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My Health Minnesota → Go Local is part of the MedlinePlus® Go Local initiative sponsored by the National Library of Medicine (NLM). NLM recently announced that MedlinePlus Go Local will end, beginning in spring 2010. Despite the imminent end to MedlinePlus Go Local, My Health Minnesota → Go Local and other Go Local projects still provide rich examples of outreach experiences that are relevant to other projects and other libraries. [ABSTRACT FROM AUTHOR]

Diabetes has been identified as a priority health issue for women and is a serious chronic condition that occurs more frequently in women than in men. Diabetes brings with it unique concerns for women at all stages in the life span. The woman with diabetes must take an active role in her own diabetes management and needs access to reliable, accurate, and useful diabetes-related information. The World Wide Web provides ready access to diabetes-related resources, and when properly used, can serve as a valuable tool in diabetes self-care. This article provides a listing of selected, annotated Web resources of particular interest to women with diabetes. [ABSTRACT FROM AUTHOR]

Gestational diabetes is a common medical problem in pregnancy. Statistics indicate that between 3 percent and 12 percent of pregnant women will develop gestational diabetes each year. The World-Wide Web provides pregnant women and their concerned families and friends with convenient access to diabetes-related information and resources. Included in this article is a select, annotated list of Web-based resources concerning gestational diabetes. [ABSTRACT FROM AUTHOR]

Rats injected intravenously with immune complexes (IC) prepared in 5x antigen excess were reported previously to develop a distinctive striped pattern of serosal hyperemia of the small intestine accompanied by mucosal edema and hemorrhage. This study tested the effect of repeated injections of IC given at 3-day intervals. After the last of four, six, or nine injections, rats continued to show the same gross and histologic lesions observed in rats injected once with IC. After serial injections, however, the distal small intestine was more severely involved than the proximal intestine. In addition, villous shortening, stromal hemosiderin deposits, and gut-associated lymphoid tissue and mesenteric lymph node sinus hemorrhage and hemosiderin deposits were seen in rats given nine injections. There was a remarkable absence of stromal infiltration of the villi by inflammatory cells. Experiments conducted with 125I-labeled IC plus sufficient "cold" IC to induce intestinal lesions showed that IC were deposited at extravascular sites in the gut. The failure of such IC to provoke cellular infiltration in the gut is unexplained.

IgGa, in contrast to IgE, antibodies mediated the antigen-induced release of histamine from rat peritoneal mast cells without a requirement for a latent period and without the capacity to bind firmly to the target cell. Nonetheless, IgGa anti-DNP antibody interfered with the capacity of rat anti-N. brasiliensis antiserum rich in IgE antibodies to prepare the target cells for histamine release by worm antigen. Further, interaction of IgE antibody-prepared cells with IgGa anti-DNP antibody and DNP-BSA at 0 degrees C so as to achieve sterile activation, or at 30 degrees C to permit histamine release, inactivated such cells as determined by the subsequent failure to release histamine upon challenge with worm antigen. Thus, although IgE and IgGa antibodies are immunochemically distinct homologous immunoglobulins and exhibit different functional characteristics, their interaction at the target cell involves a common receptor and at least one common point in the pathway to the release of pharmacologic agents from the cell.