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11. Detection of antipituitary and antihypothalamus antibodies to investigate the role of pituitary or hypothalamic autoimmunity in patients with selective idiopathic hypopituitarism

Author

De Bellis, Annamaria, Pane, Elena, Bellastella, Giuseppe, Sinisi, Antonio A., Colella, Caterina, Giordano, Roberta, Giavoli, Claudia, Lania, Andrea, Ambrosio, Maria R., Di Somma, Carolina, Zatelli, Maria C., Arvat, Emanuela, Colao, Annamaria, Bizzarro, Antonio, and Bellastella, Antonio

Published
2011
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12. Predictive Role of the Immunostaining Pattern of Immunofluorescence and the Titers of Antipituitary Antibodies at Presentation for the Occurrence of Autoimmune Hypopituitarism in Patients with Autoimmune Polyendocrine Syndromes over a Five-Year Follow-Up

Author

Bellastella, Giuseppe, Rotondi, Mario, Pane, Elena, Dello Iacovo, Assunta, Pirali, Barbara, Dalla Mora, Liliana, Falorni, Alberto, Sinisi, Antonio Agostino, Bizzarro, Antonio, Colao, Annamaria, Chiovato, Luca, and De Bellis, Annamaria

Published
2010

20. Central Diabetes Insipidus and Autoimmunity: Relationship between the Occurrence of Antibodies to Arginine Vasopressin-Secreting Cells and Clinical, Immunological, and Radiological Features in a Large Cohort of Patients with Central Diabetes Insipidus of Known and Unknown Etiology

Author

Pivonello, Rosario, De Bellis, Annamaria, Faggiano, Antongiulio, Di Salle, Francesco, Petretta, Mario, Di Somma, Carolina, Perrino, Silvia, Altucci, Paolo, Bizzarro, Antonio, Bellastella, Antonio, Lombardi, Gaetano, and Colao, Annamaria

Published
2003

26. Longitudinal behavior of autoimmune GH deficiency: from childhood to transition age

Author

De Bellis, Annamaria, Bellastella, Giuseppe, Maiorino, Maria Ida, Aitella, Ernesto, Lucci, Emma, Cozzolino, Domenico, Bellastella, Antonio, Bizzarro, Antonio, Giugliano, Dario, Esposito, Katherine, Arvat, E, Beck Peccoz, P, Betterle, C, Colao, A, Cannavo', Salvatore, Chiovato, L, Delvecchio, M, Giordano, R, Ghigo, E, Mantero, F, Persani, L, Rotondi, M, Salerno, M, Spada, A, Zatelli, Mc, De Bellis, A, Bellastella, G, Maiorino, Mi, Aitella, E, Lucci, E, Cozzolino, D, Bellastella, A, Bizzarro, A, Giugliano, D, Esposito, K, Italian Autoimmune Hypophysitis Network, Group., De Bellis, Annamaria, Bellastella, Giuseppe, Maiorino, Maria Ida, Aitella, Ernesto, Lucci, Emma, Cozzolino, Domenico, Bellastella, Antonio, Bizzarro, Antonio, Giugliano, Dario, Esposito, Katherine, and Salerno, Mariacarolina

Subjects
Male, Hydrocortisone, Endocrinology, Diabetes and Metabolism, Remission, Spontaneous, Thyrotropin, Spontaneous remission, 0302 clinical medicine, Endocrinology, Autoimmune Hypophysitis, Longitudinal Studies, Insulin-Like Growth Factor I, Child, Human Growth Hormone, Medicine (all), Remission Induction, General Medicine, Recombinant Proteins, Diabetes and Metabolism, Transgender hormone therapy, Autoimmune hypophysitis, Triiodothyronine, Female, medicine.symptom, Gonadal Hormones, psychological phenomena and processes, Adolescent, Adrenocorticotropic Hormone, Autoantibodies, Autoimmune Hypophysitis, Child, Dwarfism, Pituitary, Follicle Stimulating Hormone, Gonadal Hormones, Hormone Replacement Therapy, Human Growth Hormone, Humans, Hydrocortisone, Insulin-Like Growth Factor I, Longitudinal Studies, Luteinizing Hormone, Male, Prolactin, Recombinant Proteins, Remission Induction, Remission, Spontaneous, Somatotrophs, Thyrotropin, Thyroxine, Triiodothyronine, Young Adult, Endocrinology, Endocrinology, Diabetes and Metabolism, Medicine (all), medicine.drug, Delayed puberty, Isolated hypogonadotropic hypogonadism, medicine.medical_specialty, Adolescent, Somatotropic cell, Hormone Replacement Therapy, Remission, education, Dwarfism, 030209 endocrinology & metabolism, Adrenocorticotropic hormone, Young Adult, 03 medical and health sciences, Adrenocorticotropic Hormone, Internal medicine, mental disorders, medicine, Humans, Dwarfism, Pituitary, Autoantibodies, business.industry, Spontaneous, Luteinizing Hormone, medicine.disease, Somatotrophs, Prolactin, Thyroxine, Pituitary, Longitudinal behavior, autoimmune GH deficiency, growth hormone, childhood, transition age, Follicle Stimulating Hormone, business, 030217 neurology & neurosurgery
Abstract

BackgroundSome cases of apparently idiopathic GH deficiency (GHD) may be caused by pituitary autoimmunity.ObjectiveTo study the variations in pituitary function and antipituitary antibodies (APA) from childhood to transition age in patients with apparently idiopathic GHD.DesignWe conducted a longitudinal study.Patients and methodsPituitary function and APA detection by immunofluorescence were investigated in 24 childhood patients with isolated GHD before starting recombinant GH therapy and after the stopping of this therapy in transition age. Sera of patients positive for APA were processed by double immunofluorescence to identify their pituitary target.ResultsAt diagnosis, 16 out of 24 patients were APA positive targeting only somatotrophs (group 1), while the remaining eight were APA negative (group 2). When retested off therapy, 12 out of 16 patients in group 1 persisted being APA positive, while the remaining four became negative with recovery of pituitary function. All patients in group 2 persisted being APA negative but still showing GHD. Of the 12 patients persistently APA positive, eight with confirmed GHD showed APA still targeting somatotrophs, whereas four showed APA targeting only gonadotrophs associated with isolated hypogonadotropic hypogonadism (HH).ConclusionPatients with APA at middle but not at high titer in childhood may show a remission of autoimmune GHD in childhood after GH replacement therapy. As APA may shift their target in transition period, an early characterization of APA by double immunofluorescence is advisable in APA positive GHD patients showing delayed puberty, to allow an early diagnosis and an appropriate therapy, thus preventing the progression toward HH.

Published
2016

27. Levels of Adrenocortical Autoantibodies Correlate with the Degree of Adrenal Dysfunction in Subjects with Preclinical Addison's Disease

Author

LURETI S, DE BELLIS, Annamaria, MUCCITELLI IV, CALCINARO F, BIZZARRO, Antonio, ROSSI R, BELLASTELLA A, SANTEUSANIO F, FALORNI S., Lureti, S, DE BELLIS, Annamaria, Muccitelli, Iv, Calcinaro, F, Bizzarro, Antonio, Rossi, R, Bellastella, A, Santeusanio, F, and Falorni, S.

Subjects
anticorpi anti-21-idrossilasi, Endocrinology, Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Clinical Biochemistry, Morbo di Addison, predizione, fattori di rischio, Biochemistry
Published
1998

28. Autoimmune thyroid disease and neuroendocrine gastric tumors: early detection and efficacy of somatostatin analogue treatment

Author

Accardo G., Renzullo A., DE BELLIS, Annamaria, BIZZARRO, Antonio, ROMANO, Marco, FEDERICO, Alessandro, Gravina A. G., Faggiano A., Marotta V., Esposito D., Bellastella A., PASQUALI, Daniela, Accardo, G., Renzullo, A., DE BELLIS, Annamaria, Bizzarro, Antonio, Romano, Marco, Federico, Alessandro, Gravina, A. G., Faggiano, A., Marotta, V., Esposito, D., Bellastella, A., and Pasquali, Daniela

Published
2012

29. Prospective investigation of pituitary functions in patients with acute infectious meningitis: is acute meningitis induced pituitary dysfunction associated with autoimmunity?

Author

Tanriverdi F, De Bellis A, Teksahin H, Alp E, BIZZARRO, Antonio, SINISI, Antonio Agostino, BELLASTELLA, Giuseppe, AMORESANO PAGLIONICO, Vanda, Bellastella A, Unluhizarci K, Doganay M, Kelestimur F., DE BELLIS, Annamaria, Tanriverdi, F, De Bellis, A, Teksahin, H, Alp, E, Bizzarro, Antonio, Sinisi, Antonio Agostino, Bellastella, Giuseppe, AMORESANO PAGLIONICO, Vanda, Bellastella, A, Unluhizarci, K, Doganay, M, Kelestimur, F., and DE BELLIS, Annamaria

Published
2012

30. Simultaneous evaluation of the circulating levels of both Th1 and Th2 chemokines in patients with autoimmune Addison's disease

Author

BELLASTELLA, Giuseppe, ROTONDI M, PANE E, COSTANTINI S, COLELLA C, CALEMMA R, CAPONE F, FALORNI A, CASTELLO G, SINISI, Antonio Agostino, BIZZARRO, Antonio, CHIOVATO L, BELLASTELLA A, DE BELLIS, Annamaria, Bellastella, Giuseppe, Rotondi, M, Pane, E, Costantini, S, Colella, C, Calemma, R, Capone, F, Falorni, A, Castello, G, Sinisi, Antonio Agostino, Bizzarro, Antonio, Chiovato, L, Bellastella, A, and DE BELLIS, Annamaria

Subjects
Adult, Male, Morbo di Addison, autoimmunità surrenalica, chemochine, Middle Aged, Th1 Cells, Young Adult, Th2 Cells, Addison Disease, Humans, Female, Chemokines, Aged, Autoantibodies
Abstract

BACKGROUND: Chemokines play a key role in the recruitment of the immune cells into the autoimmune process. Thus, the simultaneous evaluation of circulating levels of Th1-related chemokines, such as CX chemokine ligand 10 (CXCL10) and macrophage inflammatory proteins 1α (CCL3/MIP-1α), and Th2-related chemokines, such as macrophage inflammatory proteins 1 β (CCL4/MIP-1β) could be useful in the approach to some autoimmune diseases, including autoimmune Addison's disease (AAD). AIM: To evaluate plasmatic levels of MIP-1α, MIP-1β, CXCL10 and adrenocortical antibodies in patients with AAD under treatment with corticosteroids. PATIENTS AND METHODS: Twelve women and 5 men (group 1) were divided in 2 subgroups: 9 subsjects with isolated AAD (group 1a) and 8 with AAD associated with chronic autoimmune thyroiditis (group 1b). MIP-1α, MIP- 1β and CXCL10 were evaluated in the serum of all patients and in 20 healthy controls, using a system for microarray suspension. RESULTS: The levels of MIP-1α, MIP-1β and CXCL10 resulted significantly increased vs controls (p

Published
2010

31. Pituitary Autoimmunity

Author

DE BELLIS, Annamaria, BIZZARRO, Antonio, BELLASTELLA A., GEORGE S. EISENBARTH, DE BELLIS, Annamaria, Bizzarro, Antonio, and Bellastella, A.

Published
2010

32. Anti-Pituitary Antibodies in Children With Newly Diagnosed Celiac Disease: A Novel Finding Contributing to Linear-Growth Impairment

Author

DELVECCHIO M, DE BELLIS, Annamaria, FRANCAVILLA R, RUTIGLIANO V, PREDIERI B, INDRIO F, DE VENUTO D, SINISI AA, BIZZARRO, Antonio, BELLASTELLA A, IUGHETTI L, CAVALLO L, ITALIAN AUTOIMMUNE HYPOPHYSITIS NETWORK STUDY, Delvecchio, M, DE BELLIS, Annamaria, Francavilla, R, Rutigliano, V, Predieri, B, Indrio, F, DE VENUTO, D, Sinisi, Aa, Bizzarro, Antonio, Bellastella, A, Iughetti, L, Cavallo, L, and ITALIAN AUTOIMMUNE HYPOPHYSITIS NETWORK, Study

Published
2010

33. Role of prolactin in autoimmune diseases

Author

DE BELLIS, Annamaria, BIZZARRO, Antonio, ANTONIO BELLASTELLA, SARA E. WALKER LUIS J.JARA, DE BELLIS, Annamaria, Bizzarro, Antonio, and Antonio, Bellastella

Published
2008

34. (2008). Effect of long-term cabergoline therapy on the immunological pattern and pituitary function of patients with idiopathic hyperprolactinaemia positive for antipituitary antibodies. 2008

Author

DE BELLIS, Annamaria, COLAO A, SAVOIA A, CORONELLA C, TIRELLI G, CONTE M, PIVONELLO R, BELLASTELLA A, SINISI AA, BIZZARRO, Antonio, LOMBARDI G, BELLASTELLA, Giuseppe, DE BELLIS, Annamaria, Colao, A, Savoia, A, Coronella, C, Tirelli, G, Conte, M, Pivonello, R, Bellastella, A, Sinisi, Aa, Bizzarro, Antonio, Lombardi, G, and Bellastella, Giuseppe

Published
2008

36. ANTIBODIES AGAINST GONADOTROPIN-SECRETING CELLS IN PATIENTS WITH APPARENTLY IDIOPATHIC HYPOGONADOTROPIC HYPOGONADISM

Author

DE BELLIS, Annamaria, BIZZARRO, Antonio, BELLASTELLA, Giuseppe, PASQUALI, Daniela, Esposito D, Coronella C, Conte M, Ruocco G, Battaglia m, Tirelli G, Sinisi AA, Bellastella A., DE BELLIS, Annamaria, Esposito, D, Bizzarro, Antonio, Coronella, C, Conte, M, Bellastella, Giuseppe, Ruocco, G, Battaglia, M, Tirelli, G, Pasquali, Daniela, Sinisi, Aa, and Bellastella, A.

Published
2006

38. Autoimmunità e ipofisi anteriore

Author

BIZZARRO, Antonio, FEOLA G, CORONELLA C, SANSONE D, GUAGLIONE M, BELLASTELLA, Giuseppe, PERRINO S, DE BELLIS, Annamaria, Bizzarro, Antonio, Feola, G, Coronella, C, Sansone, D, Guaglione, M, Bellastella, Giuseppe, Perrino, S, and DE BELLIS, Annamaria

Published
2002

39. Sindromi poliendocrine autoimmuni

Author

Bellastella A, De Bellis A, BIZZARRO, Antonio, Sinisi AA, PASQUALI, Daniela, BELLASTELLA A, FENZI G, GIUGLIANO D, LOMBARDI G, RICCARDI G, Bellastella, A, DE BELLIS, Annamaria, Pasquali, Daniela, Bizzarro, Antonio, Sinisi, Aa, Bartoli - Gensini - Laffi - Lucivero - Trimarco, and De Bellis, A

Published
2002

40. neoplasie endocrine multiple

Author

BELLASTELLA A, PASQUALI, Daniela, DE BELLIS, Annamaria, BIZZARRO, Antonio, SINISI AA, BELLASTELLA A, FENZI G, GIUGLIANO D, LOMBARDI G, RICCIARDI C, Bellastella, A, Pasquali, Daniela, DE BELLIS, Annamaria, Bizzarro, Antonio, and Sinisi, Aa

Published
2002

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