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7. Access to publicly funded weight management services in England using routine data from primary and secondary care (2007-2020): An observational cohort study

Author

Coulman, Karen D., Margelyte, Ruta, Jones, Tim, Blazeby, Jane M., Macleod, John, Owen-Smith, Amanda, Parretti, Helen, Welbourn, Richard, Redaniel, Maria Theresa, and Judge, Andy

Subjects
Obesity -- Surgery, Medicine -- Practice, Comorbidity, Type 2 diabetes, Company business management, Biological sciences
Abstract

Background Adults living with overweight/obesity are eligible for publicly funded weight management (WM) programmes according to national guidance. People with the most severe and complex obesity are eligible for bariatric surgery. Primary care plays a key role in identifying overweight/obesity and referring to WM interventions. This study aimed to (1) describe the primary care population in England who (a) are referred for WM interventions and (b) undergo bariatric surgery and (2) determine the patient and GP practice characteristics associated with both. Methods and findings An observational cohort study was undertaken using routinely collected primary care data in England from the Clinical Practice Research Datalink linked with Hospital Episode Statistics. During the study period (January 2007 to June 2020), 1,811,587 adults met the inclusion criteria of a recording of overweight/obesity in primary care, of which 54.62% were female and 20.10% aged 45 to 54. Only 56,783 (3.13%) were referred to WM, and 3,701 (1.09% of those with severe and complex obesity) underwent bariatric surgery. Multivariable Poisson regression examined the associations of demographic, clinical, and regional characteristics on the likelihood of WM referral and bariatric surgery. Higher body mass index (BMI) and practice region had the strongest associations with both outcomes. People with BMI [greater than or equal to]40 kg/m.sup.2 were more than 6 times as likely to be referred for WM (10.05% of individuals) than BMI 25.0 to 29.9 kg/m.sup.2 (1.34%) (rate ratio (RR) 6.19, 95% confidence interval (CI) [5.99,6.40], p < 0.001). They were more than 5 times as likely to undergo bariatric surgery (3.98%) than BMI 35.0 to 40.0 kg/m.sup.2 with a comorbidity (0.53%) (RR 5.52, 95% CI [5.07,6.02], p < 0.001). Patients from practices in the West Midlands were the most likely to have a WM referral (5.40%) (RR 2.17, 95% CI [2.10,2.24], p < 0.001, compared with the North West, 2.89%), and practices from the East of England least likely (1.04%) (RR 0.43, 95% CI [0.41,0.46], p < 0.001, compared with North West). Patients from practices in London were the most likely to undergo bariatric surgery (2.15%), and practices in the North West the least likely (0.68%) (RR 3.29, 95% CI [2.88,3.76], p < 0.001, London compared with North West). Longer duration since diagnosis with severe and complex obesity (e.g., 1.67% of individuals diagnosed in 2007 versus 0.34% in 2015, RR 0.20, 95% CI [0.12,0.32], p < 0.001), and increasing comorbidities (e.g., 2.26% of individuals with 6+ comorbidities versus 1.39% with none (RR 8.79, 95% CI [7.16,10.79], p < 0.001) were also strongly associated with bariatric surgery. The main limitation is the reliance on overweight/obesity being recorded within primary care records to identify the study population. Conclusions Between 2007 and 2020, a very small percentage of the primary care population eligible for WM referral or bariatric surgery according to national guidance received either. Higher BMI and GP practice region had the strongest associations with both. Regional inequalities may reflect differences in commissioning and provision of WM services across the country. Multi-stakeholder qualitative research is ongoing to understand the barriers to accessing WM services and potential solutions. Together with population-wide prevention strategies, improved access to WM interventions is needed to reduce obesity levels., Author(s): Karen D. Coulman 1,2,3,*, Ruta Margelyte 4,5, Tim Jones 1,4,5, Jane M. Blazeby 2, John Macleod 2,3,4, Amanda Owen-Smith 1, Helen Parretti 6, Richard Welbourn 7, Maria Theresa Redaniel [...]

Published
2023
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8. Reprint of: 'A new framework for developing and evaluating complex interventions: update of Medical Research Council guidance'

Author

Skivington, Kathryn, primary, Matthews, Lynsay, additional, Simpson, Sharon Anne, additional, Craig, Peter, additional, Baird, Janis, additional, Blazeby, Jane M., additional, Boyd, Kathleen Anne, additional, Craig, Neil, additional, French, David P., additional, McIntosh, Emma, additional, Petticrew, Mark, additional, Rycroft-Malone, Jo, additional, White, Martin, additional, and Moore, Laurence, additional

Published
2024
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14. What are Patients told about Innovative Surgical Procedures? A Qualitative Synthesis of Seven Case Studies in the UK

Author

Elliott, Daisy, Ochieng, Cynthia A., Zahra, Jesmond, McNair, Angus G.K., Main, Barry G., Skilton, Anni, Blencowe, Natalie S., Cousins, Sian, Paramasivan, Sangeetha, Hoffmann, Christin, Donovan, Jenny L., Blazeby, Jane M, Benedetto, Umberto, Casswell, Edward J, Caputo, Massimo, Carter, Nicholas, Efstratios, Alexandridis, Henderson, Robert, Hewes, James, Howell, Jonathan, Messenger, David, Mercer, Stuart, Osborne, Alan, Patel, Nimesh, Toms, Andrew, and Wickham, Louisa

Published
2022
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17. Real-time monitoring and feedback to improve shared decision-making for surgery (the ALPACA Study): protocol for a mixed-methods study to inform co-development of an inclusive intervention

Author

Hoffmann, Christin, primary, Avery, Kerry N L, additional, Macefield, Rhiannon C, additional, Snelgrove, Val, additional, Blazeby, Jane M, additional, Hopkins, Della, additional, Hickey, Shireen, additional, Cabral, Christie, additional, Hall, Jennifer, additional, Gibbison, Ben, additional, Rooshenas, Leila, additional, Williams, Adam, additional, Aning, Jonathan, additional, Bekker, Hilary L, additional, and McNair, Angus G K, additional

Published
2024
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23. Development of a Reliable Surgical Quality Assurance System for 2-stage Esophagectomy in Randomized Controlled Trials

Author

Harris, Alexander, Butterworth, James, Boshier, Piers R., MacKenzie, Hugh, Tokunaga, Masanori, Sunagawa, Hideki, Mavroveli, Stella, Ni, Melody, Mikhail, Sameh, Yeh, Chi-Chuan, Blencowe, Natalie S., Avery, Kerry N. L., Hardwick, Richard, Hoelscher, Arnulf, Pera, Manuel, Zaninotto, Giovanni, Law, Simon, Low, Donald E., van Lanschot, Jan J. B., Berrisford, Richard, Barham, Christopher Paul, Blazeby, Jane M., and Hanna, George B.

Published
2022
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25. The QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation

Author

Rogers, Chris A., Andrews, Robert, Blazeby, Jane M., Byrne, James, Donovan, Jenny L., Kelly, Jamie, Mazza, Graziella, Mahon, David, Noble, Hamish, Reeves, Barnaby C., Thompson, Janice L., Wordsworth, Sarah, Welbourn, Richard, Beard, David, Carr, Andrew, Cook, Jonathan, Cooper, Cushla, Dean, Benjamin, Gray, Alastair, Gwilym, Stephen, Judge, Andrew, Merritt, Naomi, Moser, Jane, Rees, Jonathan, Rombach, Ines, Savulescu, Julian, Tracey, Irene, Wartolowska, Karolina, Harrison, Eleanor, Tan, Wei, Mills, Nicola, Karantana, Alexia, Sprange, Kirsty, Duley, Lelia, Elliott, Daisy, Hollingworth, William, Montgomery, Alan A., Davis, Tim, Stein, Rob, Bartlett, John, Cameron, David, Campbell, Amy, Canney, Peter, Dunn, Janet, Earl, Helena, Falzon, Mary, Francis, Adele, Hall, Peter, Harmer, Victoria, Higgins, Helen, Hiller, Louise, Hughes-Davies, Luke, Hulme, Claire, Macpherson, Iain, Makris, Andreas, Marshall, Andrea, McCabe, Christopher, Morgan, Adrienne, Pinder, Sarah, Poole, Christopher, Provenzano, Elena, Rea, Daniel, Stallard, Nigel, Avery, Kerry N.L., Barham, C. Paul, Berrisford, Richard, Elliott, Jackie, Falk, Stephen J., Goldin, Rob, Hanna, George, Hollowood, Andrew A., Krysztopik, Richard, Metcalfe, Chris, Noble, Sian, Sanders, Grant, Streets, Christopher G., Titcomb, Dan R., Wheatley, Tim, Rooshenas, Leila, Scott, Lauren J., Tilling, Kate M., Husbands, Samantha, Conefrey, Carmel, Stein, Robert C., Carr, Andrew J., Beard, David J., Paramasivan, Sangeetha, Jepson, Marcus, Avery, Kerry, and Wilson, Caroline

Published
2019
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26. Randomized controlled trials comparing gastric bypass, gastric band, and sleeve gastrectomy: A systematic review examining validity and applicability to wider clinical practice.

Author

Chalmers, Katy A., Cousins, Sian E., and Blazeby, Jane M.

Subjects
GASTRIC banding, SLEEVE gastrectomy, RANDOMIZED controlled trials, GASTRIC bypass, BARIATRIC surgery, CLINICAL trials
Abstract

Summary: Consideration of how applicable the results of surgical trials are to clinical practice is important to inform decision‐making. Randomized controlled trials comparing at least two surgical interventions (of gastric bypass, gastric band, and sleeve gastrectomy) for severe and complex obesity were examined using the PRagmatic Explanatory Continuum Indicator Summary‐2 tool, to consider how applicable the trial results are to clinical practice, and the Risk of Bias 2 tool, to examine validity. MEDLINE, Embase, and CENTRAL databases were searched for studies published between November 2013 and June 2021, and 15 were identified. Using the PRagmatic Explanatory Continuum Indicator Summary‐2 tool, three were classified as pragmatic, with good applicability to clinical practice. Ten had more explanatory domains but did include some pragmatic characteristics, and two were predominantly explanatory. This was due to some trial design features that would not be considered applicable to the wider clinical setting, including being single‐centered, having prescribed intervention delivery methods, and intensive follow‐up regimens. Only two trials had low risk of bias, of which one was considered pragmatic. Three had high risk of bias. Overall, few trials in bariatric surgery are pragmatic with low risk of bias. Well‐designed pragmatic trials are needed to inform practice and reduce research waste. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Laparoscopic or open abdominal surgery with thoracotomy for patients with oesophageal cancer: ROMIO randomized clinical trial.

Author

Akhtar, Khurshid, Alkhaffaf, Bilal, Ariyarathenam, Arun, Avery, Kerry, Barham, Paul, Bateman, Adrian, Beard, Chloe, Berrisford, Richard, Blazeby, Jane M, Blencowe, Natalie, Boddy, Alex, Bowrey, David, Bracey, Tim, Brierley, Rachel C, Briton, Kate, Byrne, James, Catton, James, Chaparala, Ram, Clark, Sarah K, and Clarke, Tonia

Subjects
ESOPHAGEAL cancer, ABDOMINAL surgery, THORACOTOMY, CANCER patients, VIDEO-assisted thoracic surgery, RECTAL surgery, CLINICAL trials
Abstract

Objective: This study investigated if hybrid oesophagectomy with minimally invasive gastric mobilization and thoracotomy enabled faster recovery than open surgery. Methods: In eight UK centres, this pragmatic RCT recruited patients for oesophagectomy to treat localized cancer. Participants were randomly allocated to hybrid or open surgery, stratified by centre and receipt of neoadjuvant treatment. Large dressings aimed to mask patients to their allocation for six days post-surgery. The authors present the intention-to-treat analysis of outcome measures from the first 3 months post-randomization, including the primary outcome, the patient-reported physical function scale of the EORTC QLQ-C30, and cost-effectiveness. Current Controlled Trials registration: ISRCTN 59036820 (feasibility study), 10386621 (definitive study). Findings: There was no evidence of a difference between hybrid (n = 267) and open (n = 266) surgery in average physical function over 3 months post-randomization: difference in means 2.1, 95% c.i. −2.0 to 6.2, P = 0.3. Complication rates were similar; for example, 88 (34%) participants in the open and 82 (32%) participants in the hybrid surgery groups experienced a pulmonary infection within 30 days. There was no evidence that hybrid surgery was more cost-effective than open surgery at 3 months. Conclusions: Patient-reported physical function in the 3 months post-randomization provided no evidence of a difference in recovery time between hybrid and open surgery, or a difference in cost-effectiveness. Both approaches to surgery were completed safely, with a similar risk of key complications, suggesting that surgeons who have a preference for one of the two approaches need not change their practice. This pragmatic randomized controlled trial conducted in eight UK centres allocated patients with localized oesophageal cancer to hybrid oesophagectomy with minimally invasive gastric mobilization and thoracotomy, or open surgery. The primary outcome was patient-reported recovery in the 3 months following allocation, measured using the EORTC QLQ-C30 physical function subscale. We found no evidence of a difference in recovery time between hybrid and open surgery, and a similar risk of key complications. [ABSTRACT FROM AUTHOR]

Published
2024
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30. An observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded randomized clinical trial recruitment

Author

Beard, David, Carr, Andrew, Cook, Jonathan, Cooper, Cushla, Dean, Benjamin, Donovan, Jenny L., Gray, Alastair, Gwilym, Stephen, Judge, Andrew, Merritt, Naomi, Moser, Jane, Rees, Jonathan, Rombach, Ines, Savulescu, Julian, Tracey, Irene, Wartolowska, Karolina, Blazeby, Jane M., Barham, Paul, Brookes, Sara T., Crosby, Tom, Falk, Stephen J., Griffin, S. Michael, Hollingworth, William, Hollowood, Andrew D., Krysztopik, Richard, Lewis, Wyn, Nicklin, Jo, Streets, Christopher, Strong, Sean, Titcomb, Dan, Williams, Geraint, Birtle, Alison, Bryan, Rik, Catto, James, Chester, John, French, Ann, Hall, Emma, Harris, Chris, Johnson, Mark, Jones, Rob, Keeley, Francis, Kirkbank, Tony, Kockelbergh, Roger, Lewis, Rebecca, Newton, Michelle, Powles, Thomas, Waters, Rachel, Winterbottom, Andrew, Halliday, Alison, Becquemin, Jean-Pierre, Belli, Anna, Bosiers, Marc, Cao, Piergiorgio, Davies, Christina, Gough, Michael, Hayter, Elizabeth, Leopold, Peter, McDonald, Sumaira, Michaels, Jonathan, Mihaylova, Borislava, Peto, Richard, Robertson, Steven, Rothwell, Peter, Scott, Rachael, Thomas, Dafydd, Vermassen, Frank, Stein, Rob, Bartlett, John, Cameron, David, Campbell, Amy, Canney, Peter, Dunn, Janet, Earl, Helena, Falzon, Mary, Francis, Adele, Hall, Peter, Harmer, Victoria, Higgins, Helen, Hiller, Louise, Hughes-Davies, Luke, Hulme, Claire, Macpherson, Iain, Makris, Andreas, Marshall, Andrea, McCabe, Christopher, Morgan, Adrienne, Pinder, Sarah, Poole, Christopher, Rea, Daniel, Stallard, Nigel, Jepson, Marcus, Elliott, Daisy, Conefrey, Carmel, Wade, Julia, Rooshenas, Leila, and Wilson, Caroline

Published
2018
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35. Variation in the provision and practice of implant-based breast reconstruction in the UK: Results from the iBRA national practice questionnaire

Author

Barnes, N.L.P., Blazeby, J.M., Branford, O.A., Conroy, E.J., Cutress, R.I., Gardiner, M.D., Holcombe, C., Jain, A., McEvoy, K., Mills, N., Mylvaganam, S., Potter, S., Skillman, J.M., Teasdale, E.M., Thrush, S., Whisker, L.J., Williamson, P.R., Tang, L., Nguyen, D., Johnson, R., Muralikrishnan, V., Chopra, S., Reid, A., Benyon, S., Murphy, C., Soliman, F., Lefemine, V., Saha, S., Ogedegbe, K., Olyinka, O.S., Dicks, J.R., Manoloudakis, N., Conroy, F., Irwin, G., McIntosh, S., Michalakis, I., Hignett, S., Linforth, R., Rathinaezhil, R., Osman, H., Anesti, K., Griffiths, M., Jacklin, R., Waterworth, A., Foulkes, R., Davies, E., Bisarya, K., Allan, A., Leon-Villapalos, J., Mazari, F.A.K., Azmy, I., George, S., Fahmy, F.S., Hargreaves, A., Seward, J., Henton, J., Collin, T., Mallon, P., Turner, J., Sarakbi, W., Athanasiou, I., Rogers, C., Youssef, M., Graja, T., Huf, S., Deol, H., Brindle, R., Gawne, S., Egbeare, D., Dash, I., Galea, M., Laws, S., Tayeh, S., Parvanta, L., Down, S., Westbroek, D., Roberts, J.W., Massey, J., Turton, P., Achuthan, R., Fawzy, M., Dickson, M., Carmichael, A.R., Akingboye, A., James, R., Kirkpatrick, K., Nael, E., Vidya, R., Thorne, A., Rostom, M., Depasquale, I., Cawthorn, S.J., Gangamihardja, T., Joglekar, S., Smith, J., Halka, A., MacMillan, D., Clark, S., Pearce, B., Mansfield, L., King, I., Hazari, A., Smith, B., Volleamere, A.J., Ferguson, D., Barnes, N., Knight, A., MacNeill, F., Conway, A., Irvine, T., Mylavaganam, S., Dunne, N., Kohlhardt, S., Hoo, C., Kirk, S., Hu, J., Ledwidge, S., Tang, S., Banerjee, D., Waheed, S., Voynov, V., Soumian, S., Henderson, J., Harvey, J., Robertson, S., Waters, R., Carbone, A., Skillman, J., Farooq, Ansar, Tafazal, H., Clarke, D., Cocker, D., Lai, L.M., Winter Beatty, J., Barkeji, M., Vinayagam, R., Mullan, M., Osborne, C., Baker, E., Piper, J., Mylvaganam, Senthurun, Conroy, Elizabeth, Williamson, Paula R., Barnes, Nicola L.P., Cutress, Ramsey I., Gardiner, Matthew D., Jain, Abhilash, Skillman, Joanna M., Thrush, Steven, Whisker, Lisa J., Blazeby, Jane M., Potter, Shelley, and Holcombe, Christopher

Published
2017
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36. Peri-operative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma (UK Medical Research Council ST03): primary analysis results of a multicentre, open-label, randomised phase 2–3 trial

Author

Cunningham, David, Stenning, Sally P, Smyth, Elizabeth C, Okines, Alicia F, Allum, William H, Rowley, Sam, Stevenson, Laura, Grabsch, Heike I, Alderson, Derek, Crosby, Thomas, Griffin, S Michael, Mansoor, Wasat, Coxon, Fareeda Y, Falk, Stephen J, Darby, Suzanne, Sumpter, Kate A, Blazeby, Jane M, and Langley, Ruth E

Published
2017
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41. Definitions, acceptability, limitations, and guidance in the use and reporting of surrogate endpoints in trials:A scoping review

Author

Manyara, Anthony M, Davies, Philippa, Stewart, Derek, Weir, Christopher J, Young, Amber E, Wells, Valerie, Blazeby, Jane M, Butcher, Nancy J., Bujkiewicz, Sylwia, Chan, An-Wen, Collins, Gary S., Dawoud, Dalia, Offringa, Martin, Ouwens, Mario, Ross, Joseph S, Taylor, Rod S., and Ciani, Oriana

Abstract

Highlights90 documents were included: 79% (n=71) had data on definitions, 77% (n=69) on acceptability, 72% (n=65) on limitations and challenges, and 61% (n=55) on guidance for design/reporting of surrogate endpoints in trials.There was heterogeneity in how surrogate endpoints were defined.Key recommendation identified was the need to justify use of a surrogate endpoint using evidence of validation.Another key recommendation of this review was increased involvement of patients and public in trials that use surrogate endpoints.Synthesised items on the use of surrogate endpoints in trials from the review will inform the SPIRIT-SURROGATE and CONSORT-SURROGATE extensions.

Published
2023

42. Patient-Reported Outcomes 12 Years after Localized Prostate Cancer Treatment

Author

Donovan, Jenny L., primary, Hamdy, Freddie C., additional, Lane, J. Athene, additional, Young, Grace J., additional, Metcalfe, Chris, additional, Walsh, Eleanor I., additional, Davis, Michael, additional, Steuart-Feilding, Thomas, additional, Blazeby, Jane M., additional, Avery, Kerry N. L., additional, Martin, Richard M., additional, Bollina, Prasad, additional, Doble, Andrew, additional, Doherty, Alan, additional, Gillatt, David, additional, Gnanapragasam, Vincent, additional, Hughes, Owen, additional, Kockelbergh, Roger, additional, Kynaston, Howard, additional, Paul, Alan, additional, Paez, Edgar, additional, Powell, Phillip, additional, Rosario, Derek J., additional, Rowe, Edward, additional, Mason, Malcolm, additional, Catto, James W. F., additional, Peters, Tim J., additional, Wade, Julia, additional, Turner, Emma L., additional, Williams, Naomi J., additional, Oxley, Jon, additional, Staffurth, John, additional, Bryant, Richard J., additional, and Neal, David E., additional

Published
2023
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45. Preoperative risk factors for conversion from laparoscopic to open cholecystectomy: a validated risk score derived from a prospective U.K. database of 8820 patients

Author

Fenwick, Stephen, Elmasry, Mohamed, Nunes, Quentin, Kennedy, David, Khan, Raja B., Khan, Muhammad A.S., Magee, Conor J., Jones, Steven M., Mason, Denise, Parappally, Ciny P., Mathur, Pawan, Saunders, Michael, Jamel, Sara, Haque, Samer U.l., Zafar, Sara, Shiwani, Muhammad H., Samuel, Nehemiah, Dar, Farooq, Jackson, Andrew, Lovett, Bryony, Dindyal, Shiva, Winter, Hannah, Rahman, Saquib, Wheatley, Kevin, Nieto, Tom, Ayaani, Soofiyah, Youssef, Haney, Nijjar, Rajwinder S., Watkin, Helen, Naumann, David, Emeshi, Sophie, Sarmah, Piyush B., Lee, Kathryn, Joji, Nikita, Heath, Jonathan, Teasdale, Rebecca L., Weerasinghe, Chamindri, Needham, Paul J., Welbourn, Hannah, Forster, Luke, Finch, David, Blazeby, Jane M., Robb, William, McNair, Angus G.K., Hrycaiczuk, Alex, Charalabopoulos, Alexandros, Kadirkamanathan, Sritharan, Tang, Cheuk-Bong, Jayanthi, Naga V.G., Noor, Nigel, Dobbins, Brian, Cockbain, Andrew J., Nilsen-Nunn, April, de Siqueira, Jonathan, Pellen, Mike, Cowley, Jonathan B., Ho, Wei-Min, Miu, Victor, White, Timothy J., Hodgkins, Kathryn A., Kinghorn, Alison, Tutton, Matthew G., Al-Abed, Yahya A., Menzies, Donald, Ahmad, Anwar, Reed, Joanna, Khan, Shabuddin, Monk, David, Vitone, Louis J., Murtaza, Ghulam, Joel, Abraham, Brennan, Stephen, Shier, David, Zhang, Catherine, Yoganathan, Thusidaran, Robinson, Steven J., McCallum, Iain J.D., Jones, Michael J., Elsayed, Mohammed, Tuck, Liz, Wayman, John, Carney, Kate, Aroori, Somaiah, Hosie, Kenneth B., Kimble, Adam, Bunting, David M., Fawole, Adeshina S., Basheer, Mohammed, Dave, Rajiv V., Sarveswaran, Janahan, Jones, Elinor, Kendal, Chris, Tilston, Michael P., Gough, Martin, Wallace, Tom, Singh, Shailendra, Downing, Justine, Mockford, Katherine A., Issa, Eyad, Shah, Nayab, Chauhan, Neal, Wilson, Timothy R., Forouzanfar, Amir, Wild, Jonathan R.L., Nofal, Emma, Bunnell, Catherine, Madbak, Khaliel, Rao, Sudhindra T.V., Devoto, Laurence, Siddiqi, Najaf, Khawaja, Zechan, Hewes, James C., Gould, Laura, Chambers, Alice, Rodriguez, Daniel U., Sen, Gourab, Robinson, Stuart, Bartlett, Francis, Rae, David M., Stevenson, Thomas E.J., Sarvananthan, Kas, Dwerryhouse, Simon J., Higgs, Simon M., Old, Oliver J., Hardy, Thomas J., Shah, Reena, Hornby, Steve T., Keogh, Ken, Frank, Lucinda, Al-Akash, Musallam, Upchurch, Emma A., Frame, Richard J., Hughes, Michael, Jelley, Clare, Weaver, Simon, Roy, Sudipta, Sillo, Toritseju O., Galanopoulos, Giorgios, Cuming, Tamzin, Cunha, Pedro, Tayeh, Salim, Kaptanis, Sarantos, Heshaishi, Mohamed, Eisawi, Abdalla, Abayomi, Michael, Ngu, Wee S., Fleming, Katie, Bajwa, Dalvir S., Chitre, Vivek, Aryal, Kamal, Ferris, Paul, Silva, Michael, Lammy, Simon, Mohamed, Sarah, Khawaja, Amir, Hussain, Adnan, Ghazanfar, Mudassar A., Bellini, Maria I., Ebdewi, Hamdi, Elshaer, Mohamed, Gravante, Gianpiero, Drake, Benjamin, Ogedegbe, Arikoge, Mukherjee, Dipankar, Arhi, Chanpreet, Giwa, Lola, Iqbal, Nusrat, Watson, Nicholas F., Aggarwal, Smeer K., Orchard, Philippa, Villatoro, Eduardo, Willson, Peter D., Mok, Kam W.J., Woodman, Thomas, Deguara, Jean, Garcea, Giuseppe, Babu, Benoy I., Dennison, Alistair R., Malde, Deep, Lloyd, David, Slavin, John P., Jones, Robert P., Ballance, Laura, Gerakopoulos, Stratos, Jambulingam, Periyathambi, Mansour, Sami, Sakai, Naomi, Acharya, Vikas, Sadat, Mohammed M., Karim, Lawen, Larkin, David, Amin, Khalid, Khan, Amarah, Law, Jennifer, Jamdar, Saurabh, Smith, Stella R., Sampat, Keerthika, O'shea, Kathryn M., Manu, Mangta, Asprou, Fotini M., Malik, Nabeela S., Chang, Jessica, Johnstone, Marianne, Lewis, Michael, Roberts, Geoffrey P., Karavadra, Babu, Photi, Evangelos, Hewes, James, Rodriguez, Dan, O'Reilly, Derek A., Rate, Anthony J., Sekhar, Hema, Henderson, Lucy T., Starmer, Benjamin Z., Coe, Peter O., Tolofari, Sotonye, Barrie, Jenifer, Bashir, Gareth, Sloane, Jake, Madanipour, Suroosh, Halkias, Constantine, Trevatt, Alexander E.J., Borowski, David W., Hornsby, Jane, Courtney, Michael J., Virupaksha, Suvi, Seymour, Keith, Robinson, Sarah, Hawkins, Helen, Bawa, Sadiq, Gallagher, Paul V., Reid, Alistair, Wood, Peter, Finch, Jonathan G., Finch, J.Guy, Parmar, Jitesh, Stirland, Euan, Gardner-Thorpe, James, Al-Muhktar, Ahmed, Peterson, Mark, Majeed, Ali, Bajwa, Farrukh M., Martin, Jack, Choy, Alfred, Tsang, Andrew, Pore, Naresh, Andrew, David R., Al-Khyatt, Waleed, Santosh Bhandari, Christopher Taylor, Chambers, Adam, Subramanium, Dhivya, Toh, Simon K.C., Carter, Nicholas C., Mercer, Stuart J., Knight, Benjamin, Vijay, Vardhini, Alagaratnam, Swethan, Sinha, Sidhartha, Khan, Shahab, El-Hasani, Shamsi S., Hussain, Abdulzahra A., Bhattacharya, Vish, Kansal, Nisheeth, Fasih, Tani, Jackson, Claire, Siddiqui, Midhat N., Chishti, Imran A., Fordham, Imogen J., Siddiqui, Zohaib, Bausbacher, Harald, Geogloma, Ileana, Gurung, Kabita, Tsavellas, George, Basynat, Pradeep, Shrestha, Ashish K., Basu, Sanjoy, Chhabra, Alok, Harilingam, Mohan, Rabie, Mohamed, Akhtar, Mansoor, Kumar, Pradeep, Jafferbhoy, Sadaf F., Hussain, Najam, Raza, Soulat, Haque, Manzarul, Alam, Imran, Aseem, Rabiya, Patel, Shakira, Asad, Mehek, Booth, Michael I., Ball, William R., Wood, Christopher P.J., Pinho-Gomes, Ana C., Kausar, Ambareen, Obeidallah, Mohammed, Varghase, Joseph, Lodhia, Joshil, Bradley, Donal, Rengifo, Carla, Lindsay, David, Gopalswamy, Sivakumar, Finlay, Ian, Wardle, Stacy, Bullen, Naomi, Iftikhar, Syed Y., Awan, Altaf, Ahmed, Javed, Leeder, Paul, Fusai, Guiseppe, Bond-Smith, Giles, Psica, Alicja, Puri, Yogesh, Hou, David, Noble, Fergus, Szentpali, Karoly, Broadhurst, Jack, Date, Ravindra, Hossack, Martin R., Goh, Yan L., Turner, Paul, Shetty, Vinutha, Riera, Manel, Macano, Christina A.W., Sukha, Anisha, Preston, Shaun R., Hoban, Jennifer R., Puntis, Daniel J., Williams, Sophie V., Krysztopik, Richard, Kynaston, James, Batt, Jeremy, Doe, Matthew, Goscimski, Andrzej, Jones, Gareth H., Hall, Claire, Carty, Nick, Ahmed, Jamil, Panteleimonitis, Sofoklis, Gunasekera, Rohan T., Sheel, Andrea R.G., Lennon, Hannah, Hindley, Caroline, Reddy, Marcus, Kenny, Ross, Elkheir, Natalie, McGlone, Emma R., Rajaganeshan, Rajasundaram, Hancorn, Kate, Hargreaves, Anita, Prasad, Raj, Longbotham, David A., Vijayanand, Dhakshinamoorthy, Wijetunga, Imeshi, Ziprin, Paul, Nicolay, Christopher R., Yeldham, Geoffrey, Read, Edward, Gossage, James A., Rolph, Rachel C., Ebied, Husam, Phull, Manraj, Khan, Mohammad A., Popplewell, Matthew, Kyriakidis, Dimitrios, Hussain, Anwar, Henley, Natasha, Packer, Jessica R., Derbyshire, Laura, Porter, Jonathan, Appleton, Shaun, Farouk, Marwan, Basra, Melvinder, Jennings, Neil A., Ali, Shahda, Kanakala, Venkatesh, Ali, Haythem, Lane, Risha, Dickson-Lowe, Richard, Zarsadias, Prizzi, Mirza, Darius, Puig, Sonia, Al Amari, Khalid, Vijayan, Deepak, Sutcliffe, Robert, Marudanayagam, Ravi, Hamady, Zayed, Prasad, Abheesh R., Patel, Abhilasha, Durkin, Damien, Kaur, Parminder, Bowen, Laura, Byrne, James P., Pearson, Katherine L., Delisle, Theo G., Davies, James, Tomlinson, Mark A., Johnpulle, Michelle 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Published
2016
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49. Cost-Effectiveness of Video-Assisted Thoracoscopic Surgery Compared to Open Lobectomy in Patients with Early-Stage Lung Cancer: Findings from the VIOLET Randomised Controlled Trial

Author

Stokes, Elizabeth A, primary, Harris, Rosie A., additional, Dabner, Lucy, additional, McKeon, Holly E., additional, Kaur, Surinder, additional, Paramasivan, Sangeetha, additional, Realpe, Alba, additional, Elliott, Daisy, additional, Batchelor, Tim J.P., additional, Dunning, Joel, additional, Shackcloth, Michael, additional, Anikin, Vladimir, additional, Naidu, Babu, additional, Belcher, Elizabeth, additional, Loubani, Mahmoud, additional, Zamvar, Vipin, additional, De Sousa, Paulo, additional, Blazeby, Jane M., additional, Rogers, Chris A., additional, Lim, Eric, additional, and Wordsworth, Sarah, additional

Published
2022
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