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Comprehensive CA-CP Study Group: Ingeborg Barisic, Vlatka Bosnjak Mejaski, Emmanuelle Amar, Elodie Sellier, Sandra Julsen Hollung, Kari Klungsøyr, Paula Braz, Daniel Virella, Catherine Gibson, Karin Källén, Susan M Reid, Gareth Baynam, Dylan Gration, Michèle Hansen, Linda Watson Comprehensive CA-CP Study Group: Paula Braz, Daniel Virella. INSA, Portugal. Aim: To describe the major congenital anomalies present in children with postneonatally acquired cerebral palsy (CP), and to compare clinical outcomes and cause of postneonatally acquired CP between children with and without anomalies. Method: Data were linked between total population CP and congenital anomaly registers in five European and three Australian regions for children born 1991 to 2009 (n=468 children with postneonatally acquired CP; 255 males, 213 females). Data were pooled and children classified into mutually exclusive categories based on type of congenital anomaly. The proportion of children with congenital anomalies was calculated. Clinical outcomes and cause of postneonatally acquired CP were compared between children with and without anomalies. Results: Major congenital anomalies were reported in 25.6% (95% confidence interval [CI] 21.7-29.9) of children with postneonatally acquired CP. Cardiac anomalies, often severe, were common and present in 14.5% of children with postneonatally acquired CP. Clinical outcomes were not more severe in children with congenital anomalies than those without anomalies. Cause of postneonatally acquired CP differed with the presence of congenital anomalies, with cerebrovascular accidents predominating in the anomaly group. Congenital anomalies were likely associated with cause of postneonatally acquired CP in 77% of children with anomalies. Interpretation: In this large, international study of children with postneonatally acquired CP, congenital anomalies (particularly cardiac anomalies) were common. Future research should determine specific causal pathways to postneonatally acquired CP that include congenital anomalies to identify opportunities for prevention. What this paper adds: One-quarter of children with postneonatally acquired cerebral palsy (CP) have a major congenital anomaly. Cardiac anomalies, often severe, are the most common anomalies. Causes of postneonatally acquired CP differ between children with and without congenital anomalies. Objetivo: Describir las principales anomalías congenitas presentes en niños con parálisis cerebral (PC) adquirida posnatalmente y comparar los resultados clínicos y la causa de PC entre niños con y sin anomalías. Método: Se relacionaron los registros de datos de la población con PC y los registros de anomalías congenitas de cinco regiones de Europa y tres de Australia de niños nacidos de 1991 a 2009 (n = 468 niños con PC adquirida posnatalmente; 255 varones, 213 mujeres). Se agruparon los datos y clasificaron en categor ıas mutuamente excluyentes segun el tipo de anomalías congenita. Se calcul o la pro-porcion de ni nos con anomalías congenitas. Se compararon los resultados clínicos y la causa de la PC adquirida posnatalmente entre niños con y sin anomalías. Resultados: Se registraron anomalías congenitas importantes en el 25,6% (intervalo de confianza [IC] del 95%: 21,7-29,9) de los niños con PC adquirida despues del nacimiento. Hubo una alta frecuencia de anomalías cardíacas, que estaban presentes en el 14,5% de los niños con PC adquirida posnatalmente. La evolución clínica no fue diferentes entre niños con o sin anomalías congenitas. La causa de PC adquirida posnatalmente vario con la presencia de anomalías congenitas, predominando los accidentes cerebrovasculares en el grupo de anomalías congenitas. La causa de PC adquirida posnatalmente esta probablemente asociada con anomalias congenitas en el 77% de los niños con anomalías. Interpretacion: En este estudio internacional de niños con PC adquirida posnatalmente, las anomalías congenitas fueron frecuentes, particularmente las anomalías cardíacas. Las investigaciones futuras deben determinar las vías causales específicas de la PC adquirida posnatalmente que incluyen anomalías congenitas para identificar oportunidades de prevención. info:eu-repo/semantics/publishedVersion