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1. Nationwide quality assurance of high-throughput diagnostic molecular testing during the SARS-CoV-2 pandemic: role of the Belgian National Reference Centre

Author

Janssen, Reile, Cuypers, Lize, Laenen, Lies, Keyaerts, Els, Beuselinck, Kurt, Janssenswillen, Sunita, Slechten, Bram, Bode, Jannes, Wollants, Elke, Van Laethem, Kristel, Rector, Annabel, Bloemen, Mandy, Sijmons, Anke, de Schaetzen, Nathalie, Capron, Arnaud, Van Baelen, Kurt, Pascal, Thierry, Vermeiren, Céline, Bureau, Fabrice, Vandesompele, Jo, De Smet, Pieter, Uten, Wouter, Malonne, Hugues, Kerkhofs, Pierre, De Cock, Jo, Matheeussen, Veerle, Verhasselt, Bruno, Gillet, Laurent, Detry, Gautier, Bearzatto, Bertrand, Degosserie, Jonathan, Henin, Coralie, Pairoux, Gregor, Maes, Piet, Van Ranst, Marc, Lagrou, Katrien, Dequeker, Elisabeth, and André, Emmanuel

Published
2024
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2. Respiratory Viruses in Wastewater Compared with Clinical Samples, Leuven, Belgium

Author

Rector, Annabel, Bloemen, Mandy, Thijssen, Marijn, Pussig, Bram, Beuselinck, Kurt, Van Ranst, Marc, and Wollants, Elke

Subjects
Lung diseases -- Comparative analysis -- Health aspects, Wastewater -- Comparative analysis -- Health aspects, Influenza -- Health aspects -- Comparative analysis, Water treatment plants -- Health aspects -- Comparative analysis, Sewage -- Purification, Health
Abstract

Since the COVID-19 pandemic began, wastewater-based surveillance has been used to track circulation levels of SARS-CoV-2 (1,2). For that purpose, we began collecting samples from a regional wastewater treatment plant [...]

Published
2024
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4. Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021–2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study.

Author

Simoes, Margarida Pires, Hodcroft, Emma B, Simmonds, Peter, Albert, Jan, Alidjinou, Enagnon K, Ambert-Balay, Katia, Andrés, Cristina, Antón, Andrés, Auvray, Christelle, Bailly, Jean-Luc, Baldanti, Fausto, Bastings, Capser, Beard, Stuart, Berengua, Carla, Berginc, Natasa, Bloemen, Mandy, Blomqvist, Soile, Bosma, Froukje, Böttcher, Sindy, and Bubba, Laura

Subjects
RESPIRATORY diseases, MYELITIS, RESPIRATORY infections, ACUTE diseases, FEVER, ENTEROVIRUS diseases
Abstract

Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021–2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0–5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021/22 and the emergence of novel B3-derived lineages, ENPEN multicentre study

Author

Simoes, Margarida Pires, primary, Hodcroft, Emma B, additional, Simmonds, Peter, additional, Albert, Jan, additional, Alidjinou, Enagon K, additional, Ambert-Balay, Katia, additional, Andrés, Cristina, additional, Antón, Andrés, additional, Auvray, Christelle, additional, Bailly, Jean-Luc, additional, Baldanti, Fausto, additional, Bastings, Capser, additional, Beard, Stuart, additional, Pereira, Carla Berengua, additional, Berginc, Natasa, additional, Bloemen, Mandy, additional, Blomqvist, Soile, additional, Bosma, Froukje, additional, Böttcher, Sindy, additional, Bubba, Laura, additional, Buderus, Stafan, additional, Cabrerizo, Maria, additional, Calvo, Christina, additional, Celma, Christina, additional, Ceriotti, Ferruccio, additional, Clark, Gemma, additional, Costa, Inës, additional, Coste-Burel, Marianne, additional, Couderé, Karen, additional, Cremer, Jeroen, additional, del Cuerpo Casas, Margarita, additional, Daehne, Theo, additional, de Beer, Jessica, additional, de Ceano-Vivas, Maria, additional, De Gascun, Cillian, additional, de Rougemont, Alexis, additional, Dean, Johnathan, additional, Dembinski, Jennifer L, additional, Diedrich, Sabine, additional, Diez-Domingo, Javier, additional, Dillner, Lena, additional, Dorenberg, Dagny H, additional, Ducancelle, Alexandra, additional, Dudman, Susanne, additional, Dyrdak, Robert, additional, Eis-Huebinger, Anna-Maria, additional, Falces-Romero, Iker, additional, Farkas, Agnes, additional, Feeney, Susan, additional, Fernandez-Garcia, Maria D, additional, Flipse, Jacky, additional, Franck, Kristina T, additional, Galli, Cristina, additional, Garrigue, Isabelle, additional, Geeraedts, Felix, additional, Georgieva, Irina, additional, Giardina, Federica, additional, Guiomar, Raquel, additional, Hauzenberger, Elenor, additional, Heikens, Esther, additional, Henquell, Cécille, additional, Hober, Didier, additional, Hönemann, Amrio, additional, Howson-Wells, Hannah, additional, Hruškar, Željka, additional, Ikonen, Niina, additional, Imbert, Berthemarie, additional, Jansz, Arjan R, additional, Jeannoël, Marion, additional, Jiřincová, Helena, additional, Josset, Laurence, additional, Keeren, Kathrin, additional, Kramer-Lindhout, Naomie, additional, Krokstad, Sidsel, additional, Lazrek, Mouna, additional, Le Guillou-Guillemette, Hélène, additional, Lefeuvre, Caroline, additional, Lind, Andreas, additional, Lunar, Maja M, additional, Maier, Melanie, additional, Marque-Juillet, Stéphanie, additional, McClure, C Patrick, additional, McKenna, James, additional, Meijer, Adam, additional, Menasalvas Ruiz, Ana, additional, Mengual-Chuliá, Beatriz, additional, Midgley, Sofie, additional, Mirand, Audrey, additional, Molenkamp, Richard, additional, Montes, Milagrosa, additional, Moreno-Docón, Antonio, additional, Morley, Ursula, additional, Murk, Jean-Luc, additional, Navascués-Ortega, Ana, additional, Nijhuis, Roel, additional, Nikolaeva-Glomb, Lubomira, additional, Nordbø, Svein A, additional, Numanovic, Sanela, additional, Oggioni, Massimo, additional, Oñate Vergara, Eider, additional, Pacaud, Jordi, additional, Pacreau, Marie L, additional, Panning, Marcus, additional, Pariani, Elena, additional, Pekova, Lili, additional, Pellegrinelli, Laura, additional, Petrovec, Miroslav, additional, Pietsch, Corinna, additional, Pilorge, Léa, additional, Piñeiro, Luis, additional, Piralla, Antonio, additional, Poljak, Mario, additional, Prochazka, Birgit, additional, Rabella, Nuria, additional, Rahamat-Langendoen, Janette C, additional, Rainetova, petra, additional, Reynders, Marijke, additional, Riezebos-Brilman, Annelies, additional, Roorda, Lieuwe, additional, Savolainen-Kopra, Carita, additional, Schuffenecker, Isabelle, additional, Smeets, Leo C, additional, Stoyanova, Ayse, additional, Stefic, Karl, additional, Swanink, Caroline, additional, Tabain, Irena, additional, Tjhie, Jeroen, additional, Thouault, Luc, additional, Tumiotto, Camille, additional, Uceda Renteria, Sara, additional, Uršič, Tina, additional, Vallet, Sophie, additional, Van Ranst, Marc, additional, Van Wunnik, Peter, additional, Verweij, Jaco J, additional, Vila, Jorgina, additional, Wintermans, Bas, additional, Wollants, Elke, additional, Wolthers, Katja C, additional, Xavier López-Labrado, F, additional, Fischer, Thea Kolsen, additional, Harvala, Heli, additional, and Benschop, Kimberley S M, additional

Published
2024
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10. Immunovirological and environmental screening reveals actionable risk factors for fatal COVID-19 during post-vaccination nursing home outbreaks.

Author

Cuypers, Lize, Keyaerts, Els, Hong, Samuel Leandro, Gorissen, Sarah, Menezes, Soraya Maria, Starick, Marick, Van Elslande, Jan, Weemaes, Matthias, Wawina-Bokalanga, Tony, Marti-Carreras, Joan, Vanmechelen, Bert, Van Holm, Bram, Bloemen, Mandy, Dogne, Jean-Michel, Dufrasne, François, Durkin, Keith, Ruelle, Jean, De Mendonça, Ricardo, Wollants, Elke, Vermeersch, Pieter, COVID-19 Genomics Belgium Consortium, Boulouffe, Caroline, Djiena, Achille, Broucke, Caroline, Catry, Boudewijn, Lagrou, Katrien, Van Ranst, Marc, Neyts, Johan, Baele, Guy, Maes, Piet, André, Emmanuel, Dellicour, Simon, Van Weyenbergh, Johan, Cuypers, Lize, Keyaerts, Els, Hong, Samuel Leandro, Gorissen, Sarah, Menezes, Soraya Maria, Starick, Marick, Van Elslande, Jan, Weemaes, Matthias, Wawina-Bokalanga, Tony, Marti-Carreras, Joan, Vanmechelen, Bert, Van Holm, Bram, Bloemen, Mandy, Dogne, Jean-Michel, Dufrasne, François, Durkin, Keith, Ruelle, Jean, De Mendonça, Ricardo, Wollants, Elke, Vermeersch, Pieter, COVID-19 Genomics Belgium Consortium, Boulouffe, Caroline, Djiena, Achille, Broucke, Caroline, Catry, Boudewijn, Lagrou, Katrien, Van Ranst, Marc, Neyts, Johan, Baele, Guy, Maes, Piet, André, Emmanuel, Dellicour, Simon, and Van Weyenbergh, Johan

Abstract

Coronavirus Disease 2019 (COVID-19) vaccination has resulted in excellent protection against fatal disease, including in older adults. However, risk factors for post-vaccination fatal COVID-19 are largely unknown. We comprehensively studied three large nursing home outbreaks (20-35% fatal cases among residents) by combining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) aerosol monitoring, whole-genome phylogenetic analysis and immunovirological profiling of nasal mucosa by digital nCounter transcriptomics. Phylogenetic investigations indicated that each outbreak stemmed from a single introduction event, although with different variants (Delta, Gamma and Mu). SARS-CoV-2 was detected in aerosol samples up to 52 d after the initial infection. Combining demographic, immune and viral parameters, the best predictive models for mortality comprised IFNB1 or age, viral ORF7a and ACE2 receptor transcripts. Comparison with published pre-vaccine fatal COVID-19 transcriptomic and genomic signatures uncovered a unique IRF3 low/IRF7 high immune signature in post-vaccine fatal COVID-19 outbreaks. A multi-layered strategy, including environmental sampling, immunomonitoring and early antiviral therapy, should be considered to prevent post-vaccination COVID-19 mortality in nursing homes., 0, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

11. Monitoring of SARS‐CoV‐2 concentration and circulation of variants of concern in wastewater of Leuven, Belgium

Author

Rector, Annabel, primary, Bloemen, Mandy, additional, Thijssen, Marijn, additional, Delang, Leen, additional, Raymenants, Joren, additional, Thibaut, Jonathan, additional, Pussig, Bram, additional, Fondu, Lore, additional, Aertgeerts, Bert, additional, Van Ranst, Marc, additional, Van Geet, Chris, additional, Arnout, Jef, additional, and Wollants, Elke, additional

Published
2023
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12. Immunovirological and environmental screening reveals actionable risk factors for fatal COVID-19 during post-vaccination nursing home outbreaks

Author

COVID-19 Genomics Belgium Consortium, Cuypers, Lize, Keyaerts, Els, Hong, Samuel Leandro, Gorissen, Sarah, Menezes, Soraya Maria, Starick, Marick, Van Elslande, Jan, Weemaes, Matthias, Wawina-Bokalanga, Tony, Marti-Carreras, Joan, Vanmechelen, Bert, Van Holm, Bram, Bloemen, Mandy, Dogné, Jean-Michel, Dufrasne, François, Durkin, Keith, Ruelle, Jean, De Mendonca, Ricardo, Wollants, Elke, Vermeersch, Pieter, Boulouffe, Caroline, Djiena, Achille, Broucke, Caroline, Catry, Boudewijn, Lagrou, Katrien, Van Ranst, Marc, Neyts, Johan, Baele, Guy, Maes, Piet, André, Emmanuel, Dellicour, Simon, Van Weyenbergh, Johan, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, Supporting clinical sciences, Microbiology and Infection Control, and Clinical Biology

Subjects
Epidemiology, SARS-CoV-2, Vaccination, Immunovirological screening, COVID-19, infectious diseases, Nursing Homes, Disease Outbreaks, Immunology and Microbiology(all), Virology, environmental screening, Humans, Genetics(clinical), post-vaccination, Phylogeny, nursing home outbreaks, Aged
Abstract

Coronavirus Disease 2019 (COVID-19) vaccination has resulted in excellent protection against fatal disease, including in older adults. However, risk factors for post-vaccination fatal COVID-19 are largely unknown. We comprehensively studied three large nursing home outbreaks (20-35% fatal cases among residents) by combining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) aerosol monitoring, whole-genome phylogenetic analysis and immunovirological profiling of nasal mucosa by digital nCounter transcriptomics. Phylogenetic investigations indicated that each outbreak stemmed from a single introduction event, although with different variants (Delta, Gamma and Mu). SARS-CoV-2 was detected in aerosol samples up to 52 d after the initial infection. Combining demographic, immune and viral parameters, the best predictive models for mortality comprised IFNB1 or age, viral ORF7a and ACE2 receptor transcripts. Comparison with published pre-vaccine fatal COVID-19 transcriptomic and genomic signatures uncovered a unique IRF3 low/IRF7 high immune signature in post-vaccine fatal COVID-19 outbreaks. A multi-layered strategy, including environmental sampling, immunomonitoring and early antiviral therapy, should be considered to prevent post-vaccination COVID-19 mortality in nursing homes.

Published
2023

17. Environmental circulation of adenovirus 40/41 and SARS-CoV-2 in the context of the emergence of acute hepatitis of unknown origin

Author

Wollants, Elke, primary, Keyaerts, Els, additional, Cuypers, Lize, additional, Bloemen, Mandy, additional, Thijssen, Marijn, additional, Ombelet, Sien, additional, Raymenants, Joren, additional, Beuselinck, Kurt, additional, Laenen, Lies, additional, Budts, Lore, additional, Pussig, Bram, additional, Lagrou, Katrien, additional, Van Ranst, Marc, additional, and André, Emmanuel, additional

Published
2022
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19. Detection Of SARS-COV-2 Variants Of Concern In Wastewater Of Leuven, Belgium

Author

Bloemen, Mandy, primary, Delang, Leen, additional, Rector, Annabel, additional, Raymenants, Joren, additional, Thibaut, Jonathan, additional, Pussig, Bram, additional, Fondu, Lore, additional, Aertgeerts, Bert, additional, Van Ranst, Marc, additional, Van Geet, Chris, additional, Arnout, Jef, additional, and Wollants, Elke, additional

Published
2022
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22. Two Separate Clusters of SARS-CoV-2 Delta Variant Infections in a Group of 41 Students Travelling from India: An Illustration of the Need for Rigorous Testing and Quarantine.

Author

Van Elslande, Jan, Kerckhofs, Femke, Cuypers, Lize, Wollants, Elke, Potter, Barney, Vankeerberghen, Anne, Cattoir, Lien, Holderbeke, Astrid, Behillil, Sylvie, Gorissen, Sarah, Bloemen, Mandy, Arnout, Jef, Van Ranst, Marc, Van Weyenbergh, Johan, Maes, Piet, Baele, Guy, Vermeersch, Pieter, and André, Emmanuel

Subjects
SARS-CoV-2 Delta variant, STUDENT travel, VACCINATION status, QUARANTINE, INFECTIOUS disease transmission
Abstract

We report two clusters of SARS-CoV-2 B.1.617.2 (Delta variant) infections in a group of 41 Indian nursing students who travelled from New Delhi, India, to Belgium via Paris, France. All students tested negative before departure and had a second negative antigen test upon arrival in Paris. Upon arrival in Belgium, the students were quarantined in eight different houses. Four houses remained COVID-free during the 24 days of follow-up, while all 27 residents of the other four houses developed an infection during quarantine, including the four residents who were fully vaccinated and the two residents who were partially vaccinated. Genome sequencing revealed two distinct clusters affecting one and three houses, respectively. In this group of students, vaccination status did not seem to prevent infection nor decrease the viral load. No severe symptoms were reported. Extensive contact tracing and 3 months of nationwide genomic surveillance confirmed that these outbreaks were successfully contained and did not contribute to secondary community transmission in Belgium. These clusters highlight the importance of repeated testing and quarantine measures among travelers coming from countries experiencing a surge of infections, as all infections were detected 6 days or more after arrival. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Immunovirological and environmental screening reveals actionable risk factors for fatal COVID-19 during post-vaccination nursing home outbreaks.

Author

Cuypers L, Keyaerts E, Hong SL, Gorissen S, Menezes SM, Starick M, Van Elslande J, Weemaes M, Wawina-Bokalanga T, Marti-Carreras J, Vanmechelen B, Van Holm B, Bloemen M, Dogne JM, Dufrasne F, Durkin K, Ruelle J, De Mendonca R, Wollants E, Vermeersch P, Boulouffe C, Djiena A, Broucke C, Catry B, Lagrou K, Van Ranst M, Neyts J, Baele G, Maes P, André E, Dellicour S, and Van Weyenbergh J

Subjects
Humans, Aged, Phylogeny, SARS-CoV-2 genetics, Nursing Homes, Vaccination, Disease Outbreaks prevention & control, COVID-19 epidemiology
Abstract

Coronavirus Disease 2019 (COVID-19) vaccination has resulted in excellent protection against fatal disease, including in older adults. However, risk factors for post-vaccination fatal COVID-19 are largely unknown. We comprehensively studied three large nursing home outbreaks (20-35% fatal cases among residents) by combining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) aerosol monitoring, whole-genome phylogenetic analysis and immunovirological profiling of nasal mucosa by digital nCounter transcriptomics. Phylogenetic investigations indicated that each outbreak stemmed from a single introduction event, although with different variants (Delta, Gamma and Mu). SARS-CoV-2 was detected in aerosol samples up to 52 d after the initial infection. Combining demographic, immune and viral parameters, the best predictive models for mortality comprised IFNB1 or age, viral ORF7a and ACE2 receptor transcripts. Comparison with published pre-vaccine fatal COVID-19 transcriptomic and genomic signatures uncovered a unique IRF3 low/IRF7 high immune signature in post-vaccine fatal COVID-19 outbreaks. A multi-layered strategy, including environmental sampling, immunomonitoring and early antiviral therapy, should be considered to prevent post-vaccination COVID-19 mortality in nursing homes., (© 2023. The Author(s).)

Published
2023
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