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205 results on '"Bjørnebekk, Astrid"'

16. ExploreASL: An image processing pipeline for multi-center ASL perfusion MRI studies

Author

Mutsaerts, Henk J.M.M., Petr, Jan, Groot, Paul, Vandemaele, Pieter, Ingala, Silvia, Robertson, Andrew D., Václavů, Lena, Groote, Inge, Kuijf, Hugo, Zelaya, Fernando, O’Daly, Owen, Hilal, Saima, Wink, Alle Meije, Kant, Ilse, Caan, Matthan W.A., Morgan, Catherine, de Bresser, Jeroen, Lysvik, Elisabeth, Schrantee, Anouk, Bjørnebekk, Astrid, Clement, Patricia, Shirzadi, Zahra, Kuijer, Joost P.A., Wottschel, Viktor, Anazodo, Udunna C., Pajkrt, Dasja, Richard, Edo, Bokkers, Reinoud P.H., Reneman, Liesbeth, Masellis, Mario, Günther, Matthias, MacIntosh, Bradley J., Achten, Eric, Chappell, Michael A., van Osch, Matthias J.P., Golay, Xavier, Thomas, David L., De Vita, Enrico, Bjørnerud, Atle, Nederveen, Aart, Hendrikse, Jeroen, Asllani, Iris, and Barkhof, Frederik

Published
2020
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18. Off-label use of Clomiphene citrate to Treat Anabolic-androgenic Steroid induced Hypogonadism upon cessation among men (CloTASH) - a pilot study protocol

Author

Havnes, Ingrid Amalia, primary, Henriksen, Hans Christian Bordado, additional, Johansen, Per Wiik, additional, Bjørnebekk, Astrid, additional, Neupane, Sudan Prasad, additional, Hisdal, Jonny, additional, Seljeflot, Ingebjørg, additional, Wisløff, Christine, additional, Jørstad, Marie Lindvik, additional, McVeigh, Jim, additional, and Jørgensen, Anders Palmstrøm, additional

Published
2024
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19. Treatment‐seeking behavior and cardiovascular morbidity among men with anabolic‐androgenic steroid use: A cross‐sectional study

Author

Henriksen, Hans Christian Bordado, primary, Havnes, Ingrid Amalia, additional, Jørstad, Marie Lindvik, additional, Abdullah, Rang, additional, Thorsby, Per Medbøe, additional, Hauger, Lisa Evju, additional, Edvardsen, Thor, additional, Haugaa, Kristina H., additional, Almaas, Vibeke Marie, additional, and Bjørnebekk, Astrid, additional

Published
2024
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32. Reduced arterial elasticity after anabolic–androgenic steroid use in young adult males and mice

Author

Melsom, Helene Støle, Heiestad, Christina Mathisen, Eftestøl, Einar, Torp, May-Kristin, Gundersen, Kristian, Bjørnebekk, Astrid, Thorsby, Per Medbøe, Stensløkken, Kåre-Olav, and Hisdal, Jonny

Subjects
Male, Mice, Carotid Arteries, Multidisciplinary, Animals, Female, Testosterone, Pulse Wave Analysis, Carotid Intima-Media Thickness, Elasticity
Abstract

High-doses of anabolic–androgenic steroids (AAS) is efficient for building muscle mass, but pose a risk of cardiovascular side effects. Little is known of the effect of AAS on vasculature, but previous findings suggest unfavorable alterations in vessel walls and vasoreactivity. Here, long-term effect of AAS on vascular function and morphology were examined in male weightlifters, and in a mimicking animal model. Arterial elasticity and morphology were tested with ultrasound, pulse wave velocity (PWV) and carotid intima media thickness (cIMT) in 56 current male AAS users, and 67 non-exposed weightlifting controls (WLC). Female mice were treated with testosterone for 14 days and echocardiography were applied to evaluate vascular function and morphology. Male AAS users had higher PWV (p = 0.044), reduced carotid artery compliance (p = 0.0005), and increased cIMT (p = 0.041) compared to WLC. Similar functional changes were found in the ascending aorta of mice after 7- (p = 0.043) and 14 days (p = 0.001) of testosterone treatment. This animal model can be used to map molecular mechanisms responsible for complications related to AAS misuse. Considering the age-independent stiffening of major arteries and the predictive power of an increase in PWV and cIMT, the long-term users of AAS are at increased risk of severe cardiovascular events.

Published
2022

37. Use of High-Dose Androgens Is Associated with Reduced Brain-Derived Neurotrophic Factor in Male Weightlifters.

Author

Bjørnebekk, Astrid, Scarth, Morgan, Neupane, Sudan Prasad, Westlye, Lars T., Hullstein, Ingunn R., Thorsby, Per Medbøe, and Halvorsen, Bente

Subjects
*BRAIN-derived neurotrophic factor, *SEX hormones, *ANDROGENS, *RESISTANCE training, *WEIGHT lifters
Abstract

Introduction: Use of high-dose androgens causes drastic changes in hormonal milieu and is associated with adverse medical, psychological, and cognitive effects. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family of growth factors plays a critical role in neuroplasticity, with implications for cognitive function and mental health. The impact of long-term, high-dose androgen use on BDNF in a natural setting has not been investigated. This study examined the association between long-term androgen exposure and BDNF levels, and the links between BDNF, heavy resistance exercise, hormones, androgens, and mental health. Methods: We measured serum levels of BDNF and sex steroid hormones in male weightlifters (N = 141) with a history of current (n = 59), past (n = 29), or no (n = 52) androgen use. All participants completed questionnaires assessing maximum strength and measures of anxiety and depression. Group differences in BDNF were tested using general linear models adjusting for age and associations between BDNF and strength, anxiety, and depression using Pearson's or Kendall's correlations. Results: Both current (mean: 44.1 ng/mL [SD: 12.7]) and past (39.5 ng/mL [SD: 13.9]) androgen users showed lower serum BDNF levels compared to nonusing controls (51.5 [SD: 15.3], p < 0.001, ηp2 = 0.10). BDNF levels were negatively related to maximal strength, and with hormonal status in past androgen users, but no significant associations were found with measures of depression and anxiety. Conclusion: Lower circulating BDNF concentrations in current and past androgen users suggest that high-dose androgen exposure triggers persistent changes in BDNF expression. Further studies are needed to verify the relationship and its potential clinical implications. [ABSTRACT FROM AUTHOR]

Published
2023
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41. ExploreASL: An image processing pipeline for multi-center ASL perfusion MRI studies

Author

Researchgr. Neuroradiologie, Beeldverwerking ISI, Brain, Cancer, Researchgr. Systems Radiology, MS Radiologie, Mutsaerts, Henk J M M, Petr, Jan, Groot, Paul, Vandemaele, Pieter, Ingala, Silvia, Robertson, Andrew D, Václavů, Lena, Groote, Inge, Kuijf, Hugo, Zelaya, Fernando, O'Daly, Owen, Hilal, Saima, Wink, Alle Meije, Kant, Ilse, Caan, Matthan W A, Morgan, Catherine, de Bresser, Jeroen, Lysvik, Elisabeth, Schrantee, Anouk, Bjørnebekk, Astrid, Clement, Patricia, Shirzadi, Zahra, Kuijer, Joost P A, Wottschel, Viktor, Anazodo, Udunna C, Pajkrt, Dasja, Richard, Edo, Bokkers, Reinoud P H, Reneman, Liesbeth, Masellis, Mario, Günther, Matthias, MacIntosh, Bradley J, Achten, Eric, Chappell, Michael A, van Osch, Matthias J P, Golay, Xavier, Thomas, David L, De Vita, Enrico, Bjørnerud, Atle, Nederveen, Aart, Hendrikse, Jeroen, Asllani, Iris, Barkhof, Frederik, Researchgr. Neuroradiologie, Beeldverwerking ISI, Brain, Cancer, Researchgr. Systems Radiology, MS Radiologie, Mutsaerts, Henk J M M, Petr, Jan, Groot, Paul, Vandemaele, Pieter, Ingala, Silvia, Robertson, Andrew D, Václavů, Lena, Groote, Inge, Kuijf, Hugo, Zelaya, Fernando, O'Daly, Owen, Hilal, Saima, Wink, Alle Meije, Kant, Ilse, Caan, Matthan W A, Morgan, Catherine, de Bresser, Jeroen, Lysvik, Elisabeth, Schrantee, Anouk, Bjørnebekk, Astrid, Clement, Patricia, Shirzadi, Zahra, Kuijer, Joost P A, Wottschel, Viktor, Anazodo, Udunna C, Pajkrt, Dasja, Richard, Edo, Bokkers, Reinoud P H, Reneman, Liesbeth, Masellis, Mario, Günther, Matthias, MacIntosh, Bradley J, Achten, Eric, Chappell, Michael A, van Osch, Matthias J P, Golay, Xavier, Thomas, David L, De Vita, Enrico, Bjørnerud, Atle, Nederveen, Aart, Hendrikse, Jeroen, Asllani, Iris, and Barkhof, Frederik

Published
2020

46. ExploreASL: an image processing pipeline for multi-center ASL perfusion MRI studies

Author

Mutsaerts, Henri, primary, Petr, Jan, additional, Groot, Paul, additional, Vandemaele, Pieter, additional, Ingala, Silvia, additional, Robertson, Andrew D, additional, Václavů, Lena, additional, Groote, Inge, additional, Kuijf, Hugo, additional, Zelaya, Fernando, additional, O’Daly, Owen, additional, Hilal, Saima, additional, Wink, Alle Meije, additional, Kant, Ilse, additional, Caan, Matthan W.A., additional, Morgan, Catherine, additional, de Bresser, Jeroen, additional, Lysvik, Elisabeth, additional, Schrantee, Anouk, additional, Bjørnebekk, Astrid, additional, Clement, Patricia, additional, Shirzadi, Zahra, additional, Kuijer, Joost P.A., additional, Anazodo, Udunna C., additional, Pajkrt, Dasja, additional, Richard, Edo, additional, Bokkers, Reinoud P.H., additional, Reneman, Liesbeth, additional, Masellis, Mario, additional, Günther, Matthias, additional, MacIntosh, Bradley J., additional, Achten, Eric, additional, Chappell, Michael A., additional, van Osch, Matthias J.P., additional, Golay, Xavier, additional, Thomas, David L., additional, de Vita, Enrico, additional, Bjørnerud, Atle, additional, Nederveen, Aart, additional, Hendrikse, Jeroen, additional, Asllani, Iris, additional, and Barkhof, Frederik, additional

Published
2019
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47. Cognitive and socioemotional functioning at 4½ years in children born to mothers who have received treatment for substance-abuse problems while pregnant

Author

Haabrekke, Kristin Johanne Økern, Siqveland, Torill Sundet, Nygaard, Egil, Bjørnebekk, Astrid, Slinning, Kari, Wentzel-Larsen, Tore, Walhovd, Kristine B, Smith, Lars, and Moe, Vibeke

Abstract

Cognitive and socioemotional functioning at 4½ years of age were examined in children born to mothers with substance‐abuse problems (n = 22) recruited from residential treatment institutions while pregnant, and then compared to children born to mothers with mental health problems (n = 18) and children from a low‐risk group (n = 26). No significant group differences in cognitive functioning were found, but the children born to mothers with substance‐abuse problems showed more caregiver‐reported socioemotional problems than did the low‐risk children, like the children born to mothers with mental health problems. Birth weight had an effect on internalizing problems at 4½ years and mediated the relation between group and socioemotional problems, although not when controlling for caregiver education, single parenthood, and anxiety and depression. At 4½ years, 7 children born to mothers with substance‐abuse problems were placed in foster care. These children had lower birth weight and higher caregiver‐rated internalizing problems. In addition to emphasizing the importance of the quality of the prenatal environment, this study suggests that families with previous substance abuse are in need of long‐term follow‐up to address socioemotional problems and enhance further positive child cognitive development. The foster‐placed children may be in particular need of long‐term follow‐up.

Published
2018

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