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18. Contributors

Author

Aguilar, María Rosa, primary, Alonso, Matilde, additional, Asha, Anika B., additional, Berges, C., additional, Blasco, E., additional, Cabello, José Carlos Rodríguez, additional, Carretero-González, Javier, additional, Corrales, Rocío, additional, Cui, J., additional, Custódio, Catarina A., additional, de Torre, Israel Gonzalez, additional, del Agua, Isabel, additional, del Campo, Aránzazu, additional, den Brabander, Michael, additional, Duro-Castano, A., additional, Espinosa-Cano, Eva, additional, Fischer, Hartmut R., additional, Galaev, I.Y., additional, Garcia, Santiago J., additional, García, Félix C., additional, García, José Miguel, additional, García-Arévalo, Carmen, additional, García-Fernández, Luis, additional, Gómez-Mascaraque, L.G., additional, Hao, Xiaojuan, additional, Hasirci, Nesrin, additional, Hoogenboom, Richard, additional, Jorcano, José Luis, additional, López-Manchado, Miguel Angel, additional, Malikmammadov, Elbay, additional, Malliaras, George G., additional, Mano, João F., additional, Mecerreyes, David, additional, Mikhalovsky, S.V., additional, Montero, Andrés, additional, Montero, Jorge, additional, Mora-Boza, Ana, additional, Narain, Ravin, additional, Oriol, L., additional, Palao-Suay, R., additional, Piñol, M., additional, Reglero Ruiz, José A., additional, Reis, Rui L., additional, Reyes-Ortega, Felisa, additional, Rodríguez-Escalona, G., additional, Román, Julio San, additional, Sanchez-Sanchez, Ana, additional, Sánchez-Somolinos, C., additional, Sanjuán, Ana M., additional, Savina, I.N., additional, Srinivas, Shruti, additional, Talelli, M., additional, Valencia, Leticia, additional, Vázquez, Blanca, additional, Velasco, Diego, additional, Vicent, M.J., additional, and Xiong, X., additional

Published
2019
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25. Avaliação oftalmológica de crianças de escolas públicas de Belo Horizonte/MG: um panorama acerca da baixa acuidade visual

Author

Geraldo de Barros Ribeiro, Amanda Lopes Dias Coelho, Pedro Henrique Pinheiro Chaves, Rafhael de Lima Macedo, and Thiago Augustus Blasco e Silva

Subjects
Acuidade visual, Criança, Prevalência, Refração, Saúde ocular, Ophthalmology, RE1-994
Abstract

RESUMO Objetivo: Descrever e analisar a prevalência de baixa acuidade visual e suas causas em estudantes do ensino público de Belo Horizonte/MG. Métodos: Estudo transversal de 1452 escolares de 5 a 19 anos, do ensino público de Belo Horizonte/MG, triados e atendidos entre 2011 e 2014. Resultados: Da amostra total, 150 pacientes (10,33%) apresentaram baixa acuidade visual à triagem, recebendo encaminhamento para atendimento oftalmológico. Quarenta (26,66%) foram encaminhados e compareceram à consulta, onde 29 (72,5%) apresentaram indicação de correção visual. O astigmatismo miópico simples e composto foram os diagnósticos mais relacionados à prescrição de óculos. Conclusão: O estudo mostrou que a prevalência de baixa acuidade visual na população estudada foi compatível com demais programas semelhantes. Em contrapartida, a taxa de abstenção foi maior do que o esperado, evidenciando a importância da criação de medidas preventivas e informativas quanto à importância do cuidado com a saúde ocular.

Published
2015
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31. Contributor contact details

Author

Aguilar, M.R., primary, San Román, J., additional, Hoogenboom, R., additional, Reyes-Ortega, F., additional, Cui, J., additional, del Campo, A., additional, Zrinyi, M., additional, Zelzer, M., additional, Ulijn, Rein V., additional, Peponi, L., additional, Navarro-Baena, I., additional, Kenny, J.M., additional, Samal, S.K., additional, Dash, M., additional, Dubruel, P., additional, Van Vlierberghe, S., additional, Garcia, S.J., additional, Fischer, H.R., additional, Custódio, C.A., additional, Reis, R.L., additional, Mano, J.F., additional, Talelli, M., additional, Duro-Castaño, A., additional, Rodríguez-Escalona, G., additional, Vicent, M.J., additional, Gómez-Mascaraque, L.G., additional, Palao-Suay, R., additional, Vázquez, B., additional, Savina, I.N., additional, Galaev, I.Yu., additional, Mikhalovsky, S.V., additional, Hu, J., additional, Lu, J., additional, Fabra, M.J., additional, López-Rubio, A., additional, Lagaron, J.M., additional, Blasco, E., additional, Piñol, M., additional, Oriol, L., additional, Berges, C., additional, and Sánchez-Somolinos, C., additional

Published
2014
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32. CO² filtration during pneumoperitoneum inflation and deflation in patients undergoing laparoscopy during the COVID-19 pandemic

Author

ABRAS, GUSTAVO MUNAYER, SILVA, THIAGO AUGUSTUS BLASCO E, LIMA, LUIZ FELIPE PIMENTA NOGUEIRA DE SOUZA, and LOPES, MAURO VIDIGAL DE REZENDE

Subjects
Respiração Artificial, Virologia, Cirurgia, Virology, Infecções por Coronavírus, Surgery, Coronavirus Infections, Respiration, Artificial
Abstract

The current Covid-19 pandemic has been the most discussed topic of the year, mostly about protection and ways to avoid dissemination of the virus. In the healthcare system, especially in the operating rooms, the viability of laparoscopic surgery was questioned, mostly because of the transmission through aerosol. This article tries to suggest a way to minimize risks of laparoscopic surgery, during this situation, by using electrostatic filters, a simple, effective and low cost alternative. RESUMO A atual pandemia do Covid-19 tem sido o assunto mais discutido do ano de 2020, principalmente no que se refere a proteção e as formas de limitar a disseminação do vírus. No cenário hospitalar, mais especificamente no centro cirúrgico, a viabilidade da cirurgia laparoscópica foi questionada, em relação a transmissibilidade do vírus por aerossol. Este artigo sugere uma forma de minimizar os riscos em cirurgias laparoscópicas durante esse cenário, com o uso de filtros eletrostáticos de ventilação mecânica. Uma alternativa simples, eficaz e de baixo custo.

Published
2021

33. CO² filtration during pneumoperitoneum inflation and deflation in patients undergoing laparoscopy during the COVID-19 pandemic

Author

Thiago Augustus Blasco e Silva, Luiz Felipe Pimenta Nogueira De Souza Lima, Gustavo Munayer Abras, and Mauro Vidigal De Rezende Lopes

Subjects
Inflation, Laparoscopic surgery, medicine.medical_specialty, RD1-811, Coronavirus disease 2019 (COVID-19), media_common.quotation_subject, medicine.medical_treatment, 03 medical and health sciences, 0302 clinical medicine, Pneumoperitoneum, Virology, Pandemic, medicine, Humans, In patient, Intensive care medicine, Laparoscopy, Pandemics, media_common, Infection Control, medicine.diagnostic_test, business.industry, COVID-19, Carbon Dioxide, medicine.disease, Respiration, Artificial, Deflation, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Surgery, Coronavirus Infections, business
Abstract

The current Covid-19 pandemic has been the most discussed topic of the year, mostly about protection and ways to avoid dissemination of the virus. In the healthcare system, especially in the operating rooms, the viability of laparoscopic surgery was questioned, mostly because of the transmission through aerosol. This article tries to suggest a way to minimize risks of laparoscopic surgery, during this situation, by using electrostatic filters, a simple, effective and low cost alternative.

Published
2021

34. Imidazole and imidazolium antibacterial drugs derived from amino acids

Author

Valls, A., Andreu, J.J., Falomir, E., Luis, S.V., Atrián-Blasco, E., Mitchell, S.G., and Altava, B.

Abstract

The antibacterial activity of imidazole and imidazolium salts is highly dependent upon their lipophilicity, which can be tuned through the introduction of different hydrophobic substituents on the nitrogen atoms of the imidazole or imidazolium ring of the molecule. Taking this into consideration, we have synthesized and characterized a series of imidazole and imidazolium salts derived from L-valine and L-phenylalanine containing different hydrophobic groups and tested their antibacterial activity against two model bacterial strains, Gram-negative E. coli and Gram-positive B. subtilis. Importantly, the results demonstrate that the minimum bactericidal concentration (MBC) of these derivatives can be tuned to fall close to the cytotoxicity values in eukaryotic cell lines. The MBC value of one of these compounds toward B. subtilis was found to be lower than the IC50 cytotoxicity value for the control cell line, HEK-293. Furthermore, the aggregation behavior of these compounds has been studied in pure water, in cell culture media, and in mixtures thereof, in order to determine if the compounds formed self-assembled aggregates at their bioactive concentrations with the aim of determining whether the monomeric species were in fact responsible for the observed antibacterial activity. Overall, these results indicate that imidazole and imidazolium compounds derived from L-valine and L-phenylalanine—with different alkyl lengths in the amide substitution—can serve as potent antibacterial agents with low cytotoxicity to human cell lines.

Published
2020

35. Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation

Author

Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, Generalitat de Catalunya, Ministerio de Ciencia, Innovación y Universidades (España), Giralt, Albert, Brito, Verónica, Pardo, Mónica, Rubio, S.E., Marion-Poll, Lucile, Martín-Ibáñez, Raquel, Zamora-Moratalla, Alfonsa, Bosch, Carles, Ballesteros, J.J., Blasco, E., García-Torralba, A., Pascual, Marta, Pumarola, M., Alberch, Jordi, Ginés, Silvia, Martín, E.D., Segovia, J., Soriano, E., Canals, Josep María, Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, Generalitat de Catalunya, Ministerio de Ciencia, Innovación y Universidades (España), Giralt, Albert, Brito, Verónica, Pardo, Mónica, Rubio, S.E., Marion-Poll, Lucile, Martín-Ibáñez, Raquel, Zamora-Moratalla, Alfonsa, Bosch, Carles, Ballesteros, J.J., Blasco, E., García-Torralba, A., Pascual, Marta, Pumarola, M., Alberch, Jordi, Ginés, Silvia, Martín, E.D., Segovia, J., Soriano, E., and Canals, Josep María

Abstract

Currently, molecular, electrophysiological and structural studies delineate several neural subtypes in the hippocampus. However, the precise developmental mechanisms that lead to this diversity are still unknown. Here we show that alterations in a concrete hippocampal neuronal subpopulation during development specifically affect hippocampal-dependent spatial memory. We observed that the genetic deletion of the transcription factor Helios in mice, which is specifically expressed in developing hippocampal calbindin-positive CA1 pyramidal neurons (CB-CA1-PNs), induces adult alterations affecting spatial memory. In the same mice, CA3-CA1 synaptic plasticity and spine density and morphology in adult CB-CA1-PNs were severely compromised. RNAseq experiments in developing hippocampus identified an aberrant increase on the Visinin-like protein 1 (VSNL1) expression in the hippocampi devoid of Helios. This aberrant increase on VSNL1 levels was localized in the CB-CA1-PNs. Normalization of VSNL1 levels in CB-CA1-PNs devoid of Helios rescued their spine loss in vitro. Our study identifies a novel and specific developmental molecular pathway involved in the maturation and function of a CA1 pyramidal neuronal subtype.

Published
2020

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