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47 results on '"Blokhuis, T.J."'

7. Decreasing incidence of complex regional pain syndrome in the Netherlands: a retrospective multicenter study

Author

Groenveld, T.D., Boersma, E.Z., Blokhuis, T.J., Bloemers, F.W., Frolke, J.P., Groenveld, T.D., Boersma, E.Z., Blokhuis, T.J., Bloemers, F.W., and Frolke, J.P.

Abstract

Item does not contain fulltext, BACKGROUND: Complex regional pain syndrome type I (CRPS) is a symptom-based diagnosis of which the reported incidence varies widely. In daily practice, there appears to be a decrease in incidence of CRPS after a distal radius fracture and in general. QUESTIONS/PURPOSES: The aim of this study was to assess the trend in the incidence of CRPS after a distal radius fracture and in general in the Netherlands from 2014 to 2018. METHODS: The incidence of CRPS after a distal radius fracture was calculated by dividing the number of confirmed cases of CRPS after distal radius fracture by the total number of patients diagnosed with a distal radius fracture. Medical records of these patients were reviewed. Hospital-based data were used to establish a trend in incidence of CRPS in general. A Dutch national database was used to measure the trend in the incidence of CRPS in the Netherlands by calculating annual incidence rates: the number of new CRPS cases, collected from the national database, divided by the Dutch mid-year population. RESULTS: The incidence of CRPS after distal radius fracture over the whole study period was 0.36%. Hospital data showed an absolute decrease in CRPS cases from 520 in 2014 to 223 in 2018. National data confirmed this with a decrease in annual incidence from 23.2 (95% CI: 22.5-23.9) per 100,000 person years in 2014 to 16.1 (95% CI: 15.5-16.7) per 100,000 person years in 2018. CONCLUSION: A decreasing trend of CRPS is shown in this study. We hypothesize this to be the result of the changing approach towards CRPS and fracture management, with more focus on prevention and the psychological aspects of disproportionate posttraumatic pain. LEVEL OF EVIDENCE: level 3 (retrospective cohort study).

Published
2022

8. Muscle Analyzer System: Exploring Correlation Between Novel Microwave Resonator and Ultrasound-based Tissue Information in the Thigh

Author

Mattsson, V., Perez, M.D., Ackermans, L.L.G.C., Vesseur, M.A.M., Bels, J.L.M., van de Poll, M.C.G., Mandal, B., Sanchez-Gonzalez, P., Seiffert, A.P., Gomez, E.J., Meaney, P., Ten Bosch, J.A., Blokhuis, T.J., Augustine, R., Mattsson, V., Perez, M.D., Ackermans, L.L.G.C., Vesseur, M.A.M., Bels, J.L.M., van de Poll, M.C.G., Mandal, B., Sanchez-Gonzalez, P., Seiffert, A.P., Gomez, E.J., Meaney, P., Ten Bosch, J.A., Blokhuis, T.J., and Augustine, R.

Abstract

A microwave sensor to safely measure quality of muscle tissue for diagnosis and screening of diseases and medical conditions characterized by fat infiltration in muscle is presented. Fat infiltration in muscle may be seen by a lower dielectric constant of muscle at microwave frequencies corresponding to the large contrast between fat and muscle tissues. A planar resonator based on a bandstop filter and optimized to noninvasively interrogate muscle in the thigh on tissue quality is proposed. Currently, a study based on clinical trials is carried out, and, here, we present a preliminary correlation between skin and fat thicknesses and rectus femoris cross sectional area (CSA) measured with ultrasound and the proposed sensor's resonance frequency. CST simulations based on the ultrasound information guide the analysis. We see that although there are signs of a potential correlation between CSA and resonance, skin and fat variability is still an issue to overcome.

Published
2022

13. Contributor contact details

Author

Mallick, K.K., primary, Sprio, S., additional, Sandri, M., additional, Iafisco, M., additional, Ruffini, A., additional, Minardi, S., additional, Tampieri, A., additional, Bhattacharya, P., additional, van Lenthe, G.H., additional, Hunziker, E.B., additional, Blokhuis, T.J., additional, Guarino, V., additional, Raucci, M.G., additional, Ronca, A., additional, Cirillo, V., additional, Ambrosio, L., additional, Mallick, K.K., additional, Winnett, J., additional, Bansiddhi, A., additional, Dunand, D.C., additional, Wang, G.C., additional, Lu, Z.F., additional, Zreiqat, H., additional, Bahney, C.S., additional, Marcucio, R.S., additional, Venkatesan, J., additional, Kim, S.K., additional, Grøndahl, L., additional, Goonasekera, C.S., additional, Jack, K.S., additional, Clarke, S.A., additional, and Walsh, P., additional

Published
2014
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18. Vital Signs Monitoring with Wearable Sensors in High-risk Surgical Patients: A Clinical Validation Study

Author

Breteler, M.J.M., KleinJan, E.J., Dohmen, D.A.J., Leenen, L.P.H., van Hillegersberg, R., Ruurda, J.P., van Loon, K., Blokhuis, T.J., Kalkman, C.J., Surgery, MUMC+: MA Heelkunde (9), and RS: NUTRIM - R3 - Respiratory & Age-related Health

Subjects
accuracy, SYSTEMS, AGREEMENT, MORTALITY, afferent limb, RAPID RESPONSE TEAMS, EARLY RECOGNITION, failure, staff, ANTECEDENTS
Abstract

Background:Vital signs are usually recorded once every 8 h in patients at the hospital ward. Early signs of deterioration may therefore be missed. Wireless sensors have been developed that may capture patient deterioration earlier. The objective of this study was to determine whether two wearable patch sensors (SensiumVitals [Sensium Healthcare Ltd., United Kingdom] and HealthPatch [VitalConnect, USA]), a bed-based system (EarlySense [EarlySense Ltd., Israel]), and a patient-worn monitor (Masimo Radius-7 [Masimo Corporation, USA]) can reliably measure heart rate (HR) and respiratory rate (RR) continuously in patients recovering from major surgery.Methods:In an observational method comparison study, HR and RR of high-risk surgical patients admitted to a step-down unit were simultaneously recorded with the devices under test and compared with an intensive care unit-grade monitoring system (XPREZZON [Spacelabs Healthcare, USA]) until transition to the ward. Outcome measures were 95% limits of agreement and bias. Clarke Error Grid analysis was performed to assess the ability to assist with correct treatment decisions. In addition, data loss and duration of data gaps were analyzed.Results:Twenty-five high-risk surgical patients were included. More than 700 h of data were available for analysis. For HR, bias and limits of agreement were 1.0 (-6.3, 8.4), 1.3 (-0.5, 3.3), -1.4 (-5.1, 2.3), and -0.4 (-4.0, 3.1) for SensiumVitals, HealthPatch, EarlySense, and Masimo, respectively. For RR, these values were -0.8 (-7.4, 5.6), 0.4 (-3.9, 4.7), and 0.2 (-4.7, 4.4) respectively. HealthPatch overestimated RR, with a bias of 4.4 (limits: -4.4 to 13.3) breaths/minute. Data loss from wireless transmission varied from 13% (83 of 633 h) to 34% (122 of 360 h) for RR and 6% (47 of 727 h) to 27% (182 of 664 h) for HR.Conclusions:All sensors were highly accurate for HR. For RR, the EarlySense, SensiumVitals sensor, and Masimo Radius-7 were reasonably accurate for RR. The accuracy for RR of the HealthPatch sensor was outside acceptable limits. Trend monitoring with wearable sensors could be valuable to timely detect patient deterioration.

Published
2020

19. The Value of Intraoperative 3-Dimensional Fluoroscopy in the Treatment of Distal Radius Fractures: A Randomized Clinical Trial

Author

Selles, C.A., primary, Beerekamp, M.S.H., additional, Leenhouts, P.A., additional, Segers, M.J.M., additional, Goslings, J.C., additional, Schep, N.W.L., additional, de Muinck Keizer, R.J.O., additional, Ubbink, D.T., additional, Blokhuis, T.J., additional, Kloen, P., additional, van den Berg, R., additional, van Dijkman, B.A., additional, Luitse, J.S.K., additional, Maas, M., additional, Peters, R.W., additional, Twigt, B., additional, and Winkelhagen, J., additional

Published
2020
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20. Factors associated with health-related quality of life, hip function, and health utility after operative management of femoral neck fractures

Author

Sprague, S., Bhandari, M., Heetveld, M.J., Liew, S., Scott, T., Bzovsky, S., Heels-Ansdell, D., Zhou, Q., Kampen, A. van, Biert, J., Vugt, A.B. van, Edwards, M.J.R., Blokhuis, T.J., Frolke, J.P.M., Geeraedts, L.M.G., Gardeniers, J.W.M., Tan, E.C.T.H., Poelhekke, L.M.S.J., Waal Malefijt, M.C. de, Schreurs, B.W., Swiontkowski, M., and Schemitsch, E.H.

Subjects
Male, medicine.medical_specialty, Health utility, Femoral Neck Fractures, Disability Evaluation, Fracture Fixation, Internal, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Medicine and Health Sciences, medicine, Humans, Orthopedics and Sports Medicine, In patient, 030212 general & internal medicine, Aged, Pain Measurement, Femoral neck, Aged, 80 and over, Health related quality of life, 030222 orthopedics, Hip fracture, business.industry, Middle Aged, Prognosis, medicine.disease, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Treatment Outcome, medicine.anatomical_structure, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Quality of Life, Physical therapy, Female, Surgery, business
Abstract

Aims The primary aim of this prognostic study was to identify baseline factors associated with physical health-related quality of life (HRQL) in patients after a femoral neck fracture. The secondary aims were to identify baseline factors associated with mental HRQL, hip function, and health utility. Patients and Methods Patients who were enrolled in the Fixation using Alternative Implants for the Treatment of Hip Fractures (FAITH) trial completed the 12-item Short Form Health Survey (SF-12), Western Ontario and McMaster Universities Arthritis Index, and EuroQol 5-Dimension at regular intervals for 24 months. We conducted multilevel mixed models to identify factors potentially associated with HRQL. Results The following were associated with lower physical HRQL: older age (-1.42 for every ten-year increase, 95% confidence interval (CI) -2.17 to -0.67, p Conclusion We identified several baseline factors associated with lower HRQL, hip function, and utility after a femoral neck fracture. These findings may be used by clinicians to inform treatment and outcomes. Cite this article: Bone Joint J 2018;100-B:361–9.

Published
2018

23. Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Author

Sprague, S. (Sheila), Schemitsch, E.H. (Emil H.), Swiontkowski, M.F. (Marc ), Della Rocca, G.J. (Gregory J.), Jeray, K.J. (Kyle J.), Liew, S. (Susan), Slobogean, G.P. (Gerard P.), Bzovsky, S. (Sofia), Heels-Ansdell, D. (Diane), Zhou, Q. (Qi), Bhandari, M. (Mohit), Sprag, S. (Sheila), Devereaux, P.J., Guyatt, G.H. (Gordon), Heetveld, M.J. (Martin J.), Richardson, M. (Martin), Thabane, L. (Lehana), Tornetta III, P. (Paul), Walter, S.D. (Stephen D.), McKay, P. (Paula), Scott, T. (Taryn), Garibaldi, A. (Alisha), Viveiros, H. (Helena), Swinton, M. (Marilyn), Gichuru, M. (Mark), Buckingham, L. (Lisa), Duraikannan, A. (Aravin), Maddock, D. (Deborah), Simunovic, N. (Nicole), Agel, J. (Julie), Lieshout, E.M.M. (Esther) van, Zielinski, S.M. (Stephanie), Rangan, A. (Amar), Hanusch, B.C. (Birgit C.), Kottam, L. (Lucksy), Clarkson, R. (Rachel), Haverlag, R. (Robert), McCormack, R. (Robert), Apostle, K. (Kelly), Boyer, D. (Dory), Moola, F. (Farhad), Perey, B. (Bertrand), Stone, T. (Trevor), Viskontas, D. (Darius), Lemke, H.M. (H. Michael), Zomar, M. (Mauri), Moon, K. (Karyn), Moon, R. (Raely), Oatt, A. (Amber), Buckley, R.E. (Richard E.), Duffy, P. (Paul), Korley, R. (Robert), Puloski, S. (Shannon), Powell, J. (James), Johnston, K. (Kelly), Carcary, K. (Kimberly), Lorenzo, M. (Melissa), McKercher, R. (Ross), Sanders, D. (David), MacLeod, M. (Mark), Lawendy, A.-R. (Abdel-Rahman), Tieszer, C. (Christina), Stephen, D. (David), Kreder, H. (Hans), Jenkinson, R. (Richard), Nousiainen, M. (Markku), Axelrod, T. (Terry), Murnaghan, J. (John), Nam, D. (Diane), Wadey, V. (Veronica), Yee, A. (Albert), Milner, K. (Katrine), Kunz, M. (Monica), Ghent, W. (Wesley), McKee, M.D. (Michael D.), Hall, J.A. (Jeremy A.), Nauth, A. (Aaron), Ahn, H. (Henry), Whelan, D.B. (Daniel B.), Vicente, M.R. (Milena R.), Wild, L.M. (Lisa M.), Khan, R.M. (Ryan M.), Hidy, J.T. (Jennifer T.), Coles, C. (Chad), Leighton, R. (Ross), Biddulph, M. (Michael), Johnston, D. (David), Glazebrook, M. (Mark), Alexander, D. (David), Coady, C. (Catherine), Dunbar, M. (Michael), Amirault, J.D. (J. David), Gross, M. (Michael), Oxner, W. (William), Reardon, G. (Gerald), Richardson, C.G. (C. Glen), Trenholm, J.A. (J. Andrew), Wong, I. (Ivan), Trask, K. (Kelly), MacDonald, S. (Shelley), Dobbin, G. (Gwendolyn), Bicknell, R. (Ryan), Yach, J. (Jeff), Bardana, D. (Davide), Wood, G. (Gavin), Harrison, M. (Mark), Yen, D. (David), Lambert, S. (Sue), Howells, F. (Fiona), Ward, A. (Angela), Zalzal, P. (Paul), Brien, H. (Heather), Naumetz, V. (V.), Weening, B. (Brad), Wai, E.K. (Eugene K.), Papp, S. (Steve), Gofton, W.T. (Wade T.), Liew, A. (Allen), Kingwell, S.P. (Stephen P.), Johnson, G. (Garth), O'Neil, J. (Joseph), Roffey, D.M. (Darren M.), Borsella, V. (Vivian), Avram, V. (Victoria), Oliver, T.M. (Todd M.), Jones, V. (Vicki), Vogt, M. (Michelle), Jones, C.B. (Clifford B.), Ringler, J.R. (James R.), Endres, T.J. (Terrence J.), Sietsema, D.L. (Debra L.), Walker, J.E. (Jane E.), Broderick, J.S. (J. Scott), Goetz, D.R. (David R.), Pace, T.B. (Thomas B.), Schaller, T.M. (Thomas M.), Porter, S.E. (Scott E.), Beckish, M.L. (Michael L.), Adams, J.D. (John D.), Barden, B.B. (Benjamin B.), Creek, A.T. (Aaron T.), Finley, S.H. (Stephen H.), Foret, J.L. (Jonathan L.), Gudger, G.K. (Garland K.), Gurich, R.W. (Richard W.), Hill, A.D. (Austin D.), Hollenbeck, S.M. (Steven M.), Jackson, L.T. (Lyle T.), Kruse, K.K. (Kevin K.), Lackey, W.G. (Wesley G.), Langan, J.W. (Justin W.), Lee, J. (Julia), Leffler, L.C. (Lauren C.), Miller, T.J. (Timothy J.), Murphy, R.L. (R. Lee), O'Malley, L.K. (Lawrence K.), Peters, M.E. (Melissa E.), Price, D.M. (Dustin M.), Tanksley, J.A. (John A.), Torres, E.T. (Erick T.), Watson, D.J. (Dylan J.), Watson, S.T. (Scott T.), Tanner, S.L. (Stephanie L.), Snider, R.G. (Rebecca G.), Nastoff, L.A. (Lauren A.), Bielby, S.A. (Shea A.), Teasdall, R.J. (Robert J.), Switzer, J.A. (Julie A.), Cole, P.A. (Peter A.), Anderson, S.A. (Sarah A.), Lafferty, P.M. (Paul M.), Li, M. (Mengnai), Ly, T.V. (Thuan V.), Marston, S.B. (Scott B.), Foley, A.L. (Amy L.), Vang, S. (Sandy), Wright, D.M. (David M.), Marcantonio, A.J. (Andrew J.), Kain, M.S.H. (Michael S.H.), Iorio, R. (Richard), Specht, L.M. (Lawrence M.), Tilzey, J.F. (John F.), Lobo, M.J. (Margaret J.), Garfi, J.S. (John S.), Vallier, H.A. (Heather A.), Dolenc, A. (Andrea), Breslin, M. (Mary), Prayson, M.J. (Michael J.), Laughlin, R. (Richard), Rubino, L.J. (L. Joseph), May, J. (Jedediah), Rieser, G.R. (Geoffrey Ryan), Dulaney-Cripe, L. (Liz), Gayton, C. (Chris), Shaer, J. (James), Schrickel, T. (Tyson), Hileman, B. (Barbara), Gorczyca, J.T. (John T.), Gross, J.M. (Jonathan M.), Humphrey, C.A. (Catherine A.), Kates, S. (Stephen), Ketz, J.P. (John P.), Noble, K. (Krista), McIntyre, A.W. (Allison W.), Pecorella, K. (Kaili), Davis, C.A. (Craig A.), Weinerman, S. (Stuart), Weingarten, P. (Peter), Stull, P. (Philip), Lindenbaum, S. (Stephen), Hewitt, M. (Michael), Schwappach, J. (John), Baker, J.K. (Janell K.), Rutherford, T. (Tori), Newman, H. (Heike), Lieberman, S. (Shane), Finn, E. (Erin), Robbins, K. (Kristin), Hurley, M. (Meghan), Lyle, L. (Lindsey), Mitchell, K. (Khalis), Browner, K. (Kieran), Whatley, E. (Erica), Payton, K. (Krystal), Reeves, C. (Christina), Cannada, L.K. (Lisa K.), Karges, D.E. (David E.), Dawson, S.A. (Sarah A.), Mehta, S. (Samir), Esterhai, J. (John), Ahn, J. (Jaimo), Donegan, D. (Derek), Horan, A.D. (Annamarie D.), Hesketh, P.J. (Patrick J.), Bannister, E.R. (Evan R.), Keeve, J.P. (Jonathan P.), Anderson, C.G. (Christopher G.), McDonald, M.D. (Michael D.), Hoffman, J.M. (Jodi M.), Tarkin, I. (Ivan), Siska, P. (Peter), Gruen, G. (Gary), Evans, A. (Andrew), Farrell, D.J. (Dana J.), Irrgang, J. (James), Luther, A. (Arlene), Cross, W.W. (William W.), Cass, J.R. (Joseph R.), Sems, S.A. (Stephen A.), Torchia, M.E. (Michael E.), Scrabeck, T. (Tyson), Jenkins, M. (Mark), Dumais, J. (Jules), Romero, A.W. (Amanda W.), Sagebien, C.A. (Carlos A.), Butler, M.S. (Mark S.), Monica, J.T. (James T.), Seuffert, P. (Patricia), Hsu, J.R. (Joseph R.), Stinner, D. (Daniel), Ficke, J. (James), Charlton, M. (Michael), Napierala, M. (Matthew), Fan, M. (Mary), Tannoury, C. (Chadi), Carlisle, H. (Hope), Silva, H. (Heather), Archdeacon, M. (Michael), Finnan, R. (Ryan), Le, T. (Toan), Wyrick, J. (John), Hess, S. (Shelley), Brennan, M.L. (Michael L.), Probe, R. (Robert), Kile, E. (Evelyn), Mills, K. (Kelli), Clipper, L. (Lydia), Yu, M. (Michelle), Erwin, K. (Katie), Horwitz, D. (Daniel), Strohecker, K. (Kent), Swenson, T.K. (Teresa K.), Schmidt, A.H. (Andrew H.), Westberg, J.R. (Jerald R.), Aurang, K. (Kamran), Zohman, G. (Gary), Peterson, B. (Brett), Huff, R.B. (Roger B.), Baele, J. (Joseph), Weber, T. (Timothy), Edison, M. (Matt), McBeth, J.C. (Jessica Cooper), Shively, K. (Karl), Ertl, J.P. (Janos P.), Mullis, B. (Brian), Parr, J.A. (J. Andrew), Worman, R. (Ripley), Frizzell, V. (Valda), Moore, M.M. (Molly M.), DePaolo, C.J. (Charles J.), Alosky, R. (Rachel), Shell, L.E. (Leslie E.), Hampton, L. (Lynne), Shepard, S. (Stephanie), Nanney, T. (Tracy), Cuento, C. (Claudine), Cantu, R.V. (Robert V.), Henderson, E.R. (Eric R.), Eickhoff, L.S. (Linda S.), Hammerberg, E.M. (E. Mark), Stahel, P. (Philip), Hak, D. (David), Mauffrey, C. (Cyril), Henderson, C. (Corey), Gissel, H. (Hannah), Gibula, D. (Douglas), Zamorano, D.P. (David P.), Tynan, M.C. (Martin C.), Pourmand, D. (Deeba), Lawson, D. (Deanna), Crist, B.D. (Brett D.), Murtha, Y.M. (Yvonne M.), Anderson, L.K. (Linda K.), Linehan, C. (Colleen), Pilling, L. (Lindsey), Lewis, C.G. (Courtland G.), Caminiti, S. (Stephanie), Sullivan, R.J. (Raymond J.), Roper, E. (Elizabeth), Obremskey, W. (William), Kregor, P. (Philip), Richards, J.E. (Justin E.), Stringfellow, K. (Kenya), Dohm, M.P. (Michael P.), Zellar, A. (Abby), Segers, M.J.M. (Michiel), Zijl, J.A.C. (Jacco A.C.), Verhoeven, B. (Bart), Smits, A.B. (Anke B.), De Vries, J.P.P.M. (Jean Paul P.M.), Fioole, B. (Bram), Van Der Hoeven, H. (Henk), Theunissen, E.B.M. (Evert B.M.), De Vries Reilingh, T.S. (Tammo S.), Govaert, L. (Lonneke), Wittich, P. (Philippe), De Brauw, M. (Maurits), Wille, J.C. (Jan), Go, P.M.N.Y.M. (Peter M.N.Y.M.), Ritchie, E.D. (Ewan D.), Wessel, R.N. (Ronald N.), Hammacher, E.R. (Eric), Visser, G.A. (Gijs A.), Stockmann, H. (Heyn), Silvis, R. (Rob), Snellen, J.P. (Jaap P.), Rijbroek, B. (Bram), Scheepers, J.J. (Joris J.), Vermeulen, E.G.J. (Erik G.J.), Siroen, M.P.C. (Michiel P.C.), Vuylsteke, R. (Ronald), Brom, H.L.F., Rijna, H., Rijcke, P.A.R. (Piet), Koppert, C.L. (Cees L.), Buijk, S.E. (Steven E.), Groenendijk, R.P.R. (Richard), Dawson, I. (Imro), Tetteroo, G.W.M. (Geert), Bruijninckx, M.M.M. (Milko), Doornebosch, P. (Pascal), Graaf, E.J.R. (Eelco) de, Elst, M. (Maarten) van der, Pol, C. (Carmen) van der, Riet, M. (Martijne) van 't, Karsten, T.M. (Thomas), Vries, M.R. (Mark) de, Stassen, L.P.S. (Laurents P.S.), Schep, N.W.L. (Niels), Ben Schmidt, G. (G.), Hoffman, W.H. (W. H.), Poolman, R.W. (Rudolf), Simons, M.P., Heijden, F.H.W.M. (Frank) van der, Willems, W.J. (Jaap), De Meulemeester, F.R.A.J. (Frank R.A.J.), Hart, C.P. (Cor P.) van der, Turckan, K. (Kahn), Festen, S. (Sebastiaan), Nies, F. (Frank) de, Out, N.J.M. (Nico J.M.), Bosma, J. (Jan), Kampen, A. (A.) van, Biert, J. (Jan), Van Vugt, A.B. (Arie B.), Edwards, M.J.R. (Michael J.R.), Blokhuis, T.J. (Taco J.), Frölke, J.P.M. (Jan Paul), Geeraedts, L.M.G. (Leo M.G.), Gardeniers, J.W.M. (Jean W.M.), Tan, E.C.T.H. (Edward C.T.H.), Poelhekke, L.M.S.J., De Waal Malefijt, M.C. (Maarten C.), Schreurs, B. (Bart), Roukema, G.R. (Gert), Josaputra, H.A. (Hong A.), Keller, P. (Paul), De Rooij, P.D. (Peter D.), Kuiken, H. (Hans), Boxma, H. (Han), Cleffken, B.I. (Berry), Liem, R. (Ronald), Rhemrev, S. (Steven), Bosman, C.H.R. (Coks H.R.), De Mol Van Otterloo, A. (Alexander), Hoogendoorn, J. (Jochem), Vries, A.C. (Alexander) de, Meylaerts, S.A.G. (Sven), Verhofstad, M.H.J. (Michiel), Meijer, J. (Joost), Van Egmond, T. (Teun), Van Der Brand, I. (Igor), Patka, P. (Peter), Eversdijk, M.G. (Martin), Peters, R. (Rolf), Hartog, D. (Dennis) den, Waes, O.J.F. (Oscar) van, Oprel, P.P. (Pim), Vis, H.M. (Harm) van der, Campo, M. (Martin), Verhagen, R. (Ronald), Albers, G.H.R. (G.H. Robert), Zurcher, A.W. (Arthur W.), Simmermacher, R.K.J., Van Mulken, J. (Jeroen), Wessem, K.J.P. van, Van Gaalen, S.M. (Steven M.), Leenen, L.P.H., Bronkhorst, M.W.G.A. (Maarten), Guicherit, O.R. (Onno R.), Goslings, J.C. (Carel), Ponsen, K.J. (Kees-jan), Bhatia, M. (Mahesh), Arora, V. (Vinod), Tyagi, V. (Vivek), Bedi, H. (Harvinder), Carr, A. (Ashley), Curry, H. (Hamish), Chia, A. (Andrew), Csongvay, S. (Steve), Donohue, C. (Craig), Doig, S. (Stephen), Edwards, E. (Elton), Etherington, G. (Greg), Esser, M. (Max), Gong, A. (Andrew), Jain, A. (Arvind), Li, D. (Doug), Miller, R. (Russell), Moaveni, A. (Ash), Russ, M. (Matthias), Ton, L. (Lu), Wang, O. (Otis), Dowrick, A. (Adam), Murdoch, Z. (Zoe), Sage, C. (Claire), Frihagen, F. (Frede), Clarke-Jenssen, J. (John), Hjorthaug, G. (Geir), Ianssen, T. (Torben), Amundsen, A. (Asgeir), Brattgjerd, J.E. (Jan Egil), Borch, T. (Tor), Bøe, B. (Berthe), Flatøy, B. (Bernhard), Hasselund, S. (Sondre), Haug, K.J. (Knut Jørgen), Hemlock, K. (Kim), Hoseth, T.M. (Tor Magne), Jomaas, G. (Geir), Kibsgård, T. (Thomas), Lona, T. (Tarjei), Moatshe, G. (Gilbert), Müller, O. (Oliver), Molund, M. (Marius), Nicolaisen, T. (Tor), Nilsen, F. (Fredrik), Rydinge, J. (Jonas), Smedsrud, M. (Morten), Stødle, A. (Are), Trommer, A. (Axel), Ugland, S. (Stein), Karlsten, A. (Anders), Ekås, G. (Guri), Vesterhus, E.B. (Elise Berg), Brekke, A.C. (Anne Christine), Gupta, A. (Ajay), Jain, N. (Neeraj), Khan, F. (Farah), Sharma, A. (Ateet), Sanghavi, A. (Amir), Trivedi, M. (Mittal), Rai, A. (Anil), Subash, (), Rai, K. (Kamal), Yadav, V. (Vineet), Singh, S. (Sanjay), Tetsworth, K. (Kevin), Donald, G. (Geoff), Weinrauch, P. (Patrick), Pincus, P. (Paul), Yang, S. (Steven), Halliday, B. (Brett), Gervais, T. (Trevor), Holt, M. (Michael), Flynn, A. (Annette), Prasad, A.S. (Amal Shankar), Mishra, V. (Vimlesh), Sundaresh, D.C. (D. C.), Khanna, A. (Angshuman), Cherian, J.J. (Joe Joseph), Olakkengil, D.J. (Davy J), Sharma, G. (Gaurav), Pirpiris, M. (Marinis), Love, D. (David), Bucknill, A. (Andrew), Farrugia, R.J. (Richard J), Pape, H.-C. (Hans-Christoph), Knobe, M. (Matthias), Pfeifer, R. (Roman), Hull, P. (Peter), Lewis, S. (Sophie), Evans, S. (Simone), Nanda, R. (Rajesh), Logishetty, R. (Rajanikanth), Anand, S. (Sanjeev), Bowler, C. (Carol), Dadi, A. (Akhil), Palla, N. (Naveen), Ganguly, U. (Utsav), Rai, B.S. (B. Sachidananda), Rajakumar, J. (Janakiraman), Jennings, A. (Andrew), Chuter, G. (Graham), Rose, G. (Glynis), Horner, G. (Gillian), Clark, C. (Callum), Eke, K. (Kate), Reed, M.R. (Mike), Inman, D. (Dominic), Herriott, C. (Chris), Dobb, C. (Christine), Sprague, S. (Sheila), Schemitsch, E.H. (Emil H.), Swiontkowski, M.F. (Marc ), Della Rocca, G.J. (Gregory J.), Jeray, K.J. (Kyle J.), Liew, S. (Susan), Slobogean, G.P. (Gerard P.), Bzovsky, S. (Sofia), Heels-Ansdell, D. (Diane), Zhou, Q. (Qi), Bhandari, M. (Mohit), Sprag, S. (Sheila), Devereaux, P.J., Guyatt, G.H. (Gordon), Heetveld, M.J. (Martin J.), Richardson, M. (Martin), Thabane, L. (Lehana), Tornetta III, P. (Paul), Walter, S.D. (Stephen D.), McKay, P. (Paula), Scott, T. (Taryn), Garibaldi, A. (Alisha), Viveiros, H. (Helena), Swinton, M. (Marilyn), Gichuru, M. (Mark), Buckingham, L. (Lisa), Duraikannan, A. (Aravin), Maddock, D. (Deborah), Simunovic, N. (Nicole), Agel, J. (Julie), Lieshout, E.M.M. (Esther) van, Zielinski, S.M. (Stephanie), Rangan, A. (Amar), Hanusch, B.C. (Birgit C.), Kottam, L. (Lucksy), Clarkson, R. (Rachel), Haverlag, R. (Robert), McCormack, R. (Robert), Apostle, K. (Kelly), Boyer, D. (Dory), Moola, F. (Farhad), Perey, B. (Bertrand), Stone, T. (Trevor), Viskontas, D. (Darius), Lemke, H.M. (H. Michael), Zomar, M. (Mauri), Moon, K. (Karyn), Moon, R. (Raely), Oatt, A. (Amber), Buckley, R.E. (Richard E.), Duffy, P. (Paul), Korley, R. (Robert), Puloski, S. (Shannon), Powell, J. (James), Johnston, K. (Kelly), Carcary, K. (Kimberly), Lorenzo, M. (Melissa), McKercher, R. (Ross), Sanders, D. (David), MacLeod, M. (Mark), Lawendy, A.-R. (Abdel-Rahman), Tieszer, C. (Christina), Stephen, D. (David), Kreder, H. (Hans), Jenkinson, R. (Richard), Nousiainen, M. (Markku), Axelrod, T. (Terry), Murnaghan, J. (John), Nam, D. (Diane), Wadey, V. (Veronica), Yee, A. (Albert), Milner, K. (Katrine), Kunz, M. (Monica), Ghent, W. (Wesley), McKee, M.D. (Michael D.), Hall, J.A. (Jeremy A.), Nauth, A. (Aaron), Ahn, H. (Henry), Whelan, D.B. (Daniel B.), Vicente, M.R. (Milena R.), Wild, L.M. (Lisa M.), Khan, R.M. (Ryan M.), Hidy, J.T. (Jennifer T.), Coles, C. (Chad), Leighton, R. (Ross), Biddulph, M. (Michael), Johnston, D. (David), Glazebrook, M. (Mark), Alexander, D. (David), Coady, C. (Catherine), Dunbar, M. (Michael), Amirault, J.D. (J. David), Gross, M. (Michael), Oxner, W. (William), Reardon, G. (Gerald), Richardson, C.G. (C. Glen), Trenholm, J.A. (J. Andrew), Wong, I. (Ivan), Trask, K. (Kelly), MacDonald, S. (Shelley), Dobbin, G. (Gwendolyn), Bicknell, R. (Ryan), Yach, J. (Jeff), Bardana, D. (Davide), Wood, G. (Gavin), Harrison, M. (Mark), Yen, D. (David), Lambert, S. (Sue), Howells, F. (Fiona), Ward, A. (Angela), Zalzal, P. (Paul), Brien, H. (Heather), Naumetz, V. (V.), Weening, B. (Brad), Wai, E.K. (Eugene K.), Papp, S. (Steve), Gofton, W.T. (Wade T.), Liew, A. (Allen), Kingwell, S.P. (Stephen P.), Johnson, G. (Garth), O'Neil, J. (Joseph), Roffey, D.M. (Darren M.), Borsella, V. (Vivian), Avram, V. (Victoria), Oliver, T.M. (Todd M.), Jones, V. (Vicki), Vogt, M. (Michelle), Jones, C.B. (Clifford B.), Ringler, J.R. (James R.), Endres, T.J. (Terrence J.), Sietsema, D.L. (Debra L.), Walker, J.E. (Jane E.), Broderick, J.S. (J. Scott), Goetz, D.R. (David R.), Pace, T.B. (Thomas B.), Schaller, T.M. (Thomas M.), Porter, S.E. (Scott E.), Beckish, M.L. (Michael L.), Adams, J.D. (John D.), Barden, B.B. (Benjamin B.), Creek, A.T. (Aaron T.), Finley, S.H. (Stephen H.), Foret, J.L. (Jonathan L.), Gudger, G.K. (Garland K.), Gurich, R.W. (Richard W.), Hill, A.D. (Austin D.), Hollenbeck, S.M. (Steven M.), Jackson, L.T. (Lyle T.), Kruse, K.K. (Kevin K.), Lackey, W.G. (Wesley G.), Langan, J.W. (Justin W.), Lee, J. (Julia), Leffler, L.C. (Lauren C.), Miller, T.J. (Timothy J.), Murphy, R.L. (R. Lee), O'Malley, L.K. (Lawrence K.), Peters, M.E. (Melissa E.), Price, D.M. (Dustin M.), Tanksley, J.A. (John A.), Torres, E.T. (Erick T.), Watson, D.J. (Dylan J.), Watson, S.T. (Scott T.), Tanner, S.L. (Stephanie L.), Snider, R.G. (Rebecca G.), Nastoff, L.A. (Lauren A.), Bielby, S.A. (Shea A.), Teasdall, R.J. (Robert J.), Switzer, J.A. (Julie A.), Cole, P.A. (Peter A.), Anderson, S.A. (Sarah A.), Lafferty, P.M. (Paul M.), Li, M. (Mengnai), Ly, T.V. (Thuan V.), Marston, S.B. (Scott B.), Foley, A.L. (Amy L.), Vang, S. (Sandy), Wright, D.M. (David M.), Marcantonio, A.J. (Andrew J.), Kain, M.S.H. (Michael S.H.), Iorio, R. (Richard), Specht, L.M. (Lawrence M.), Tilzey, J.F. (John F.), Lobo, M.J. (Margaret J.), Garfi, J.S. (John S.), Vallier, H.A. (Heather A.), Dolenc, A. (Andrea), Breslin, M. (Mary), Prayson, M.J. (Michael J.), Laughlin, R. (Richard), Rubino, L.J. (L. Joseph), May, J. (Jedediah), Rieser, G.R. (Geoffrey Ryan), Dulaney-Cripe, L. (Liz), Gayton, C. (Chris), Shaer, J. (James), Schrickel, T. (Tyson), Hileman, B. (Barbara), Gorczyca, J.T. (John T.), Gross, J.M. (Jonathan M.), Humphrey, C.A. (Catherine A.), Kates, S. (Stephen), Ketz, J.P. (John P.), Noble, K. (Krista), McIntyre, A.W. (Allison W.), Pecorella, K. (Kaili), Davis, C.A. (Craig A.), Weinerman, S. (Stuart), Weingarten, P. (Peter), Stull, P. (Philip), Lindenbaum, S. (Stephen), Hewitt, M. (Michael), Schwappach, J. (John), Baker, J.K. (Janell K.), Rutherford, T. (Tori), Newman, H. (Heike), Lieberman, S. (Shane), Finn, E. (Erin), Robbins, K. (Kristin), Hurley, M. (Meghan), Lyle, L. (Lindsey), Mitchell, K. (Khalis), Browner, K. (Kieran), Whatley, E. (Erica), Payton, K. (Krystal), Reeves, C. (Christina), Cannada, L.K. (Lisa K.), Karges, D.E. (David E.), Dawson, S.A. (Sarah A.), Mehta, S. (Samir), Esterhai, J. (John), Ahn, J. (Jaimo), Donegan, D. (Derek), Horan, A.D. (Annamarie D.), Hesketh, P.J. (Patrick J.), Bannister, E.R. (Evan R.), Keeve, J.P. (Jonathan P.), Anderson, C.G. (Christopher G.), McDonald, M.D. (Michael D.), Hoffman, J.M. (Jodi M.), Tarkin, I. (Ivan), Siska, P. (Peter), Gruen, G. (Gary), Evans, A. (Andrew), Farrell, D.J. (Dana J.), Irrgang, J. (James), Luther, A. (Arlene), Cross, W.W. (William W.), Cass, J.R. (Joseph R.), Sems, S.A. (Stephen A.), Torchia, M.E. (Michael E.), Scrabeck, T. (Tyson), Jenkins, M. (Mark), Dumais, J. (Jules), Romero, A.W. (Amanda W.), Sagebien, C.A. (Carlos A.), Butler, M.S. (Mark S.), Monica, J.T. (James T.), Seuffert, P. (Patricia), Hsu, J.R. (Joseph R.), Stinner, D. (Daniel), Ficke, J. (James), Charlton, M. (Michael), Napierala, M. (Matthew), Fan, M. (Mary), Tannoury, C. (Chadi), Carlisle, H. (Hope), Silva, H. (Heather), Archdeacon, M. (Michael), Finnan, R. (Ryan), Le, T. (Toan), Wyrick, J. (John), Hess, S. (Shelley), Brennan, M.L. (Michael L.), Probe, R. (Robert), Kile, E. (Evelyn), Mills, K. (Kelli), Clipper, L. (Lydia), Yu, M. (Michelle), Erwin, K. (Katie), Horwitz, D. (Daniel), Strohecker, K. (Kent), Swenson, T.K. (Teresa K.), Schmidt, A.H. (Andrew H.), Westberg, J.R. (Jerald R.), Aurang, K. (Kamran), Zohman, G. (Gary), Peterson, B. (Brett), Huff, R.B. (Roger B.), Baele, J. (Joseph), Weber, T. (Timothy), Edison, M. (Matt), McBeth, J.C. (Jessica Cooper), Shively, K. (Karl), Ertl, J.P. (Janos P.), Mullis, B. (Brian), Parr, J.A. (J. Andrew), Worman, R. (Ripley), Frizzell, V. (Valda), Moore, M.M. (Molly M.), DePaolo, C.J. (Charles J.), Alosky, R. (Rachel), Shell, L.E. (Leslie E.), Hampton, L. (Lynne), Shepard, S. (Stephanie), Nanney, T. (Tracy), Cuento, C. (Claudine), Cantu, R.V. (Robert V.), Henderson, E.R. (Eric R.), Eickhoff, L.S. (Linda S.), Hammerberg, E.M. (E. Mark), Stahel, P. (Philip), Hak, D. (David), Mauffrey, C. (Cyril), Henderson, C. (Corey), Gissel, H. (Hannah), Gibula, D. (Douglas), Zamorano, D.P. (David P.), Tynan, M.C. (Martin C.), Pourmand, D. (Deeba), Lawson, D. (Deanna), Crist, B.D. (Brett D.), Murtha, Y.M. (Yvonne M.), Anderson, L.K. (Linda K.), Linehan, C. (Colleen), Pilling, L. (Lindsey), Lewis, C.G. (Courtland G.), Caminiti, S. (Stephanie), Sullivan, R.J. (Raymond J.), Roper, E. (Elizabeth), Obremskey, W. (William), Kregor, P. (Philip), Richards, J.E. (Justin E.), Stringfellow, K. (Kenya), Dohm, M.P. (Michael P.), Zellar, A. (Abby), Segers, M.J.M. (Michiel), Zijl, J.A.C. (Jacco A.C.), Verhoeven, B. (Bart), Smits, A.B. (Anke B.), De Vries, J.P.P.M. (Jean Paul P.M.), Fioole, B. (Bram), Van Der Hoeven, H. (Henk), Theunissen, E.B.M. (Evert B.M.), De Vries Reilingh, T.S. (Tammo S.), Govaert, L. (Lonneke), Wittich, P. (Philippe), De Brauw, M. (Maurits), Wille, J.C. (Jan), Go, P.M.N.Y.M. (Peter M.N.Y.M.), Ritchie, E.D. (Ewan D.), Wessel, R.N. (Ronald N.), Hammacher, E.R. (Eric), Visser, G.A. (Gijs A.), Stockmann, H. (Heyn), Silvis, R. (Rob), Snellen, J.P. (Jaap P.), Rijbroek, B. (Bram), Scheepers, J.J. (Joris J.), Vermeulen, E.G.J. (Erik G.J.), Siroen, M.P.C. (Michiel P.C.), Vuylsteke, R. (Ronald), Brom, H.L.F., Rijna, H., Rijcke, P.A.R. (Piet), Koppert, C.L. (Cees L.), Buijk, S.E. (Steven E.), Groenendijk, R.P.R. (Richard), Dawson, I. (Imro), Tetteroo, G.W.M. (Geert), Bruijninckx, M.M.M. (Milko), Doornebosch, P. (Pascal), Graaf, E.J.R. (Eelco) de, Elst, M. (Maarten) van der, Pol, C. (Carmen) van der, Riet, M. (Martijne) van 't, Karsten, T.M. (Thomas), Vries, M.R. (Mark) de, Stassen, L.P.S. (Laurents P.S.), Schep, N.W.L. (Niels), Ben Schmidt, G. (G.), Hoffman, W.H. (W. H.), Poolman, R.W. (Rudolf), Simons, M.P., Heijden, F.H.W.M. (Frank) van der, Willems, W.J. (Jaap), De Meulemeester, F.R.A.J. (Frank R.A.J.), Hart, C.P. (Cor P.) van der, Turckan, K. (Kahn), Festen, S. (Sebastiaan), Nies, F. (Frank) de, Out, N.J.M. (Nico J.M.), Bosma, J. (Jan), Kampen, A. (A.) van, Biert, J. (Jan), Van Vugt, A.B. (Arie B.), Edwards, M.J.R. (Michael J.R.), Blokhuis, T.J. (Taco J.), Frölke, J.P.M. (Jan Paul), Geeraedts, L.M.G. (Leo M.G.), Gardeniers, J.W.M. (Jean W.M.), Tan, E.C.T.H. (Edward C.T.H.), Poelhekke, L.M.S.J., De Waal Malefijt, M.C. (Maarten C.), Schreurs, B. (Bart), Roukema, G.R. (Gert), Josaputra, H.A. (Hong A.), Keller, P. (Paul), De Rooij, P.D. (Peter D.), Kuiken, H. (Hans), Boxma, H. (Han), Cleffken, B.I. (Berry), Liem, R. (Ronald), Rhemrev, S. (Steven), Bosman, C.H.R. (Coks H.R.), De Mol Van Otterloo, A. (Alexander), Hoogendoorn, J. (Jochem), Vries, A.C. (Alexander) de, Meylaerts, S.A.G. (Sven), Verhofstad, M.H.J. (Michiel), Meijer, J. (Joost), Van Egmond, T. (Teun), Van Der Brand, I. (Igor), Patka, P. (Peter), Eversdijk, M.G. (Martin), Peters, R. (Rolf), Hartog, D. (Dennis) den, Waes, O.J.F. (Oscar) van, Oprel, P.P. (Pim), Vis, H.M. (Harm) van der, Campo, M. (Martin), Verhagen, R. (Ronald), Albers, G.H.R. (G.H. Robert), Zurcher, A.W. (Arthur W.), Simmermacher, R.K.J., Van Mulken, J. (Jeroen), Wessem, K.J.P. van, Van Gaalen, S.M. (Steven M.), Leenen, L.P.H., Bronkhorst, M.W.G.A. (Maarten), Guicherit, O.R. (Onno R.), Goslings, J.C. (Carel), Ponsen, K.J. (Kees-jan), Bhatia, M. (Mahesh), Arora, V. (Vinod), Tyagi, V. (Vivek), Bedi, H. (Harvinder), Carr, A. (Ashley), Curry, H. (Hamish), Chia, A. (Andrew), Csongvay, S. (Steve), Donohue, C. (Craig), Doig, S. (Stephen), Edwards, E. (Elton), Etherington, G. (Greg), Esser, M. (Max), Gong, A. (Andrew), Jain, A. (Arvind), Li, D. (Doug), Miller, R. (Russell), Moaveni, A. (Ash), Russ, M. (Matthias), Ton, L. (Lu), Wang, O. (Otis), Dowrick, A. (Adam), Murdoch, Z. (Zoe), Sage, C. (Claire), Frihagen, F. (Frede), Clarke-Jenssen, J. 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(Michael), Flynn, A. (Annette), Prasad, A.S. (Amal Shankar), Mishra, V. (Vimlesh), Sundaresh, D.C. (D. C.), Khanna, A. (Angshuman), Cherian, J.J. (Joe Joseph), Olakkengil, D.J. (Davy J), Sharma, G. (Gaurav), Pirpiris, M. (Marinis), Love, D. (David), Bucknill, A. (Andrew), Farrugia, R.J. (Richard J), Pape, H.-C. (Hans-Christoph), Knobe, M. (Matthias), Pfeifer, R. (Roman), Hull, P. (Peter), Lewis, S. (Sophie), Evans, S. (Simone), Nanda, R. (Rajesh), Logishetty, R. (Rajanikanth), Anand, S. (Sanjeev), Bowler, C. (Carol), Dadi, A. (Akhil), Palla, N. (Naveen), Ganguly, U. (Utsav), Rai, B.S. (B. Sachidananda), Rajakumar, J. (Janakiraman), Jennings, A. (Andrew), Chuter, G. (Graham), Rose, G. (Glynis), Horner, G. (Gillian), Clark, C. (Callum), Eke, K. (Kate), Reed, M.R. (Mike), Inman, D. (Dominic), Herriott, C. (Chris), and Dobb, C. (Christine)

Abstract

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (for

Published
2018
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24. Factors Associated With Revision Surgery After Internal Fixation of Hip Fractures

Author

Sprague, S., Schemitsch, E.H., Swiontkowski, M., Rocca, G.J. Della, Jeray, K.J., Liew, S., Slobogean, G.P., Bzovsky, S., Heels-Ansdell, D., Kampen, A. van, Biert, J., Vugt, A.B. van, Edwards, M.J.R., Blokhuis, T.J., Frolke, J.P.M., Geeraedts, L.M.G., Gardeniers, J.W.M., Tan, E.C.T.H., Poelhekke, L.M.S.J., Waal Malefijt, M.C. de, Schreurs, B.W., Zhou, Q., Bhandari, M., Sprague, S., Schemitsch, E.H., Swiontkowski, M., Rocca, G.J. Della, Jeray, K.J., Liew, S., Slobogean, G.P., Bzovsky, S., Heels-Ansdell, D., Kampen, A. van, Biert, J., Vugt, A.B. van, Edwards, M.J.R., Blokhuis, T.J., Frolke, J.P.M., Geeraedts, L.M.G., Gardeniers, J.W.M., Tan, E.C.T.H., Poelhekke, L.M.S.J., Waal Malefijt, M.C. de, Schreurs, B.W., Zhou, Q., and Bhandari, M.

Abstract

Item does not contain fulltext, BACKGROUND: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. METHODS: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. RESULTS: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (for every 5-point increase) (HR 1.19, 95% CI 1.02-1.39; P = 0.027), displaced fracture (HR 2.16, 95% CI 1.44-3.23; P < 0.001), unacceptable quality of implant placement (HR 2.70, 95% CI 1.59-4.55; P < 0.001), and smokers treated with cancellous screws versus smokers treated with a sliding hip screw (HR 2.94, 95% CI 1.35-6.25; P = 0.006). Additionally, for every 10-year decrease in age, participants experienced an average increased risk of 39% for hardware removal. CONCLUSIONS: Results of this study may inform future research by identifying high-risk patients who may be better treated with arthroplasty and may benefit from adjuncts to care (HR 1.39, 95% CI 1.05-1.85; P = 0.020). LEVEL OF EVIDENCE: Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.

Published
2018

26. Technical Aspects and Validation of a New Biofeedback System for Measuring Lower Limb Loading in the Dynamic Situation

Author

Raaben, M., Holtslag, H.R., Augustine, R., van Merkerk, R.O., Koopman, Hubertus F.J.M., Blokhuis, T.J., and Faculty of Engineering Technology

Subjects
IR-104620, METIS-321972
Abstract

Background: A variety of techniques for measuring lower limb loading exists, each with their own limitations. A new ambulatory biofeedback system was developed to overcome these limitations. In this study, we described the technical aspects and validated the accuracy of this system. Methods: A bench press was used to validate the system in the static situation. Ten healthy volunteers were measured by the new biofeedback system and a dual-belt instrumented treadmill to validate the system in the dynamic situation. Results: Bench press results showed that the sensor accurately measured peak loads up to 1000 N in the static situation. In the healthy volunteers, the load curves measured by the biofeedback system were similar to the treadmill. However, the peak loads and loading rates were lower in the biofeedback system in all participants at all speeds. Conclusions: Advanced sensor technologies used in the new biofeedback system resulted in highly accurate measurements in the static situation. The position of the sensor and the design of the biofeedback system should be optimized to improve results in the dynamic situation

Published
2017

28. Timing of definitive fixation of major long bone fractures: Can fat embolism syndrome be prevented?

Author

Blokhuis, T.J., Pape, H.C., Frolke, J.P.M., Blokhuis, T.J., Pape, H.C., and Frolke, J.P.M.

Abstract

Item does not contain fulltext, Fat embolism is common in patients with major fractures, but leads to devastating consequences, named fat embolism syndrome (FES) in some. Despite advances in treatment strategies regarding the timing of definitive fixation of major fractures, FES still occurs in patients. In this overview, current literature is reviewed and optimal treatment strategies for patients with multiple traumatic injuries, including major fractures, are discussed. Considering the multifactorial etiology of FES, including mechanical and biochemical pathways, FES cannot be prevented in all patients. However, screening for symptoms of FES should be standard in the pre-operative work-up of these patients, prior to definitive fixation of major fractures.

Published
2017

29. Vitamin D Use and Health Outcomes After Surgery for Hip Fracture

Author

Sprague, S., Slobogean, G.P., Bogoch, E., Petrisor, B., Garibaldi, A., O'Hara, N., Bhandari, M., Biert, J., Vugt, A.B. van, Edwards, M.J.R., Blokhuis, T.J., Frolke, J.P.M., Geeraedts, L.M.G., Gardeniers, J.W.M., Tan, E.C.T.H., Poelhekke, L.M.S.J., Waal Malefijt, M.C. de, Schreurs, B.W., Herriott, C., Dobb, C., Sprague, S., Slobogean, G.P., Bogoch, E., Petrisor, B., Garibaldi, A., O'Hara, N., Bhandari, M., Biert, J., Vugt, A.B. van, Edwards, M.J.R., Blokhuis, T.J., Frolke, J.P.M., Geeraedts, L.M.G., Gardeniers, J.W.M., Tan, E.C.T.H., Poelhekke, L.M.S.J., Waal Malefijt, M.C. de, Schreurs, B.W., Herriott, C., and Dobb, C.

Abstract

Item does not contain fulltext, Daily administration of vitamin D is important for maintaining bone homeostasis. The orthopedic community has shown increased interest in vitamin D supplementation and patient outcomes after fracture. The current study used data from a large hip fracture trial to determine the proportion of patients who consistently used vitamin D after hip fracture surgery and to determine whether supplementation was associated with improved health-related quality of life and reduced reoperation rates. The FAITH study is a multicenter trial of elderly patients with femoral neck fracture treated with internal fixation. The current study asked a subset of patients included in the FAITH study about vitamin D supplementation and categorized them as consistent users, inconsistent users, or nonusers. This study also evaluated whether supplementation was associated with improved quality of life and reduced reoperation rates. The final analysis included 573 patients (mean age, 74.1 years; female, 66.3%; nondis-placed fractures, 72.4%). A total of 18.7% of participants reported no use of vitamin D, 35.6% reported inconsistent use, and 45.7% reported consistent use. Adjusted analysis found that consistent supplementation was associated with a 2.42 increase of the Short Form-12 physical component score 12 months postoperatively (P=.033). However, supplementation was not associated with reduced reoperation rates (P=.386). Despite guidelines recommending vitamin D supplementation, a low proportion of elderly patients with hip fracture use vitamin D consistently, suggesting a need for additional strategies to promote compliance. This study found that the use of vitamin D was associated with a statistically significant but not clinically significant improvement in health-related quality of life after hip fracture. Further research is needed to confirm these findings. [Orthopedics. 2017; 40(5):e868-e875.].

Published
2017

30. Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial

Author

Nauth, A. (Aaron), Creek, A.T. (Aaron T.), Zellar, A. (Abby), Lawendy, A.-R. (Abdel-Rahman), Dowrick, A. (Adam), Gupta, A. (Ajay), Dadi, A. (Akhil), Kampen, A. (A.) van, Yee, A. (Albert), Vries, A.C. (Alexander) de, de Mol van Otterloo, A. (Alexander), Garibaldi, A. (Alisha), Liew, A. (Allen), McIntyre, A.W. (Allison W.), Prasad, A.S. (Amal Shankar), Romero, A.W. (Amanda W.), Rangan, A. (Amar), Oatt, A. (Amber), Sanghavi, A. (Amir), Foley, A.L. (Amy L.), Karlsten, A. (Anders), Dolenc, A. (Andrea), Bucknill, A. (Andrew), Chia, A. (Andrew), Evans, A. (Andrew), Gong, A. (Andrew), Schmidt, A.H. (Andrew H.), Marcantonio, A.J. (Andrew J.), Jennings, A. (Andrew), Ward, A. (Angela), Khanna, A. (Angshuman), Rai, A. (Anil), Smits, A.B. (Anke B.), Horan, A.D. (Annamarie D.), Brekke, A.C. (Anne Christine), Flynn, A. (Annette), Duraikannan, A. (Aravin), Stødle, A. (Are), van Vugt, A.B. (Arie B.), Luther, A. (Arlene), Zurcher, A.W. (Arthur W.), Jain, A. (Arvind), Amundsen, A. (Asgeir), Moaveni, A. (Ash), Carr, A. (Ashley), Sharma, A. (Ateet), Hill, A.D. (Austin D.), Trommer, A. (Axel), Rai, B.S. (B. Sachidananda), Hileman, B. (Barbara), Schreurs, B. (Bart), Verhoeven, B. (Bart), Barden, B.B. (Benjamin B.), Flatøy, B. (Bernhard), Cleffken, B.I. (Berry), Bøe, B. (Berthe), Perey, B. (Bertrand), Hanusch, B.C. (Birgit C.), Weening, B. (Brad), Fioole, B. (Bram), Rijbroek, B. (Bram), Crist, B.D. (Brett D.), Halliday, B. (Brett), Peterson, B. (Brett), Mullis, B. (Brian), Richardson, C.G. (C. Glen), Clark, C. (Callum), Sagebien, C.A. (Carlos A.), Pol, C. (Carmen) van der, Bowler, C. (Carol), Humphrey, C.A. (Catherine A.), Coady, C. (Catherine), Koppert, C.L. (Cees L.), Coles, C. (Chad), Tannoury, C. (Chadi), DePaolo, C.J. (Charles J.), Gayton, C. (Chris), Herriott, C. (Chris), Reeves, C. (Christina), Tieszer, C. (Christina), Dobb, C. (Christine), Anderson, C.G. (Christopher G.), Sage, C. (Claire), Cuento, C. (Claudine), Jones, C.B. (Clifford B.), Bosman, C.H.R. (Coks H.R.), Linehan, C. (Colleen), Hart, C.P. (Cor P.) van der, Henderson, C. (Corey), Lewis, C.G. (Courtland G.), Davis, C.A. (Craig A.), Donohue, C. (Craig), Mauffrey, C. (Cyril), Sundaresh, D.C. (D. C.), Farrell, D.J. (Dana J.), Whelan, D.B. (Daniel B.), Horwitz, D. (Daniel), Stinner, D. (Daniel), Viskontas, D. (Darius), Roffey, D.M. (Darren M.), Alexander, D. (David), Karges, D.E. (David E.), Hak, D. (David), Johnston, D. (David), Love, D. (David), Wright, D.M. (David M.), Zamorano, D.P. (David P.), Goetz, D.R. (David R.), Sanders, D. (David), Stephen, D. (David), Yen, D. (David), Bardana, D. (Davide), Olakkengil, D.J. (Davy J), Lawson, D. (Deanna), Maddock, D. (Deborah), Sietsema, D.L. (Debra L.), Pourmand, D. (Deeba), Hartog, D. (Dennis) den, Donegan, D. (Derek), Heels-Ansdell, D. (Diane), Nam, D. (Diane), Inman, D. (Dominic), Boyer, D. (Dory), Li, D. (Doug), Gibula, D. (Douglas), Price, D.M. (Dustin M.), Watson, D.J. (Dylan J.), Hammerberg, E.M. (E. Mark), Tan, E.T.C.H. (Edward T.C.H.), Graaf, E.J.R. (Eelco) de, Vesterhus, E.B. (Elise Berg), Roper, E. (Elizabeth), Edwards, E. (Elton), Schemitsch, E.H. (Emil), Hammacher, E.R. (Eric), Henderson, E.R. (Eric R.), Whatley, E. (Erica), Torres, E.T. (Erick T.), Vermeulen, E.G.J. (Erik G.J.), Finn, E. (Erin), Lieshout, E.M.M. (Esther) van, Wai, E.K. (Eugene K.), Bannister, E.R. (Evan R.), Kile, E. (Evelyn), Theunissen, E.B.M. (Evert B.M.), Ritchie, E.D. (Ewan D.), Khan, F. (Farah), Moola, F. (Farhad), Howells, F. (Fiona), Nies, F. (Frank) de, Heijden, F.H.W.M. (Frank) van der, de Meulemeester, F.R.A.J. (Frank R.A.J.), Frihagen, F. (Frede), Nilsen, F. (Fredrik), Schmidt, G.B. (G. Ben), Albers, G.H.R. (G.H. Robert), Gudger, G.K. (Garland K.), Johnson, G. (Garth), Gruen, G. (Gary), Zohman, G. (Gary), Sharma, G. (Gaurav), Wood, G. (Gavin), Tetteroo, G.W.M. (Geert), Hjorthaug, G. (Geir), Jomaas, G. (Geir), Donald, G. (Geoff), Rieser, G.R. (Geoffrey Ryan), Reardon, G. (Gerald), Slobogean, G.P. (Gerard P.), Roukema, G.R. (Gert), Visser, G.A. (Gijs A.), Moatshe, G. (Gilbert), Horner, G. (Gillian), Rose, G. (Glynis), Guyatt, G. (Gordon), Chuter, G. (Graham), Etherington, G. (Greg), Rocca, G.J.D. (Gregory J. Della), Ekås, G. (Guri), Dobbin, G. (Gwendolyn), Lemke, H.M. (H. Michael), Curry, H. (Hamish), Boxma, H. (Han), Gissel, H. (Hannah), Kreder, H. (Hans), Kuiken, H. (Hans), Brom, H.L.F., Pape, H.-C. (Hans-Christoph), Vis, H.M. (Harm) van der, Bedi, H. (Harvinder), Vallier, H.A. (Heather A.), Brien, H. (Heather), Silva, H. (Heather), Newman, H. (Heike), Viveiros, H. (Helena), van der Hoeven, H. (Henk), Ahn, H. (Henry), Johal, H. (Herman), Rijna, H., Stockmann, H. (Heyn), Josaputra, H.A. (Hong A.), Carlisle, H. (Hope), van der Brand, I. (Igor), Dawson, I. (Imro), Tarkin, I. (Ivan), Wong, I. (Ivan), Parr, J.A. (J. Andrew), Trenholm, J.A. (J. Andrew), Goslings, J.C. (Carel), Amirault, J.D. (J. David), Broderick, J.S. (J. Scott), Snellen, J.P. (Jaap P.), Zijl, J.A.C. (Jacco A.C.), Ahn, J. (Jaimo), Ficke, J. (James), Irrgang, J. (James), Powell, J. (James), Ringler, J.R. (James R.), Shaer, J. (James), Monica, J.T. (James T.), Biert, J. (Jan), Bosma, J. (Jan), Brattgjerd, J.E. (Jan Egil), Frölke, J.P.M. (Jan Paul), Wille, J.C. (Jan), Rajakumar, J. (Janakiraman), Walker, J.E. (Jane E.), Baker, J.K. (Janell K.), Ertl, J.P. (Janos P.), de Vries, J.P.P.M. (Jean Paul P.M.), Gardeniers, J.W.M. (Jean W.M.), May, J. (Jedediah), Yach, J. (Jeff), Hidy, J.T. (Jennifer T.), Westberg, J.R. (Jerald R.), Hall, J.A. (Jeremy A.), van Mulken, J. (Jeroen), McBeth, J.C. (Jessica Cooper), Hoogendoorn, J. (Jochem), Hoffman, J.M. (Jodi M.), Cherian, J.J. (Joe Joseph), Tanksley, J.A. (John A.), Clarke-Jenssen, J. (John), Adams, J.D. (John D.), Esterhai, J. (John), Tilzey, J.F. (John F.), Murnaghan, J. (John), Ketz, J.P. (John P.), Garfi, J.S. (John S.), Schwappach, J. (John), Gorczyca, J.T. (John T.), Wyrick, J. (John), Rydinge, J. (Jonas), Foret, J.L. (Jonathan L.), Gross, J.M. (Jonathan M.), Keeve, J.P. (Jonathan P.), Meijer, J. (Joost), Scheepers, J.J. (Joris J.), Baele, J. (Joseph), O'Neil, J. (Joseph), Cass, J.R. (Joseph R.), Hsu, J.R. (Joseph R.), Dumais, J. (Jules), Lee, J. (Julia), Switzer, J.A. (Julie A.), Agel, J. (Julie), Richards, J.E. (Justin E.), Langan, J.W. (Justin W.), Turckan, K. (Kahn), Pecorella, K. (Kaili), Rai, K. (Kamal), Aurang, K. (Kamran), Shively, K. (Karl), Wessem, K.J.P. van, Moon, K. (Karyn), Eke, K. (Kate), Erwin, K. (Katie), Milner, K. (Katrine), Ponsen, K.J. (Kees-jan), Mills, K. (Kelli), Apostle, K. (Kelly), Johnston, K. (Kelly), Trask, K. (Kelly), Strohecker, K. (Kent), Stringfellow, K. (Kenya), Kruse, K.K. (Kevin K.), Tetsworth, K. (Kevin), Mitchell, K. (Khalis), Browner, K. (Kieran), Hemlock, K. (Kim), Carcary, K. (Kimberly), Jørgen Haug, K. (Knut), Noble, K. (Krista), Robbins, K. (Kristin), Payton, K. (Krystal), Jeray, K.J. (Kyle J.), Rubino, L.J. (L. Joseph), Nastoff, L.A. (Lauren A.), Leffler, L.C. (Lauren C.), Stassen, L.P. (Laurents), O'Malley, L.K. (Lawrence K.), Specht, L.M. (Lawrence M.), Thabane, L. (Lehana), Geeraedts, L.M.G. (Leo M.G.), Shell, L.E. (Leslie E.), Anderson, L.K. (Linda K.), Eickhoff, L.S. (Linda S.), Lyle, L. (Lindsey), Pilling, L. (Lindsey), Buckingham, L. (Lisa), Cannada, L.K. (Lisa K.), Wild, L.M. (Lisa M.), Dulaney-Cripe, L. (Liz), Poelhekke, L.M.S.J., Govaert, L. (Lonneke), Ton, L. (Lu), Kottam, L. (Lucksy), Leenen, L.P.H. (Luke), Clipper, L. (Lydia), Jackson, L.T. (Lyle T.), Hampton, L. (Lynne), de Waal Malefijt, M.C. (Maarten C.), Simons, M.P., Elst, M. (Maarten) van der, Bronkhorst, M.W.G.A. (Maarten), Bhatia, M. (Mahesh), Swiontkowski, M.F. (Marc ), Lobo, M.J. (Margaret J.), Swinton, M. (Marilyn), Pirpiris, M. (Marinis), Molund, M. (Marius), Gichuru, M. (Mark), Glazebrook, M. (Mark), Harrison, M. (Mark), Jenkins, M. (Mark), MacLeod, M. (Mark), Vries, M.R. (Mark) de, Butler, M.S. (Mark S.), Nousiainen, M. (Markku), van ‘t Riet, M. (Martijne), Tynan, M.C. (Martin C.), Campo, M. (Martin), Eversdijk, M.G. (Martin), Heetveld, M.J. (Martin), Richardson, M. (Martin), Breslin, M. (Mary), Fan, M. (Mary), Edison, M. (Matt), Napierala, M. (Matthew), Knobe, M. (Matthias), Russ, M. (Matthias), Zomar, M. (Mauri), de Brauw, M. (Maurits), Esser, M. (Max), Hurley, M. (Meghan), Peters, M.E. (Melissa E.), Lorenzo, M. (Melissa), Li, M. (Mengnai), Archdeacon, M. (Michael), Biddulph, M. (Michael), Charlton, M. (Michael), McDonald, M.D. (Michael D.), McKee, M.D. (Michael D.), Dunbar, M. (Michael), Torchia, M.E. (Michael E.), Gross, M. (Michael), Hewitt, M. (Michael), Holt, M. (Michael), Prayson, M.J. (Michael J.), Edwards, M.J.R. (Michael), Beckish, M.L. (Michael L.), Brennan, M.L. (Michael L.), Dohm, M.P. (Michael P.), Kain, M.S.H. (Michael S.H.), Vogt, M. (Michelle), Yu, M. (Michelle), Verhofstad, M.H.J. (Michiel), Segers, M.J.M. (Michiel J.M.), Segers, M.J.M. (Michiel), Siroen, M.P.C. (Michiel P.C.), Reed, M.R. (Mike), Vicente, M.R. (Milena R.), Bruijninckx, M.M.M. (Milko), Trivedi, M. (Mittal), Bhandari, M. (Mohit), Moore, M.M. (Molly M.), Kunz, M. (Monica), Smedsrud, M. (Morten), Palla, N. (Naveen), Jain, N. (Neeraj), Out, N.J.M. (Nico J.M.), Simunovic, N. (Nicole), Schep, N.W.L. (Niels), Müller, O. (Oliver), Guicherit, O.R. (Onno R.), Waes, O.J.F. (Oscar) van, Wang, O. (Otis), Doornebosch, P. (Pascal), Seuffert, P. (Patricia), Hesketh, P.J. (Patrick J.), Weinrauch, P. (Patrick), Duffy, P. (Paul), Keller, P. (Paul), Lafferty, P.M. (Paul M.), Pincus, P. (Paul), Tornetta III, P. (Paul), Zalzal, P. (Paul), McKay, P. (Paula), Cole, P.A. (Peter A.), de Rooij, P.D. (Peter D.), Hull, P. (Peter), Go, P.M.N.Y.M. (Peter M.N.Y.M.), Patka, P. (Peter), Siska, P. (Peter), Weingarten, P. (Peter), Kregor, P. (Philip), Stahel, P. (Philip), Stull, P. (Philip), Wittich, P. (Philippe), Rijcke, P.A.R. (Piet), Oprel, P.P. (Pim), Devereaux, P.J. (P. J.), Zhou, Q. (Qi), Lee Murphy, R. (R.), Alosky, R. (Rachel), Clarkson, R. (Rachel), Moon, R. (Raely), Logishetty, R. (Rajanikanth), Nanda, R. (Rajesh), Sullivan, R.J. (Raymond J.), Snider, R.G. (Rebecca G.), Buckley, R.E. (Richard E.), Iorio, R. (Richard), Farrugia, R.J. (Richard J), Jenkinson, R. (Richard), Laughlin, R. (Richard), Groenendijk, R.P.R. (Richard), Gurich, R.W. (Richard W.), Worman, R. (Ripley), Silvis, R. (Rob), Haverlag, R. (Robert), Teasdall, R.J. (Robert J.), Korley, R. (Robert), McCormack, R. (Robert), Probe, R. (Robert), Cantu, R.V. (Robert V.), Huff, R.B. (Roger B.), Simmermacher, R.K.J., Peters, R. (Rolf), Pfeifer, R. (Roman), Liem, R. (Ronald), Wessel, R.N. (Ronald N.), Verhagen, R. (Ronald), Vuylsteke, R. (Ronald), Leighton, R. (Ross), McKercher, R. (Ross), Poolman, R.W. (Rudolf), Miller, R. (Russell), Bicknell, R. (Ryan), Finnan, R. (Ryan), Khan, R.M. (Ryan M.), Mehta, S. (Samir), Vang, S. (Sandy), Singh, S. (Sanjay), Anand, S. (Sanjeev), Anderson, S.A. (Sarah A.), Dawson, S.A. (Sarah A.), Marston, S.B. (Scott B.), Porter, S.E. (Scott E.), Watson, S.T. (Scott T.), Festen, S. (Sebastiaan), Lieberman, S. (Shane), Puloski, S. (Shannon), Bielby, S.A. (Shea A.), Sprague, S. (Sheila), Hess, S. (Shelley), MacDonald, S. (Shelley), Evans, S. (Simone), Bzovsky, S. (Sofia), Hasselund, S. (Sondre), Lewis, S. (Sophie), Ugland, S. (Stein), Caminiti, S. (Stephanie), Tanner, S.L. (Stephanie L.), Zielinski, S.M. (Stephanie), Shepard, S. (Stephanie), Sems, S.A. (Stephen A.), Walter, S.D. (Stephen D.), Doig, S. (Stephen), Finley, S.H. (Stephen H.), Kates, S. (Stephen), Lindenbaum, S. (Stephen), Kingwell, S.P. (Stephen P.), Csongvay, S. (Steve), Papp, S. (Steve), Buijk, S.E. (Steven E.), Rhemrev, S. (Steven), Hollenbeck, S.M. (Steven M.), van Gaalen, S.M. (Steven M.), Yang, S. (Steven), Weinerman, S. (Stuart), Subash, (), Lambert, S. (Sue), Liew, S. (Susan), Meylaerts, S.A.G. (Sven), Blokhuis, T.J. (Taco J.), de Vries Reilingh, T.S. (Tammo S.), Lona, T. (Tarjei), Scott, T. (Taryn), Swenson, T.K. (Teresa K.), Endres, T.J. (Terrence J.), Axelrod, T. (Terry), van Egmond, T. (Teun), Pace, T.B. (Thomas B.), Kibsgård, T. (Thomas), Schaller, T.M. (Thomas M.), Ly, T.V. (Thuan V.), Miller, T.J. (Timothy J.), Weber, T. (Timothy), Le, T. (Toan), Oliver, T.M. (Todd M.), Karsten, T.M. (Thomas), Borch, T. (Tor), Hoseth, T.M. (Tor Magne), Nicolaisen, T. (Tor), Ianssen, T. (Torben), Rutherford, T. (Tori), Nanney, T. (Tracy), Gervais, T. (Trevor), Stone, T. (Trevor), Schrickel, T. (Tyson), Scrabeck, T. (Tyson), Ganguly, U. (Utsav), Naumetz, V. (V.), Frizzell, V. (Valda), Wadey, V. (Veronica), Jones, V. (Vicki), Avram, V. (Victoria), Mishra, V. (Vimlesh), Yadav, V. (Vineet), Arora, V. (Vinod), Tyagi, V. (Vivek), Borsella, V. (Vivian), Willems, W.J. (Jaap), Hoffman, W.H. (W. H.), Gofton, W.T. (Wade T.), Lackey, W.G. (Wesley G.), Ghent, W. (Wesley), Obremskey, W. (William), Oxner, W. (William), Cross, W.W. (William W.), Murtha, Y.M. (Yvonne M.), Murdoch, Z. (Zoe), Nauth, A. (Aaron), Creek, A.T. (Aaron T.), Zellar, A. (Abby), Lawendy, A.-R. (Abdel-Rahman), Dowrick, A. (Adam), Gupta, A. (Ajay), Dadi, A. (Akhil), Kampen, A. (A.) van, Yee, A. (Albert), Vries, A.C. (Alexander) de, de Mol van Otterloo, A. (Alexander), Garibaldi, A. (Alisha), Liew, A. (Allen), McIntyre, A.W. (Allison W.), Prasad, A.S. (Amal Shankar), Romero, A.W. (Amanda W.), Rangan, A. (Amar), Oatt, A. (Amber), Sanghavi, A. (Amir), Foley, A.L. (Amy L.), Karlsten, A. (Anders), Dolenc, A. (Andrea), Bucknill, A. (Andrew), Chia, A. (Andrew), Evans, A. (Andrew), Gong, A. (Andrew), Schmidt, A.H. (Andrew H.), Marcantonio, A.J. (Andrew J.), Jennings, A. (Andrew), Ward, A. (Angela), Khanna, A. (Angshuman), Rai, A. (Anil), Smits, A.B. (Anke B.), Horan, A.D. (Annamarie D.), Brekke, A.C. (Anne Christine), Flynn, A. (Annette), Duraikannan, A. (Aravin), Stødle, A. (Are), van Vugt, A.B. (Arie B.), Luther, A. (Arlene), Zurcher, A.W. (Arthur W.), Jain, A. (Arvind), Amundsen, A. (Asgeir), Moaveni, A. (Ash), Carr, A. (Ashley), Sharma, A. (Ateet), Hill, A.D. (Austin D.), Trommer, A. (Axel), Rai, B.S. (B. 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(Graham), Etherington, G. (Greg), Rocca, G.J.D. (Gregory J. Della), Ekås, G. (Guri), Dobbin, G. (Gwendolyn), Lemke, H.M. (H. Michael), Curry, H. (Hamish), Boxma, H. (Han), Gissel, H. (Hannah), Kreder, H. (Hans), Kuiken, H. (Hans), Brom, H.L.F., Pape, H.-C. (Hans-Christoph), Vis, H.M. (Harm) van der, Bedi, H. (Harvinder), Vallier, H.A. (Heather A.), Brien, H. (Heather), Silva, H. (Heather), Newman, H. (Heike), Viveiros, H. (Helena), van der Hoeven, H. (Henk), Ahn, H. (Henry), Johal, H. (Herman), Rijna, H., Stockmann, H. (Heyn), Josaputra, H.A. (Hong A.), Carlisle, H. (Hope), van der Brand, I. (Igor), Dawson, I. (Imro), Tarkin, I. (Ivan), Wong, I. (Ivan), Parr, J.A. (J. Andrew), Trenholm, J.A. (J. Andrew), Goslings, J.C. (Carel), Amirault, J.D. (J. David), Broderick, J.S. (J. Scott), Snellen, J.P. (Jaap P.), Zijl, J.A.C. (Jacco A.C.), Ahn, J. (Jaimo), Ficke, J. (James), Irrgang, J. (James), Powell, J. (James), Ringler, J.R. (James R.), Shaer, J. (James), Monica, J.T. (James T.), Biert, J. (Jan), Bosma, J. (Jan), Brattgjerd, J.E. (Jan Egil), Frölke, J.P.M. (Jan Paul), Wille, J.C. (Jan), Rajakumar, J. (Janakiraman), Walker, J.E. (Jane E.), Baker, J.K. (Janell K.), Ertl, J.P. (Janos P.), de Vries, J.P.P.M. (Jean Paul P.M.), Gardeniers, J.W.M. (Jean W.M.), May, J. (Jedediah), Yach, J. (Jeff), Hidy, J.T. (Jennifer T.), Westberg, J.R. (Jerald R.), Hall, J.A. (Jeremy A.), van Mulken, J. (Jeroen), McBeth, J.C. (Jessica Cooper), Hoogendoorn, J. (Jochem), Hoffman, J.M. (Jodi M.), Cherian, J.J. (Joe Joseph), Tanksley, J.A. (John A.), Clarke-Jenssen, J. (John), Adams, J.D. (John D.), Esterhai, J. (John), Tilzey, J.F. (John F.), Murnaghan, J. (John), Ketz, J.P. (John P.), Garfi, J.S. (John S.), Schwappach, J. (John), Gorczyca, J.T. (John T.), Wyrick, J. (John), Rydinge, J. (Jonas), Foret, J.L. (Jonathan L.), Gross, J.M. (Jonathan M.), Keeve, J.P. (Jonathan P.), Meijer, J. (Joost), Scheepers, J.J. (Joris J.), Baele, J. (Joseph), O'Neil, J. (Joseph), Cass, J.R. (Joseph R.), Hsu, J.R. (Joseph R.), Dumais, J. (Jules), Lee, J. (Julia), Switzer, J.A. (Julie A.), Agel, J. (Julie), Richards, J.E. (Justin E.), Langan, J.W. (Justin W.), Turckan, K. (Kahn), Pecorella, K. (Kaili), Rai, K. (Kamal), Aurang, K. (Kamran), Shively, K. (Karl), Wessem, K.J.P. van, Moon, K. (Karyn), Eke, K. (Kate), Erwin, K. (Katie), Milner, K. (Katrine), Ponsen, K.J. (Kees-jan), Mills, K. (Kelli), Apostle, K. (Kelly), Johnston, K. (Kelly), Trask, K. (Kelly), Strohecker, K. (Kent), Stringfellow, K. (Kenya), Kruse, K.K. (Kevin K.), Tetsworth, K. (Kevin), Mitchell, K. (Khalis), Browner, K. (Kieran), Hemlock, K. (Kim), Carcary, K. (Kimberly), Jørgen Haug, K. (Knut), Noble, K. (Krista), Robbins, K. (Kristin), Payton, K. (Krystal), Jeray, K.J. (Kyle J.), Rubino, L.J. (L. Joseph), Nastoff, L.A. (Lauren A.), Leffler, L.C. (Lauren C.), Stassen, L.P. (Laurents), O'Malley, L.K. (Lawrence K.), Specht, L.M. (Lawrence M.), Thabane, L. (Lehana), Geeraedts, L.M.G. (Leo M.G.), Shell, L.E. (Leslie E.), Anderson, L.K. (Linda K.), Eickhoff, L.S. (Linda S.), Lyle, L. (Lindsey), Pilling, L. (Lindsey), Buckingham, L. (Lisa), Cannada, L.K. (Lisa K.), Wild, L.M. (Lisa M.), Dulaney-Cripe, L. (Liz), Poelhekke, L.M.S.J., Govaert, L. (Lonneke), Ton, L. (Lu), Kottam, L. (Lucksy), Leenen, L.P.H. (Luke), Clipper, L. (Lydia), Jackson, L.T. (Lyle T.), Hampton, L. (Lynne), de Waal Malefijt, M.C. (Maarten C.), Simons, M.P., Elst, M. (Maarten) van der, Bronkhorst, M.W.G.A. (Maarten), Bhatia, M. (Mahesh), Swiontkowski, M.F. (Marc ), Lobo, M.J. (Margaret J.), Swinton, M. (Marilyn), Pirpiris, M. (Marinis), Molund, M. (Marius), Gichuru, M. (Mark), Glazebrook, M. (Mark), Harrison, M. (Mark), Jenkins, M. (Mark), MacLeod, M. (Mark), Vries, M.R. (Mark) de, Butler, M.S. (Mark S.), Nousiainen, M. (Markku), van ‘t Riet, M. (Martijne), Tynan, M.C. (Martin C.), Campo, M. (Martin), Eversdijk, M.G. (Martin), Heetveld, M.J. (Martin), Richardson, M. (Martin), Breslin, M. (Mary), Fan, M. (Mary), Edison, M. (Matt), Napierala, M. (Matthew), Knobe, M. (Matthias), Russ, M. (Matthias), Zomar, M. (Mauri), de Brauw, M. (Maurits), Esser, M. (Max), Hurley, M. (Meghan), Peters, M.E. (Melissa E.), Lorenzo, M. (Melissa), Li, M. (Mengnai), Archdeacon, M. (Michael), Biddulph, M. (Michael), Charlton, M. (Michael), McDonald, M.D. (Michael D.), McKee, M.D. (Michael D.), Dunbar, M. (Michael), Torchia, M.E. (Michael E.), Gross, M. (Michael), Hewitt, M. (Michael), Holt, M. (Michael), Prayson, M.J. (Michael J.), Edwards, M.J.R. (Michael), Beckish, M.L. (Michael L.), Brennan, M.L. (Michael L.), Dohm, M.P. (Michael P.), Kain, M.S.H. (Michael S.H.), Vogt, M. (Michelle), Yu, M. (Michelle), Verhofstad, M.H.J. (Michiel), Segers, M.J.M. (Michiel J.M.), Segers, M.J.M. (Michiel), Siroen, M.P.C. (Michiel P.C.), Reed, M.R. (Mike), Vicente, M.R. (Milena R.), Bruijninckx, M.M.M. (Milko), Trivedi, M. (Mittal), Bhandari, M. (Mohit), Moore, M.M. (Molly M.), Kunz, M. (Monica), Smedsrud, M. (Morten), Palla, N. (Naveen), Jain, N. (Neeraj), Out, N.J.M. (Nico J.M.), Simunovic, N. (Nicole), Schep, N.W.L. (Niels), Müller, O. (Oliver), Guicherit, O.R. (Onno R.), Waes, O.J.F. (Oscar) van, Wang, O. (Otis), Doornebosch, P. (Pascal), Seuffert, P. (Patricia), Hesketh, P.J. (Patrick J.), Weinrauch, P. (Patrick), Duffy, P. (Paul), Keller, P. (Paul), Lafferty, P.M. (Paul M.), Pincus, P. (Paul), Tornetta III, P. (Paul), Zalzal, P. (Paul), McKay, P. (Paula), Cole, P.A. (Peter A.), de Rooij, P.D. (Peter D.), Hull, P. (Peter), Go, P.M.N.Y.M. (Peter M.N.Y.M.), Patka, P. (Peter), Siska, P. (Peter), Weingarten, P. (Peter), Kregor, P. (Philip), Stahel, P. (Philip), Stull, P. (Philip), Wittich, P. (Philippe), Rijcke, P.A.R. (Piet), Oprel, P.P. (Pim), Devereaux, P.J. (P. J.), Zhou, Q. (Qi), Lee Murphy, R. (R.), Alosky, R. (Rachel), Clarkson, R. (Rachel), Moon, R. (Raely), Logishetty, R. (Rajanikanth), Nanda, R. (Rajesh), Sullivan, R.J. (Raymond J.), Snider, R.G. (Rebecca G.), Buckley, R.E. (Richard E.), Iorio, R. (Richard), Farrugia, R.J. (Richard J), Jenkinson, R. (Richard), Laughlin, R. (Richard), Groenendijk, R.P.R. (Richard), Gurich, R.W. (Richard W.), Worman, R. (Ripley), Silvis, R. (Rob), Haverlag, R. (Robert), Teasdall, R.J. (Robert J.), Korley, R. (Robert), McCormack, R. (Robert), Probe, R. (Robert), Cantu, R.V. (Robert V.), Huff, R.B. (Roger B.), Simmermacher, R.K.J., Peters, R. (Rolf), Pfeifer, R. (Roman), Liem, R. (Ronald), Wessel, R.N. (Ronald N.), Verhagen, R. (Ronald), Vuylsteke, R. (Ronald), Leighton, R. (Ross), McKercher, R. (Ross), Poolman, R.W. (Rudolf), Miller, R. (Russell), Bicknell, R. (Ryan), Finnan, R. (Ryan), Khan, R.M. (Ryan M.), Mehta, S. (Samir), Vang, S. (Sandy), Singh, S. (Sanjay), Anand, S. (Sanjeev), Anderson, S.A. (Sarah A.), Dawson, S.A. (Sarah A.), Marston, S.B. (Scott B.), Porter, S.E. (Scott E.), Watson, S.T. (Scott T.), Festen, S. (Sebastiaan), Lieberman, S. (Shane), Puloski, S. (Shannon), Bielby, S.A. (Shea A.), Sprague, S. (Sheila), Hess, S. (Shelley), MacDonald, S. (Shelley), Evans, S. (Simone), Bzovsky, S. (Sofia), Hasselund, S. (Sondre), Lewis, S. (Sophie), Ugland, S. (Stein), Caminiti, S. (Stephanie), Tanner, S.L. (Stephanie L.), Zielinski, S.M. (Stephanie), Shepard, S. (Stephanie), Sems, S.A. (Stephen A.), Walter, S.D. (Stephen D.), Doig, S. (Stephen), Finley, S.H. (Stephen H.), Kates, S. (Stephen), Lindenbaum, S. (Stephen), Kingwell, S.P. (Stephen P.), Csongvay, S. (Steve), Papp, S. (Steve), Buijk, S.E. (Steven E.), Rhemrev, S. (Steven), Hollenbeck, S.M. (Steven M.), van Gaalen, S.M. (Steven M.), Yang, S. (Steven), Weinerman, S. (Stuart), Subash, (), Lambert, S. (Sue), Liew, S. (Susan), Meylaerts, S.A.G. (Sven), Blokhuis, T.J. (Taco J.), de Vries Reilingh, T.S. (Tammo S.), Lona, T. (Tarjei), Scott, T. (Taryn), Swenson, T.K. (Teresa K.), Endres, T.J. (Terrence J.), Axelrod, T. (Terry), van Egmond, T. (Teun), Pace, T.B. (Thomas B.), Kibsgård, T. (Thomas), Schaller, T.M. (Thomas M.), Ly, T.V. (Thuan V.), Miller, T.J. (Timothy J.), Weber, T. (Timothy), Le, T. (Toan), Oliver, T.M. (Todd M.), Karsten, T.M. (Thomas), Borch, T. (Tor), Hoseth, T.M. (Tor Magne), Nicolaisen, T. (Tor), Ianssen, T. (Torben), Rutherford, T. (Tori), Nanney, T. (Tracy), Gervais, T. (Trevor), Stone, T. (Trevor), Schrickel, T. (Tyson), Scrabeck, T. (Tyson), Ganguly, U. (Utsav), Naumetz, V. (V.), Frizzell, V. (Valda), Wadey, V. (Veronica), Jones, V. (Vicki), Avram, V. (Victoria), Mishra, V. (Vimlesh), Yadav, V. (Vineet), Arora, V. (Vinod), Tyagi, V. (Vivek), Borsella, V. (Vivian), Willems, W.J. (Jaap), Hoffman, W.H. (W. H.), Gofton, W.T. (Wade T.), Lackey, W.G. (Wesley G.), Ghent, W. (Wesley), Obremskey, W. (William), Oxner, W. (William), Cross, W.W. (William W.), Murtha, Y.M. (Yvonne M.), and Murdoch, Z. (Zoe)

Abstract

Background Reoperation rates are high after surgery for hip fractures. We investigated the effect of a sliding hip screw versus cancellous screws on the risk of reoperation and other key outcomes. Methods For this international, multicentre, allocation concealed randomised controlled trial, we enrolled patients aged 50 years or older with a low-energy hip fracture requiring fracture fixation from 81 clinical centres in eight countries. Patients were assigned by minimisation with a centralised computer system to receive a single large-diameter screw with a side-plate (sliding hip screw) or the present standard of care, multiple small-diameter cancellous screws. Surgeons and patients were not blinded but the data analyst, while doing the analyses, remained blinded to treatment groups. The primary outcome was hip reoperation within 24 months after initial surgery to promote fracture healing, relieve pain, treat infection, or improve function. Analyses followed the intention-to-treat principle. This study was registered with ClinicalTrials.gov, number NCT00761813. Findings Between Marc

Published
2017
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31. Bias towards dementia: Are hip fracture trials excluding too many patients?

Author

Hebert-Davies, J., Laflamme, G.Y., Rouleau, D., Schreurs, B.W., Kampen, A. van, Biert, J., Vugt, A.B. van, Edwards, M.J.R., Blokhuis, T.J., Frolke, J.P.M., Geeraidts, L., Gardeniers, J.W.M., Tan, E.C.T.H., Poekhekke, L.M.S.J., Waal Malefijt, M.C. de, Emergency Medicine, Surgery, and Radiology & Nuclear Medicine

Subjects
Male, Canada, medicine.medical_specialty, MEDLINE, India, Poison control, Comorbidity, Arthroscopy, Quality of life, Surveys and Questionnaires, Injury prevention, medicine, Humans, Dementia, Cognitive Dysfunction, Geriatric Assessment, Selection Bias, Aged, Netherlands, General Environmental Science, Aged, 80 and over, Geriatrics, Human Movement & Fatigue [NCEBP 10], Clinical Trials as Topic, Hip fracture, Hip Fractures, Norway, business.industry, Patient Selection, Australia, medicine.disease, United States, Human Movement & Fatigue Tissue engineering and pathology [NCEBP 10], Evaluation of complex medical interventions [NCEBP 2], Quality of Life, Physical therapy, General Earth and Planetary Sciences, Female, Evaluation of complex medical interventions Tissue engineering and pathology [NCEBP 2], business, Prejudice
Abstract

Patients with hip fractures are older and often present many co-morbidities, including dementia.These patients cannot answer quality of life questionnaires and are generally excluded from trials.We hypothesized that a significant number of patients are being excluded from these studies and thismay impact outcomes. This was a two part study; the first analyzing databases of two ongoing large-scale multi-centred hip fracture trials and the second being a systematic review. The FAITH andHEALTH studies were analyzed for exclusion incidence directly related to dementia. The second partconsisted of a systematic search of all relevant studies within the last 20 years. In the FAITH study, atotal of 1690 subjects were excluded, 375 (22.2%) of which were due to dementia or cognitiveimpairment. In the HEALTH study, 575 were excluded with dementia/cognitive impairmentrepresenting 207 patients (36%). Following the systematic review, 251 articles were identified 17 ofwhich were retained. The overall prevalence of dementia was 27.9% (range 2–51%). Only two studiescompared demented and non-demented groups. In these studies significant increases in bothmortality and complications were found. In summary, when investigating hip fractures, choosingappropriate objective endpoints is essential to ensure results are also applicable to patients withdementia.

Published
2012
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32. Implant Removal After Internal Fixation of a Femoral Neck Fracture: Effects on Physical Functioning

Author

Zielinski, S.M., Heetveld, M.J., Bhandari, M., Patka, P., Lieshout, E.M. van, Kampen, A. van, Biert, J., Edwards, M.J., Blokhuis, T.J., Frolke, J.P.M., Geeraedts, L.M.G., Gardeniers, J.W., Tan, E.C.T.H., Poelhekke, L.M.S.J., Waal Malefijt, M.C. de, Schreurs, B.W., Emergency Medicine, and Surgery

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Osteoarthritis, Motor Activity, law.invention, Cohort Studies, Fracture Fixation, Internal, Randomized controlled trial, law, Risk Factors, Fracture fixation, Activities of Daily Living, medicine, Prevalence, Internal fixation, Humans, Orthopedics and Sports Medicine, Device Removal, Femoral neck, Aged, Netherlands, Hip fracture, business.industry, General Medicine, Middle Aged, medicine.disease, Arthralgia, Internal Fixators, 3. Good health, Surgery, Femoral Neck Fractures, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], medicine.anatomical_structure, Treatment Outcome, Ambulatory, Quality of Life, Female, Implant, business
Abstract

Item does not contain fulltext OBJECTIVES: The effect of implant removal after internal fixation of a femoral neck fracture on physical functioning was analyzed. Characteristics of patients who had their implant removed were studied, as it is currently unknown from which type of patients implants are removed and what effect removal has on function. DESIGN: Secondary cohort study alongside a randomized controlled trial. SETTING: Multicenter study in 14 hospitals. PATIENTS AND INTERVENTION: Patients who had their implant removed after internal fixation of a femoral neck fracture are compared with patients who did not. MAIN OUTCOME MEASUREMENTS: Patient characteristics and quality of life (Short Form 12, Western Ontario McMaster Osteoarthritis Index) were compared. Matched pairs were selected based on patient/fracture characteristics and prefracture physical functioning. RESULTS: Of 162 patients, 37 (23%) had their implant removed. These patients were younger (median age: 67 vs. 72 years, P = 0.024) and more often independently ambulatory prefracture (100% vs. 84%, P = 0.008) than patients who did not. They more often had evident implant back-out on x-rays (54% vs. 34%, P = 0.035), possibly related to a higher rate of Pauwels 3 fractures (41% vs. 22%, P = 0.032). In time, quality of life improved more in implant removal patients [+2 vs. -4 points, Short Form 12 (physical component), P = 0.024; +9 vs. 0 points, Western Ontario McMaster Osteoarthritis Index, P = 0.019]. CONCLUSIONS: Implant removal after internal fixation of a femoral neck fracture positively influenced quality of life. Implant removal patients were younger and more often independently ambulatory prefracture, more often had a Pauwels 3 fracture, and an evident implant back-out. Implant removal should be considered liberally for these patients if pain persists or functional recovery is unsatisfactory. LEVEL OF EVIDENCE: Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.

Published
2015

36. Reliability, validity, and responsiveness of the Western Ontario and McMaster Universities Osteoarthritis Index for elderly patients with a femoral neck fracture

Author

Burgers, P.T., Poolman, R.W., Bakel, T.M. Van, Tuinebreijer, W.E., Zielinski, S.M., Bhandari, M., Patka, P., Lieshout, E.M. van, Kampen, A. van, Biert, J., Vugt, A.B. van, Edwards, M.J.R., Blokhuis, T.J., Frolke, J.P., Geeraedts, L.M.G., Gardeniers, J.W.M., Tan, E.C.T.H., Poelhekke, L.M.S.J., Waal Malefijt, M.C. de, Schreurs, B.W., et al., Burgers, P.T., Poolman, R.W., Bakel, T.M. Van, Tuinebreijer, W.E., Zielinski, S.M., Bhandari, M., Patka, P., Lieshout, E.M. van, Kampen, A. van, Biert, J., Vugt, A.B. van, Edwards, M.J.R., Blokhuis, T.J., Frolke, J.P., Geeraedts, L.M.G., Gardeniers, J.W.M., Tan, E.C.T.H., Poelhekke, L.M.S.J., Waal Malefijt, M.C. de, Schreurs, B.W., and et al.

Abstract

Item does not contain fulltext, BACKGROUND: The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) has been extensively evaluated in groups of patients with osteoarthritis, yet not in patients with a femoral neck fracture. This study aimed to determine the reliability, construct validity, and responsiveness of the WOMAC compared with the Short Form-12 (SF-12) and the EuroQol 5D (EQ-5D) questionnaires for the assessment of elderly patients with a femoral neck fracture. METHODS: Reliability was tested by assessing the Cronbach alpha. Construct validity was determined with the Pearson correlation coefficient. Change scores were calculated from ten weeks to twelve months of follow-up. Standardized response means and floor and ceiling effects were determined. Analyses were performed to compare the results for patients less than eighty years old with those for patients eighty years of age or older. RESULTS: The mean WOMAC total score was 89 points before the fracture in the younger patients and increased from 70 points at ten weeks to 81 points at two years postoperatively. In the older age group, these scores were 86, 75, and 78 points. The mean WOMAC pain scores before the fracture and at ten weeks and two years postoperatively were 92, 76, and 87 points, respectively, in the younger age group and 92, 84, and 93 points in the older age group. Function scores were 89, 68, and 79 points for the younger age group and 84, 71, and 73 points for the older age group. The Cronbach alpha for pain, stiffness, function, and the total scale ranged from 0.83 to 0.98 for the younger age group and from 0.79 to 0.97 for the older age group. Construct validity was good, with 82% and 79% of predefined hypotheses confirmed in the younger and older age groups, respectively. Responsiveness was moderate. No floor effects were found. Moderate to large ceiling effects were found for pain and stiffness scales at ten weeks and twelve months in younger patients (18% to 36%) and in the older age group (38% to

Published
2015

37. Femoral neck shortening after internal fixation of a femoral neck fracture

Author

Zielinski, S.M., Keijsers, N.L.W., Praet, S.F., Heetveld, M.J., Bhandari, M., Wilssens, J.P., Patka, P., Lieshout, E.M. van, Kampen, A. van, Biert, J., Vugt, A.B. van, Edwards, M.J.R., Blokhuis, T.J., Frolke, J.P.M., Geeraedts, L.M.G., Gardeniers, J.W.M., Tan, E.C.T.H., Poelhekke, L.M.S.J., Waal Malefijt, M.C. de, Schreurs, B.W., AMS - Amsterdam Movement Sciences, Surgery, Other departments, Other Research, Rehabilitation Medicine, and Emergency Medicine

Subjects
Joint Instability, Male, medicine.medical_specialty, WOMAC, Heel, medicine.medical_treatment, Isometric exercise, Femoral Neck Fractures, 03 medical and health sciences, Fracture Fixation, Internal, 0302 clinical medicine, Postoperative Complications, Risk Factors, Fracture fixation, medicine, Prevalence, Internal fixation, Humans, Orthopedics and Sports Medicine, 030212 general & internal medicine, Femoral neck, Aged, Netherlands, Human Movement & Fatigue [NCEBP 10], Fracture Healing, 030222 orthopedics, business.industry, Recovery of Function, Middle Aged, Gait, Surgery, Leg Length Inequality, Human Movement & Fatigue Tissue engineering and pathology [NCEBP 10], medicine.anatomical_structure, Treatment Outcome, Evaluation of complex medical interventions [NCEBP 2], Female, Evaluation of complex medical interventions Tissue engineering and pathology [NCEBP 2], business, human activities
Abstract

Item does not contain fulltext This study assesses femoral neck shortening and its effect on gait pattern and muscle strength in patients with femoral neck fractures treated with internal fixation. Seventy-six patients from a multicenter randomized controlled trial participated. Patient characteristics and Short Form 12 and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were collected. Femoral neck shortening, gait parameters, and maximum isometric forces of the hip muscles were measured and differences between the fractured and contralateral leg were calculated. Variables of patients with little or no shortening, moderate shortening, and severe shortening were compared using univariate and multivariate analyses. Median femoral neck shortening was 1.1 cm. Subtle changes in gait pattern, reduced gait velocity, and reduced abductor muscle strength were observed. Age, weight, and Pauwels classification were risk factors for femoral neck shortening. Femoral neck shortening decreased gait velocity and seemed to impair gait symmetry and physical functioning. In conclusion, internal fixation of femoral neck fractures results in permanent physical limitations. The relatively young and healthy patients in our study seem capable of compensating. Attention should be paid to femoral neck shortening and proper correction with a heel lift, as inadequate correction may cause physical complaints and influence outcome.

Published
2013

38. BMP-7 stimulates early diaphyseal fracture healing in estrogen deficient rats

Author

Blokhuis, T.J., Buma, P., Verdonschot, Nicolaas Jacobus Joseph, Gotthardt, M., Hendriks, T., and Faculty of Engineering Technology

Subjects
Human Movement & Fatigue [NCEBP 10], Tissue engineering and pathology Translational research [NCMLS 3], IR-84995, METIS-293140, Functional imaging [IGMD 1], Tissue engineering and pathology [NCMLS 3]
Abstract

Item does not contain fulltext Estrogen deficiency causes postmenopausal osteoporosis. The relationship between estrogen deficiency and the high failure rate after osteoporotic fracture treatment is unclear, as is the effect of possible interventions, either with anti-resorptive agents or with anabolic agents such as bone morphogenetic proteins (BMPs). To investigate the influence of estrogen deficiency as well as the effect of early intervention, forty female wistar rats underwent ovarectomy (OVX) followed by low calcium diet. Ten rats underwent sham operations, followed by normal diet. After 6 weeks, a closed midshaft femoral fracture was induced. Ten animals received a systemic bisphosphonate injection, 10 injection of BMP-7 in the fracture, and 10 a combination. All then received a normal diet. After 2 weeks healing was evaluated using radiographs, CT, biomechanical testing, and histology. Radiography showed significant increase of bridging in groups treated with BMP-7. Callus volume was higher in these groups. Bending stiffness and strength were similar between OVX and sham, and not influenced by bisphosphonates. Significant increase was seen in groups treated with BMP-7. Histology was in accordance with other endpoints. Early fracture healing was not affected by estrogen deficiency. While no beneficiary effect of bisphosphonate treatment was found, injection of BMP-7 stimulated healing in ovarectomized rats. 01 mei 2012

Published
2012

39. Fixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws on revision surgery rates and quality of life in the treatment of femoral neck fractures.

Author

Kampen, A. van, Biert, J., Vugt, A.B. van, Edwards, M.J.R., Blokhuis, T.J., Frolke, J.P.M., Geeraedts, L.M.G., Gardeniers, J.W.M., Tan, E.C.T.H., Poelhekke, L.M.S.J., Waal Malefijt, M.C. de, Schreurs, B.W., et al., Kampen, A. van, Biert, J., Vugt, A.B. van, Edwards, M.J.R., Blokhuis, T.J., Frolke, J.P.M., Geeraedts, L.M.G., Gardeniers, J.W.M., Tan, E.C.T.H., Poelhekke, L.M.S.J., Waal Malefijt, M.C. de, Schreurs, B.W., and et al.

Abstract

Contains fulltext : 138045.pdf (publisher's version ) (Open Access)

Published
2014

41. Bias towards dementia: are hip fracture trials excluding too many patients? A systematic review

Author

Hebert-Davies, J., Laflamme, G.Y., Rouleau, D., Schreurs, B.W., Kampen, A. van, Biert, J., Vugt, A.B. van, Edwards, M.J.R., Blokhuis, T.J., Frolke, J.P.M., Geeraidts, L., Gardeniers, J.W.M., Tan, E.C.T.H., Poekhekke, L.M.S.J., Waal Malefijt, M.C. de, et al., Hebert-Davies, J., Laflamme, G.Y., Rouleau, D., Schreurs, B.W., Kampen, A. van, Biert, J., Vugt, A.B. van, Edwards, M.J.R., Blokhuis, T.J., Frolke, J.P.M., Geeraidts, L., Gardeniers, J.W.M., Tan, E.C.T.H., Poekhekke, L.M.S.J., Waal Malefijt, M.C. de, and et al.

Abstract

Item does not contain fulltext, Patients with hip fractures are older and often present many co-morbidities, including dementia. These patients cannot answer quality of life questionnaires and are generally excluded from trials. We hypothesized that a significant number of patients are being excluded from these studies and this may impact outcomes. This was a two part study; the first analyzing databases of two ongoing large-scale multi-centred hip fracture trials and the second being a systematic review. The FAITH and HEALTH studies were analyzed for exclusion incidence directly related to dementia. The second part consisted of a systematic search of all relevant studies within the last 20 years. In the FAITH study, a total of 1690 subjects were excluded, 375 (22.2%) of which were due to dementia or cognitive impairment. In the HEALTH study, 575 were excluded with dementia/cognitive impairment representing 207 patients (36%). Following the systematic review, 251 articles were identified 17 of which were retained. The overall prevalence of dementia was 27.9% (range 2-51%). Only two studies compared demented and non-demented groups. In these studies significant increases in both mortality and complications were found. In summary, when investigating hip fractures, choosing appropriate objective endpoints is essential to ensure results are also applicable to patients with dementia.

Published
2012

42. Is radiation superior to indomethacin to prevent heterotopic ossification in acetabular fractures?: a systematic review.

Author

Blokhuis, T.J., Frolke, J.P.M., Blokhuis, T.J., and Frolke, J.P.M.

Abstract

Contains fulltext : 80071.pdf (publisher's version ) (Closed access), Heterotopic ossification is a well-known complication after fixation of an acetabular fracture. Indomethacin and radiation therapy are used as prophylaxis to prevent heterotopic ossification. It is unclear, however, whether either is superior, although this may relate to lack of power in individual studies. To compare the effectiveness of indomethacin with the effectiveness of radiation therapy, we conducted a systematic review in which all published prospective studies were evaluated. We performed a literature search in PubMed, MEDLINE, EMBASE, and the Cochrane Controlled Trial Register. The retrieved studies were analyzed and categorized according to the quality and validity score of Jadad et al. We found five appropriate prospective studies, describing 384 patients. Although the quality of the available studies made a proper meta-analysis inappropriate, the incidence of heterotopic ossification was significantly lower in patients treated with radiation than in patients receiving indomethacin (five of 160 versus 20 of 224, respectively). Until further information is available, we believe the evidence supports radiation therapy as the preferred method for preventing heterotopic ossification after operative treatment of acetabular fractures. Level of Evidence: Level II, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.

Published
2009

43. Pharmacological agents and impairment of fracture healing: what is the evidence?

Author

Pountos, I., Georgouli, T., Blokhuis, T.J., Pape, H.C., Giannoudis, P.V., Pountos, I., Georgouli, T., Blokhuis, T.J., Pape, H.C., and Giannoudis, P.V.

Abstract

Contains fulltext : 71494.pdf (publisher's version ) (Closed access), Bone healing is an extremely complex process which depends on the coordinated action of several cell lineages on a cascade of biological events, and has always been a major medical concern. The use of several drugs such as corticosteroids, chemotherapeutic agents, non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, anticoagulants and drugs which reduce osteoclastic activity have been shown to affect bone healing. This review article presents our current understanding on this topic, focusing on data illustrating the effect of these drugs on fracture healing and bone regeneration.

Published
2008

47. A Safer Care Pathway from ICU to Home: With wearable & wireless monitoring

Author

Breteler, Martine Josefien Maria, Kalkman, C.J., Dohmen, D.A.J., Blokhuis, T.J., and University Utrecht

Subjects
Telemonitoring, vital signs, wearable monitoring, eHealth, telemedicine, remote monitoring, continuous monitoring, wireless technology
Abstract

Changes in vital signs are often the first sign of patient deterioration and the need for escalation of care. Unfortunately, vital signs are typically recorded not more than every 4-8 hours as the current standard on hospital wards. Early signs of patient deterioration may therefore be easily overlooked. In the past years, wearable sensors for wireless vital signs monitoring have entered the market that could capture patient deterioration sooner. However, for most wearable sensors their validity is unknown. In this thesis, we set out to answer the question whether current wireless sensors are accurate enough to measure vital signs in high-risk patients and whether these sensors can serve as a safety net in day to day care both on a hospital ward and at home in the early days after discharge. To study this, we performed validation studies with a variety of wearable sensors in patients at risk for complications and investigated the feasibility of remotely monitoring surgical patients after hospital discharge in their own home. Most wireless sensors are accurate for heart rate. Respiratory rate is more difficult to measure, but reliable enough to identify abnormal trend patterns before complications are recognized. Remote monitoring of vital signs is well perceived by patients, but it is more difficult to maintain data continuity when patients are monitored at home. Well-functioning technology is only a minor prerequisite for success. Structured contact moments between patients and clinicians, in addition to remote vital signs monitoring functionality, increases the likelihood of successful implementation of remote patient monitoring. If applied well, this development can truly contribute to delivering the right care in the right place.

Published
2021

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