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Your search keyword '"Blijlevens, Maxime"' showing total 12 results
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12 results on '"Blijlevens, Maxime"'

1. Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma

Author

Sciarrillo, Rocco, Wojtuszkiewicz, Anna, El Hassouni, Btissame, Funel, Niccola, Gandellini, Paolo, Lagerweij, Tonny, Buonamici, Silvia, Blijlevens, Maxime, Zeeuw van der Laan, Eveline A., Zaffaroni, Nadia, Deraco, Marcello, Kusamura, Shigeki, Würdinger, Tom, Peters, Godefridus J., Molthoff, Carla F.M., Jansen, Gerrit, Kaspers, Gertjan J.L., Cloos, Jacqueline, and Giovannetti, Elisa

Published
2019
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3. Data from Functional Genomic Screen in Mesothelioma Reveals that Loss of Function of BRCA1-Associated Protein 1 Induces Chemoresistance to Ribonucleotide Reductase Inhibition

Author

Okonska, Agata, primary, Bühler, Saskja, primary, Rao, Vasundhara, primary, Ronner, Manuel, primary, Blijlevens, Maxime, primary, van der Meulen-Muileman, Ida H., primary, de Menezes, Renee X., primary, Wipplinger, Martin, primary, Oehl, Kathrin, primary, Smit, Egbert F., primary, Weder, Walter, primary, Stahel, Rolf A., primary, Penengo, Lorenza, primary, van Beusechem, Victor W., primary, and Felley-Bosco, Emanuela, primary

Published
2023
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4. Supplementary Data from Functional Genomic Screen in Mesothelioma Reveals that Loss of Function of BRCA1-Associated Protein 1 Induces Chemoresistance to Ribonucleotide Reductase Inhibition

Author

Okonska, Agata, primary, Bühler, Saskja, primary, Rao, Vasundhara, primary, Ronner, Manuel, primary, Blijlevens, Maxime, primary, van der Meulen-Muileman, Ida H., primary, de Menezes, Renee X., primary, Wipplinger, Martin, primary, Oehl, Kathrin, primary, Smit, Egbert F., primary, Weder, Walter, primary, Stahel, Rolf A., primary, Penengo, Lorenza, primary, van Beusechem, Victor W., primary, and Felley-Bosco, Emanuela, primary

Published
2023
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7. Functional Genomic Screen in Mesothelioma Reveals that Loss of Function of BRCA1-Associated Protein 1 Induces Chemoresistance to Ribonucleotide Reductase Inhibition

Author

Okonska, Agata, primary, Bühler, Saskja, additional, Rao, Vasundhara, additional, Ronner, Manuel, additional, Blijlevens, Maxime, additional, van der Meulen-Muileman, Ida H., additional, de Menezes, Renee X., additional, Wipplinger, Martin, additional, Oehl, Kathrin, additional, Smit, Egbert F., additional, Weder, Walter, additional, Stahel, Rolf A., additional, Penengo, Lorenza, additional, van Beusechem, Victor W., additional, and Felley-Bosco, Emanuela, additional

Published
2020
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8. Genome-wide silencing screen in mesothelioma cells reveals that loss of function of BAP1 induces chemoresistance to ribonucleotide reductase inhibition: implication for therapy

Author

Okonska, Agata, primary, Bühler, Saskja, additional, Rao, Vasundhara, additional, Ronner, Manuel, additional, Blijlevens, Maxime, additional, Meulen-Muileman, Ida Van der, additional, Menezes, Renee de, additional, Smit, Egbert, additional, Weder, Walter, additional, Stahel, Rolf, additional, Penengo, Lorenza, additional, Beusechem, Victor van, additional, and Felley-Bosco, Emanuela, additional

Published
2018
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10. A genome-wide si RNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment.

Author

Siebring ‐ van Olst, Ellen, Blijlevens, Maxime, Menezes, Renee X., Meulen ‐ Muileman, Ida H., Smit, Egbert F., and Beusechem, Victor W.

Abstract

Reinstating wild-type tumor suppressor p53 activity could be a valuable option for the treatment of cancer. To contribute to development of new treatment options for non-small cell lung cancer ( NSCLC), we performed genome-wide si RNA screens for determinants of p53 activity in NSCLC cells. We identified many genes not previously known to be involved in regulating p53 activity. Silencing p53 pathway inhibitor genes was associated with loss of cell viability. The largest functional gene cluster influencing p53 activity was mRNA splicing. Prominent p53 activation was observed upon silencing of specific spliceosome components, rather than by general inhibition of the spliceosome. Ten genes were validated as inhibitors of p53 activity in multiple NSCLC cell lines: genes encoding the Ras pathway activator SOS1, the zinc finger protein TSHZ3, the mitochondrial membrane protein COX16, and the spliceosome components SNRPD3, SF3A3, SF3B1, SF3B6, XAB2, CWC22, and HNRNPL. Silencing these genes generally increased p53 levels, with distinct effects on CDKN1A expression, induction of cell cycle arrest and cell death. Silencing spliceosome components was associated with alternative splicing of MDM4 mRNA, which could contribute to activation of p53. In addition, silencing splice factors was particularly effective in killing NSCLC cells, albeit in a p53-independent manner. Interestingly, silencing SNRPD3 and SF3A3 exerted much stronger cytotoxicity to NSCLC cells than to lung fibroblasts, suggesting that these genes could represent useful therapeutic targets. [ABSTRACT FROM AUTHOR]

Published
2017
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11. Sox4 Expression Confers Bladder Cancer Stem Cell Properties and Predicts for Poor Patient Outcome

Author

Shen, He, primary, Blijlevens, Maxime, additional, Yang, Nuo, additional, Frangou, Costakis, additional, Wilson, Kayla E., additional, Xu, Bo, additional, Zhang, Yinglong, additional, Zhang, Lirui, additional, Morrison, Carl D., additional, Shepherd, Lori, additional, Hu, Qiang, additional, Zhu, Qianqian, additional, Wang, Jianmin, additional, Liu, Song, additional, and Zhang, Jianmin, additional

Published
2015
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