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11 results on '"Blank, Birgit"'

4. Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3

Author

Pigoni, Martina, Hsia, Hung‐En, Hartmann, Jana, Rudan Njavro, Jasenka, Shmueli, Merav D, Müller, Stephan A, Güner, Gökhan, Tüshaus, Johanna, Kuhn, Peer‐Hendrik, Kumar, Rohit, Gao, Pan, Tran, Mai Ly, Ramazanov, Bulat, Blank, Birgit, Hipgrave Ederveen, Agnes L, Von Blume, Julia, Mulle, Christophe, Gunnersen, Jenny M, Wuhrer, Manfred, Rammes, Gerhard, Busche, Marc Aurel, Koeglsperger, Thomas, and Lichtenthaler, Stefan F

Published
2020
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7. Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs

Author

Pacheco-Fernandez, Natalia, primary, Pakdel, Mehrshad, primary, Blank, Birgit, primary, Sanchez-Gonzalez, Ismael, primary, Weber, Kathrin, primary, Tran, Mai Ly, primary, Hecht, Tobias Karl-Heinz, primary, Gautsch, Renate, primary, Beck, Gisela, primary, Perez, Franck, primary, Hausser, Angelika, primary, Linder, Stefan, primary, and von Blume, Julia, primary

Published
2020
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8. Fam20C regulates protein secretion by Cab45 phosphorylation

Author

Hecht, Tobias Karl-Heinz, primary, Blank, Birgit, additional, Steger, Martin, additional, Lopez, Victor, additional, Beck, Gisela, additional, Ramazanov, Bulat, additional, Mann, Matthias, additional, Tagliabracci, Vincent, additional, and von Blume, Julia, additional

Published
2020
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10. Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network

Author

Crevenna, Alvaro H., primary, Blank, Birgit, additional, Maiser, Andreas, additional, Emin, Derya, additional, Prescher, Jens, additional, Beck, Gisela, additional, Kienzle, Christine, additional, Bartnik, Kira, additional, Habermann, Bianca, additional, Pakdel, Mehrshad, additional, Leonhardt, Heinrich, additional, Lamb, Don C., additional, and von Blume, Julia, additional

Published
2016
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11. Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network.

Author

Crevenna, Alvaro H., Blank, Birgit, Maiser, Andreas, Emin, Derya, Prescher, Jens, Beck, Gisela, Kienzle, Christine, Bartnik, Kira, Habermann, Bianca, Pakdel, Mehrshad, Leonhardt, Heinrich, Lamb, Don C., and von Blume, Julia

Subjects
*OLIGOMERIZATION, *CALCIUM channels, *ION channels, *MEMBRANE proteins, *BIOLOGICAL membranes
Abstract

Sorting and export of transmembrane cargoes and lysosomal hydrolases at the trans-Golgi network (TGN) are well understood. However, elucidation of the mechanism by which secretory cargoes are segregated for their release into the extracellular space remains a challenge. We have previously demonstrated that, in a reaction that requires Ca2+, the soluble TGN-resident protein Cab45 is necessary for the sorting of secretory cargoes at the TGN. Here, we report that Cab45 reversibly assembles into oligomers in the presence of Ca2+. These Cab45 oligomers specifically bind secretory proteins, such as COMP and LyzC, in a Ca2+-dependent manner in vitro. In intact cells, mutation of the Ca2+-binding sites in Cab45 impairs oligomerization, as well as COMP and LyzC sorting. Superresolution microscopy revealed that Cab45 colocalizes with secretory proteins and the TGN Ca2+ pump (SPCA1) in specific TGN microdomains. These findings reveal that Ca2+-dependent changes in Cab45 mediate sorting of specific cargo molecules at the TGN. [ABSTRACT FROM AUTHOR]

Published
2016
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