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230 results on '"Blondeau, B."'

19. Strained Silicon on Insulator wafers made by the Smart Cut™ technology

Author

Ghyselen, B., Bogumilowicz, Y., Aulnette, C., Abbadie, A., Osternaud, B., Besson, P., Daval, N., Andrieu, F., Cayrefourq, I., Moriceau, H., Ernst, T., Tiberj, A., Rayssac, O., Blondeau, B., Mazure, C., Lagahe-Blanchard, C., Pocas, S., Cartier, A.-M., Hartmann, J.-M., Leduc, P., Nardo, C. Di, Lugand, J.-F., Fournel, F., Semeria, M.-N., Kernevez, N., Campidelli, Y., Kermarrec, O., Morand, Y., Rivoire, M., Bensahel, D., Paillard, V., Vincent, L., Claverie, A., and Boucaud, P.

Published
2003
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21. [Quantification and monitoring of vascular resistance in the lower limbs by the Doppler method (animal model)]

Author

Arbeille, P, Berson, M, Blondeau, B, Durand, A, Bodard, S, Locatelli, A, and Fox, G. E

Subjects
Exobiology
Abstract

The object of this study was to define and validate a non-invasive method of evaluation and monitoring of vascular resistances in the leg. Blood flow velocity was measured by Doppler ultrasound in an animal model (ewe) with similar blood flow characteristics in the lower limb as man and allowing access to the required invasive measurements for validation of the method (pressure and flow). Vascular resistances distal to the measuring point (femoral, for example) were assessed using the resistance index R = D/S, S being the peak systolic deflection and D that of diastolic reflux of the Doppler spectral analysis of flow in the femoral artery. The values and variations of this resistance index were compared with the vascular resistances calculated from measurements of pressure and flow at the point of Doppler sampling and expressed in mmHg/ml/min. Femoral flow was measured by Doppler ultrasound (Doppler-echo), and mean pressure by an arterial catheter introduced into the abdominal aorta. Compression of the lower limb veins induced a venous return resulting in a reduction of cardiac output and femoral flow. During compression, femoral flow decreased by an average of 29% (p < 0.001) although mean pressure and heart rate did not change significantly. The femoral resistance index (Rf) increased by an average of 37.5% (p < 0.01) and vascular resistances increased by 45.9% (p < 0.01). Injection of 1 mg adrenaline induced peripheral vasoconstriction with an increase in blood pressure and a decrease in heart rate and femoral flow.(ABSTRACT TRUNCATED AT 250 WORDS).

Published
1995

24. Glucocorticoids impair fetal [Beta]-cell development in rats

Author

BLONDEAU, B., LESAGE, J., CZERNICHOW, P., DUPOUY, J. P., and BREANT, B.

Subjects
Corticosteroids -- Physiological aspects, Rats -- Development, Glucose -- Physiological aspects, Fetus -- Growth retardation, Malnutrition -- Physiological aspects, Biological sciences
Abstract

In rats, poor fetal growth due to maternal food restriction during pregnancy is associated with decreased [Beta]-cell mass at birth and glucose intolerance in adulthood. Overexposure to glucocorticoids in utero can induce intrauterine growth retardation in humans and animals and subsequent glucose intolerance in rodents. The aims of this study were to investigate whether glucocorticoid overexposure mediates the effect of undernutrition on [Beta]-cell mass and to study their potential role in normally nourished rats. Undernutrition significantly increased maternal and fetal corticosterone levels. Twenty-one-day-old fetuses with undernutrition showed growth retardation and decreased pancreatic insulin content; adrenalectomy and subcutaneous corticosterone implants in their dams prevented the maternal corticosterone increase and restored fetal [Beta]-cell mass. In fetuses with normal nutrition, fetal corticosterone levels were negatively correlated to fetal weight and insulin content; fetal [Beta]-cell mass increased from 355 [+ or -] 48 [micro]g in sham to 516 [+ or -] 160 [micro]g after maternal adrenalectomy; inhibition of steroid production by metyrapone induced a further increase to 757 [+ or -] 125 [micro]g. Our data support the new concept of a negative role of glucocorticoids in fetal [Beta]-cell development. undernutrition; pancreatic [Beta]-cell; morphometry; fetal environment

Published
2001

25. NOV/CCN3 : une adipokine impliquée dans la résistance à l’insuline et la dépense énergétique

Author

Fève, B., primary, Garcia, M., additional, Do, T.-T.-H., additional, Antoine, B., additional, Moldes, M., additional, Dorothée, G., additional, Kazakian, C., additional, Auclair, M., additional, Buyse, M., additional, Ledent, T., additional, Marchal, P.-O., additional, Fesatidou, M., additional, Besseiche, A., additional, Koseki, H., additional, Hiraoka, S., additional, Chadjichristos, C., additional, Blondeau, B., additional, Denis, R.-G., additional, Luquet, S., additional, and Martinerie, C., additional

Published
2016
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29. Regulation of mass and function of beta cells by glucocorticoids: implication of serotonin

Author

Riveline, J. P., Massourides, E., Singh-Estivalet, A., Valtat, B., Armanet, M., Callebert, J., Bailly, A., Benecke, A., Tronche, F., Gautier, J. F., Breant, B., Blondeau, B., Expression des Gènes et comportement adaptatifs = Molecular Genetics, Neurophysiology and Behavior (NPS-15), Neuroscience Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neurosciences Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2012

35. O16 Le récepteur nucléaire HNF-4 gamma est un acteur de l’homéostasie glucidique : un rôle critique pour le lignage cellulaire entéroendocrine

Author

Ribeiro, A., primary, Baraille, F., additional, Carrière, V., additional, Osinski, C., additional, Benkouhi, A., additional, Gardin, K., additional, Guillemin, G., additional, Blondeau, B., additional, Serradas, P., additional, Rousset, M., additional, Lacasa, M., additional, and Cardot, P., additional

Published
2014
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40. Different mechanisms operating during different critical time-windows reduce rat fetal beta cell mass due to a maternal low-protein or low-energy diet.

Author

UCL - SC/BIOL - Département de biologie, Dumortier, O, Blondeau, B, Duvillié, B, Reusens, Brigitte, Bréant, B, Remacle, Claude, UCL - SC/BIOL - Département de biologie, Dumortier, O, Blondeau, B, Duvillié, B, Reusens, Brigitte, Bréant, B, and Remacle, Claude

Abstract

AIMS/HYPOTHESIS: Adverse events during intra-uterine life may programme organ growth and favour disease later in life. In animals, protein or energy restriction during gestation alters the development of the endocrine pancreas, even though the duration of malnutrition is different. Here, we evaluate the specific effects of both diets during different periods of gestation and the mechanisms underlying the decreased beta cell mass. METHODS: Pregnant Wistar rats were fed either a low-protein or a low-energy diet during the last week of gestation or throughout gestation. Fetuses and their pancreases were analysed at days 15 and 21 of gestation. RESULTS: The low-energy diet reduced the beta cell mass from 21-day-old fetuses by 33 or 56% when administered during the last week or throughout gestation, respectively. Fetal corticosterone levels were increased. At 15 days of fetal age, the number of cells producing neurogenin 3 (NEUROG3) or pancreatic and duodenal homeobox gene 1 (PDX-1) was reduced. Neither islet vascularisation nor beta cell proliferation was affected. The low-protein diet, in contrast, was more efficient in decreasing the fetal beta cell mass when given during the last week of gestation (-53%) rather than throughout gestation (-33%). Beta cell proliferation was decreased by 50% by the low-protein diet, independently of its duration, and islet vascularisation was reduced. This diet did not affect NEUROG3- or PDX-1-positive cell numbers. CONCLUSION/INTERPRETATION: Although both diets reduced the fetal beta cell mass, the cellular mechanisms and the sensitivity windows were different. Early alteration of neogenesis due to elevated corticosterone levels is likely to be responsible for the decreased beta cell mass in low-energy fetuses, whereas impaired beta cell proliferation and islet vascularisation at later stages are implicated in low-protein fetuses.

Published
2007

44. Quantification et monitorage des résistances vasculaires du membre inférieur. Par méthode Doppler (modèle animal)

Author

Arbeille, P., Berson, M., Blondeau, B., Durand, A., Bodard, S., Locatelli, Aude, Unité de recherche Physiologie de la reproduction des mammifères domestiques, Nouzilly, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
1995

50. O62 Le diabète de type 2 cétonurique est associé à l’infection par l’herpès virus humain de type 8 (HHV-8) chez des patients originaires d’Afrique sub-Saharienne

Author

Sobngwi, E., primary, Choukem, S.P., additional, Agbalika, F., additional, Blondeau, B., additional, Fetita, L.S., additional, Lebbé, C., additional, Cattan, P., additional, Foufelle, F., additional, Ferré, P., additional, Vexiau, P., additional, Calvo, F., additional, and Gautier, J.F., additional

Published
2008
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