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5. The severity of chronic histiocytic intervillositis is associated with gestational age and fetal weight

Author

Bos, M, Koenders, M J M, Dijkstra, K L, van der Meeren, L E, Nikkels, P G J, Bloemenkamp, K W M, Eikmans, M, Baelde, H J, van der Hoorn, M L P, Bos, M, Koenders, M J M, Dijkstra, K L, van der Meeren, L E, Nikkels, P G J, Bloemenkamp, K W M, Eikmans, M, Baelde, H J, and van der Hoorn, M L P

Abstract

INTRODUCTION: Chronic histiocytic intervillositis (CHI) is a rare histopathological lesion in the placenta that is associated with poor reproductive outcomes. The intervillous infiltrate consists mostly of maternal mononuclear cells and fibrin depositions, which are both indicators for the severity of the intervillous infiltrate. The severity of the intervillous infiltrate as well as the clinical outcomes of pregnancy differ between cases. Our objective is to determine the relation between the severity of the intervillous infiltrate and the clinical outcomes of CHI.METHODS: Cases of CHI were semi-quantitatively graded based on histopathological severity scores. Hereto, CD68 positive mononuclear cells were quantified, fibrin depositions visualized by both a PTAH stain and an immuohistochemical staining, and placental dysfunction was assessed via thrombomodulin staining.RESULTS: This study included 36 women with CHI. A higher CD68 score was significantly associated with a lower birthweight. Loss of placental thrombomodulin was associated with lower gestational age, lower birthweight, and a lower placenta weight. The combined severity score based on CD68 and PTAH was significantly associated with fetal growth restriction, and the joint score of CD68 and fibrin was associated with birthweight and placental weight.DISCUSSION: More severe intervillous infiltrates in CHI placentas is associated with a lower birth weight and placental weight. Furthermore, this study proposes thrombomodulin as a possible new severity marker of placental damage. More research is needed to better understand the pathophysiology of CHI.

Published
2023

6. Impact of antenatal care on severe maternal and neonatal outcomes in pregnancies complicated by preeclampsia and eclampsia in Ghana

Author

Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Child Health, MS Verloskunde, Beyuo, Titus K, Lawrence, Emma R, Oppong, Samuel A, Kobernik, Emily K, Amoakoh-Coleman, Mary, Grobbee, Diederick E, Browne, Joyce L, Bloemenkamp, K W M, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Child Health, MS Verloskunde, Beyuo, Titus K, Lawrence, Emma R, Oppong, Samuel A, Kobernik, Emily K, Amoakoh-Coleman, Mary, Grobbee, Diederick E, Browne, Joyce L, and Bloemenkamp, K W M

Published
2023

7. Binational confidential enquiry of maternal deaths due to postpartum hemorrhage in France and the Netherlands: Lessons learned through the perspective of a different context of care

Author

MS Verloskunde, Child Health, de Vries, P L M, van den Akker, T, Bloemenkamp, K W M, Grossetti, E, Rigouzzo, A, Saucedo, M, Verspyck, E, Zwart, J, Deneux-Tharaux, C, MS Verloskunde, Child Health, de Vries, P L M, van den Akker, T, Bloemenkamp, K W M, Grossetti, E, Rigouzzo, A, Saucedo, M, Verspyck, E, Zwart, J, and Deneux-Tharaux, C

Published
2023

8. Cost-effectiveness of Diagnostic Testing Strategies Including Cervical-Length Measurement and Fibronectin Testing in Women With Symptoms of Preterm Labor

Author

van Baaren, G.-J., Vis, J. Y., Wilms, F. F., Oudijk, M. A., Kwee, A., Porath, M. M., Scheepers, H. C. J., Spaanderman, M. E. A., Bloemenkamp, K. W. M., Haak, M. C., Bax, C. J., Cornette, J. M. J., Duvekot, J. J., Nij Bijvanck, B. W. A., van Eyck, J., Franssen, M. T. M., Sollie, K. M., Vandenbussche, F. P. H. A., Woiski, M., Bolte, A. C., van der Post, J. A. M., Bossuyt, P. M. M., Opmeer, B. C., and Mol, B. W. J.

Published
2018
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9. The randomised uterine septum transsection trial (TRUST): design and protocol

Author

Rikken, J. F. W., Kowalik, C. R., Emanuel, M. H., Bongers, M. Y., Spinder, T., de Kruif, J. H., Bloemenkamp, K. W. M., Jansen, F. W., Veersema, S., Mulders, A. G. M. G. J., Thurkow, A. L., Hald, K., Mohazzab, A., Khalaf, Y., Clark, T. J., Farrugia, M., van Vliet, H. A., Stephenson, M. S., van der Veen, F., van Wely, M., Mol, B. W. J., and Goddijn, M.

Published
2018
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10. Confidential enquiry into maternal deaths in the Netherlands, 2006–2018

Author

Kallianidis, A. F., Schutte, J. M., Schuringa, L. E. M., Beenakkers, I. C. M., Bloemenkamp, K. W. M., Braams-Lisman, B. A. M., Cornette, J., Kuppens, S. M., Rietveld, A. L., Schaap, T., Stekelenburg, J., Zwart, J. J., van den Akker, T., Kallianidis, A. F., Schutte, J. M., Schuringa, L. E. M., Beenakkers, I. C. M., Bloemenkamp, K. W. M., Braams-Lisman, B. A. M., Cornette, J., Kuppens, S. M., Rietveld, A. L., Schaap, T., Stekelenburg, J., Zwart, J. J., and van den Akker, T.

Abstract

Introduction: To calculate the maternal mortality ratio (MMR) for 2006–2018 in the Netherlands and compare this with 1993–2005, and to describe women’s characteristics, causes of death and improvable factors. Material and Methods: We performed a nationwide, cohort study of all maternal deaths between January 1, 2006 and December 31, 2018 reported to the Audit Committee Maternal Mortality and Morbidity. Main outcome measures were the national MMR and causes of death. Results: Overall MMR was 6.2 per 100 000 live births, a decrease from 12.1 in 1993–2005 (risk ratio [RR] 0.5). Women with a non-western ethnic background had an increased MMR compared with Dutch women (MMR 6.5 vs. 5.0, RR 1.3). The MMR was increased among women with a background from Surinam/Dutch Antilles (MMR 14.7, RR 2.9). Half of all women had an uncomplicated medical history (79/161, 49.1%). Of 171 pregnancy-related deaths within 1 year postpartum, 102 (60%) had a direct and 69 (40%) an indirect cause of death. Leading causes within 42 days postpartum were cardiac disease (n = 21, 14.9%), hypertensive disorders (n = 20, 14.2%) and thrombosis (n = 19, 13.5%). Up to 1 year postpartum, the most common cause of death was cardiac disease (n = 32, 18.7%). Improvable care factors were identified in 76 (47.5%) of all deaths. Conclusions: Maternal mortality halved in 2006–2018 compared with 1993–2005. Cardiac disease became the main cause. In almost half of all deaths, improvable factors were identified and women with a background from Surinam/Dutch Antilles had a threefold increased risk of death compared with Dutch women without a background of migration.

Published
2022

11. Verloskunde

Author

Bloemenkamp, K. W. M., primary, Page-Christiaens, G. C. M. L., additional, and Devlieger, R., additional

Published
2016
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12. Induction versus expectant monitoring for intrauterine growth restriction at term: randomised equivalence trial (DIGITAT)

Author

Boers, K E, Vijgen, S M C, Bijlenga, D, van der Post, J A M, Bekedam, D J, Kwee, A, van der Salm, P C M, van Pampus, M G, Spaanderman, M E A, de Boer, K, Duvekot, J J, Bremer, H A, Hasaart, T H M, Delemarre, F M C, Bloemenkamp, K W M, van Meir, C A, Willekes, C, Wijnen, E J, Rijken, M, le Cessie, S, Roumen, F J M E, Thornton, J, van Lith, J M M, Mol, B W J, and Scherjon, S A

Published
2011

15. Induction of labor with Foley catheter and risk of subsequent preterm birth: follow‐up study of two randomized controlled trials ( PROBAAT ‐1 and ‐2)

Author

de Vaan, M. D. T., primary, Blel, D., additional, Bloemenkamp, K. W. M., additional, Jozwiak, M., additional, ten Eikelder, M. L. G., additional, de Leeuw, J. W., additional, Oudijk, M. A., additional, Bakker, J. J. H., additional, Rijnders, R. J. P., additional, Papatsonis, D. N., additional, Woiski, M., additional, Mol, B. W., additional, and de Heus, R., additional

Published
2021
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20. Induction versus expectant monitoring for intrauterine growth restriction at term: randomised equivalence trial (DIGITAT)

Author

Boers, K E, Vijgen, S M C, Bijlenga, D, van der Post, J A M, Bekedam, D J, Kwee, A, van der Salm, P C M, van Pampus, M G, Spaanderman, M E A, de Boer, K, Duvekot, J J, Bremer, H A, Hasaart, T H M, Delemarre, F M C, Bloemenkamp, K W M, van Meir, C A, Willekes, C, Wijnen, E J, Rijken, M, le Cessie, S, Roumen, F J M E, Thornton, J G, van Lith, J M M, Mol, B W J, and Scherjon, S A

Published
2010
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24. Induction of labor with Foley catheter and risk of subsequent preterm birth: follow-up study of two randomized controlled trials (PROBAAT-1 and -2).

Author

Vaan, M. D. T., Blel, D., Bloemenkamp, K. W. M., Jozwiak, M., Eikelder, M. L. G., Leeuw, J. W., Oudijk, M. A., Bakker, J. J. H., Rijnders, R. J. P., Papatsonis, D. N., Woiski, M., Mol, B. W., Heus, R., de Vaan, M D T, Ten Eikelder, M L G, de Leeuw, J W, and de Heus, R

Subjects
INDUCED labor (Obstetrics), URINARY catheters, PREMATURE labor, RANDOMIZED controlled trials, BIRTH rate, MISOPROSTOL, RESEARCH, PREMATURE infants, CLINICAL trials, RESEARCH methodology, URINARY catheterization, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, CATHETERS, LONGITUDINAL method
Abstract

Objective: To evaluate the rate of preterm birth (PTB) in a subsequent pregnancy in women who had undergone term induction using a Foley catheter compared with prostaglandins.Methods: This was a follow-up study of two large randomized controlled trials (PROBAAT-1 and PROBAAT-2). In the original trials, women with a term singleton pregnancy with the fetus in cephalic presentation and with an indication for labor induction were randomized to receive either a 30-mL Foley catheter or prostaglandins (vaginal prostaglandin E2 in PROBAAT-1 and oral misoprostol in PROBAAT-2). Data on subsequent ongoing pregnancies > 16 weeks' gestation were collected from hospital charts from clinics participating in this follow-up study. The main outcome measure was preterm birth < 37 weeks' gestation in a subsequent pregnancy.Results: Fourteen hospitals agreed to participate in this follow-up study. Of the 1142 eligible women, 572 had been allocated to induction of labor using a Foley catheter and 570 to induction of labor using prostaglandins. Of these, 162 (14%) were lost to follow-up. In total, 251 and 258 women had a known subsequent pregnancy > 16 weeks' gestation in the Foley catheter and prostaglandin groups, respectively. There were no differences in baseline characteristics between the groups. The overall rate of PTB in a subsequent pregnancy was 9/251 (3.6%) in the Foley catheter group vs 10/258 (3.9%) in the prostaglandin group (relative risk (RR), 0.93; 95% CI, 0.38-2.24), and the rate of spontaneous PTB was 5/251 (2.0%) vs 5/258 (1.9%) (RR, 1.03; 95% CI, 0.30-3.51).Conclusion: In women with term singleton pregnancy, induction of labor using a 30-mL Foley catheter is not associated with an increased risk of PTB in a subsequent pregnancy, as compared to induction of labor using prostaglandins. © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]

Published
2021
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28. Lower frequency of the HLA-G UTR-4 haplotype in women with unexplained recurrent miscarriage

Author

Circulatory Health, CMM Groep Kloosterman, Geboortecentrum voorzitterschap, Meuleman, T, Drabbels, J, van Lith, J M M, Dekkers, O M, Rozemuller, E, Cretu-Stancu, M, Claas, F H J, Bloemenkamp, K W M, Eikmans, M, Circulatory Health, CMM Groep Kloosterman, Geboortecentrum voorzitterschap, Meuleman, T, Drabbels, J, van Lith, J M M, Dekkers, O M, Rozemuller, E, Cretu-Stancu, M, Claas, F H J, Bloemenkamp, K W M, and Eikmans, M

Published
2018

29. Cost-effectiveness of diagnostic testing strategies including cervical-length measurement and fibronectin testing in women with symptoms of preterm labor

Author

van Baaren, G.-J., primary, Vis, J. Y., additional, Wilms, F. F., additional, Oudijk, M. A., additional, Kwee, A., additional, Porath, M. M., additional, Scheepers, H. C. J., additional, Spaanderman, M. E. A., additional, Bloemenkamp, K. W. M., additional, Haak, M. C., additional, Bax, C. J., additional, Cornette, J. M. J., additional, Duvekot, J. J., additional, Nij Bijvanck, B. W. A., additional, van Eyck, J., additional, Franssen, M. T. M., additional, Sollie, K. M., additional, Vandenbussche, F. P. H. A., additional, Woiski, M., additional, Bolte, A. C., additional, van der Post, J. A. M., additional, Bossuyt, P. M. M., additional, Opmeer, B. C., additional, and Mol, B. W. J., additional

Published
2018
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30. A multivariable model to guide the decision for pessary placement to prevent preterm birth in women with a multiple pregnancy: a secondary analysis of the ProTWIN trial

Author

Tajik, P., Monfrance, M., van 't Hooft, J., Liem, S. M. S., Schuit, E., Bloemenkamp, K. W. M., Duvekot, J. J., Nij Bijvank, B., Franssen, M. T. M., Oudijk, M. A., Scheepers, H. C. J., Sikkema, J. M., Woiski, M., Mol, B. W. J., Bekedam, D. J., Bossuyt, P. M., Zafarmand, M. H., Reproductive Origins of Adult Health and Disease (ROAHD), Obstetrie & Gynaecologie, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), RS: GROW - R4 - Reproductive and Perinatal Medicine, Obstetrics & Gynecology, APH - Amsterdam Public Health, ARD - Amsterdam Reproduction and Development, Epidemiology and Data Science, Other departments, Obstetrics and Gynaecology, 10 Public Health & Methodologie, ACS - Amsterdam Cardiovascular Sciences, Other Research, and Public and occupational health

Subjects
pessary, BIOMARKERS, preterm birth, CERVICAL-MUCUS PLUG, treatment selection variable, DELIVERY, comparative effectiveness research, multiple pregnancies, HETEROGENEITY, RECURRENCE, CLINICAL-TRIALS, METAANALYSIS, DICHORIONIC TWIN PREGNANCIES, 17-ALPHA-HYDROXYPROGESTERONE CAPROATE, INTERVENTIONS
Abstract

Objective The ProTWIN Trial (NTR1858) showed that, in women with a multiple pregnancy and a cervical length < 25th percentile (38 mm), prophylactic use of a cervical pessary reduced the risk of adverse perinatal outcome. We investigated whether other maternal or pregnancy characteristics collected at baseline can improve identification of women most likely to benefit from pessary placement. Methods ProTWIN is a multicenter randomized trial in which 808 women with a multiple pregnancy were assigned to pessary or control. Using these data we developed a multivariable logistic model comprising treatment, cervical length, chorionicity, pregnancy history and number of fetuses, and the interaction of these variables with treatment as predictors of adverse perinatal outcome. Results Short cervix, monochorionicity and nulliparity were predictive factors for a benefit from pessary insertion. History of previous preterm birth and triplet pregnancy were predictive factors of possible harm from pessary. The model identified 35% of women as benefiting (95% CI, 32-39%), which is 10% more than using cervical length only (25%) for pessary decisions. The model had acceptable calibration. We estimated that using the model to guide the choice of pessary placement would reduce the risk of adverse perinatal outcome significantly from 13.5% when no pessary is inserted to 8.1% (absolute risk reduction, 5.4% (95% CI, 2.1-8.6%)). Conclusions We developed and internally validated a multivariable treatment selection model, with cervical length, chorionicity, pregnancy history and number of fetuses. If externally validated, it could be used to identify women with a twin pregnancy who would benefit from a pessary, and lead to a reduction in adverse perinatal outcomes in these women. Copyright (C) 2016 ISUOG. Published by John Wiley & Sons Ltd.

Published
2016

31. Prediction of Time to Delivery Week-by-Week in Women with a Triplet Pregnancy

Author

van de Mheen, L, Ravelli, A C, Oudijk, M A, Bijvank, S Nij, Porath, M M, Duvekot, J J, Scholtenhuis, M A G Holswilder-Olde, Bloemenkamp, K W M, Scheepers, H C J, Woiski, M, Pampus, M G van, Groot, C J de, Pajkrt, E, Mol, B W J, van de Mheen, L, Ravelli, A C, Oudijk, M A, Bijvank, S Nij, Porath, M M, Duvekot, J J, Scholtenhuis, M A G Holswilder-Olde, Bloemenkamp, K W M, Scheepers, H C J, Woiski, M, Pampus, M G van, Groot, C J de, Pajkrt, E, and Mol, B W J

Published
2016

33. Maintenance tocolysis with nifedipine in threatened preterm labour : 2-year follow up of the offspring in the APOSTEL II trial

Author

van Vliet, E.O.G., Seinen, L., Roos, C., Schuit, E., Scheepers, H. C J, Bloemenkamp, K. W M, Duvekot, J. J., van Eyck, J., Kok, J. H., Lotgering, F. K., van Baar, A., van Wassenaer-Leemhuis, A. G., Franssen, M. T., Porath, M. M., van der Post, J. A M, Franx, A., Mol, B. W J, Oudijk, M. A., van Vliet, E.O.G., Seinen, L., Roos, C., Schuit, E., Scheepers, H. C J, Bloemenkamp, K. W M, Duvekot, J. J., van Eyck, J., Kok, J. H., Lotgering, F. K., van Baar, A., van Wassenaer-Leemhuis, A. G., Franssen, M. T., Porath, M. M., van der Post, J. A M, Franx, A., Mol, B. W J, and Oudijk, M. A.

Published
2016

36. Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial

Author

MS Verloskunde, Epi Methoden Team 1, DV&B-MT-Medisch, Brain, Circulatory Health, Child Health, Other research (not in main researchprogram), van Vliet, E.O.G., Seinen, L., Roos, C., Schuit, E., Scheepers, H. C J, Bloemenkamp, K. W M, Duvekot, J. J., van Eyck, J., Kok, J. H., Lotgering, F. K., van Baar, A., van Wassenaer-Leemhuis, A. G., Franssen, M. T., Porath, M. M., van der Post, J. A M, Franx, A., Mol, B. W J, Oudijk, M. A., MS Verloskunde, Epi Methoden Team 1, DV&B-MT-Medisch, Brain, Circulatory Health, Child Health, Other research (not in main researchprogram), van Vliet, E.O.G., Seinen, L., Roos, C., Schuit, E., Scheepers, H. C J, Bloemenkamp, K. W M, Duvekot, J. J., van Eyck, J., Kok, J. H., Lotgering, F. K., van Baar, A., van Wassenaer-Leemhuis, A. G., Franssen, M. T., Porath, M. M., van der Post, J. A M, Franx, A., Mol, B. W J, and Oudijk, M. A.

Published
2016

38. Second-trimester cervical length as risk indicator for Cesarean delivery in women with twin pregnancy

Author

van de Mheen, L, Schuit, E, Liem, S M S, Lim, A C, Bekedam, D J, Goossens, S M T A, Franssen, M T M, Porath, M M, Oudijk, M A, Bloemenkamp, K W M, Duvekot, J J, Woiski, M D, de Graaf, I, Sikkema, J M, Scheepers, H C J, van Eijk, J, de Groot, C J M, van Pampus, M G, Mol, B W J, van de Mheen, L, Schuit, E, Liem, S M S, Lim, A C, Bekedam, D J, Goossens, S M T A, Franssen, M T M, Porath, M M, Oudijk, M A, Bloemenkamp, K W M, Duvekot, J J, Woiski, M D, de Graaf, I, Sikkema, J M, Scheepers, H C J, van Eijk, J, de Groot, C J M, van Pampus, M G, and Mol, B W J

Published
2015

39. Effect of levothyroxine on live birth rate in euthyroid women with recurrent miscarriage and TPO antibodies (T4-LIFE study)

Author

Vissenberg, R., van Dijk, M. M., Fliers, E., van der Post, J. A M, van Wely, M., Bloemenkamp, K. W M, Hoek, A., Kuchenbecker, W. K., Verhoeve, H. R., Scheepers, H. C J, Rombout-de Weerd, S., Koks, C., Zwart, J. J., Broekmans, F., Verpoest, W., Christiansen, O. B., Post, M., Papatsonis, D. N M, Verberg, M. F G, Sikkema, J., Mol, B. W., Bisschop, P. H., Goddijn, M., Vissenberg, R., van Dijk, M. M., Fliers, E., van der Post, J. A M, van Wely, M., Bloemenkamp, K. W M, Hoek, A., Kuchenbecker, W. K., Verhoeve, H. R., Scheepers, H. C J, Rombout-de Weerd, S., Koks, C., Zwart, J. J., Broekmans, F., Verpoest, W., Christiansen, O. B., Post, M., Papatsonis, D. N M, Verberg, M. F G, Sikkema, J., Mol, B. W., Bisschop, P. H., and Goddijn, M.

Published
2015

40. Effect of levothyroxine on live birth rate in euthyroid women with recurrent miscarriage and TPO antibodies (T4-LIFE study)

Author

Project Ondersteuning, Geboortecentrum voorzitterschap, MS VPG/Gynaecologie, Circulatory Health, Child Health, Cardiologie, Vissenberg, R., van Dijk, M. M., Fliers, E., van der Post, J. A M, van Wely, M., Bloemenkamp, K. W M, Hoek, A., Kuchenbecker, W. K., Verhoeve, H. R., Scheepers, H. C J, Rombout-de Weerd, S., Koks, C., Zwart, J. J., Broekmans, F., Verpoest, W., Christiansen, O. B., Post, M., Papatsonis, D. N M, Verberg, M. F G, Sikkema, J., Mol, B. W., Bisschop, P. H., Goddijn, M., Project Ondersteuning, Geboortecentrum voorzitterschap, MS VPG/Gynaecologie, Circulatory Health, Child Health, Cardiologie, Vissenberg, R., van Dijk, M. M., Fliers, E., van der Post, J. A M, van Wely, M., Bloemenkamp, K. W M, Hoek, A., Kuchenbecker, W. K., Verhoeve, H. R., Scheepers, H. C J, Rombout-de Weerd, S., Koks, C., Zwart, J. J., Broekmans, F., Verpoest, W., Christiansen, O. B., Post, M., Papatsonis, D. N M, Verberg, M. F G, Sikkema, J., Mol, B. W., Bisschop, P. H., and Goddijn, M.

Published
2015

41. Second-trimester cervical length as risk indicator for Cesarean delivery in women with twin pregnancy

Author

Epi Methoden Team 1, Other research (not in main researchprogram), Geboortecentrum voorzitterschap, van de Mheen, L, Schuit, E, Liem, S M S, Lim, A C, Bekedam, D J, Goossens, S M T A, Franssen, M T M, Porath, M M, Oudijk, M A, Bloemenkamp, K W M, Duvekot, J J, Woiski, M D, de Graaf, I, Sikkema, J M, Scheepers, H C J, van Eijk, J, de Groot, C J M, van Pampus, M G, Mol, B W J, Epi Methoden Team 1, Other research (not in main researchprogram), Geboortecentrum voorzitterschap, van de Mheen, L, Schuit, E, Liem, S M S, Lim, A C, Bekedam, D J, Goossens, S M T A, Franssen, M T M, Porath, M M, Oudijk, M A, Bloemenkamp, K W M, Duvekot, J J, Woiski, M D, de Graaf, I, Sikkema, J M, Scheepers, H C J, van Eijk, J, de Groot, C J M, van Pampus, M G, and Mol, B W J

Published
2015

42. Cost-effectiveness of induction of labour at term with a Foley catheter compared to vaginal prostaglandin E₂ gel (PROBAAT trial)

Author

van Baaren, G. J., Jozwiak, M., Opmeer, B. C., Oude Rengerink, K., Benthem, M., Dijksterhuis, M. G. K., van Huizen, M. E., van der Salm, P. C. M., Schuitemaker, N. W. E., Papatsonis, D. N. M., Perquin, D. A. M., Porath, M., van der Post, J. A. M., Rijnders, R. J. P., Scheepers, H. C. J., Spaanderman, M., van Pampus, M. G., de Leeuw, J. W., Mol, B. W. J., Bloemenkamp, K. W. M., Other departments, Clinical Research Unit, ARD - Amsterdam Reproduction and Development, Obstetrics and Gynaecology, and APH - Amsterdam Public Health

Subjects
reproductive and urinary physiology
Abstract

To assess the economic consequences of labour induction with Foley catheter compared to prostaglandin E2 gel. Economic evaluation alongside a randomised controlled trial. Obstetric departments of one university and 11 teaching hospitals in the Netherlands. Women scheduled for labour induction with a singleton pregnancy in cephalic presentation at term, intact membranes and an unfavourable cervix; and without previous caesarean section. Cost-effectiveness analysis from a hospital perspective. We estimated direct medical costs associated with healthcare utilisation from randomisation to 6 weeks postpartum. For caesarean section rate, and maternal and neonatal morbidity we calculated the incremental cost-effectiveness ratios, which represent the costs to prevent one of these adverse outcomes. Mean costs per woman in the Foley catheter group (n = 411) and in the prostaglandin E₂ gel group (n = 408), were €3297 versus €3075, respectively, with an average difference of €222 (95% confidence interval -€157 to €633). In the Foley catheter group we observed higher costs due to longer labour ward occupation and less cost related to induction material and neonatal admissions. Foley catheter induction showed a comparable caesarean section rate compared with prostaglandin induction, therefore the incremental cost-effectiveness ratio was not informative. Foley induction resulted in fewer neonatal admissions (incremental cost-effectiveness ratio €2708) and asphyxia/postpartum haemorrhage (incremental cost-effectiveness ratios €5257) compared with prostaglandin induction. Foley catheter and prostaglandin E2 labour induction generate comparable costs

Published
2013

43. Comparing induction of labour with oral misoprostol or Foley catheter at term: cost-effectiveness analysis of a randomised controlled multi-centre non-inferiority trial.

Author

ten Eikelder, M. L. G., van Baaren, G‐J, Oude Rengerink, K., Jozwiak, M., de Leeuw, J. W., Kleiverda, G., Evers, I., de Boer, K., Brons, J., Bloemenkamp, K. W. M., Mol, B. W., Ten Eikelder, Mlg, van Baaren, G-J, and Bloemenkamp, Kwm

Subjects
MISOPROSTOL, URINARY catheters, INDUCED labor (Obstetrics), COST effectiveness, HEALTH outcome assessment, OXYTOCICS, CATHETERIZATION, CERVIX uteri, COMPARATIVE studies, DELIVERY (Obstetrics), LABOR (Obstetrics), RESEARCH methodology, MEDICAL cooperation, ORAL drug administration, THIRD trimester of pregnancy, RESEARCH, EVALUATION research, RANDOMIZED controlled trials, TREATMENT effectiveness, THERAPEUTICS
Abstract

Objective: To assess the costs of labour induction with oral misoprostol versus Foley catheter.Design: Economic evaluation alongside a randomised controlled trial.Setting: Obstetric departments of six tertiary and 23 secondary care hospitals in the Netherlands.Population: Women with a viable term singleton pregnancy in cephalic presentation, intact membranes, an unfavourable cervix (Bishop score <6) without a previous caesarean section, were randomised for labour induction with oral misoprostol (n = 924) or Foley catheter (n = 921).Methods: We performed economic analysis from a hospital perspective. We estimated direct medical costs associated with healthcare utilisation from randomisation until discharge. The robustness of our findings was evaluated in sensitivity analyses.Main Outcome Measures: Mean costs and differences were calculated per women induced with oral misoprostol or Foley catheter.Results: Mean costs per woman in the oral misoprostol group and Foley catheter group were €4470 versus €4158, respectively [mean difference €312, 95% confidence interval (CI) -€508 to €1063]. Multiple sensitivity analyses did not change these conclusions. However, if cervical ripening for low-risk pregnancies in the Foley catheter group was carried out in an outpatient setting, with admittance to labour ward only at start of active labour, the difference would be €4470 versus €3489, respectively (mean difference €981, 95% CI €225-1817).Conclusions: Oral misoprostol and Foley catheter generate comparable costs. Cervical ripening outside labour ward with a Foley catheter could potentially save almost €1000 per woman.Tweetable Abstract: Oral misoprostol or Foley catheter for induction of labour generates comparable costs. [ABSTRACT FROM AUTHOR]

Published
2018
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44. Foleykatheter versus prostaglandine E2-gel voor inleiden van aterme baring

Author

Jozwiak, M., Oude Rengerink, K., de Leeuw, J. W., Mol, B. W. J., Bloemenkamp, K. W. M., Benthem, M., van Beek, E., Dijksterhuis, M. G. K., de Graaf, I. M., van Huizen, M. E., Oudijk, M. A., Papatsonis, D. N. M., Perquin, D. A. M., Porath, M., van der Post, J. A. M., Rijnders, R. J. P., Scheepers, H. C. J., Spaanderman, M. E. A., van Pampus, M. G., Amsterdam Public Health, Obstetrics and Gynaecology, Other Research, and Amsterdam Reproduction & Development (AR&D)

Abstract

OBJECTIVE : To study the effectiveness and safety of induction of labour with a Foley catheter compared with vaginal prostaglandin E2 gel in full term pregnant women. DESIGN : Multicentre, randomised, open-label trial in 12 hospitals in the Netherlands between February 2009 and May 2010. METHODS : Women scheduled for induction of labour at full term singleton pregnancy in cephalic presentation, intact membranes, and an unripe cervix (Bishop score < 6) were enrolled by means of an on-line system. Participants were randomly allocated to induction of labour with a transcervical Foley catheter or vaginal prostaglandin E2 gel. The primary outcome was caesarean section rate. Secondary outcomes were maternal and neonatal morbidity and time from induction to birth. RESULTS : A total of 824 women were allocated to induction of labour with a Foley catheter (n = 412) or prostaglandin E2 (n = 412). Caesarean section rates were comparable (23% versus 20%, RR 1.13, 95% CI 0.87 to 1.47). In the Foley catheter group fewer instrumental deliveries for foetal distress were performed (12% versus 18%, RR 0.68, 95% CI 0.49 to 0.95). Time to delivery (median hours (IQR)) was longer (29 (15-35) versus 18 (12-33)). Fewer mothers had suspected intrapartum infection (2% versus 4%, RR 0.41, 95% CI 0.17-0.98). Significantly fewer neonates were admitted toaneonatal ward after induction with a Foley catheter (12% versus 20%, RR 0.60, 95% CI 0.43 to 0.83). CONCLUSION : In women with an unripe cervix at term, induction of labour with a Foley catheter does not reduce caesarean section rates, but there are fewer side-effects

Published
2012

46. Liever inleiden dan afwachten bij aterme zwangerschapshypertensie en milde preëclampsie: HYPITAT-studie*

Author

Koopmans, C. M., Bijlenga, D., Groen, H., Vijgen, S. M. C., Aarnoudse, J. G., Bekedam, D. J., van den Berg, P. P., de Boer, K., Burggraaff, J. M., Bloemenkamp, K. W. M., Drogtrop, A. P., Franx, A., de Groot, C. J. M., Huisjes, A. J. M., Kwee, A., van Loon, A. J., Lub, A., Papatsonis, D. N. M., van der Post, J. A. M., Roumen, F. J. M. E., Scheepers, H. C. J., Willekes, C., Mol, B. W. J., van Pampus, M. G., Obstetrics and gynaecology, ICaR - Ischemia and repair, Science in Healthy Ageing & healthcaRE (SHARE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Reproductive Origins of Adult Health and Disease (ROAHD), Other departments, Amsterdam Reproduction & Development (AR&D), Obstetrics and Gynaecology, and Amsterdam Public Health

Subjects
reproductive and urinary physiology
Abstract

OBJECTIVE: To investigate what would benefit women with mild full-term pregnancy-related hypertension most: induction of labour or expectant monitoring, from the perspective of clinical effectiveness, maternal quality of life, and costs. DESIGN: Randomised clinical trial. Trial registration number ISRCTN08132825. METHODS: We undertook a multicentre randomised controlled trial in 38 hospitals in the Netherlands between October 2005 and March 2008. We enrolled patients with a singleton pregnancy in cephalic presentation at 36-41 weeks' gestation, who had gestational hypertension or mild preeclampsia. Participants were randomly allocated to receive either induction of labour or expectant monitoring. The primary outcome was a composite measure of poor maternal outcome, defined as maternal mortality, maternal morbidity (eclampsia, 'haemolysis, elevated liver enzymes, low platelets' (HELLP) syndrome, pulmonary oedema, thrombo-embolic disease and abruptio placentae), progression to severe hypertension or proteinuria, and major postpartum haemorrhage. Secondary outcomes were mode of delivery, neonatal outcome, maternal quality of life and costs. Analysis was by intention to treat. RESULTS: A total of 756 patients were allocated to receive induction of labour (n = 377 patients) or expectant monitoring (n = 379). No cases of maternal or neonatal death or eclampsia were recorded. Development of poor maternal outcome was significantly lower in the induction of labour group (117 women) than the expectant monitoring group (166 women) (31% versus 44%; relative risk 0.71 (95% CI: 0.59-0.86); p < 0.001). The caesarean section rate was lower among women in the induction of labour group (n = 54) compared to women in the expectant monitoring group (n = 72) (14% versus 19%; relative risk 0.75 (95% CI: 0.55-1.04)< p = 0.085). Neonatal outcomes and quality of life were comparable between both groups. Induction of labour is a cost saving strategy (difference euro 831). CONCLUSION: For women with full-term gestational hypertension and pre-eclampsia, induction of labour is associated with improved maternal outcome and lower costs, without the additional risk of a caesarean section being necessary

Published
2010

48. Prediction of Time to Delivery Week-by-Week in Women with a Triplet Pregnancy.

Author

van de Mheen, L., Ravelli, A. C., Oudijk, M. A., Bijvank, S. Nij, Porath, M. M., Duvekot, J. J., Holswilder-Olde Scholtenhuis, M. A. G., Bloemenkamp, K. W. M., Scheepers, H. C. J., Woiski, M., van Pampus, M. G., de Groot, C. J., Pajkrt, E., and Mol, B. W. J.

Subjects
RISK factors in premature labor, ADRENOCORTICAL hormones, HORMONE therapy, DELIVERY (Obstetrics), GESTATIONAL age, HOSPITAL care, LUNGS, MULTIPLE pregnancy, TIME, DESCRIPTIVE statistics, FETUS, PREGNANCY
Abstract

Objective Some clinicians advise prophylactic administration of antenatal steroids for fetal lung maturation in women with a triplet pregnancy. However, the effect of corticosteroids is limited to 10 to 14 days after administration. The aim of this study was to assess the natural course of triplet pregnancies to allow a better anticipation for administration of corticosteroids. Study Design We collected data on all triplet pregnancies in the Netherlands from 1999 to 2007 from the Netherlands Perinatal Registration. We calculated time to delivery, the risk of delivery in 2-week intervals at different gestational ages, and the time frame between hospital admission and delivery of the first child. Results Median gestational age at delivery of 494 women with a triplet pregnancy was 33+4 weeks (interquartile range of 31-35+1 weeks). Twenty-one women (4.3%) delivered between 22 and 24 weeks and 146 women (29.6%) delivered before 32 weeks. At a gestational age of 24 weeks, the chance to deliver within the next week was 0.6%. For 26, 28, 30, 31, and 32 weeks, these risks were 2.4, 2.5, 8.1, 7, and 16.7%, respectively. Conclusion Before 32 weeks of gestation, prophylactic administration of steroids is not indicated as the risk to deliver within 7 days is < 10%. [ABSTRACT FROM AUTHOR]

Published
2016
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49. Genetic Variants in Pre-Eclampsia

Author

Buurma, A. J., primary, Turner, R. J., additional, Driessen, J. H. M., additional, Mooyaart, A. L., additional, Schoones, J. W., additional, Bruijn, J. A., additional, Bloemenkamp, K. W. M., additional, Dekkers, O. M., additional, and Baelde, H. J., additional

Published
2013
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