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1. Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Author

Pei, J., Schuldt, M., Nagyova, E., Gu, Z., el Bouhaddani, S., Yiangou, L., Jansen, M., Calis, J. J. A., Dorsch, L. M., Blok, C. Snijders, van den Dungen, N. A. M., Lansu, N., Boukens, B. J., Efimov, I. R., Michels, M., Verhaar, M. C., de Weger, R., Vink, A., van Steenbeek, F. G., Baas, A. F., Davis, R. P., Uh, H. W., Kuster, D. W. D., Cheng, C., Mokry, M., van der Velden, J., Asselbergs, F. W., and Harakalova, M.

Published
2021
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3. Samenvattingen werkgroep Bodempathogenen

Author

Peters, R., Brinkman, E.P., Kurm, V., Visser, J.H.M., Korthals, G.W., Meisner, A., Streminska, M.A., Blok, C., van Ruijven, J.P.M., van der Salm, C., Peters, R., Brinkman, E.P., Kurm, V., Visser, J.H.M., Korthals, G.W., Meisner, A., Streminska, M.A., Blok, C., van Ruijven, J.P.M., and van der Salm, C.

Published
2023

5. Measuring Platinum Levels in Hair in Women with Silicone Breast Implants and Systemic Symptoms

Author

Spit, K. A., Azahaf, S., de Blok, C. J. M., Nanayakkara, P. W. B., Internal medicine, APH - Quality of Care, APH - Personalized Medicine, APH - Digital Health, and ACS - Diabetes & metabolism

Abstract

Background: It has been suggested that compounds present in silicone breast implants (eg, silicone particles or heavy metals such as platinum) migrate into the body and can cause systemic symptoms in susceptible women, causing what is known as breast implant illness. This pilot study investigates possible associations between hair platinum levels in patients with breast implants and breast implant illness, and evaluates its possible use for diagnostic purposes. Methods: Patients were included from the silicone outpatient clinic at Amsterdam University Medical Centre. Platinum concentration in hair samples of 10 women with breast implants and systemic symptoms (group A) was compared with that in 10 women with breast implants but no symptoms (group B), and a control group of 10 women without implants or symptoms (group C), using laser ablation inductively coupled plasma mass spectrometry. Radiological imaging was used to assess implant ruptures or silicone leakage. Results: A median platinum concentration of 0.09 μg per kg [IQR 0.04-0.15] was found in group A, 0.08 μg per kg [IQR 0.04-0.12] in group B, and 0.04 μg per kg [IQR 0.02-0.13] in group C, with no statistical significant difference between the groups (Kruskal-Wallis test, P = 0.43). No correlation between radiologically proven implant leakage and platinum level was found. Conclusions: There was no statistically significant difference in hair platinum levels in women with or without silicone breast implants or breast implant illness. Therefore, based on this pilot study, we do not recommend this test for clinical use. Given the small sample size, more research is required to fully assess its possible use for diagnostic purposes.

Published
2022

7. Opname van water en voedingsstoffen gaat niet gelijk op : Doordachte voedingssamenstelling kan energie besparen

Author

Lugt, G. van der, Blok, C., Barbagli, T., Heuvelink, E., Kierkels, T., Lugt, G. van der, Blok, C., Barbagli, T., Heuvelink, E., and Kierkels, T.

Abstract

Voor een goede groei en productie moet het gewas voldoende water en voeding opnemen. Die processen zijn maar ten dele gekoppeld. De wateropname is volledig passief. De voedingsopname is daarentegen grotendeels een actief proces dat energie kost. Meer begrip hiervan leidt tot andere telersbeslissingen over de voedingssamenstelling en de manier van bemesten. Dit is deel 2 van een serie over bemesting.

Published
2022

8. Afwijken van basisbemesting en drain heeft zowel voor- als nadelen : Plant houdt energie over voor productie bij lagere nitraatgift

Author

Barbagli, T., Lugt, G. van der, Blok, C., Heuvelink, E., Kierkels, T., Barbagli, T., Lugt, G. van der, Blok, C., Heuvelink, E., and Kierkels, T.

Abstract

Wat zijn de consequenties als je afwijkt van basisrecepten voor de voeding of een hoger drainpercentage aanhoudt? Bijvoorbeeld als je een deel van het nitraat vervangt door chloor of sulfaat. Of een hoger drainpercentage prefereert dan de standaard 33%. Dit is deel 4 van een serie over bemesting.

Published
2022

9. Latitude-dependant climate changes across the Aptian Oceanic Anoxic Event 1a

Author

Blok, C. N., Ineson, J., Anderskouv, K., Fantasia, A., Sheldon, E., Thibault, N., Jelby, M. E., Adatte, T., Bodin, S., Blok, C. N., Ineson, J., Anderskouv, K., Fantasia, A., Sheldon, E., Thibault, N., Jelby, M. E., Adatte, T., and Bodin, S.

Abstract

The understanding of the climatic evolution during the Early Cretaceous in general, and across Oceanic Anoxic Event 1a (OAE-1a) in particular, has generally been derived from Tethyan localities, implying large uncertainties about their significance at a global scale. In this study, high-resolution clay-mineral assemblage analyses have been performed on the Hauterivian to lower Aptian cored section of the North Jens-1 well, located in the Danish Central Graben, North Sea, in the Boreal Realm. Large amounts of detrital kaolinite are observed throughout the core, indicating the presence of a local, kaolinite-rich source. A long-term decline in kaolinite content is recorded from the upper Hauterivian to the lowermost pre-OAE-1a Aptian, followed by a sharp rise within the OAE-1a interval. This trend is similar to that observed in the Tethyan Realm, where a supra-regional climatic evolution is observed, including: (i) relatively humid conditions in the late Hauterivian; (ii) a shift towards overall drier conditions in the latest Barremian – earliest Aptian; and (iii) renewed humid conditions during the unfolding of OAE-1a. However, the precise timing of climate change across OAE-1a differs between the Tethyan and Boreal Realms. The shift towards humid conditions coincides with the onset of OAE-1a (segment C3) in the Tethyan Realm, followed by a return to drier conditions in the second half of the event. In the Boreal Realm, however, the onset of OAE-1a was characterised by a relatively dry climate, followed by an increase in humidity within its middle part (segments C4–C5) that persisted through the remainder of the early Aptian. Consequently, there was a non-linear change in precipitation patterns across latitudinal belts during the unfolding of OAE-1a. Similar conclusions have been drawn for other OAEs, suggesting a more complex weathering feedback mechanism during hyperthermal events than generally assumed.

Published
2022

11. Sturen op voedingsconcentraties in wortelmilieu geeft meeste zekerheid : Bemestingsadviesbasis gebaseerd op honderden onderzoeken

Author

Lugt, G. van der, Blok, C., Voogt, W., Barbagli, T., Heuvelink, E., Kierkels, T., Lugt, G. van der, Blok, C., Voogt, W., Barbagli, T., Heuvelink, E., and Kierkels, T.

Abstract

Dit is het eerste artikel in een serie over optimale bemesting op substraat, rekening houdend met hoe de plant functioneert. Hergebruik van drainwater is gebruikelijk. Dit heeft echter een andere samenstelling dan de standaard voedingsoplossing. Daar moet je bij het mengen rekening mee houden. In alle gevallen is de gewenste samenstelling in het wortelmilieu (de streefwaarden) leidend. Die streefwaarden zijn anders dan de samenstelling van de aangevoerde voedingsoplossing. Er heersen tal van misverstanden op dit gebied die tot verkeerde keuzes kunnen leiden.

Published
2022

21. Let the genes speak! De novo variants in developmental disorders with speech and language impairment

Author

Snijders Blok, C., Brunner, H.G., Fisher, S.E., Kleefstra, T., and Radboud University Nijmegen

Subjects
Language in Interaction, Neurodevelopmental disorders [Radboudumc 7], Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Donders thesis series, Donders Center for Medical Neuroscience
Abstract

Contains fulltext : 236675.pdf (Publisher’s version ) (Open Access) Radboud University, 15 oktober 2021 Promotores : Brunner, H.G., Fisher, S.E., Kleefstra, T. 260 p.

Published
2021

24. Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Author

Pei, J, Schuldt, M, Nagyova, E, Gu, Z, El Bouhaddani, S, Yiangou, L, Jansen, M, Calis, J J A, Dorsch, L M, Blok, C Snijders, van den Dungen, N A M, Lansu, N, Boukens, B J, Efimov, I R, Michels, M, Verhaar, M C, de Weger, R, Vink, A, van Steenbeek, F G, Baas, A F, Davis, R P, Uh, H W, Kuster, D W D, Cheng, C, Mokry, M, van der Velden, J, Asselbergs, F W, Harakalova, M, Pei, J, Schuldt, M, Nagyova, E, Gu, Z, El Bouhaddani, S, Yiangou, L, Jansen, M, Calis, J J A, Dorsch, L M, Blok, C Snijders, van den Dungen, N A M, Lansu, N, Boukens, B J, Efimov, I R, Michels, M, Verhaar, M C, de Weger, R, Vink, A, van Steenbeek, F G, Baas, A F, Davis, R P, Uh, H W, Kuster, D W D, Cheng, C, Mokry, M, van der Velden, J, Asselbergs, F W, and Harakalova, M

Abstract

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most common genetic disease of the cardiac muscle, frequently caused by mutations in MYBPC3. However, little is known about the upstream pathways and key regulators causing the disease. Therefore, we employed a multi-omics approach to study the pathomechanisms underlying HCM comparing patient hearts harboring MYBPC3 mutations to control hearts.RESULTS: Using H3K27ac ChIP-seq and RNA-seq we obtained 9310 differentially acetylated regions and 2033 differentially expressed genes, respectively, between 13 HCM and 10 control hearts. We obtained 441 differentially expressed proteins between 11 HCM and 8 control hearts using proteomics. By integrating multi-omics datasets, we identified a set of DNA regions and genes that differentiate HCM from control hearts and 53 protein-coding genes as the major contributors. This comprehensive analysis consistently points toward altered extracellular matrix formation, muscle contraction, and metabolism. Therefore, we studied enriched transcription factor (TF) binding motifs and identified 9 motif-encoded TFs, including KLF15, ETV4, AR, CLOCK, ETS2, GATA5, MEIS1, RXRA, and ZFX. Selected candidates were examined in stem cell-derived cardiomyocytes with and without mutated MYBPC3. Furthermore, we observed an abundance of acetylation signals and transcripts derived from cardiomyocytes compared to non-myocyte populations.CONCLUSIONS: By integrating histone acetylome, transcriptome, and proteome profiles, we identified major effector genes and protein networks that drive the pathological changes in HCM with mutated MYBPC3. Our work identifies 38 highly affected protein-coding genes as potential plasma HCM biomarkers and 9 TFs as potential upstream regulators of these pathomechanisms that may serve as possible therapeutic targets.

Published
2021

25. Heterozygous variants that disturb the transcriptional repressor activity of FOXP4 cause a developmental disorder with speech/language delays and multiple congenital abnormalities

Author

Snijders Blok, C., Vino, A., Hoed, J. den, Underhill, H.R., Monteil, D., Li, H., Brunner, H.G., Kleefstra, T., Fisher, S.E., Snijders Blok, C., Vino, A., Hoed, J. den, Underhill, H.R., Monteil, D., Li, H., Brunner, H.G., Kleefstra, T., and Fisher, S.E.

Abstract

Contains fulltext : 226774.pdf (publisher's version ) (Open Access), Purpose: Heterozygous pathogenic variants in various FOXP genes cause specific developmental disorders. The phenotype associated with heterozygous variants in FOXP4 has not been previously described. Methods: We assembled a cohort of eight individuals with heterozygous and mostly de novo variants in FOXP4: seven individuals with six different missense variants and one individual with a frameshift variant. We collected clinical data to delineate the phenotypic spectrum, and used in silico analyses and functional cell-based assays to assess pathogenicity of the variants. Results: We collected clinical data for six individuals: five individuals with a missense variant in the forkhead box DNA-binding domain of FOXP4, and one individual with a truncating variant. Overlapping features included speech and language delays, growth abnormalities, congenital diaphragmatic hernia, cervical spine abnormalities, and ptosis. Luciferase assays showed loss-of-function effects for all these variants, and aberrant subcellular localization patterns were seen in a subset. The remaining two missense variants were located outside the functional domains of FOXP4, and showed transcriptional repressor capacities and localization patterns similar to the wild-type protein. Conclusion: Collectively, our findings show that heterozygous loss-of-function variants in FOXP4 are associated with an autosomal dominant neurodevelopmental disorder with speech/language delays, growth defects, and variable congenital abnormalities.

Published
2021

26. Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Author

Afd Pharmacoepi & Clinical Pharmacology, Interne geneeskunde GD, dCSCA AVR, Sub Inorganic Chemistry and Catalysis, LS Vertaalwetenschap, CS_Genetics, Pei, J, Schuldt, M, Nagyova, E, Gu, Z, El Bouhaddani, S, Yiangou, L, Jansen, M, Calis, J J A, Dorsch, L M, Blok, C Snijders, van den Dungen, N A M, Lansu, N, Boukens, B J, Efimov, I R, Michels, M, Verhaar, M C, de Weger, R, Vink, A, van Steenbeek, F G, Baas, A F, Davis, R P, Uh, H W, Kuster, D W D, Cheng, C, Mokry, M, van der Velden, J, Asselbergs, F W, Harakalova, M, Afd Pharmacoepi & Clinical Pharmacology, Interne geneeskunde GD, dCSCA AVR, Sub Inorganic Chemistry and Catalysis, LS Vertaalwetenschap, CS_Genetics, Pei, J, Schuldt, M, Nagyova, E, Gu, Z, El Bouhaddani, S, Yiangou, L, Jansen, M, Calis, J J A, Dorsch, L M, Blok, C Snijders, van den Dungen, N A M, Lansu, N, Boukens, B J, Efimov, I R, Michels, M, Verhaar, M C, de Weger, R, Vink, A, van Steenbeek, F G, Baas, A F, Davis, R P, Uh, H W, Kuster, D W D, Cheng, C, Mokry, M, van der Velden, J, Asselbergs, F W, and Harakalova, M

Published
2021

27. Speech-language profiles in the context of cognitive and adaptive functioning in SATB2-associated syndrome

Author

Snijders Blok, C., Goosen, Y.M., Haaften, L. van, Hulst, C.C.M. van, Fisher, S.E., Brunner, H.G., Egger, J.I.M., Kleefstra, T., Snijders Blok, C., Goosen, Y.M., Haaften, L. van, Hulst, C.C.M. van, Fisher, S.E., Brunner, H.G., Egger, J.I.M., and Kleefstra, T.

Abstract

Contains fulltext : 235059.pdf (Publisher’s version ) (Open Access), SATB2-associated syndrome (SAS) is a neurodevelopmental disorder caused by heterozygous pathogenic variants in the SATB2 gene, and is typically characterized by intellectual disability and severely impaired communication skills. The goal of this study was to contribute to the understanding of speech and language impairments in SAS, in the context of general developmental skills and cognitive and adaptive functioning. We performed detailed oral motor, speech and language profiling in combination with neuropsychological assessments in 23 individuals with a molecularly confirmed SAS diagnosis: 11 primarily verbal individuals and 12 primarily nonverbal individuals, independent of their ages. All individuals had severe receptive language delays. For all verbal individuals, we were able to define underlying speech conditions. While childhood apraxia of speech was most prevalent, oral motor problems appeared frequent as well and were more present in the nonverbal group than in the verbal group. For seven individuals, age-appropriate Wechsler indices could be derived, showing that the level of intellectual functioning of these individuals varied from moderate-mild ID to mild ID-borderline intellectual functioning. Assessments of adaptive functioning with the Vineland Screener showed relatively high scores on the domain 'daily functioning' and relatively low scores on the domain 'communication' in most individuals. Altogether, this study provides a detailed delineation of oral motor, speech and language skills and neuropsychological functioning in individuals with SAS, and can provide families and caregivers with information to guide diagnosis, management and treatment approaches.

Published
2021

29. Wood fiber in pot plant culture; peat replacement up to 50% in volume?

Author

Eveleens, B., van Winkel, A., Blok, C., Eveleens, B., van Winkel, A., and Blok, C.

Abstract

Use of peat and coir in horticulture is under pressure because of the negative effects on the environment. Peat harvesting releases CO2 into the atmosphere and changes the wetland ecosystem. Coir production can cause salt pollution in the country of origin as the product has a high salt level and is washed with fresh water before use as a substrate. HydraFiber, a specific wood fiber product was tested as substitute for (part of) peat and coir in professional potting soils. Wood fiber was mixed in 3 volume percentage ratios (30, 40 and 50% v v-1) with peat or coir. Nutrient content and stability were used to calculate appropriate fertiliser levels for each mixture for growth of a begonia crop in an ebb and flood system. Addition of up to 50% v v-1 wood fiber to peat or coir has no negative effect on the rate of development to flowering of a 10 week crop. The ratio of weight/length of the plants is similar for all treatments. Addition of 40% and 50% v v-1 wood fiber to peat reduces water content by 16% v v-1 and increases air content by the same amount in the substrate in the range of -6 to -100 cm pressure head. Addition of wood fiber to coir has a similar effect. A lower average water content in substrate mixes of peat and wood fiber indicates it is more difficult to overirrigate but that it also requires a more precise monitoring of both, water content and nutrient status. It also requires a higher frequency of irrigation and more frequent adaptations of the nutrient level in the water supply. Using wood fiber in percentages from 30 to 50% v v-1 may also require an adaptation in the growing medium used for propagation plugs.

Published
2021

30. Literatuuronderzoek chrysantenteelt zonder stomen : Kan een monocultuur in een stabiel microbieel evenwicht blijven?

Author

Blok, C., Eveleens, B., de Long, J.R., Raaphorst, M., Messelink, G., Streminska, M., Voogt, W., Kruidhof, M., Fradin, M., Leiss, K.A., van der Salm, C., Blok, C., Eveleens, B., de Long, J.R., Raaphorst, M., Messelink, G., Streminska, M., Voogt, W., Kruidhof, M., Fradin, M., Leiss, K.A., and van der Salm, C.

Abstract

Chrysanthemum are grown in a soil-based cultivation with 4-6 cultivation cycles per year. The build-up of diseases and pests in the soil is considerable. It is now common to steam the soil at least once a year. The related energy consumption is 4-6 m3 gas per m2 per year. The build-up of diseases is associated with hygiene, the cuttings, the press pots on which chrysanthemum cuttings are grown, the transition from propagation to cultivation medium, irrigation cycles and tilling root residues and press pots into the soil after cultivation. Major diseases and pests are Pythium, Fusarium, nematodes and Thrips. This literature study describes what is known about cultivation circumstances promoting diseases and pests. The aim was to assess the feasibility of a chrysanthemum crop without steaming based on adaptations of the current cultivation method., Chrysantenteelt is een grondgebonden teelt met 4-6 teeltcycli per jaar. De opbouw van ziekten en plagen in de bodem is aanzienlijk. Het is nu gebruikelijk de grond minstens eens per jaar te stomen. Het gerelateerde energieverbruik is 4-6 m3 gas per m2 per jaar. De ziektenopbouw wordt in verband gebracht met bedrijfshygiëne, de stekken, de perspotten waarop wordt opgekweekt, de overgang van opkweek naar teeltbodem, de watergiften en het onder frezen van wortelresten en perspotten. De belangrijke ziekten en plagen zijn Pythium, Fusarium, nematoden en Thrips. In dit literatuuronderzoek wordt beschreven wat bekend is over teeltomstandigheden die bevorderlijk zijn voor de ziekten en plagen. Doel was te komen tot een beoordeling van de haalbaarheid van een chrysantenteelt zonder stomen gebaseerd op aanpassingen van de huidige teeltmethode.

Published
2021

31. Growing media for food and quality of life in the period 2020-2050

Author

Blok, C., Eveleens, B., van Winkel, A., Blok, C., Eveleens, B., and van Winkel, A.

Abstract

Growing media in soilless cultivation allow growers to apply water and nutrients more accurate (+15% growth) and to avoid soil diseases (+5/50% growth). Growing media, in combination with recirculation of drainage solution, reduce water use by about 50% and nutrient use by about 60%. For that and other reasons it is expected global growing media use will increase. A more precise estimation of the increase in demand is made, based on the expected growth of the world population, the expected increase in living standards for most people and the influence of several trends. Trends for vegetables include the need to address obesities, chronic micronutrient deficiencies and product safety. Trends for ornamentals include appreciation of natural aesthetics and ameliorating indoor climate and city climate. General trends include dealing with water scarcity, urbanisation, and more. The consequences of the possible higher demand are discussed in view of the availability of common growing media constituents like peat, coir, wood fiber, bark, compost, perlite, stone wool and tuffs as well as for less common but potentially available growing media (constituents) like Sphagnum, water and biochar. The influence of irrigation, drainage and support systems on growing media preference are discussed, as affected by trends, including recirculation of drainage solution, the use of organic fertilisers and developments in remote growing. In conclusion, the global growing media market is highly dynamic with the potential to increase four-fold between 2017 and 2050 with the highest per continent use shifting to Asia. The population increase is expected to contribute about 40%, income increase about 80% and trends about 40% for vegetables and 270% for ornamentals, totalling a market increase of 260% for vegetables and 490% for ornamentals. Growing media can contribute to a more sustainable production of vegetables and ornamentals as well as to public health and quality of life.

Published
2021

32. Recirculation, circular fertilizers and resilience : The potential of growing media systems for circular production

Author

Blok, C., Verkerke, W., Boedijn, A., Streminska, M., Eveleens, B., Blok, C., Verkerke, W., Boedijn, A., Streminska, M., and Eveleens, B.

Abstract

Current thinking about circularity and sustainability is used to identify i) recirculation of drainage water, ii) circular fertilisers, and iii) resilience control as growing media related areas with a wider societal meaning. The objectives are to find to which extent circularity can be realized and how growing media and compost research can serve transition to a more circular horticulture. Recirculation of drainage water increases water use efficiency by 50%, nutrient use efficiency by 60% and eliminates the emission of water borne chemical agents. The challenge remains as still 90% of the global area of growing media systems does not yet use available techniques to realize full recirculation. The global use of more circular fertilisers, including plant, animal and human wastes, can stop depletion of natural reserves and diffuse emission of nutrients. It is argued that the combination of irrigation techniques and the use of growing media offer horticulture both opportunity and reasons to lead in the production of circular fertilisers, being either soluble or slow release. Resilient growing media facilitate cultivation without chemical agents, without disinfection before reuse and without continuous disinfection of recirculating water. We identify methodological improvements still needed to safely progress on this road. The importance of growing media based cultivation is put in perspective of the global production of food and ornamentals.

Published
2021

33. Root oxygen use as a measure for ion uptake from slightly different nutrient solutions

Author

Oud, N., Barbagli, T., Blok, C., Oud, N., Barbagli, T., and Blok, C.

Abstract

The current system of nutrient supply in horticulture may be improved by ion specific measuring in combination with real-time nutrient adjustments. Frequent measurements of the solution around the roots and related adjustments of the solutions supplied, will result in plant roots experiencing smaller fluctuations in nutrient concentrations and ratios than in the current system of analyzing and adjusting the nutrients once in 1-2 weeks. To find out how much effect on growth more frequent measurements and adjustments could have, we measured the oxygen uptake of roots growing in nutrient solutions of different ionic compositions. The assumptions underlying this approach are that nutrient uptake requires energy and the energy is generated by the oxidation of assimilates. Thus root oxygen use is a measure of the energy use for ion uptake and via assimilate use also related to above-ground production. To measure root oxygen use in optimal and slightly sub-optimal nutrient solutions, four air-tight vessels to grow plants in nutrient solutions were constructed. Each vessel was connected to an airbag and a peristaltic pump to circulate the air. Consequently tomato, cucumber and sweet pepper young plants were grown on optimal and slightly sub-optimal nutrient solutions. Oxygen sensors recorded the decrease in oxygen concentration. So far, a 5-18% higher oxygen consumption was found for a NO3 solution as compared to a NO3/Cl solution. In conclusion root oxygen use for a whole root system during growth can be accurately measured and as a first result the uptake of nitrate requires more energy than the uptake of chloride. Consequences for the application of ion specific measurements as well as for the definition of optimised target solutions for the root environment are discussed.

Published
2021

34. Veel onbegrip over humusonderdelen als biostimulanten : Humusdelen stimuleren bodemleven, beschikbaarheid en groei

Author

Blok, C., Heuvelink, E., Kierkels, T., Blok, C., Heuvelink, E., and Kierkels, T.

Abstract

De belangstelling voor biostimulanten groeit en de afzet van humusonderdelen lift daarop mee. Op dit gebied heerst nogal wat begripsverwarring. Niet alleen over de termen, maar ook over het eventuele nut. Alle drie de componenten van humus kunnen positieve effecten hebben. Of het voor glasteelt een toevoeging is, hangt af van de situatie.

Published
2021

35. Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Author

Onderzoek Precision medicine, Other research (not in main researchprogram), Biostatistiek Onderzoek, Genetica Klinische Genetica, Immuno/reuma onderzoek 5 (Vastert2), CMM Groep Cuppen, Unit Opleiding Aios, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, Pathologie Laboratorium diagnostiek, Pathologie Pathologen staf, JC onderzoeksprogramma Methodologie, Onderzoek, Child Health, Team Medisch, Pei, J, Schuldt, M, Nagyova, E, Gu, Z, El Bouhaddani, S, Yiangou, L, Jansen, M, Calis, J J A, Dorsch, L M, Blok, C Snijders, van den Dungen, N A M, Lansu, N, Boukens, B J, Efimov, I R, Michels, M, Verhaar, M C, de Weger, R, Vink, A, van Steenbeek, F G, Baas, A F, Davis, R P, Uh, H W, Kuster, D W D, Cheng, C, Mokry, M, van der Velden, J, Asselbergs, F W, Harakalova, M, Onderzoek Precision medicine, Other research (not in main researchprogram), Biostatistiek Onderzoek, Genetica Klinische Genetica, Immuno/reuma onderzoek 5 (Vastert2), CMM Groep Cuppen, Unit Opleiding Aios, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, Pathologie Laboratorium diagnostiek, Pathologie Pathologen staf, JC onderzoeksprogramma Methodologie, Onderzoek, Child Health, Team Medisch, Pei, J, Schuldt, M, Nagyova, E, Gu, Z, El Bouhaddani, S, Yiangou, L, Jansen, M, Calis, J J A, Dorsch, L M, Blok, C Snijders, van den Dungen, N A M, Lansu, N, Boukens, B J, Efimov, I R, Michels, M, Verhaar, M C, de Weger, R, Vink, A, van Steenbeek, F G, Baas, A F, Davis, R P, Uh, H W, Kuster, D W D, Cheng, C, Mokry, M, van der Velden, J, Asselbergs, F W, and Harakalova, M

Published
2021

38. Acknowledgement to reviewers of social sciences in 2019

Author

Abbas, A., Abel, G., Abreu, A., Adam, A., Adamek, M., Adiletta, G., Adusei-asante, K.A., Romeo, M.D.M., Alderson, A., Alfaro, E., Aliverti, A., Almeida, Fernando, Álvarez-gonzález, L.I., Amelina, A., Anand, C., Anderson, G., Andreasson, J., Ang, I., Aragon, J., Arcidiacono, C., Arcuri, S., Assante, D., Atukeren, E., Avery, H., Ayeb-karlsson, S., Azadi, H., Bachman, R., Bader, M., Badulescu, A., Bahmanteymouri, E., Baines, S., Baker, T., Baker‐beall, C., Bañón, L., Bar‐am, N., Barbier‐greenland, K., Barnett, R., Barragán‐escandón, A., Barreto, A.M., Barrett, E., Bartkowski, J., Bartram, R., Bartzas, G., Bates, D., Baviera‐puig, A., Bayley, A., Beazley, H., Beer, C., Behr, H., Beier, G., Belford, N., Bencivenga, R., Benli, A.E., Benton‐short, L., Berei, J.M., Berbel‐pineda, E., Bernstein, Berntzen, E.R., Bertella, L., Birney, G., Bittle, M., Black, S., Rivero, L.B., Blattner, J.J., Blok, C., Blount, A., Boas, Y., Bockarie, I., Bockerman, A., Bodén, P., Bönisch‐brednich, L., Bontje, B., Bontje, M., Borsellino, V., Bostan, I., Bowl, M., Bowman, B., Bracci, E., Bracken, C.M., Bradley, H., Brereton, P., Brewer, J., Bridge, D., Brooks, S., Brown, Andrijana, Brzoska, M., Brzozowski, W., Buckley, G., Buente, W., Bullaro, G.R., Burke, M.D., Burlacu, S., Busu, M., Butler, S., Byrne, J., Cabral, L., Cai, Y., Cajias, M., Calin, A.C., Callegari, C., Camarero, M., Campbell-figuerola, H., Campbell, J.R., Cannito, M., Canonico, E., Canosa, A., Carabelli, G., Carlbom, A., Carlone, T., Caron, R., Carpenter, A., Caruso, G., Casais, B., Castro, M.P., Cava, M.-J., Čeněk, J., Cerchione, R., Certomà, C., Chan, E., Charles, D., Charlwood, A., Chatzifotiou, S., Chell, K., Chen, L., Chen, Q., Chen, W.-J., Ching, L., Christensen, J., Ciasullo, M.V., Cimermanová, I., Činčera, J., Cipollina, M., Clutterbuck, R., Cochrane, B., Collin, K., Conley, R., Connell, H., Connelly, J., Connelly, L., Connelly, R., Conti, D., Conversi, D., Conway, G., Cooper, S., Cope, M., Corsini, F., Cristian, P., Crohn, H.M., Croog, R.C., Salazar, T., Csiszár, C., D’auria, I., D’souza, A., D’souza, N., Dabija, D.-C., Dagg, J., Dalby, S., DaleDalsgård, B., Dʹamato, A.L., Daniel, D., Dant, L., Dantas, C., Darwin, H., Dashper, K., David, M.E., De Flippo, D., De, A., Edi, M., Velázquez, E.D.C., Velázquez, F., Del Vecchio, P., Delatolla, A., Delgado, P., Delgado‐romero, E., Delrosso, J., Desimone, J., Detlefsen, L., Devaney, C., Díaz, L.M., Didham, R., Diogo, E., Dirakis, A., Doberneck, D., Doidge, M.D., Molero, G., Dombrowski, P.J., Doñate, C., Đorđević, Martín, Reis, P.G.R., Doucek, P., Dundes, L., Dvouletý, O., Dybo, T., Eastman, J., Eckhardt, J., Economou, A., Edler, D., Edu, U., Ekblom, P.E., Khaled, D., Ellis, C., Elsabry, E., Erceg, A., Erokhin, V., Ertz, M., Everitt, J., Evers, A., Falcone, P.M.F., Cabana, P., Fawcett, B., Fearnley, B., Featherstone, M., Ferreira, M., Ferreira, P., Fetner, T., Fisher, J., Fisher, R., Fitzpatrick, T., Flanagan, C., Fogarty, E.A., Fonchingong, C.C., Fontana, M., Fook, J., Foreman, A.M., Foster‐mcgregor, N., Fox, S., Franco, J.A., Franklin, A.L., Friedrich, T., Fromm, I., Fu, N., Fucà, R., Fukuda, Y., Fusco, G., Gabriela, D., Galan, D., Gamo, A., Galiano, J., Garcia, A., García, M.E.A., García‐germán, S., García‐machado, J.J., García‐ruiz, C.R., Gavini, M., Gazzano, A., Gebhardt, M., Gerson, S., Gherghina, Ş.C., Gibbs, P., Gilhooly, D., Gill, F., Gill, N., Gil‐lopez, A.J., Ginès Fabrellas, A., Giuffrida, N., Giuliani, G., Goddard, J., Godderis, R., Goh, C.S., Gomes, O., Goncharuk, A.G., Canche, M.G., Pérez, I.G., Valero, G., González, R.C.L., Gonzalez‐benson, O., Gonzalez‐feliu, J., González‐lópez, M., Gozdziak, E., Granx, B., Gran, R., Gray, S.L., Grbes, A., Grondys, K., Grugan, S., Guenther, J., Guijarro, F., Gurko, T., Haas, L.L., Hagellx, A., Hagell, H., Hallgrímsdóttir, H., Hamada, T., Hanf, J., Hannouf, M., Hao, F., Harman, G., Harris, K.L., Harris, R., Harrison, N.H., Healy, G., Healy, K., Heikkilä, E., Hellmich, C., Henig, J., Henninger, C.E., Heo, W., Herman, C., Herrero‐diz, P., Heyman, J., Hibbert, N., Hillman, A.L., Hillman, B., Hine, B., Hino, K., Hinten, M., Hipp, L., Hoang, D., Holleran, D., Hollin, I., Holm, M., Holmes, C., Hook, G., Hoornweg, D., Hopper, L., Hossain, M., Hoxhaj, R., Hu, B., Huang, Y., Huarita, E., Hudec, O., Humbert, A.L., Hung, M.-C., Hunt, A., Husu, L., IanoleIbáñez‐gonzález, R., Ibáñez‐gonzález, M.J., Ide, T., Ijaz, Muhammad Fazal, Impicciatore, R., Ingwersen, M., Ioannides, D., Iseppi, L., Islam, M.M., Jaakkola, M., Jagger, S., Jagosh, J., Jenkin, G., Joelsson, T., Johansen, R.E.B., Johnsen, H.C., Garmann Jona, G., Jones, T., Judit, O., Kalalahti, M., Kang, M., Kantamaneni, K., Kaplan, L., Kapsalis, V., Karbowski, A., Katsoni, V., Kavish, D.R., Kawamura, H., Keilman, N.W., Kelly, J., Kenneth, H., Kepaptsoglou, K., Kevin, D., Kewley, S., Kim, J.-C., Kim, K.-Y., Kim, S., Kimengsi, J.N., Klein, J., Kleine, M., Klemes, J.I.R.I., Klepp, S., Klinkenberg, L.E.F., Knight, L., Knowles, J., Koerner, S., Konsolakis, K., Konstantinov, V., Kopkin, N.K., Kordova, S., Kosinski, E., Kostelka, F., Kot, S., Kotter, R., Kramers, A., Krienert, J.L., Kubon, M., Kuffer, M., Kungolos, A., Kuttner, P., Kużelewska, E., Ladd, A.E., Lammi, M., Landrum, J., Lange, B., Languilaire, T.D., Lantz, J.-C., Laudal, B., Laurentsyeva, T., Lavizzari, N., Lavoie, A., Feuvre, J.L., Leakey, N., Lee, R., Lee, A., Lee, E., Lee, J., Lentner, J.-H., Lenz‐taguchi, C., Leong, H., Levac, W.S., Lewin, L., Lewinson, E., Li, T., Li, F., Li, G., Li, M., Liczmańska‐kopcewicz, Y., Lillard, K., Linková, C., Links, M., Lipinski, P., Storto, J.L., Lochtman, C., Lockwood, K., Loh, A., Lomonaco‐benzing, V., Łopaciuk‐gonczaryk, R., López, B., lópez, D., Lorenzini, J., Löther, A., Loughnan, C., Love, T., Lucas, M.L., Ubago, J., Lukić, J., Lumley‐sapanski, A., Macedo, I., Macfarlane, S., Machimbarrena, J.M., Magda, R., Magrane, D., Maier, D., Majić, S., Majumdar, S., Makarovič, M., Malekigorji, M., Mallick, B., Malone, D., Mandić, D., Maniou, T., Mannell, J.M., Barbutiu, S., Marczak, M., Markvica, K.M., Aragón, M.D.M., Martín, J.S.M., Pereira, A., Marzal‐felici, J., Mason, F., Mather, J., Matijosaitiene, I., MatthewsMattisson, R., Mattisson, C., Matuszak, Ł., Matuzeviciute, K., Mauerer, G., Mayer, A., McCaig, C., McClearn, D., McKee, S.C., McKendry, S., McMahon, M., McReynolds, P., Medina‐vicent, M., Medyna, G., Mees, H., Meil, G., Meringolo, P., Miciuła, I., Milczarek‐andrzejewska, D., Miles, P., Milivojević, S., Miller, G., Minello, A., Miron, D., Mironeasa, S., Misra, J., Mitchell, T., Moldovan, O., Molero, P.P., Møllersen, S., Momsen, J.H., Moniz, A.B., Morea, D., Moreau, M.-P., Morgan, D.L., Morgan, H., Moscatelli, S., Mostowska, M., Mousavi, A., Mousavi, S., Mrugalska, B., Muinos, G., Mukungu, K., Mukuni, J., Murakami, D., Muresan, I.C., Murib, Z., Muro, A., Mustafa, G., Nackerud, L., Nalmpantis, D., Napal, M., Närvi, J., Naser, M., Nash, V., Navarre‐jackson, L., Navarro, R., Nazarczuk, D., Neale, J., Necula, J., Němec, S., Neven, D., Nevgi, A., Newbold, A., Newton, G., New, A., Niakšu, O., Niiniluoto, I., Nkogo, J.C., Nobre, S., Nunn, P., Oakes, R., Obrad, C., Oke, A., Okorie, O., Oncioiu, I., Ormsbee, F., Ortega‐sánchez, D., Osgood, J., Osorio, C., Oswald, J., Otis, M.D., Ouassini, A., Oxford, S., Page, T., Paixão, M.J., De Pajares, E.M., Palmesr, E., Palos‐sánchez, P., Pamučar, Dragan, Pan, H., Panek, J., Pankowska, M., Papadakis, S., Papafilippou, V.P., Medina, R., Park, C.S., Partalidou, M., Passantino, A., Passini, S., Paul, S., Pavliuk, R., Pearce, P., Pease, K., Pentaris, P., Perez, V.W., Pérez‐armendáriz, C., Perez‐vaisvidovsky, N., Perez‐y‐perez, M., Perry, N., Prtchu, D., Peterson, D.A.M., Alexandru‐ionut, Petrykowski, Petrykowski, P., Phillips, L., Pickard, S., Pickel, A., Pieke, F., Piekut, A., Pierce, S., Pierrakis, Y., Piguet, E., Pleace, N., Połom, M., Polsa, P., Ponticorvo, M., Pookulangara, S., Pope, J., Popoli, P., Postigo, J.C., Price‐Wolf, J., Prior, S., Privitera, D., Prud’homme, C., Prosser, J., Prus, P., Puiu, S., Purcell, R., Pyrialakou, D., Quam‐wickham, N., Quarmby, T., Quinlan, K.M., Quinn, A., Quinn, R., Raciti, M., Radicić, D., Rahimi, B., Ramlo, S., Randle, H., Ratajczak, M., Raymond, T., Recio‐menéndez, M., Reese, L.A., Regner, T., Reichman, J., WReim, iebke, R., Pastor, A.M., Rexhepi, G., Reyes‐menendez, A., Reynaud, C., Ribeiro‐soriano, D., Ricci, S., Ridaura, G., Rita, C., Roberts, M., Roberts, G., Roberts, K., Rockerbie, D., Rodger, J.A., Rodin, G., Rodrigues, D.R., Martín, J.A., Rodríguez, C.F., Rodriguez‐modroño, P., Romero‐rodríguez, L.M., Rončáková, T., Roper, I., Rorie, M.R., Marzán, C.F., Rose, G., Rose, M., Rosen, R., Roth, R., Roubík, H., Roumpos, C., Rowbottom, D., Roy, J., Ruban, D., Rubira‐garcía, R., Ruiperez‐valiente, J.A., Ruiz, R., Ruiz‐real, J.L., Russell, B., Russo, K., Sabol, W., Safonte, F., Salin, M., Salom‐carrasco, J.S., Sánchez, L.D., Sanghera, Santos, B.S., Silva, D., Sanz, F., Sanz‐altamira, B., Sarapura, S., Sari, D., Satybaldieva, E., Saura, J.R., Sayed, N., Scandurra, C., Schartner, A., Schellekens, J., Schenk‐hoppé, K.R., Scherer, L., Schewe, J.A., Schewe, R., Schiller, N.G., Schmidt, E.-M., Schneickert, C., Schneider, J., Scott, H., Scott, P., Seibel, K., Seidler, R., Seifert, S.S., Puyuelo, M.S., Azevedo, P.S., Lopez, A.E.S., Raamkumar, A.S., Blundo, D., Severo, M., Shakya, K.M., Shapiro, A., Shaw, I.F., Shaw, T.V., Shea, B., Shearer, H., Sheldon, S., Shell‐duncan, B., Shepherd, S., Sheridan, L., Siemienska, R., Sillup, G.P., Simeon, J.C., Simonelli, A., Skilodimou, H.D., Škrinjarić, T., Slater, G., Smardon, R., Smith, J., Smoląg, K., Snauwaert, D.T., Soanes‐white, T., Sobocińska, M., Sohaib, O., Soldatić, K., Sorainen, G.T., Soldatos, A., Sørensen, N.N., Spanu, S., Stadlober, E., Stafford, F., Ștefănescu‐mihăilă, R.O., Stefanini, A., Štefko, R., Steglich, E., Steirer, G., Stephenson, M.O., Stoecker, R., Stoffelen, A., Strang, A., Suppa, D., Sutton, J., Svobodová, L., Swigon, M., Synnott, J., Sytsma, V., Tabe, T., Tajeddini, K., Tang, S., Taylor, B., Taylor, C., Teignier, M., Teixeira, C., Tempelaar, D., Ter Avest, K.H., Ter Horst, E., Testa, M.R., Thakur, N., Thiamwong, L., Thijsen, A., Thomas, B.A., Thompson, C., Thompson, D., Tisdall, K., Toft, Mancini, Torell, A., Toscano‐hernández, G., Tregua, A.E., Triandafyllidou, M., Tseloni, A., Seloni, A., Tsikouras, P., Tsogas, G., Twamley, K., Tyler, D.U., Haque, A., Underwood, M., Urbański, M., Uribe‐toril, J., Vaezipour, A., Van Hove, L.V., Huylenbroeck, G., Van Nuland, S., Vanner, C., Vázquez‐cano, E., Veen, E., Veintimilla, S.G.-A., Veković, M., Velija, P., Venco, E.M., Verticelli, A., Vicente, P.V., Estiarte, C., Višnjić, A., Visvizi, A., Vlasblom, J.D., Volsche, S.V., Fintel, D., Von Keyserlingk, L., Vranješević, J., Walter, K.V., Wandosell, G., Wang, Y., Wasileski, G., Wastl‐walter, D., Weaving, C., Weenik, D., Wehr, K., Wei, X., Wharton, A., White, G., Whitehouse, H., Whitley, C.T., Whitman, L., Wiersma‐mosley, J.D., Wilcke, H., Wilkes, R., Williams, L., Williamson, R.D., Wimalasena, L., Wiseman, A., Wołek, M., Wright, E.Q., Wroblewski, A., Wyile, A.S., Wynn, C., Xu, X., Xue, B., Yang, J., Yoe, T.M., Young, M., Younus, M., Yu, T.-F., Yuan, Q., Zadra, C., Zaharijević, A., Zajda, J., Zander, K., Zbuchea, A., Zelin, A., Zhang, C., Zippel, K., Zitricky, V., Živanović, P., Zou, L., Zufferey, C., Zuhdi, M., Zumeta, W.M., Abbas, A., Abel, G., Abreu, A., Adam, A., Adamek, M., Adiletta, G., Adusei-asante, K.A., Romeo, M.D.M., Alderson, A., Alfaro, E., Aliverti, A., Almeida, Fernando, Álvarez-gonzález, L.I., Amelina, A., Anand, C., Anderson, G., Andreasson, J., Ang, I., Aragon, J., Arcidiacono, C., Arcuri, S., Assante, D., Atukeren, E., Avery, H., Ayeb-karlsson, S., Azadi, H., Bachman, R., Bader, M., Badulescu, A., Bahmanteymouri, E., Baines, S., Baker, T., Baker‐beall, C., Bañón, L., Bar‐am, N., Barbier‐greenland, K., Barnett, R., Barragán‐escandón, A., Barreto, A.M., Barrett, E., Bartkowski, J., Bartram, R., Bartzas, G., Bates, D., Baviera‐puig, A., Bayley, A., Beazley, H., Beer, C., Behr, H., Beier, G., Belford, N., Bencivenga, R., Benli, A.E., Benton‐short, L., Berei, J.M., Berbel‐pineda, E., Bernstein, Berntzen, E.R., Bertella, L., Birney, G., Bittle, M., Black, S., Rivero, L.B., Blattner, J.J., Blok, C., Blount, A., Boas, Y., Bockarie, I., Bockerman, A., Bodén, P., Bönisch‐brednich, L., Bontje, B., Bontje, M., Borsellino, V., Bostan, I., Bowl, M., Bowman, B., Bracci, E., Bracken, C.M., Bradley, H., Brereton, P., Brewer, J., Bridge, D., Brooks, S., Brown, Andrijana, Brzoska, M., Brzozowski, W., Buckley, G., Buente, W., Bullaro, G.R., Burke, M.D., Burlacu, S., Busu, M., Butler, S., Byrne, J., Cabral, L., Cai, Y., Cajias, M., Calin, A.C., Callegari, C., Camarero, M., Campbell-figuerola, H., Campbell, J.R., Cannito, M., Canonico, E., Canosa, A., Carabelli, G., Carlbom, A., Carlone, T., Caron, R., Carpenter, A., Caruso, G., Casais, B., Castro, M.P., Cava, M.-J., Čeněk, J., Cerchione, R., Certomà, C., Chan, E., Charles, D., Charlwood, A., Chatzifotiou, S., Chell, K., Chen, L., Chen, Q., Chen, W.-J., Ching, L., Christensen, J., Ciasullo, M.V., Cimermanová, I., Činčera, J., Cipollina, M., Clutterbuck, R., Cochrane, B., Collin, K., Conley, R., Connell, H., Connelly, J., Connelly, L., Connelly, R., Conti, D., Conversi, D., Conway, G., Cooper, S., Cope, M., Corsini, F., Cristian, P., Crohn, H.M., Croog, R.C., Salazar, T., Csiszár, C., D’auria, I., D’souza, A., D’souza, N., Dabija, D.-C., Dagg, J., Dalby, S., DaleDalsgård, B., Dʹamato, A.L., Daniel, D., Dant, L., Dantas, C., Darwin, H., Dashper, K., David, M.E., De Flippo, D., De, A., Edi, M., Velázquez, E.D.C., Velázquez, F., Del Vecchio, P., Delatolla, A., Delgado, P., Delgado‐romero, E., Delrosso, J., Desimone, J., Detlefsen, L., Devaney, C., Díaz, L.M., Didham, R., Diogo, E., Dirakis, A., Doberneck, D., Doidge, M.D., Molero, G., Dombrowski, P.J., Doñate, C., Đorđević, Martín, Reis, P.G.R., Doucek, P., Dundes, L., Dvouletý, O., Dybo, T., Eastman, J., Eckhardt, J., Economou, A., Edler, D., Edu, U., Ekblom, P.E., Khaled, D., Ellis, C., Elsabry, E., Erceg, A., Erokhin, V., Ertz, M., Everitt, J., Evers, A., Falcone, P.M.F., Cabana, P., Fawcett, B., Fearnley, B., Featherstone, M., Ferreira, M., Ferreira, P., Fetner, T., Fisher, J., Fisher, R., Fitzpatrick, T., Flanagan, C., Fogarty, E.A., Fonchingong, C.C., Fontana, M., Fook, J., Foreman, A.M., Foster‐mcgregor, N., Fox, S., Franco, J.A., Franklin, A.L., Friedrich, T., Fromm, I., Fu, N., Fucà, R., Fukuda, Y., Fusco, G., Gabriela, D., Galan, D., Gamo, A., Galiano, J., Garcia, A., García, M.E.A., García‐germán, S., García‐machado, J.J., García‐ruiz, C.R., Gavini, M., Gazzano, A., Gebhardt, M., Gerson, S., Gherghina, Ş.C., Gibbs, P., Gilhooly, D., Gill, F., Gill, N., Gil‐lopez, A.J., Ginès Fabrellas, A., Giuffrida, N., Giuliani, G., Goddard, J., Godderis, R., Goh, C.S., Gomes, O., Goncharuk, A.G., Canche, M.G., Pérez, I.G., Valero, G., González, R.C.L., Gonzalez‐benson, O., Gonzalez‐feliu, J., González‐lópez, M., Gozdziak, E., Granx, B., Gran, R., Gray, S.L., Grbes, A., Grondys, K., Grugan, S., Guenther, J., Guijarro, F., Gurko, T., Haas, L.L., Hagellx, A., Hagell, H., Hallgrímsdóttir, H., Hamada, T., Hanf, J., Hannouf, M., Hao, F., Harman, G., Harris, K.L., Harris, R., Harrison, N.H., Healy, G., Healy, K., Heikkilä, E., Hellmich, C., Henig, J., Henninger, C.E., Heo, W., Herman, C., Herrero‐diz, P., Heyman, J., Hibbert, N., Hillman, A.L., Hillman, B., Hine, B., Hino, K., Hinten, M., Hipp, L., Hoang, D., Holleran, D., Hollin, I., Holm, M., Holmes, C., Hook, G., Hoornweg, D., Hopper, L., Hossain, M., Hoxhaj, R., Hu, B., Huang, Y., Huarita, E., Hudec, O., Humbert, A.L., Hung, M.-C., Hunt, A., Husu, L., IanoleIbáñez‐gonzález, R., Ibáñez‐gonzález, M.J., Ide, T., Ijaz, Muhammad Fazal, Impicciatore, R., Ingwersen, M., Ioannides, D., Iseppi, L., Islam, M.M., Jaakkola, M., Jagger, S., Jagosh, J., Jenkin, G., Joelsson, T., Johansen, R.E.B., Johnsen, H.C., Garmann Jona, G., Jones, T., Judit, O., Kalalahti, M., Kang, M., Kantamaneni, K., Kaplan, L., Kapsalis, V., Karbowski, A., Katsoni, V., Kavish, D.R., Kawamura, H., Keilman, N.W., Kelly, J., Kenneth, H., Kepaptsoglou, K., Kevin, D., Kewley, S., Kim, J.-C., Kim, K.-Y., Kim, S., Kimengsi, J.N., Klein, J., Kleine, M., Klemes, J.I.R.I., Klepp, S., Klinkenberg, L.E.F., Knight, L., Knowles, J., Koerner, S., Konsolakis, K., Konstantinov, V., Kopkin, N.K., Kordova, S., Kosinski, E., Kostelka, F., Kot, S., Kotter, R., Kramers, A., Krienert, J.L., Kubon, M., Kuffer, M., Kungolos, A., Kuttner, P., Kużelewska, E., Ladd, A.E., Lammi, M., Landrum, J., Lange, B., Languilaire, T.D., Lantz, J.-C., Laudal, B., Laurentsyeva, T., Lavizzari, N., Lavoie, A., Feuvre, J.L., Leakey, N., Lee, R., Lee, A., Lee, E., Lee, J., Lentner, J.-H., Lenz‐taguchi, C., Leong, H., Levac, W.S., Lewin, L., Lewinson, E., Li, T., Li, F., Li, G., Li, M., Liczmańska‐kopcewicz, Y., Lillard, K., Linková, C., Links, M., Lipinski, P., Storto, J.L., Lochtman, C., Lockwood, K., Loh, A., Lomonaco‐benzing, V., Łopaciuk‐gonczaryk, R., López, B., lópez, D., Lorenzini, J., Löther, A., Loughnan, C., Love, T., Lucas, M.L., Ubago, J., Lukić, J., Lumley‐sapanski, A., Macedo, I., Macfarlane, S., Machimbarrena, J.M., Magda, R., Magrane, D., Maier, D., Majić, S., Majumdar, S., Makarovič, M., Malekigorji, M., Mallick, B., Malone, D., Mandić, D., Maniou, T., Mannell, J.M., Barbutiu, S., Marczak, M., Markvica, K.M., Aragón, M.D.M., Martín, J.S.M., Pereira, A., Marzal‐felici, J., Mason, F., Mather, J., Matijosaitiene, I., MatthewsMattisson, R., Mattisson, C., Matuszak, Ł., Matuzeviciute, K., Mauerer, G., Mayer, A., McCaig, C., McClearn, D., McKee, S.C., McKendry, S., McMahon, M., McReynolds, P., Medina‐vicent, M., Medyna, G., Mees, H., Meil, G., Meringolo, P., Miciuła, I., Milczarek‐andrzejewska, D., Miles, P., Milivojević, S., Miller, G., Minello, A., Miron, D., Mironeasa, S., Misra, J., Mitchell, T., Moldovan, O., Molero, P.P., Møllersen, S., Momsen, J.H., Moniz, A.B., Morea, D., Moreau, M.-P., Morgan, D.L., Morgan, H., Moscatelli, S., Mostowska, M., Mousavi, A., Mousavi, S., Mrugalska, B., Muinos, G., Mukungu, K., Mukuni, J., Murakami, D., Muresan, I.C., Murib, Z., Muro, A., Mustafa, G., Nackerud, L., Nalmpantis, D., Napal, M., Närvi, J., Naser, M., Nash, V., Navarre‐jackson, L., Navarro, R., Nazarczuk, D., Neale, J., Necula, J., Němec, S., Neven, D., Nevgi, A., Newbold, A., Newton, G., New, A., Niakšu, O., Niiniluoto, I., Nkogo, J.C., Nobre, S., Nunn, P., Oakes, R., Obrad, C., Oke, A., Okorie, O., Oncioiu, I., Ormsbee, F., Ortega‐sánchez, D., Osgood, J., Osorio, C., Oswald, J., Otis, M.D., Ouassini, A., Oxford, S., Page, T., Paixão, M.J., De Pajares, E.M., Palmesr, E., Palos‐sánchez, P., Pamučar, Dragan, Pan, H., Panek, J., Pankowska, M., Papadakis, S., Papafilippou, V.P., Medina, R., Park, C.S., Partalidou, M., Passantino, A., Passini, S., Paul, S., Pavliuk, R., Pearce, P., Pease, K., Pentaris, P., Perez, V.W., Pérez‐armendáriz, C., Perez‐vaisvidovsky, N., Perez‐y‐perez, M., Perry, N., Prtchu, D., Peterson, D.A.M., Alexandru‐ionut, Petrykowski, Petrykowski, P., Phillips, L., Pickard, S., Pickel, A., Pieke, F., Piekut, A., Pierce, S., Pierrakis, Y., Piguet, E., Pleace, N., Połom, M., Polsa, P., Ponticorvo, M., Pookulangara, S., Pope, J., Popoli, P., Postigo, J.C., Price‐Wolf, J., Prior, S., Privitera, D., Prud’homme, C., Prosser, J., Prus, P., Puiu, S., Purcell, R., Pyrialakou, D., Quam‐wickham, N., Quarmby, T., Quinlan, K.M., Quinn, A., Quinn, R., Raciti, M., Radicić, D., Rahimi, B., Ramlo, S., Randle, H., Ratajczak, M., Raymond, T., Recio‐menéndez, M., Reese, L.A., Regner, T., Reichman, J., WReim, iebke, R., Pastor, A.M., Rexhepi, G., Reyes‐menendez, A., Reynaud, C., Ribeiro‐soriano, D., Ricci, S., Ridaura, G., Rita, C., Roberts, M., Roberts, G., Roberts, K., Rockerbie, D., Rodger, J.A., Rodin, G., Rodrigues, D.R., Martín, J.A., Rodríguez, C.F., Rodriguez‐modroño, P., Romero‐rodríguez, L.M., Rončáková, T., Roper, I., Rorie, M.R., Marzán, C.F., Rose, G., Rose, M., Rosen, R., Roth, R., Roubík, H., Roumpos, C., Rowbottom, D., Roy, J., Ruban, D., Rubira‐garcía, R., Ruiperez‐valiente, J.A., Ruiz, R., Ruiz‐real, J.L., Russell, B., Russo, K., Sabol, W., Safonte, F., Salin, M., Salom‐carrasco, J.S., Sánchez, L.D., Sanghera, Santos, B.S., Silva, D., Sanz, F., Sanz‐altamira, B., Sarapura, S., Sari, D., Satybaldieva, E., Saura, J.R., Sayed, N., Scandurra, C., Schartner, A., Schellekens, J., Schenk‐hoppé, K.R., Scherer, L., Schewe, J.A., Schewe, R., Schiller, N.G., Schmidt, E.-M., Schneickert, C., Schneider, J., Scott, H., Scott, P., Seibel, K., Seidler, R., Seifert, S.S., Puyuelo, M.S., Azevedo, P.S., Lopez, A.E.S., Raamkumar, A.S., Blundo, D., Severo, M., Shakya, K.M., Shapiro, A., Shaw, I.F., Shaw, T.V., Shea, B., Shearer, H., Sheldon, S., Shell‐duncan, B., Shepherd, S., Sheridan, L., Siemienska, R., Sillup, G.P., Simeon, J.C., Simonelli, A., Skilodimou, H.D., Škrinjarić, T., Slater, G., Smardon, R., Smith, J., Smoląg, K., Snauwaert, D.T., Soanes‐white, T., Sobocińska, M., Sohaib, O., Soldatić, K., Sorainen, G.T., Soldatos, A., Sørensen, N.N., Spanu, S., Stadlober, E., Stafford, F., Ștefănescu‐mihăilă, R.O., Stefanini, A., Štefko, R., Steglich, E., Steirer, G., Stephenson, M.O., Stoecker, R., Stoffelen, A., Strang, A., Suppa, D., Sutton, J., Svobodová, L., Swigon, M., Synnott, J., Sytsma, V., Tabe, T., Tajeddini, K., Tang, S., Taylor, B., Taylor, C., Teignier, M., Teixeira, C., Tempelaar, D., Ter Avest, K.H., Ter Horst, E., Testa, M.R., Thakur, N., Thiamwong, L., Thijsen, A., Thomas, B.A., Thompson, C., Thompson, D., Tisdall, K., Toft, Mancini, Torell, A., Toscano‐hernández, G., Tregua, A.E., Triandafyllidou, M., Tseloni, A., Seloni, A., Tsikouras, P., Tsogas, G., Twamley, K., Tyler, D.U., Haque, A., Underwood, M., Urbański, M., Uribe‐toril, J., Vaezipour, A., Van Hove, L.V., Huylenbroeck, G., Van Nuland, S., Vanner, C., Vázquez‐cano, E., Veen, E., Veintimilla, S.G.-A., Veković, M., Velija, P., Venco, E.M., Verticelli, A., Vicente, P.V., Estiarte, C., Višnjić, A., Visvizi, A., Vlasblom, J.D., Volsche, S.V., Fintel, D., Von Keyserlingk, L., Vranješević, J., Walter, K.V., Wandosell, G., Wang, Y., Wasileski, G., Wastl‐walter, D., Weaving, C., Weenik, D., Wehr, K., Wei, X., Wharton, A., White, G., Whitehouse, H., Whitley, C.T., Whitman, L., Wiersma‐mosley, J.D., Wilcke, H., Wilkes, R., Williams, L., Williamson, R.D., Wimalasena, L., Wiseman, A., Wołek, M., Wright, E.Q., Wroblewski, A., Wyile, A.S., Wynn, C., Xu, X., Xue, B., Yang, J., Yoe, T.M., Young, M., Younus, M., Yu, T.-F., Yuan, Q., Zadra, C., Zaharijević, A., Zajda, J., Zander, K., Zbuchea, A., Zelin, A., Zhang, C., Zippel, K., Zitricky, V., Živanović, P., Zou, L., Zufferey, C., Zuhdi, M., and Zumeta, W.M.

Published
2020

40. Exploring the boundaries of the passive greenhouse in Jordan: A modelling approach

Author

Baeza Romero, E.J., van Os, E.A., van der Salm, C., Tsafaras, I., Blok, C., Baeza Romero, E.J., van Os, E.A., van der Salm, C., Tsafaras, I., and Blok, C.

Abstract

Greenhouses are expanding fast in arid and semi-arid regions, among other reasons, because of the water savings that can be realized compared to open field cultivation. However, it is difficult for growers to recognize the optimum greenhouse design. Many competing aspects must be weighed against each other such as the structure, the cover and the climate control equipment. Obviously, the optimum design must be tailored for each specific crop and growing cycle and availability of resources (land, water, energy, labor, etc.). Simulation models can assist in this process, saving time and money. Wageningen University & Research, BU Greenhouse Horticulture has developed the Adaptive Greenhouse Methodology. It combines the use of greenhouse climate and resources simulation models, with crop growth and economic models, to solve the problem of designing the optimum greenhouse for each specific scenario in the world. In the present work we present the results of the application of this methodology to the specific case of the production of greenhouse soilless tomato in two regions in Jordan in the mid tech range: the highlands and the Jordan Valley. Results show that different mid tech designs could potentially provide yield levels of up to 35 and 27 kg m-2 in the Highlands and the Jordan Valley, respectively. The final design is similar in the two locations.

Published
2020

41. An investment order tool to guide development of greenhouse horticulture for two specific regions

Author

Blok, C., Leyh, R., Baeza Romero, E.J., van Os, E.A., van der Salm, C., Blok, C., Leyh, R., Baeza Romero, E.J., van Os, E.A., and van der Salm, C.

Abstract

Growers worldwide often lack means to find the economically soundest order of investing. Authorities face similar problems when deciding which developments to stimulate. For Dutch greenhouse horticulture, models for production, climate, revenue and costs, allow selection of an optimal investment order. This approach was widened into “Adaptive Greenhouse Methodology” which allows evaluation of worldwide climate and greenhouse technology combinations. However, running the models requires expert skills. Our goal was to deliver a simplified software tool, which would allow horticultural suppliers, researchers and growers to autonomously rank alternative investments, for a specific combination of region, greenhouse design and crop. The Investment Order Tool was developed in cooperation with selected horticultural supply companies for the regions Almeria in Spain and the Jordan Valley. In Spain, a flat roofed Parral type greenhouse was compared to an industrial multi-span greenhouse. In Jordan a single tunnel greenhouse was compared to an industrial multi-span greenhouse with passive crop based cooling. The Investment Order Tool uses a one-time run of the Adaptive Greenhouse Methodology based on local information. This data set allows further off-line calculations. All adaptions in greenhouse construction and cultivation system are defined as relative production changes from the local standard. The adaptations are provided with their specific costs and benefits. The investments compared include: reverse osmosis; substrates; nutrient dosing; climate-adapted cultivars; recirculation of drainage water; ventilation capacity; shading screens and thermal screens. The Investment Order Tool informed growers on the investment order with the highest return on investment and the investment order with the lowest demand for capital. Nursery specificity was realized by permitting user defined yield and market price level per month and by defining a first and second class for product qu

Published
2020

42. Strategy to minimise nitrogen load to finish a zero discharge cultivation

Author

Leyh, R., Van Os, E.A., Blok, C., Van Ruijven, J.P.M., Kaarsemaker, R., Leyh, R., Van Os, E.A., Blok, C., Van Ruijven, J.P.M., and Kaarsemaker, R.

Abstract

The Dutch authorities established a plan for the reduction of water emissions from the greenhouse sector to become zero by 2027, to enforce the European Union Water Framework Directive. At the end of the cultivation period, a considerable amount of nitrate and phosphate is still present in solution in substrate slabs and in the irrigation system. The left over nutrient solution is generally discharged into the sewage system or surface water. The end of cultivation strategy was developed to use the plant uptake to reduce this nitrate and phosphate in the last 5 weeks of the cultivation period. This reduction should be realised without affecting the production or quality of the last fruits to be harvested. The strategy consisted of a gradual decrease over the last five weeks of the cultivation of nitrate, phosphate and water quantity supplied to the plant. Chloride was used to replace nitrate in the supply water. The anion-shift allowed maintaining a sufficient quantity of cations in the root environment to meet the plant's needs and to avoid production loss. A progressive shift from nitrate-nitrogen to ammonium-nitrogen was realised. The nitrogen-shift acidified the substrate slabs to release precipitated phosphate. A double irrigation cycle at the start of the day was implemented during the strategy to anticipate nutrient accumulation in the root environment. In 2016, the strategy was applied to a sweet-pepper cultivation. The water volume in the substrate slabs was reduced from 6 to 3.5 L m-2. Nitrate quantity was reduced from 109 to 55 mmol m-2. Phosphate quantity was reduced from 0.5 to 0.2 mmol m-2. In 2017, the strategy was applied to a cucumber cultivation. The average water volume was reduced from 8 to 5.3 L m-2. Average nitrate quantity was reduced from 113 to 45 mmol m-2 and average phosphate quantity from 4.5 to 1.65 mmol m-2,.

Published
2020

43. Ebb and flood nutrient delivery system for sustainable automated crop production

Author

Giacomelli, G.A., van Weel, P.A., Blok, C., Giacomelli, G.A., van Weel, P.A., and Blok, C.

Abstract

For more than 40 years ebb and flood irrigation and nutrient delivery systems have been nurturing crops within greenhouse controlled environments. Bedding plants, potted plants, cut flowers and even tomatoes have been produced. An overview and critical discussion of the delivery of water, dissolved oxygen and plant nutrients to the root zone of the crop using the ebb and flood principles is discussed in this article. Ebb and flood systems have functioned within automated crop production systems from table transport devices to concrete floor heating systems. The benefits were the easily manageable means to uniformly provide water, dissolved oxygen and plant nutrients to the root zone of the crop, without requiring a fixed plumbing connection, either for inflow during flood or for drainage at ebb. The results were effective transport of water, nutrients and oxygen from the bottom of the root zone upwards, and with saturation of the bottom of the root zone, allowing minimal flushing of nutrients and other dissolved substances from the root zone. All unused irrigation water was collected and returned to storage for future use, creating a recirculating hydroponic system which conserved water and nutrients and directly benefited the environment by eliminating discharge. Fundamental design criteria and operation management practices; integration with concrete floor heating system; and, examples of successful applications are discussed, as are limitations and future applications.

Published
2020

44. Zero liquid discharge in soilless greenhouse horticulture : Solutions to save water and the environment while ensuring an optimal production

Author

Van Os, E.A., Beerling, E.A.M., Blok, C., Leyh, R., Van Ruijven, J.P.M., Van Der Staaij, M., Janse, J., Kaarsemaker, R., Roosen, W., Van Os, E.A., Beerling, E.A.M., Blok, C., Leyh, R., Van Ruijven, J.P.M., Van Der Staaij, M., Janse, J., Kaarsemaker, R., and Roosen, W.

Abstract

Zero liquid discharge (ZLD) should be the future for soilless production. In The Netherlands emission of nutrients and plant protection products to surface water is the main reason to investigate the potentials of cultivation methods without any discharge. In a few other countries water pollution issues is the main motive, but for a majority water shortage and the increasing competition for water of an acceptable quality is reason for the growing need for water efficient cultivation methods. During four years ZLD was investigated for cucumber (2014, 2017) and sweet pepper (2015, 2016). The primary goal was to reuse all drain water, while maintaining a similar yield and quality as in the traditional growing method with regular discharges. To achieve ZLD all practical reasons for growers to discharge the nutrient solution had to be anticipated before. In the ZLD trials technical and strategic solutions were jointly tested and further developed into an adapted growing strategy without any discharge. A number of factors could be mentioned as main reasons for discharge: sodium in the supply water, discharge of filter rinsing water, unbalances in the nutrient solution, no recirculation of the drainwater in the beginning of the cultivation, no disinfection equipment, too low drain storage capacity, appearance of calamities (technical failures) and the amount of remnant nutrient solution left in slabs and tanks at the end of the cultivation. The next step was demonstrating the technical and strategic solutions in a cultivation. In 2014 and 2015 we showed that ZLD-cultivation in stone wool substrate was possible without loss of yield and quality. In 2016 and 2017 the more challenging coir substrate was used to investigate the influence of buffering and sodium accumulation. It appeared that ZLD was possible without loss of production or quality. Appearing problems were more in the field of management of water flows than lack of technical equipment. Special care should come fo

Published
2020

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