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Català: Agafant com a referència una aplicació de complexitat relativament baixa, com és en el nostre cas Twitter, mirar de re dissenyar-la per tal que estigui formada per un bon nombre de components de la granularitat més fina possible, per tal que desplegar-la en un entorn completament descentralitzat permeti un millor aprofitament dels recursos. En una societat tecnològica com l'actual, sempre hi ha demanda de serveis software. Aixó ha provocat que una tecnologia com és el Cloud Computing, l'objectiu de la qual és aconseguir una manera eficaç i eficient de respondre a aquesta demanda de serveis, ocupin gran part de la investigació i desenvolupament informàtics actuals. Així ha nascut la idea de CoDeS, un sistema de cloud desenvolupat per un equip universitari català, en el qual no hi ha màquines dedicades sino que s'aprofita al màxim els recursos que els usuaris cedeixen voluntàriament a la xarxa. Ens trobem davant d'una tendència en alça, i creiem que desenvolupar una aplicació d'aquestes característiques pot resultar en una bona oportunitat per a aprendre a desenvolupar un tipus de productes que, cada cop més, aniran sent productes informàtics quotidians.

The olfactory system represents one of the most suitable models to study interactions between the peripheral and central nervous systems. The developing olfactory epithelium (olfactory placode and pit) gives rise to several cell populations that migrate towards the telencephalic vesicle. One of these cell populations, called the Migratory Mass (MM), accompanies the first emerging olfactory axons from the olfactory placode, but the fate of these cells and their contribution to the Olfactory Bulb (OB) populations has not been properly addressed. To asses this issue we performed ultrasound-guided in utero retroviral injections at embryonic day (E) 11 revealing the MM as an early source of Olfactory Ensheathing Cells in later postnatal stages. Employing a wide number of antibodies to identify the nature of the infected cells we described that those cells generated within the MM at E11 belong to different cell populations both in the mesenchyma, where they envelop olfactory axons and express the most common glial markers, and in the olfactory bulb, where they are restricted to the Olfactory Nerve and Glomerular layers. Thus, the data reveal the existence of a novel progenitor class within the MM, potentially derived from the olfactory placode which gives rise to different neural cell population including some CNS neurons, glia and olfactory ensheathing cells. © 2010 Wiley-Liss, Inc.

Dab1 mediates reelin signalling and plays critical roles in early brain development such as the stereotypical positioning of neurons in the brain. The olfactory bulb undergoes a prominent layering reorganization, but shows not apparent differences between wild type and reeler in the layer organization. Therefore, an accurate regional and cellular simultaneous analysis of these molecules becomes essential to clarify the role played by Dab1 upon Reelin effect. The present study reveals a strong and consistent Dab1 mRNA and protein expressions, throughout the olfactory bulb layers in both wild type and reeler mice. In addition, noteworthy is the pattern of Dab1 location within cell nuclei in both strains. Furthermore, a temporal increment of Dab1 expression levels is detected from P0 to P15 in both strains, being the protein quantity higher in reeler than in wild type mice. Altogether, our results revealed that Reln acts directly from projection neurons via the production of different Reln fragments. Changes in the pattern of Dab1 expression could reflect an alternative Reln function in postnatal and adult stages, besides a possible regulation of Dab1 by other molecules distinct to Reln.