49 results on '"Blasco, Francesca"'
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2. Optimised method to estimate octanol water distribution coefficient (logD) in a high throughput format
3. A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis
4. Development of a FACS-based assay for evaluating antiviral potency of compound in dengue infected peripheral blood mononuclear cells
5. The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588
6. Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor
7. Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit
8. Modulation of inflammation and pathology during dengue virus infection by p38 MAPK inhibitor SB203580
9. Differences in the pharmacokinetics of currently approved antimalarial drugs in uncomplicated malaria patients compared to healthy subjects
10. NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models
11. A Cyclic Phosphoramidate Prodrug of 2′-Deoxy-2′-Fluoro-2′- C -Methylguanosine for the Treatment of Dengue Virus Infection
12. A Cyclic Phosphoramidate Prodrug of 2’-deoxy-2’-fluoro-2’-C-methylguanosine for the Treatment of Dengue Infection
13. Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors
14. Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors
15. Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation
16. Artificial Neural Network Analysis of Pharmacokinetic and Toxicity Properties of Lead Molecules for Dengue Fever, Tuberculosis and Malaria
17. Discovery of Dengue Virus NS4B Inhibitors
18. Lead Optimization of Spiropyrazolopyridones: A New and Potent Class of Dengue Virus Inhibitors
19. Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model
20. Direct inhibitors of InhA are active against Mycobacterium tuberculosis
21. Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors
22. 2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors
23. Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis
24. Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research
25. Activation of Peripheral Blood Mononuclear Cells by Dengue Virus Infection Depotentiates Balapiravir
26. Cloning, expression, purification and characterization of a novel cytochrome P450 isolated from Thermus thermophilus HB27
27. Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis
28. Discovery of the imidazo[1,5- a][1,2,4]-triazolo[1,5- d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA A α5 inverse agonist series
29. Corrigendum to “Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation” [Bioorg. Med. Chem. Lett. 23 (2013) 3741–3748]
30. Cyclic guanidines as dual 5-HT 5A/5-HT 7 receptor ligands: Structure–activity relationship elucidation
31. Cyclic guanidines as dual 5-HT 5A/5-HT 7 receptor ligands: Optimising brain penetration
32. Abstract 1922: 2-Aminothiazoles as potent and selective PI3Kalpha inhibitors: Discovery of NVP-BYL719 and structural basis for the isoform selectivity
33. A CryptosporidiumPI(4)K inhibitor is a drug candidate for cryptosporidiosis
34. Potent and Selective Inhibition of Polycythemia by the Quinoxaline JAK2 Inhibitor NVP-BSK805
35. Novel, Potent and Selective JAK2 Inhibitors.
36. Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series
37. Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Optimising brain penetration
38. Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure–activity relationship elucidation
39. Preliminary Characterization and Crystal Structure of a Thermostable Cytochrome P450 from Thermus thermophilus
40. Artificial Neural Network Analysis of Pharmacokinetic and Toxicity Properties of Lead Molecules for Dengue Fever, Tuberculosis and Malaria
41. Trifluoromethyl vs. methyl ability to direct enantioselection in microbial reduction of carbonyl substrates.
42. Complete diastereocontrol in [3+2] cycloaddition reactions: Synthesis of enantiomerically pure fluoromethyl substituted β-amino acids
43. Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model
44. Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series
45. Discovery of Dengue Virus NS4B Inhibitors.
46. Activation of Peripheral Blood Mononuclear Cells by Dengue Virus Infection Depotentiates Balapiravir.
47. Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Optimising brain penetration
48. Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure–activity relationship elucidation
49. Artificial Neural Network Analysis of Pharmacokinetic and Toxicity Properties of Lead Molecules for Dengue Fever, Tuberculosis and Malaria.
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