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3. Sex Differences in PrEsentation, Risk Factors, Drug and Interventional Therapies, and OUtcomes of Elderly PatientS with Pulmonary Embolism: Rationale and design of the SERIOUS-PE study

Author

Bikdeli, Behnood, Piazza, Gregory, Jimenez, David, Muriel, Alfonso, Wang, Yun, Khairani, Candrika D., Rosovsky, Rachel P., Mehdipoor, Ghazaleh, O'Donoghue, Michelle L., Spagnolo, Primavera, Dreyer, Rachel P., Bertoletti, Laurent, López-Jiménez, Luciano, Núñez, Manuel Jesús, Blanco-Molina, Ángeles, Bates, Shannon M., Gerhard-Herman, Marie, Goldhaber, Samuel Z., Monreal, Manuel, and Krumholz, Harlan M.

Published
2022
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4. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial

Author

Alcala-Diaz, Juan F, Almaden Peña, Yolanda, Aranda, Enrique, Arenas de Larriva, Antonio P, Badimon, Lina, Badimon, Juan J, Blanco-Molina, Angeles, Blanco-Rojo, Ruth, Bolivar-Muñoz, Julia, Caballero-Villarraso, Javier, Camargo, Antonio, Chica, Javier, Corina, Andreea, Criado-Garcia, Juan, Cruz-Teno, Cristina, Daponte-Codina, Antonio, de Teresa Galvan, Eduardo, Delgado-Casado, Nieves, Delgado-Lista, Javier, Estruch, Ramon, Fernandez, Juan M, Fernandez-Gandara, Carolina, Fuentes-Jimenez, Francisco, Garcia-Carpintero Fernandez-Pacheco, Sonia, Garcia-Rios, Antonio, Gomez-Delgado, Francisco, Gomez-Garduño, Angela, Gomez-Luna, Purificacion, Gomez-Luna, Maria J, Gonzalez-Guardia, Lorena, Gonzalez-Requero, Ana I., Gutierrez-Mariscal, Francisco M, Haro-Mariscal, Carmen M, Jimenez-Lucena, Rosa, Jimenez-Morales, Ana I., Leon-Acuña, Ana, Lopez-Miranda, Jose, Lopez-Segura, Fernando, Marin-Hinojosa, Carmen, Meneses Alvarez, Maria E, Mesa-Luna, Dolores, Moya-Garrido, Maria N, Muñoz-Carvajal, Ignacio, Navarro-Martos, Vanessa, Ochoa, Juan J, Ordovas, Jose M, Ortiz-Minuesa, Juan A, Ortiz-Morales, Ana M, Pan, Manuel, Peña-Orihuela, Patricia, Perez-Caballero, Ana I, Perez-Corral, Isabel, Perez-Jimenez, Francisco, Perez-Martinez, Pablo, Pi-Sunyer, Francesc X, Quintana-Navarro, Gracia M, Ramirez-Lara, Irene, Rangel-Zuñiga, Oriol A, Rodriguez-Artalejo, Fernando, Rodriguez-Cantalejo, Fernando, Romero, Miguel A, Roncero-Ramos, Irene, Ruano-Ruiz, Juan A., Ruiz de Castroviejo, Joaquin, Sanchez-Villegas, Pablo, Suarez de Lezo, Jose, Suarez de Lezo, Javier, Torres-Peña, Jose D, Vals-Delgado, Cristina, Valverde, Roberto, Visioli, Francisco, Yubero-Serrano, Elena M, Fuentes, Francisco, and Gonzalez-Requero, Ana I

Published
2022
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5. Abstract 14219: Are There Sex Differences in the Imaging Modalities and Early Use of Echocardiography in Elderly Patients With Pulmonary Embolism?

Author

Mehdipoor, Ghazaleh, Jimenez, David, Muriel, Alfonso, Piazza, Gregory, Rosovsky, Rachel, Madridano, Olga, Lopez-Saez, Juan Bosco, Mellado, Meritxell, Diaz Brasero, Ana María, OʼDonoghue, Michelle, BERTOLETTI, Laurent, Lopez-Jimenez, Luciano, Nunez-Fernandez, Manuel, Blanco-Molina, Angeles, Prince, Martin R, Gerhard-Herman, Marie, Bikdeli, Behnood, Krumholz, Harlan M, and Monreal, Manuel

Published
2022
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6. Abstract 13807: Sex Differences in Patients Characteristics, Risk Factors, and Symptomatology in Older Adults With Pulmonary Embolism: Findings From the SERIOUS-PE Study

Author

Bikdeli, Behnood, Jimenez, David, Piazza, Gregory, Muriel, Alfonso, wang, yun, Khairani, Candrika D, Rosovsky, Rachel, Madridano, Olga, Lopez-Saez, Juan Bosco, Mellado, Meritxell, Diaz Brasero, Ana María, Mehdipoor, Ghazaleh, OʼDonoghue, Michelle, Spagnolo, Primavera A, Lu, Yuan, BERTOLETTI, Laurent, Lopez-Jimenez, Luciano, Nunez-Fernandez, Manuel J, Blanco-Molina, Angeles, Bates, Shannon, Gerhard-Herman, Marie, Goldhaber, Samuel, Monreal, Manuel, and Krumholz, Harlan M

Published
2022
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9. Quantitative evaluation of capillaroscopic microvascular changes in patients with established coronary heart disease

Author

Sanchez-Garcia, M. Esther, Ramirez-Lara, Irene, Gomez-Delgado, Francisco, Yubero-Serrano, Elena M., Leon-Acuña, Ana, Marin, Carmen, Alcala-Diaz, Juan F., Camargo, Antonio, Lopez-Moreno, Javier, Perez-Martinez, Pablo, Tinahones, Francisco José, Ordovas, Jose M., Caballero, Javier, Blanco-Molina, Angeles, Lopez-Miranda, Jose, and Delgado-Lista, Javier

Published
2018
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10. Evaluación cuantitativa de los cambios microvasculares capilaroscópicos en pacientes con cardiopatía isquémica establecida

Author

Sanchez-Garcia, M. Esther, Ramirez-Lara, Irene, Gomez-Delgado, Francisco, Yubero-Serrano, Elena M., Leon-Acuña, Ana, Marin, Carmen, Alcala-Diaz, Juan F., Camargo, Antonio, Lopez-Moreno, Javier, Perez-Martinez, Pablo, Tinahones, Francisco José, Ordovas, Jose M., Caballero, Javier, Blanco-Molina, Angeles, Lopez-Miranda, Jose, and Delgado-Lista, Javier

Published
2018
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15. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial

Author

Delgado-Lista, Javier, primary, Alcala-Diaz, Juan F, additional, Torres-Peña, Jose D, additional, Quintana-Navarro, Gracia M, additional, Fuentes, Francisco, additional, Garcia-Rios, Antonio, additional, Ortiz-Morales, Ana M, additional, Gonzalez-Requero, Ana I, additional, Perez-Caballero, Ana I, additional, Yubero-Serrano, Elena M, additional, Rangel-Zuñiga, Oriol A, additional, Camargo, Antonio, additional, Rodriguez-Cantalejo, Fernando, additional, Lopez-Segura, Fernando, additional, Badimon, Lina, additional, Ordovas, Jose M, additional, Perez-Jimenez, Francisco, additional, Perez-Martinez, Pablo, additional, Lopez-Miranda, Jose, additional, Almaden Peña, Yolanda, additional, Aranda, Enrique, additional, Arenas de Larriva, Antonio P, additional, Badimon, Juan J, additional, Blanco-Molina, Angeles, additional, Blanco-Rojo, Ruth, additional, Bolivar-Muñoz, Julia, additional, Caballero-Villarraso, Javier, additional, Chica, Javier, additional, Corina, Andreea, additional, Criado-Garcia, Juan, additional, Cruz-Teno, Cristina, additional, Daponte-Codina, Antonio, additional, de Teresa Galvan, Eduardo, additional, Delgado-Casado, Nieves, additional, Delgado-Lista, Javier, additional, Estruch, Ramon, additional, Fernandez, Juan M, additional, Fernandez-Gandara, Carolina, additional, Fuentes-Jimenez, Francisco, additional, Garcia-Carpintero Fernandez-Pacheco, Sonia, additional, Gomez-Delgado, Francisco, additional, Gomez-Garduño, Angela, additional, Gomez-Luna, Purificacion, additional, Gomez-Luna, Maria J, additional, Gonzalez-Guardia, Lorena, additional, Gonzalez-Requero, Ana I., additional, Gutierrez-Mariscal, Francisco M, additional, Haro-Mariscal, Carmen M, additional, Jimenez-Lucena, Rosa, additional, Jimenez-Morales, Ana I., additional, Leon-Acuña, Ana, additional, Marin-Hinojosa, Carmen, additional, Meneses Alvarez, Maria E, additional, Mesa-Luna, Dolores, additional, Moya-Garrido, Maria N, additional, Muñoz-Carvajal, Ignacio, additional, Navarro-Martos, Vanessa, additional, Ochoa, Juan J, additional, Ortiz-Minuesa, Juan A, additional, Pan, Manuel, additional, Peña-Orihuela, Patricia, additional, Perez-Corral, Isabel, additional, Pi-Sunyer, Francesc X, additional, Ramirez-Lara, Irene, additional, Rodriguez-Artalejo, Fernando, additional, Romero, Miguel A, additional, Roncero-Ramos, Irene, additional, Ruano-Ruiz, Juan A., additional, Ruiz de Castroviejo, Joaquin, additional, Sanchez-Villegas, Pablo, additional, Suarez de Lezo, Jose, additional, Suarez de Lezo, Javier, additional, Vals-Delgado, Cristina, additional, Valverde, Roberto, additional, and Visioli, Francisco, additional

Published
2022
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16. PICO Questions and DELPHI Methodology for the Management of Venous Thromboembolism Associated with COVID-19

Author

Riera-Mestre, Antoni, Jara-Palomares, Luis, Lecumberri, Ramón, Trujillo-Santos, Javier, Grau, Enric, Blanco-Molina, Angeles, Carbonell, Ana Piera, Jiménez, Sonia, Vargas, Manuel Frías, Fuset, Mari, Bellmunt-Montoya, Sergi, Monreal, Manuel, Jiménez, David, Project, on behalf of the COVILAX, Institut Català de la Salut, [Riera-Mestre A] Internal Medicine Department, Hospital Universitari de Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain. [Jara-Palomares L] Medical-Surgical Unit for Respiratory Diseases, Virgen del Rocío University Hospital, Sevilla, Spain. Center for Biomedical Research in Respiratory Diseases Network (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. [Lecumberri R] Hematology Department, Clínica Universidad de Navarra, Pamplona, Spain. Center for Biomedical Research Network on Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain. [Trujillo-Santos J] Internal Medicine Department, Hospital General Universitario Santa Lucía, Cartagena, Spain. Faculty of Health Sciences, Universidad Católica San Antonio de Murcia (UCAM), Murcia, Spain. [Grau E] Hematology Department, Lluis Alcanyis de Xativa Hospital, Valencia, Spain. [Blanco-Molina A] Internal Medicine Unit, Hospital Universitario Reina Sofía, Córdoba, Spain. [Bellmunt-Montoya S] Servei de Angiologia, Cirurgia Vascular i Endovascular, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Cirurgia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
pulmonary embolism, Delphi Technique, Coronaviruses, Deep vein, Delphi method, coronavirus, law.invention, law, virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Medicine, Trombosi, enfermedades cardiovasculares::enfermedades vasculares::embolia y trombosis::tromboembolia::tromboembolia venosa [ENFERMEDADES], anticoagulation, COVID-19 (Malaltia) - Complicacions, Embòlia pulmonar, Cardiovascular Diseases::Vascular Diseases::Embolism and Thrombosis::Thromboembolism::Venous Thromboembolism [DISEASES], Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], Venous Thromboembolism, Medicina clínica - Presa de decisions, Intensive care unit, Thrombosis, QR1-502, Pulmonary embolism, Ciencias de la información::análisis de sistemas::técnica Delfos [CIENCIA DE LA INFORMACIÓN], Infectious Diseases, medicine.anatomical_structure, Information Science::Systems Analysis::Delphi Technique [INFORMATION SCIENCE], medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), medicine.drug_class, Low molecular weight heparin, Microbiology, Article, deep vein thrombosis, Virology, Humans, Intensive care medicine, Tromboembolisme, Duration of Therapy, business.industry, fungi, Anticoagulants, COVID-19, Heparin, Low-Molecular-Weight, medicine.disease, Coronavirus, Embolism, business, venous thromboembolic disease
Abstract

Patients with coronavirus disease 2019 (COVID-19) have a higher risk of venous thromboembolic disease (VTE) than patients with other infectious or inflammatory diseases, both as macrothrombosis (pulmonar embolism and deep vein thrombosis) or microthrombosis. However, the use of anticoagulation in this scenario remains controversial. This is a project that used DELPHI methodology to answer PICO questions related to anticoagulation in patients with COVID-19. The objective was to reach a consensus among multidisciplinary VTE experts providing answers to those PICO questions. Seven PICO questions regarding patients with COVID-19 responded with a broad consensus: 1. It is recommended to avoid pharmacological thromboprophylaxis in most COVID-19 patients not requiring hospital admission, 2. In most hospitalized patients for COVID-19 who are receiving oral anticoagulants before admission, it is recommended to replace them by low molecular weight heparin (LMWH) at therapeutic doses, 3. Thromboprophylaxis with LMWH at standard doses is suggested for COVID-19 patients admitted to a conventional hospital ward, 4. Standard-doses thromboprophylaxis with LMWH is recommended for COVID-19 patients requiring admission to Intensive Care Unit, 5. It is recommended not to determine D-Dimer levels routinely in COVID-19 hospitalized patients to select those in whom VTE should be suspected, or as a part of the diagnostic algorithm to rule out or confirm a VTE event, 6. It is recommended to discontinue pharmacological thromboprophylaxis at discharge in most patients hospitalized for COVID-19, 7. It is recommended to withdraw anticoagulant treatment after 3 months in most patients with a VTE event associated with COVID-19. The combination of PICO questions and DELPHI methodology provides a consensus on different recommendations for anticoagulation management in patients with COVID-19.

Published
2021
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19. Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years

Author

Jara-Palomares, Luis, Alfonso, Maria, Maestre, Ana, Jimenez, David, Garcia-Bragado, Fernando, Font, Carme, Lopez Reyes, Raquel, Hernandez Blasco, Luis, Vidal, Gemma, Otero, Remedios, Monreal, Manuel, Adarraga, Ma Dolores, Angel Aibar, Miguel, Aibar, Jesus, Amado, Cristina, Ignacio Arcelus, Juan, Ballaz, Aitor, Barba, Raquel, Barron, Manuel, Barron-Andres, Belen, Bascunana, Jose, Blanco-Molina, Angeles, Maria Camon, Ana, Canas, Inmaculada, Carrasco, Cristina, Castro, Joaquin, de Ancos, Cristina, Del Toro, Jorge, Demelo, Pablo, Antonio Diaz-Peromingo, Jose, Diaz-Simon, Raquel, Falga, Conxita, Isabel Farfan, Ana, Fernandez-Capitan, Carmen, Del Carmen Fernandez-Criado, Maria, Fernandez-Nunez, Sandra, Fidalgo, Angeles, Font, Llorenc, Angelina Garcia, Maria, Garcia-Morillo, Marcial, Garcia-Raso, Aranzzu, Gavin-Sebastian, Olga, del Carmen Gayol, Maria, Gil-Diaz, Aida, Gomez, Vicente, Gomez-Cuervo, Covadonga, Gonzalez-Martinez, Jose, Grau, Enric, Gutierrez, Javier, Gutierrez-Gonzalez, Sara, Iglesias, Marina, Jaras, Ma Jesus, Jou, Ines, Dolores Joya, Maria, Lalueza, Antonio, Lima, Jorge, Llamas, Pilar, Luis Lobo, Jose, Lopez-Jimenez, Luciano, Lopez-Miguel, Patricia, Jose Lopez-Nunez, Juan, Bosco Lopez-Saez, Juan, Alejandro Lorente, Manuel, Lorenzo, Alicia, Loring, Monica, Madridano, Olga, Javier Marchena, Pablo, Miguel Martin, Javier, Mellado, Meritxell, del Valle Morales, Ma, Luisa Nieto, Maria, Antonio Nieto, Jose, Jesus Nunez, Manuel, Carmen Olivares, Maria, Maria Pedrajas, Jose, Pellejero, Galadriel, Prez-Rus, Gloria, Peris, Ma Luisa, Antonio Porras, Jose, Rivas, Agustina, Angeles Rodriguez-Davila, Ma, Adela Rodriguez-Hernandez, A, Rubio, Carmen Ma, Ruiz-Artacho, Pedro, Ruiz-Ruiz, Justo, Ruiz-Sada, Pablo, Carles Sahuquillo, Joan, Salazar, Vladimir, Samperiz, Angel, Sanchez Munoz-Torrero, Juan Francisco, Sancho, Teresa, Soler, Silvia, Maria Surinach, Jose, Tapia, Elena, Tolosa, Caries, Isabel Torres, Maria, Trujillo-Santos, Javier, Uresandi, Fernando, Valle, Reina, Villares, Paula, Gutierrez, Paula, Javier Vazquez, Fernando, Vilaseca, Alicia, Vanassche, Thomas, Vandenbriele, Christophe, Verhamme, Peter, Hirmerova, Jana, Maly, Radovan, Celis, Gregory, del Pozo, Gustavo, Salgado, Estuardo, Benzidia, Ilham, Bertoletti, Laurent, Bura-Riviere, Alessandra, Debourdeau, Philippe, Farge-Bancel, Dominique, Hij, Adrian, Mahe, Isabelle, Moustafa, Fares, Schellong, Sebastian, Braester, Andrei, Brenner, Benjamin, Tzoran, Inna, Sharif-Kashani, Babak, Barillari, Giovanni, Bilora, Franca, Bortoluzzi, Cristiano, Brandolin, Barbara, Bucherini, Eugenio, Ciammaichella, Maurizio, Dentali, Francesco, Di Micco, Pierpaolo, Maida, Rosa, Mastroiacovo, Daniela, Mumoli, Nicola, Pace, Federica, Parisi, Roberto, Pesavento, Raffaelle, Prandoni, Paolo, Quintavalla, Roberto, Rocci, Anna, Romualdi, Roberta, Sinicalchi, Carmine, Tufano, Antonella, Visona, Adriana, Hong, Ngoc Vo, Zalunardo, Beniamino, Gibietis, Valdis, Kigitovica, Dana, Skride, Andris, Bosevski, Marijan, Bounameaux, Henri, Mazzolai, Lucia, Caprini, Joseph A, Hanh, My Bui, Khanh, Quoc Pham, Reis, Abilio, UCH. Departamento de Medicina (Extinguido), Producción Científica UCH 2019, UCH. Departamento de Medicina y Cirugía, Sanofi España, Bayer, Sociedad Española de Neumología y Cirugía Torácica, Jara-Palomares, L., Alfonso, M., Maestre, A., Jimenez, D., Garcia-Bragado, F., Font, C., Reyes, R. L., Blasco, L. H., Vidal, G., Otero, R., Monreal, M., Adarraga, M. ªD., Aibar, M. A., Aibar, J., Amado, C., Arcelus, J. I., Ballaz, A., Barba, R., Barron, M., Barron-Andres, B., Bascunana, J., Blanco-Molina, A., Camon, A. M., Canas, I., Carrasco, C., Castro, J., de Ancos, C., Del Toro, J., Demelo, P., Diaz-Peromingo, J. A., Diaz-Simon, R., Falga, C., Farfan, A. I., Fernandez-Capitan, C., del Carmen Fernandez-Criado, M., Fernandez-Nunez, S., Fidalgo, A., Font, L., Garcia, M. A., Garcia-Morillo, M., Garcia-Raso, A., Gavin-Sebastian, O., del Carmen Gayol, M., Gil-Diaz, A., Gomez, V., Gomez-Cuervo, C., Gonzalez-Martinez, J., Grau, E., Gutierrez, J., Gutierrez-Gonzalez, S., Iglesias, M., Jaras, M. ªJ., Jou, I., Joya, M. D., Lalueza, A., Lima, J., Llamas, P., Lobo, J. L., Lopez-Jimenez, L., Lopez-Miguel, P., Lopez-Nunez, J. J., Lopez-Saez, J. B., Lorente, M. A., Lorenzo, A., Loring, M., Madridano, O., Marchena, P. J., Martin, J. M., Mellado, M., Morales, M. ªV., Nieto, M. L., Nieto, J. A., Nunez, M. J., Olivares, M. C., Pedrajas, J. M., Pellejero, G., Perez-Rus, G., Peris, M. ªL., Porras, J. A., Rivas, A., Rodriguez-Davila, M. ªA., Adela Rodriguez-Hernandez, A., Rubio, C. M., Ruiz-Artacho, P., Ruiz-Ruiz, J., Ruiz-Sada, P., Sahuquillo, J. C., Salazar, V., Samperiz, A., Munoz-Torrero, J. F. S., Sancho, T., Soler, S., Surinach, J. M., Tapia, E., Tolosa, C., Torres, M. I., Trujillo-Santos, J., Uresandi, F., Valle, R., Villares, P., Gutierrez, P., Vazquez, F. J., Vilaseca, A., Vanassche, T., Vandenbriele, C., Verhamme, P., Hirmerova, J., Maly, R., Celis, G., del Pozo, G., Salgado, E., Benzidia, I., Bertoletti, L., Bura-Riviere, A., Debourdeau, P., Farge-Bancel, D., Hij, A., Mahe, I., Moustafa, F., Schellong, S., Braester, A., Brenner, B., Tzoran, I., Sharif-Kashani, B., Barillari, G., Bilora, F., Bortoluzzi, C., Brandolin, B., Bucherini, E., Ciammaichella, M., Dentali, F., Di Micco, P., Maida, R., Mastroiacovo, D., Mumoli, N., Pace, F., Parisi, R., Pesavento, R., Prandoni, P., Quintavalla, R., Rocci, A., Romualdi, R., Sinicalchi, C., Tufano, A., Visona, A., Hong, N. V., Zalunardo, B., Gibietis, V., Kigitovica, D., Skride, A., Bosevski, M., Bounameaux, H., Mazzolai, L., Caprini, J. A., Bui, H. M., Pham, K. Q., and Reis, A.

Subjects
PREDICTION, Embolism, Aparato circulatorio - Enfermedades - Pronóstico, Cardiovascular system - Diseases - Prognosis, lcsh:Medicine, 030204 cardiovascular system & hematology, 0302 clinical medicine, Retrospective Studie, Risk Factors, 030212 general & internal medicine, lcsh:Science, INDEX, education.field_of_study, Multidisciplinary, Middle Aged, Prognosis, Predictive value, Pulmonary embolism, Multidisciplinary Sciences, DERIVATION, Science & Technology - Other Topics, Major bleeding, Human, medicine.medical_specialty, ANTITHROMBOTIC THERAPY, Disease-free survival, Prognosi, Population, DIAGNOSIS, VALIDATION, Article, 03 medical and health sciences, STRATIFICATION, Thromboembolism, Internal medicine, medicine, Humans, In patient, education, Retrospective Studies, OLDER, VENOUS THROMBOEMBOLISM, Science & Technology, business.industry, Risk Factor, lcsh:R, CLINICAL PRESENTATION, Retrospective cohort study, medicine.disease, Embolia pulmonar - Pronóstico, Shock index, Pulmonary embolism - Prognosis, Spain, lcsh:Q, business, Pulmonary Embolism
Abstract

The RIETE investigators., In young patients with acute pulmonary embolism (PE), the predictive value of currently available prognostic tools has not been evaluated. Our objective was to compare prognostic value of 7 available tools (GPS, PESI, sPESI, Prognostic Algorithm, PREP, shock index and RIETE) in patients aged, This study received funding: SEPAR (1/2016) grupo GeCIR. We express our gratitude to Sanofi Spain for supporting this Registry with an unrestricted educational grant. We also wish to thank Bayer Pharma AG for supporting this Registry. Bayer Pharma AG’s support was limited to the part of RIETE outside Spain, which accounts for a 25.20% of the total patients included in the RIETE Registry.

Published
2019

21. Prediction of early mortality in patients with cancer-associated thrombosis in the rIete Database

Author

Fuentes, Harry E., Tafur, Alfonso J., Caprini, Joseph A., Alatri, Adriano, Trujillo-santos, Javier, Farge-bancel, Dominique, Rosa, Vladimir, Font, Llorenc, Vilaseca, Alicia, Monreal, Manuel, Adarraga, Maria D., Aibar, Miguel A., Aibar, Jesus, Amado, Cristina, Aranda, Carlos, Arcelus Juan, I, Ballaz, Aitor, Barba, Raquel, Barillari, Giovanni, Barron, Manuel, Barron-Andres, Belen, Bascunana, Jose, Benzidia, Ilham, Bertoletti, Laurent, Blanco-Molina, Angeles, Bilora, Franca, Bortoluzzi, Cristiano, Bosevski, Marijan, Bounameaux, Henri, Braester, Andrei, Brandolin, Barbara, Brenner, Benjamin, Bucherini, Eugenio, Hanh My Bui, Bura-Riviere, Alessandra, Camon, Ana M., Carrasco, Cristina, Castro, Joaquin, Cesta, Alisia, Ciammaichella, Maurizio, Cruz, Javier A., de Ancos, Cristina, del Toro, Jorge, Demelo, Pablo, Dentali, Francesco, del Carmen Diaz-pedroche, Maria, Diaz-Peromingo, Jose A., Di Micco, Pierpaolo, Di Pangrazio, Marco, Ellis, Martin, Encabo, Marta, Falga, Conxita, Falvo, Nicolas, Farfan Ana, Fernandez-Capitan, Carmen, Angeles Fidalgo, Maria, Font, Carme, Fresa, Marco, Furest, Ildefonso, Garcia, Maria A., Garcia-Braoado, Ferran, Garcia-Morillo, Marcia, Garcia-Raso, Aranzazu, Gavin, Olga, Gil-Diaz, Aida, Gomez, Vicente, Gomez-Cuervo, Covadonga, Gonzalez-Martinez, Jose, Grandone, Elvira, Grau, Enric, Guijarro, Ricardo, Gutierrez, Javier, Gutierrez, Paula, Hernandez-Blasco, Luis, Hu, Adrian, Hirmerova, Jana, Imbalzano, Egidio, Jara-Palomares, Luis, Jaras, Maria J., Jimenez, David, Jou, Ines, Joya, Maria D., Krstevski, Gorjan, Lessiani, Gianfranco, Lima, Jorge, Llamas, Pilar, Lobo, Jose L., Lopez-Jimenez, Luciano, Lopez-Miguel, Patricia, Lopez-Nunez, Juan J., Lopez-Reyes, Raquel, Lopez-Saez, Juan B., Lorente, Manuel A., Lorenzo, Alicia, Loring, Monica, Lumbierres, Marina, Mahe, Isabelle, Maida, Rosa, Maly, Radovan, Manrique-Abos, Isabel, Marchena, Pablo J., Martin-Fernandez, Miguel, Martin-Guerra, Javier M., Martin-Romero, Miguel, Mastroiacovo, Danicla, Mazzolai, Lucia, Mellado, Meritxell, Merah, Adel, del Valle Morales, Maria, Moustafa, Fares, Ney, Barbara, Nieto, Jose A., Nunez, Manuel J., del Carmen Olivares, Maria, Otalora, Sonia, Otero, Remedios, Pace, Federica, Parisi, Roberto, Pedrajas, Jose Maria, Pellejero, Galadriel, Perez-Ductor, Cristina, Perez-Jacoiste, Asuncion, Perez-Rus, Gloria, Peris, Maria L., Pesavento, Raffaele, Pesce, Maria L., Porras, Jose A., Prandoni, Paolo, Quinta-Valla, Roberto, Riesco, David, Rivas, Agustina, Rocci, Anna, Rodriguez-Davila, Maria A., Rodriguez-Hernandez, Adela, Rubio, Carmen M., Ruiz-Alcaraz, Sandra, Ruiz-Artacho, Pedro, Ruiz-Ruiz, Justo, Ruiz-Sada, Pablo, Ruiz-Torregrosa, Paloma, Sahuquillo, Joan C., Sala-Sainz, Carmen, Salgado, Estuardo, Samperiz, Angel, Sanchez-Munoz-Torrero, Juan F., Sancho, Teresa, Sanoja, Indra D., Siniscalchi, Carmine, Skride, Andris, Soler, Silvia, Sotgiu, Pietro, Soto, Maria J., Surinach, Jose M., Tiraferri, Eros, Tonello, Diego, Torres Maria, Tufano, Antonella, Tzoran, Inns, Uresandi, Fernando, Usandizaga, Esther, Valle, Reins, Vanassche, Thomas, Vandenbriele, Christophe, Vazquez, Fernando J., Verhamme, Peter, Villalobos, Aurora, Visona, Adriana, Ngoc Vo Hong, Yoo, Hugo H., Zdraveska, Marija, Fuentes, Harry E., Tafur, Alfonso J., Caprini, Joseph A., Alatri, Adriano, Trujillo-santos, Javier, Farge-bancel, Dominique, Rosa, Vladimir, Font, Llorenc, Vilaseca, Alicia, Monreal, Manuel, Adarraga, Maria D., Aibar, Miguel A., Aibar, Jesu, Amado, Cristina, Aranda, Carlo, Arcelus, Juan, I, Ballaz, Aitor, Barba, Raquel, Barillari, Giovanni, Barron, Manuel, Barron-Andres, Belen, Bascunana, Jose, Benzidia, Ilham, Bertoletti, Laurent, Blanco-Molina, Angele, Bilora, Franca, Bortoluzzi, Cristiano, Bosevski, Marijan, Bounameaux, Henri, Braester, Andrei, Brandolin, Barbara, Brenner, Benjamin, Bucherini, Eugenio, Hanh My, Bui, Bura-Riviere, Alessandra, Camon, Ana M., Carrasco, Cristina, Castro, Joaquin, Cesta, Alisia, Ciammaichella, Maurizio, Cruz, Javier A., de Ancos, Cristina, del Toro, Jorge, Demelo, Pablo, Dentali, Francesco, del Carmen Diaz-pedroche, Maria, Diaz-Peromingo, Jose A., Di Micco, Pierpaolo, Di Pangrazio, Marco, Ellis, Martin, Encabo, Marta, Falga, Conxita, Falvo, Nicola, Farfan, Ana, Fernandez-Capitan, Carmen, Angeles Fidalgo, Maria, Font, Carme, Fresa, Marco, Furest, Ildefonso, Garcia, Maria A., Garcia-Braoado, Ferran, Garcia-Morillo, Marcia, Garcia-Raso, Aranzazu, Gavin, Olga, Gil-Diaz, Aida, Gomez, Vicente, Gomez-Cuervo, Covadonga, Gonzalez-Martinez, Jose, Grandone, Elvira, Grau, Enric, Guijarro, Ricardo, Gutierrez, Javier, Gutierrez, Paula, Hernandez-Blasco, Lui, Hu, Adrian, Hirmerova, Jana, Imbalzano, Egidio, Jara-Palomares, Lui, Jaras, Maria J., Jimenez, David, Jou, Ine, Joya, Maria D., Krstevski, Gorjan, Lessiani, Gianfranco, Lima, Jorge, Llamas, Pilar, Lobo, Jose L., Lopez-Jimenez, Luciano, Lopez-Miguel, Patricia, Lopez-Nunez, Juan J., Lopez-Reyes, Raquel, Lopez-Saez, Juan B., Lorente, Manuel A., Lorenzo, Alicia, Loring, Monica, Lumbierres, Marina, Mahe, Isabelle, Maida, Rosa, Maly, Radovan, Manrique-Abos, Isabel, Marchena, Pablo J., Martin-Fernandez, Miguel, Martin-Guerra, Javier M., Martin-Romero, Miguel, Mastroiacovo, Danicla, Mazzolai, Lucia, Mellado, Meritxell, Merah, Adel, del Valle Morales, Maria, Moustafa, Fare, Ney, Barbara, Nieto, Jose A., Nunez, Manuel J., del Carmen Olivares, Maria, Otalora, Sonia, Otero, Remedio, Pace, Federica, Parisi, Roberto, Pedrajas, Jose Maria, Pellejero, Galadriel, Perez-Ductor, Cristina, Perez-Jacoiste, Asuncion, Perez-Rus, Gloria, Peris, Maria L., Pesavento, Raffaele, Pesce, Maria L., Porras, Jose A., Prandoni, Paolo, Quinta-Valla, Roberto, Riesco, David, Rivas, Agustina, Rocci, Anna, Rodriguez-Davila, Maria A., Rodriguez-Hernandez, Adela, Rubio, Carmen M., Ruiz-Alcaraz, Sandra, Ruiz-Artacho, Pedro, Ruiz-Ruiz, Justo, Ruiz-Sada, Pablo, Ruiz-Torregrosa, Paloma, Sahuquillo, Joan C., Sala-Sainz, Carmen, Salgado, Estuardo, Samperiz, Angel, Sanchez-Munoz-Torrero, Juan F., Sancho, Teresa, Sanoja, Indra D., Siniscalchi, Carmine, Skride, Andri, Soler, Silvia, Sotgiu, Pietro, Soto, Maria J., Surinach, Jose M., Tiraferri, Ero, Tonello, Diego, Torres, Maria, Tufano, Antonella, Tzoran, Inn, Uresandi, Fernando, Usandizaga, Esther, Valle, Rein, Vanassche, Thoma, Vandenbriele, Christophe, Vazquez, Fernando J., Verhamme, Peter, Villalobos, Aurora, Visona, Adriana, Ngoc Vo, Hong, Yoo, Hugo H., and Zdraveska, Marija

Subjects
Adult, Male, Internationality, Adolescent, Population, 030204 cardiovascular system & hematology, 030230 surgery, computer.software_genre, Logistic regression, Risk Assessment, Cohort Studies, Young Adult, 03 medical and health sciences, Mortality, Neoplasms, Premature, Thrombosis, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Humans, Medicine, Registries, Child, education, Aged, education.field_of_study, Framingham Risk Score, Database, business.industry, Infant, Newborn, Infant, Venous Thromboembolism, Odds ratio, Middle Aged, medicine.disease, Pulmonary embolism, Logistic Models, Child, Preschool, Predictive value of tests, Multivariate Analysis, Female, Cardiology and Cardiovascular Medicine, Risk assessment, business, computer, Cohort study
Abstract

BACKGROUND: Proper risk stratification of patients for early mortality after cancer-associated thrombosis may lead to personalized anticoagulation protocols. Therefore, we aimed to derive and validate a scoring system to predict early mortality in this population. To this end, we selected patients with active cancer and thrombosis from the Computerized Registry of Patients with Venous Thromboembolism database. METHODS: The main outcome was all cause mortality within the month following a thrombotic event. We used a simple random selection to split are data in a derivation and a validation cohort. In the derivation cohort, we used recursive partitioning and binary logistic regression to identify groups at risk and to determine the likelihood of the primary outcome. The risk score was developed based on odds ratios from the final multivariate model, and then tested in the validation cohort. RESULTS: In 10,025 eligible patients, we identified 6 predictors of 30-day mortality: leukocytosis =11.5x109/L; platelet count =160x109/L, metastasis, recent immobility, initial presentation as pulmonary embolism and Body Mass Index

Published
2019

22. Venous thromboembolism in women using hormonal contraceptives. Findings from the RIETE Registry

Author

Blanco-Molina, Angeles, Trujillo-Santos, Javier, Tirado, Raimundo, Cañas, Inmaculada, Riera, Antoni, Valdés, Mariano, Monreal, Manuel, Renseigné, Non, and Mismetti, Patrick

Subjects
[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, cardiovascular diseases
Abstract

There is scarce information on the clinical characteristics of contraceptive users who develop venous thromboembolism (VTE). RIETE is an ongoing registry of consecutive patients with symptomatic, objectively confirmed, acute VTE. We analyzed the clinical characteristics and additional risk factors for VTE in all enrolled women aged /=4 days, 44 (7.4%) were postoperative. The most common reason for immobility was lower limb trauma not requiring surgery; 25% of users with recent immobility had received thromboprophylaxis. The most common type of surgery was non-major orthopaedic surgery. Twenty-one (48%) users with postoperative VTE had received prophylaxis. The percentage of users and non-users who tested positive for thrombophilia was similar. Contraceptive use remains the most frequent risk factor for VTE in women at fertile age. Identifying those at increased risk for VTE seems to be difficult. In the meanwhile, a higher use of thromboprophylaxis during immobility or minor surgery should be warranted.

Published
2009

24. Effects of different dietary cholesterol concentrations on lipoprotein plasma concentrations and on cholesterol efflux from Fu5AH cells

Author

Blanco-Molina, Angeles, primary, Castro, Graciela, additional, Martín-Escalante, Dolores, additional, Bravo, Dolores, additional, JoséLópez-Miranda, José, additional, Castro, Pedro, additional, López-Segura, Fernando, additional, Fruchart, Jean C, additional, Ordová, JoséM, additional, and Pérez-Jiménez, Francisco, additional

Published
1998
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28. Fever and deep venous thrombosis. Findings from the RIETE registry.

Author

Barba R, Di Micco P, Blanco-Molina A, Delgado C, Cisneros E, Villalta J, Morales MV, Bura-Riviere A, Debourdeau P, and Monreal M

Subjects
Acute Disease, Adult, Aged, Aged, 80 and over, Female, Fever etiology, Hemorrhage etiology, Humans, Male, Middle Aged, Pulmonary Embolism etiology, Pulmonary Embolism mortality, Time Factors, Venous Thrombosis complications, Fever mortality, Hemorrhage mortality, Registries, Venous Thrombosis mortality
Abstract

Fever is a presenting sign in some patients with acute deep venous thrombosis (DVT), but its influence on outcome has not been thoroughly investigated. RIETE is an ongoing, international, observational registry of consecutive patients with symptomatic, objectively confirmed, acute venous thromboembolism. The aim of the present study was to assess the prevalence of fever in patients with acute DVT, and to compare their outcome during the first month of therapy, according to the presence or absence of fever. As of September 2009, 14,480 patients with symptomatic DVT have been enrolled in RIETE. Of these, 707 (4.9%) had fever at presentation. During the 30-day study period, 448 patients (3.1%) died, 171 (1.2%) developed DVT recurrences, 376 (2.6%) had pulmonary embolism, and 384 (2.6%) had a major bleeding. Patients initially presenting with fever had a higher mortality (5.8% vs. 2.9%; odds ratio: 2.6; 95% CI 1.9-3.5) than those without fever. Among the causes of death, pulmonary embolism (0.7% vs. 0.1%) and infection (1.1% vs. 0.3%) were significantly more common in patients presenting with fever. Multivariate analysis confirmed that DVT patients with fever had an increased mortality (hazard ratio: 2.00; 95% CI 1.44-2.77) irrespectively of the patient's age, body weight, and risk factors for VTE. Fever is not uncommon in patients with DVT, and carries a worse outcome.

Published
2011
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29. Venous thromboembolism in women taking hormonal contraceptives.

Author

Blanco-Molina A and Monreal M

Subjects
Contraceptives, Oral, Combined adverse effects, Contraceptives, Oral, Hormonal therapeutic use, Estrogens administration & dosage, Estrogens adverse effects, Female, Humans, Immobilization adverse effects, Incidence, Levonorgestrel adverse effects, Mass Screening economics, Pulmonary Embolism chemically induced, Pulmonary Embolism epidemiology, Pulmonary Embolism mortality, Risk Assessment, Thrombophilia diagnosis, Venous Thromboembolism chemically induced, Contraceptives, Oral, Hormonal adverse effects, Venous Thromboembolism epidemiology
Abstract

Hormonal contraceptives are a popular method of contraception, but their use has been associated with an increased risk for venous thromboembolism. In order to reduce such risk, these compounds have been changed in their dosage, chemical composition and route of administration. The absolute risk of death from pulmonary embolism in contraceptive users has been estimated to be 10.5 (95% CI: 6.2-16.6) per million woman-years. The safest option is an oral contraceptive containing levonorgestrel combined with a low dose of estrogen. Identifying women at increased risk for venous thromboembolism is difficult, and greater use of thromboprophylaxis during immobility or minor surgery should be warranted. Several authors have called for all women to be screened for thrombophilia before prescription of hormonal contraceptives, but its cost-effectiveness remains uncertain.

Published
2010
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30. Venous thromboembolism in women using hormonal contraceptives. Findings from the RIETE Registry.

Author

Blanco-Molina A, Trujillo-Santos J, Tirado R, Cañas I, Riera A, Valdés M, and Monreal M

Subjects
Adult, Female, Humans, Middle Aged, Pregnancy, Risk Factors, Thrombophilia diagnosis, Venous Thromboembolism prevention & control, Young Adult, Contraceptives, Oral, Hormonal adverse effects, Venous Thromboembolism etiology
Abstract

There is scarce information on the clinical characteristics of contraceptive users who develop venous thromboembolism (VTE). RIETE is an ongoing registry of consecutive patients with symptomatic, objectively confirmed, acute VTE. We analyzed the clinical characteristics and additional risk factors for VTE in all enrolled women aged <50 years who were using or not using contraceptives at presentation with VTE. Of 1,667 women aged <50 years enrolled in RIETE as of December 2007, 593 (36%) were contraceptive users. Of 270 aged <25 years, 190 (70%) were users. Ninety-two contraceptive users (16%) had overweight, 89 (15%) were obese. Of 951 women with no additional risk factors for VTE (i.e. recent surgery, immobility or cancer) 457 (48%) were contraceptive users. Eighty-seven (15%) users had recent immobility for >/=4 days, 44 (7.4%) were postoperative. The most common reason for immobility was lower limb trauma not requiring surgery; 25% of users with recent immobility had received thromboprophylaxis. The most common type of surgery was non-major orthopaedic surgery. Twenty-one (48%) users with postoperative VTE had received prophylaxis. The percentage of users and non-users who tested positive for thrombophilia was similar. Contraceptive use remains the most frequent risk factor for VTE in women at fertile age. Identifying those at increased risk for VTE seems to be difficult. In the meanwhile, a higher use of thromboprophylaxis during immobility or minor surgery should be warranted.

Published
2009

31. [Venous thromboembolism in patients with neurosurgical process or stroke. A prospective analysis from the RIETE registry].

Author

Blanco-Molina A, Palma I, Rubio C, Suárez C, Barba R, and Gutiérrez MR

Subjects
Aged, Anticoagulants therapeutic use, Female, Heparin, Low-Molecular-Weight therapeutic use, Humans, Male, Middle Aged, Postoperative Complications mortality, Postoperative Complications prevention & control, Prognosis, Pulmonary Embolism mortality, Registries, Risk Factors, Venous Thrombosis mortality, Neurosurgical Procedures mortality, Pulmonary Embolism prevention & control, Stroke mortality, Venous Thrombosis prevention & control
Abstract

Background and Objective: We studied the characteristics of thromboembolic disease in patients who have suffered a deep venous thrombosis or a pulmonary thromboembolism with the occurrence, two months before, of a neurosurgical process or a stroke., Patients and Method: We analyzed the variables of 57 patients who underwent a neurosurgical operation and those of 86 patients who suffered a stroke. These variables were included in the Computerised Records of Thromboembolic Disease., Results: The average age was of 62.3 (1.9) for neurosurgical and 71.7 (1.5) for stroke patients (p < 0.001). Prophylaxis was previously applied to 31.6% of neurosurgical patients and to 37.2% of patients in the stroke group. Most patients were treated with low molecular weight heparin during the acute phase of the illness. In both groups, 50% of deaths was associated with thromboembolic disease. The proportion of deceases was related to the associated disease and it was significantly higher in the stroke group (18% versus 4.2% in the neurosurgical group, p = 0.028)., Conclusions: In our study, thromboembolic disease was responsible of 50% of deaths. Stroke patients make up a group with a bad prognosis due to their older age and higher frequency of associated pathology; they have a higher risk of death.

Published
2004
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