6 results on '"Blechschmidt L"'
Search Results
2. CropPol: A dynamic, open and global database on crop pollination
- Author
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Allen-Perkins, A, Magrach, A, Dainese, M, Garibaldi, LA, Kleijn, D, Rader, R, Reilly, JR, Winfree, R, Lundin, O, McGrady, CM, Brittain, C, Biddinger, DJ, Artz, DR, Elle, E, Hoffman, G, Ellis, JD, Daniels, J, Gibbs, J, Campbell, JW, Brokaw, J, Wilson, JK, Mason, K, Ward, KL, Gundersen, KB, Bobiwash, K, Gut, L, Rowe, LM, Boyle, NK, Williams, NM, Joshi, NK, Rothwell, N, Gillespie, RL, Isaacs, R, Fleischer, SJ, Peterson, SS, Rao, S, Pitts-Singer, TL, Fijen, T, Boreux, V, Rundlof, M, Viana, BF, Klein, A-M, Smith, HG, Bommarco, R, Carvalheiro, LG, Ricketts, TH, Ghazoul, J, Krishnan, S, Benjamin, FE, Loureiro, J, Castro, S, Raine, NE, de Groot, GA, Horgan, FG, Hipolito, J, Smagghe, G, Meeus, I, Eeraerts, M, Potts, SG, Kremen, C, Garcia, D, Minarro, M, Crowder, DW, Pisanty, G, Mandelik, Y, Vereecken, NJ, Leclercq, N, Weekers, T, Lindstrom, SAM, Stanley, DA, Zaragoza-Trello, C, Nicholson, CC, Scheper, J, Rad, C, Marks, EAN, Mota, L, Danforth, B, Park, M, Bezerra, ADM, Freitas, BM, Mallinger, RE, Oliveira da Silva, F, Willcox, B, Ramos, DL, da Silva e Silva, FD, Lazaro, A, Alomar, D, Gonzalez-Estevez, MA, Taki, H, Cariveau, DP, Garratt, MPD, Nabaes Jodar, DN, Stewart, RIA, Ariza, D, Pisman, M, Lichtenberg, EM, Schueepp, C, Herzog, F, Entling, MH, Dupont, YL, Michener, CD, Daily, GC, Ehrlich, PR, Burns, KLW, Vila, M, Robson, A, Howlett, B, Blechschmidt, L, Jauker, F, Schwarzbach, F, Nesper, M, Diekoetter, T, Wolters, V, Castro, H, Gaspar, H, Nault, BA, Badenhausser, I, Petersen, JD, Tscharntke, T, Bretagnolle, V, Willis Chan, DS, Chacoff, N, Andersson, GKS, Jha, S, Colville, JF, Veldtman, R, Coutinho, J, Bianchi, FJJA, Sutter, L, Albrecht, M, Jeanneret, P, Zou, Y, Averill, AL, Saez, A, Sciligo, AR, Vergara, CH, Bloom, EH, Oeller, E, Badano, EI, Loeb, GM, Grab, H, Ekroos, J, Gagic, V, Cunningham, SA, Astrom, J, Cavigliasso, P, Trillo, A, Classen, A, Mauchline, AL, Montero-Castano, A, Wilby, A, Woodcock, BA, Sidhu, CS, Steffan-Dewenter, I, Vogiatzakis, IN, Herrera, JM, Otieno, M, Gikungu, MW, Cusser, SJ, Nauss, T, Nilsson, L, Knapp, J, Ortega-Marcos, JJ, Gonzalez, JA, Osborne, JL, Blanche, R, Shaw, RF, Hevia, V, Stout, J, Arthur, AD, Blochtein, B, Szentgyorgyi, H, Li, J, Mayfield, MM, Woyciechowski, M, Nunes-Silva, P, Halinski de Oliveira, R, Henry, S, Simmons, BI, Dalsgaard, B, Hansen, K, Sritongchuay, T, O'Reilly, AD, Chamorro Garcia, FJ, Nates Parra, G, Magalhaes Pigozo, C, Bartomeus, I, Allen-Perkins, A, Magrach, A, Dainese, M, Garibaldi, LA, Kleijn, D, Rader, R, Reilly, JR, Winfree, R, Lundin, O, McGrady, CM, Brittain, C, Biddinger, DJ, Artz, DR, Elle, E, Hoffman, G, Ellis, JD, Daniels, J, Gibbs, J, Campbell, JW, Brokaw, J, Wilson, JK, Mason, K, Ward, KL, Gundersen, KB, Bobiwash, K, Gut, L, Rowe, LM, Boyle, NK, Williams, NM, Joshi, NK, Rothwell, N, Gillespie, RL, Isaacs, R, Fleischer, SJ, Peterson, SS, Rao, S, Pitts-Singer, TL, Fijen, T, Boreux, V, Rundlof, M, Viana, BF, Klein, A-M, Smith, HG, Bommarco, R, Carvalheiro, LG, Ricketts, TH, Ghazoul, J, Krishnan, S, Benjamin, FE, Loureiro, J, Castro, S, Raine, NE, de Groot, GA, Horgan, FG, Hipolito, J, Smagghe, G, Meeus, I, Eeraerts, M, Potts, SG, Kremen, C, Garcia, D, Minarro, M, Crowder, DW, Pisanty, G, Mandelik, Y, Vereecken, NJ, Leclercq, N, Weekers, T, Lindstrom, SAM, Stanley, DA, Zaragoza-Trello, C, Nicholson, CC, Scheper, J, Rad, C, Marks, EAN, Mota, L, Danforth, B, Park, M, Bezerra, ADM, Freitas, BM, Mallinger, RE, Oliveira da Silva, F, Willcox, B, Ramos, DL, da Silva e Silva, FD, Lazaro, A, Alomar, D, Gonzalez-Estevez, MA, Taki, H, Cariveau, DP, Garratt, MPD, Nabaes Jodar, DN, Stewart, RIA, Ariza, D, Pisman, M, Lichtenberg, EM, Schueepp, C, Herzog, F, Entling, MH, Dupont, YL, Michener, CD, Daily, GC, Ehrlich, PR, Burns, KLW, Vila, M, Robson, A, Howlett, B, Blechschmidt, L, Jauker, F, Schwarzbach, F, Nesper, M, Diekoetter, T, Wolters, V, Castro, H, Gaspar, H, Nault, BA, Badenhausser, I, Petersen, JD, Tscharntke, T, Bretagnolle, V, Willis Chan, DS, Chacoff, N, Andersson, GKS, Jha, S, Colville, JF, Veldtman, R, Coutinho, J, Bianchi, FJJA, Sutter, L, Albrecht, M, Jeanneret, P, Zou, Y, Averill, AL, Saez, A, Sciligo, AR, Vergara, CH, Bloom, EH, Oeller, E, Badano, EI, Loeb, GM, Grab, H, Ekroos, J, Gagic, V, Cunningham, SA, Astrom, J, Cavigliasso, P, Trillo, A, Classen, A, Mauchline, AL, Montero-Castano, A, Wilby, A, Woodcock, BA, Sidhu, CS, Steffan-Dewenter, I, Vogiatzakis, IN, Herrera, JM, Otieno, M, Gikungu, MW, Cusser, SJ, Nauss, T, Nilsson, L, Knapp, J, Ortega-Marcos, JJ, Gonzalez, JA, Osborne, JL, Blanche, R, Shaw, RF, Hevia, V, Stout, J, Arthur, AD, Blochtein, B, Szentgyorgyi, H, Li, J, Mayfield, MM, Woyciechowski, M, Nunes-Silva, P, Halinski de Oliveira, R, Henry, S, Simmons, BI, Dalsgaard, B, Hansen, K, Sritongchuay, T, O'Reilly, AD, Chamorro Garcia, FJ, Nates Parra, G, Magalhaes Pigozo, C, and Bartomeus, I
- Abstract
Seventy five percent of the world's food crops benefit from insect pollination. Hence, there has been increased interest in how global change drivers impact this critical ecosystem service. Because standardized data on crop pollination are rarely available, we are limited in our capacity to understand the variation in pollination benefits to crop yield, as well as to anticipate changes in this service, develop predictions, and inform management actions. Here, we present CropPol, a dynamic, open, and global database on crop pollination. It contains measurements recorded from 202 crop studies, covering 3,394 field observations, 2,552 yield measurements (i.e., berry mass, number of fruits, and fruit density [kg/ha], among others), and 47,752 insect records from 48 commercial crops distributed around the globe. CropPol comprises 32 of the 87 leading global crops and commodities that are pollinator dependent. Malus domestica is the most represented crop (32 studies), followed by Brassica napus (22 studies), Vaccinium corymbosum (13 studies), and Citrullus lanatus (12 studies). The most abundant pollinator guilds recorded are honey bees (34.22% counts), bumblebees (19.19%), flies other than Syrphidae and Bombyliidae (13.18%), other wild bees (13.13%), beetles (10.97%), Syrphidae (4.87%), and Bombyliidae (0.05%). Locations comprise 34 countries distributed among Europe (76 studies), North America (60), Latin America and the Caribbean (29), Asia (20), Oceania (10), and Africa (7). Sampling spans three decades and is concentrated on 2001-2005 (21 studies), 2006-2010 (40), 2011-2015 (88), and 2016-2020 (50). This is the most comprehensive open global data set on measurements of crop flower visitors, crop pollinators and pollination to date, and we encourage researchers to add more datasets to this database in the future. This data set is released for non-commercial use only. Credits should be given to this paper (i.e., proper citation), and the products generated with this da
- Published
- 2022
3. Magnetic Anisotropy and Relaxation of Pseudotetrahedral [N 2 O 2 ] Bis-Chelate Cobalt(II) Single-Ion Magnets Controlled by Dihedral Twist Through Solvomorphism.
- Author
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Pohle MH, Böhme M, Lohmiller T, Ziegenbalg S, Blechschmidt L, Görls H, Schnegg A, and Plass W
- Abstract
The methanol solvomorph 1 ⋅ 2MeOH of the cobalt(II) complex [Co(L
Sal,2-Ph )2 ] (1) with the sterically demanding Schiff-base ligand 2-(([1,1'-biphenyl]-2-ylimino)methyl)phenol (HLSal,2-Ph ) shows the thus far largest dihedral twist distortion between the two chelate planes compared to an ideal pseudotetrahedral arrangement. The cobalt(II) ion in 1 ⋅ 2MeOH exhibits an easy-axis anisotropy leading to a spin-reversal barrier of 55.3 cm-1 , which corresponds to an increase of about 17 % induced by the larger dihedral twist compared to the solvent-free complex 1. The magnetic relaxation for 1 ⋅ 2MeOH is significantly slower compared to 1. An in-depth frequency-domain Fourier-transform (FD-FT) THz-EPR study not only allowed the direct measurement of the magnetic transition between the two lowest Kramers doublets for the cobalt(II) complexes, but also revealed the presence of spin-phonon coupling. Interestingly, a similar dihedral twist correlation is also observed for a second pair of cobalt(II)-based solvomorphs, which could be benchmarked by FD-FT THz-EPR., (© 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)- Published
- 2023
- Full Text
- View/download PDF
4. CropPol: A dynamic, open and global database on crop pollination.
- Author
-
Allen-Perkins A, Magrach A, Dainese M, Garibaldi LA, Kleijn D, Rader R, Reilly JR, Winfree R, Lundin O, McGrady CM, Brittain C, Biddinger DJ, Artz DR, Elle E, Hoffman G, Ellis JD, Daniels J, Gibbs J, Campbell JW, Brokaw J, Wilson JK, Mason K, Ward KL, Gundersen KB, Bobiwash K, Gut L, Rowe LM, Boyle NK, Williams NM, Joshi NK, Rothwell N, Gillespie RL, Isaacs R, Fleischer SJ, Peterson SS, Rao S, Pitts-Singer TL, Fijen T, Boreux V, Rundlöf M, Viana BF, Klein AM, Smith HG, Bommarco R, Carvalheiro LG, Ricketts TH, Ghazoul J, Krishnan S, Benjamin FE, Loureiro J, Castro S, Raine NE, de Groot GA, Horgan FG, Hipólito J, Smagghe G, Meeus I, Eeraerts M, Potts SG, Kremen C, García D, Miñarro M, Crowder DW, Pisanty G, Mandelik Y, Vereecken NJ, Leclercq N, Weekers T, Lindstrom SAM, Stanley DA, Zaragoza-Trello C, Nicholson CC, Scheper J, Rad C, Marks EAN, Mota L, Danforth B, Park M, Bezerra ADM, Freitas BM, Mallinger RE, Oliveira da Silva F, Willcox B, Ramos DL, D da Silva E Silva F, Lázaro A, Alomar D, González-Estévez MA, Taki H, Cariveau DP, Garratt MPD, Nabaes Jodar DN, Stewart RIA, Ariza D, Pisman M, Lichtenberg EM, Schüepp C, Herzog F, Entling MH, Dupont YL, Michener CD, Daily GC, Ehrlich PR, Burns KLW, Vilà M, Robson A, Howlett B, Blechschmidt L, Jauker F, Schwarzbach F, Nesper M, Diekötter T, Wolters V, Castro H, Gaspar H, Nault BA, Badenhausser I, Petersen JD, Tscharntke T, Bretagnolle V, Willis Chan DS, Chacoff N, Andersson GKS, Jha S, Colville JF, Veldtman R, Coutinho J, Bianchi FJJA, Sutter L, Albrecht M, Jeanneret P, Zou Y, Averill AL, Saez A, Sciligo AR, Vergara CH, Bloom EH, Oeller E, Badano EI, Loeb GM, Grab H, Ekroos J, Gagic V, Cunningham SA, Åström J, Cavigliasso P, Trillo A, Classen A, Mauchline AL, Montero-Castaño A, Wilby A, Woodcock BA, Sidhu CS, Steffan-Dewenter I, Vogiatzakis IN, Herrera JM, Otieno M, Gikungu MW, Cusser SJ, Nauss T, Nilsson L, Knapp J, Ortega-Marcos JJ, González JA, Osborne JL, Blanche R, Shaw RF, Hevia V, Stout J, Arthur AD, Blochtein B, Szentgyorgyi H, Li J, Mayfield MM, Woyciechowski M, Nunes-Silva P, Halinski de Oliveira R, Henry S, Simmons BI, Dalsgaard B, Hansen K, Sritongchuay T, O'Reilly AD, Chamorro García FJ, Nates Parra G, Magalhães Pigozo C, and Bartomeus I
- Subjects
- Animals, Bees, Crops, Agricultural, Flowers, Insecta, Ecosystem, Pollination
- Abstract
Seventy five percent of the world's food crops benefit from insect pollination. Hence, there has been increased interest in how global change drivers impact this critical ecosystem service. Because standardized data on crop pollination are rarely available, we are limited in our capacity to understand the variation in pollination benefits to crop yield, as well as to anticipate changes in this service, develop predictions, and inform management actions. Here, we present CropPol, a dynamic, open, and global database on crop pollination. It contains measurements recorded from 202 crop studies, covering 3,394 field observations, 2,552 yield measurements (i.e., berry mass, number of fruits, and fruit density [kg/ha], among others), and 47,752 insect records from 48 commercial crops distributed around the globe. CropPol comprises 32 of the 87 leading global crops and commodities that are pollinator dependent. Malus domestica is the most represented crop (32 studies), followed by Brassica napus (22 studies), Vaccinium corymbosum (13 studies), and Citrullus lanatus (12 studies). The most abundant pollinator guilds recorded are honey bees (34.22% counts), bumblebees (19.19%), flies other than Syrphidae and Bombyliidae (13.18%), other wild bees (13.13%), beetles (10.97%), Syrphidae (4.87%), and Bombyliidae (0.05%). Locations comprise 34 countries distributed among Europe (76 studies), North America (60), Latin America and the Caribbean (29), Asia (20), Oceania (10), and Africa (7). Sampling spans three decades and is concentrated on 2001-2005 (21 studies), 2006-2010 (40), 2011-2015 (88), and 2016-2020 (50). This is the most comprehensive open global data set on measurements of crop flower visitors, crop pollinators and pollination to date, and we encourage researchers to add more datasets to this database in the future. This data set is released for non-commercial use only. Credits should be given to this paper (i.e., proper citation), and the products generated with this database should be shared under the same license terms (CC BY-NC-SA)., (© 2021 The Ecological Society of America.)
- Published
- 2022
- Full Text
- View/download PDF
5. The STAT5b Linker Domain Mediates the Selectivity of Catechol Bisphosphates for STAT5b over STAT5a.
- Author
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Gräb J, Berg A, Blechschmidt L, Klüver B, Rubner S, Fu DY, Meiler J, Gräber M, and Berg T
- Subjects
- Binding Sites, Humans, Protein Binding, Catechols chemistry, Catechols metabolism, Protein Interaction Domains and Motifs, STAT5 Transcription Factor chemistry, STAT5 Transcription Factor metabolism, Tumor Suppressor Proteins chemistry, Tumor Suppressor Proteins metabolism, src Homology Domains
- Abstract
STAT family proteins are important mediators of cell signaling and represent therapeutic targets for the treatment of human diseases. Most STAT inhibitors target the protein-protein interaction domain, the SH2 domain, but specificity for a single STAT protein is often limited. Recently, we developed catechol bisphosphates as the first inhibitors of STAT5b demonstrated to exhibit a high degree of selectivity over the close homologue STAT5a. Here, we show that the amino acid in position 566 of the linker domain, not the SH2 domain, is the main determinant of specificity. Arg566 in wild-type STAT5b favors tight binding of catechol bisphosphates, while Trp566 in wild-type STAT5a does not. Amino acid 566 also determines the affinity for a tyrosine-phosphorylated peptide derived from the EPO receptor for STAT5a and STAT5b, demonstrating the functional relevance of the STAT5 linker domain for the adjacent SH2 domain. These results provide the first demonstration that a residue in the linker domain can determine the affinity of nonpeptidic small-molecule inhibitors for the SH2 domain of STAT proteins. We propose targeting the interface between the SH2 domain and linker domain as a novel design approach for the development of potent and selective STAT inhibitors. In addition, our data suggest that the linker domain could contribute to the enigmatically divergent biological functions of the two STAT5 proteins.
- Published
- 2019
- Full Text
- View/download PDF
6. Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b.
- Author
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Elumalai N, Berg A, Rubner S, Blechschmidt L, Song C, Natarajan K, Matysik J, and Berg T
- Subjects
- Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Binding Sites, Catechols chemical synthesis, Catechols chemistry, Cell Line, Tumor, Humans, Molecular Docking Simulation, Phosphorylation, Protein Binding, Protein Processing, Post-Translational, Quantitative Structure-Activity Relationship, STAT5 Transcription Factor chemistry, STAT5 Transcription Factor metabolism, src Homology Domains, Antineoplastic Agents pharmacology, Catechols pharmacology, STAT5 Transcription Factor antagonists & inhibitors
- Abstract
The transcription factor STAT5b is a target for tumour therapy. We recently reported catechol bisphosphate and derivatives such as Stafib-1 as the first selective inhibitors of the STAT5b SH2 domain. Here, we demonstrate STAT5b binding of catechol bisphosphate by solid-state nuclear magnetic resonance, and report on rational optimization of Stafib-1 (K
i = 44 nM) to Stafib-2 (Ki = 9 nM). The binding site of Stafib-2 was validated using combined isothermal titration calorimetry (ITC) and protein point mutant analysis, representing the first time that functional comparison of wild-type versus mutant protein by ITC has been used to characterize the binding site of a small-molecule ligand of a STAT protein with amino acid resolution. The prodrug Pomstafib-2 selectively inhibits tyrosine phosphorylation of STAT5b in human leukaemia cells and induces apoptosis in a STAT5-dependent manner. We propose Pomstafib-2, which currently represents the most active, selective inhibitor of STAT5b activation available, as a chemical tool for addressing the fundamental question of which roles the different STAT5 proteins play in various cell processes.- Published
- 2017
- Full Text
- View/download PDF
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