1. SEOM-GEINO clinical guideline of systemic therapy and management of brain central nervous system metastases (2021)
- Author
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María Martínez-García, Sonia Servitja Tormo, Noelia Vilariño Quintela, Ana Arance Fernández, Alfonso Berrocal Jaime, Blanca Cantos Sánchez de Ibargüen, Sonia Del Barco Berrón, Rosario García Campelo, Regina Gironés Sarrió, and Juan Manuel Sepúlveda-Sánchez
- Subjects
Central Nervous System ,Cancer Research ,Lung Neoplasms ,Brain Neoplasms ,Brain metastasis ,Brain ,Neoplasms, Second Primary ,General Medicine ,Guidelines ,Blood–brain barrier, Brain metastasis, Guidelines, Immunotherapy, Targeted therapies ,Central Nervous System Neoplasms ,Blood–brain barrier ,Targeted therapies ,Oncology ,Humans ,Immunotherapy ,Melanoma - Abstract
Central nervous system (CNS) dissemination is a severe complication in cancer and a leading cause of cancer-related mortality. Brain metastases (BMs) are the most common types of malignant intracranial tumors and are reported in approximately 25% of patients with metastatic cancers. The recent increase in incidence of BMs is due to several factors including better diagnostic assessments and the development of improved systemic therapies that have lower activity on the CNS. However, newer systemic therapies are being developed that can cross the blood–brain barrier giving us additional tools to treat BMs. The guidelines presented here focus on the efficacy of new targeted systemic therapies and immunotherapies on CNS BMs from breast, melanoma, and lung cancers.
- Published
- 2022
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