health Service Use Among National Guard Soldiers.
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Sripada RK, Richards SK, Rauch SA, Walters HM, Ganoczy D, Bohnert KM, Gorman LA, Kees M, Blow AJ, and Valenstein M
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- Adult, Educational Status, Female, Humans, Income, Male, Middle Aged, Socioeconomic Factors, United States epidemiology, Young Adult, Mental Disorders epidemiology, Mental Disorders therapy, Mental Health Services statistics & numerical data, Military Personnel psychology, Military Personnel statistics & numerical data
- Abstract
Objective: Convergent evidence suggests that low socioeconomic status (SES) may be related to reduced mental health service use. However, this relationship has not been tested in the National Guard (NG) population, in which the prevalence of mental health symptoms is high., Methods: Surveys were completed by 1,262 NG soldiers. SES was measured by education and income. Adjusted multivariable regression models assessed associations between SES, overall service use, and use of specific types of services., Results: SES was not associated with overall use but was associated with use of certain types of services. Higher SES was associated with lower likelihood of psychotropic medication use (odds ratio=.83, 95% confidence interval=.72-.96), and higher SES strengthened the positive relationship between PTSD and use of individual therapy., Conclusions: Higher SES may increase the use of individual therapy among soldiers with PTSD. Barriers to care among individuals with low SES merit continued attention and outreach efforts.
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- 2015
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20. Strengthening the systemic ties that bind: integrating common factors into marriage and family therapy curricula.
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Karam EA, Blow AJ, Sprenkle DH, and Davis SD
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- Humans, Curriculum standards, Family Therapy education, Marital Therapy education
- Abstract
Specific models guide the training of marriage and family therapists (MFTs) as they offer both structure and organization for both therapists and clients. Learning models may also benefit therapists-in-training by instilling confidence and preventing atheoretical eclecticism. The moderate common factors perspective argues that models are essential, but should not be taught as "the absolute truth," given there is no evidence for relative efficacy of one empirically validated model versus another, and no single model works in all instances. The following article provides a blueprint for infusing a common factors perspective into MFT programmes by reviewing innovations in course design, outlining specific teaching strategies, and highlighting potential implementation challenges., (© 2014 American Association for Marriage and Family Therapy.)
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- 2015
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21. Reported barriers to mental health care in three samples of U.S. Army National Guard soldiers at three time points.
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Valenstein M, Gorman L, Blow AJ, Ganoczy D, Walters H, Kees M, Pfeiffer PN, Kim HM, Lagrou R, Wadsworth SM, Rauch SA, and Dalack GW
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- Adolescent, Adult, Career Mobility, Depression diagnosis, Depression therapy, Female, Health Knowledge, Attitudes, Practice, Humans, Interpersonal Relations, Male, Middle Aged, Psychiatric Status Rating Scales, Stress Disorders, Post-Traumatic diagnosis, Stress Disorders, Post-Traumatic therapy, Time Factors, United States, Young Adult, Health Services Accessibility, Mental Health Services statistics & numerical data, Military Personnel psychology, Patient Acceptance of Health Care, Social Stigma
- Abstract
The military community and its partners have made vigorous efforts to address treatment barriers and increase appropriate mental health services use among returning National Guard soldiers. We assessed whether there were differences in reports of treatment barriers in 3 categories (stigma, logistics, or negative beliefs about treatment) in sequential cross-sectional samples of U.S. soldiers from a Midwestern Army National Guard Organization who were returning from overseas deployments. Data were collected during 3 time periods: September 2007-August 2008 (n = 333), March 2009-March 2010 (n = 884), and August 2011-August 2012 (n = 737). In analyses using discretized time periods and in trend analyses, the percentages of soldiers endorsing negative beliefs about treatment declined significantly across the 3 sequential samples (19.1%, 13.9%, and 11.1%). The percentages endorsing stigma barriers (37.8%, 35.2%, 31.8%) decreased significantly only in trend analyses. Within the stigma category, endorsement of individual barriers regarding negative reactions to a soldier seeking treatment declined, but barriers related to concerns about career advancement did not. Negative treatment beliefs were associated with reduced services use (OR = 0.57; 95% CI [0.33, 0.97])., (Published 2014. This article is a US Government work and is in the public domain in the USA.)
- Published
- 2014
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22. Hazardous drinking and family functioning in National Guard veterans and spouses postdeployment.
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Blow AJ, Gorman L, Ganoczy D, Kees M, Kashy DA, Valenstein M, Marcus SM, Fitzgerald HE, and Chermack S
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- Adolescent, Adult, Alcoholism etiology, Combat Disorders complications, Depression etiology, Female, Humans, Male, Middle Aged, United States, Young Adult, Alcoholism psychology, Combat Disorders psychology, Depression psychology, Family Relations, Military Personnel psychology, Spouses psychology, Veterans psychology
- Abstract
The current study examined rates of alcohol misuse among National Guard (NG) service members and their spouses/partners, concordance of drinking behaviors among couples, and the effects of alcohol misuse, depression, and posttraumatic stress disorder (PTSD) on three measures of family functioning. This study is important because it addresses the topics of heavy drinking and family functioning in an at-risk population-NG service members returning from a combat zone deployment. We surveyed NG service members (1,143) and their partners (674) 45-90 days after returning from a military deployment. Service member rates of hazardous drinking were 29.2% and spouses/partners 10.7%. Of the 661 linked couples, 26.2% were discrepant where only one member met the criteria for hazardous drinking and 5.4% were congruent for alcohol misuse where both members met hazardous drinking criteria. Service members belonging to either congruent or discrepant drinking groups were more distressed in their marriages/relationships than those in the nonhazardous group. In dyadic analyses, an unexpected partner effect was found for parenting outcomes; that is, when service members drink more, their spouses/partners are less stressed when it comes to parenting. Importantly, both service member and spouse/partner depression was significantly associated with negative family outcomes. Results from this study suggest that when working with these families, it is important to understand the drinking status of both soldier and spouse and to treat depression in addition to alcohol misuse., ((PsycINFO Database Record (c) 2013 APA, all rights reserved).)
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- 2013
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23. Peers and peer-based interventions in supporting reintegration and mental health among National Guard soldiers: a qualitative study.
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Pfeiffer PN, Blow AJ, Miller E, Forman J, Dalack GW, and Valenstein M
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- Adult, Female, Humans, Male, Mental Health Services, Middle Aged, Social Stigma, United States, Young Adult, Health Services Accessibility, Mental Disorders therapy, Military Personnel psychology, Patient Acceptance of Health Care, Peer Group
- Abstract
National Guard soldiers experience high levels of mental health symptoms following deployment to Iraq and Afghanistan, yet many do not seek treatment. We interviewed 30 National Guard soldiers with prior deployments to Iraq or Afghanistan to assess mental health treatment barriers and the role of peers in treatment engagement. Interview transcripts were analyzed by a multidisciplinary research team using techniques drawn from grounded theory. The following themes were identified: (1) personal acceptance of having a mental health problem rather than treatment access is the major barrier to treatment entry; (2) tightly connected, supportive peer networks can decrease stigma related to mental health problems and encourage treatment; however, soldiers in impoverished or conflicted peer networks are less likely to receive these benefits; and (3) soldiers are generally positive about the idea of peer-based programs to improve treatment engagement, although they note the importance of leadership support, peer assignment, and unit specialty in implementing these programs. We conclude that some, but not all, naturally occurring peer networks serve to overcome stigma and encourage mental health treatment seeking by soldiers. Formal peer-based programs may assist soldiers not sufficiently benefitting from natural peer networks, although there are barriers to implementation.
- Published
- 2012
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24. Interpersonal relatedness and psychological functioning following traumatic brain injury: implications for marital and family therapists.
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Bay EH, Blow AJ, and Yan XE
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- Adult, Aged, Brain Injuries rehabilitation, Comorbidity, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Social Identification, Social Support, Socioeconomic Factors, Stress, Psychological epidemiology, Stress, Psychological psychology, Young Adult, Brain Injuries epidemiology, Brain Injuries psychology, Conflict, Psychological, Interpersonal Relations, Marital Therapy methods, Mental Disorders epidemiology, Mental Disorders psychology
- Abstract
Recovery from a mild-to-moderate traumatic brain injury (TBI) is a challenging process for injured persons and their families. Guided by attachment theory, we investigated whether relationship conflict, social support, or sense of belonging were associated with psychological functioning. Community-dwelling persons with TBI (N = 75) and their relatives/significant others (N = 74) were surveyed on relationship variables, functional status, and TBI symptom severity. Results from this cross-sectional study revealed that only sense of belonging was a significant predictor of postinjury psychological functioning, although interpersonal conflict approached significance. No relevant preinjury or injury-related variables impacted these relationships, except marital status. Our findings suggest that interventions targeting strengthening the injured persons' sense of belonging and lowering interpersonal conflict may benefit those living with TBI., (© 2011 American Association for Marriage and Family Therapy.)
- Published
- 2012
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25. Therapist-worldview matching: not as important as matching to clients.
- Author
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Blow AJ, Davis SD, and Sprenkle DH
- Subjects
- Humans, Models, Psychological, Professional-Patient Relations, Psychology, Clinical, Family Therapy methods
- Abstract
In this essay, we respond to Simon's article (2012). We discuss our view that therapy works best when therapists can match therapeutic interventions to the worldview of clients. We see this matching to client worldview as rooted in research evidence, and we suggest that therapists can practice authentically and effectively using more than one divergent therapy approach. We conclude the paper by pointing out points of disagreement we have with Simon's use of Davis and Piercy's (Journal of Marital and Family Therapy, 2007a; 33, 298; Journal of Marital and Family Therapy, 2007b, 32, 515) study, a study Simon uses to ground his arguments., (© 2012 American Association for Marriage and Family Therapy.)
- Published
- 2012
- Full Text
- View/download PDF
26. The emotional journey of women experiencing a breast abnormality.
- Author
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Blow AJ, Swiecicki P, Haan P, Osuch JR, Symonds LL, Smith SS, Walsh K, and Boivin MJ
- Subjects
- Adult, Aged, Emotions, Female, Humans, Life Change Events, Michigan, Middle Aged, Quality of Life psychology, Adaptation, Psychological, Breast Neoplasms psychology, Fear psychology
- Abstract
Using grounded theory, a multidisciplinary study team compared the narratives of 30 women who had recently experienced a breast cancer scare. Even though 10 women received a benign diagnosis, all women reported a difficult time prediagnosis, characterized by an array of emotions and contemplation of the meaning of life. Diagnosis separated the two groups with emotional relief dominant for the benign group and intensification of emotions for the cancer group. For those diagnosed with cancer, three factors contributed to arriving at a point of acceptance about the diagnosis and treatment: (a) sustained coping mechanisms; (b) a belief system that shifted the meaning of the cancer experience; and (c) the ability to manage non-cancer-related stressful events. Implications include the need for tailored biopsychosocial treatments that focus on reducing stress, enhancing support systems, reframing beliefs about the illness, and providing the opportunity for the women to talk about their experiences.
- Published
- 2011
- Full Text
- View/download PDF
27. Using pictures to evoke spiritual feelings in breast cancer patients: development of a new paradigm for neuroimaging studies.
- Author
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Symonds LL, Yang L, Mande MM, Mande LA, Blow AJ, Osuch JR, Boivin MB, Giordani B, Haan PS, and Smith SS
- Subjects
- Adult, Aged, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Models, Theoretical, Photic Stimulation, Quality of Life, Surveys and Questionnaires, Breast Neoplasms psychology, Photography, Spirituality
- Abstract
This study was designed to develop and validate a method for enhancing spiritual feelings, particularly in women who have received a diagnosis of breast cancer. The protocol specifically was developed to be used in functional magnetic resonance imaging (fMRI) studies. Eighteen breast cancer survivors rated pictures for their ability to enhance feelings of spirituality, happiness, and sadness. Results indicate that presenting carefully selected pictures with spiritual content (e.g., nature scenes, people engaged in contemplative behaviors) can effectively enhance spiritual feelings among breast cancer survivors. Future fMRI studies will explore the use of the protocol developed in this study for investigating neural activity during spiritual feelings and states.
- Published
- 2011
- Full Text
- View/download PDF
28. National Guard families after combat: mental health, use of mental health services, and perceived treatment barriers.
- Author
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Gorman LA, Blow AJ, Ames BD, and Reed PL
- Subjects
- Adolescent, Adult, Afghan Campaign 2001-, Career Mobility, Female, Health Care Costs, Humans, Iraq War, 2003-2011, Male, Mass Screening, Mental Disorders epidemiology, Middle Aged, Midwestern United States epidemiology, Prevalence, Social Stigma, Community Mental Health Services statistics & numerical data, Mental Disorders prevention & control, Mental Health, Military Personnel psychology, Patient Acceptance of Health Care
- Abstract
Objective: National Guard forces have deployed in large numbers to Iraq and Afghanistan since September 11, 2001. The purpose of this cross-sectional study was to assess mental health symptoms, utilization of mental health services, and perceived barriers to service use among National Guard members and their significant others (including spouses and others with whom they share a committed relationship) from a Midwestern state., Methods: Participants were recruited for the study at military-sponsored reintegration workshops, which took place 45-90 days after service members' return from deployment. A sample of 332 National Guard members and 212 significant others volunteered to complete a survey that assessed mental health symptoms, service utilization, and barriers to treatment., Results: Forty percent of National Guard members and 34% of significant others met the screening criteria for one or more mental health problems. Of those meeting the criteria, 53% reported seeking help of some kind (50% of soldiers; 61% of significant others). Stigma associated with mental health care and concerns about service utilization appearing on military records ranked high as barriers among service members. Concerns about the influence of mental health issues on career advancement were of note. For significant others, barriers included the costs of mental health care, trouble with scheduling appointments, difficulty in getting time off work, and not knowing where to get help., Conclusions: The mental health effects of combat on the soldier and his or her significant other remain a challenge for National Guard families, who often reside in communities that show little understanding of the psychological costs of war. Barriers remain for mental health service utilization.
- Published
- 2011
- Full Text
- View/download PDF
29. Public-academic partnerships: working together to meet the needs of Army National Guard soldiers: an academic-military partnership.
- Author
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Dalack GW, Blow AJ, Valenstein M, Gorman L, Spinner J, Marcus S, Kees M, McDonough S, Greden JF, Ames B, Francisco B, Anderson JR, Bartolacci J, and Lagrou R
- Subjects
- Academic Medical Centers organization & administration, Afghan Campaign 2001-, Hospitals, Veterans organization & administration, Humans, Iraq War, 2003-2011, Mental Disorders etiology, Mental Disorders therapy, Michigan, Mental Health Services organization & administration, Military Medicine organization & administration, Military Personnel psychology, Public-Private Sector Partnerships organization & administration
- Abstract
The conflicts in Afghanistan and Iraq have greatly increased the number of veterans returning home with combat exposure, reintegration issues, and psychiatric symptoms. National Guard soldiers face additional challenges. Unlike active duty soldiers, they do not return to military installations with access to military health services or peers. The authors describe the formation and activities of a partnership among two large state universities in Michigan and the Michigan Army National Guard, established to assess and develop programming to meet the needs of returning soldiers. The process of forming the partnership and the challenges, opportunities, and benefits arising from it are described.
- Published
- 2010
- Full Text
- View/download PDF
30. Covariates of substance-use initiation for Venezuelan youth: using a multilevel approach to guide prevention programs.
- Author
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Cox RB Jr, Blow AJ, Maier KS, and Parra Cardona JR
- Subjects
- Adolescent, Age Factors, Attention, Child, Cross-Sectional Studies, Family Relations, Female, Humans, Internal-External Control, Male, Models, Statistical, Peer Group, Risk Factors, Sex Factors, Social Class, Substance-Related Disorders prevention & control, Surveys and Questionnaires, United States epidemiology, Urban Population, Venezuela epidemiology, Students psychology, Substance-Related Disorders epidemiology
- Abstract
Objective: Illicit drug use in Latin America is on the rise. This study contributes to the literature by examining the extent five factors related to adolescent substance use among U.S. populations covary with age at first use in a sample of Venezuelan inner-city youth., Method: Anonymous self-administered questionnaires on drug involvement and related behaviors were administered to a cross-sectional sample of students, ages 11 to 18, drawn from 14 schools in two school districts in Caracas, Venezuela. A multilevel modeling approach investigated the relationship between age at first drug use reported by 1,514 students and three covariates (family attention, externalizing behavior, and peer drug use) and two control variables (gender and socioeconomic status)., Results: For the Level 1 within-schools covariates, family attention (t = 5.14, 1440 df, p < .001), and externalizing behavior (t = -4.61, 1440 df, p < .001) were significantly related to age at first use, and females initiated use later than did males (t = 2.51, 1440 df,p < .001). Peer drug use and socioeconomic status did not significantly covary with age at first use. At Level 2, the family attention slope varied across schools, chi(2)(13) = 24.14,p = .03. Additionally, mean school-level socioeconomic status (t = -7.22, 13 df, p < .001) explained most of the variance in average age at first use between schools and exerted a much stronger influence on age at first use than did family attention, externalizing behavior, or gender., Conclusions: Factors influencing substance initiation vary from the United States to Venezuela. Specific school cultures are stronger predictors of initiation than more proximal influences.
- Published
- 2010
- Full Text
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31. Parental combat injury and early child development: a conceptual model for differentiating effects of visible and invisible injuries.
- Author
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Gorman LA, Fitzgerald HE, and Blow AJ
- Subjects
- Child, Child, Preschool, Combat Disorders psychology, Humans, Military Personnel psychology, Parents psychology, Psychology, Child, Stress Disorders, Post-Traumatic psychology, Veterans psychology, Warfare, Wounds and Injuries psychology, Child Development, Family psychology, Models, Psychological
- Abstract
The injuries (physical and emotional) sustained by service members during combat influence all members of a family system. This review used a systemic framework to conceptualize the direct and indirect effects of a service member's injury on family functioning, with a specific focus on young children. Using a meta-ethnographic approach to synthesize the health research literature from a variety of disciplines, this review makes relevant linkages to health care professionals working with injured veterans. Studies were included that examined how family functioning (psychological and physical) is impacted by parental illness; parental injury; and posttraumatic stress disorder. The synthesis of literature led to the development of a heuristic model that illustrates both direct and indirect effects of parental injury on family functioning and the development of young children. It further illustrates the contextual factors or moderating variables that buffer detrimental effects and promote family resilience. This model can be a foundation for future research, intervention, and policy.
- Published
- 2010
- Full Text
- View/download PDF
32. Change processes in couple therapy: an intensive case analysis of one couple using a common factors lens.
- Author
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Blow AJ, Morrison NC, Tamaren K, Wright K, Schaafsma M, and Nadaud A
- Subjects
- Adaptation, Psychological, Defense Mechanisms, Education, Graduate, Emotions, Family Conflict psychology, Female, Follow-Up Studies, Humans, Male, Marital Therapy education, Motivation, Poverty psychology, Professional-Patient Relations, Set, Psychology, Marital Therapy methods
- Abstract
The article describes a research study that explored the process of how change occurred for one distressed couple and a specific therapist in a naturalistic setting. Quantitative and qualitative data were collected on the couple at multiple points in the therapy. A research team comprised of five members met regularly to analyze the data and collectively they arrived at a theory of change for the couple posttherapy. Conclusions are made related to how change occurred for the couple with an emphasis on the role of extratherapeutic events, client motivational factors, the therapeutic alliance, hope and expectancy factors, therapist factors, specific techniques and interventions, and other surprise factors that contributed to change.
- Published
- 2009
- Full Text
- View/download PDF
33. Is who delivers the treatment more important than the treatment itself? The role of the therapist in common factors.
- Author
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Blow AJ, Sprenkle DH, and Davis SD
- Subjects
- Humans, Psychotherapy, United States, Couples Therapy, Family Therapy, Professional Role
- Abstract
In this article, we discuss the role of the therapist in change in couple and family therapy. We argue that the therapist is a key change ingredient in most successful therapy. We situate our discussion in the common factors debate and show how both broad and narrow common factor views involve the therapist as a central force. We review the research findings on the role of the therapist, highlight the strengths and weaknesses of this literature, and provide directions for future research. We then use this review as a foundation for our recommendations for theory integration, training, and practice.
- Published
- 2007
- Full Text
- View/download PDF
34. Infidelity in committed relationships II: a substantive review.
- Author
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Blow AJ and Hartnett K
- Subjects
- Culture, Ethnicity statistics & numerical data, Female, Humans, Male, Socioeconomic Factors, Extramarital Relations ethnology, Family Characteristics, Interpersonal Relations
- Abstract
This article, a follow-up on our methodological review of infidelity studies, provides a substantive review of the research findings on infidelity in committed relationships. The aim of this article is to present the most conclusive findings available to both researcher and practitioner on the subject of infidelity. We highlight attitudes toward infidelity; prevalence data; types of infidelity; gender dynamics and infidelity; issues in the primary relationship and their relationship to infidelity; race, culture, and infidelity; education, income, employment, and infidelity; justifications for infidelity; individual issues and their relationship to infidelity; same-sex couples and infidelity; attachment and infidelity; opportunity and infidelity; the aftermath and recovery process from infidelity; and clinical practices.
- Published
- 2005
- Full Text
- View/download PDF
35. Infidelity in committed relationships I: a methodological review.
- Author
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Blow AJ and Hartnett K
- Subjects
- Female, Humans, Male, Extramarital Relations, Interpersonal Relations, Sexual Partners
- Abstract
Infidelity is perhaps the most complex issue encountered by couple therapists. Although clinical literature, opinion, and speculation on this topic are abundant, research literature is sparse. What little available research exists is, in most cases, neither robust nor helpful to the practicing therapist. This article provides, in both narrative and table format, a comprehensive methodological review of the available research literature on infidelity from 1980 to present. Topics addressed in the narrative include the lack of a consensus on the definition of infidelity; design challenges, such as retrospective research, confidentiality, measures, and variables, and sampling issues, such as diversity and randomization. Throughout the article, we offer suggestions for future research.
- Published
- 2005
- Full Text
- View/download PDF
36. Common factors are not islands--they work through models: a response to Sexton, Ridley, and Kleiner.
- Author
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Sprenkle DH and Blow AJ
- Subjects
- Attitude of Health Personnel, Diffusion of Innovation, Humans, Models, Psychological, Outcome Assessment, Health Care, Patient Satisfaction, Research Design, United States, Clinical Competence standards, Family Therapy methods, Family Therapy standards, Marital Therapy methods, Marital Therapy standards, Professional-Patient Relations
- Abstract
In this article, we respond to Sexton, Ridley, and Kleiner (this issue) from three different perspectives. First, we discuss their criticisms as rooted in a portrait of common factors to which we do not subscribe. Second, we discuss points of agreement and partial agreement between our two articles. Finally, we discuss our areas of clear disagreement with their points of view. In these areas of disagreement we put forth the common factors approach as an empirically supported lens; we discuss the influence of investigator allegiance on the specificity conclusion; and we challenge the idea that the common factors lens is simple. In conclusion, we illustrate how common factors work through a credible therapy model using functional family therapy as an example.
- Published
- 2004
- Full Text
- View/download PDF
37. Common factors and our sacred models.
- Author
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Sprenkle DH and Blow AJ
- Subjects
- Attitude of Health Personnel, Diffusion of Innovation, Evidence-Based Medicine methods, Evidence-Based Medicine standards, Humans, Models, Psychological, Outcome Assessment, Health Care, United States, Family Therapy methods, Family Therapy standards, Marital Therapy methods, Marital Therapy standards
- Abstract
In this article we argue that much of what makes one treatment effective is common to other forms of effective treatment--both in psychotherapy generally and in marital and family therapy (MFT) specifically. Yet MFT has largely ignored the research on common factors. In this article we present a moderate view of common factors that, while repudiating the extreme position that there is no difference among treatment models, stresses that there are common factors and mechanisms of change that undergird most forms of successful treatment. These common mechanisms of change should be given more attention in our field, which has tended to emphasize the uniqueness of our sacred models. We delineate some of the major common factors, review the empirical evidence for them, and discuss implications of adapting a common factors informed approach to family therapy.
- Published
- 2004
- Full Text
- View/download PDF
38. Common factors across theories of marriage and family therapy: a modified Delphi study.
- Author
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Blow AJ and Sprenkle DH
- Subjects
- Adult, Aged, Family Therapy methods, Female, Humans, Interviews as Topic, Male, Middle Aged, Models, Psychological, United States, Attitude of Health Personnel, Delphi Technique, Marital Therapy methods
- Abstract
The Delphi methodology was used to explore common factors across theories of marriage and family therapy (MFT). Leading clinicians and researchers from the American Family Therapy Academy and select faculty members from MFT training programs accredited by the Commission on Accreditation for Marriage and Family Therapy Education were asked to achieve consensus regarding common factors. Respondents were asked to report on commonalities across the various MFT theories, as well as what they personally considered to be the core ingredients of change. A final profile of items was created from the responses. Qualitative interviews were conducted with selected panelists to clarify discrepancies as well as to add meaning to the data. Implications for the training and practice of MFTs as well as direction for future research are discussed.
- Published
- 2001
- Full Text
- View/download PDF
39. Acute effects of doxorubicin on human left ventricular systolic and diastolic function.
- Author
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Brown KA, Blow AJ, Weiss RM, and Stewart JA
- Subjects
- Adult, Coronary Circulation drug effects, Diastole, Female, Heart diagnostic imaging, Heart physiology, Humans, Male, Middle Aged, Radionuclide Ventriculography, Stroke Volume drug effects, Systole, Time Factors, Doxorubicin pharmacology, Heart drug effects
- Abstract
Although the long-term cardiotoxic effects of cumulative doses of doxorubicin are well established, the short-term effects on cardiac function are uncertain. Therefore we examined the short-term effects of doxorubicin on left ventricular systolic and diastolic function following a total of 56 doses of doxorubicin in 15 patients with normal resting left ventricular function. Resting radionuclide ventriculography was performed 1 hour before and 4 hours after each dose of doxorubicin. Left ventricular ejection fraction increased significantly from 64 +/- 1% to 67 +/- 1% (p less than 0.001) after doxorubicin. In addition, peak ejection rate (p less than 0.005) and peak filling rate (p less than 0.0005) increased significantly following short-term doxorubicin administration. There was no relationship between either the individual or cumulative dose of doxorubicin and the acute ejection fraction, peak ejection rate, or peak filling rate response. Our data suggest that doxorubicin acutely increases left ventricular systolic and diastolic function.
- Published
- 1989
- Full Text
- View/download PDF
40. Effect of thymosin alpha one on specific antibody response and susceptibility to infection in young and aged mice.
- Author
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Ershler WB, Hebert JC, Blow AJ, Granter SR, and Lynch J
- Subjects
- Aerosols, Animals, Antibody Specificity drug effects, Antigens, Bacterial administration & dosage, Bacterial Vaccines immunology, Immunity, Innate drug effects, Mice, Mice, Inbred C57BL, Pneumococcal Vaccines, Streptococcus pneumoniae immunology, Tetanus Toxoid immunology, Thymalfasin, Thymosin pharmacology, Aging drug effects, Antibodies, Bacterial biosynthesis, Bacterial Infections immunology, Thymosin analogs & derivatives
- Abstract
The antibody response to a variety of antigens has been shown to diminish with age. We investigated the capacity for Thymosin Alpha One (T alpha 1) treatment to augment antibody production in tetanus toxoid (TT) and pneumococcal capsular polysaccharide (PN) inoculated young and old mice. We also measured survival of these immunized mice after aerosol exposure to Streptococcus pneumoniae. As predicted antibody response to TT, but not PN, was significantly reduced in the old animals and T alpha 1 augmented antitetanus antibody in both young and old mice. T alpha 1 did not have an effect on anti pneumococcal antibody production. All mice that had received PN did have an antibody response, yet survival after exposure to the organism was strikingly less in the old animals. Our data support the contention that antibody response to T-dependent antigens (such as tetanus toxoid) falls with aging but can be reconstituted somewhat by thymic factors. Furthermore, for T-independent antigen (such as pneumococcal capsular antigens) the age-related changes are less evident. In the latter situation, the presence of a brisk antibody response after vaccination was not sufficient to prevent pneumonia and death in old animals.
- Published
- 1985
- Full Text
- View/download PDF
41. Experimental tumors and aging: local factors that may account for the observed age advantage in the B16 murine melanoma model.
- Author
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Ershler WB, Gamelli RL, Moore AL, Hacker MP, and Blow AJ
- Subjects
- Animals, Collagen biosynthesis, Male, Mice, Mice, Inbred C57BL, Proline analogs & derivatives, Proline pharmacology, Wound Healing, Aging, Melanoma pathology
- Abstract
In the B16 murine melanoma model tumor growth has been shown to be slower in animals of advanced age. One feature associated with this slower growth has been prominent fibrosis demonstrated in biopsies of the tumor in older animals. We have performed experiments to examine the fibrotic response in young and old mice. In non-tumor bearing animals the capacity to regain skin strength after surgical laceration and healing by primary intention was greater in old mice. Histologic preparations suggested a more prominent fibrosis at the wound site. The animals who were injected subcutaneously with B16 melanoma and treated with L 3,4-dehydroproline (an inhibitor of collagen synthesis) local tumor growth was significantly enhanced only for the old animals. Although this inhibition of collagen synthesis produced a differential growth enhancement, there remained a significant difference in tumor volume between young and old animals. We conclude that fibrogenesis is an important host defense for containing local tumor growth and that this mechanism is preserved if not enhanced in mice of advanced age. Nevertheless other factors are needed to account completely for the observed age-advantage in the B16 melanoma model.
- Published
- 1984
- Full Text
- View/download PDF
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