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1. CT Imaging Assessment of Response to Treatment in Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma

Author

Mal, Hervé, Le Guen, Pierre, Dupin, Clairelyne, Meurice, Jean Claude, Verdaguer, Marion, de Keizer, Joe, Delétage-Métreau, Céline, Le Mao, Raphael, Tromer, Cécile, Fajole, Gaëlle, Rayez, Mélanie, Raymond, Christel Saint, Gheerbrant, Hubert, Badatcheff, Anne, Person, Christine, Macey, Julie, Dermant, Xavier, Boitiaux, Jean-François, Gosset-Woimant, Marine, Metz-Favre, Carine, Degot, Tristan, Poulet, Claire, Popin, Elisabeth, Gamez, Anne Sophie, Boissin, Clément, Prevotat, Anne, Mangiapan, Gilles, Brouquières, Danielle, Le Floch, Hervé, Morisse-Pradier, Hélène, Sattler, Caroline, Muti, Daniela, Germaud, Patrick, Dirou, Stéphanie, Paris, Audrey, Melloni, Boris, Ballouhey, Julia, Bondeelle, Louise, Laurent, Lucie, Belleguic, Chantal, Kerjouan, Mallorie, Deslée, Gaëtan, Dury, Sandra, Bergot, Emmanuel, Magnier, Romain, Morel, Hugues, Lemaire, Bertrand, Tumino, Cécile, Sénéchal, Agathe, Choinier, Pascaline, Parrot, Antoine, Godet, Cendrine, Brun, Anne-Laure, Couturaud, Francis, Laurent, François, Frat, Jean-Pierre, Marchand-Adam, Sylvain, Gagnadoux, Frédéric, Blanchard, Elodie, Taillé, Camille, Philippe, Bruno, Hirschi, Sandrine, Andréjak, Claire, Bourdin, Arnaud, Chenivesse, Cécile, Dominique, Stéphane, Murris-Espin, Marlène, Rivière, Frédéric, Garcia, Gilles, Blanc, François-Xavier, Goupil, François, Bergeron, Anne, Flament, Thomas, Priou, Pascaline, Ragot, Stéphanie, and Cadranel, Jacques

Published
2024
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3. Improving Diagnosis of Pulmonary Mucormycosis: Leads From a Contemporary National Study of 114 Cases

Author

Freymond, Nathalie, Sénéchal, Agathe, Belhabri, Amine, Menotti, Jean, Persat, Florence, Coste, Anne, Conrad, Anne, Porcher, Raphaël, Poirée, Sylvain, Peterlin, Pierre, Defrance, Claire, Letscher-Bru, Valérie, Morio, Florent, Gastinne, Thomas, Bougnoux, Marie-Elisabeth, Suarez, Felipe, Nevez, Gilles, Dupont, Damien, Ader, Florence, Halfon-Domenech, Carine, Ducastelle-Leprêtre, Sophie, Botterel, Françoise, Millon, Laurence, Guillerm, Gaelle, Ansart, Séverine, Boutoille, David, Ledoux, Marie-Pierre, Herbrecht, Jean-Etienne, Robin, Christine, Melica, Giovanna, Danion, François, Blanchard, Elodie, Paccoud, Olivier, Garcia-Hermoso, Dea, Lortholary, Olivier, Herbrecht, Raoul, and Lanternier, Fanny

Published
2023
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4. French recommendations for the diagnosis and management of lymphangioleiomyomatosis

Author

Cottin, Vincent, Blanchard, Elodie, Kerjouan, Mallorie, Lazor, Romain, Reynaud-Gaubert, Martine, Taille, Camille, Uzunhan, Yurdagül, Wemeau, Lidwine, Andrejak, Claire, Baud, Dany, Bonniaud, Philippe, Brillet, Pierre-Yves, Calender, Alain, Chalabreysse, Lara, Court-Fortune, Isabelle, Desbaillets, Nicolas Pierre, Ferretti, Gilbert, Guillemot, Anne, Hardelin, Laurane, Kambouchner, Marianne, Leclerc, Violette, Lederlin, Mathieu, Malinge, Marie-Claire, Mancel, Alain, Marchand-Adam, Sylvain, Maury, Jean-Michel, Naccache, Jean-Marc, Nasser, Mouhamad, Nunes, Hilario, Pagnoux, Gaële, Prévot, Grégoire, Rousset-Jablonski, Christine, Rouviere, Olivier, Si-Mohamed, Salim, Touraine, Renaud, Traclet, Julie, Turquier, Ségolène, Vagnarelli, Stéphane, and Ahmad, Kaïs

Published
2023
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5. French practical guidelines for the diagnosis and management of idiopathic pulmonary fibrosis – 2021 update. Full-length version

Author

Cottin, Vincent, Bonniaud, Philippe, Cadranel, Jacques, Crestani, Bruno, Jouneau, Stéphane, Marchand-Adam, Sylvain, Nunes, Hilario, Wémeau-Stervinou, Lidwine, Bergot, Emmanuel, Blanchard, Elodie, Borie, Raphaël, Bourdin, Arnaud, Chenivesse, Cécile, Clément, Annick, Gomez, Emmanuel, Gondouin, Anne, Hirschi, Sandrine, Lebargy, François, Marquette, Charles-Hugo, Montani, David, Prévot, Grégoire, Quetant, Sébastien, Reynaud-Gaubert, Martine, Salaun, Mathieu, Sanchez, Olivier, Trumbic, Bruno, Berkani, Karim, Brillet, Pierre-Yves, Campana, Marion, Chalabreysse, Lara, Chatté, Gérard, Debieuvre, Didier, Ferretti, Gilbert, Fourrier, Jean-Michel, Just, Nicolas, Kambouchner, Marianne, Legrand, Bertrand, Le Guillou, Frédéric, Lhuillier, Jean-Pierre, Mehdaoui, Anas, Naccache, Jean-Marc, Paganon, Catherine, Rémy-Jardin, Martine, Si-Mohamed, Salim, and Terrioux, Philippe

Published
2023
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7. Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Naccache, Jean-Marc, Jouneau, Stéphane, Didier, Morgane, Borie, Raphaël, Cachanado, Marine, Bourdin, Arnaud, Reynaud-Gaubert, Martine, Bonniaud, Philippe, Israël-Biet, Dominique, Prévot, Grégoire, Hirschi, Sandrine, Lebargy, François, Marchand-Adam, Sylvain, Bautin, Nathalie, Traclet, Julie, Gomez, Emmanuel, Leroy, Sylvie, Gagnadoux, Frédéric, Rivière, Frédéric, Bergot, Emmanuel, Gondouin, Anne, Blanchard, Elodie, Parrot, Antoine, Blanc, François-Xavier, Chabrol, Alexandre, Dominique, Stéphane, Gibelin, Aude, Tazi, Abdellatif, Berard, Laurence, Brillet, Pierre Yves, Debray, Marie-Pierre, Rousseau, Alexandra, Kerjouan, Mallorie, Freynet, Olivia, Dombret, Marie-Christine, Gamez, Anne-Sophie, Nieves, Ana, Beltramo, Guillaume, Pastré, Jean, Le Borgne-Krams, Aurélie, Dégot, Tristan, Launois, Claire, Plantier, Laurent, Wémeau-Stervinou, Lidwine, Cadranel, Jacques, Chenivesse, Cécile, Valeyre, Dominique, Crestani, Bruno, Cottin, Vincent, Simon, Tabassome, and Nunes, Hilario

Published
2022
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8. Convalescent plasma transfusion for immunocompromised viremic patients with COVID‐19: A retrospective multicenter study

Author

Destremau, Marjolaine, primary, Chaussade, Hélène, additional, Hemar, Victor, additional, Beguet, Mathilde, additional, Bellecave, Pantxika, additional, Blanchard, Elodie, additional, Barret, Amaury, additional, Laboure, Gaelle, additional, Vasco‐Moynet, Claire, additional, Lacassin, Flore, additional, Morisse, Eloïse, additional, Aguilar, Claire, additional, Lafarge, Xavier, additional, Lafon, Marie‐Edith, additional, Bonnet, Fabrice, additional, Issa, Nahéma, additional, and Camou, Fabrice, additional

Published
2024
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10. CT Imaging Assessment of Response to Treatment in Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma.

Author

Godet, Cendrine, Brun, Anne-Laure, Couturaud, Francis, Laurent, François, Frat, Jean-Pierre, Marchand-Adam, Sylvain, Gagnadoux, Frédéric, Blanchard, Elodie, Taillé, Camille, Philippe, Bruno, Hirschi, Sandrine, Andréjak, Claire, Bourdin, Arnaud, Chenivesse, Cécile, Dominique, Stéphane, Mangiapan, Gilles, Murris-Espin, Marlène, Rivière, Frédéric, Garcia, Gilles, and Blanc, François-Xavier

Subjects
PULMONARY aspergillosis, ASTHMA, COMPUTED tomography, END of treatment, ADULTS
Abstract

One of the major challenges in managing allergic bronchopulmonary aspergillosis remains consistent and reproducible assessment of response to treatment. What are the most relevant changes in CT scan parameters over time for assessing response to treatment? In this ancillary study of a randomized clinical trial (NebuLamB), patients with asthma with available CT scan and without exacerbation during a 4-month allergic bronchopulmonary aspergillosis exacerbation treatment period (corticosteroids and itraconazole) were included. Changed CT scan parameters were assessed by systematic analyses of CT scan findings at initiation and end of treatment. CT scans were assessed by two radiologists anonymized to the clinical data. Radiologic parameters were determined by selecting those showing significant changes over time. Improvement of at least one, without worsening of the others, defined the radiologic response. Agreement between radiologic changes and clinical and immunologic responses was likewise investigated. Among the 139 originally randomized patients, 132 were included. We identified five CT scan parameters showing significant changes at end of treatment: mucoid impaction extent, mucoid impaction density, centrilobular micronodules, consolidation/ground-glass opacities, and bronchial wall thickening (P <.05). These changes were only weakly associated with one another, except for mucoid impaction extent and density. No agreement was observed between clinical, immunologic, and radiologic responses, assessed as an overall response, or considering each of the parameters (Cohen κ, −0.01 to 0.24). Changes in extent and density of mucoid impaction, centrilobular micronodules, consolidation/ground-glass opacities, and thickening of the bronchial walls were found to be the most relevant CT scan parameters to assess radiologic response to treatment. A clinical, immunologic, and radiologic multidimensional approach should be adopted to assess outcomes, probably with a composite definition of response to treatment. ClinicalTrials.gov; No.: NCT02273661; URL: www.clinicaltrials.gov) [ABSTRACT FROM AUTHOR]

Published
2024
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12. Characterization of novel mutations in the TEL-patch domain of the telomeric factor TPP1 associated with telomere biology disorders

Author

Bertrand, Alexis, primary, Ba, Ibrahima, additional, Kermasson, Laëtitia, additional, Pirabakaran, Vithura, additional, Chable, Noémie, additional, Lainey, Elodie, additional, Ménard, Christelle, additional, Kallel, Faten, additional, Picard, Capucine, additional, Hadiji, Sondes, additional, Coolen-Allou, Nathalie, additional, Blanchard, Elodie, additional, de Villartay, Jean-Pierre, additional, Moshous, Despina, additional, Roelens, Marie, additional, Callebaut, Isabelle, additional, Kannengiesser, Caroline, additional, and Revy, Patrick, additional

Published
2024
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13. Microglial Cells Prevent Hemorrhage in Neonatal Focal Arterial Stroke

Author

Fernández-López, David, Faustino, Joel, Klibanov, Alexander L, Derugin, Nikita, Blanchard, Elodie, Simon, Franziska, Leib, Stephen L, and Vexler, Zinaida S

Subjects
Brain Disorders, Stroke, Neurosciences, Pediatric, Aetiology, 2.1 Biological and endogenous factors, Age Factors, Animals, Animals, Newborn, Benzamides, Bone Density Conservation Agents, Caspase 3, Clodronic Acid, Dioxoles, Disease Models, Animal, Endothelial Cells, Female, Gene Expression Regulation, Developmental, Infarction, Middle Cerebral Artery, Intracranial Hemorrhages, Male, Mice, Mice, Transgenic, Microglia, Rats, Signal Transduction, Smad2 Protein, Transforming Growth Factor beta1, blood-brain barrier, extracellular matrix, inflammation, middle cerebral artery occlusion, postnatal, TGF beta 1, TGFβ1, blood–brain barrier, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

Perinatal stroke leads to significant morbidity and long-term neurological and cognitive deficits. The pathophysiological mechanisms of brain damage depend on brain maturation at the time of stroke. To understand whether microglial cells limit injury after neonatal stroke by preserving neurovascular integrity, we subjected postnatal day 7 (P7) rats depleted of microglial cells, rats with inhibited microglial TGFbr2/ALK5 signaling, and corresponding controls, to transient middle cerebral artery occlusion (tMCAO). Microglial depletion by intracerebral injection of liposome-encapsulated clodronate at P5 significantly reduced vessel coverage and triggered hemorrhages in injured regions 24 h after tMCAO. Lack of microglia did not alter expression or intracellular redistribution of several tight junction proteins, did not affect degradation of collagen IV induced by the tMCAO, but altered cell types producing TGFβ1 and the phosphorylation and intracellular distribution of SMAD2/3. Selective inhibition of TGFbr2/ALK5 signaling in microglia via intracerebral liposome-encapsulated SB-431542 delivery triggered hemorrhages after tMCAO, demonstrating that TGFβ1/TGFbr2/ALK5 signaling in microglia protects from hemorrhages. Consistent with observations in neonatal rats, depletion of microglia before tMCAO in P9 Cx3cr1(GFP/+)/Ccr2(RFP/+) mice exacerbated injury and induced hemorrhages at 24 h. The effects were independent of infiltration of Ccr2(RFP/+) monocytes into injured regions. Cumulatively, in two species, we show that microglial cells protect neonatal brain from hemorrhage after acute ischemic stroke.

Published
2016

14. Management of patients with pulmonary mycobacteriosis in France: a multicenter retrospective cohort study

Author

Bemer, Pascale, Peuchant, Olivia, Guet-Revillet, Hélène, Bador, Julien, Balavoine, Charlotte, Basille, Damien, Beltramo, Guillaume, Blanc, François-Xavier, Blanchard, Elodie, Boulanger, Sarah, Bourgoin, Anne, Boutoille, David, Cambau, Emmanuelle, Canis, Frédérique, Caparros, Didier, Carricajo, Anne, Carrière, Christian, Couetdic, Gérard, Couturaud, Francis, Dalphin, Jean-Charles, Degot, Tristan, Desquiens, Marion, Devouassoux, Gilles, Duez, Jean-Marie, Dumitrescu, Oana, Dupuy-Grasset, Magali, Gaudart, Alice, Georges, Marjolaine, Godet, Cendrine, Godreuil, Sylvain, Guillouzouic, Aurélie, Hamdad-Daoudi, Farida, Héry-Arnaud, Geneviève, Koebel, Christelle, Lagrange, Aurore, Lanotte, Philippe, Marchand-Adam, Sylvain, Mougari, Faïza, Murris, Marlène, Patry, Isabelle, Pérouse de Montclos, Michèle, Raskine, Laurent, Risso, Karine, Segonds, Christine, Sicard, Dominique, Terru, Dominique, Vachée, Anne, Vergnon, Jean-Michel, Martin, Christian, Schramm, Frédéric, and Andrejak, Claire

Published
2021
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15. Contributors

Author

Adams, Janine B., primary, Anthony, Edward J., additional, Arifanti, Virni Budi, additional, Ascough, Philippa, additional, Balke, Thorsten, additional, Banda, Sinegugu P., additional, Beavis, Sara, additional, Berger, Uta, additional, Blanchard, Elodie, additional, Cahoon, Donald R., additional, Chen, Luzhen, additional, Chen, Yining, additional, de Lacerda, Luiz Drude, additional, Eggins, Stephen, additional, Ellison, Joanna C., additional, Feng, Hongyu, additional, Friess, Daniel A., additional, Gardel, Antoine, additional, Gillis, Lucy Gwen, additional, Hassenrück, Christiane, additional, Helfer, Véronique, additional, Huhn, Katrin, additional, Jana, Tapan Kumar, additional, Jennerjahn, Tim C., additional, Johnson, Jaime Leigh, additional, Kelleway, Jeff, additional, Krauss, Ken W., additional, Kusuma, Denny Wijaya, additional, Le Minor, Marine, additional, Lovelock, Catherine E., additional, Lupascu, Massimo, additional, MacKenzie, Richard, additional, Macklin, Paul, additional, McBride, Graham B., additional, McKee, Karen L., additional, Ong, Wei Jian, additional, Pritchard, Mark, additional, Priyono, Bayu, additional, Proisy, Christophe, additional, Rajkaran, Anusha, additional, Raw, Jacqueline L., additional, Ray, Raghab, additional, Roderick, Michael, additional, Rogers, Kerrylee, additional, Rosentreter, Judith, additional, Rovai, Andre S., additional, Saintilan, Neil, additional, Salmo, Severino G., additional, Sasmito, Sigit D., additional, Sefton, Juliet, additional, Sharma, Sahadev, additional, Sidik, Frida, additional, Sillanpää, Mériadec, additional, Sugoro, Irawan, additional, Sukardjo, Sukristijono, additional, Suryaputra, I Gusti Ngurah Agung, additional, Swales, Andrew, additional, Taberima, Sartji, additional, Teo, Rui Xiang, additional, Twilley, Robert R., additional, Ulumuddin, Yaya I., additional, Vovides, Alejandra G., additional, Vulpas, Susan, additional, Walcker, Romain, additional, Ward, Raymond D., additional, Woodroffe, Sarah, additional, Yudha, Ruhuddien Pandu, additional, Zhang, Yihui, additional, and Zimmer, Martin, additional

Published
2021
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17. Similarities and differences of interstitial lung disease associated with pathogenic variants in SFTPC and ABCA3 in adults.

Author

Diesler, Rémi, Legendre, Marie, Si‐Mohamed, Salim, Brillet, Pierre‐Yves, Wemeau, Lidwine, Manali, Effrosyni D., Gagnadoux, Frédéric, Hirschi, Sandrine, Lorillon, Gwenaël, Reynaud‐Gaubert, Martine, Bironneau, Vanessa, Blanchard, Elodie, Bourdin, Arnaud, Dominique, Stéphane, Justet, Aurélien, Macey, Julie, Marchand‐Adam, Sylvain, Morisse‐Pradier, Hélène, Nunes, Hilario, and Papiris, Spyros A.

Subjects
INTERSTITIAL lung diseases, IDIOPATHIC pulmonary fibrosis, PULMONARY fibrosis, ADULTS, COMPUTED tomography, LUNG transplantation
Abstract

Background and Objective: Variants in surfactant genes SFTPC or ABCA3 are responsible for interstitial lung disease (ILD) in children and adults, with few studies in adults. Methods: We conducted a multicentre retrospective study of all consecutive adult patients diagnosed with ILD associated with variants in SFTPC or ABCA3 in the French rare pulmonary diseases network, OrphaLung. Variants and chest computed tomography (CT) features were centrally reviewed. Results: We included 36 patients (median age: 34 years, 20 males), 22 in the SFTPC group and 14 in the ABCA3 group. Clinical characteristics were similar between groups. Baseline median FVC was 59% ([52–72]) and DLco was 44% ([35–50]). An unclassifiable pattern of fibrosing ILD was the most frequent on chest CT, found in 85% of patients, however with a distinct phenotype with ground‐glass opacities and/or cysts. Nonspecific interstitial pneumonia and usual interstitial pneumonia were the most common histological patterns in the ABCA3 group and in the SFTPC group, respectively. Annually, FVC and DLCO declined by 1.87% and 2.43% in the SFTPC group, respectively, and by 0.72% and 0.95% in the ABCA3 group, respectively (FVC, p = 0.014 and DLCO, p = 0.004 for comparison between groups). Median time to death or lung transplantation was 10 years in the SFTPC group and was not reached at the end of follow‐up in the ABCA3 group. Conclusion: SFTPC and ABCA3‐associated ILD present with a distinct phenotype and prognosis. A radiologic pattern of fibrosing ILD with ground‐glass opacities and/or cysts is frequently found in these rare conditions. [ABSTRACT FROM AUTHOR]

Published
2024
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18. P-190 Transfusion de plasma de patients convalescents chez les immunodéprimés atteints de COVID-19 virémique: une étude rétrospective multicentrique

Author

Destremau, Marjolaine, primary, Beguet-Yachine, Mathilde, additional, Hemar, Victor, additional, Chaussade, Hélène, additional, Lafarge, Xavier, additional, Bellecave, Pantxika, additional, Lafon, Marie-Edith, additional, Blanchard, Elodie, additional, Bonnet, Fabrice, additional, Issa, Nahéma, additional, and Camou, Fabrice, additional

Published
2023
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19. Improving Diagnosis of Pulmonary Mucormycosis

Author

Coste, Anne, primary, Conrad, Anne, additional, Porcher, Raphaël, additional, Poirée, Sylvain, additional, Peterlin, Pierre, additional, Defrance, Claire, additional, Letscher-Bru, Valérie, additional, Morio, Florent, additional, Gastinne, Thomas, additional, Bougnoux, Marie-Elisabeth, additional, Suarez, Felipe, additional, Nevez, Gilles, additional, Dupont, Damien, additional, Ader, Florence, additional, Halfon-Domenech, Carine, additional, Ducastelle-Leprêtre, Sophie, additional, Botterel, Françoise, additional, Millon, Laurence, additional, Guillerm, Gaelle, additional, Ansart, Séverine, additional, Boutoille, David, additional, Ledoux, Marie-Pierre, additional, Herbrecht, Jean-Etienne, additional, Robin, Christine, additional, Melica, Giovanna, additional, Danion, François, additional, Blanchard, Elodie, additional, Paccoud, Olivier, additional, Garcia-Hermoso, Dea, additional, Lortholary, Olivier, additional, Herbrecht, Raoul, additional, Lanternier, Fanny, additional, Freymond, Nathalie, additional, Sénéchal, Agathe, additional, Belhabri, Amine, additional, Menotti, Jean, additional, and Persat, Florence, additional

Published
2023
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20. Infections in autoimmune pulmonary alveolar proteinosis: a large retrospective cohort

Author

Mabo, Axelle, primary, Borie, Raphael, additional, Wemeau-Stervinou, Lidwine, additional, Uzunhan, Yurdagül, additional, Gomez, Emmanuel, additional, Prevot, Gregoire, additional, Reynaud-Gaubert, Martine, additional, Traclet, Julie, additional, Bergot, Emmanuel, additional, Cadranel, Jacques, additional, Marchand-Adam, Sylvain, additional, Bergeron, Anne, additional, Blanchard, Elodie, additional, Bondue, Benjamin, additional, Bonniaud, Philippe, additional, Bourdin, Arnaud, additional, Burgel, Pierre Regis, additional, Hirschi, Sandrine, additional, Marquette, Charles Hugo, additional, Quétant, Sébastien, additional, Nunes, Hilario, additional, Chenivesse, Cécile, additional, Crestani, Bruno, additional, Guirriec, Yoann, additional, Monnier, Delphine, additional, Ménard, Cédric, additional, Tattevin, Pierre, additional, Cottin, Vincent, additional, Luque Paz, David, additional, and Jouneau, Stéphane, additional

Published
2023
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21. Phenotypic characterization of interstitial lung disease associated with mutations in SFTPC and ABCA3 in adults

Author

Diesler, Rémi, primary, Legendre, Marie, additional, Si-Mohamed, Salim, additional, Brillet, Pierre-Yves, additional, Wemeau, Lidwine, additional, Manali, Effrosyni D, additional, Gagnadoux, Frédéric, additional, Gondouin, Anne, additional, Hirschi, Sandrine, additional, Lorillon, Gwenael, additional, Reynaud-Gaubert, Martine, additional, Bironneau, Vanessa, additional, Blanchard, Elodie, additional, Bourdin, Arnaud, additional, Dominique, Stéphane, additional, Justet, Aurélien, additional, Macey, Julie, additional, Marchand-Adam, Sylvain, additional, Morisse-Pradier, Hélène, additional, Nunes, Hilario, additional, Papiris, Spyros, additional, Traclet, Julie, additional, Crestani, Bruno, additional, Amsellem, Serge, additional, Nathan, Nadia, additional, Borie, Raphaël, additional, and Cottin, Vincent, additional

Published
2023
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22. Functional pattern of baseline lung allograft dysfunction after lung transplantation.

Author

Bon, Martin, primary, Verdy, Guillaume, additional, Bon, Claire, additional, Blanchard, Elodie, additional, Macey, Julie, additional, Golhen, Hadrien, additional, Boisselier, Clement, additional, Repusseau, Benjamin, additional, Seramondi, Régis, additional, Reynier, Patrick, additional, Bonnardel, Eline, additional, Pellerin, Christelle, additional, Ridolfo, Jerome, additional, Gallo, Eloise, additional, Khan, Pierre, additional, Roze, Hadrien, additional, Rodriguez, Arnaud, additional, Belaroussi, Yaniss, additional, Chevalier, Benjamin, additional, Delcambre, Frederic, additional, Thumerel, Matthieu, additional, Jougon, Jacques, additional, and Demant, Xavier, additional

Published
2023
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23. Infections in autoimmune pulmonary alveolar proteinosis: a large retrospective cohort.

Author

Mabo, Axelle, Borie, Raphael, Wemeau-Stervinou, Lidwine, Uzunhan, Yurdagül, Gomez, Emmanuel, Prevot, Gregoire, Reynaud-Gaubert, Martine, Traclet, Julie, Bergot, Emmanuel, Cadranel, Jacques, Marchand-Adam, Sylvain, Bergeron, Anne, Blanchard, Elodie, Bondue, Benjamin, Bonniaud, Philippe, Bourdin, Arnaud, Burgel, Pierre Regis, Hirschi, Sandrine, Marquette, Charles Hugo, and Quétant, Sébastien

Subjects
PULMONARY alveolar proteinosis, LUNG infections
Published
2024
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28. Outcomes of targeted treatment in immunocompromised patients with asymptomatic or mild COVID-19: a retrospective study.

Author

Lahouati, M., Cazanave, C., Labadie, A., Gohier, P., Guirlé, L., Desclaux, A., Gigan, M., Malvy, D., Pedeboscq, S., Xuereb, F., Duvignaud, A., The Bordeaux COVID-19 Treatment Group, Barthod, Laure, Bellecave, Pantxika, Blanc, Jean-Frédéric, Blanchard, Elodie, Bonnet, Fabrice, Camou, Fabrice, Carrer, Mathilde, and Cazanave, Charles

Subjects
ASYMPTOMATIC patients, IMMUNOCOMPROMISED patients, COVID-19 pandemic, COVID-19 treatment, SARS-CoV-2 Omicron variant, COVID-19
Abstract

The aim of this study was to describe the outcomes of targeted COVID-19 treatments in immunocompromised patients with asymptomatic or mild COVID-19 during the period of expansion of the different Omicron subvariants in France. A retrospective monocentric observational study was performed. All immunocompromised patients aged 18 or more, with asymptomatic SARS-CoV-2 infection or mild COVID-19, and who had received a targeted treatment with sotrovimab, tixagevimab/cilgavimab, nirmatrelvir/ritonavir or remdesivir at the Bordeaux University Hospital from 1st January 2022 to 31st December 2022 were eligible. The primary outcomes of interest was defined as a composite of either (i) progression to moderate (WHO-Clinical Progression Scale at 4 or 5) or severe COVID-19 (WHO-CPS ≥ 6), or (ii) the occurrence of COVID-19-related death. The secondary outcomes of interest were the components of the primary outcome. Outcomes were collected until day 30 after targeted treatment administration or at discharge for patients still hospitalised in relation with COVID-19 at day 30. 223 immunocompromised patients received targeted treatment for asymptomatic SARS-CoV-2 infection or mild COVID-19: 114 received sotrovimab, 50 tixagevimab/cilgavimab, 49 nirmatrelvir/ritonavir, and 10 remdesivir. Among 223 treated patients, 10 (4.5%) progressed to moderate or severe disease: three patients (1.3%) progressed to moderate COVID-19 and 7 (3.1%) patients progressed to severe disease. Among them, 4 (1.8%) died of COVID-19. More than 95% of immunocompromised patients with asymptomatic SARS-CoV-2 infection or mild COVID-19 treated by targeted therapies during the Omicron subvariants era did not progress to moderate or severe disease. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Respiratory recovery trajectories after severe-to-critical COVID-19: a 1-year prospective multicentre study

Author

Schlemmer, Frédéric, primary, Valentin, Simon, additional, Boyer, Laurent, additional, Guillaumot, Anne, additional, Chabot, François, additional, Dupin, Clairelyne, additional, Le Guen, Pierre, additional, Lorillon, Gwenael, additional, Bergeron, Anne, additional, Basille, Damien, additional, Delomez, Julia, additional, Andrejak, Claire, additional, Bonnefoy, Valentine, additional, Goussault, Hélène, additional, Assié, Jean-Baptiste, additional, Choinier, Pascaline, additional, Ruppert, Anne-Marie, additional, Cadranel, Jacques, additional, Mennitti, Maria Chiara, additional, Roumila, Mehdi, additional, Colin, Charlotte, additional, Günther, Sven, additional, Sanchez, Olivier, additional, Gille, Thomas, additional, Sésé, Lucile, additional, Uzunhan, Yurdagul, additional, Faure, Morgane, additional, Patout, Maxime, additional, Morelot-Panzini, Capucine, additional, Laveneziana, Pierantonio, additional, Zysman, Maeva, additional, Blanchard, Elodie, additional, Raherison-Semjen, Chantal, additional, Giraud, Violaine, additional, Giroux-Leprieur, Etienne, additional, Habib, Stéfanie, additional, Roche, Nicolas, additional, Dinh-Xuan, Anh Tuan, additional, Sifaoui, Islem, additional, Brillet, Pierre-Yves, additional, Jung, Camille, additional, Boutin, Emmanuelle, additional, Layese, Richard, additional, Canoui-Poitrine, Florence, additional, and Maitre, Bernard, additional

Published
2023
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30. Efficacy of plasma exchange in patients with anti-MDA5 rapidly progressive interstitial lung disease

Author

Bay, Pierre, primary, de Chambrun, Marc Pineton, additional, Rothstein, Vincent, additional, Mahevas, Matthieu, additional, De Prost, Nicolas, additional, Roux, Antoine, additional, Zuber, Benjamin, additional, Biet, Dominique Israël, additional, Hervier, Baptiste, additional, Tazi, Abdellatif, additional, Mouthon, Luc, additional, Mekinian, Arsène, additional, Deligny, Christophe, additional, Borie, Raphaël, additional, Meurice, Jean Claude, additional, Meyer, Alain, additional, Priou, Pascaline, additional, Savale, Laurent, additional, De Saint Martin, Luc, additional, Gallay, Laure, additional, Cottin, Vincent, additional, Blanchard, Elodie, additional, Brillet, Pierre-Yves, additional, Khafagy, Philippe, additional, Benveniste, Olivier, additional, Nunes, Hilario, additional, Allenbach, Yves, additional, and Uzunhan, Yurdagül, additional

Published
2022
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33. Recommandations pratiques pour le diagnostic et la prise en charge de la fibrose pulmonaire idiopathique – Actualisation 2021. Version intégrale

Author

Cottin, Vincent, Bonniaud, Philippe, Cadranel, Jacques, Crestani, Bruno, Jouneau, Stéphane, Marchand-Adam, Sylvain, Nunes, Hilario, Wémeau-Stervinou, Lidwine, Bergot, Emmanuel, Blanchard, Elodie, Borie, Raphaël, Bourdin, Arnaud, Chenivesse, Cécile, Clément, Annick, Gomez, Emmanuel, Gondouin, Anne, Hirschi, Sandrine, Lebargy, François, Marquette, Charles-Hugo, Montani, David, Prévot, Grégoire, Quetant, Sébastien, Reynaud-Gaubert, Martine, Salaun, Mathieu, Sanchez, Olivier, Trumbic, Bruno, Berkani, Karim, Brillet, Pierre-Yves, Campana, Marion, Chalabreysse, Lara, Chatté, Gérard, Debieuvre, Didier, Ferretti, Gilbert, Fourrier, Jean-Michel, Just, Nicolas, Kambouchner, Marianne, Legrand, Bertrand, Le Guillou, Frédéric, Lhuillier, Jean-Pierre, Mehdaoui, Anas, Naccache, Jean-Marc, Paganon, Catherine, Rémy-Jardin, Martine, Si-Mohamed, Salim, Terrioux, Philippe, Infections Virales et Pathologie Comparée - UMR 754 (IVPC), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre national de référence des maladies pulmonaires rares [Lyon] (CRMPM), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service de Pneumologie Soins Intensifs, Appareillage Respiratoire [CHU de Dijon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Hôpital Avicenne [AP-HP], Institut Coeur Poumon [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU Pessac, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Maladies génétiques d'expression pédiatrique (U933), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Nouvel Hôpital Civil de Strasbourg, Centre Hospitalier Universitaire de Reims (CHU Reims), Hôpital Pasteur [Nice] (CHU), Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique, Centre Chirurgical Marie Lannelongue (CCML)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Universitaire [Grenoble] (CHU), CHU Marseille, Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Hypoxie et Poumon : pneumopathologies fibrosantes, modulations ventilatoires et circulatoires (H&P), UFR SMBH-Université Sorbonne Paris Nord, Centre Hospitalier Régional d'Orléans (CHRO), Hospices Civils de Lyon (HCL), Centre Hospitalier Emile Muller [Mulhouse] (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Eure-Seine - Hôpital d'Evreux - Vernon (Evreux), Groupe Hospitalier Paris Saint-Joseph (hpsj), Services de Pneumologie, Exploration Fonctionnelle Respiratoire et Cardiologie (Hôpital Louis Pradel), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Association pour l’amélioration de la prise en charge des maladies pulmonaires rares, Hospices Civils de Lyon, and Université Claude Bernard Lyon 1.

Subjects
Biopsy, Biopsie, [SDV]Life Sciences [q-bio], Fibrose pulmonaire, Pneumopathie interstitielle commune, Interstitial lung disease, Common interstitial lung disease, Pneumopathie interstitielle diffuse, Pulmonary fibrosis
Abstract

National audience; BACKGROUND: Since the previous French guidelines were published in 2017, substantial additional knowledge about idiopathic pulmonary fibrosis has accumulated. METHODS: Under the auspices of the French-speaking Learned Society of Pulmonology and at the initiative of the coordinating reference center, practical guidelines for treatment of rare pulmonary diseases have been established. They were elaborated by groups of writers, reviewers and coordinators with the help of the OrphaLung network, as well as pulmonologists with varying practice modalities, radiologists, pathologists, a general practitioner, a head nurse, and a patients’ association. The method was developed according to rules entitled "Good clinical practice" in the overall framework of the "Guidelines for clinical practice" of the official French health authority (HAS), taking into account the results of an online vote using a Likert scale. RESULTS: After analysis of the literature, 54 recommendations were formulated, improved, and validated by the working groups. The recommendations covered a wide-ranging aspects of the disease and its treatment: epidemiology, diagnostic modalities, quality criteria and interpretation of chest CT, indication and modalities of lung biopsy, etiologic workup, approach to familial disease entailing indications and modalities of genetic testing, evaluation of possible functional impairments and prognosis, indications for and use of antifibrotic therapy, lung transplantation, symptom management, comorbidities and complications, treatment of chronic respiratory failure, diagnosis and management of acute exacerbations of fibrosis. CONCLUSION: These evidence-based guidelines are aimed at guiding the diagnosis and the management in clinical practice of idiopathic pulmonary fibrosis.; Contexte :Depuis les précédentes recommandations françaises publiées en 2017, les connaissances concernant la fibrose pulmonaire idiopathique ont évolué sur de nombreux aspects.Méthodes :Des recommandations pratiques ont été établies à l’initiative du Centre coordonnateur de référence des maladies pulmonaires rares, sous l’égide de la Société de Pneumologie de Langue Française, par un groupe de coordination, un groupe de rédaction, et un groupe de lecture, impliquant l’ensemble du réseau OrphaLung, des pneumologues de divers modes d’exercice, des radiologues, des pathologistes, un médecin généraliste, un cadre de santé, et une association de patients. La méthode a respecté les règles d’élaboration des « Bonnes pratiques cliniques » selon la méthode des « Recommandations pour la pratique clinique » de la Haute Autorité de Santé, incluant un vote en ligne selon une échelle Likert.Résultats :Après une analyse bibliographique, 54 recommandations ont été formulées, améliorées, puis validées par les groupes de travail, portant sur des aspects multiples de la maladie : épidémiologie, modalités diagnostiques, critères de qualité et interprétation du scanner thoracique, indication et réalisation de la biopsie pulmonaire, bilan étiologique, modalités et indications de l’enquête familiale et de l’analyse génétique, évaluation du retentissement fonctionnel et du pronostic, indication et emploi des médicaments antifibrosants, transplantation pulmonaire, prise en charge des symptômes, comorbidités et complications, traitement de l’insuffisance respiratoire chronique, diagnostic et prise en charge des exacerbations aiguës de fibrose.Conclusion :Ces recommandations fondées sur les preuves sont destinées à guider le diagnostic et la prise en charge pratique de la fibrose pulmonaire idiopathique.

Published
2022
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37. Interstitial lung diseases associated with mutations of poly(A)-specific ribonuclease: A multicentre retrospective study

Author

Philippot, Quentin, Kannengiesser, Caroline, Debray, Marie Pierre, Gauvain, Clément, Ba, Ibrahima, Vieri, Margherita, Gondouin, Anne, Naccache, Jean Marc, Reynaud-Gaubert, Martine, Uzunhan, Yurdagul, Bondue, Benjamin, Israël-Biet, Dominique, Dieudé, Philippe, Fourrage, Cécile, Lainey, Elodie, Manali, Effrosyne, Papiris, Spyridon, Wemeau, Lidwine, Hirschi, Sandrine, Mal, Hervé, Nunes, Hilario, Schlemmer, Frédéric, Blanchard, Elodie, Beier, Fabian, Cottin, Vincent, Crestani, Bruno, Borie, Raphael, Philippot, Quentin, Kannengiesser, Caroline, Debray, Marie Pierre, Gauvain, Clément, Ba, Ibrahima, Vieri, Margherita, Gondouin, Anne, Naccache, Jean Marc, Reynaud-Gaubert, Martine, Uzunhan, Yurdagul, Bondue, Benjamin, Israël-Biet, Dominique, Dieudé, Philippe, Fourrage, Cécile, Lainey, Elodie, Manali, Effrosyne, Papiris, Spyridon, Wemeau, Lidwine, Hirschi, Sandrine, Mal, Hervé, Nunes, Hilario, Schlemmer, Frédéric, Blanchard, Elodie, Beier, Fabian, Cottin, Vincent, Crestani, Bruno, and Borie, Raphael

Abstract

Background and objective: Poly(A)-specific ribonuclease (PARN) mutations have been associated with familial pulmonary fibrosis. This study aims to describe the phenotype of patients with interstitial lung disease (ILD) and heterozygous PARN mutations. Methods: We performed a retrospective, observational, non-interventional study of patients with an ILD diagnosis and a pathogenic heterozygous PARN mutation followed up in a centre of the OrphaLung network. Results: We included 31 patients (29 from 16 kindreds and two sporadic patients). The median age at ILD diagnosis was 59 years (range 54 to 63). In total, 23 (74%) patients had a smoking history and/or fibrogenic exposure. The pulmonary phenotypes were heterogenous, but the most frequent diagnosis was idiopathic pulmonary fibrosis (n = 12, 39%). Haematological abnormalities were identified in three patients and liver disease in two. In total, 21 patients received a specific treatment for ILD: steroids (n = 13), antifibrotic agents (n = 11), immunosuppressants (n = 5) and N-acetyl cysteine (n = 2). The median forced vital capacity decline for the whole sample was 256 ml/year (range −363 to −148). After a median follow-up of 32 months (range 18 to 66), 10 patients had died and six had undergone lung transplantation. The median transplantation-free survival was 54 months (95% CI 29 to ∞). Extra-pulmonary features were less frequent with PARN mutation than telomerase reverse transcriptase (TERT) or telomerase RNA component (TERC) mutation. Conclusion: IPF is common among individuals with PARN mutation, but other ILD subtypes may be observed., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

39. RCT Abstract - Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomized, double-blind, placebo-controlled, phase 3 trial

Author

Naccache, Jean-Marc, primary, Jouneau, Stephane, additional, Didier, Morgane, additional, Borie, Raphaël, additional, Cachanado, Marine, additional, Bourdin, Arnaud, additional, Reynaud-Gaubert, Martine, additional, Bonniaud, Philippe, additional, Israel-Biet, Dominique, additional, Prevot, Gregoire, additional, Hirschi, Sandrine, additional, Lebargy, Francois, additional, Marchand-Adam, Sylvain, additional, Bautin, Nathalie, additional, Traclet, Julie, additional, Gomez, Emmanuel, additional, Leroy, Sylvie, additional, Gagnadoux, Frederic, additional, Rivière, Frederic, additional, Bergot, Emmanuel, additional, Gondouin, Anne, additional, Blanchard, Elodie, additional, Parrot, Antoine, additional, Blanc, Francois-Xavier, additional, Chabrol, Alexandre, additional, Dominique, Stephane, additional, Gibelin, Aude, additional, Tazi, Abdellatif, additional, Berard, Laurence, additional, Brillet, Pierre-Yves, additional, Debray, Marie-Pierre, additional, Rousseau, Alexandra, additional, Kerjouan, Malorie, additional, Freynet, Olivia, additional, Dombret, Marie-Christine, additional, Gamez, Anne-Sophie, additional, Nieves, Ana, additional, Beltramo, Guillaume, additional, Pastré, Jean, additional, Le Borgne-Krams, Aurélie, additional, Dégot, Tristan, additional, Launois, Claire, additional, Plantier, Laurent, additional, Wémeau-Stervinou, Lidwine, additional, Cadranel, Jacques, additional, Chenivesse, Cécile, additional, Valeyre, Dominique, additional, Crestani, Bruno, additional, Cottin, Vincent, additional, Simon, Tabassome, additional, and Nunes, Hilario, additional

Published
2021
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42. Safety and efficacy of pirfenidone and nintedanib in patients with idiopathic pulmonary fibrosis and carrying a telomere-related gene mutation

Author

Justet, Aurelien Klay, Dymph Porcher, Raphael Cottin, Vincent Ahmad, Kais Molina, Maria Molina Nunes, Hilario and Reynaud-Gaubert, Martine Naccache, Jean Marc Manali, Effrosyni and Froidure, Antoine Jouneau, Stephane Wemeau, Lidwine and Andrejak, Claire Gondouin, Anne Hirschi, Sandrine Blanchard, Elodie Bondue, Benjamin Bonniaud, Philippe Tromeur, Cecile and Prevot, Gregoire Marchand-Adam, Sylvain Funke-Chambour, Manuela Gamez, Anne Sophie Ba, Ibrahima Papiris, Spyridon and Grutters, Jan Crestani, Bruno van Moorsel, Coline and Kannengiesser, Caroline Borie, Raphael OrphaLung Network

Published
2021

43. Additional file 1 of Management of patients with pulmonary mycobacteriosis in France: a multicenter retrospective cohort study

Author

Bemer, Pascale, Peuchant, Olivia, Guet-Revillet, Hélène, Bador, Julien, Balavoine, Charlotte, Basille, Damien, Beltramo, Guillaume, Blanc, François-Xavier, Blanchard, Elodie, Boulanger, Sarah, Bourgoin, Anne, Boutoille, David, Cambau, Emmanuelle, Canis, Frédérique, Caparros, Didier, Carricajo, Anne, Carrière, Christian, Couetdic, Gérard, Couturaud, Francis, Dalphin, Jean-Charles, Degot, Tristan, Desquiens, Marion, Devouassoux, Gilles, Duez, Jean-Marie, Dumitrescu, Oana, Dupuy-Grasset, Magali, Gaudart, Alice, Georges, Marjolaine, Godet, Cendrine, Godreuil, Sylvain, Guillouzouic, Aurélie, Hamdad-Daoudi, Farida, Héry-Arnaud, Geneviève, Koebel, Christelle, Lagrange, Aurore, Lanotte, Philippe, Marchand-Adam, Sylvain, Mougari, Faïza, Murris, Marlène, Patry, Isabelle, Pérouse de Montclos, Michèle, Raskine, Laurent, Risso, Karine, Segonds, Christine, Sicard, Dominique, Terru, Dominique, Vachée, Anne, Vergnon, Jean-Michel, Martin, Christian, Schramm, Frédéric, and Andrejak, Claire

Abstract

Additional file 1. Guide to fulfill CRF.

Published
2021
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44. Nebulised liposomal-amphotericin-B as maintenance therapy in ABPA: a randomised, multicentre, trial

Author

Godet, Cendrine, Couturaud, Francis, Marchand-Adam, Sylvain, Pison, Christophe, Gagnadoux, Frédéric, Blanchard, Elodie, Taillé, Camille, Philippe, Bruno, Hirschi, Sandrine, Andréjak, Claire, Bourdin, Arnaud, Chenivesse, Cécile, Dominique, Stéphane, Bassinet, Laurence, Murris-Espin, Marlène, Rivière, Frédéric, Garcia, Gilles, Caillaud, Denis, Blanc, François-Xavier, Goupil, François, Bergeron, Anne, Gondouin, Anne, Frat, Jean-Pierre, Flament, Thomas, Camara, Boubou, Priou, Pascaline, Brun, Anne-Laure, Laurent, François, Ragot, Stéphanie, Cadranel, Jacques, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience; Background In allergic bronchopulmonary aspergillosis (ABPA), prolonged nebulised antifungal treatment may be a strategy for maintaining remission. Methods We performed a randomised, single-blind, clinical trial in 30 centres. Patients with controlled ABPA after a 4-month attack treatment (corticosteroids and itraconazole) were randomly assigned to nebulised liposomal-amphotericin-B or placebo for 6 months. The primary outcome was occurrence of a first severe clinical exacerbation within 24 months following randomisation. Secondary outcomes included the median time-to-first severe clinical exacerbation, number of severe clinical exacerbations per patient, ABPA-related biological parameters. Results Among 174 enrolled patients with ABPA from March 2015 through July 2017, 139 were controlled after 4-month attack treatment and were randomised. The primary outcome occurred in 33 (50.8%) of 65 patients in nebulised liposomal-amphotericin-B group and 38 (51.3%) of 74 in placebo group (absolute difference −0.6%, 95% CI −16.8% to +15.6%, odds ratio 0.98, 95% CI 0.50 to 1.90; p=0.95). The median time-to-first severe clinical exacerbation was longer in liposomal-amphotericin-B group, 337 days (IQR, 168 to 476) versus 177 (64 to 288). At the end of maintenance therapy, total immunoglobulin-E and Aspergillus precipitins were significantly decreased in nebulised liposomal-amphotericin-B group. Conclusions In ABPA, maintenance therapy using nebulised liposomal-amphotericin-B did not reduce the risk of severe clinical exacerbation. The presence of some positive secondary outcomes creates clinical equipoise for further research.

Published
2021
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45. Safety and efficacy of pirfenidone and nintedanib in patients with idiopathic pulmonary fibrosis and carrying a telomere-related gene mutation.

Author

UCL - (SLuc) Service de pneumologie, Justet, Aurélien, Klay, Dymph, Porcher, Raphaël, Cottin, Vincent, Ahmad, Kais, Molina Molina, Maria, Nunes, Hilario, Reynaud-Gaubert, Martine, Naccache, Jean Marc, Manali, Effrosyni, Froidure, Antoine, Jouneau, Stéphane, Wemeau, Lidwine, Andrejak, Claire, Gondouin, Anne, Hirschi, Sandrine, Blanchard, Elodie, Bondue, Benjamin, Bonniaud, Philippe, Tromeur, Cécile, Prévot, Grégoire, Marchand-Adam, Sylvain, Funke-Chambour, Manuela, Gamez, Anne Sophie, Ba, Ibrahima, Papiris, Spyridon, Grutters, Jan, Crestani, Bruno, van Moorsel, Coline, Kannengiesser, Caroline, Borie, Raphaël, OrphaLung Network, UCL - (SLuc) Service de pneumologie, Justet, Aurélien, Klay, Dymph, Porcher, Raphaël, Cottin, Vincent, Ahmad, Kais, Molina Molina, Maria, Nunes, Hilario, Reynaud-Gaubert, Martine, Naccache, Jean Marc, Manali, Effrosyni, Froidure, Antoine, Jouneau, Stéphane, Wemeau, Lidwine, Andrejak, Claire, Gondouin, Anne, Hirschi, Sandrine, Blanchard, Elodie, Bondue, Benjamin, Bonniaud, Philippe, Tromeur, Cécile, Prévot, Grégoire, Marchand-Adam, Sylvain, Funke-Chambour, Manuela, Gamez, Anne Sophie, Ba, Ibrahima, Papiris, Spyridon, Grutters, Jan, Crestani, Bruno, van Moorsel, Coline, Kannengiesser, Caroline, Borie, Raphaël, and OrphaLung Network

Abstract

No abstract available

Published
2021

46. Lung transplantation for sarcoidosis:Outcome and prognostic factors

Author

Le Pavec, Jérôme, Valeyre, Dominique, Gazengel, Pierre, Holm, Are M., Schultz, Hans Henrik, Perch, Michael, Le Borgne, Aurélie, Reynaud-Gaubert, Martine, Knoop, Christiane, Godinas, Laurent, Hirschi, Sandrine, Bunel, Vincent, Laporta, Rosalia, Harari, Sergio, Blanchard, Elodie, Magnusson, Jesper M., Tissot, Adrien, Mornex, Jean François, Picard, Clément, Savale, Laurent, Bernaudin, Jean François, Brillet, Pierre Yves, Nunes, Hilario, Humbert, Marc, Fadel, Elie, Gottlieb, Jens, Le Pavec, Jérôme, Valeyre, Dominique, Gazengel, Pierre, Holm, Are M., Schultz, Hans Henrik, Perch, Michael, Le Borgne, Aurélie, Reynaud-Gaubert, Martine, Knoop, Christiane, Godinas, Laurent, Hirschi, Sandrine, Bunel, Vincent, Laporta, Rosalia, Harari, Sergio, Blanchard, Elodie, Magnusson, Jesper M., Tissot, Adrien, Mornex, Jean François, Picard, Clément, Savale, Laurent, Bernaudin, Jean François, Brillet, Pierre Yves, Nunes, Hilario, Humbert, Marc, Fadel, Elie, and Gottlieb, Jens

Abstract

Study question In patients with sarcoidosis, past and ongoing immunosuppressive regimens, recurrent disease in the transplant and extrapulmonary involvement may affect outcomes of lung transplantation. We asked whether sarcoidosis lung phenotypes can be differentiated and, if so, how they relate to outcomes in patients with pulmonary sarcoidosis treated by lung transplantation. Patients and methods We retrospectively reviewed data from 112 patients who met international diagnostic criteria for sarcoidosis and underwent lung or heart-lung transplantation between 2006 and 2019 at 16 European centres. Results Patient survival was the main outcome measure. At transplantation, median (interaquartile range (IQR)) age was 52 (46-59) years; 71 (64%) were male. Lung phenotypes were individualised as follows: 1) extended fibrosis only; 2) airflow obstruction; 3) severe pulmonary hypertension (sPH) and airflow obstruction; 4) sPH, airflow obstruction and fibrosis; 5) sPH and fibrosis; 6) airflow obstruction and fibrosis; 7) sPH; and 8) none of these criteria, in 17%, 16%, 17%, 14%, 11%, 9%, 5% and 11% of patients, respectively. Post-transplant survival rates after 1, 3, and 5 years were 86%, 76% and 69%, respectively. During follow-up (median (IQR) 46 (16-89) months), 31% of patients developed chronic lung allograft dysfunction. Age and extended lung fibrosis were associated with increased mortality. Pulmonary fibrosis predominating peripherally was associated with short-term complications. Answer to the study question Post-transplant survival in patients with pulmonary sarcoidosis was similar to that in patients with other indications for lung transplantation. The main factors associated with worse survival were older age and extensive pre-operative lung fibrosis.

Published
2021

47. Lung transplantation for sarcoidosis: Outcome and prognostic factors

Author

Le Pavec, Jérôme, Valeyre, D., Gazengel, Pierre, Holm, Are Martin, Schultz, Hans Henrik, Perch, Michael, Le Borgne, Aurélie, Reynaud-Gaubert, Martine, Knoop, Christiane, Godinas, Laurent, Hirschi, Sandrine, Bunel, Vincent, Laporta, Rosalia, Harari, Sergio, Blanchard, Elodie, Magnusson, Jesper, Tissot, Adrien, Mornex, Jean-François, Picard, Clément, Savale, Laurent, Bernaudin, Jean François, Brillet, Pierre Yves, Nunes, Hilario, Humbert, Marc, Fadel, Élie, Gottlieb, Jens, Le Pavec, Jérôme, Valeyre, D., Gazengel, Pierre, Holm, Are Martin, Schultz, Hans Henrik, Perch, Michael, Le Borgne, Aurélie, Reynaud-Gaubert, Martine, Knoop, Christiane, Godinas, Laurent, Hirschi, Sandrine, Bunel, Vincent, Laporta, Rosalia, Harari, Sergio, Blanchard, Elodie, Magnusson, Jesper, Tissot, Adrien, Mornex, Jean-François, Picard, Clément, Savale, Laurent, Bernaudin, Jean François, Brillet, Pierre Yves, Nunes, Hilario, Humbert, Marc, Fadel, Élie, and Gottlieb, Jens

Abstract

Study question In patients with sarcoidosis, past and ongoing immunosuppressive regimens, recurrent disease in the transplant and extrapulmonary involvement may affect outcomes of lung transplantation. We asked whether sarcoidosis lung phenotypes can be differentiated and, if so, how they relate to outcomes in patients with pulmonary sarcoidosis treated by lung transplantation. Patients and methods We retrospectively reviewed data from 112 patients who met international diagnostic criteria for sarcoidosis and underwent lung or heart-lung transplantation between 2006 and 2019 at 16 European centres. Results Patient survival was the main outcome measure. At transplantation, median (interaquartile range (IQR)) age was 52 (46-59) years; 71 (64%) were male. Lung phenotypes were individualised as follows: 1) extended fibrosis only; 2) airflow obstruction; 3) severe pulmonary hypertension (sPH) and airflow obstruction; 4) sPH, airflow obstruction and fibrosis; 5) sPH and fibrosis; 6) airflow obstruction and fibrosis; 7) sPH; and 8) none of these criteria, in 17%, 16%, 17%, 14%, 11%, 9%, 5% and 11% of patients, respectively. Post-transplant survival rates after 1, 3, and 5 years were 86%, 76% and 69%, respectively. During follow-up (median (IQR) 46 (16-89) months), 31% of patients developed chronic lung allograft dysfunction. Age and extended lung fibrosis were associated with increased mortality. Pulmonary fibrosis predominating peripherally was associated with short-term complications. Answer to the study question Post-transplant survival in patients with pulmonary sarcoidosis was similar to that in patients with other indications for lung transplantation. The main factors associated with worse survival were older age and extensive pre-operative lung fibrosis., SCOPUS: re.j, info:eu-repo/semantics/published

Published
2021

48. Safety and efficacy of pirfenidone and nintedanib in patients with idiopathic pulmonary fibrosis and carrying a telomere-related gene mutation.

Author

Justet, Aurélien, Klay, Dymph, Porcher, Raphaël, Cottin, Vincent, Ahmad, Kais, Molina Molina, Maria, Nunes, Hilario, Reynaud-Gaubert, Martine, Naccache, Jean Marc, Manali, Effrosyni E.D., Froidure, Antoine, Jouneau, Stéphane, Stervinou-Wemeau, Lidwine, Andrejak, Claire, Gondouin, Anne, Hirschi, Sandrine, Blanchard, Elodie, Bondue, Benjamin, Bonniaud, Philippe, Tromeur, Cécile, Prévot, Grégoire, Marchand-Adam, Sylvain, Funke-Chambour, Manuela, Gamez, Anne Sophie, Ba, Ibrahima, Papiris, Spyridon, Grutters, Jan JC, Crestani, Bruno, Van Moorsel, Coline, Kannengiesser, Caroline, Borie, Raphael, OrphaLung Network, Justet, Aurélien, Klay, Dymph, Porcher, Raphaël, Cottin, Vincent, Ahmad, Kais, Molina Molina, Maria, Nunes, Hilario, Reynaud-Gaubert, Martine, Naccache, Jean Marc, Manali, Effrosyni E.D., Froidure, Antoine, Jouneau, Stéphane, Stervinou-Wemeau, Lidwine, Andrejak, Claire, Gondouin, Anne, Hirschi, Sandrine, Blanchard, Elodie, Bondue, Benjamin, Bonniaud, Philippe, Tromeur, Cécile, Prévot, Grégoire, Marchand-Adam, Sylvain, Funke-Chambour, Manuela, Gamez, Anne Sophie, Ba, Ibrahima, Papiris, Spyridon, Grutters, Jan JC, Crestani, Bruno, Van Moorsel, Coline, Kannengiesser, Caroline, Borie, Raphael, and OrphaLung Network

Abstract

SCOPUS: le.j, info:eu-repo/semantics/published

Published
2021

49. Mangroves: a natural early warning system of erosion of open muddy coasts in French Guiana

Author

Proisy, Christophe, Wackler, Romain, Blanchard, Elodie, gardel, antoine, Anthony, Edward J., Botanique et Modélisation de l'Architecture des Plantes et des Végétations (UMR AMAP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire Ecologie Fonctionnelle et Environnement (ECOLAB), Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Institut Agronomique Néo-Calédonien (IAC), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Daniel Friess, Frida Sidik, Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut Ecologie et Environnement (INEE), and Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)

Subjects
[SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, Mud-bank migration, Mud bank, Dynamics of mangrove, [SDE]Environmental Sciences, Mud dynamics, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Mangrove, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, ComputingMilieux_MISCELLANEOUS, French Guiana
Abstract

International audience

Published
2020

50. Lung transplantation for sarcoidosis: outcome and prognostic factors

Author

Le Pavec, Jérôme, primary, Valeyre, Dominique, additional, Gazengel, Pierre, additional, Holm, Are M., additional, Schultz, Hans Henrik, additional, Perch, Michael, additional, Le Borgne, Aurélie, additional, Reynaud-Gaubert, Martine, additional, Knoop, Christiane, additional, Godinas, Laurent, additional, Hirschi, Sandrine, additional, Bunel, Vincent, additional, Laporta, Rosalia, additional, Harari, Sergio, additional, Blanchard, Elodie, additional, Magnusson, Jesper M., additional, Tissot, Adrien, additional, Mornex, Jean-François, additional, Picard, Clément, additional, Savale, Laurent, additional, Bernaudin, Jean-François, additional, Brillet, Pierre-Yves, additional, Nunes, Hilario, additional, Humbert, Marc, additional, Fadel, Elie, additional, and Gottlieb, Jens, additional

Published
2021
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