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2. Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Author

Sánchez, Fernando Fernández, de Lomas, José Mª García, Rosas, Gabriel, de la Torre Lima, Javier, Bereciartua, Elena, Vidal, María José Blanco, Blanco, Roberto, Boado, María Victoria, Lázaro, Marta Campaña, Crespo, Alejandro, Carrión, Laura Guio, Del Álamo Martínez de Lagos, Mikel, Ugarte, Gorane Euba, Goikoetxea, Ane Josune, Hierro, Marta Ibarrola, Iruretagoyena, José Ramón, Zuazabal, Josu Irurzun, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, López, Mª Victoria García, Georgieva, Radka Ivanova, Ojeda, Guillermo, Bailón, Isabel Rodríguez, Morales, Josefa Ruiz, Rodríguez, Ignacio Álvarez, Galparsoro, Harkaitz Azkune, Boronat, Elisa Berritu, Odriozola, Mª Jesús Bustinduy, del Bosque Martín, Cristina, Echeverría, Tomás, Yarza, Alberto Eizaguirre, Fuentes, Ana, Goenaga, Miguel Ángel, del Río, Muskilda Goyeneche, Bauza, Ángela Granda, Iribarren, José Antonio, Urkola, Xabier Kortajarena, López, José Ignacio Pérez-Moreiras, Jiménez, Ainhoa Rengel, Reviejo, Karlos, Berbejillo, Alberto Sáez, Haza, Elou Sánchez, Alda, Rosa Sebastián, Ruiz, Itziar Solla, Ugartemendia, Irati Unamuno, Anza, Diego Vicente, Benito, Iñaki Villanueva, Arrieta, Mar Zabalo, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Bouzas, Alberto, Castelo, Brais, Cuenca, José, Gutiérrez, Laura, Ramos, Lucía, Mayo, María Rodríguez, Serrano, Joaquín Manuel, Regueiro, Dolores Sousa, Martínez, Francisco Javier, del Mar Alonso, Mª, Castro, Beatriz, Melian, Teresa Delgado, Sarabia, Javier Fernández, Rosado, Dácil García, González, Julia González, Lacalzada, Juan, de la Peña, Lissete Lorenzo, Ramírez, Alina Pérez, Arrondo, Pablo Prada, Moreno, Fermín Rodríguez, Ciezar, Antonio Plata, Iglesias, José Mª Reguera, Álvarez, Víctor Asensi, Costas, Carlos, de la Hera, Jesús, Suárez, Jonnathan Fernández, Fraile, Lisardo Iglesias, Arguero, Víctor León, Menéndez, José López, Bajo, Pilar Mencia, Morales, Carlos, Torrico, Alfonso Moreno, Palomo, Carmen, Martínez, Begoña Paya, Esteban, Ángeles Rodríguez, García, Raquel Rodríguez, Asensio, Mauricio Telenti, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Cuervo, Guillermo, Falces, Carlos, Fernández-Pittol, Mariana J, Fita, Guillermina, Fuster, David, de la Mària, Cristina García, García-Pares, Delia, Hernández-Meneses, Marta, Pérez, Jaume Llopis, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Roque, Mercè, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Alonso, David, Alonso, Juan Carlos, Álvarez-Uría, Ana, Bermejo, Javier, Bouza, Emilio, Caballero, Gregorio Cuerpo, Montero, Antonia Delgado, Estévez, Agustín, Ribas, Ramón Fortuny, Gargallo, Esther, Leoni, Mª Eugenia García, Mansilla, Ana González, Moraga, Francisco Javier González, Ramallo, Víctor González, Hernández, Martha Kestler, Hualde, Amaia Mari, Machado, Marina, Marín, Mercedes, Martínez-Sellés, Manuel, Melero, Rosa, Muñoz, Patricia, Monzón, Diego, Olmedo, María, Pedraz, Álvaro, Pinilla, Blanca, Pinto, Ángel, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Sánchez-Pérez, Eduardo, Segado, Antonio, Toledo, Neera, Valerio, Maricela, Vázquez, Pilar, Moreno, Eduardo Verde, de la Villa, Sofía, Antorrena, Isabel, Loeches, Belén, Moreno, Mar, Ramírez, Ulises, Bastón, Verónica Rial, Romero, María, Rosillo, Sandra, Balbín, Jesús Agüero, Fernández, Cristina Amado, Castillo, Carlos Armiñanzas, de las Revillas, Francisco Arnaiz, Belaustegui, Manuel Cobo, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Sampedro, Marta Fernández, García, Iván, Rico, Claudia González, Gutiérrez-Fernández, Laura, Gutiérrez-Cuadra, Manuel, Díez, José Gutiérrez, Pajarón, Marcos, Parra, José Antonio, Teira, Ramón, Zarauza, Jesús, Parra, Jorge Calderón, Cobo, Marta, Domínguez, Fernando, Pavía, Pablo García, Cruz, Ana Fernández, Ramos-Martínez, Antonio, Romero, Isabel Sánchez, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, del Río, Alejandro, Stuart, Jorge Rodríguez-Roda, Ruiz, Soledad, Tenorio, Carmen Hidalgo, Sequera, Sergio, Delia, Manuel Almendro, Araji, Omar, Barquero, José Miguel, Jambrina, Román Calvo, de Cueto, Marina, Acebal, Juan Gálvez, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, de Alarcón, Arístides, Gutiérrez-Carretero, Encarnación, Lepe, José Antonio, López-Haldón, José, Luque-Márquez, Rafael, Marín, Guillermo, Ortiz-Carrellán, Antonio, Sánchez-Domínguez, Eladio, Alonso, Luis Javier, Azcárate, Pedro, Gutiérrez, José Manuel Azcona, Blanco, José Ramón, Armas, Estíbaliz Corral, García-Álvarez, Lara, Oteo, José Antonio, Membrilla, Antonio Barros, Iglesias, Antonino Ginel, Grillo, Sara, Petracca, Rubén Leta, López-Contreras, Joaquín, Martínez, María Alba Rivera, Álvarez, M., Fernández, A.L., Martínez, Amparo, Prieto, A., Regueiro, Benito, Tijeira, E., Vega, Marino, Quiñonero, Amaia Aguirre, Miñambres, Ángela Alonso, Arana, Juan Carlos Gainzarain, de Alaiza Ortega, Sara González, Rodríguez, Miguel Ángel Morán, Rodríguez, Anai Moreno, de Zárate, Zuriñe Ortiz, Zapirain, José Joaquín Portu, de Adana Arroniz, Ester Sáez, Sánchez, Daisy Carolina Sorto, Antonio, Sánchez-Porto, Alejandro, Úbeda Iglesias, Leal, José Mª Arribas, Vázquez, Elisa García, Torres, Alicia Hernández, Blázquez, Ana, de la Morena Valenzuela, Gonzalo, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Tarabini-Castellani, Paola, Gálvez, Eva Heredero, Bellido, Carolina Maicas, Pau, José Largo, Sepúlveda, Mª Antonia, Sierra, Pilar Toledano, Iqbal-Mirza, Sadaf Zafar, Alcolea, Eva Cascales, Yañez, Ivan Keituqwa, Martínez, Julián Navarro, Ballesta, Ana Peláez, Escobar, Eduardo Moreno, Monje, Alejandro Peña, Cabrera, Valme Sánchez, García, David Vinuesa, Asenjo, María Arrizabalaga, Luna, Carmen Cifuentes, Morcillo, Juana Núñez, Seco, Mª Cruz Pérez, Gelabert, Aroa Villoslada, Guallar, Carmen Aured, Abad, Nuria Fernández, Mangas, Pilar García, Adell, Marta Matamala, Ruiz, Mª Pilar Palacián, Porres, Juan Carlos, Vidal, Begoña Alcaraz, Del Amor Espín, María Jesús, Buendía, Francisco, Sánchez, Roberto Jiménez, Mármol, Rosario, Martínez, Francisco, Meseguer, Antonio, Pérez, Beatriz, Risco, Leticia, Saura, Zoser, Silva, Vanina, Villmarín, Mª Belén, Blanco, Mª Ángels Ribas, de Gopegui Bordes, Enrique Ruiz, Bonet, Laura Vidal, Borràs, Miquel Vives, Munera, Mª Carmen Bellón, Garaizabal, Elena Escribano, Martínez, Antonia Tercero, Luque, Juan Carlos Segura, Badía, Cristina, Palop, Lucía Boix, Xercavins, Mariona, Ibars, Sónia, Bosch, Xerach, Nebreda, Eloy Gómez, Herrera, Ibalia Horcajada, Gallego, Irene Menduiña, Pulido, Imanol, Santiago, Héctor Marrero, de Miguel Martínez, Isabel, Álamo, Elena Pisos, Sánchez, Daniel San Román, Pérez, Jorge Boan, Blanco, Eva Mª Aguilar, González, Mercedes Catalán, Peiretti, María Angélica Corres, Esteve, Andrea Eixerés, Pérez, Laura Domínguez, de Cossío Tejido, Santiago, Román, Francisco Galván, Robles, José Antonio García, Medrano, Francisco López, Gude, Mª Jesús López, Miguel, Mª Ángeles Orellana, Pilkington, Patrick, Ostalaza, Yolanda Revilla, Morales, Juan Ruiz, Solís, Sebastián Ruiz, Collado, Ana Sabín, Fernández, Marcos Sánchez, Rallo, Javier Solera, Martín, Jorge Solís, Escrihuela-Vidal, Francesc, Carratalà, Jordi, Grau, Inmaculada, Ardanuy, Carmen, Berbel, Dámaris, Salado, José Carlos Sánchez, Alegre, Oriol, Majoral, Alejandro Ruiz, Sbraga, Fabrizio, Blasco, Arnau, Sánchez, Laura Gracia, Sánchez-Rodríguez, Iván, Aldamiz, Gonzalo, Álvarez, Beatriz, Palacios, Marina Bernal, Úbeda, Alfonso Cabello, Roblas, Ricardo Fernández, Hernández, Rafael, Martín, Victoria Andrea Hortigüela, Kallmeyer, Andrea, Kancev, Cristina Landaeta, Martín, Marta, Ruiz, Miguel Morante, Lobato, Miguel Ángel Navas, Pello, Ana María, Prieto, Laura, Mallebrera, Marta Tomás, Varela, Laura, de la Peña Triguero, Mireia, Cerón, Ruth Esther Figueroa, Gómez, Lara Ruiz, Ble, Mireia, Gallego, Juan Pablo Horcajada, Ginel, Antonio José, López, Inmaculada, Mas, Alexandra, Mestres, Antoni, Molina, Lluís, Serrat, Ramón, Ribas, Núria, Sánchez, Francisca, Silverio, Ana, Suárez, Marina, Sorlí, Luisa, Recasens, Lluís, Taurón, Manuel, Regueras, María Fernández, Vallejo, María Ángeles Mantecón, Rivera, José Ángel Pérez, Mata, Nuria Sánchez, Cano, Antonia Calvo, Olivares, Miguel Fajardo, Núñez, María Victoria Millán, Sanz, Agustín Muñoz, Herrera-Hidalgo, Laura, Alonso-Menchén, David, Luque-Marquez, Rafael, Fariñas, María Del Carmen, Miró, Jose Maria, Goenaga, Miguel Angel, Angulo-Lara, Basilio, and Boix-Palop, Lucia

Published
2023
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3. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Jarrín, Inma, Dalmau, David, Navarro, M. Luisa, González, M. Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, González, Juan, Muñoz-Fernández, M. Ángeles, Jarrín, Inmaculada, Moreno, Cristina, Rava, Marta, Izquierdo, Rebeca, Mauleón, Elba, Portilla, Joaquín, Portilla, Irene, Merino, Esperanza, García, Gema, Agea, Iván, Sánchez-Payá, José, Rodríguez, Juan Carlos, Giner, Livia, Reus, Sergio, Boix, Vicente, Torrus, Diego, Pérez, Verónica, Portilla, Julia, Gómez, Juan Luís, Hernández, Jehovana, Lirola, Ana López, García, Dácil, Díaz-Flores, Felicitas, Alonso, M. Mar, Pelazas, Ricardo, Alemán, M. Remedios, Asensi, Víctor, Rivas Carmenado, María Eugenia, Suarez-Zarracina, Tomás, Pulido, Federico, Bisbal, Otilia, Hernando, M. Asunción, Rial, David, de Lagarde, María, Arce, Octavio, Pinto, Adriana, Bermejo, Laura, Santacreu, Mireia, Navarro, Roser, Gonzalez, Candela, Aramburu, M. José, Camino, Xabier, Ángel von Wichmann, Miguel, Goenaga, Miguel Ángel, Bustinduy, M. Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Kortajarena, Xabier, Álvarez-Rodriguez, Ignacio, Gil, Leire, Martínez, Lourdes, Robledano, Catalina, Masiá, Mar, Padilla, Sergio, Adsuar, Araceli, Pascual, Rafael, Fernández, Marta, Galiana, Antonio, García, José Alberto, Barber, Xavier, Agullo, Vanessa, Abellán, Javier Garcia, Pascual, Reyes, Telenti, Guillermo, Guillén, Lucia, Botella, Ángela, Muga, Roberto, Sanvisens, Arantza, Fuster, Daniel, Gutierrez, Isabel, López, Juan Carlos, Ramírez, Margarita, Padilla, Belén, Gijón, Paloma, Aldamiz-Echevarría, Teresa, Tejerina, Francisco, Diez, Cristina, Pérez, Leire, Fanciulli, Chiara, Corral, Saray, Martí, Anna, Peraire, Joaquín, Viladés, Consuelo, Vargas, Montserrat, Olona, Montserrat, Rull, Anna, Alba, Verónica, Yeregui, Elena, Masip, Jenifer, García-Pardo, Graciano, Bertomeu, Frederic Gómez, Espineira, Sonia, Montero, Marta, Cuéllar, Sandra, Blanes, Marino, Tasias, María, Calabuig, Eva, Salavert, Miguel, Fernández, Juan, Segarra, Inmaculada, González-García, Juan, Delgado, Ana, Arnalich, Francisco, Arribas, José Ramón, Bernardino, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontañón, Victor, García-Bujalance, Silvia, García, Milagros, González-Baeza, Alicia, Martín-Carbonero, M. Luz, Mayoral, Mario, Mellado, M. Jose, Esteban, Rafael, Montejano, Rocío, Montes, M. Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Rúa, Guadalupe, Sainz, Talía, Sendagorta, Elena, Valencia, Eulalia, Busca, Carmen, Cano, Joanna, Cardiñanos, Julen, de Miguel, Rosa, Blanco, Jose Ramón, Pérez-Martínez, Laura, Oteo, José Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria, Martinez, Marina, Jaén, Angels, Sanmartí, Montse, Cairó, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemí, Aiello, Francesco, Rivero, María, Piérola, Beatriz, Goikoetxea, Maider, Gracia, María, Ibero, Carlos, Moreno, Estela, Repáraz, Jesús, Navarro, Gemma, Garcia, Manel Cervantes, Isbert, Sonia Calzado, Vilasaro, Marta Navarro, Garcia, Belen Lopez, Santos, Ignacio de los, Santos, Alejandro de los, Sanz, Jesús, García-Fraile, Lucio, Martín, Enrique, Sánchez-Cerrillo, Ildefonso, Calvet, Marta, Barrios, Ana, Bautista, Azucena, Sáez, Carmen, Ciudad, Marianela, Gutiérrez, Ángela, Moreno, Santiago, Campo, Santos del, Casado, José Luis, Dronda, Fernando, Moreno, Ana, Pérez, M. Jesús, Serrano, Sergio, Vivancos, M<ce:sup loc='post">a</ce:sup> Jesús, Martínez-Sanz, Javier, Vallejo, Alejandro, Sanchez, Matilde, Pérez-Molina, Jose Antonio, Hermida, José Manuel, Bernal, Enrique, Alcaraz, Antonia, Bravo, Joaquín, Muñoz, Ángeles, Tomás, Cristina, Martínez, Mónica, Villalba, M. Carmen, García, Federico, Martínez, Clara, Hernández, José, Medina, Leopoldo Muñoz, Álvarez, Marta, Chueca, Natalia, Vinuesa, David, de Salazar, Adolfo, Fuentes, Ana, Guirao, Emilio, Viñuela, Laura, Ruiz-Sancho, Andrés, Anguita, Francisco, Del Romero, Jorge, Raposo, Montserrat, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Baza, Begoña, Orviz, Eva, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María, Ribas, M. Angels, Campins, Antoni A., Garcia-Gazalla, Mercedes, Fanjul, Francisco J., Murillas, Javier, Homar, Francisco, Vilchez, Helem H., Martin, Luisa, Payeras, Antoni, Santos, Jesús, López, María, Gómez, Crisitina, Viciana, Isabel, Palacios, Rosario, López-Cortés, Luis Fernando, Espinosa, Nuria, Roca, Cristina, Llaves, Silvia, Tiraboschi, Juan Manuel, Imaz, Arkaitz, Silva, Ana Karina, Saumoy, María, Scévola, Sofía Catalina, Curran, Adrián, Falcó, Vicenç, Navarro, Jordi, Burgos, Joaquin, Suanzes, Paula, García, Jorge, Descalzo, Vicente, Álvarez, Patricia, Planas, Bibiana, Sanchiz, Marta, Rodríguez, Lucía, Olalla, Julián, Sánchez, M José, Pérez, Javier, Arco, Alfonso del, Torre, Javier de la, Prada, José Luis, Martínez, Onofre Juan, Martinez, Lorena, Vera, Francisco Jesús, García, Josefina, Alcaraz, Begoña, Sánchez Guirao, Antonio Jesús, Mena, Alvaro, Castro, Angeles, Pernas, Berta, Vázquez, Pilar, López, Soledad, Ibarra, Sofía, García, Guillermo, Mirena, Josu, Ferrero, Oscar Luis, López, Josefina, Cámara, M. Mar, Peña, Mireia de la, Lopez, Miriam, Lopez, Iñigo, Lombide, Itxaso, Polo, Victor, de Miguel, Joana, Galera, Carlos, Fernández, Marian, Albendin, Helena, Castillo, Antonia, Iborra, Asunción, Moreno, Antonio, Merlos, M. Angustias, Vidal, Asunción, Amador, Concha, Pasquau, Francisco, Gil, Concepcion, Algado, Jose Tomás, Suarez-García, Inés, Malmierca, Eduardo, González-Ruano, Patricia, Ruiz, M. Pilar, Pascual, José Francisco, Sáez, Elena, Balsalobre, Luz, López, M. Villa, Omar, Mohamed, Herrero, Carmen, Gómez, M. Amparo, Alberto de Zarraga, Miguel, Pérez, Desiré, Estrada, Vicente, Sanz, Nieves, Cabello, Noemí, García, Jorge Vergas, Núñez, Maria Jose, Sagastagoitia, Iñigo, Górgolas, Miguel, Cabello, Alfonso, Álvarez, Beatriz, Prieto, Laura, Carrillo, Irene, Sanz, José, Arranz, Alberto, Hernández, Cristina, Novella, María, Galindo, M. José, Ferrer, Ana, Román, Antonio Rivero, Ruíz, Inma, Juárez, Antonio Rivero, López, Pedro, Machuca, Isabel, Frias, Mario, Camacho, Ángela, Pérez, Ignacio, Corona, Diana, Cervero, Miguel, Torres, Rafael, Pineda, Juan Antonio, Rincón, Pilar, Macías, Juan, Real, Luis Miguel, Corma, Anais, Gonzalez-Serna, Alejandro, Pérez, Alexandre, Morano, Luis, Miralles, Celia, Ocampo, Antonio, Pousada, Guillermo, Patiño, Lucía, Dueñas, Carlos, Gutiérrez, Sara, Tapia, Elena, Novoa, Cristina, Egües, Xjoylin, Telleria, Pablo, Díaz-Álvarez, Jorge, Rosas Cancio-Suarez, Marta, Ron, Raquel, Iribarren, José Antonio, Ruiz Sancho, Andrés, Cabello, Noemi, and Serrano-Villar, Sergio

Published
2023
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5. Loneliness and social isolation in people with HIV aged ≥50 years. The No One Alone (NOA)‐GeSIDA study conducted by the GeSIDA 12021 study group.

Author

Blanco, José‐Ramón, Gonzalez‐Baeza, Alicia, Martinez‐Vicente, Ana, Albendin‐Iglesias, Helena, De La Torre, Javier, Jarrin, Inma, González‐Cuello, Inmaculada, Cabello‐Clotet, Noemí, Barrios‐Blandino, Ana‐María, Sanjoaquin‐Conde, Isabel, Montes‐Ramirez, Mª‐Luisa, Melus, Estrella, Pérez‐Esquerdo, Verónica, Tomas‐Jimenez, Cristina, Saumoy‐Linares, María, Lopez‐Lirola, Ana‐Mª, Hidalgo‐Tenorio, Carmen, Muelas‐Fernandez, Magdalena, Galindo‐Puerto, Mª‐José, and Abadía, Jessica

Abstract

Introduction Methods Results Conclusions There is a growing number of people with HIV who are aged 50 years or older, and the prevalence of loneliness and social isolation remains unknown.A multicentre study was conducted across 22 GeSIDA centres. A survey was carried out to assess loneliness [UCLA 3‐item Loneliness Scale‐3 (UCLA‐3)] and social isolation [Lubben Social Network Scale‐Revised (LSNS‐R)], along with sociodemographic aspects, HIV‐related factors, comorbidities, tobacco, alcohol and drug consumption, quality of life, anxiety and depression, and stigma. The prevalence of loneliness (UCLA‐3 ≥ 6) and evident social isolation (LSNS‐R ≤ 20) was calculated, and multivariable multinominal logistic regression models were used to identify associated factors.A total of 399 people with HIV were included; 77.4% were men, of average age 59.9 years (SD 6.5); 45.1% were aged ≥60 years; 86% were born in Spain; 86.7% in urban areas; 56.4% with secondary or higher education; 4.5% living alone against their wishes. A total of 66.9% were infected through sexual transmission, with a median of 22.9 years since diagnosis [interquartile range (IQR): 12.6–29.5] and a median nadir CD4 count of 245 cells/μL (IQR: 89–440). Overall, 90.7% had viral load <50 copies/mL, 93.5% had adherence >95%, and 26.3% had a prior AIDS diagnosis. In all, 29.1% and 21% reported significant symptoms of anxiety and depression, respectively, 24.3% had mobility issues, and 40.8% reported pain. Overall, 77.7% of participants reported neither loneliness nor social isolation, 10.0% loneliness only, 5.8% social isolation only and 6.5% both. Multivariable analyses identified that being aged 50–59, unemployed or retired, living alone unwillingly, single, poor quality of life, anxiety, and HIV‐related stigma were associated with loneliness. Meanwhile, lower education, living alone unwillingly, and depressive symptoms were associated with social isolation. Individuals living alone unwillingly, with depressive symptoms and experiencing HIV‐related stigma were at higher risk for both loneliness and social isolation.There is a relatively high prevalence of loneliness and social isolation in our population. Living alone against one's wishes, being unmarried, and experiencing mobility issues could predispose individuals to feel lonely and socially isolated. Those with anxiety and stigma are more prone to loneliness, while individuals with depression are more predisposed to social isolation. It is necessary to develop strategies for the detection and management of loneliness and social isolation in people with HIV aged >50 years. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Pulmonary long-term consequences of COVID-19 infections after hospital discharge

Author

Blanco, Jose-Ramon, Cobos-Ceballos, Maria-Jesus, Navarro, Francisco, Sanjoaquin, Isabel, Arnaiz de las Revillas, Francisco, Bernal, Enrique, Buzon-Martin, Luis, Viribay, Miguel, Romero, Lourdes, Espejo-Perez, Simona, Valencia, Borja, Ibañez, David, Ferrer-Pargada, Diego, Malia, Damian, Gutierrez-Herrero, Fernando-Gustavo, Olalla, Julian, Jurado-Gamez, Bernabe, and Ugedo, Javier

Published
2021
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8. The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion

Author

Tenthorey, Jeannette L, Haloupek, Nicole, López-Blanco, José Ramón, Grob, Patricia, Adamson, Elise, Hartenian, Ella, Lind, Nicholas A, Bourgeois, Natasha M, Chacón, Pablo, Nogales, Eva, and Vance, Russell E

Subjects
Vaccine Related, Prevention, Emerging Infectious Diseases, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Animals, Apoptosis Regulatory Proteins, Calcium-Binding Proteins, Cryoelectron Microscopy, Flagellin, HEK293 Cells, Host-Pathogen Interactions, Humans, Immunity, Innate, Inflammasomes, Legionella pneumophila, Mice, Mutation, Neuronal Apoptosis-Inhibitory Protein, Protein Domains, General Science & Technology
Abstract

Robust innate immune detection of rapidly evolving pathogens is critical for host defense. Nucleotide-binding domain leucine-rich repeat (NLR) proteins function as cytosolic innate immune sensors in plants and animals. However, the structural basis for ligand-induced NLR activation has so far remained unknown. NAIP5 (NLR family, apoptosis inhibitory protein 5) binds the bacterial protein flagellin and assembles with NLRC4 to form a multiprotein complex called an inflammasome. Here we report the cryo-electron microscopy structure of the assembled ~1.4-megadalton flagellin-NAIP5-NLRC4 inflammasome, revealing how a ligand activates an NLR. Six distinct NAIP5 domains contact multiple conserved regions of flagellin, prying NAIP5 into an open and active conformation. We show that innate immune recognition of multiple ligand surfaces is a generalizable strategy that limits pathogen evolution and immune escape.

Published
2017

9. Effects of first-line antiretroviral therapy on the CD4/CD8 ratio and CD8 cell counts in CoRIS: a prospective multicentre cohort study

Author

Jarrin, Inmaculada, Moreno, Santiago, Alejos, Belén, Muñoz-Fernández, MÁngeles, Consuegra, Irene, Merino, Esperanza, García, Gema, Lirola, Ana López, García, Dácil, Asensi, Víctor, Valle, Eulalia, Rubio, Rafael, Pulido, Federico, Iribarren, José Antonio, Arrizabalaga, Julio, Gutiérrez, Félix, Masiá, Mar, Muga, Roberto, Sanvisens, Arantza, Berenguer, Juan, Vidal, Francesc, Montero, Marta, Blanco, José Ramón, López Bernarlo de Quirós, Juan Carlos, González-Garcia, Juan, Peraire, Joaquín, Arazo, Piedad, López-Aldeguer, José, Dalmau, David, Arnalich, Francisco, Rivero, Maria, Oteo, José Antonio, Sampériz, Gloria, Amengual, María José, Jaén, Angels, de los Santos, Ignacio, Repáraz, Jesús, Navarro, Gemma, Bernal, Enrique, Sanz, Jesús, Viciana, Pompeyo, García, Federico, Casado, José Luis, Del Romero, Jorge, Cano, Alfredo, Antela, Antonio, Quero, José Hernández, Riera, Melchor, Raposo, Montserrat, Santos, Jesús, Losada, Elena, Daniel, Podzamczer, Peñaranda, María, Ayerbe, Cristina Gómez, Espinosa, Nuria, Olalla, Julián, Imaz, Arkaitz, Martínez, Onofre, Curran, Adrian, Castro, Ángeles, Pérez Stachowski, Javier, Muñoz, Josefa, Vera, Francisco Jesús, Galera, Carlos, Pernas, Berta, Amador, Concha, Zuriñe, Miren, Albendin, Helena, Suárez-García, Inés, Pasquau, Francisco, Omar, Mohamed, Malmierca, Eduardo, de Zarraga, Miguel Alberto, Gómez Vidal, María Amparo, Estrada, Vicente, Górgolas, Miguel, Sanz, José, Téllez, María Jesús, Galindo, María José, Cabello, Alfonso, Rivero, Antonio, Arranz, Alberto, Cervero, Miguel, Vilalta, Ramón, Pineda, Juan A, Rivero-Juárez, Antonio, Torres, Rafael, Poveda, Eva, Rincón, Pilar, Pérez, Alexandre, Moreno, Cristina, Portilla, Irene, Díaz-Flores, Felicitas, Rivas, María E, Bisbal, Otilia, Aramburu, María J, Padilla, Sergio, Fuster, Daniel, Gutiérrez, Isabel, Viladés, Consuelo, Blanes, Marino, Arribas, José Ramón, Ibarra, Valvanera, Sanmartí, Montse, de Alda, María Ruiz, Cervantes, Manel, Salas, Ana, Dronda, Fernando, Alcaraz, Antonia, Muñoz, Leopoldo, Rodríguez, Carmen, Ribas, María Angels, Viciana, Isabel, López-Cortés, Luis, Tiraboschi, Juan, del Arco, Alfonso, Martínez, Lorena, Mena, Álvaro, Mirena, Josu, Pérez, Aurora, Ena, Javier, González-Ruano, Patricia, Vergas, Jorge, Álvarez, Beatriz, Hernández, Cristina, Ferrer, Ana, López, Pedro, Macías, Juan, Crespo, Manuel, Navarro, Maria Luisa, Iniesta, Carlos, Agea, Iván, Gómez, Juan Luis, Suárez-Zarracina, Tomás, Hernando, Asunción, Camino, Xabier, Robledano, Catalina, Ramírez, Margarita, Veloso, Sergio, Tasias, María, Bernardino, Jose Ignacio, Metola, Luis, Cairó, Mireia, de León Cano, María Teresa, Calzado, Sonia, Sarria, Cristina, Moreno, Ana, Bravo, Joaquín, Alvarez, Marta, Puerta, Teresa, Campins, Antoni A, Palacios, Rosario, Silva, Ana, de la Torre, Javier, García, Josefina, Ibarra, Sofía, Iborra, Asunción, Benito, Concha, Martín, Dolores, Pérez-Somarriba, Juncal, Prieto, Laura, Novella, María, Machuca, Isabel, Merchante, Nicolás, Morano, Luis, González, Maria Isabel, García, Luis NM, Portilla, Joaquín, Alonso, María del Mar, Pérez, Laura, Domínguez, Lourdes, Rodríguez-Arrondo, Francisco, Colomé, Joan Gregori, Padilla, Belén, Vargas, Montserrat, Castro, Iván, Castro, Juan Miguel, Sanz, Mercedes, Martinez-Lacasa, Javier, Pierola, Beatriz, Navarro, Marta, Garcia-Fraile, Lucio, Pérez-Elias, Maria Jesús, Muñoz, Ángeles, Chueca, Natalia, Carrió, Juan Carlos, Vidal, Carmen, Pérez, Carmen, Saumoy, María, Prada, José Luis, Alcaraz, Begoña, Ferrero, Oscar, Moreno, Antonio, Fenoll, Vicenta, Ruiz, Mª Pilar, Frias, Mario, Real, Luis Miguel, Miralles, Celia, Garcia, Federico, Sanz, Nieves, Sánchez-Payá, José, Pelazas, Ricardo, Rial, David, von Wichman, Miguel Ángel, Adsuar, Araceli, Gijón, Paloma, Olona, Montserrat, Calabuig, Eva, Delgado, Ana, Pérez-Martínez, Laura, Velli, Pablo, Martín-Gayo, Enrique, Gutiérrez, Carolina, Alcaraz, Maria José, Vinuesa, David, Vera, Mar, Fanjul, Francisco, Gonzalez-Domenec, Carmen, Prieto, Paula, de las Lomas, José N García, Jimeno, Amaya, López, Josefina, Merlos, Maria, Gil, Concepción, Camacho, Angela, Corma, Anais, Ocampo, Antonio, Rava, Marta, Rodríguez, Juan Carlos, Hernández, Jehovana, Bermejo, Laura, Pascual, Lidia, Pascual, Rafael, Aldamiz-Echevarría, Teresa, Rull, Anna, Cuéllar, Sandra, Escosa, Luis, Font, Roser, Madrid, Nadia, del Carmen Villalba, Maria, Martinez-Montes, Clara, Ballesteros, Juan, Murillas, Javier, Cámara, María Mar, Vidal, Asunción, Algado, José Tomas, Fernández, Marta, Pousada, Guillermo, Iribarren, Jose Antonio, Gimeno, Lina, Alemán, María Remedios, Santacreu, Mireia, Goenaga, Miguel Ángel, Tejerina, Francisco, Rodríguez-Gallego, Esther, Salavert, Miguel, Herranz, Pedro, Martinez, Marina, del Campo, Santos, Guerrero, Carlos, Ayerdi, Oskar, Homar, Francisco, de la Peña, Mireia, Meca, Marisa, Díez, Marcos, Azkune, Harkaitz, Barber, Xavier, Balsalobre, Pascual, Castellanos, Alfonso Javier, García-Bujalance, Silvia, Vivancos, Maria Jesús, Fuentes, Ana, Martin, Maria Luisa, Lopez, Iñigo, Vilchez, Helem, Lopez, Miriam, Carreres, Melissa, Ibarguren, Maialen, Agullo, Vanessa, Diez, Cristina, López-Dupla, Miguel, García, Milagros, Umerez, Maitane, Martínez-Sanz, Javier, Payeras, Antoni, Reus, Sergio, Lizardi, Aitziber, Garcia, Javier, Pérez, Leire, González-Baeza, Alicia, Anxa, Usua, González, Juan, Boix, Vicente, Kortajarena, Xabier, Pascual, Reyes, Fanciulli, Chiara, Martín-Carbonero, Maria Luz, Mellado, Maria José, Micán, Rafael, Montejano, Rocio, Montes, María Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rúa, Guadalupe, Rodés, Berta, Sainz, Talia, Sendagorta, Elena, Stella, Natalia, Valencia, Eulalia, Velasco, Tamara, Muñoz-Fernández, María Ángeles, Torrús, Diego, Carmona, María Pilar, Roca, María, Mayoral, Mario, Vallejo, Alejandro, Serrano-Villar, Sergio, Ron, Raquel, Talavera-Rodríguez, Alba, Fernández-Felix, Borja M, Herrera, Sabina, Muriel, Alfonso, de Zárraga, Miguel Alberto, and Vivancos, María J

Published
2020
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11. Structure of promoter-bound TFIID and model of human pre-initiation complex assembly

Author

Louder, Robert K, He, Yuan, López-Blanco, José Ramón, Fang, Jie, Chacón, Pablo, and Nogales, Eva

Subjects
Genetics, Underpinning research, Aetiology, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Generic health relevance, Cryoelectron Microscopy, DNA, Humans, Models, Molecular, Promoter Regions, Genetic, Protein Binding, Substrate Specificity, TATA Box, TATA-Binding Protein Associated Factors, TATA-Box Binding Protein, Transcription Factor TFIIA, Transcription Factor TFIID, Transcription Initiation, Genetic, General Science & Technology
Abstract

The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. Here we present the structure of human TFIID in complex with TFIIA and core promoter DNA, determined by single-particle cryo-electron microscopy at sub-nanometre resolution. All core promoter elements are contacted by subunits of TFIID, with TAF1 and TAF2 mediating major interactions with the downstream promoter. TFIIA bridges the TBP-TATA complex with lobe B of TFIID. We also present the cryo-electron microscopy reconstruction of a fully assembled human TAF-less PIC. Superposition of common elements between the two structures provides novel insights into the general role of TFIID in promoter recognition, PIC assembly, and transcription initiation.

Published
2016

12. Should We Expect an Increase in the Number of Cancer Cases in People with Long COVID?

Author

Amiama-Roig, Ana [0000-0003-3326-585X], Verdugo-Sivianes, Eva M. [0000-0002-0922-0371], Blanco, José Ramón [0000-0002-4268-0150], Amiama-Roig, Ana, Pérez-Martínez, Laura, Rodríguez Ledo, Pilar, Verdugo-Sivianes, Eva M., Blanco, José Ramón, Amiama-Roig, Ana [0000-0003-3326-585X], Verdugo-Sivianes, Eva M. [0000-0002-0922-0371], Blanco, José Ramón [0000-0002-4268-0150], Amiama-Roig, Ana, Pérez-Martínez, Laura, Rodríguez Ledo, Pilar, Verdugo-Sivianes, Eva M., and Blanco, José Ramón

Abstract

The relationship between viral infections and the risk of developing cancer is well known. Multiple mechanisms participate in and determine this process. The COVID-19 pandemic caused by the SARS-CoV-2 virus has resulted in the deaths of millions of people worldwide. Although the effects of COVID-19 are limited for most people, a large number of people continue to show symptoms for a long period of time (long COVID). Several studies have suggested that cancer could also be a potential long-term complication of the virus; however, the causes of this risk are not yet well understood. In this review, we investigated arguments that could support or reject this possibility.

Published
2023

15. Role of age and comorbidities in mortality of patients with infective endocarditis

Author

Armiñanzas, Carlos, Fariñas-Alvarez, Concepción, Zarauza, Jesús, Muñoz, Patricia, González Ramallo, Víctor, Martínez Sellés, Manuel, Miró Meda, José Mª., Pericás, Juan Manuel, Goenaga, Miguel Ángel, Ojeda Burgos, Guillermo, Rodríguez Álvarez, Regino, Castelo Corral, Laura, Gálvez-Acebal, Juan, Martínez Marcos, Francisco Javier, Fariñas, Maria Carmen, Fernández Sánchez, Fernando, Noureddine, Mariam, Rosas, Gabriel, de la Torre Lima, Javier, Aramendi, José, Bereciartua, Elena, Blanco, María José, Blanco, Roberto, Boado, María Victoria, Campaña Lázaro, Marta, Crespo, Alejandro, Goikoetxea, Josune, Iruretagoyena, José Ramón, Irurzun Zuazabal, Josu, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, García López, Mª. Victoria, Georgieva, Radka Ivanova, Ojeda, Guillermo, Rodríguez Bailón, Isabel, Ruiz Morales, Josefa, Cuende, Ana María, Echeverría, Tomás, Fuerte, Ana, Gaminde, Eduardo, Idígoras, Pedro, Iribarren, José Antonio, Izaguirre Yarza, Alberto, Kortajarena Urkola, Xabier, Reviejo, Carlos, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Miguez Rey, Enrique, Rodríguez Mayo, María, Sánchez, Efrén, Sousa Regueiro, Dolores, Martínez, Francisco Javier, Alonso, Mª. del Mar, Castro, Beatriz, García Rosado, Dácil, Durán, Mª. del Carmen, Miguel Gómez, Mª. Antonia, Lacalzada, Juan, Nassar, Ibrahim, Plata Ciezar, Antonio, Reguera Iglesias, José Mª., Asensi Álvarez, Víctor, Costas, Carlos, de la Hera, Jesús, Fernández Suárez, Jonnathan, Iglesias Fraile, Lisardo, León Arguero, Víctor, López Menéndez, José, Mencia Bajo, Pilar, Morales, Carlos, Moreno Torrico, Alfonso, Palomo, Carmen, Paya Martínez, Begoña, Rodríguez Esteban, Ángeles, Rodríguez García, Raquel, Telenti Asensio, Mauricio, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Falces, Carlos, Fita, Guillermina, Fuster, David, García de la Mària, Cristina, Hernández-Meneses, Marta, Llopis Pérez, Jaume, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Bermejo, Javier, Bouza, Emilio, Celemín, Daniel, Cuerpo Caballero, Gregorio, Delgado Montero, Antonia, Fernández Cruz, Ana, García Mansilla, Ana, García Leoni, Mª. Eugenia, Kestler Hernández, Martha, Hualde, Amaia Mari, Marín, Mercedes, Martínez-Sellés, Manuel, Menárguez, Mª. Cruz, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Pinilla, Blanca, Pinto, Ángel, Valerio, Maricela, Vázquez, Pilar, Verde Moreno, Eduardo, Antorrena, Isabel, Loeches, Belén, Martín Quirós, Alejandro, Moreno, Mar, Ramírez, Ulises, Rial Bastón, Verónica, Romero, María, Saldaña, Araceli, Agüero Balbín, Jesús, Amado, Cristina, Armiñanzas Castillo, Carlos, Arnaiz García, Ana, Cobo Belaustegui, Manuel, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Gómez Izquierdo, Rubén, García, Iván, González-Rico, Claudia, Gutiérrez-Cuadra, Manuel, Gutiérrez Díez, José, Pajarón, Marcos, Parra, José Antonio, Sarralde, Aurelio, Teira, Ramón, Domínguez, Fernando, García Pavía, Pablo, González, Jesús, Orden, Beatriz, Ramos, Antonio, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, del Río, Alejandro, Ruiz, Soledad, Hidalgo Tenorio, Carmen, Almendro Delia, Manuel, Araji, Omar, Barquero, José Miguel, Calvo Jambrina, Román, de Cueto, Marina, Gálvez Acebal, Juan, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, de Alarcón, Arístides, García, Emilio, Haro, Juan Luis, Lepe, José Antonio, López, Francisco, Luque, Rafael, Alonso, Luis Javier, Azcárate, Pedro, Azcona Gutiérrez, José Manuel, Blanco, José Ramón, García-Álvarez, Lara, Oteo, José Antonio, Sanz, Mercedes, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Álvarez, M., Fernández, A.L., Martínez, Amparo, Prieto, A., Regueiro, Benito, Tijeira, E., Vega, Marino, Canut Blasco, Andrés, Cordo Mollar, José, Gainzarain Arana, Juan Carlos, García Uriarte, Oscar, Martín López, Alejandro, Ortiz de Zárate, Zuriñe, Urturi Matos, José Antonio, García Domínguez, Gloria, Sánchez-Porto, Antonio, Arribas Leal, José Mª., García Vázquez, Elisa, Hernández Torres, Alicia, Blázquez, Ana, de la Morena Valenzuela, Gonzalo, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Moreno Rodríguez, Anai, Tarabini-Castellani, Paola, Heredero Gálvez, Eva, Maicas Bellido, Carolina, Largo Pau, José, Sepúlveda, Mª. Antonia, Toledano Sierra, Pilar, Iqbal-Mirza, Sadaf Zafar, Cascales Alcolea, Eva, Egea Serrano, Pilar, Hernández Roca, José Joaquín, Keituqwa Yañez, Ivan, Peláez Ballesta, Ana, Soriano, Víctor, Moreno Escobar, Eduardo, Peña Monje, Alejandro, Sánchez Cabrera, Valme, Vinuesa García, David, Arrizabalaga Asenjo, María, Cifuentes Luna, Carmen, Núñez Morcillo, Juana, Pérez Seco, Mª. Cruz, Villoslada Gelabert, Aroa, Aured Guallar, Carmen, Fernández Abad, Nuria, García Mangas, Pilar, Matamala Adell, Marta, Palacián Ruiz, Mª. Pilar, Porres, Juan Carlos, Alcaraz Vidal, Begoña, Cobos Trigueros, Nazaret, Del Amor Espín, María Jesús, Giner Caro, José Antonio, Jiménez Sánchez, Roberto, Jimeno Almazán, Amaya, Ortín Freire, Alejandro, Viqueira González, Monserrat, Pericás Ramis, Pere, Ribas Blanco, Mª. Ángels, Ruiz de Gopegui Bordes, Enrique, Vidal Bonet, Laura, Bellón Munera, Mª. Carmen, Escribano Garaizabal, Elena, Tercero Martínez, Antonia, and Segura Luque, Juan Carlos

Published
2019
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17. Executive summary of the GeSIDA/National AIDS Plan consensus document on antiretroviral therapy in adults infected by the human immunodeficiency virus (updated January 2018)

Author

Pérez-Molina, José A., Polo, Rosa, López-Aldeguer, José, Lozano, Fernando, Aguirrebengoa, Koldo, Arribas, José Ramón, Boix, Vicente, Berenguer, Juan, Blanco, José Ramón, Domingo, Pere, Estrada, Vicente, Galindo, María José, García, Federico, Gatell, José María, González-García, Juan, Gutiérrez, Félix, Iribarren, José Antonio, Knobel, Hernando, Llibre, Josep María, López-Bernaldo de Quirós, Juan Carlos, López-Cortés, Luis Fernando, Losa, Juan Emilio, Mariño, Ana, Miró, José M., Montes, María L., Moreno, Santiago, Negredo, Eugenia, Pérez-Elías, María J., Podzamczer, Daniel, Portilla, Joaquín, Poveda, Eva, Pulido, Federico, Ribera, Esteban, Rivero, Antonio, Rubio, Rafael, Santos, Jesús, Sanz-Moreno, José, Sanz-Sanz, Jesús, Serrano, Sergio, de la Torre, Javier, Tuset, Montserrat, von Wichman, Miguel A., and Martínez, Esteban

Published
2019
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18. Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Author

Herrera-Hidalgo, Laura, primary, Muñoz, Patricia, additional, Álvarez-Uría, Ana, additional, Alonso-Menchén, David, additional, Luque-Marquez, Rafael, additional, Gutiérrez-Carretero, Encarnación, additional, Fariñas, María Del Carmen, additional, Miró, Jose Maria, additional, Goenaga, Miguel Angel, additional, López-Cortés, Luis Eduardo, additional, Angulo-Lara, Basilio, additional, Boix-Palop, Lucia, additional, de Alarcón, Arístides, additional, Sánchez, Fernando Fernández, additional, de Lomas, José Mª García, additional, Rosas, Gabriel, additional, de la Torre Lima, Javier, additional, Bereciartua, Elena, additional, Vidal, María José Blanco, additional, Blanco, Roberto, additional, Boado, María Victoria, additional, Lázaro, Marta Campaña, additional, Crespo, Alejandro, additional, Carrión, Laura Guio, additional, Del Álamo Martínez de Lagos, Mikel, additional, Ugarte, Gorane Euba, additional, Goikoetxea, Ane Josune, additional, Hierro, Marta Ibarrola, additional, Iruretagoyena, José Ramón, additional, Zuazabal, Josu Irurzun, additional, López-Soria, Leire, additional, Montejo, Miguel, additional, Nieto, Javier, additional, Rodrigo, David, additional, Rodríguez, Regino, additional, Vitoria, Yolanda, additional, Voces, Roberto, additional, López, Mª Victoria García, additional, Georgieva, Radka Ivanova, additional, Ojeda, Guillermo, additional, Bailón, Isabel Rodríguez, additional, Morales, Josefa Ruiz, additional, Rodríguez, Ignacio Álvarez, additional, Galparsoro, Harkaitz Azkune, additional, Boronat, Elisa Berritu, additional, Odriozola, Mª Jesús Bustinduy, additional, del Bosque Martín, Cristina, additional, Echeverría, Tomás, additional, Yarza, Alberto Eizaguirre, additional, Fuentes, Ana, additional, Goenaga, Miguel Ángel, additional, del Río, Muskilda Goyeneche, additional, Bauza, Ángela Granda, additional, Iribarren, José Antonio, additional, Urkola, Xabier Kortajarena, additional, López, José Ignacio Pérez-Moreiras, additional, Jiménez, Ainhoa Rengel, additional, Reviejo, Karlos, additional, Berbejillo, Alberto Sáez, additional, Haza, Elou Sánchez, additional, Alda, Rosa Sebastián, additional, Ruiz, Itziar Solla, additional, Ugartemendia, Irati Unamuno, additional, Anza, Diego Vicente, additional, Benito, Iñaki Villanueva, additional, Arrieta, Mar Zabalo, additional, Carrasco, Rafael, additional, Climent, Vicente, additional, Llamas, Patricio, additional, Merino, Esperanza, additional, Plazas, Joaquín, additional, Reus, Sergio, additional, Bouzas, Alberto, additional, Castelo, Brais, additional, Cuenca, José, additional, Gutiérrez, Laura, additional, Ramos, Lucía, additional, Mayo, María Rodríguez, additional, Serrano, Joaquín Manuel, additional, Regueiro, Dolores Sousa, additional, Martínez, Francisco Javier, additional, del Mar Alonso, Mª, additional, Castro, Beatriz, additional, Melian, Teresa Delgado, additional, Sarabia, Javier Fernández, additional, Rosado, Dácil García, additional, González, Julia González, additional, Lacalzada, Juan, additional, de la Peña, Lissete Lorenzo, additional, Ramírez, Alina Pérez, additional, Arrondo, Pablo Prada, additional, Moreno, Fermín Rodríguez, additional, Ciezar, Antonio Plata, additional, Iglesias, José Mª Reguera, additional, Álvarez, Víctor Asensi, additional, Costas, Carlos, additional, de la Hera, Jesús, additional, Suárez, Jonnathan Fernández, additional, Fraile, Lisardo Iglesias, additional, Arguero, Víctor León, additional, Menéndez, José López, additional, Bajo, Pilar Mencia, additional, Morales, Carlos, additional, Torrico, Alfonso Moreno, additional, Palomo, Carmen, additional, Martínez, Begoña Paya, additional, Esteban, Ángeles Rodríguez, additional, García, Raquel Rodríguez, additional, Asensio, Mauricio Telenti, additional, Almela, Manuel, additional, Ambrosioni, Juan, additional, Azqueta, Manuel, additional, Brunet, Mercè, additional, Bodro, Marta, additional, Cartañá, Ramón, additional, Cuervo, Guillermo, additional, Falces, Carlos, additional, Fernández-Pittol, Mariana J, additional, Fita, Guillermina, additional, Fuster, David, additional, de la Mària, Cristina García, additional, García-Pares, Delia, additional, Hernández-Meneses, Marta, additional, Pérez, Jaume Llopis, additional, Marco, Francesc, additional, Miró, José M., additional, Moreno, Asunción, additional, Nicolás, David, additional, Ninot, Salvador, additional, Quintana, Eduardo, additional, Paré, Carlos, additional, Pereda, Daniel, additional, Pericás, Juan M., additional, Pomar, José L., additional, Ramírez, José, additional, Roque, Mercè, additional, Rovira, Irene, additional, Sandoval, Elena, additional, Sitges, Marta, additional, Soy, Dolors, additional, Téllez, Adrián, additional, Tolosana, José M., additional, Vidal, Bárbara, additional, Vila, Jordi, additional, Adán, Iván, additional, Alonso, David, additional, Alonso, Juan Carlos, additional, Bermejo, Javier, additional, Bouza, Emilio, additional, Caballero, Gregorio Cuerpo, additional, Montero, Antonia Delgado, additional, Estévez, Agustín, additional, Ribas, Ramón Fortuny, additional, Gargallo, Esther, additional, Leoni, Mª Eugenia García, additional, Mansilla, Ana González, additional, Moraga, Francisco Javier González, additional, Ramallo, Víctor González, additional, Hernández, Martha Kestler, additional, Hualde, Amaia Mari, additional, Machado, Marina, additional, Marín, Mercedes, additional, Martínez-Sellés, Manuel, additional, Melero, Rosa, additional, Monzón, Diego, additional, Olmedo, María, additional, Pedraz, Álvaro, additional, Pinilla, Blanca, additional, Pinto, Ángel, additional, Rincón, Cristina, additional, Rodríguez-Abella, Hugo, additional, Rodríguez-Créixems, Marta, additional, Sánchez-Pérez, Eduardo, additional, Segado, Antonio, additional, Toledo, Neera, additional, Valerio, Maricela, additional, Vázquez, Pilar, additional, Moreno, Eduardo Verde, additional, de la Villa, Sofía, additional, Antorrena, Isabel, additional, Loeches, Belén, additional, Moreno, Mar, additional, Ramírez, Ulises, additional, Bastón, Verónica Rial, additional, Romero, María, additional, Rosillo, Sandra, additional, Balbín, Jesús Agüero, additional, Fernández, Cristina Amado, additional, Castillo, Carlos Armiñanzas, additional, de las Revillas, Francisco Arnaiz, additional, Belaustegui, Manuel Cobo, additional, Fariñas, María Carmen, additional, Fariñas-Álvarez, Concepción, additional, Sampedro, Marta Fernández, additional, García, Iván, additional, Rico, Claudia González, additional, Gutiérrez-Fernández, Laura, additional, Gutiérrez-Cuadra, Manuel, additional, Díez, José Gutiérrez, additional, Pajarón, Marcos, additional, Parra, José Antonio, additional, Teira, Ramón, additional, Zarauza, Jesús, additional, Parra, Jorge Calderón, additional, Cobo, Marta, additional, Domínguez, Fernando, additional, Pavía, Pablo García, additional, Cruz, Ana Fernández, additional, Ramos-Martínez, Antonio, additional, Romero, Isabel Sánchez, additional, Centella, Tomasa, additional, Hermida, José Manuel, additional, Moya, José Luis, additional, Martín-Dávila, Pilar, additional, Navas, Enrique, additional, Oliva, Enrique, additional, del Río, Alejandro, additional, Stuart, Jorge Rodríguez-Roda, additional, Ruiz, Soledad, additional, Tenorio, Carmen Hidalgo, additional, Sequera, Sergio, additional, Delia, Manuel Almendro, additional, Araji, Omar, additional, Barquero, José Miguel, additional, Jambrina, Román Calvo, additional, de Cueto, Marina, additional, Acebal, Juan Gálvez, additional, Méndez, Irene, additional, Morales, Isabel, additional, Lepe, José Antonio, additional, López-Haldón, José, additional, Luque-Márquez, Rafael, additional, Marín, Guillermo, additional, Ortiz-Carrellán, Antonio, additional, Sánchez-Domínguez, Eladio, additional, Alonso, Luis Javier, additional, Azcárate, Pedro, additional, Gutiérrez, José Manuel Azcona, additional, Blanco, José Ramón, additional, Armas, Estíbaliz Corral, additional, García-Álvarez, Lara, additional, Oteo, José Antonio, additional, Membrilla, Antonio Barros, additional, Iglesias, Antonino Ginel, additional, Grillo, Sara, additional, Petracca, Rubén Leta, additional, López-Contreras, Joaquín, additional, Martínez, María Alba Rivera, additional, Álvarez, M., additional, Fernández, A.L., additional, Martínez, Amparo, additional, Prieto, A., additional, Regueiro, Benito, additional, Tijeira, E., additional, Vega, Marino, additional, Quiñonero, Amaia Aguirre, additional, Miñambres, Ángela Alonso, additional, Arana, Juan Carlos Gainzarain, additional, de Alaiza Ortega, Sara González, additional, Rodríguez, Miguel Ángel Morán, additional, Rodríguez, Anai Moreno, additional, de Zárate, Zuriñe Ortiz, additional, Zapirain, José Joaquín Portu, additional, de Adana Arroniz, Ester Sáez, additional, Sánchez, Daisy Carolina Sorto, additional, Antonio, Sánchez-Porto, additional, Alejandro, Úbeda Iglesias, additional, Leal, José Mª Arribas, additional, Vázquez, Elisa García, additional, Torres, Alicia Hernández, additional, Blázquez, Ana, additional, de la Morena Valenzuela, Gonzalo, additional, Alonso, Ángel, additional, Aramburu, Javier, additional, Calvo, Felicitas Elena, additional, Tarabini-Castellani, Paola, additional, Gálvez, Eva Heredero, additional, Bellido, Carolina Maicas, additional, Pau, José Largo, additional, Sepúlveda, Mª Antonia, additional, Sierra, Pilar Toledano, additional, Iqbal-Mirza, Sadaf Zafar, additional, Alcolea, Eva Cascales, additional, Yañez, Ivan Keituqwa, additional, Martínez, Julián Navarro, additional, Ballesta, Ana Peláez, additional, Escobar, Eduardo Moreno, additional, Monje, Alejandro Peña, additional, Cabrera, Valme Sánchez, additional, García, David Vinuesa, additional, Asenjo, María Arrizabalaga, additional, Luna, Carmen Cifuentes, additional, Morcillo, Juana Núñez, additional, Seco, Mª Cruz Pérez, additional, Gelabert, Aroa Villoslada, additional, Guallar, Carmen Aured, additional, Abad, Nuria Fernández, additional, Mangas, Pilar García, additional, Adell, Marta Matamala, additional, Ruiz, Mª Pilar Palacián, additional, Porres, Juan Carlos, additional, Vidal, Begoña Alcaraz, additional, Del Amor Espín, María Jesús, additional, Buendía, Francisco, additional, Sánchez, Roberto Jiménez, additional, Mármol, Rosario, additional, Martínez, Francisco, additional, Meseguer, Antonio, additional, Pérez, Beatriz, additional, Risco, Leticia, additional, Saura, Zoser, additional, Silva, Vanina, additional, Villmarín, Mª Belén, additional, Blanco, Mª Ángels Ribas, additional, de Gopegui Bordes, Enrique Ruiz, additional, Bonet, Laura Vidal, additional, Borràs, Miquel Vives, additional, Munera, Mª Carmen Bellón, additional, Garaizabal, Elena Escribano, additional, Martínez, Antonia Tercero, additional, Luque, Juan Carlos Segura, additional, Badía, Cristina, additional, Palop, Lucía Boix, additional, Xercavins, Mariona, additional, Ibars, Sónia, additional, Bosch, Xerach, additional, Nebreda, Eloy Gómez, additional, Herrera, Ibalia Horcajada, additional, Gallego, Irene Menduiña, additional, Pulido, Imanol, additional, Santiago, Héctor Marrero, additional, de Miguel Martínez, Isabel, additional, Álamo, Elena Pisos, additional, Sánchez, Daniel San Román, additional, Pérez, Jorge Boan, additional, Blanco, Eva Mª Aguilar, additional, González, Mercedes Catalán, additional, Peiretti, María Angélica Corres, additional, Esteve, Andrea Eixerés, additional, Pérez, Laura Domínguez, additional, de Cossío Tejido, Santiago, additional, Román, Francisco Galván, additional, Robles, José Antonio García, additional, Medrano, Francisco López, additional, Gude, Mª Jesús López, additional, Miguel, Mª Ángeles Orellana, additional, Pilkington, Patrick, additional, Ostalaza, Yolanda Revilla, additional, Morales, Juan Ruiz, additional, Solís, Sebastián Ruiz, additional, Collado, Ana Sabín, additional, Fernández, Marcos Sánchez, additional, Rallo, Javier Solera, additional, Martín, Jorge Solís, additional, Escrihuela-Vidal, Francesc, additional, Carratalà, Jordi, additional, Grau, Inmaculada, additional, Ardanuy, Carmen, additional, Berbel, Dámaris, additional, Salado, José Carlos Sánchez, additional, Alegre, Oriol, additional, Majoral, Alejandro Ruiz, additional, Sbraga, Fabrizio, additional, Blasco, Arnau, additional, Sánchez, Laura Gracia, additional, Sánchez-Rodríguez, Iván, additional, Aldamiz, Gonzalo, additional, Álvarez, Beatriz, additional, Palacios, Marina Bernal, additional, Úbeda, Alfonso Cabello, additional, Roblas, Ricardo Fernández, additional, Hernández, Rafael, additional, Martín, Victoria Andrea Hortigüela, additional, Kallmeyer, Andrea, additional, Kancev, Cristina Landaeta, additional, Martín, Marta, additional, Ruiz, Miguel Morante, additional, Lobato, Miguel Ángel Navas, additional, Pello, Ana María, additional, Prieto, Laura, additional, Mallebrera, Marta Tomás, additional, Varela, Laura, additional, de la Peña Triguero, Mireia, additional, Cerón, Ruth Esther Figueroa, additional, Gómez, Lara Ruiz, additional, Ble, Mireia, additional, Gallego, Juan Pablo Horcajada, additional, Ginel, Antonio José, additional, López, Inmaculada, additional, Mas, Alexandra, additional, Mestres, Antoni, additional, Molina, Lluís, additional, Serrat, Ramón, additional, Ribas, Núria, additional, Sánchez, Francisca, additional, Silverio, Ana, additional, Suárez, Marina, additional, Sorlí, Luisa, additional, Recasens, Lluís, additional, Taurón, Manuel, additional, Regueras, María Fernández, additional, Vallejo, María Ángeles Mantecón, additional, Rivera, José Ángel Pérez, additional, Mata, Nuria Sánchez, additional, Cano, Antonia Calvo, additional, Olivares, Miguel Fajardo, additional, Núñez, María Victoria Millán, additional, and Sanz, Agustín Muñoz, additional

Published
2023
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19. Life expectancy of people with HIV on antiretroviral therapy in Spain

Author

Jarrín, Inma, primary, Rava, Marta, additional, Raposo, Jorge Del Romero, additional, Rivero, Antonio, additional, Del Romero Guerrero, Jorge, additional, De Lagarde, María, additional, Martínez Sanz, Javier, additional, Navarro, Gemma, additional, Dalmau, David, additional, Blanco, José Ramón, additional, Koerting, Ana, additional, Gomez Castell, Javier, additional, and Del Amo, Julia, additional

Published
2023
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20. Gentamicin may have no effect on mortality of staphylococcal prosthetic valve endocarditis

Author

Sánchez, Fernando Fernández, Noureddine, Mariam, Rosas, Gabriel, Lima, Javier de la Torre, Aramendi, José, Bereciartua, Elena, Blanco, Roberto, Boado, María Victoria, Estébanez, Itxasne Cabezón, Lázaro, Marta Campaña, Goikoetxea, Josune, Goiti, Juan José, Iruretagoyena, José Ramón, Zuazabal, Josu Irurzun, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodríguez, David, Rodríguez, Regino, Voces, Roberto, López, M<ce:sup loc='post">a</ce:sup> Victoria García, Georgieva, Radka Ivanova, Ojeda, Guillermo, Bailón, Isabel Rodríguez, Morales, Josefa Ruiz, Cuende, Ana María, Echeverría, Tomás, Fuerte, Ana, Gaminde, Eduardo, Goenaga, Miguel Ángel, Idígoras, Pedro, Iribarren, José Antonio, Yarza, Alberto Izaguirre, Urkola, Xabier Kortajarena, Reviejo, Carlos, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Rey, Enrique Miguez, Mayo, María Rodríguez, Sánchez, Efrén, Regueiro, Dolores Sousa, Martínez, Francisco Javier, del Mar Alonso, M<ce:sup loc='post">a</ce:sup>, Castro, Beatriz, Rosado, Dácil García, del Carmen Durán, M<ce:sup loc='post">a</ce:sup>, Antonia Miguel Gómez, M<ce:sup loc='post">a</ce:sup>, Lacalzada, Juan, Nassar, Ibrahim, Ciezar, Antonio Plata, Reguera Iglesias, José M<ce:sup loc='post">a</ce:sup>, Álvarez, Víctor Asensi, Costas, Carlos, Hera, Jesús de la, Suárez, Jonnathan Fernández, Fraile, Lisardo Iglesias, Arguero, Víctor León, Menéndez, José López, Bajo, Pilar Mencia, Morales, Carlos, Torrico, Alfonso Moreno, Palomo, Carmen, Martínez, Begoña Paya, Esteban, Ángeles Rodríguez, García, Raquel Rodríguez, Asensio, Mauricio Telenti, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Falces, Carlos, Fita, Guillermina, Fuster, David, García de la Mària, Cristina, Hernández-Meneses, Marta, Pérez, Jaume Llopis, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Bermejo, Javier, Bouza, Emilio, Caballero, Gregorio Cuerpo, Cruz, Ana Fernández, García Leoni, M<ce:sup loc='post">a</ce:sup> Eugenia, Ramallo, Víctor González, Hernández, Martha Kestler, Marín, Mercedes, Martínez-Sellés, Manuel, Menárguez, M<ce:sup loc='post">a</ce:sup> Cruz, Muñoz, Patricia, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Pinilla, Blanca, Pinto, Ángel, Valerio, Maricela, Vázquez, Pilar, Moreno, Eduardo Verde, Antorrena, Isabel, Loeches, Belén, Quirós, Alejandro Martín, Moreno, Mar, Ramírez, Ulises, Bastón, Verónica Rial, Romero, María, Saldaña, Araceli, Balbín, Jesús Agüero, Castillo, Carlos Armiñanzas, Arnaiz, Ana, Arnaiz de las Revillas, Francisco, Belaustegui, Manuel Cobo, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Izquierdo, Rubén Gómez, García, Iván, Rico, Claudia González, Gutiérrez-Cuadra, Manuel, Díez, José Gutiérrez, Pajarón, Marcos, Parra, José Antonio, Teira, Ramón, Zarauza, Jesús, Domínguez, Fernando, Pavíaz, Pablo García, Gonzálezz, Jesús, Ordenz, Beatriz, Ramosz, Antonio, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, Río, Alejandro del, Ruiz, Soledad, Tenorio, Carmen Hidalgo, Delia, Manuel Almendro, Araji, Omar, Barquero, José Miguel, Jambrina, Román Calvo, de Cueto, Marina, Acebal, Juan Gálvez, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, de Alarcón, Arístides, García, Emilio, Haro, Juan Luis, Lepe, José Antonio, López, Francisco, Luque, Rafael, Alonso, Luis Javier, Azcárate, Pedro, Azcona Gutiérrez, José Manuel, Blanco, José Ramón, García-Álvarez, Lara, Oteo, José Antonio, Sanz, Mercedes, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Álvarez, M., Fernández, A.L., Martínez, Amparo, Prieto, A., Regueiro, Benito, Tijeira, E., Vega, Marino, Blasco, Andrés Canut, Mollar, José Cordo, Gainzarain Arana, Juan Carlos, Uriarte, Oscar García, López, Alejandro Martín, Ortiz de Zárate, Zuriñe, Urturi Matos, José Antonio, Domínguez, Gloria García, Sánchez-Porto, Antonio, Arribas Leal, José M<ce:sup loc='post">a</ce:sup>, Vázquez, Elisa García, Torres, Alicia Hernández, Blázquez, Ana, Valenzuela, Gonzalo de la Morena, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Rodríguez, Anai Moreno, Tarabini-Castellani, Paola, Gálvez, Eva Heredero, Bellido, Carolina Maicas, Pau, José Largo, Sepúlveda, M<ce:sup loc='post">a</ce:sup> Antonia, Sierra, Pilar Toledano, Iqbal-Mirza, Sadaf Zafar, Alcolea, Eva Cascales, Serrano, Pilar Egea, Hernández Roca, José Joaquín, Yañez, Ivan Keituqwa, Ballesta, Ana Peláez, Soriano, Víctor, Escobar, Eduardo Moreno, Monje, Alejandro Peña, Cabrera, Valme Sánchez, García, David Vinuesa, Asenjo, María Arrizabalaga, Luna, Carmen Cifuentes, Morcillo, Juana Núñez, Pérez Seco, M<ce:sup loc='post">a</ce:sup> Cruz, Gelabert, Aroa Villoslada, Guallar, Carmen Aured, Abad, Nuria Fernández, Mangas, Pilar García, Adell, Marta Matamala, Palacián Ruiz, Ma Pilar, Porres, Juan Carlos, Ramos-Martínez, Antonio, Muñoz Serrano, Alejandro, de Alarcón González, Arístides, Fernández-Cruz, Ana, Miró, José M<ce:sup loc='post">a</ce:sup>, Ruiz-Morales, Josefa, Sousa-Regueiro, Dolores, Montejo, José Miguel, Gálvez-Acebal, Juan, and HidalgoTenorio, Carmen

Published
2018
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21. Infective Endocarditis in Patients With Bicuspid Aortic Valve or Mitral Valve Prolapse

Author

Fernández Sánchez, Fernando, Noureddine, Mariam, Rosas, Gabriel, de la Torre Lima, Javier, Aramendi, José, Bereciartua, Elena, Blanco, María José, Blanco, Roberto, Boado, María Victoria, Campaña Lázaro, Marta, Crespo, Alejandro, Goikoetxea, Josune, Iruretagoyena, José Ramón, Irurzun Zuazabal, Josu, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, García López, María Victoria, Ivanova Georgieva, Radka, Ojeda, Guillermo, Rodríguez Bailón, Isabel, Ruiz Morales, Josefa, Cuende, Ana María, Echeverría, Tomás, Fuerte, Ana, Gaminde, Eduardo, Goenaga, Miguel Ángel, Idígoras, Pedro, Iribarren, José Antonio, Izaguirre Yarza, Alberto, Kortajarena Urkola, Xabier, Reviejo, Carlos, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Miguez Rey, Enrique, Rodríguez Mayo, María, Sánchez, Efrén, Sousa Regueiro, Dolores, Martínez, Francisco Javier, Alonso, María del Mar, Castro, Beatriz, García Rosado, Dácil, Durán, Mª del Carmen, Miguel Gómez, Mª Antonia, Lacalzada, Juan, Nassar, Ibrahim, Plata Ciezar, Antonio, Reguera Iglesias, José Mª, Asensi Álvarez, Víctor, Costas, Carlos, de la Hera, Jesús, Fernández Suárez, Jonnathan, Iglesias Fraile, Lisardo, León Arguero, Víctor, López Menéndez, José, Mencia Bajo, Pilar, Morales, Carlos, Moreno Torrico, Alfonso, Palomo, Carmen, Paya Martínez, Begoña, Rodríguez Esteban, Ángeles, Rodríguez García, Raquel, Telenti Asensio, Mauricio, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Falces, Carlos, Fita, Guillermina, Fuster, David, García de la Mària, Cristina, Hernández-Meneses, Marta, Llopis Pérez, Jaume, Marco, Francesc, Miró, José María, Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan Manuel, Pomar, José Luis, Ramírez, José, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Bermejo, Javier, Bouza, Emilio, Celemín, Daniel, Cuerpo Caballero, Gregorio, Delgado Montero, Antonia, Fernández Cruz, Ana, García Mansilla, Ana, García Leoni, María Eugenia, González Ramallo, Víctor, Kestler Hernández, Martha, Hualde, Amaia Mari, Marín, Mercedes, Martínez-Sellés, Manuel, Menárguez, María Cruz, Muñoz, Patricia, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Pinilla, Blanca, Pinto, Ángel, Valerio, Maricela, Vázquez, Pilar, Verde Moreno, Eduardo, Antorrena, Isabel, Loeches, Belén, Martín Quirós, Alejandro, Moreno, Mar, Ramírez, Ulises, Rial Bastón, Verónica, Romero, María, Saldaña, Araceli, Agüero Balbín, Jesús, Armiñanzas Castillo, Carlos, Arnaiz, Ana, Arnaiz de las Revillas, Francisco, Cobo Belaustegui, Manuel, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Gómez Izquierdo, Rubén, García, Iván, González Rico, Claudia, Gutiérrez-Cuadra, Manuel, Gutiérrez Díez, José, Pajarón, Marcos, Parra, José Antonio, Teira, Ramón, Zarauza, Jesús, Domínguez, Fernando, García-Pavía, Pablo, Mirelis, Jesús González, Orden, Beatriz, Ramos, Antonio, Cobo-Marcos, Marta, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, del Río, Alejandro, Ruiz, Soledad, Hidalgo Tenorio, Carmen, Almendro Delia, Manuel, Araji, Omar, Barquero, José Miguel, Calvo Jambrina, Román, de Cueto, Marina, Gálvez Acebal, Juan, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, de Alarcón, Arístides, García, Emilio, Haro, Juan Luis, Lepe, José Antonio, López, Francisco, Luque, Rafael, Alonso, Luis Javier, Azcárate, Pedro, Azcona Gutiérrez, José Manuel, Blanco, José Ramón, García-Álvarez, Lara, Oteo, José Antonio, Sanz, Mercedes, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Fernández, Ángel Luis, Martínez, Amparo, Prieto, Arturo, Regueiro, Benito, Vega, Marino, Blasco, Andrés Canut, Mollar, José Cordo, Gainzarain Arana, Juan Carlos, García Uriarte, Oscar, Martín López, Alejandro, Ortiz de Zárate, Zuriñe, Urturi Matos, José Antonio, García Domínguez, Gloria, Sánchez-Porto, Antonio, Arribas Leal, José Mª, García Vázquez, Elisa, Hernández Torres, Alicia, Blázquez, Ana, de la Morena Valenzuela, Gonzalo, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Moreno Rodríguez, Anai, Tarabini-Castellani, Paola, Heredero Gálvez, Eva, Maicas Bellido, Carolina, Largo Pau, José, Sepúlveda, María Antonia, Toledano Sierra, Pilar, Iqbal-Mirza, Sadaf Zafar, Cascales Alcolea, Eva, Egea Serrano, Pilar, Hernández Roca, José Joaquín, Keituqwa Yañez, Ivan, Peláez Ballesta, Ana, Soriano, Víctor, Moreno Escobar, Eduardo, Peña Monje, Alejandro, Sánchez Cabrera, Valme, Vinuesa García, David, Arrizabalaga Asenjo, María, Cifuentes Luna, Carmen, Núñez Morcillo, Juana, Pérez Seco, Mª Cruz, Villoslada Gelabert, Aroa, Aured Guallar, Carmen, Fernández Abad, Nuria, García Mangas, Pilar, Matamala Adell, Marta, Palacián Ruiz, Mª Pilar, Porres, Juan Carlos, Alcaraz Vidal, Begoña, Cobos Trigueros, Nazaret, Del Amor Espín, María Jesús, Giner Caro, José Antonio, Jiménez Sánchez, Roberto, Jimeno Almazán, Amaya, Ortín Freire, Alejandro, Viqueira González, Monserrat, Pericás Ramis, Pere, Ribas Blanco, Mª Ángels, Ruiz de Gopegui Bordes, Enrique, Vidal Bonet, Laura, Bellón Munera, Mª Carmen, Escribano Garaizabal, Elena, Tercero Martínez, Antonia, Segura Luque, Juan Carlos, Zegri-Reiriz, Isabel, Martínez Sellés, Manuel, González-Ramallo, Victor, Miro, Jose M., Falces, Carles, Gonzalez Rico, Claudia, Rodriguez Alvarez, Regino, Reguera Iglesias, Jose Maria, Dominguez, Fernando, and Garcia-Pavia, Pablo

Published
2018
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23. Thymic Function Failure Is Associated With Human Immunodeficiency Virus Disease Progression

Author

Ferrando-Martinez, Sara, De Pablo-Bernal, Rebeca S., De Luna-Romero, Marta, De Ory, Santiago J., Genebat, Miguel, Pacheco, Yolanda M., Parras, Francisco J., Montero, Marta, Blanco, Jose Ramón, Gutierrez, Felix, Santos, Jesus, Vidal, Francisco, Koup, Richard A., Muñoz-Fernández, María Ángeles, Leal, Manuel, and Ruiz-Mateos, Ezequiel

Published
2017

31. The circadian rhythm of viruses and its implications on susceptibility to infection

Author

Blanco, José Ramón, Verdugo-Sivianes, Eva M., Amiama-Roig, Ana, Muñoz-Galván, Sandra, Blanco, José Ramón, Verdugo-Sivianes, Eva M., Amiama-Roig, Ana, and Muñoz-Galván, Sandra

Abstract

Circadian genes have an impact on multiple hormonal, metabolic, and immunological pathways and have recently been implicated in some infectious diseases.

Published
2022

32. Senotherapeutics in Cancer and HIV

Author

Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Centro de Investigación Biomédica en Red Cáncer (España), Junta de Andalucía, Fundación Eugenio Rodríguez Pascual, Fundación Científica Asociación Española Contra el Cáncer, Sánchez-Díaz, Laura, Espinosa-Sánchez, Asunción, Blanco, José Ramón, Carnero, Amancio, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Centro de Investigación Biomédica en Red Cáncer (España), Junta de Andalucía, Fundación Eugenio Rodríguez Pascual, Fundación Científica Asociación Española Contra el Cáncer, Sánchez-Díaz, Laura, Espinosa-Sánchez, Asunción, Blanco, José Ramón, and Carnero, Amancio

Abstract

Cellular senescence is a stress-response mechanism that contributes to homeostasis maintenance, playing a beneficial role during embryogenesis and in normal adult organisms. In contrast, chronic senescence activation may be responsible for other events such as age-related disorders, HIV and cancer development. Cellular senescence activation can be triggered by different insults. Regardless of the inducer, there are several phenotypes generally shared among senescent cells: cell division arrest, an aberrant shape, increased size, high granularity because of increased numbers of lysosomes and vacuoles, apoptosis resistance, defective metabolism and some chromatin alterations. Senescent cells constitute an important area for research due to their contributions to the pathogenesis of different diseases such as frailty, sarcopenia and aging-related diseases, including cancer and HIV infection, which show an accelerated aging. Hence, a new pharmacological category of treatments called senotherapeutics is under development. This group includes senolytic drugs that selectively attack senescent cells and senostatic drugs that suppress SASP factor delivery, inhibiting senescent cell development. These new drugs can have positive therapeutic effects on aging-related disorders and act in cancer as antitumor drugs, avoiding the undesired effects of senescent cells such as those from SASP. Here, we review senotherapeutics and how they might affect cancer and HIV disease, two very different aging-related diseases, and review some compounds acting as senolytics in clinical trials.

Published
2022

37. Role of Maraviroc and/or Rapamycin in Aging Liver Processes

Author

Pérez-Martínez, Laura, primary, Romero, Lourdes, additional, Verdugo-Sivianes, Eva M., additional, Muñoz-Galván, Sandra, additional, Rubio-Mediavilla, Susana, additional, Amiama, Ana, additional, Carnero, Amancio, additional, and Blanco, José Ramón, additional

Published
2022
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39. Similar CD4/CD8 Ratio Recovery After Initiation of Dolutegravir Plus Lamivudine Versus Dolutegravir or Bictegravir-Based Three-Drug Regimens in Naive Adults With HIV

Author

Martínez-Sanz, Javier, primary, Ron, Raquel, additional, Moreno, Elena, additional, Sánchez-Conde, Matilde, additional, Muriel, Alfonso, additional, López Cortés, Luis Fernando, additional, Blanco, José Ramón, additional, Pineda, Juan Antonio, additional, Mena, Álvaro, additional, Calzado Isbert, Sonia, additional, Moreno, Santiago, additional, and Serrano-Villar, Sergio, additional

Published
2022
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40. DOLAVI Real-Life Study of Dolutegravir Plus Lamivudine in Naive HIV-1 Patients (48 Weeks)

Author

Hidalgo-Tenorio, Carmen, primary, Pasquau, Juan, additional, Vinuesa, David, additional, Ferra, Sergio, additional, Terrón, Alberto, additional, SanJoaquín, Isabel, additional, Payeras, Antoni, additional, Martínez, Onofre Juan, additional, López-Ruz, Miguel Ángel, additional, Omar, Mohamed, additional, de la Torre-Lima, Javier, additional, López-Lirola, Ana, additional, Palomares, Jesús, additional, Blanco, José Ramón, additional, Montero, Marta, additional, and García-Vallecillos, Coral, additional

Published
2022
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42. Mural Endocarditis: The GAMES Registry Series and Review of the Literature

Author

Gutiérrez-Villanueva, Andrea, Muñoz, Patricia, Delgado-Montero, Antonia, Olmedo-Samperio, María, de Alarcón, Arístides, Gutiérrez-Carretero, Encarnación, Zarauza, Jesús, García i Pares, Delia, Goenaga, Miguel Ángel, Ojeda-Burgos, Guillermo, Goikoetxea-Agirre, Ane Josune, Reguera-Iglesias, José Mª, Ramos, Antonio, Fernández-Cruz, Ana, Fernández-Sánchez, Fernando, García de Lomas, José Mª, Rosas, Gabriel, de la Torre Lima, Javier, Bereciartua, Elena, Blanco-Vidal, María José, Blanco, Roberto, Boado, María Victoria, Campaña-Lázaro, Marta, Crespo, Alejandro, Guio-Carrión, Laura, del Álamo Martínez-Lagos, Mikel, Euba-Ugarte, Gorane, Goikoetxea, Ane Josune, Ibarrola-Hierro, Marta, Iruretagoyena, José Ramón, Irurzun-Zuazabal, Josu, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, García-López, Mª Victoria, Georgieva, Radka Ivanova, Ojeda, Guillermo, Rodríguez-Bailón, Isabel, Ruiz-Morales, Josefa, Azkune-Galparsoro, Harkaitz, Berritu-Boronat, Elisa, Bustinduy-Odriozola, Mª Jesús, del Bosque Martín, Cristina, Echeverría, Tomás, Eizaguirre-Yarza, Alberto, Fuentes, Ana, Goyeneche del Río, Muskilda, Granda-Bauza, Ángela, Iribarren, José Antonio, Kortajarena-Urkola, Xabier, Pérez-Moreiras López, José Ignacio, Rengel-Jiménez, Ainhoa, Reviejo, Karlos, Sáez-Berbejillo, Alberto, Sánchez-Haza, Elou, Sebastián-Alda, Rosa, Solla-Ruiz, Itziar, Unamuno-Ugartemendia, Irati, Anza, Diego Vicente, Villanueva-Benito, Iñaki, Zabalo-Arrieta, Mar, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Miguez-Rey, Enrique, Rodríguez-Mayo, María, Sánchez, Efrén, Sousa-Regueiro, Dolores, Martínez, Francisco Javier, del Mar Alonso, null, Castro, Beatriz, Delgado-Melian, Teresa, Fernández-Sarabia, Javier, García-Rosado, Dácil, González-González, Julia, Lacalzada, Juan, Lorenzo de la Peña, Lissete, Pérez-Ramírez, Alina, Prada-Arrondo, Pablo, Rodríguez-Moreno, Fermín, Plata-Ciezar, Antonio, Asensi-Álvarez, Víctor, Costas, Carlos, de la Hera, Jesús, Fernández-Suárez, Jonnathan, Iglesias-Fraile, Lisardo, León-Arguero, Víctor, López-Menéndez, José, Mencia-Bajo, Pilar, Morales, Carlos, Moreno-Torrico, Alfonso, Palomo, Carmen, Paya-Martínez, Begoña, Rodríguez-Esteban, Ángeles, Rodríguez-García, Raquel, Telenti-Asensio, Mauricio, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Falces, Carlos, Fita, Guillermina, Fuster, David, García de la Mària, Cristina, Hernández-Meneses, Marta, Llopis-Pérez, Jaume, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Alonso, Juan Carlos, Álvarez-Uría, Ana, Bermejo, Javier, Bouza, Emilio, Cuerpo-Caballero, Gregorio, González-Mansilla, Ana, García-Leoni, Mª Eugenia, Gargallo, Esther, González-Ramallo, Víctor, Kestler-Hernández, Martha, Hualde, Amaia Mari, Machado, Marina, Marín, Mercedes, Martínez-Sellés, Manuel, Olmedo, María, Pedraz, Álvaro, Pinilla, Blanca, Pinto, Ángel, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Segado, Antonio, Toledo, Neera, Valerio, Maricela, Vázquez, Pilar, Verde-Moreno, Eduardo, Antorrena, Isabel, Loeches, Belén, Moreno, Mar, Ramírez, Ulises, Rial-Bastón, Verónica, Romero, María, Rosillo, Sandra, Agüero-Balbín, Jesús, Amado, Cristina, Armiñanzas-Castillo, Carlos, Arnaiz, Ana, Arnaiz de las Revillas, Francisco, Cobo Belaustegui, Manuel, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Fernández-Sampedro, Marta, García, Iván, González-Rico, Claudia, Gutierrez-Fernandez, Laura, Gutiérrez-Cuadra, Manuel, Gutiérrez-Díez, José, Pajarón, Marcos, Parra, José Antonio, Teira, Ramón, Calderón-Parra, Jorge, Cobo, Marta, Domínguez, Fernando, García-Pavía, Pablo, Ramos-Martínez, Antonio, Sánchez-Romero, Isabel, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, del Río, Alejandro, Rodríguez-Roda Stuart, Jorge, Ruiz, Soledad, Hidalgo-Tenorio, Carmen, Almendro-Delia, Manuel, Araji, Omar, Barquero, José Miguel, Calvo-Jambrina, Román, de Cueto, Marina, Gálvez-Acebal, Juan, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, Lepe, José Antonio, López-Haldón, José, Luque-Márquez, Rafael, Marín, Guillermo, Ortiz-Carrellán, Antonio, Sánchez-Domínguez, Eladio, Alonso, Luis Javier, Azcárate, Pedro, Azcona-Gutiérrez, José Manuel, Blanco, José Ramón, Cabrera-Villegas, Antonio, García-Álvarez, Lara, García-García, Concepción, Oteo, José Antonio, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Álvarez, null, Fernández, null, Martínez, Amparo, Prieto, null, Regueiro, Benito, Tijeira, null, Vega, Marino, Canut-Blasco, Andrés, Mollar, José Cordo, Gainzarain-Arana, Juan Carlos, García-Uriarte, Oscar, Martín-López, Alejandro, Ortiz de Zárate, Zuriñe, Urturi-Matos, José Antonio, Sánchez-Porto, Antonio, Úbeda-Iglesias, Alejandro, Arribas-Leal, José Mª, García-Vázquez, Elisa, Hernández-Torres, Alicia, Blázquez, Ana, de la Morena Valenzuela, Gonzalo, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Moreno-Rodríguez, Anai, Tarabini-Castellani, Paola, Heredero-Gálvez, Eva, Maicas-Bellido, Carolina, Largo-Pau, José, Sepúlveda, Mª Antonia, Toledano-Sierra, Pilar, Iqbal-Mirza, Sadaf Zafar, Cascales-Alcolea, Eva, Keituqwa-Yañez, Ivan, Navarro-Martínez, Julián, Peláez-Ballesta, Ana, Moreno-Escobar, Eduardo, Peña-Monje, Alejandro, Sánchez-Cabrera, Valme, Vinuesa-García, David, Arrizabalaga-Asenjo, María, Cifuentes-Luna, Carmen, Núñez-Morcillo, Juana, Pérez-Seco, Mª Cruz, Villoslada-Gelabert, Aroa, Aured-Guallar, Carmen, Fernández-Abad, Nuria, García-Mangas, Pilar, Matamala-Adell, Marta, Palacián-Ruiz, Mª Pilar, Porres, Juan Carlos, Alcaraz-Vidal, Begoña, Cobos-Trigueros, Nazaret, Del Amor Espín, María Jesús, Giner-Caro, José Antonio, Jiménez-Sánchez, Roberto, Jimeno-Almazán, Amaya, Ortín-Freire, Alejandro, Viqueira-González, Monserrat, Pericás-Ramis, Pere, Ribas-Blanco, Mª Ángels, Ruiz de Gopegui Bordes, Enrique, Vidal-Bonet, Laura, Bellón-Munera, Mª Carmen, Escribano-Garaizabal, Elena, Tercero-Martínez, Antonia, Segura-Luque, Juan Carlos, Badía, Cristina, Boix-Palop, Lucía, Xercavins, Mariona, Ibars, Sónia, Bosch, Xerach, Gómez-Nebreda, Eloy, Horcajada-Herrera, Ibalia, Menduiña-Gallego, Irene, Pulido, Imanol, Marrero-Santiago, Héctor, de Miguel Martínez, Isabel, Pisos-Álamo, Elena, Aguilar-Blanco, Eva Mª, Catalán-González, Mercedes, Corres-Peiretti, María Angélica, Eixerés-Esteve, Andrea, Domínguez-Pérez, Laura, de Cossío Tejido, Santiago, Galván-Román, Francisco, García-Robles, José Antonio, López-Medrano, Francisco, López-Gude, Mª Jesús, Orellana-Miguel, Mª Ángeles, Pilkington, Patrick, Revilla-Ostalaza, Yolanda, Morales, Juan Ruiz, Ruiz-Solís, Sebastián, Collado, Ana Sabín, Sánchez-Fernández, Marcos, Rallo, Javier Solera, Martín, Jorge Solís, Cuervo, Guillermo, Escrihuela-Vidal, Francesc, Carratalà, Jordi, Grau, Inmaculada, Grillo, Sara, Ardanuy, Carmen, Berbel, Dámaris, Sánchez-Salado, José Carlos, Alegre, Oriol, Ruiz-Majoral, Alejandro, Sbraga, Fabrizio, Blasco, Arnau, Sánchez, Laura Gracia, Sánchez-Rodríguez, Iván, Álvarez, Beatriz, Cabello-Úbeda, Alfonso, Fernández-Roblas, Ricardo, Navas-Lobato, Miguel Ángel, Pello, Ana María, de la Peña Triguero, Mireia, Figueroa-Cerón, Ruth Esther, Ruiz-Gómez, Lara, Ble, Mireia, Horcajada-Gallego, Juan Pablo, Ginel, Antonio José, López, Inmaculada, Mas, Alexandra, Mestres, Antoni, Molina, Lluís, Serrat, Ramón, Ribas, Núria, Sánchez, Francisca, Silverio, Ana, Suárez, Marina, Sorlí, Luisa, Recasens, Lluís, Taurón, Manuel, 0000-0003-1189-1120, and Universidad de Cantabria

Subjects
Microbiology (medical), medicine.medical_specialty, medicine.medical_treatment, Charlson index, Infections, Hospital patients, Mural, Internal medicine, medicine, Endocarditis, Malalts hospitalitzats, business.industry, Brief Report, medicine.disease, Infeccions, Transplantation, Catheter, Non-valvular endocarditis, Infectious Diseases, Infective endocarditis, Etiology, Hemodialysis, Complication, business, human activities
Abstract

Spanish Collaboration on Endocarditis—Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES)., [Introduction] Mural infective endocarditis (MIE) is a rare type of endovascular infection. We present a comprehensive series of patients with mural endocarditis., [Methods] Patients with infectious endocarditis (IE) from 35 Spanish hospitals were prospectively included in the GAMES registry between 2008 and 2017. MIEs were compared to non-MIEs. We also performed a literature search for cases of MIE published between 1979 and 2019 and compared them to the GAMEs series., [Results] Twenty-seven MIEs out of 3676 IEs were included. When compared to valvular IE (VIE) or device-associated IE (DIE), patients with MIE were younger (median age 59 years, p, [Conclusion] MIE is a rare entity. It is often a complication of catheter use, particularly in immunocompromised and hemodialysis patients. Fungal etiology is common. Mortality is similar to other IEs.

Published
2021

44. Implications of maraviroc and/or rapamycin in a mouse model of fragility

Author

Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Pérez-Martínez, Laura, Romero, Lourdes, Muñoz-Galván, Sandra, Verdugo-Sivianes, Eva M., Rubio-Mediavilla, Susana, Oteo, José Antonio, Carnero, Amancio, Blanco, José Ramón, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Pérez-Martínez, Laura, Romero, Lourdes, Muñoz-Galván, Sandra, Verdugo-Sivianes, Eva M., Rubio-Mediavilla, Susana, Oteo, José Antonio, Carnero, Amancio, and Blanco, José Ramón

Abstract

[Background] As age increases, the risk of developing fragility also increases. Improving the knowledge of frailty could contribute to maintaining the functional ability of elderly people. Interleukin (IL)-10 homozygous knockout mice (IL-10tm/tm [IL10KO]) constitute an excellent tool for the study of frailty. Because patients with frailty demonstrate an overexpression of CCR5, rapamycin (RAPA) and/or maraviroc (MVC), two molecules able to decrease CCR5 expression, were evaluated., [Results] Muscle myostatin was reduced in all the therapeutic groups but the MVC group (p <0.001 for RAPA and MVC-RAPA) and in serum samples (p <0.01 for all the groups). Serum CK levels were also significantly lower in MVC and RAPA groups (p <0.01 in both cases). Lower AST levels were observed in all the therapeutic groups (p <0.05 for all of them). The apoptotic effector caspase-3 was significantly lower in MVC and RAPA groups (p<0.05 in both cases). Combined treatment with MVC-RAPA showed a synergistic increase in p-AKT, p-mTOR and SIRT1 levels., [Conclusions] MVC and RAPA show a protective role in some factors involved in frailty. More studies are needed to prove their clinical applications., [Material and methods] Eighty male homozygous IL10KOs were randomly assigned to one of 4 groups (n= 20): i) IL10KO group (IL10KO); ii) IL10KO receiving MVC in drinking water (MVC group), iii) IL10KO receiving RAPA in drinking water (RAPA group), and finally, iv) MVC-RAPA group that received MVC and RAPA in drinking water. Blood and muscle samples were analysed. Survival analysis, frailty index calculation, and functional assessment were also performed.

Published
2020

45. Barriers to health care services for migrants living with HIV in Spain

Author

Ndumbi, Patricia, del Romero, J., Pulido, F., Velasco Arribas, M., Dronda, F., Blanco Ramos, J. Ramón, García de Olalla, P., Ocaña, I., Belda-Ibañez, J., del Amo, J., Álvarez-del Arco, D., Gennotte, Anne-Françoise, Barthélemy, C. cile La Morté, Wengenroth, Claudia, Touloumi, Giota, Ilias, Gountas, Loumpiana, Koulai, Olga, Anagnostou, Schüttfort, Gundolf, Wenganroth, Claudia, Barros, Henrique, Meireles, Paula, del Amo, Julia, Álvarez, D. bora, Monge, Susana, Ledergerber, Bruno, Staehelin, Cornelia, Prins, Maria, Bill, Janneke, Zuure, Freke, Prestileo, Tullio, Petrosillo, Nicolla, Burns, Fiona, Fakoya, Ibi, del Romero J, Jorge, Rodríguez, Carmen, Vera, Mar, Río, Isabel, Paredes, Vanessa, Sanz, Nieves, Dronda, Fernando, Arribas, María Velasco, Mateo, María Gracia, Gutiérrez, Mar, Domingo, Pere, Knobel, Hernando, Pellicer, Teresa, Fernández, Emma, del Carmen Ligero, María, Robau, Margarita, Miró, José María, Ocaña, Inmaculada, Burgos, Joaquín, Barberà, María José, Arando, Maider, Gutiérrez, F. lix, Masía, Mar, Blanco, José Ramón, Belda-Ibáñez, Josefina, García, Elisa Fernández, Espinosa, Trinidad Zafra, López-Lirola, Ana, Salavert, Miguel, Montero, Marta, Calabuig, Eva, Cuellar, Sandra, Vinciana, Pompeyo, Palacios, Reyes, García, Federico, Peña, Alejandro, Iribarren, José Antonio, Aguado, Mirian, Pulido, Federico, Portillo, Ángel, Gómez-Sirvent, José Luis, AII - Infectious diseases, Infectious diseases, and APH - Global Health

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Social stigma, Cross-sectional study, media_common.quotation_subject, Immigration, Stigma (botany), HIV Infections, Health Services Accessibility, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Epidemiology, Health care, Humans, Medicine, 030212 general & internal medicine, Young adult, Risk factor, media_common, Transients and Migrants, 030505 public health, business.industry, Public Health, Environmental and Occupational Health, Cross-Sectional Studies, Spain, Health Care Surveys, Female, 0305 other medical science, business, Demography
Abstract

Background In Spain, migrants are disproportionately affected by HIV and experience high rates of late diagnosis. We investigated barriers to health care access among migrants living with HIV (MLWH) in Spain. Methods Cross sectional electronic survey of 765 adult HIV-positive migrants recruited within 18 health care settings between July 2013 and July 2015. We collected epidemiological, demographic, behavioral and clinical data. We estimated the prevalence and risk factors of self-reported barriers to health care using multivariable logistic regression. Results Of those surveyed, 672 (88%) had information on health care access barriers: 23% were women, 63% from Latin America and Caribbean, 14% from Sub-Saharan Africa and 15% had an irregular immigration status. Men were more likely to report barriers than women (24% vs. 14%, P = 0.009). The main barriers were: lengthy waiting times for an appointment (9%) or in the clinic (7%) and lack of a health card (7%). Having an irregular immigration status was a risk factor for experiencing barriers for both men (OR: (4.0 [95%CI: 2.2-7.2]) and women (OR: 10.5 [95%CI: 3.1-34.8]). Men who experienced racial stigma (OR: 3.1 [95%CI: 1.9-5.1]) or food insecurity (OR: 2.1 [95%CI: 1.2-3.4]) were more likely to report barriers. Women who delayed treatment due to medication costs (6.3 [95%CI: 1.3-30.8]) or had a university degree (OR: 5.8 [95%CI: 1.3-25.1]) were more likely to report barriers. Conclusion Health care barriers were present in one in five5 MLWH, were more common in men and were associated to legal entitlement to access care, perceived stigma and financial constraints.

Published
2018
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46. Prevalence of Colorectal Neoplasms Among Patients With Enterococcus faecalis Endocarditis in the GAMES Cohort (2008–2017)

Author

Pericàs, Juan M., primary, Ambrosioni, Juan, additional, Muñoz, Patricia, additional, de Alarcón, Arístides, additional, Kestler, Martha, additional, Mari-Hualde, Amaia, additional, Moreno, Asunción, additional, Goenaga, Miguel Á., additional, Fariñas, M. Carmen, additional, Rodríguez-Álvarez, Regino, additional, Ojeda-Burgos, Guillermo, additional, Gálvez-Acebal, Juan, additional, Hidalgo-Tenorio, Carmen, additional, Noureddine, Mariam, additional, Miró, José M., additional, Sánchez, Fernando Fernández, additional, Rosas, Gabriel, additional, Lima, Javier de la Torre, additional, Blanco, Roberto, additional, Boado, María Victoria, additional, Lázaro, Marta Campaña, additional, Crespo, Alejandro, additional, Goikoetxea, Josune, additional, Iruretagoyena, José Ramón, additional, Zuazabal, Josu Irurzun, additional, López-Soria, Leire, additional, Montejo, Miguel, additional, Nieto, Javier, additional, Rodrigo, David, additional, Rodríguez, Regino, additional, Vitoria, Yolanda, additional, Voces, Roberto, additional, López, Ma Victoria García, additional, Georgieva, Radka Ivanova, additional, Ojeda, Guillermo, additional, Bailón, Isabel Rodríguez, additional, Morales, Josefa Ruiz, additional, Cuende, Ana María, additional, Echeverría, Tomás, additional, Fuerte, Ana, additional, Gaminde, Eduardo, additional, Goenaga, Miguel Ángel, additional, Idígoras, Pedro, additional, Iribarren, José Antonio, additional, Yarza, Alberto Izaguirre, additional, Urkola, Xabier Kortajarena, additional, Reviejo, Carlos, additional, Carrasco, Rafael, additional, Climent, Vicente, additional, Llamas, Patricio, additional, Merino, Esperanza, additional, Plazas, Joaquín, additional, Reus, Sergio, additional, Álvarez, Nemesio, additional, Bravo-Ferrer, José María, additional, Castelo, Laura, additional, Cuenca, José, additional, Llinares, Pedro, additional, Rey, Enrique Miguez, additional, Mayo, María Rodríguez, additional, Sánchez, Efrén, additional, Regueiro, Dolores Sousa, additional, Martínez, Francisco Javier, additional, del Mar Alonso, Ma, additional, Castro, Beatriz, additional, Rosado, Dácil García, additional, del Carmen Durán, Ma, additional, Gómez, Ma Antonia Miguel, additional, Lacalzada, Juan, additional, Nassar, Ibrahim, additional, Ciezar, Antonio Plata, additional, Iglesias, José Ma Reguera, additional, Álvarez, Víctor Asensi, additional, Costas, Carlos, additional, Hera, Jesús de la, additional, Suárez, Jonnathan Fernández, additional, Fraile, Lisardo Iglesias, additional, Arguero, Víctor León, additional, Menéndez, José López, additional, Bajo, Pilar Mencia, additional, Morales, Carlos, additional, Torrico, Alfonso Moreno, additional, Palomo, Carmen, additional, Martínez, Begoña Paya, additional, Esteban, Ángeles Rodríguez, additional, García, Raquel Rodríguez, additional, Asensio, Mauricio Telenti, additional, Almela, Manuel, additional, Azqueta, Manuel, additional, Brunet, Mercè, additional, Bodro, Marta, additional, Cartañá, Ramón, additional, Falces, Carlos, additional, Fita, Guillermina, additional, Fuster, David, additional, García de la Mària, Cristina, additional, García-Pares, Delia, additional, Hernández-Meneses, Marta, additional, Pérez, Jaume Llopis, additional, Marco, Francesc, additional, Nicolás, David, additional, Ninot, Salvador, additional, Quintana, Eduardo, additional, Paré, Carlos, additional, Pereda, Daniel, additional, Pericás, Juan M., additional, Pomar, José L., additional, Ramírez, José, additional, Rovira, Irene, additional, Sandoval, Elena, additional, Sitges, Marta, additional, Soy, Dolors, additional, Téllez, Adrián, additional, Tolosana, José M., additional, Vidal, Bárbara, additional, Vila, Jordi, additional, Adán, Iván, additional, Bermejo, Javier, additional, Bouza, Emilio, additional, Celemín, Daniel, additional, Caballero, Gregorio Cuerpo, additional, Montero, Antonia Delgado, additional, Mansilla, Ana García, additional, Leoni, Ma Eugenia García, additional, Ramallo, Víctor González, additional, Hernández, Martha Kestler, additional, Hualde, Amaia Mari, additional, Marín, Mercedes, additional, Martínez-Sellés, Manuel, additional, Rincón, Cristina, additional, Rodríguez-Abella, Hugo, additional, Rodríguez-Créixems, Marta, additional, 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Domínguez, Fernando, additional, Fortaleza, Alberto, additional, Pavía, Pablo García, additional, González, Jesús, additional, Cruz, Ana Fernández, additional, Múñez, Elena, additional, Ramos, Antonio, additional, Romero, Isabel Sánchez, additional, Centella, Tomasa, additional, Hermida, José Manuel, additional, Moya, José Luis, additional, Martín-Dávila, Pilar, additional, Navas, Enrique, additional, Oliva, Enrique, additional, Río, Alejandro del, additional, Rodríguez-Roda Stuart, Jorge, additional, Ruiz, Soledad, additional, Tenorio, Carmen Hidalgo, additional, Delia, Manuel Almendro, additional, Araji, Omar, additional, Barquero, José Miguel, additional, Jambrina, Román Calvo, additional, de Cueto, Marina, additional, Acebal, Juan Gálvez, additional, Méndez, Irene, additional, Morales, Isabel, additional, López-Cortés, Luis Eduardo, additional, García, Emilio, additional, Haro, Juan Luis, additional, Lepe, José Antonio, additional, López, Francisco, additional, Luque, Rafael, 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additional, Abad, Nuria Fernández, additional, Mangas, Pilar García, additional, Adell, Marta Matamala, additional, Ruiz, Ma Pilar Palacián, additional, Porres, Juan Carlos, additional, Vidal, Begoña Alcaraz, additional, Trigueros, Nazaret Cobos, additional, Del Amor Espín, María Jesús, additional, Giner Caro, José Antonio, additional, Sánchez, Roberto Jiménez, additional, Almazán, Amaya Jimeno, additional, Freire, Alejandro Ortín, additional, González, Monserrat Viqueira, additional, Ramis, Pere Pericás, additional, Blanco, Ma Ángels Ribas, additional, Ruiz de Gopegui Bordes, Enrique, additional, Bonet, Laura Vidal, additional, Munera, Ma Carmen Bellón, additional, Garaizabal, Elena Escribano, additional, Martínez, Antonia Tercero, additional, Segura Luque, Juan Carlos, additional, Badía, Cristina, additional, Palop, Lucía Boix, additional, Xercavins, Mariona, additional, Eloy Gómez Nebreda, Sónia Ibars., additional, Herrera, Ibalia Horcajada, additional, Gallego Héctor Marrero Santiago, Irene Menduiña, additional, de Miguel Martínez, Isabel, additional, and Álamo, Elena Pisos, additional

Published
2021
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50. Psychological distress in women and men living with HIV in Spain: a cross-sectional telephone survey

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Garriga, Cesar, primary, Gutiérrez Trujillo, Lourdes, additional, Del Romero, Jorge, additional, Montero, Marta, additional, Pérez-Elías, María Jesús, additional, Culqui Lévano, Dante, additional, Gutierrez, Félix, additional, Gómez-Sirvent, Juan Luis, additional, Peña-Monje, Alejandro, additional, Blanco, José Ramón, additional, and Rodríguez-Arenas, María Angeles, additional

Published
2020
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