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This book illustrates recent advances in developing sensitive and selective electrochemical biosensors for their whole blood application. Known to be a cutting-edge and fast-growing technology, electrochemical biosensors demonstrate their potential in laboratories, industries, and healthcare to achieve specific and direct target detection in complex media, and have become an emerging technology for guiding personalized medicine. The book first demonstrates methods and models to cover the detection of a variety of target molecules in whole blood, including ions, small molecules, nucleic acids, proteins, cells, etc. Then, it provides comments on various detection strategies employed to improve sensors'sensitivity, specificity, selectivity, and reproducibility as well as presenting the laws and principles. In addition, it summarizes achievements and challenges from recent years. Finally, it provides future perspectives and opportunities in electrochemical biosensors including point of care detection, molecular diagnostics and the integration of this sensor platform with multidisciplinary technologies, towards the ultimate goal of personalized medicine. The book integrates abundant viewpoints from multiple sciences and is helpful and valuable to a wide readership in the various fields of biochemistry, biophysics, bioengineering, and pharmaceutics.

This book provides a comprehensive summary of all routine blood tests used in modern primary and secondary health care by explaining the rationale for, and value of, each individual blood test. It provides a valuable guide for health care providers in a time when multidisciplinary roles are being embraced. This book will allow health professionals to be fully affective in assessing the results of blood tests and explaining these results to patients.

Phlebotomy Essentials, Enhanced Seventh Edition provides accurate, up-to-date, and practical information and instruction in phlebotomy procedures and techniques, along with a comprehensive background in phlebotomy theory and principles.

This book was originally written after feedback suggested that storytelling was very helpful to students and practitioners wanting to remember blood tests and their implications. Each section, where appropriate, therefore contains a ‘story', as well as an overview of the relevant anatomy, physiology and biochemistry. This revised, updated edition continues to use storytelling to aid understanding, and introduces a unique 10-point system to help explain blood results. The use of storytelling has also been significantly improved and refined, following several years of feedback on the first edition. Less formal than a biochemistry textbook and containing more narrative than an online protocol, Blood Results in Clinical Practice provides an excellent, accessible introduction to blood tests and what they mean. It also enables advanced practitioners to reflect on and improve their practice; and includes new and updated sections of relevance to physiotherapists, paramedics, pharmacists and advanced nurse practitioners. Finally, it provides a resource for patients and their relatives who may be keen to know more about the meaning and function of particular blood tests.

For more than 65 years, this best-selling text by Drs. Barbara J. Bain, Imelda Bates, and Mike A. Laffan has been the worldwide standard in laboratory haematology. The 12th Edition of Dacie and Lewis Practical Haematology continues the tradition of excellence with thorough coverage of all of the techniques used in the investigation of patients with blood disorders, including the latest technologies as well as traditional manual methods of measurement. You'll find expert discussions of the principles of each test, possible causes of error, and the interpretation and clinical significance of the findings. A unique section on haematology in under-resourced laboratories. Ideal as a laboratory reference or as a comprehensive exam study tool. diagnosis, molecular testing, blood transfusion- and much more. Complete coverage of the latest advances in the field. An expanded section on coagulation now covers testing for new anticoagulants and includes clinical applications of the tests.

Featuring hundreds of full-color photomicrographs, Rodak's Hematology: Clinical Principles and Applications, 5th Edition prepares you for a job in the clinical lab by exploring the essential aspects of hematology. It shows how to accurately identify cells, simplifies hemostasis and thrombosis concepts, and covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins. This text also makes it easy to understand complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics. Clinical lab experts Elaine Keohane, Larry Smith, and Jeanine Walenga also cover key topics such as working in a hematology lab, the parts and functions of the cell, and laboratory testing of blood cells and body fluid cells. Instructions for lab procedures include sources of possible errors along with comments. Case studies in each chapter provide opportunities to apply hematology concepts to real-life scenarios. Hematology instruments are described, compared, and contrasted. UPDATED, full-color illustrations make it easier to visualize hematology concepts and show what you'll encounter in the lab, with images appearing near their mentions in the text so you don't have to flip pages back and forth. Hematology/hemostasis reference ranges are listed on the inside front and back covers for quick reference. A bulleted summary makes it easy to review the important points in every chapter. Learning objectives begin each chapter and indicate what you should achieve, with review questions appearing at the end. A glossary of key terms makes it easy to find and learn definitions. NEW coverage of hematogones in the chapter on pediatric and geriatric hematology helps you identify these cells, a skill that is useful in diagnosing some pediatric leukemias. UPDATED chapter on molecular diagnostics covers new technology and techniques used in the lab.

La Hematología es un área de la Medicina que trata los pacientes con trastornos hematológicos de manera benigna y maligna, que mediante apoyo de medios diagnósticos, como la citometría de flujo, el extendido periférico, el hemograma automatizado, mielograma permiten un diagnóstico acertado para beneficio del paciente y apoyo para el médico. Es por eso que el Laboratorio de Hematología ha diseñado un modelo de texto-atlas para los estudiantes de Salud, en pre y posgrado, en las diferentes especialidades, Medicina, Bacteriología y Laboratorio Clínico, Odontología, entre otras. Este atlas tiene la finalidad de ilustrar, mediante fotografías tomadas directamente en el Laboratorio de Hematología, el aspecto microscópico de las células normales y aquellas asociadas a diversos trastornos hematológicos, tanto en el aspirado de médula ósea como de sangre periférica; además sirve de apoyo complementario, por su texto tipo monografía, para que el lector lo use como libro de consulta. Es un atlas dinámico, sencillo y aplicado a la Hematología benigna, desde simples anemias; hasta la patología maligna, con sus leucemias y otras alteraciones hematológicas.

The preanalytical phase is an important component of Laboratory medicine and errors arising in this phase affect the validity of laboratory results. In this book physicians and clinical staff have access to valuable information about the current preanalytical variables and factors (patient preparation, sample collection, handling and processing before analysis).

Clinical laboratory directors and staff working with blood samples will benefit from the essential information in this hematology focused publication in Clinics in Laboratory Medicine. Leading a field of expert authors are two renown physicians in the field - Dr Carlo Brugnara and Dr Alexander Kratz. They present topics such as White Blood Cell Counts: Reference Methodology; Integration of Automated Heme and Bone Marrow Analysis; Red Cell Dynamics; Red Cell Diagnosis other than Anemia; Laboratory and Genetic Assessment of Iron Deficiency in Blood Donors; Body Fluid Cell Counting; Platelets: The Few, the Young, and the Active; Reticulocytes; Quality Control of Automated Cell Counters; Digital Image Analysis of Blood Cells; Blood Cell Counters in Urgent Care Settings; Novel Parameters in Blood Cell Counters; and the Development and Future of Automated Blood Cell Counters.

It's All In The Blood…What Microscopy Can Do For You. This ebook is power packed full of information about discovering what is going on in your blood. The excitement of getting to the root causes of what is truly ailing you. This book is a must have for everyone.

This book was written after feedback suggested that stories and analogies were very helpful to students wanting to remember blood tests and their implications. For this reason each section, where appropriate, contains an analogy, in addition to an overview of the relevant anatomy, physiology and biochemistry. The book links tests and conditions, and gives strategies for clinical practice using simple language. It will be useful as a supplementary text for those studying nursing, healthcare and medicine. It will also provide a quick-reference handbook for working healthcare professionals. Finally, it will provide a resource for patients and their relatives who may be keen to know more about the meaning and function of a particular blood test.

The idea for this book arose from an integrated Iecture course on the biochemistry of blood given to medical students in the second year of their pre-clinical studies. However, the material in that course has been expanded and it is intended that the book provide both the medical and non-medical reader with a concise and up-to-date account of the status of knowiedge of the biochemistry of blood. A glance at the chapter titles shows how wide a field this covers, including many of the growth areas in biochemistry. It is assumed that readers of the book will have a basic knowiedge of biochemistry. A functional approach is, adopted, and whenever possible the material is organised in terms of biochemical functions, although there are separate chapters on the white cell and the red cello Because of the clinical importance of analysing blood components and assaying enzymes in the diagnosis of disease, chapters are included on the separation, preparation and measurement of blood components.

Now in its third edition, this essential handbook for nurses and allied health professionals gives clear, simple explanations of blood results, focusing on routinely requested investigations. There have been many changes since the second edition - from alterations in units (such as g/L for haemoglobin, rather than g/dL) to the merging of haematology with biochemistry, blood transfusion and immunology to form blood science. Accordingly, in this new edition there are more details of immunology, immunological diseases, and the blood tests involved. These changes reflect the new roles which nurses.

Expertly edited and endorsed by the International Society for Laboratory Hematology, this is the newest international textbook on all aspects of laboratory hematology. Covering both traditional and cutting-edge hematology laboratory technology this book emphasizes international recommendations for testing practices. Illustrative case studies on how technology can be used in patient diagnosis are included. Laboratory Hematology Practice is an invaluable resource for all those working in the field.

Featuring hundreds of full-color photomicrographs, Hematology: Clinical Principles and Applications prepares you for a job in the clinical lab by exploring the essential aspects of hematology. It shows how to accurately identify cells, simplifies hemostasis and thrombosis concepts, and covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins. This book also makes it easy to understand complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics. Well-known authors Bernadette Rodak, George Fritsma, and Elaine Keohane cover everything from working in a hematology lab to the parts and functions of the cell to laboratory testing of blood cells and body fluid cells.Full-color illustrations make it easier to visualize complex concepts and show what you'll encounter in the lab.Learning objectives begin each chapter, and review questions appear at the end.Instructions for lab procedures include sources of possible errors along with comments.Case studies provide opportunities to apply hematology concepts to real-life scenarios.Hematology instruments are described, compared, and contrasted.Coverage of hemostasis and thrombosis includes the development and function of platelets, the newest theories of normal coagulation, and clear discussions of platelet abnormalities and disorders of coagulation.A bulleted summary of important content appears at the end of every chapter.A glossary of key terms makes it easy to find and learn definitions.Hematology/hemostasis reference ranges are listed on the inside front and back covers for quick reference.Respected editors Bernadette Rodak, George Fritsma, and Elaine Keohane are well known in the hematology/clinical laboratory science world.Student resources on the companion Evolve website include the glossary, weblinks, and content updates. New content is added on basic cell biology and etiology of leukocyte neoplasias.Updated Molecular Diagnostics chapter keeps you current on techniques being used in the lab.Simplified hemostasis material ensures that you can understand this complex and important subject.Coverage of morphologic alteration of monocytes/macrophages is condensed into a table, as the disorders in this grouping are more of a biochemical nature with minimal hematologic evidence.

Microfabrication technology has stimulated a plurality of lab-on-a-chip research and development efforts aimed at enabling biomedical researchers and health care practitioners to manipulate and analyze complex biological fluids at the nano and microliter scale. On-chip pretreatment of whole blood is one of the hottest topics in lab-on-a-chip research since whole blood has been regarded as the most important clinical sample. Various microfluidic chips for blood sample pretreatment, such as plasma isolation, cells separation, cells lysis, gene or protein purification, etc., are described in this e-book. These microchips are designed and fabricated by MEMS technology. Original clinical samples, such as whole blood, which could be directly pre-treated on the microfluidic chips, can increase diagnostic capacity significantly by enabling rapid, point-of-care chemical analysis requiring only nanoliter sample and reagent volumes, thereby reducing cost and turn-around time. This e-book is a valuable reference for readers interested in this specific clinical application of advanced MEMS technology.

L'immunohématologie est une discipline de la biologie médicale qui étudie les antigènes de groupes sanguins érythrocytaires et les anticorps dont ils peuvent être la cible. Cent dix ans après la découverte par Karl Landsteiner des premiers antigènes de groupes sanguins et de la notion d'allo-réactivité, les connaissances dans le domaine ont considérablement progressé. De façon corrélée, les techniques de mise en évidence et de caractérisation des antigènes et des anticorps anti-érythrocytaires, ainsi que l'évaluation de leur impact clinique éventuel, ont également beaucoup évolué. L'un des objectifs premiers de cet ouvrage est de faire le point sur les différentes analyses immunohématologiques existantes. Il en décrit les objectifs, les contraintes de réalisation, les exploitations possibles quant à leurs résultats, mais aussi leurs limites techniques et d'interprétation. De nombreuses'solutions techniques'sont proposées, dont certaines sont rassemblées dans un ensemble de fiches présentées à la fin de l'ouvrage. Elles permettront aux biologistes et techniciens de résoudre la plupart des problèmes techniques ou biologiques rencontrés. Au-delà de leur intérêt théorique dans le domaine de l'anthropologie génétique (non abordé dans l'ouvrage), c'est dans des circonstances cliniques bien précises que les groupes sanguins jouent tout leur rôle, notamment : transfusion sanguine, grossesse,... Ces différents domaines d'utilisation des résultats d'immunohématologie sont traités dans la deuxième partie de l'ouvrage. Enfin, dans la dernière partie du livre, les auteurs envisagent les technologies du futur en immunohématologie.

The diagnosis and monitoring of hematological malignancies is complex and requires a systematic approach. Morphology, cell phenotyping, cytogenetics and molecular genetics are essential, and the results must be integrated. Diagnostic Techniques in Hematological Malignancies details the principles and applications of each of these test types in the diagnosis of hematological malignancies in blood and bone marrow. The first section describes the test modalities – including methodological principles, data interpretation and limitations – and is illustrated by clinical examples. The second section focuses on the clinical entities, detailing the most appropriate tests for diagnosis, staging and monitoring of different hematological malignancies and includes test utilization to identify prognostic markers and potential therapeutic targets. With contributions from multiple international experts, this illustrated book is an essential resource for qualified and trainee hematologists, oncologists, and pathologists. It's a practical and useful guide, providing a rational and structured approach to the laboratory assessment of hematological malignancies.