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2. The Science Performance of JWST as Characterized in Commissioning

Author

Rigby, J, Perrin, M, McElwain, M, Kimble, R, Friedman, S, Lallo, M, Doyon, R, Feinberg, L, Ferruit, P, Glasse, A, Rieke, M, Rieke, G, Wright, G, Willott, C, Colon, K, Milam, S, Neff, S, Stark, C, Valenti, J, Abell, J, Abney, F, Abul-Huda, Y, Scott Acton, D, Adams, E, Adler, D, Aguilar, J, Ahmed, N, Albert, L, Alberts, S, Aldridge, D, Allen, M, Altenburg, M, Álvarez-Márquez, J, Alves De Oliveira, C, Andersen, G, Anderson, H, Anderson, S, Argyriou, I, Armstrong, A, Arribas, S, Artigau, E, Arvai, A, Atkinson, C, Bacon, G, Bair, T, Banks, K, Barrientes, J, Barringer, B, Bartosik, P, Bast, W, Baudoz, P, Beatty, T, Bechtold, K, Beck, T, Bergeron, E, Bergkoetter, M, Bhatawdekar, R, Birkmann, S, Blazek, R, Blome, C, Boccaletti, A, Böker, T, Boia, J, Bonaventura, N, Bond, N, Bosley, K, Boucarut, R, Bourque, M, Bouwman, J, Bower, G, Bowers, C, Boyer, M, Bradley, L, Brady, G, Braun, H, Breda, D, Bresnahan, P, Bright, S, Britt, C, Bromenschenkel, A, Brooks, B, Brooks, K, Brown, B, Brown, M, Brown, P, Bunker, A, Burger, M, Bushouse, H, Cale, S, Cameron, A, Cameron, P, Canipe, A, Caplinger, J, Caputo, F, Cara, M, Carey, L, Carniani, S, Carrasquilla, M, Carruthers, M, Case, M, Rigby, J [0000-0002-7627-6551], McElwain, M [0000-0003-0241-8956], Ferruit, P [0000-0001-8895-0606], Rieke, M [0000-0002-7893-6170], Willott, C [0000-0002-4201-7367], and Apollo - University of Cambridge Repository

Subjects
Infrared astronomy, Observatories, Astronomical instrumentation
Abstract

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.

Published
2023
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3. Selection on Phalanx Development in the Evolution of the Bird Wing

Author

Harris, K, de Bakker, MAG, van der Vos, W, de Jager, K, Chung, WY, Fowler, DA, Dondorp, E, Spiekman, SNF, Chew, KY, Xie, B, Jimenez, R, Bickelmann, C, Kuratani, S, Blazek, R, Kondrashov, P, Renfree, MB, Richardson, MK, Harris, K, de Bakker, MAG, van der Vos, W, de Jager, K, Chung, WY, Fowler, DA, Dondorp, E, Spiekman, SNF, Chew, KY, Xie, B, Jimenez, R, Bickelmann, C, Kuratani, S, Blazek, R, Kondrashov, P, Renfree, MB, and Richardson, MK

Abstract

The frameshift hypothesis is a widely accepted model of bird wing evolution. This hypothesis postulates a shift in positional values, or molecular-developmental identity, that caused a change in digit phenotype. The hypothesis synthesized developmental and paleontological data on wing digit homology. The "most anterior digit" (MAD) hypothesis presents an alternative view based on changes in transcriptional regulation in the limb. The molecular evidence for both hypotheses is that the MAD expresses Hoxd13 but not Hoxd11 and Hoxd12. This digit I "signature" is thought to characterize all amniotes. Here, we studied Hoxd expression patterns in a phylogenetic sample of 18 amniotes. Instead of a conserved molecular signature in digit I, we find wide variation of Hoxd11, Hoxd12, and Hoxd13 expression in digit I. Patterns of apoptosis, and Sox9 expression, a marker of the phalanx-forming region, suggest that phalanges were lost from wing digit IV because of early arrest of the phalanx-forming region followed by cell death. Finally, we show that multiple amniote lineages lost phalanges with no frameshift. Our findings suggest that the bird wing evolved by targeted loss of phalanges under selection. Consistent with our view, some recent phylogenies based on dinosaur fossils eliminate the need to postulate a frameshift in the first place. We suggest that the phenotype of the Archaeopteryx lithographica wing is also consistent with phalanx loss. More broadly, our results support a gradualist model of evolution based on tinkering with developmental gene expression.

Published
2021

5. Dactylogyrids (Platyhelminthes: Monogenea) from Sudanese Labeo spp., with a description of Dogielius sennarensis n. sp. and a redescription of Dogielius fl osculus Guégan, Lambert & Euzet, 1989

Author

27575934 - Prikrylová, Iva, Pravdová, M., Prikrylová, I., Ondracková, M., Blazek, R., Mahmoud, Z., 27575934 - Prikrylová, Iva, Pravdová, M., Prikrylová, I., Ondracková, M., Blazek, R., and Mahmoud, Z.

Abstract

Dactylogyrid monogeneans of Labeo horie Heckel, 1847 and L. niloticus (Linnaeus, 1758) (Cyprinidae) were surveyed at two sites on the River Nile in Sudan. The present study reports the presence of ten species of Dactylogyrus Diesing, 1850 and three species of Dogielius Bychowsky, 1936 based on a morphometric evaluation of the sclerotised structures. The species found include: Dactylogyrus nathaliae Guégan, Lambert & Euzet, 1988; D. rastellus Guégan, Lambert & Euzet, 1988; D. retroversus Guégan, Lambert & Euzet, 1988; D. senegalensis Paperna, 1969, D. yassensis Musilová, Rehulková & Gelnar, 2009 and five other undescribed species of Dactylogyrus. The genus Dogielius was represented by Dogielius flosculus Guégan, Lambert & Euzet, 1989; the newly identified D. sennarensis n. sp., and one undescribed Dogielius species. While D. sennarensis n. sp. resembles D. intorquens, it differs from this species and other congeners by having a longer ventral bar and anchor points and nosclerotised vagina. In addition, this study redescribes D. flosculus based on the morphology of specimens collected from L. horie. All specimens studied had a single large vagina, in contrast to the original description which reported a vagina composed of two unconnected parts. All dactylogyrid species in this study represent new host and geographical records

Published
2018

8. CTS (Karpal-Tunnel-Syndrom) als Folge eines direkten Traumas bei einem 10-jährigen Mädchen – ein Case Report

Author

Vossen, S, Janzen, J, and Blazek, R

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Anhand des ungewöhnlichen Erkrankungsalters und der ungewöhnlichen Ätiologie des Karpaltunnelsyndroms soll die Aufmerksamkeit auf das kindliche CTS gelenkt werden. Methodik: Ein 10-jähriges sonst vollständig gesundes Mädchen ohne wesentliche Vorerkrankungen[for full text, please go to the a.m. URL], 54. Kongress der Deutschen Gesellschaft für Handchirurgie

Published
2013
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10. Information needs of the rural physician: a descriptive study

Author

Dee, C and Blazek, R

Subjects
Research Article
Abstract

The study was designed to describe the information needs and the information-seeking behavior of rural physicians. Data were collected from twelve rural physicians in Central Florida through face-to-face interviews and observation. From a review of 144 patient charts, 48 produced unique, factual patient care questions. Seventy-five percent of the questions were on treatment, 14.7% on diagnosis, 8.3% on etiology, and 2.1% on the psychological aspects of disease. All physicians in the survey relied on colleagues; eleven attended medical meetings; nine subscribed to medical journals, and nine owned medical textbooks. Of the physicians with access to a hospital library, two used the library frequently while ten seldom used the library. Lack of time due to heavy workloads was an obstacle to systematic information retrieval. Rural physicians need immediate access to high-quality, synthesized answers to specific patient care questions at the time of patient contact. Information must be concise and up-to-date, although not necessarily state-of-the-art. A database composed of selected textbooks with integrated keyword access would meet the criteria. In addition, a computerized expert system focused on rural physicians' information needs is a possible remedy for the existing problem.

Published
1993

11. Dactylogyrids (Platyhelminthes: Monogenea) from Sudanese Labeo spp., with a description of Dogielius sennarensis n. sp. and a redescription of Dogielius fl osculus Guégan, Lambert & Euzet, 1989

Author

Pravdová M., Ondračková M., Přikrylová I., Blažek R., Mahmoud Z., and Gelnar M.

Subjects
dactylogyridae, dactylogyrus, dogielius, sudan, river nile, Microbiology, QR1-502
Abstract

Dactylogyrid monogeneans of Labeo horie Heckel, 1847 and L. niloticus (Linnaeus, 1758) (Cyprinidae) were surveyed at two sites on the River Nile in Sudan. The present study reports the presence of ten species of Dactylogyrus Diesing, 1850 and three species of Dogielius Bychowsky, 1936 based on a morphometric evaluation of the sclerotised structures. The species found include: Dactylogyrus nathaliae Guégan, Lambert & Euzet, 1988; D. rastellus Guégan, Lambert & Euzet, 1988; D. retroversus Guégan, Lambert & Euzet, 1988; D. senegalensis Paperna, 1969, D. yassensis Musilová, Řehulková & Gelnar, 2009 and five other undescribed species of Dactylogyrus. The genus Dogielius was represented by Dogielius flosculus Guégan, Lambert & Euzet, 1989; the newly identified D. sennarensis n. sp., and one undescribed Dogielius species. While D. sennarensis n. sp. resembles D. intorquens, it differs from this species and other congeners by having a longer ventral bar and anchor points and nosclerotised vagina. In addition, this study redescribes D. flosculus based on the morphology of specimens collected from L. horie. All specimens studied had a single large vagina, in contrast to the original description which reported a vagina composed of two unconnected parts. All dactylogyrid species in this study represent new host and geographical records.

Published
2018
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15. Creative accounting as a global tool for tax optimization

Author

Blazek Roman

Subjects
creative accounting, purposeful manipulation, tax optimization, falsification, signs of economic crime, Social Sciences
Abstract

Research background: Creative accounting is a set of skills that allow people to produce an artistic, scientific or other creative activity that creates new, unusual and acceptable ideas, which are transformed into financial statements, which then form a positive view of the company’s economic activities. Purpose of the article: Creative accounting is a problem all over the world, as it adversely affects the financial statements in each country. The article describes models that help reveal the creativity of accountants and financiers. Procedures for identifying possible accounting delays are based on analytical models. In particular, it is complex statistical methods or data collection techniques that identify hidden, unusual patterns that indicate fraud. These analytical models are therefore used to detect various errors and fraud in accounting. Methods: Analytical models will be available to identify different methods of accounting abuse. Interest is placed on the analytical models of Beneish model and the Modified Jones model. The main objective of using these models is to reveal creative accounting in sector A - Agriculture, forestry and fishing. Fraud is investigated using sophisticated analytical methods that reveal improved data. Findings & Value added: Creative accounting in the conditions of the Slovak Republic but also globally is still not possible completely to reveal. The value added of this article can be mentioned as the benefit for potential business partners as well as investors interested in the analysed sector and the other hand for the other for the state administration.

Published
2021
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16. Detection of earnings management in insurance companies in Slovakia

Author

Svabova Lucia and Blazek Roman

Subjects
beneish model, earnings manipulation, fraudulent financial reporting, Social Sciences
Abstract

Research background: Manipulation and the use of creative accounting or earnings management have become an increasingly popular topic in the history of researchers. Since 2002, this issue has attracted the attention of scientists and economists around the world. On the Slovak market, more than 30 insurance companies are actually operating, and some analyses have revealed that some of these insurance companies are engaging in activities that do not comply with the law. Purpose of the article: The article aims to use selected models for the detection of fraudulent financial reporting to determine whether there are unfair activities in insurance companies in Slovakia. At the same time, we evaluate the reliability of selected models and recommend the best models for this sector. Methods: Based on the set criteria, the Beneish model with five parameters and the Beneish model with eight parameters are applied to selected 20 companies in the Financial and Insurance activities sector to determine which companies have manipulated the financial statements. The analysis is performed using real data on Slovak companies from the Amadeus database. Findings & Value added: For the Financial and Insurance activities industry, we recommend using the Beneish model with eight parameters. Comparing the two models, we can conclude that this model is more accurate and thorough. The reason is also that this model works with more data from the financial statements.

Published
2021
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17. Cryptocurrencies: They´re really that lucrative?

Author

Blazek Roman

Subjects
cryptocurrencies, investing, alternative forms of investment, risk, return, Social Sciences
Abstract

Research background: Cryptocurrency is a digital currency that is intended for online trading. It uses and implements the principles of cryptography to create a distributed, decentralized and secure digital currency. Virtual money is a new and promising branch of the virtual economy that brings many advantages and disadvantages in a global sense. Many people have become involved in cryptocurrency hype because high investments in this digital money have been seized during the pandemic. The rise in revenues from this digital money has gripped the world globally. Purpose of the article: The basic purpose and chosen goal is to analyze the use of cryptomen trading during the global Covid-19 pandemic, as well as investing in these alternative sources of investment, which are gaining more attention every day precisely because of their freedom and detachment. Methods: The article will analyze data that will be compared based on the years before the Covid-19 pandemic and during the Covid-19 pandemic. Based on these data, the investment activity of people, companies, corporations is compared. Findings & Value added: Based on the results in the article, it was found that during the Covid-19 pandemic, the interest in investing in cryptocurrencies increased compared to the interest in investing in cryptocurrencies before the pandemic. The overall result is that people are moving to a new way of holding money, as cryptocurrencies are a new way to the future, as banks are unable to provide such returns from client deposits as cryptocurrencies, but they are associated with much greater risk.

Published
2021
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21. Demonstration of Combined Reliability Prediction and Verification Techniques to a Typical Flight Control System. Volume II. Tabular System Reliability Analysis (TASRA) Instruction Manual.

Author

BATTELLE MEMORIAL INST COLUMBUS OH COLUMBUS LABS, Blazek, R. H., Thomas, R. E., Easterday, J. L., BATTELLE MEMORIAL INST COLUMBUS OH COLUMBUS LABS, Blazek, R. H., Thomas, R. E., and Easterday, J. L.

Abstract

The report is Volume 2 of a three volume final report. The volume is a tutorial review of TAbular System Reliability Analysis (TASRA). The TASRA approach is discussed and examples are provie, See also Volume 1, AD-889 264L and Volume 3, AD-889 266L.

Published
1971

22. Demonstration of Combined Reliability Prediction and Verification Techniques to a Typical Flight Control System. Volume III. Tabular System Reliability Analysis Computer Output Data Sheets.

Author

BATTELLE MEMORIAL INST COLUMBUS OH COLUMBUS LABS, Blazek, R. H., Thomas, R. E., Thatcher, R. K., Easterday, J. L., BATTELLE MEMORIAL INST COLUMBUS OH COLUMBUS LABS, Blazek, R. H., Thomas, R. E., Thatcher, R. K., and Easterday, J. L.

Abstract

The report is Volume 3 of the final report on the subject contract consisting of computer printouts illustrating the actual format and output from the TASRA (Tabular System Reliability Analysis) program. These data are in support of the basic reliability and safety analysis of the pitch axis of the F-111 flight control system discussed in Volume 1 of this final report. Reliability and safety prediction calculations are tabulated for operating times of 2, 10, 100, and 1000 hours. (Author)

Published
1971

23. Demonstration of Combined Reliability Prediction and Verification Techniques to a Typical Flight Control System. Volume I. Development and Application of Tabular System Reliability Analysis to the F-111 Pitch Flight Control System.

Author

BATTELLE MEMORIAL INST COLUMBUS OH COLUMBUS LABS, Blazek, R. H., Levin, V., Thatcher, R. K., Thomas, R. E., Easterday, J. L., BATTELLE MEMORIAL INST COLUMBUS OH COLUMBUS LABS, Blazek, R. H., Levin, V., Thatcher, R. K., Thomas, R. E., and Easterday, J. L.

Abstract

The report is Volume 1 of a three volume final report describing the effort to satisfy the program's objective for refining and demonstrating the feasibility of a combined analytical prediction technique for reliability and safety. The technique is entitled 'TAbular System Reliability Analysis (TASRA)', which was previously reported in AFFDL-TR-70-81, AD877179. Feasibility of the technique is demonstrated using a typical modern control system, the F-111 triple redundant, adaptive, pitch axis flight control system. A TASRA digital computer program is written in FORTRAN language and is described in detail for both batch and terminal use. This Volume 1 describes the refinement and demonstration efforts including a comparison of TASRA predicted and field experience data for reliability and safety of the referenced system. (Author)

Published
1971

26. The sources of sex differences in aging in annual fishes

Author

Martin Reichard, Radim Blažek, Jakub Žák, Alessandro Cellerino, Matej Polačik, Reichard, M., Blazek, R., Zak, J., Cellerino, A., and Polacik, M.

Subjects
Male, Aging, Sex Characteristics, senescence, Nothobranchius furzeri, Animal, Longevity, adult sex ratio, Settore BIO/09 - Fisiologia, Cyprinodontiformes, social environment, Cyprinodontiforme, demographic ageing, gender, Animals, Female, Animal Science and Zoology, predation, Sex Ratio, Ecology, Evolution, Behavior and Systematics
Abstract

Intersexual differences in life span (age at death) and aging (increase in mortality risk associated with functional deterioration) are widespread among animals, from nematodes to humans. Males often live shorter than females, but there is substantial unexplained variation among species and populations. Despite extensive research, it is poorly understood how life span differences between the sexes are modulated by an interplay among genetic, environmental and social factors. The goal of our study was to test how sex differences in life span and ageing are modulated by social and environmental factors, and by intrinsic differences between males and females. To disentangle the complex basis of sex differences in life span and aging, we combined comparative data from sex ratios in 367 natural populations of four species of African annual killifish with experimental results on sex differences in life span and aging from eight laboratory populations tested in treatments that varied social and environmental conditions. In the wild, females consistently outlived males. In captivity, sex-specific mortality depended on social conditions. In social-housed experimental groups, male-biased mortality persisted in two aggressive species, but ceased in two placid species. When social and physical contacts were prevented by housing all fish individually, male-biased mortality ceased in all four species. This outcome held across benign and challenging environmental conditions. Fitting demographic survival models revealed that increased baseline mortality was primarily responsible for a shorter male life span in social-housing conditions. The timing and rate of aging were not different between the sexes. No marker of functional aging we recorded in our study (lipofuscin accumulation, proliferative changes in kidney and liver) differed between males and females, despite their previously confirmed association with functional aging in Nothobranchius killifish. We show that sex differences in life span and aging in killifish are driven by a combination of social and environmental conditions, rather than differential functional aging. They are primarily linked to sexual selection but precipitated through multiple processes (predation, social interference). This demonstrates how sex-specific mortality varies among species even within an ecologically and evolutionary discrete lineage and explains how external factors mediate this difference.

Published
2022

28. The Science Performance of JWST as Characterized in Commissioning

Author

Jane Rigby, Marshall Perrin, Michael McElwain, Randy Kimble, Scott Friedman, Matt Lallo, René Doyon, Lee Feinberg, Pierre Ferruit, Alistair Glasse, Marcia Rieke, George Rieke, Gillian Wright, Chris Willott, Knicole Colon, Stefanie Milam, Susan Neff, Christopher Stark, Jeff Valenti, Jim Abell, Faith Abney, Yasin Abul-Huda, D. Scott Acton, Evan Adams, David Adler, Jonathan Aguilar, Nasif Ahmed, Loïc Albert, Stacey Alberts, David Aldridge, Marsha Allen, Martin Altenburg, Javier Álvarez-Márquez, Catarina Alves de Oliveira, Greg Andersen, Harry Anderson, Sara Anderson, Ioannis Argyriou, Amber Armstrong, Santiago Arribas, Etienne Artigau, Amanda Arvai, Charles Atkinson, Gregory Bacon, Thomas Bair, Kimberly Banks, Jaclyn Barrientes, Bruce Barringer, Peter Bartosik, William Bast, Pierre Baudoz, Thomas Beatty, Katie Bechtold, Tracy Beck, Eddie Bergeron, Matthew Bergkoetter, Rachana Bhatawdekar, Stephan Birkmann, Ronald Blazek, Claire Blome, Anthony Boccaletti, Torsten Böker, John Boia, Nina Bonaventura, Nicholas Bond, Kari Bosley, Ray Boucarut, Matthew Bourque, Jeroen Bouwman, Gary Bower, Charles Bowers, Martha Boyer, Larry Bradley, Greg Brady, Hannah Braun, David Breda, Pamela Bresnahan, Stacey Bright, Christopher Britt, Asa Bromenschenkel, Brian Brooks, Keira Brooks, Bob Brown, Matthew Brown, Patricia Brown, Andy Bunker, Matthew Burger, Howard Bushouse, Steven Cale, Alex Cameron, Peter Cameron, Alicia Canipe, James Caplinger, Francis Caputo, Mihai Cara, Larkin Carey, Stefano Carniani, Maria Carrasquilla, Margaret Carruthers, Michael Case, Riggs Catherine, Don Chance, George Chapman, Stéphane Charlot, Brian Charlow, Pierre Chayer, Bin Chen, Brian Cherinka, Sarah Chichester, Zack Chilton, Taylor Chonis, Mark Clampin, Charles Clark, Kerry Clark, Dan Coe, Benee Coleman, Brian Comber, Tom Comeau, Dennis Connolly, James Cooper, Rachel Cooper, Eric Coppock, Matteo Correnti, Christophe Cossou, Alain Coulais, Laura Coyle, Misty Cracraft, Mirko Curti, Steven Cuturic, Katherine Davis, Michael Davis, Bruce Dean, Amy DeLisa, Wim deMeester, Nadia Dencheva, Nadezhda Dencheva, Joseph DePasquale, Jeremy Deschenes, Örs Hunor Detre, Rosa Diaz, Dan Dicken, Audrey DiFelice, Matthew Dillman, William Dixon, Jesse Doggett, Tom Donaldson, Rob Douglas, Kimberly DuPrie, Jean Dupuis, John Durning, Nilufar Easmin, Weston Eck, Chinwe Edeani, Eiichi Egami, Ralf Ehrenwinkler, Jonathan Eisenhamer, Michael Eisenhower, Michelle Elie, James Elliott, Kyle Elliott, Tracy Ellis, Michael Engesser, Nestor Espinoza, Odessa Etienne, Mireya Etxaluze, Patrick Falini, Matthew Feeney, Malcolm Ferry, Joseph Filippazzo, Brian Fincham, Mees Fix, Nicolas Flagey, Michael Florian, Jim Flynn, Erin Fontanella, Terrance Ford, Peter Forshay, Ori Fox, David Franz, Henry Fu, Alexander Fullerton, Sergey Galkin, Anthony Galyer, Macarena García Marín, Jonathan P. Gardner, Lisa Gardner, Dennis Garland, Bruce Garrett, Danny Gasman, Andras Gaspar, Daniel Gaudreau, Peter Gauthier, Vincent Geers, Paul Geithner, Mario Gennaro, Giovanna Giardino, Julien Girard, Mark Giuliano, Kirk Glassmire, Adrian Glauser, Stuart Glazer, John Godfrey, David Golimowski, David Gollnitz, Fan Gong, Shireen Gonzaga, Michael Gordon, Karl Gordon, Paul Goudfrooij, Thomas Greene, Matthew Greenhouse, Stefano Grimaldi, Andrew Groebner, Timothy Grundy, Pierre Guillard, Irvin Gutman, Kong Q. Ha, Peter Haderlein, Andria Hagedorn, Kevin Hainline, Craig Haley, Maryam Hami, Forrest Hamilton, Heidi Hammel, Carl Hansen, Tom Harkins, Michael Harr, Jessica Hart, Quyen Hart, George Hartig, Ryan Hashimoto, Sujee Haskins, William Hathaway, Keith Havey, Brian Hayden, Karen Hecht, Chris Heller-Boyer, Caroline Henriques, Alaina Henry, Karl Hermann, Scarlin Hernandez, Brigette Hesman, Brian Hicks, Bryan Hilbert, Dean Hines, Melissa Hoffman, Sherie Holfeltz, Bryan J. Holler, Jennifer Hoppa, Kyle Hott, Joseph M. Howard, Rick Howard, Alexander Hunter, David Hunter, Brendan Hurst, Bernd Husemann, Leah Hustak, Luminita Ilinca Ignat, Garth Illingworth, Sandra Irish, Wallace Jackson, Amir Jahromi, Peter Jakobsen, LeAndrea James, Bryan James, William Januszewski, Ann Jenkins, Hussein Jirdeh, Phillip Johnson, Timothy Johnson, Vicki Jones, Ron Jones, Danny Jones, Olivia Jones, Ian Jordan, Margaret Jordan, Sarah Jurczyk, Alden Jurling, Catherine Kaleida, Phillip Kalmanson, Jens Kammerer, Huijo Kang, Shaw-Hong Kao, Diane Karakla, Patrick Kavanagh, Doug Kelly, Sarah Kendrew, Herbert Kennedy, Deborah Kenny, Ritva Keski-kuha, Charles Keyes, Richard Kidwell, Wayne Kinzel, Jeff Kirk, Mark Kirkpatrick, Danielle Kirshenblat, Pamela Klaassen, Bryan Knapp, J. Scott Knight, Perry Knollenberg, Robert Koehler, Anton Koekemoer, Aiden Kovacs, Trey Kulp, Nimisha Kumari, Mark Kyprianou, Stephanie La Massa, Aurora Labador, Alvaro Labiano, Pierre-Olivier Lagage, Charles-Philippe Lajoie, Matthew Lallo, May Lam, Tracy Lamb, Scott Lambros, Richard Lampenfield, James Langston, Kirsten Larson, David Law, Jon Lawrence, David Lee, Jarron Leisenring, Kelly Lepo, Michael Leveille, Nancy Levenson, Marie Levine, Zena Levy, Dan Lewis, Hannah Lewis, Mattia Libralato, Paul Lightsey, Miranda Link, Lily Liu, Amy Lo, Alexandra Lockwood, Ryan Logue, Chris Long, Douglas Long, Charles Loomis, Marcos Lopez-Caniego, Jose Lorenzo Alvarez, Jennifer Love-Pruitt, Adrian Lucy, Nora Luetzgendorf, Peiman Maghami, Roberto Maiolino, Melissa Major, Sunita Malla, Eliot Malumuth, Elena Manjavacas, Crystal Mannfolk, Amanda Marrione, Anthony Marston, André Martel, Marc Maschmann, Gregory Masci, Michaela Masciarelli, Michael Maszkiewicz, John Mather, Kenny McKenzie, Brian McLean, Matthew McMaster, Katie Melbourne, Marcio Meléndez, Michael Menzel, Kaiya Merz, Michele Meyett, Luis Meza, Cherie Miskey, Karl Misselt, Christopher Moller, Jane Morrison, Ernie Morse, Harvey Moseley, Gary Mosier, Matt Mountain, Julio Mueckay, Michael Mueller, Susan Mullally, Jess Murphy, Katherine Murray, Claire Murray, David Mustelier, James Muzerolle, Matthew Mycroft, Richard Myers, Kaila Myrick, Shashvat Nanavati, Elizabeth Nance, Omnarayani Nayak, Bret Naylor, Edmund Nelan, Bryony Nickson, Alethea Nielson, Maria Nieto-Santisteban, Nikolay Nikolov, Alberto Noriega-Crespo, Brian O’Shaughnessy, Brian O’Sullivan, William Ochs, Patrick Ogle, Brenda Oleszczuk, Joseph Olmsted, Shannon Osborne, Richard Ottens, Beverly Owens, Camilla Pacifici, Alyssa Pagan, James Page, Sang Park, Keith Parrish, Polychronis Patapis, Lee Paul, Tyler Pauly, Cheryl Pavlovsky, Andrew Pedder, Matthew Peek, Maria Pena-Guerrero, Konstantin Penanen, Yesenia Perez, Michele Perna, Beth Perriello, Kevin Phillips, Martin Pietraszkiewicz, Jean-Paul Pinaud, Norbert Pirzkal, Joseph Pitman, Aidan Piwowar, Vera Platais, Danielle Player, Rachel Plesha, Joe Pollizi, Ethan Polster, Klaus Pontoppidan, Blair Porterfield, Charles Proffitt, Laurent Pueyo, Christine Pulliam, Brian Quirt, Irma Quispe Neira, Rafael Ramos Alarcon, Leah Ramsay, Greg Rapp, Robert Rapp, Bernard Rauscher, Swara Ravindranath, Timothy Rawle, Michael Regan, Timothy A. Reichard, Carl Reis, Michael E. Ressler, Armin Rest, Paul Reynolds, Timothy Rhue, Karen Richon, Emily Rickman, Michael Ridgaway, Christine Ritchie, Hans-Walter Rix, Massimo Robberto, Gregory Robinson, Michael Robinson, Orion Robinson, Frank Rock, David Rodriguez, Bruno Rodriguez Del Pino, Thomas Roellig, Scott Rohrbach, Anthony Roman, Fred Romelfanger, Perry Rose, Anthony Roteliuk, Marc Roth, Braden Rothwell, Neil Rowlands, Arpita Roy, Pierre Royer, Patricia Royle, Chunlei Rui, Peter Rumler, Joel Runnels, Melissa Russ, Zafar Rustamkulov, Grant Ryden, Holly Ryer, Modhumita Sabata, Derek Sabatke, Elena Sabbi, Bridget Samuelson, Benjamin Sapp, Bradley Sappington, B. Sargent, Arne Sauer, Silvia Scheithauer, Everett Schlawin, Joseph Schlitz, Tyler Schmitz, Analyn Schneider, Jürgen Schreiber, Vonessa Schulze, Ryan Schwab, John Scott, Kenneth Sembach, Clare Shanahan, Bryan Shaughnessy, Richard Shaw, Nanci Shawger, Christopher Shay, Evan Sheehan, Sharon Shen, Allan Sherman, Bernard Shiao, Hsin-Yi Shih, Irene Shivaei, Matthew Sienkiewicz, David Sing, Marco Sirianni, Anand Sivaramakrishnan, Joy Skipper, G. C. Sloan, Christine Slocum, Steven Slowinski, Erin Smith, Eric Smith, Denise Smith, Corbett Smith, Gregory Snyder, Warren Soh, Sangmo Tony Sohn, Christian Soto, Richard Spencer, Scott Stallcup, John Stansberry, Carl Starr, Elysia Starr, Alphonso Stewart, Massimo Stiavelli, Amber Straughn, David Strickland, Jeff Stys, Francis Summers, Fengwu Sun, Ben Sunnquist, Daryl Swade, Michael Swam, Robert Swaters, Robby Swoish, Joanna M. Taylor, Rolanda Taylor, Maurice Te Plate, Mason Tea, Kelly Teague, Randal Telfer, Tea Temim, Deepashri Thatte, Christopher Thompson, Linda Thompson, Shaun Thomson, Tuomo Tikkanen, William Tippet, Connor Todd, Sharon Toolan, Hien Tran, Edwin Trejo, Justin Truong, Chris Tsukamoto, Samuel Tustain, Harrison Tyra, Leonardo Ubeda, Kelli Underwood, Michael Uzzo, Julie Van Campen, Thomas Vandal, Bart Vandenbussche, Begoña Vila, Kevin Volk, Glenn Wahlgren, Mark Waldman, Chanda Walker, Michel Wander, Christine Warfield, Gerald Warner, Matthew Wasiak, Mitchell Watkins, Andrew Weaver, Mark Weilert, Nick Weiser, Ben Weiss, Sarah Weissman, Alan Welty, Garrett West, Lauren Wheate, Elizabeth Wheatley, Thomas Wheeler, Rick White, Kevin Whiteaker, Paul Whitehouse, Jennifer Whiteleather, William Whitman, Christina Williams, Christopher Willmer, Scott Willoughby, Andrew Wilson, Gregory Wirth, Emily Wislowski, Erin Wolf, David Wolfe, Schuyler Wolff, Bill Workman, Ray Wright, Carl Wu, Rai Wu, Kristen Wymer, Kayla Yates, Christopher Yeager, Jared Yeates, Ethan Yerger, Jinmi Yoon, Alice Young, Susan Yu, Dean Zak, Peter Zeidler, Julia Zhou, Thomas Zielinski, Cristian Zincke, Stephanie Zonak, Rigby, J., Perrin, M., Mcelwain, M., Kimble, R., Friedman, S., Lallo, M., Doyon, R., Feinberg, L., Ferruit, P., Glasse, A., Rieke, M., Rieke, G., Wright, G., Willott, C., Colon, K., Milam, S., Neff, S., Stark, C., Valenti, J., Abell, J., Abney, F., Abul-Huda, Y., Scott Acton, D., Adams, E., Adler, D., Aguilar, J., Ahmed, N., Albert, L., Alberts, S., Aldridge, D., Allen, M., Altenburg, M., Alvarez-Marquez, J., Alves de Oliveira, C., Andersen, G., Anderson, H., Anderson, S., Argyriou, I., Armstrong, A., Arribas, S., Artigau, E., Arvai, A., Atkinson, C., Bacon, G., Bair, T., Banks, K., Barrientes, J., Barringer, B., Bartosik, P., Bast, W., Baudoz, P., Beatty, T., Bechtold, K., Beck, T., Bergeron, E., Bergkoetter, M., Bhatawdekar, R., Birkmann, S., Blazek, R., Blome, C., Boccaletti, A., Boker, T., Boia, J., Bonaventura, N., Bond, N., Bosley, K., Boucarut, R., Bourque, M., Bouwman, J., Bower, G., Bowers, C., Boyer, M., Bradley, L., Brady, G., Braun, H., Breda, D., Bresnahan, P., Bright, S., Britt, C., Bromenschenkel, A., Brooks, B., Brooks, K., Brown, B., Brown, M., Brown, P., Bunker, A., Burger, M., Bushouse, H., Cale, S., Cameron, A., Cameron, P., Canipe, A., Caplinger, J., Caputo, F., Cara, M., Carey, L., Carniani, S., Carrasquilla, M., Carruthers, M., Case, M., Catherine, R., Chance, D., Chapman, G., Charlot, S., Charlow, B., Chayer, P., Chen, B., Cherinka, B., Chichester, S., Chilton, Z., Chonis, T., Clampin, M., Clark, C., Clark, K., Coe, D., Coleman, B., Comber, B., Comeau, T., Connolly, D., Cooper, J., Cooper, R., Coppock, E., Correnti, M., Cossou, C., Coulais, A., Coyle, L., Cracraft, M., Curti, M., Cuturic, S., Davis, K., Davis, M., Dean, B., Delisa, A., Demeester, W., Dencheva, N., Depasquale, J., Deschenes, J., Hunor Detre, I., Diaz, R., Dicken, D., Difelice, A., Dillman, M., Dixon, W., Doggett, J., Donaldson, T., Douglas, R., Duprie, K., Dupuis, J., Durning, J., Easmin, N., Eck, W., Edeani, C., Egami, E., Ehrenwinkler, R., Eisenhamer, J., Eisenhower, M., Elie, M., Elliott, J., Elliott, K., Ellis, T., Engesser, M., Espinoza, N., Etienne, O., Etxaluze, M., Falini, P., Feeney, M., Ferry, M., Filippazzo, J., Fincham, B., Fix, M., Flagey, N., Florian, M., Flynn, J., Fontanella, E., Ford, T., Forshay, P., Fox, O., Franz, D., Fu, H., Fullerton, A., Galkin, S., Galyer, A., Garcia Marin, M., Gardner, J. P., Gardner, L., Garland, D., Garrett, B., Gasman, D., Gaspar, A., Gaudreau, D., Gauthier, P., Geers, V., Geithner, P., Gennaro, M., Giardino, G., Girard, J., Giuliano, M., Glassmire, K., Glauser, A., Glazer, S., Godfrey, J., Golimowski, D., Gollnitz, D., Gong, F., Gonzaga, S., Gordon, M., Gordon, K., Goudfrooij, P., Greene, T., Greenhouse, M., Grimaldi, S., Groebner, A., Grundy, T., Guillard, P., Gutman, I., Ha, K. Q., Haderlein, P., Hagedorn, A., Hainline, K., Haley, C., Hami, M., Hamilton, F., Hammel, H., Hansen, C., Harkins, T., Harr, M., Hart, J., Hart, Q., Hartig, G., Hashimoto, R., Haskins, S., Hathaway, W., Havey, K., Hayden, B., Hecht, K., Heller-Boyer, C., Henriques, C., Henry, A., Hermann, K., Hernandez, S., Hesman, B., Hicks, B., Hilbert, B., Hines, D., Hoffman, M., Holfeltz, S., Holler, B. J., Hoppa, J., Hott, K., Howard, J. M., Howard, R., Hunter, A., Hunter, D., Hurst, B., Husemann, B., Hustak, L., Ilinca Ignat, L., Illingworth, G., Irish, S., Jackson, W., Jahromi, A., Jakobsen, P., James, L., James, B., Januszewski, W., Jenkins, A., Jirdeh, H., Johnson, P., Johnson, T., Jones, V., Jones, R., Jones, D., Jones, O., Jordan, I., Jordan, M., Jurczyk, S., Jurling, A., Kaleida, C., Kalmanson, P., Kammerer, J., Kang, H., Kao, S. -H., Karakla, D., Kavanagh, P., Kelly, D., Kendrew, S., Kennedy, H., Kenny, D., Keski-Kuha, R., Keyes, C., Kidwell, R., Kinzel, W., Kirk, J., Kirkpatrick, M., Kirshenblat, D., Klaassen, P., Knapp, B., Scott Knight, J., Knollenberg, P., Koehler, R., Koekemoer, A., Kovacs, A., Kulp, T., Kumari, N., Kyprianou, M., La Massa, S., Labador, A., Labiano, A., Lagage, P. -O., Lajoie, C. -P., Lam, M., Lamb, T., Lambros, S., Lampenfield, R., Langston, J., Larson, K., Law, D., Lawrence, J., Lee, D., Leisenring, J., Lepo, K., Leveille, M., Levenson, N., Levine, M., Levy, Z., Lewis, D., Lewis, H., Libralato, M., Lightsey, P., Link, M., Liu, L., Lo, A., Lockwood, A., Logue, R., Long, C., Long, D., Loomis, C., Lopez-Caniego, M., Lorenzo Alvarez, J., Love-Pruitt, J., Lucy, A., Luetzgendorf, N., Maghami, P., Maiolino, R., Major, M., Malla, S., Malumuth, E., Manjavacas, E., Mannfolk, C., Marrione, A., Marston, A., Martel, A., Maschmann, M., Masci, G., Masciarelli, M., Maszkiewicz, M., Mather, J., Mckenzie, K., Mclean, B., Mcmaster, M., Melbourne, K., Melendez, M., Menzel, M., Merz, K., Meyett, M., Meza, L., Miskey, C., Misselt, K., Moller, C., Morrison, J., Morse, E., Moseley, H., Mosier, G., Mountain, M., Mueckay, J., Mueller, M., Mullally, S., Murphy, J., Murray, K., Murray, C., Mustelier, D., Muzerolle, J., Mycroft, M., Myers, R., Myrick, K., Nanavati, S., Nance, E., Nayak, O., Naylor, B., Nelan, E., Nickson, B., Nielson, A., Nieto-Santisteban, M., Nikolov, N., Noriega-Crespo, A., O'Shaughnessy, B., O'Sullivan, B., Ochs, W., Ogle, P., Oleszczuk, B., Olmsted, J., Osborne, S., Ottens, R., Owens, B., Pacifici, C., Pagan, A., Page, J., Park, S., Parrish, K., Patapis, P., Paul, L., Pauly, T., Pavlovsky, C., Pedder, A., Peek, M., Pena-Guerrero, M., Penanen, K., Perez, Y., Perna, M., Perriello, B., Phillips, K., Pietraszkiewicz, M., Pinaud, J. -P., Pirzkal, N., Pitman, J., Piwowar, A., Platais, V., Player, D., Plesha, R., Pollizi, J., Polster, E., Pontoppidan, K., Porterfield, B., Proffitt, C., Pueyo, L., Pulliam, C., Quirt, B., Quispe Neira, I., Ramos Alarcon, R., Ramsay, L., Rapp, G., Rapp, R., Rauscher, B., Ravindranath, S., Rawle, T., Regan, M., Reichard, T. A., Reis, C., Ressler, M. E., Rest, A., Reynolds, P., Rhue, T., Richon, K., Rickman, E., Ridgaway, M., Ritchie, C., Rix, H. -W., Robberto, M., Robinson, G., Robinson, M., Robinson, O., Rock, F., Rodriguez, D., Rodriguez Del Pino, B., Roellig, T., Rohrbach, S., Roman, A., Romelfanger, F., Rose, P., Roteliuk, A., Roth, M., Rothwell, B., Rowlands, N., Roy, A., Royer, P., Royle, P., Rui, C., Rumler, P., Runnels, J., Russ, M., Rustamkulov, Z., Ryden, G., Ryer, H., Sabata, M., Sabatke, D., Sabbi, E., Samuelson, B., Sapp, B., Sappington, B., Sargent, B., Sauer, A., Scheithauer, S., Schlawin, E., Schlitz, J., Schmitz, T., Schneider, A., Schreiber, J., Schulze, V., Schwab, R., Scott, J., Sembach, K., Shanahan, C., Shaughnessy, B., Shaw, R., Shawger, N., Shay, C., Sheehan, E., Shen, S., Sherman, A., Shiao, B., Shih, H. -Y., Shivaei, I., Sienkiewicz, M., Sing, D., Sirianni, M., Sivaramakrishnan, A., Skipper, J., Sloan, G. C., Slocum, C., Slowinski, S., Smith, E., Smith, D., Smith, C., Snyder, G., Soh, W., Tony Sohn, S., Soto, C., Spencer, R., Stallcup, S., Stansberry, J., Starr, C., Starr, E., Stewart, A., Stiavelli, M., Straughn, A., Strickland, D., Stys, J., Summers, F., Sun, F., Sunnquist, B., Swade, D., Swam, M., Swaters, R., Swoish, R., Taylor, J. M., Taylor, R., Te Plate, M., Tea, M., Teague, K., Telfer, R., Temim, T., Thatte, D., Thompson, C., Thompson, L., Thomson, S., Tikkanen, T., Tippet, W., Todd, C., Toolan, S., Tran, H., Trejo, E., Truong, J., Tsukamoto, C., Tustain, S., Tyra, H., Ubeda, L., Underwood, K., Uzzo, M., Van Campen, J., Vandal, T., Vandenbussche, B., Vila, B., Volk, K., Wahlgren, G., Waldman, M., Walker, C., Wander, M., Warfield, C., Warner, G., Wasiak, M., Watkins, M., Weaver, A., Weilert, M., Weiser, N., Weiss, B., Weissman, S., Welty, A., West, G., Wheate, L., Wheatley, E., Wheeler, T., White, R., Whiteaker, K., Whitehouse, P., Whiteleather, J., Whitman, W., Williams, C., Willmer, C., Willoughby, S., Wilson, A., Wirth, G., Wislowski, E., Wolf, E., Wolfe, D., Wolff, S., Workman, B., Wright, R., Wu, C., Wu, R., Wymer, K., Yates, K., Yeager, C., Yeates, J., Yerger, E., Yoon, J., Young, A., Yu, S., Zak, D., Zeidler, P., Zhou, J., Zielinski, T., Zincke, C., Zonak, S., and bibliotheque, la.

Subjects
Science & Technology, Observatories, Infrared astronomy, Astronomical instrumentation, INFRARED SPECTROGRAPH NIRSPEC, FOS: Physical sciences, Astronomy and Astrophysics, Astronomy & Astrophysics, Settore FIS/05 - Astronomia e Astrofisica, Space and Planetary Science, Physical Sciences, Astrophysics - Instrumentation and Methods for Astrophysics, [PHYS.ASTR] Physics [physics]/Astrophysics [astro-ph], Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies., Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb293

Published
2022
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29. Limited scope for reproductive senescence in wild populations of a short-lived fish

Author

Jakub Žák, Alessandro Cellerino, Milan Vrtílek, Martin Reichard, Matej Polačik, Radim Blažek, Vrtilek, M., Zak, J., Blazek, R., Polacik, M., Cellerino, A., and Reichard, M.

Subjects
Male, 0106 biological sciences, 0301 basic medicine, Senescence, Aging, Plasticity, Longevity, Population, Captivity, Zoology, Animals, Wild, Population heterogeneity, 010603 evolutionary biology, 01 natural sciences, Nothobranchius furzeri, Cyprinodontiformes, 03 medical and health sciences, Reproductive senescence, Animals, Gene by environment interaction, Killifish, Gonads, education, Ecology, Evolution, Behavior and Systematics, Turquoise killifish, education.field_of_study, biology, Reproduction, General Medicine, biology.organism_classification, Fecundity, Reproductive ageing, 030104 developmental biology, Female
Abstract

Senescence in wild populations was long considered negligible but current evidence suggests that it is widespread in natural populations of mammals and birds, affecting the survival and reproductive output of older individuals. In contrast, little is known about reproductive senescence in species with asymptotic growth that can keep increasing their reproductive output as they grow older and larger. Using a cross-sectional study, we tested age-related decline in fecundity and relative allocation to reproduction in five wild populations of an annual killifish, Nothobranchius furzeri (Cyprinodontiformes). We did not detect any decline in absolute female egg production over their short lifespan in the wild. Relative fecundity (egg production controlled for female body mass) tended to decrease with age. This effect was driven primarily by a single population that survived 17weeks, almost twice as long as the median persistence of the other four study populations. There was no decrease in relative ovary mass while in males, relative testes mass actually increased with age. Intra-population variation in relative ovary mass increased in older females suggesting heterogeneity in individual trajectories of female reproductive allocation. Overall, we demonstrate that annual killifish do not experience significant age-related decline in reproductive functions during their very short lifespan in the wild despite the marked deterioration of gonad tissue detected in captivity.

Published
2018

32. Selection on Phalanx Development in the Evolution of the Bird Wing.

Author

de Bakker MAG, van der Vos W, de Jager K, Chung WY, Fowler DA, Dondorp E, Spiekman SNF, Chew KY, Xie B, Jiménez R, Bickelmann C, Kuratani S, Blazek R, Kondrashov P, Renfree MB, and Richardson MK

Subjects
Animals, Birds genetics, Birds metabolism, Extremities, Phylogeny, Dinosaurs anatomy & histology, Wings, Animal
Abstract

The frameshift hypothesis is a widely accepted model of bird wing evolution. This hypothesis postulates a shift in positional values, or molecular-developmental identity, that caused a change in digit phenotype. The hypothesis synthesized developmental and paleontological data on wing digit homology. The "most anterior digit" (MAD) hypothesis presents an alternative view based on changes in transcriptional regulation in the limb. The molecular evidence for both hypotheses is that the MAD expresses Hoxd13 but not Hoxd11 and Hoxd12. This digit I "signature" is thought to characterize all amniotes. Here, we studied Hoxd expression patterns in a phylogenetic sample of 18 amniotes. Instead of a conserved molecular signature in digit I, we find wide variation of Hoxd11, Hoxd12, and Hoxd13 expression in digit I. Patterns of apoptosis, and Sox9 expression, a marker of the phalanx-forming region, suggest that phalanges were lost from wing digit IV because of early arrest of the phalanx-forming region followed by cell death. Finally, we show that multiple amniote lineages lost phalanges with no frameshift. Our findings suggest that the bird wing evolved by targeted loss of phalanges under selection. Consistent with our view, some recent phylogenies based on dinosaur fossils eliminate the need to postulate a frameshift in the first place. We suggest that the phenotype of the Archaeopteryx lithographica wing is also consistent with phalanx loss. More broadly, our results support a gradualist model of evolution based on tinkering with developmental gene expression., (© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.)

Published
2021
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33. [Psammomatous tenosynovialitis of hand and forearm - three new cases].

Author

Janzen J, Bierbach U, Bignion D, Vossen S, and Blazek R

Subjects
Calcinosis diagnosis, Calcinosis pathology, Calcinosis surgery, Diagnosis, Differential, Elbow Joint pathology, Female, Finger Joint pathology, Humans, Middle Aged, Tenosynovitis pathology, Elbow Joint surgery, Finger Joint surgery, Tenosynovitis diagnosis, Tenosynovitis surgery, Wrist Joint pathology, Wrist Joint surgery
Abstract

We report about three new observations of psammomatous tenosynovialitis on hand and forearm and performed a review of literature. To the best of our knowledge cases 7, 8 and 9 in the medical literature are now published., (© Georg Thieme Verlag KG Stuttgart · New York.)

Published
2013
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34. The interaction between an introduced fish host and local parasite fauna: Neogobius kessleri in the middle Danube River.

Author

Ondracková M, Dávidová M, Blazek R, Gelnar M, and Jurajda P

Subjects
Animals, Geography, Rivers, Seasons, Slovakia, Biodiversity, Fish Diseases parasitology, Parasites classification, Parasites isolation & purification, Parasitic Diseases, Animal parasitology, Perciformes parasitology
Abstract

Parasite communities of introduced fish Neogobius kessleri Günther (Gobiidae) were studied at five localities in the Slovak section of the Danube River during 2002-2005. Thirty-three metazoan parasite species were identified. All fish were infected with at least two parasite species; most of the parasite species were generalists. At all sampling sites, high susceptibility to local parasites was observed. The parasite community was dominated by three parasite species: glochidia of Anodonta anatina, larval or subadult acanthocephalan Pomphorhynchus laevis, and larval nematode Raphidascaris acus. The infection of both A. anatina and P. laevis was affected by season and habitat type, with higher abundance in spring and more frequent occurrence of A. anatina in side channels and P. laevis in main river channels. At both the component and infracommunity levels, a more diverse parasite community was found in side channels. This habitat was dominated by actively transmitted parasites, whilst endoparasites were more abundant in fish from the main river channel. Larval stages of parasites dominated the endoparasite community at all sampling sites. The introduced N. kessleri was used as intermediate host for most of the recorded parasites, in some cases also as a paratenic host. Finally, the importance of gobies as suitable hosts for local non-native parasite species (Anguillicoloides crassus, Anodonta woodina, Hydrozetes lacustris) is discussed.

Published
2009
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35. Temporal and spatial distribution of glochidial larval stages of European unionid mussels (Mollusca: Unionidae) on host fishes.

Author

Blazek R and Gelnar M

Subjects
Animals, Gills parasitology, Larva growth & development, Seasons, Unionidae growth & development, Cyprinidae parasitology, Perches parasitology, Unionidae classification
Abstract

Glochidia are the larval stage of freshwater unionid mussels that parasitize the fins and gill apparatus of fish. A total of 22 fish species were examined for the presence of glochidia whose distribution on individual hosts was studied on three common fish species, the roach Rutilus rutilus (L.), perch Percafluviatilis L. and bitterling Rhodeus sericeus (Pallas). Between 1997 and 1999, the fish were obtained from the rivers Morava and Kyjovka and surrounding water pools in the Czech Republic. The glochidia of two genera, Unio and Anodonta, were found. Anodonta glochidia were observed on 10 fish species, Unio glochidia on 17 fish species. There was a difference in spatial distribution of glochidia on the body of the host fish. Unio glochidia were predominantly located on the gills, whereas most Anodonta glochidia were found on the fins, with the highest numbers of glochidia were observed on the margin of the pectoral fins. For the gill apparatus, Unio glochidia were found predominantly on the second and third arch. Anodonta glochidia were predominantly found during winter and spring (November-May), whereas Unio glochidia were more abundant during May and June. The number of glochidia was positively correlated with fish length in perch highly infected by Anodonta glochidia and perch infected by Unio glochidia. Of the three fish species, the highest occurrence of parasites was found on perch with fewer observed on roach. In spite of the close relationship between bitterling and unionid mussels, glochidiosis was rare on this fish species.

Published
2006
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36. Information needs of the rural physician: a descriptive study.

Author

Dee C and Blazek R

Subjects
Adult, Aged, Education, Medical, Education, Medical, Continuing, Female, Florida, Humans, Libraries, Hospital, Library Surveys, Male, Middle Aged, Periodicals as Topic, Practice Patterns, Physicians', Specialization, Information Services, Libraries, Medical, Rural Health
Abstract

The study was designed to describe the information needs and the information-seeking behavior of rural physicians. Data were collected from twelve rural physicians in Central Florida through face-to-face interviews and observation. From a review of 144 patient charts, 48 produced unique, factual patient care questions. Seventy-five percent of the questions were on treatment, 14.7% on diagnosis, 8.3% on etiology, and 2.1% on the psychological aspects of disease. All physicians in the survey relied on colleagues; eleven attended medical meetings; nine subscribed to medical journals, and nine owned medical textbooks. Of the physicians with access to a hospital library, two used the library frequently while ten seldom used the library. Lack of time due to heavy workloads was an obstacle to systematic information retrieval. Rural physicians need immediate access to high-quality, synthesized answers to specific patient care questions at the time of patient contact. Information must be concise and up-to-date, although not necessarily state-of-the-art. A database composed of selected textbooks with integrated keyword access would meet the criteria. In addition, a computerized expert system focused on rural physicians' information needs is a possible remedy for the existing problem.

Published
1993

37. Fast and simple procedure for the detection of cell culture mycoplasmas using a single monoclonal antibody.

Author

Blazek R, Schmitt K, Krafft U, and Hadding U

Subjects
Animals, Antigens, Bacterial analysis, Cells, Cultured, Epitopes analysis, Female, Fluorescent Antibody Technique, Mice, Mice, Inbred BALB C, Mycoplasma immunology, Antibodies, Monoclonal, Mycoplasma isolation & purification
Abstract

The detection of mycoplasmas in cell cultures is still a problem, especially in those laboratories in which the detection and identification of microorganisms is not established as a routine procedure. In our laboratory, monoclonal antibodies (mAbs) have been prepared to Acholeplasma laidlawii, Mycoplasma hyorhinis, Mycoplasma orale, Mycoplasma arginini and Mycoplasma salivarium. 30 mAbs were obtained and one of these, designated CCM-2, was shown to bind to all five mycoplasma species. It also bound to Mycoplasma fermentans, Mycoplasma hominis and to all wild types (n = 54), isolated from cell cultures submitted to our laboratory. The mAb was used in a immunofluorescent assay (IF) and the method correlated with the microbiological assay. Using this mAb immunofluorescent staining of cells is a fast and simple procedure for mycoplasma detection in cell cultures.

Published
1990
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38. Assessment of the biological stability of human thyroid stimulating hormone prepared by immunoaffinity chromatography.

Author

Blazek RW and Randles SC

Subjects
Animals, Chromatography, Affinity, Drug Stability, Mice, Mice, Inbred BALB C, Radioimmunoassay, Temperature, Thyrotropin immunology, Thyrotropin analysis
Abstract

This paper reports a comprehensive study of the biological stability of an immunoaffinity purified preparation of human thyroid stimulating hormone (TSH) and provides a reference against which future natural or synthetic preparations may be compared. The stability of the hormone preparation was investigated using the accelerated degradation method. The bioassay of the TSH was carried out in mice using a modified McKenzie method. Analysis of the results showed that the preparation was as stable as other TSH preparations purified by conventional methods.

Published
1989
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39. Cloning and expression of the Erwinia chrysanthemi asparaginase gene in Escherichia coli and Erwinia carotovora.

Author

Gilbert HJ, Blazek R, Bullman HM, and Minton NP

Subjects
DNA Restriction Enzymes, Electrophoresis, Polyacrylamide Gel, Erwinia enzymology, Escherichia coli enzymology, Gene Expression Regulation, Plasmids, Transformation, Bacterial, Asparaginase genetics, Cloning, Molecular, Erwinia genetics, Genes, Bacterial
Abstract

A genomic library of Erwinia chrysanthemi DNA was constructed in bacteriophage lambda 1059 and recombinants expressing Er. chrysanthemi asparaginase detected using purified anti-asparaginase IgG. The gene was subcloned on a 4.7 kb EcoRI DNA restriction fragment into pUC9 to generate the recombinant plasmid pASN30. The position and orientation of the asparaginase structural gene was determined by subcloning. The enzyme was produced at high levels in Escherichia coli (5% of soluble protein) and was shown to be exported to the periplasmic space. Purified asparaginase from E. coli cells carrying pASN30 was indistinguishable from the Erwinia enzyme on the basis of specific activity [660-700 units (mg protein)-1], pI value (8.5), and subunit molecular weight (32 X 10(3]. Expression of the cloned gene was subject to glucose repression in E. coli but was not significantly repressed by glycerol. Recombinant plasmids, containing the asparaginase gene, when introduced into Erwinia carotovora, caused increased synthesis of the enzyme (2-4 fold higher than the current production strain).

Published
1986
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40. Multicompartmental analysis of amino acids: II. Tryptophan in affective disorder.

Author

Shaw DM, Tidmarsh SF, Johnson AL, Michalakeas AC, Riley GJ, Blazek R, and Francis AF

Subjects
Adult, Aged, Antidepressive Agents therapeutic use, Bipolar Disorder blood, Depression blood, Female, Humans, Kinetics, Lithium therapeutic use, Male, Middle Aged, Protein Binding, Sex Factors, Stress, Psychological blood, Tryptophan metabolism
Abstract

Two of the tryptophan pools in the body and their associated fluxes, as defined by multicompartmental analysis, were studied in patients with unipolar affective disorder, bipolar patients (manic) and control subjects. The 2 pools were tentatively associated with extra- and intra-cellular compartments. The investigations were performed fasting and may have been mildly stressful. Under these conditions the concentration of tryptophan in plasma and perhaps amounts in the extracellular space were reduced in unipolar depression, with intermediate values after recovery. Some model parameters were lower in females than in males. The results in unipolar affective disorder were interpreted in terms of a previously presented hypothesis that this illness may result in an idiosyncratic response to stress in which patients are unable to maintain normal amounts of tryptophan in the body. In manic patients extracellular levels of tryptophan were unchanged but intracellular and total quantities of 'freely available' tryptophan may have been reduced.

Published
1978
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41. Improvement in the persistence of microbial asparaginase and glutaminase in the circulation of the rat by chemical modifications.

Author

Blazek R and Benbough JE

Subjects
Alcaligenes enzymology, Alkylation, Animals, Antineoplastic Agents blood, Chemical Phenomena, Chemistry, Erwinia enzymology, Escherichia coli enzymology, Half-Life, Lysine, Rats, Asparaginase blood, Glutaminase blood
Abstract

Three enzymes used in cancer chemotherapy (asparaginases from Escherichia coli and Erwinia carotovora and glutaminase from Achromobacter) were each reacted with four amino specific reagents (ethyl acetimidate, O-methylisourea, succinic anhydride, and formaldehyde/sodium borohydride). The half-lives of the modified enzymes measured in the blood of rats showed that guanidation, acetimidation and reductive alkylation were more likely to increase the persistence of the native enzymes than succinylation. However, the improvement in the persistence of any one enzyme after any one modification could not be predicted from the results with the others. It was concluded that changes in persistence caused by each modification were due to the different effects on the tertiary structure of each native enzyme. The advantages of chemical modification for increasing the persistence of enzymes over other methods such as encapsulation or aggregation are discussed.

Published
1981
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