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132 results on '"Blijham, Geert H."'

10. Euthanasia

Author

Blijham, Geert H.

Published
2003

11. Familial medullary thyroid carcinoma: not a distinct entity? Genotype-phenotype correlation in a large family

Author

Moers, Andre M.J., Landsvater, Rudy M., Schaap, Cees, Veen, Joke M. Jansen-Schillhorn van, Valk, Irene A.J. de, Blijham, Geert H., Hoppener, Jo W.M., Vroom, Thea M., Amstel, Kristian Ploos van, and Lips, Cornelis J.M.

Subjects
Thyroid cancer -- Genetic aspects, Familial diseases -- Research, Health, Health care industry
Abstract

BACKGROUND: Multiple endocrine neoplasia type 2A (MEN 2A) is a hereditary syndrome characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, and hyperparathyroidism. Familial MTC (FMTC) is characterized by MTC only. Both MEN 2A and FMTC are caused by germline mutations of the RET proto-oncogene. PURPOSE: To assess genotype/phenotype correlations, large families have to be examined periodically over a long period using an extensive screening program. PATIENTS AND METHODS: Since 1973, we screened a large family with hereditary C cell carcinoma for MTC, pheochromocytoma, and parathyroid disease by clinical tests and imaging methods. A germline codon Cys618 to Ser mutation in the RET proto-oncogene was recently identified in this family. The disease phenotype associated with this mutation was compared with that of Cys634 mutations in some other large MEN 2A families. RESULTS: The distinct course of disease in the family described here is similar to that in other FMTC families and MEN 2A families with a Cys618 mutation of the RET gene, but clearly different from that in families with a Cys634 mutation. The frequency of pheochromocytomas and parathyroid disease is clearly lower, whereas cure rates and life expectancy are higher. However, in families with a Cys618 mutation, pheochromocytoma and parathyroid disease do occur. CONCLUSION: In FMTC families with cysteine codon mutations of the RET proto-oncogene, screening for other endocrinopathies is mandatory, since these may not be MTC-only families. Therefore, we suggest that MEN 2A families should not be subclassified into MEN 2A and FMTC, but rather according to their specific mutation in the RET protein fie, for this family MEN 2A RET C618s). 1996 by Excerpta Medica, Inc. Am J Med. 1996;101:635-641.

Published
1996

14. Recurrent adult nephroblastoma: long-term remission after surgery plus adjuvant high-dose chemotherapy, radiation therapy, and allogeneic bone marrow transplantation

Author

Hupperets, Pierre S., Havenith, Miek G., and Blijham, Geert H.

Subjects
Nephroblastoma -- Diagnosis, Chemotherapy, Combination -- Usage, Radiotherapy -- Usage, Bone marrow -- Transplantation, Cancer -- Relapse, Health
Abstract

The authors report a case of Stage IV, unfavorable histologic type adult nephroblastoma. The patient was treated with multimodal therapy: combination chemotherapy consisting of cyclophosphamide, doxorubicin, cisplatin, and etoposide succeeded by nephrectomy and radiation therapy. After a disease-free period of 27 months, a pararectal relapse was treated by surgery, high-dose chemotherapy, and allogeneic bone marrow transplantation (BMT). The patient is alive and disease-free 3.5 years after BMT. Cancer 1992; 69:2990-2992.

Published
1992

15. Abstracts of papers Toxicological meeting

Author

Breukink, H. J., Baars, A. J., Vroomen, L. H. M., Jager, L. P., Korstanje, C., Witkamp, R. J., van Leeuwen, F. X. R., Boogaard, P. J., Zoeteweij, J. P., Mulder, G. J., Nagelkerke, J. F., Bos, R. P., Kromhout, H., Ikink, H., Theuws, J. L. G., Dentener, M. A., Maessen, J. G., Buurman, W. A., de Vries, H., Bojarski, J., van Henegouwen, G. M. J. Beijersbergen, de Wolff, F. A., van Welsum, R. A., Marani, E., van Keep, J. P., van der Voet, G. B., den Besten, P. J., Livingstone, D. R., Dogterom, P., Evelo, C. T. A., Fijneman, P. H. S., Pötgens, A. J. G., Furnée, Carina, Verhagen, Hans, Schutte, Bert, Reynders, Michèle M. J., Blijham, Geert H., ten Hoor, Foppe, Kieinjans, Jos C. S., Haenen, G. R. M. M., Bast, A., Hageman, Geja, Kjkken, Rene, Kleinjans, Jos, Welle, Irene, Hajee, C. A. J., Rietveld, E. C., Seutter-Berlage, F., Hoogenboom, L. A. P., van Vliet, T., Kuiper, H. A., Canssen, Y., Hageman, G., van Agen, B., Schreurs, J., Jongeneelen, F. J., van Schooten, F. J., Kriek, E., van Leeuwen, F., Kelder, P. P., Dubbeling, M., de Mol, N. J., Janssen, L. H. M., Koymans, Luc, van Lenthe, Joop H., van de Straat, Ronald, den Kelder, Gabriëlle M. Donn-Op, Vermeulen, Nico P. E., Luyckx, Niels B. Lucas, Mennes, Wim C., van Pelt, Frank N. A. M., Noordhoek, Jan, Blaauboer, Bas J., Lusthof, K. J., Richter, W., Mannes, Wim C., van Holsteijn, Ineke W. M., Spierenburg, Th. J., van der Molen, E. J., de Graaf, G. J., Jager, L. P., Spierenburo, Th. J., Jager, L. P., Brus, D. H. J., Tielen, M. J. M., Arts, B. J., Stijntjes, G. J., Vermeulen, N. P. E., ten Hoor, F., ten Kate, J., Moerkerk, P., Bosman, F., Kleinjans, J., van Benthem, J., Wilmer, J. W. G. M., Leeman, U. R., Winterwerp, H. H. K., den Engelse, L., Scherer, E., van Bree, L., Rietjens, I. M. C. M., Verhoef, M. A., de Boer, R., Muller, J. J. A., Dormans, J. A. M. A., Rombout, P. J. A., van de Poll, M. L. M., van der Hulst, O. A. M., Tates, A. D., Meerman, J. H. N., van de Wiel, J. A. G., Duyf, C. M. P., Bos, P. P., Verweij, P. E., Sips, A., van Erp, Yvette H. H., Heirbaut, Petra R. C. M., Koopmans, Marion J. E., Weterings, Peter J. J. M., van Ginkel, M. F., van der Voet, E. V., van Loveren, H., Blommaert, F. A., Krajnc, E. I., Vos, J. G., van Ommen, Ben, Bogaards, Jan, van Bladeren, Peter J., van der Heijden, Ruud M., Hassing, Ine G. A. M., van Welie, R. T. H., van Duyn, P., Beckers, Rico H. G., Kleinjans, Jos C. S., and Maas, Lou M.

Published
1989
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17. Textbook of Medical Oncology

Author

Blijham, Geert H.

Subjects
Textbook of Medical Oncology (Book) -- Book reviews, Books -- Book reviews
Published
1997

19. The relationship between aromatase in primary breast tumors and response to treatment with aromatase inhibitors in advanced disease

Author

de Jong, Paul Chr, primary, Blankenstein, Marinus A, additional, Nortier, Johannes W.R, additional, Slee, Peter H.Th.J, additional, van de Ven, Joost, additional, van Gorp, Joost M.H.H, additional, Elbers, Johannes R.J, additional, Schipper, Margriet E.I, additional, Blijham, Geert H, additional, Thijssen, Jos H.H, additional, Lu, Qing, additional, Jelovac, Danijela, additional, and Brodie, Angela M, additional

Published
2003
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25. Breast Cancer

Author

Blijham, Geert H.

Subjects
Breast Cancer (Book), Books -- Book reviews
Published
1999

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